Association between sarcopenia and risk of major adverse cardiac and cerebrovascular events-UK Biobank database. Jauffret, C., Périchon, R., Lamer, A., Cortet, B., Chazard, E., & Paccou, J. Journal of the American Geriatrics Society, 72(3):693–706, March, 2024. doi abstract bibtex BACKGROUND: Few studies on the risk of incident major adverse cardiac and cerebrovascular events (MACCEs) in sarcopenia have been reported. The objective was to assess the association between presarcopenia and sarcopenia and a higher risk of MACCEs. METHODS: This study on the UK Biobank prospective cohort, used data collected between 2006 and 2021. Community-dwelling Caucasian participants aged 37 to 73 years were included if values for Handgrip Strength (HGS) and Skeletal Muscle Index (SMI) were available and if no history of MACCEs was reported. Exposure was assessed using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. Muscle strength was measured using HGS, and muscle mass using the SMI. Presarcopenia was defined through the two definitions available in the literature, as low HGS with normal SMI and as normal HGS with low SMI, whereas sarcopenia was defined as low HGS with low SMI. The main outcome was to determine whether presarcopenia and/or sarcopenia were predictors of MACCEs (composite events). RESULTS: A total of 406,411 included participants (women: 55.7%) were included. At baseline, there were 18,257 (4.7%) presarcopenics-subgroup n°1 (low HGS only), 7940 (2.1%) presarcopenics-subgroup n°2 (low SMI only), and 1124 (0.3%) sarcopenics. Over a median follow-up of 12.1 years (IQR: [11.4; 12.8]), 28,300 participants (7.0%) were diagnosed with at least one event. Compared to NonSarc, presarcopenic (subgroups n°1 and n°2) and sarcopenic status were significantly associated with a higher risk of MACCEs (respectively fully adjusted HRs: HR = 1.25 [95% CI: 1.19; 1.31], HR = 1.33 [95% CI: 1.23; 1.45] and HR = 1.62 [95% CI: 1.34; 1.95]). CONCLUSIONS: In a community-dwelling population, the risk of MACCEs was higher in both presarcopenic and sarcopenic participants.
@article{jauffret_association_2024,
title = {Association between sarcopenia and risk of major adverse cardiac and cerebrovascular events-{UK} {Biobank} database},
volume = {72},
issn = {1532-5415},
doi = {10.1111/jgs.18664},
abstract = {BACKGROUND: Few studies on the risk of incident major adverse cardiac and cerebrovascular events (MACCEs) in sarcopenia have been reported. The objective was to assess the association between presarcopenia and sarcopenia and a higher risk of MACCEs.
METHODS: This study on the UK Biobank prospective cohort, used data collected between 2006 and 2021. Community-dwelling Caucasian participants aged 37 to 73 years were included if values for Handgrip Strength (HGS) and Skeletal Muscle Index (SMI) were available and if no history of MACCEs was reported. Exposure was assessed using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. Muscle strength was measured using HGS, and muscle mass using the SMI. Presarcopenia was defined through the two definitions available in the literature, as low HGS with normal SMI and as normal HGS with low SMI, whereas sarcopenia was defined as low HGS with low SMI. The main outcome was to determine whether presarcopenia and/or sarcopenia were predictors of MACCEs (composite events).
RESULTS: A total of 406,411 included participants (women: 55.7\%) were included. At baseline, there were 18,257 (4.7\%) presarcopenics-subgroup n°1 (low HGS only), 7940 (2.1\%) presarcopenics-subgroup n°2 (low SMI only), and 1124 (0.3\%) sarcopenics. Over a median follow-up of 12.1 years (IQR: [11.4; 12.8]), 28,300 participants (7.0\%) were diagnosed with at least one event. Compared to NonSarc, presarcopenic (subgroups n°1 and n°2) and sarcopenic status were significantly associated with a higher risk of MACCEs (respectively fully adjusted HRs: HR = 1.25 [95\% CI: 1.19; 1.31], HR = 1.33 [95\% CI: 1.23; 1.45] and HR = 1.62 [95\% CI: 1.34; 1.95]).
CONCLUSIONS: In a community-dwelling population, the risk of MACCEs was higher in both presarcopenic and sarcopenic participants.},
language = {eng},
number = {3},
journal = {Journal of the American Geriatrics Society},
author = {Jauffret, Charlotte and Périchon, Renaud and Lamer, Antoine and Cortet, Bernard and Chazard, Emmanuel and Paccou, Julien},
month = mar,
year = {2024},
pmid = {37945290},
keywords = {Aged, Biological Specimen Banks, Female, Hand Strength, Humans, Muscle, Skeletal, Prospective Studies, Sarcopenia, UK Biobank, major cardiac and cerebrovascular event, presarcopenia, sarcopenia},
pages = {693--706},
}
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{"_id":"rPgC92m8r3QwZYpNh","bibbaseid":"jauffret-prichon-lamer-cortet-chazard-paccou-associationbetweensarcopeniaandriskofmajoradversecardiacandcerebrovasculareventsukbiobankdatabase-2024","author_short":["Jauffret, C.","Périchon, R.","Lamer, A.","Cortet, B.","Chazard, E.","Paccou, J."],"bibdata":{"bibtype":"article","type":"article","title":"Association between sarcopenia and risk of major adverse cardiac and cerebrovascular events-UK Biobank database","volume":"72","issn":"1532-5415","doi":"10.1111/jgs.18664","abstract":"BACKGROUND: Few studies on the risk of incident major adverse cardiac and cerebrovascular events (MACCEs) in sarcopenia have been reported. The objective was to assess the association between presarcopenia and sarcopenia and a higher risk of MACCEs. METHODS: This study on the UK Biobank prospective cohort, used data collected between 2006 and 2021. Community-dwelling Caucasian participants aged 37 to 73 years were included if values for Handgrip Strength (HGS) and Skeletal Muscle Index (SMI) were available and if no history of MACCEs was reported. Exposure was assessed using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. Muscle strength was measured using HGS, and muscle mass using the SMI. Presarcopenia was defined through the two definitions available in the literature, as low HGS with normal SMI and as normal HGS with low SMI, whereas sarcopenia was defined as low HGS with low SMI. The main outcome was to determine whether presarcopenia and/or sarcopenia were predictors of MACCEs (composite events). RESULTS: A total of 406,411 included participants (women: 55.7%) were included. At baseline, there were 18,257 (4.7%) presarcopenics-subgroup n°1 (low HGS only), 7940 (2.1%) presarcopenics-subgroup n°2 (low SMI only), and 1124 (0.3%) sarcopenics. Over a median follow-up of 12.1 years (IQR: [11.4; 12.8]), 28,300 participants (7.0%) were diagnosed with at least one event. Compared to NonSarc, presarcopenic (subgroups n°1 and n°2) and sarcopenic status were significantly associated with a higher risk of MACCEs (respectively fully adjusted HRs: HR = 1.25 [95% CI: 1.19; 1.31], HR = 1.33 [95% CI: 1.23; 1.45] and HR = 1.62 [95% CI: 1.34; 1.95]). CONCLUSIONS: In a community-dwelling population, the risk of MACCEs was higher in both presarcopenic and sarcopenic participants.","language":"eng","number":"3","journal":"Journal of the American Geriatrics Society","author":[{"propositions":[],"lastnames":["Jauffret"],"firstnames":["Charlotte"],"suffixes":[]},{"propositions":[],"lastnames":["Périchon"],"firstnames":["Renaud"],"suffixes":[]},{"propositions":[],"lastnames":["Lamer"],"firstnames":["Antoine"],"suffixes":[]},{"propositions":[],"lastnames":["Cortet"],"firstnames":["Bernard"],"suffixes":[]},{"propositions":[],"lastnames":["Chazard"],"firstnames":["Emmanuel"],"suffixes":[]},{"propositions":[],"lastnames":["Paccou"],"firstnames":["Julien"],"suffixes":[]}],"month":"March","year":"2024","pmid":"37945290","keywords":"Aged, Biological Specimen Banks, Female, Hand Strength, Humans, Muscle, Skeletal, Prospective Studies, Sarcopenia, UK Biobank, major cardiac and cerebrovascular event, presarcopenia, sarcopenia","pages":"693–706","bibtex":"@article{jauffret_association_2024,\n\ttitle = {Association between sarcopenia and risk of major adverse cardiac and cerebrovascular events-{UK} {Biobank} database},\n\tvolume = {72},\n\tissn = {1532-5415},\n\tdoi = {10.1111/jgs.18664},\n\tabstract = {BACKGROUND: Few studies on the risk of incident major adverse cardiac and cerebrovascular events (MACCEs) in sarcopenia have been reported. The objective was to assess the association between presarcopenia and sarcopenia and a higher risk of MACCEs.\nMETHODS: This study on the UK Biobank prospective cohort, used data collected between 2006 and 2021. Community-dwelling Caucasian participants aged 37 to 73 years were included if values for Handgrip Strength (HGS) and Skeletal Muscle Index (SMI) were available and if no history of MACCEs was reported. Exposure was assessed using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. Muscle strength was measured using HGS, and muscle mass using the SMI. Presarcopenia was defined through the two definitions available in the literature, as low HGS with normal SMI and as normal HGS with low SMI, whereas sarcopenia was defined as low HGS with low SMI. The main outcome was to determine whether presarcopenia and/or sarcopenia were predictors of MACCEs (composite events).\nRESULTS: A total of 406,411 included participants (women: 55.7\\%) were included. At baseline, there were 18,257 (4.7\\%) presarcopenics-subgroup n°1 (low HGS only), 7940 (2.1\\%) presarcopenics-subgroup n°2 (low SMI only), and 1124 (0.3\\%) sarcopenics. Over a median follow-up of 12.1 years (IQR: [11.4; 12.8]), 28,300 participants (7.0\\%) were diagnosed with at least one event. Compared to NonSarc, presarcopenic (subgroups n°1 and n°2) and sarcopenic status were significantly associated with a higher risk of MACCEs (respectively fully adjusted HRs: HR = 1.25 [95\\% CI: 1.19; 1.31], HR = 1.33 [95\\% CI: 1.23; 1.45] and HR = 1.62 [95\\% CI: 1.34; 1.95]).\nCONCLUSIONS: In a community-dwelling population, the risk of MACCEs was higher in both presarcopenic and sarcopenic participants.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of the American Geriatrics Society},\n\tauthor = {Jauffret, Charlotte and Périchon, Renaud and Lamer, Antoine and Cortet, Bernard and Chazard, Emmanuel and Paccou, Julien},\n\tmonth = mar,\n\tyear = {2024},\n\tpmid = {37945290},\n\tkeywords = {Aged, Biological Specimen Banks, Female, Hand Strength, Humans, Muscle, Skeletal, Prospective Studies, Sarcopenia, UK Biobank, major cardiac and cerebrovascular event, presarcopenia, sarcopenia},\n\tpages = {693--706},\n}\n\n","author_short":["Jauffret, C.","Périchon, R.","Lamer, A.","Cortet, B.","Chazard, E.","Paccou, J."],"key":"jauffret_association_2024","id":"jauffret_association_2024","bibbaseid":"jauffret-prichon-lamer-cortet-chazard-paccou-associationbetweensarcopeniaandriskofmajoradversecardiacandcerebrovasculareventsukbiobankdatabase-2024","role":"author","urls":{},"keyword":["Aged","Biological Specimen Banks","Female","Hand Strength","Humans","Muscle","Skeletal","Prospective Studies","Sarcopenia","UK Biobank","major cardiac and cerebrovascular event","presarcopenia","sarcopenia"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/users/1597782/collections/MSB7W4UM/items?key=gxIPM4PJtMVcB8OpssCWodtP&format=bibtex&limit=100&start=0&sort=date","dataSources":["doevpoZ8x7wJceFTM"],"keywords":["aged","biological specimen banks","female","hand strength","humans","muscle","skeletal","prospective studies","sarcopenia","uk biobank","major cardiac and cerebrovascular event","presarcopenia","sarcopenia"],"search_terms":["association","between","sarcopenia","risk","major","adverse","cardiac","cerebrovascular","events","biobank","database","jauffret","périchon","lamer","cortet","chazard","paccou"],"title":"Association between sarcopenia and risk of major adverse cardiac and cerebrovascular events-UK Biobank database","year":2024}