Contrasting effects of coplanar versus non-coplanar PCB congeners on immunomodulation and CYP1A levels (determined using an adapted ELISA method) in the common sea star Asterias rubens L. Danis, B., Goriely, S., Dubois, P., Fowler, S., W., Flamand, V., & Warnau, M. Aquatic toxicology (Amsterdam, Netherlands), 69(4):371-83, 9, 2004. Paper Website abstract bibtex Biological effects of two structurally contrasting PCB congeners (coplanar 77 and non coplanar 153) were investigated by measuring the induction of CYP1A immunopositive protein (CYP1A IPP) in the pyloric caeca and the production of reactive oxygen species (ROS) by amoebocytes in the common sea star Asterias rubens. CYP1A IPP was quantified using a specially designed ELISA which uses competitive binding between sea stars and trout CYP1A IPPs. Only the coplanar congener had a significant effect on the two considered biological responses. Intensity of the effects was dose-dependent. However, the highest dose of PCB 77 induced a dramatic decrease of ROS production. It is concluded that coplanar PCBs straightforwardly affect key biological processes such as the immune system and mixed-function oxidase (MFO) system.
@article{
title = {Contrasting effects of coplanar versus non-coplanar PCB congeners on immunomodulation and CYP1A levels (determined using an adapted ELISA method) in the common sea star Asterias rubens L.},
type = {article},
year = {2004},
identifiers = {[object Object]},
keywords = {Acute Toxicity Tests,Animals,Blotting, Western,Cytochrome P-450 CYP1A1,Cytochrome P-450 CYP1A1: metabolism,Dose-Response Relationship, Drug,Enzyme Activation,Enzyme Activation: drug effects,Enzyme-Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assay: methods,Polychlorinated Biphenyls,Polychlorinated Biphenyls: toxicity,Pylorus,Pylorus: metabolism,Reactive Oxygen Species,Reactive Oxygen Species: metabolism,Starfish,Starfish: immunology,Starfish: metabolism},
pages = {371-83},
volume = {69},
websites = {http://dx.doi.org/10.1016/j.aquatox.2004.06.008},
month = {9},
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abstract = {Biological effects of two structurally contrasting PCB congeners (coplanar 77 and non coplanar 153) were investigated by measuring the induction of CYP1A immunopositive protein (CYP1A IPP) in the pyloric caeca and the production of reactive oxygen species (ROS) by amoebocytes in the common sea star Asterias rubens. CYP1A IPP was quantified using a specially designed ELISA which uses competitive binding between sea stars and trout CYP1A IPPs. Only the coplanar congener had a significant effect on the two considered biological responses. Intensity of the effects was dose-dependent. However, the highest dose of PCB 77 induced a dramatic decrease of ROS production. It is concluded that coplanar PCBs straightforwardly affect key biological processes such as the immune system and mixed-function oxidase (MFO) system.},
bibtype = {article},
author = {Danis, Bruno and Goriely, Stanislas and Dubois, Philippe and Fowler, Scott W and Flamand, Véronique and Warnau, Michel},
journal = {Aquatic toxicology (Amsterdam, Netherlands)},
number = {4}
}
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