@article{magnusson_nature_2019,
	title = {Nature vs. nurture in knee osteoarthritis - the importance of age, sex and body mass index},
	volume = {27},
	issn = {1522-9653},
	url = {https://doi.org/10.1016%2Fj.joca.2018.12.018},
	doi = {10.1016/j.joca.2018.12.018},
	abstract = {OBJECTIVE: 1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and 2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI).
METHODS: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62 490 twins aged 35 years or older with a follow-up period of up to 47 years (10 092 identical and 21 153 non-identical twin pairs, 54\% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. We also studied the sex-specific heritability across strata of the median BMI to explore any interactions with BMI.
RESULTS: The overall heritability of knee OA surgery was 0.53 (95\% CI=0.31-0.75), with higher heritability among women (H2=0.80 (95\% CI=0.73-0.87)) than men (H2=0.39 (95\% CI=0.10-0.69)). For men, the heritability started to rise after age 68.The genetic contribution was particularly low in men above median BMI (H2≥23.7 kg/m2 =0.08, 95\% CI=-0.32-0.48). For women, the heritability was consistently high from age 50 to death, independently of BMI (H2≥22.5 kg/m2 =0.77, 95\% CI=0.66-0.87).
CONCLUSION: There is a higher and more consistent genetic contribution for knee OA surgery in women than men. In men the genetic contribution was relatively low and varied with age and BMI.},
	language = {eng},
	number = {4},
	journal = {Osteoarthritis and Cartilage},
	author = {Magnusson, Karin and Turkiewicz, Aleksandra and Englund, Martin},
	year = {2019},
	pmid = {30634033},
	keywords = {Knee osteoarthritis, gene-environment interaction, genetics, heritability},
	pages = {586--592},
}

{"_id":"ytjyQ9xXEXoPQzQC6","bibbaseid":"magnusson-turkiewicz-englund-naturevsnurtureinkneeosteoarthritistheimportanceofagesexandbodymassindex-2019","author_short":["Magnusson, K.","Turkiewicz, A.","Englund, M."],"bibdata":{"bibtype":"article","type":"article","title":"Nature vs. nurture in knee osteoarthritis - the importance of age, sex and body mass index","volume":"27","issn":"1522-9653","url":"https://doi.org/10.1016%2Fj.joca.2018.12.018","doi":"10.1016/j.joca.2018.12.018","abstract":"OBJECTIVE: 1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and 2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI). METHODS: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62 490 twins aged 35 years or older with a follow-up period of up to 47 years (10 092 identical and 21 153 non-identical twin pairs, 54% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. We also studied the sex-specific heritability across strata of the median BMI to explore any interactions with BMI. RESULTS: The overall heritability of knee OA surgery was 0.53 (95% CI=0.31-0.75), with higher heritability among women (H2=0.80 (95% CI=0.73-0.87)) than men (H2=0.39 (95% CI=0.10-0.69)). For men, the heritability started to rise after age 68.The genetic contribution was particularly low in men above median BMI (H2≥23.7 kg/m2 =0.08, 95% CI=-0.32-0.48). For women, the heritability was consistently high from age 50 to death, independently of BMI (H2≥22.5 kg/m2 =0.77, 95% CI=0.66-0.87). CONCLUSION: There is a higher and more consistent genetic contribution for knee OA surgery in women than men. In men the genetic contribution was relatively low and varied with age and BMI.","language":"eng","number":"4","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Magnusson"],"firstnames":["Karin"],"suffixes":[]},{"propositions":[],"lastnames":["Turkiewicz"],"firstnames":["Aleksandra"],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["Martin"],"suffixes":[]}],"year":"2019","pmid":"30634033","keywords":"Knee osteoarthritis, gene-environment interaction, genetics, heritability","pages":"586–592","bibtex":"@article{magnusson_nature_2019,\n\ttitle = {Nature vs. nurture in knee osteoarthritis - the importance of age, sex and body mass index},\n\tvolume = {27},\n\tissn = {1522-9653},\n\turl = {https://doi.org/10.1016%2Fj.joca.2018.12.018},\n\tdoi = {10.1016/j.joca.2018.12.018},\n\tabstract = {OBJECTIVE: 1) To estimate the life-time genetic contribution for knee osteoarthritis (OA) surgery and 2) to explore any differences in the genetic contribution across age, sex and body mass index (BMI).\nMETHODS: We studied the sex-specific genetic contribution to knee OA surgery in a prospective cohort study of 62 490 twins aged 35 years or older with a follow-up period of up to 47 years (10 092 identical and 21 153 non-identical twin pairs, 54\\% women). To study interactions with age, we graphed the heritabilities over the lifespan for men and women. We also studied the sex-specific heritability across strata of the median BMI to explore any interactions with BMI.\nRESULTS: The overall heritability of knee OA surgery was 0.53 (95\\% CI=0.31-0.75), with higher heritability among women (H2=0.80 (95\\% CI=0.73-0.87)) than men (H2=0.39 (95\\% CI=0.10-0.69)). For men, the heritability started to rise after age 68.The genetic contribution was particularly low in men above median BMI (H2≥23.7 kg/m2 =0.08, 95\\% CI=-0.32-0.48). For women, the heritability was consistently high from age 50 to death, independently of BMI (H2≥22.5 kg/m2 =0.77, 95\\% CI=0.66-0.87).\nCONCLUSION: There is a higher and more consistent genetic contribution for knee OA surgery in women than men. In men the genetic contribution was relatively low and varied with age and BMI.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Magnusson, Karin and Turkiewicz, Aleksandra and Englund, Martin},\n\tyear = {2019},\n\tpmid = {30634033},\n\tkeywords = {Knee osteoarthritis, gene-environment interaction, genetics, heritability},\n\tpages = {586--592},\n}\n\n","author_short":["Magnusson, K.","Turkiewicz, A.","Englund, M."],"key":"magnusson_nature_2019","id":"magnusson_nature_2019","bibbaseid":"magnusson-turkiewicz-englund-naturevsnurtureinkneeosteoarthritistheimportanceofagesexandbodymassindex-2019","role":"author","urls":{"Paper":"https://doi.org/10.1016%2Fj.joca.2018.12.018"},"keyword":["Knee osteoarthritis","gene-environment interaction","genetics","heritability"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/2575433/items?key=DE7AwkgUPeLruRBgvUzdo0Xc&format=bibtex&limit=100","dataSources":["QDub7pfxdk2ms2NxS","5jEuhQhgRx3py8LmG"],"keywords":["knee osteoarthritis","gene-environment interaction","genetics","heritability"],"search_terms":["nature","nurture","knee","osteoarthritis","importance","age","sex","body","mass","index","magnusson","turkiewicz","englund"],"title":"Nature vs. nurture in knee osteoarthritis - the importance of age, sex and body mass index","year":2019}