No economic benefit of early knee reconstruction over optional delayed reconstruction for ACL tears: Registry enriched randomised controlled trial data. Kiadaliri, A. A., Englund, M., Lohmander, L. S., Carlsson, K. S., & Frobell, R. B. British journal of sports medicine, 50(9):558–563, May, 2016. Paper doi abstract bibtex BACKGROUND: To analyse 5-year cost-effectiveness of early versus optional delayed acute anterior cruciate ligament (ACL) reconstruction. METHODS: 121 young, active adults with acute ACL injury to a previously uninjured knee were randomised to early ACL reconstruction (n=62, within 10 weeks of injury) or optional delayed ACL reconstruction (n=59; 30 with ACL reconstruction within 6-55 months); all patients received similar structured rehabilitation. Real life data on health care utilisation and sick leave were obtained from regional and national registers. Costs and quality-adjusted life years (QALYs) were discounted at 3%. Full-analysis set (based on study randomisation) and as-treated analysis (according to actual treatment over 5 years) principles were applied. RESULTS: Mean cost of early ACL reconstruction was euro4695 higher than optional delayed ACL reconstruction (p=0.19) and provided an additional 0.13 QALYs (p=0.11). Full-analysis set showed incremental net benefit of early versus optional delayed ACL reconstruction was not statistically significantly different from zero at any level. As-treated analysis showed that costs for rehabilitation alone were euro13 650 less than early ACL reconstruction (p\textless0.001). Results were robust to sensitivity analyses. CONCLUSIONS: In young active adults with acute ACL injury, a strategy of early ACL reconstruction did not provide extra economic value over a strategy of optional delayed ACL reconstruction over a 5-year period. Results from this and previous reports of the KANON-trial imply that early identification of individuals who would benefit from either early ACL reconstruction or rehabilitation alone might reduce resource consumption and decrease risk of unnecessary overtreatment. TRIAL REGISTRATION: ISRCTN84752559.
@article{kiadaliri_no_2016,
title = {No economic benefit of early knee reconstruction over optional delayed reconstruction for {ACL} tears: {Registry} enriched randomised controlled trial data.},
volume = {50},
copyright = {Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/},
issn = {1473-0480 0306-3674},
url = {http://dx.doi.org/10.1136/bjsports-2015-095308},
doi = {10.1136/bjsports-2015-095308},
abstract = {BACKGROUND: To analyse 5-year cost-effectiveness of early versus optional delayed acute anterior cruciate ligament (ACL) reconstruction. METHODS: 121 young, active adults with acute ACL injury to a previously uninjured knee were randomised to early ACL reconstruction (n=62, within 10 weeks of injury) or optional delayed ACL reconstruction (n=59; 30 with ACL reconstruction within 6-55 months); all patients received similar structured rehabilitation. Real life data on health care utilisation and sick leave were obtained from regional and national registers. Costs and quality-adjusted life years (QALYs) were discounted at 3\%. Full-analysis set (based on study randomisation) and as-treated analysis (according to actual treatment over 5 years) principles were applied. RESULTS: Mean cost of early ACL reconstruction was euro4695 higher than optional delayed ACL reconstruction (p=0.19) and provided an additional 0.13 QALYs (p=0.11). Full-analysis set showed incremental net benefit of early versus optional delayed ACL reconstruction was not statistically significantly different from zero at any level. As-treated analysis showed that costs for rehabilitation alone were euro13 650 less than early ACL reconstruction (p{\textless}0.001). Results were robust to sensitivity analyses. CONCLUSIONS: In young active adults with acute ACL injury, a strategy of early ACL reconstruction did not provide extra economic value over a strategy of optional delayed ACL reconstruction over a 5-year period. Results from this and previous reports of the KANON-trial imply that early identification of individuals who would benefit from either early ACL reconstruction or rehabilitation alone might reduce resource consumption and decrease risk of unnecessary overtreatment. TRIAL REGISTRATION: ISRCTN84752559.},
language = {eng},
number = {9},
journal = {British journal of sports medicine},
author = {Kiadaliri, Aliasghar A. and Englund, Martin and Lohmander, L. Stefan and Carlsson, Katarina Steen and Frobell, Richard B.},
month = may,
year = {2016},
pmid = {26935859},
keywords = {Economics, Effectiveness, Knee ACL, Randomised controlled trial, Rehabilitation},
pages = {558--563},
}
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For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/","issn":"1473-0480 0306-3674","url":"http://dx.doi.org/10.1136/bjsports-2015-095308","doi":"10.1136/bjsports-2015-095308","abstract":"BACKGROUND: To analyse 5-year cost-effectiveness of early versus optional delayed acute anterior cruciate ligament (ACL) reconstruction. METHODS: 121 young, active adults with acute ACL injury to a previously uninjured knee were randomised to early ACL reconstruction (n=62, within 10 weeks of injury) or optional delayed ACL reconstruction (n=59; 30 with ACL reconstruction within 6-55 months); all patients received similar structured rehabilitation. Real life data on health care utilisation and sick leave were obtained from regional and national registers. Costs and quality-adjusted life years (QALYs) were discounted at 3%. Full-analysis set (based on study randomisation) and as-treated analysis (according to actual treatment over 5 years) principles were applied. RESULTS: Mean cost of early ACL reconstruction was euro4695 higher than optional delayed ACL reconstruction (p=0.19) and provided an additional 0.13 QALYs (p=0.11). Full-analysis set showed incremental net benefit of early versus optional delayed ACL reconstruction was not statistically significantly different from zero at any level. As-treated analysis showed that costs for rehabilitation alone were euro13 650 less than early ACL reconstruction (p\\textless0.001). Results were robust to sensitivity analyses. CONCLUSIONS: In young active adults with acute ACL injury, a strategy of early ACL reconstruction did not provide extra economic value over a strategy of optional delayed ACL reconstruction over a 5-year period. Results from this and previous reports of the KANON-trial imply that early identification of individuals who would benefit from either early ACL reconstruction or rehabilitation alone might reduce resource consumption and decrease risk of unnecessary overtreatment. TRIAL REGISTRATION: ISRCTN84752559.","language":"eng","number":"9","journal":"British journal of sports medicine","author":[{"propositions":[],"lastnames":["Kiadaliri"],"firstnames":["Aliasghar","A."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]},{"propositions":[],"lastnames":["Lohmander"],"firstnames":["L.","Stefan"],"suffixes":[]},{"propositions":[],"lastnames":["Carlsson"],"firstnames":["Katarina","Steen"],"suffixes":[]},{"propositions":[],"lastnames":["Frobell"],"firstnames":["Richard","B."],"suffixes":[]}],"month":"May","year":"2016","pmid":"26935859","keywords":"Economics, Effectiveness, Knee ACL, Randomised controlled trial, Rehabilitation","pages":"558–563","bibtex":"@article{kiadaliri_no_2016,\n\ttitle = {No economic benefit of early knee reconstruction over optional delayed reconstruction for {ACL} tears: {Registry} enriched randomised controlled trial data.},\n\tvolume = {50},\n\tcopyright = {Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/},\n\tissn = {1473-0480 0306-3674},\n\turl = {http://dx.doi.org/10.1136/bjsports-2015-095308},\n\tdoi = {10.1136/bjsports-2015-095308},\n\tabstract = {BACKGROUND: To analyse 5-year cost-effectiveness of early versus optional delayed acute anterior cruciate ligament (ACL) reconstruction. METHODS: 121 young, active adults with acute ACL injury to a previously uninjured knee were randomised to early ACL reconstruction (n=62, within 10 weeks of injury) or optional delayed ACL reconstruction (n=59; 30 with ACL reconstruction within 6-55 months); all patients received similar structured rehabilitation. Real life data on health care utilisation and sick leave were obtained from regional and national registers. Costs and quality-adjusted life years (QALYs) were discounted at 3\\%. Full-analysis set (based on study randomisation) and as-treated analysis (according to actual treatment over 5 years) principles were applied. RESULTS: Mean cost of early ACL reconstruction was euro4695 higher than optional delayed ACL reconstruction (p=0.19) and provided an additional 0.13 QALYs (p=0.11). Full-analysis set showed incremental net benefit of early versus optional delayed ACL reconstruction was not statistically significantly different from zero at any level. As-treated analysis showed that costs for rehabilitation alone were euro13 650 less than early ACL reconstruction (p{\\textless}0.001). Results were robust to sensitivity analyses. CONCLUSIONS: In young active adults with acute ACL injury, a strategy of early ACL reconstruction did not provide extra economic value over a strategy of optional delayed ACL reconstruction over a 5-year period. 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