BAPS 2: enhanced possibilities for the analysis of genetic population structure. Corander, J., Waldmann, P., Marttinen, P., & Sillanpää, M. J. Bioinformatics, 20(15):2363–2369, October, 2004.
BAPS 2: enhanced possibilities for the analysis of genetic population structure [link]Paper  doi  abstract   bibtex   
Summary: Bayesian statistical methods based on simulation techniques have recently been shown to provide powerful tools for the analysis of genetic population structure. We have previously developed a Markov chain Monte Carlo (MCMC) algorithm for characterizing genetically divergent groups based on molecular markers and geographical sampling design of the dataset. However, for large-scale datasets such algorithms may get stuck to local maxima in the parameter space. Therefore, we have modified our earlier algorithm to support multiple parallel MCMC chains, with enhanced features that enable considerably faster and more reliable estimation compared to the earlier version of the algorithm. We consider also a hierarchical tree representation, from which a Bayesian model-averaged structure estimate can be extracted. The algorithm is implemented in a computer program that features a user-friendly interface and built-in graphics. The enhanced features are illustrated by analyses of simulated data and an extensive human molecular dataset.Availability: Freely available at http://www.rni.helsinki.fi/~jic/bapspage.html
@article{corander_baps_2004,
	title = {{BAPS} 2: enhanced possibilities for the analysis of genetic population structure},
	volume = {20},
	issn = {1367-4803},
	shorttitle = {{BAPS} 2},
	url = {https://doi.org/10.1093/bioinformatics/bth250},
	doi = {10.1093/bioinformatics/bth250},
	abstract = {Summary: Bayesian statistical methods based on simulation techniques have recently been shown to provide powerful tools for the analysis of genetic population structure. We have previously developed a Markov chain Monte Carlo (MCMC) algorithm for characterizing genetically divergent groups based on molecular markers and geographical sampling design of the dataset. However, for large-scale datasets such algorithms may get stuck to local maxima in the parameter space. Therefore, we have modified our earlier algorithm to support multiple parallel MCMC chains, with enhanced features that enable considerably faster and more reliable estimation compared to the earlier version of the algorithm. We consider also a hierarchical tree representation, from which a Bayesian model-averaged structure estimate can be extracted. The algorithm is implemented in a computer program that features a user-friendly interface and built-in graphics. The enhanced features are illustrated by analyses of simulated data and an extensive human molecular dataset.Availability: Freely available at http://www.rni.helsinki.fi/{\textasciitilde}jic/bapspage.html},
	number = {15},
	urldate = {2021-06-30},
	journal = {Bioinformatics},
	author = {Corander, Jukka and Waldmann, Patrik and Marttinen, Pekka and Sillanpää, Mikko J.},
	month = oct,
	year = {2004},
	pages = {2363--2369},
}

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