Retrograde Extraperitoneal Laparoscopic Prostatectomy (RELP). A Prospective Study about 1,000 Consecutive Patients, with Oncological and Functional Results. Dubernard, P., Chaffange, P., Pacheco, P., Pricaz, E., Vaziri, N., Vinet, M., Chalabreysse, P., Rochat, C., Ficheur, G., & Chazard, E. Urology Journal, July, 2021. doi abstract bibtex PURPOSE: Usual laparoscopic surgery of localized prostate cancer uses antegrade dissection. We describe and evaluate the original RELP (Retrograde Extraperitoneal Laparoscopic Prostatectomy). MATERIALS AND METHODS: A prospective cohort of 1005 patients with clinical localized cancer prostate were operated from December 1999 to September 2013, in Lyon (France), and followed up to 172 months (median: 60 months). Patients encountered a RELP procedure, a totally extra-peritoneal approach with a retrograde dissection from the apex to the bladder neck, and ascending dissection of the erectile neurovascular bundles, facilitated by the 30° optic telescope. Adjunctive treatments were: immediate radiotherapy (9.2%), salvage radiotherapy (13.4%), androgen deprivation therapy (10.8%), chemotherapy (1.4%), no treatment (75.8%). Results The mean age was 63.4, the Gleason score was 4+3 or worse in 24.9%, there were 2.3% unifocal tumors. The pathology stages were pT2A (8.71%), pT2B (2.80%), pT2C (69.0%), pT3A (13.1%), and pT3B (6.41%). There were 60.8% negative margins (R0) in total (90.1% for basal locations, and 75.8% for apical locations). The mean operating time was 115 minutes for the last 100 patients. The BPFSR (biological progression free survival rate, PSA≤0.10 ng/ml) was 71.9% at 5 years, and 61.4% at 10 years. The cancer specific survival rate was 99.4% at 5 years, and 98.3% at 10 years. After 12 months, 88.6% of patients did not require an incontinence pad, and 67.0% retained the pre-operative quality of their erection. CONCLUSION: RELP yields good oncologic results and quality of life, as good as robot-assisted surgery.
@article{dubernard_retrograde_2021,
title = {Retrograde {Extraperitoneal} {Laparoscopic} {Prostatectomy} ({RELP}). {A} {Prospective} {Study} about 1,000 {Consecutive} {Patients}, with {Oncological} and {Functional} {Results}},
issn = {1735-546X},
doi = {10.22037/uj.v18i.6233},
abstract = {PURPOSE: Usual laparoscopic surgery of localized prostate cancer uses antegrade dissection. We describe and evaluate the original RELP (Retrograde Extraperitoneal Laparoscopic Prostatectomy).
MATERIALS AND METHODS: A prospective cohort of 1005 patients with clinical localized cancer prostate were operated from December 1999 to September 2013, in Lyon (France), and followed up to 172 months (median: 60 months). Patients encountered a RELP procedure, a totally extra-peritoneal approach with a retrograde dissection from the apex to the bladder neck, and ascending dissection of the erectile neurovascular bundles, facilitated by the 30° optic telescope. Adjunctive treatments were: immediate radiotherapy (9.2\%), salvage radiotherapy (13.4\%), androgen deprivation therapy (10.8\%), chemotherapy (1.4\%), no treatment (75.8\%). Results The mean age was 63.4, the Gleason score was 4+3 or worse in 24.9\%, there were 2.3\% unifocal tumors. The pathology stages were pT2A (8.71\%), pT2B (2.80\%), pT2C (69.0\%), pT3A (13.1\%), and pT3B (6.41\%). There were 60.8\% negative margins (R0) in total (90.1\% for basal locations, and 75.8\% for apical locations). The mean operating time was 115 minutes for the last 100 patients. The BPFSR (biological progression free survival rate, PSA≤0.10 ng/ml) was 71.9\% at 5 years, and 61.4\% at 10 years. The cancer specific survival rate was 99.4\% at 5 years, and 98.3\% at 10 years. After 12 months, 88.6\% of patients did not require an incontinence pad, and 67.0\% retained the pre-operative quality of their erection.
CONCLUSION: RELP yields good oncologic results and quality of life, as good as robot-assisted surgery.},
language = {eng},
journal = {Urology Journal},
author = {Dubernard, Pierre and Chaffange, Pierre and Pacheco, Philippe and Pricaz, Elie and Vaziri, Nader and Vinet, Maxime and Chalabreysse, Philippe and Rochat, Charles-Henry and Ficheur, Grégoire and Chazard, Emmanuel},
month = jul,
year = {2021},
pmid = {34308534},
keywords = {Functional Results, Laparoscopy, Oncological Results, Prostatectomy, Prostatic Neoplasms, Retrograde Extraperitoneal Laparoscopic Prostatectomy},
}
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MATERIALS AND METHODS: A prospective cohort of 1005 patients with clinical localized cancer prostate were operated from December 1999 to September 2013, in Lyon (France), and followed up to 172 months (median: 60 months). Patients encountered a RELP procedure, a totally extra-peritoneal approach with a retrograde dissection from the apex to the bladder neck, and ascending dissection of the erectile neurovascular bundles, facilitated by the 30° optic telescope. Adjunctive treatments were: immediate radiotherapy (9.2%), salvage radiotherapy (13.4%), androgen deprivation therapy (10.8%), chemotherapy (1.4%), no treatment (75.8%). Results The mean age was 63.4, the Gleason score was 4+3 or worse in 24.9%, there were 2.3% unifocal tumors. The pathology stages were pT2A (8.71%), pT2B (2.80%), pT2C (69.0%), pT3A (13.1%), and pT3B (6.41%). There were 60.8% negative margins (R0) in total (90.1% for basal locations, and 75.8% for apical locations). The mean operating time was 115 minutes for the last 100 patients. The BPFSR (biological progression free survival rate, PSA≤0.10 ng/ml) was 71.9% at 5 years, and 61.4% at 10 years. The cancer specific survival rate was 99.4% at 5 years, and 98.3% at 10 years. After 12 months, 88.6% of patients did not require an incontinence pad, and 67.0% retained the pre-operative quality of their erection. CONCLUSION: RELP yields good oncologic results and quality of life, as good as robot-assisted surgery.","language":"eng","journal":"Urology Journal","author":[{"propositions":[],"lastnames":["Dubernard"],"firstnames":["Pierre"],"suffixes":[]},{"propositions":[],"lastnames":["Chaffange"],"firstnames":["Pierre"],"suffixes":[]},{"propositions":[],"lastnames":["Pacheco"],"firstnames":["Philippe"],"suffixes":[]},{"propositions":[],"lastnames":["Pricaz"],"firstnames":["Elie"],"suffixes":[]},{"propositions":[],"lastnames":["Vaziri"],"firstnames":["Nader"],"suffixes":[]},{"propositions":[],"lastnames":["Vinet"],"firstnames":["Maxime"],"suffixes":[]},{"propositions":[],"lastnames":["Chalabreysse"],"firstnames":["Philippe"],"suffixes":[]},{"propositions":[],"lastnames":["Rochat"],"firstnames":["Charles-Henry"],"suffixes":[]},{"propositions":[],"lastnames":["Ficheur"],"firstnames":["Grégoire"],"suffixes":[]},{"propositions":[],"lastnames":["Chazard"],"firstnames":["Emmanuel"],"suffixes":[]}],"month":"July","year":"2021","pmid":"34308534","keywords":"Functional Results, Laparoscopy, Oncological Results, Prostatectomy, Prostatic Neoplasms, Retrograde Extraperitoneal Laparoscopic Prostatectomy","bibtex":"@article{dubernard_retrograde_2021,\n\ttitle = {Retrograde {Extraperitoneal} {Laparoscopic} {Prostatectomy} ({RELP}). {A} {Prospective} {Study} about 1,000 {Consecutive} {Patients}, with {Oncological} and {Functional} {Results}},\n\tissn = {1735-546X},\n\tdoi = {10.22037/uj.v18i.6233},\n\tabstract = {PURPOSE: Usual laparoscopic surgery of localized prostate cancer uses antegrade dissection. We describe and evaluate the original RELP (Retrograde Extraperitoneal Laparoscopic Prostatectomy).\nMATERIALS AND METHODS: A prospective cohort of 1005 patients with clinical localized cancer prostate were operated from December 1999 to September 2013, in Lyon (France), and followed up to 172 months (median: 60 months). Patients encountered a RELP procedure, a totally extra-peritoneal approach with a retrograde dissection from the apex to the bladder neck, and ascending dissection of the erectile neurovascular bundles, facilitated by the 30° optic telescope. Adjunctive treatments were: immediate radiotherapy (9.2\\%), salvage radiotherapy (13.4\\%), androgen deprivation therapy (10.8\\%), chemotherapy (1.4\\%), no treatment (75.8\\%). Results The mean age was 63.4, the Gleason score was 4+3 or worse in 24.9\\%, there were 2.3\\% unifocal tumors. The pathology stages were pT2A (8.71\\%), pT2B (2.80\\%), pT2C (69.0\\%), pT3A (13.1\\%), and pT3B (6.41\\%). There were 60.8\\% negative margins (R0) in total (90.1\\% for basal locations, and 75.8\\% for apical locations). The mean operating time was 115 minutes for the last 100 patients. The BPFSR (biological progression free survival rate, PSA≤0.10 ng/ml) was 71.9\\% at 5 years, and 61.4\\% at 10 years. The cancer specific survival rate was 99.4\\% at 5 years, and 98.3\\% at 10 years. After 12 months, 88.6\\% of patients did not require an incontinence pad, and 67.0\\% retained the pre-operative quality of their erection.\nCONCLUSION: RELP yields good oncologic results and quality of life, as good as robot-assisted surgery.},\n\tlanguage = {eng},\n\tjournal = {Urology Journal},\n\tauthor = {Dubernard, Pierre and Chaffange, Pierre and Pacheco, Philippe and Pricaz, Elie and Vaziri, Nader and Vinet, Maxime and Chalabreysse, Philippe and Rochat, Charles-Henry and Ficheur, Grégoire and Chazard, Emmanuel},\n\tmonth = jul,\n\tyear = {2021},\n\tpmid = {34308534},\n\tkeywords = {Functional Results, Laparoscopy, Oncological Results, Prostatectomy, Prostatic Neoplasms, Retrograde Extraperitoneal Laparoscopic Prostatectomy},\n}\n\n","author_short":["Dubernard, P.","Chaffange, P.","Pacheco, P.","Pricaz, E.","Vaziri, N.","Vinet, M.","Chalabreysse, P.","Rochat, C.","Ficheur, G.","Chazard, E."],"key":"dubernard_retrograde_2021","id":"dubernard_retrograde_2021","bibbaseid":"dubernard-chaffange-pacheco-pricaz-vaziri-vinet-chalabreysse-rochat-etal-retrogradeextraperitoneallaparoscopicprostatectomyrelpaprospectivestudyabout1000consecutivepatientswithoncologicalandfunctionalresults-2021","role":"author","urls":{},"keyword":["Functional Results","Laparoscopy","Oncological Results","Prostatectomy","Prostatic Neoplasms","Retrograde Extraperitoneal Laparoscopic Prostatectomy"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/1597782/collections/MSB7W4UM/items?key=gxIPM4PJtMVcB8OpssCWodtP&format=bibtex&limit=100&start=0&sort=date","dataSources":["doevpoZ8x7wJceFTM"],"keywords":["functional results","laparoscopy","oncological results","prostatectomy","prostatic neoplasms","retrograde extraperitoneal laparoscopic prostatectomy"],"search_terms":["retrograde","extraperitoneal","laparoscopic","prostatectomy","relp","prospective","study","000","consecutive","patients","oncological","functional","results","dubernard","chaffange","pacheco","pricaz","vaziri","vinet","chalabreysse","rochat","ficheur","chazard"],"title":"Retrograde Extraperitoneal Laparoscopic Prostatectomy (RELP). A Prospective Study about 1,000 Consecutive Patients, with Oncological and Functional Results","year":2021}