Explicit definitions of potentially inappropriate prescriptions of antibiotics in older patients: a compilation derived from a systematic review. Baclet, N., Ficheur, G., Alfandari, S., Ferret, L., Senneville, E., Chazard, E., & Beuscart, J. International Journal of Antimicrobial Agents, August, 2017.
Explicit definitions of potentially inappropriate prescriptions of antibiotics in older patients: a compilation derived from a systematic review [link]Paper  doi  abstract   bibtex   
CONTEXT: Potentially inappropriate prescriptions (PIPs) of antibiotics (antibiotic-PIPs) are generally detected by applying implicit definitions based on expert opinion. Explicit definitions are less frequently used, even though this approach would enable the automated detection of antibiotic-PIPs in electronic health records. Here, we systematically reviewed explicit definitions of antibiotic-PIPs used in studies of older adults. METHOD: We searched the MEDLINE(®), Scopus(®) and Web of Science(TM) core collection databases with a combination of three terms and their synonyms: "potentially inappropriate prescription" AND "antibiotic treatment" AND "older patients". After the standardized selection of publications, explicit definitions of antibiotic-PIPs were extracted and classified into infectious disease domains and sub-domains. RESULTS: A total of 600 search queries identified 4,270 records, 93 of which were selected for review. We found 160 mentions of antibiotic-PIPs, corresponding to 62 distinct definitions in 19 infectious disease domains. Nearly half of the definitions were related to upper respiratory tract infections (n=11 definitions; 17.7%), lower respiratory tract infections (n=8; 12.9%) and drug-drug interactions (n=11; 17.7%). Almost 75% of the definitions (n=46) were mentioned in a single study only. Only three definitions concerned critically important antibiotics, such as third-generation cephalosporins and fluoroquinolones. CONCLUSION: Our systematic review identified 62 explicit definitions of antibiotic-PIPs. Most of the definitions were not found in more than one study, and they varied in the degree of precision. We advocate the implementation of an expert consensus on explicit definitions of antibiotic-PIPs that correspond to today's challenges in public health.
@article{baclet_explicit_2017,
	title = {Explicit definitions of potentially inappropriate prescriptions of antibiotics in older patients: a compilation derived from a systematic review},
	issn = {1872-7913},
	shorttitle = {Explicit definitions of potentially inappropriate prescriptions of antibiotics in older patients},
	url = {https://nextcloud.univ-lille.fr/index.php/s/qr4PSf9eqC9DGKM},
	doi = {10.1016/j.ijantimicag.2017.08.011},
	abstract = {CONTEXT: Potentially inappropriate prescriptions (PIPs) of antibiotics (antibiotic-PIPs) are generally detected by applying implicit definitions based on expert opinion. Explicit definitions are less frequently used, even though this approach would enable the automated detection of antibiotic-PIPs in electronic health records. Here, we systematically reviewed explicit definitions of antibiotic-PIPs used in studies of older adults.
METHOD: We searched the MEDLINE(®), Scopus(®) and Web of Science(TM) core collection databases with a combination of three terms and their synonyms: "potentially inappropriate prescription" AND "antibiotic treatment" AND "older patients". After the standardized selection of publications, explicit definitions of antibiotic-PIPs were extracted and classified into infectious disease domains and sub-domains.
RESULTS: A total of 600 search queries identified 4,270 records, 93 of which were selected for review. We found 160 mentions of antibiotic-PIPs, corresponding to 62 distinct definitions in 19 infectious disease domains. Nearly half of the definitions were related to upper respiratory tract infections (n=11 definitions; 17.7\%), lower respiratory tract infections (n=8; 12.9\%) and drug-drug interactions (n=11; 17.7\%). Almost 75\% of the definitions (n=46) were mentioned in a single study only. Only three definitions concerned critically important antibiotics, such as third-generation cephalosporins and fluoroquinolones.
CONCLUSION: Our systematic review identified 62 explicit definitions of antibiotic-PIPs. Most of the definitions were not found in more than one study, and they varied in the degree of precision. We advocate the implementation of an expert consensus on explicit definitions of antibiotic-PIPs that correspond to today's challenges in public health.},
	language = {eng},
	journal = {International Journal of Antimicrobial Agents},
	author = {Baclet, Nicolas and Ficheur, Grégoire and Alfandari, Serge and Ferret, Laurie and Senneville, Eric and Chazard, Emmanuel and Beuscart, Jean-Baptiste},
	month = aug,
	year = {2017},
	pmid = {28803931},
	keywords = {Antibiotics, Elderly, Potentially Inappropriate Prescription},
}

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