Modulated growth, stability and interactions of liquid-like coacervate assemblies of elastin. Muiznieks, L., Cirulis, J., van der Horst, A., Reinhardt, D., Wuite, G., Pomès, R., & Keeley, F. Matrix Biology, 2014.
doi  abstract   bibtex   
© 2014. Elastin self-assembles from monomers into polymer networks that display elasticity and resilience. The first major step in assembly is a liquid-liquid phase separation known as coacervation. This process represents a continuum of stages from initial phase separation to early growth of droplets by coalescence and later "maturation" leading to fiber formation. Assembly of tropoelastin-rich globules is on pathway for fiber formation in vivo. However, little is known about these intermediates beyond their size distribution. Here we investigate the contribution of sequence and structural motifs from full-length tropoelastin and a set of elastin-like polypeptides to the maturation of coacervate assemblies, observing their growth, stability and interaction behavior, and polypeptide alignment within matured globules. We conclude that maturation is driven by surface properties, leading to stabilization of the interface between the hydrophobic interior and aqueous solvent, potentially through structural motifs, and discuss implications for droplet interactions in fiber formation.
@article{
 title = {Modulated growth, stability and interactions of liquid-like coacervate assemblies of elastin},
 type = {article},
 year = {2014},
 keywords = {Colloid,Elastin,Interface,Phase separation,Self-assembly},
 volume = {36},
 id = {dbad3f94-1340-3568-baf8-9244a72952c1},
 created = {2018-06-08T17:39:28.103Z},
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 profile_id = {0633c91d-b6d5-3fcd-9fa3-6021f99f2c58},
 last_modified = {2018-06-08T17:39:28.103Z},
 read = {false},
 starred = {false},
 authored = {true},
 confirmed = {false},
 hidden = {false},
 private_publication = {false},
 abstract = {© 2014. Elastin self-assembles from monomers into polymer networks that display elasticity and resilience. The first major step in assembly is a liquid-liquid phase separation known as coacervation. This process represents a continuum of stages from initial phase separation to early growth of droplets by coalescence and later "maturation" leading to fiber formation. Assembly of tropoelastin-rich globules is on pathway for fiber formation in vivo. However, little is known about these intermediates beyond their size distribution. Here we investigate the contribution of sequence and structural motifs from full-length tropoelastin and a set of elastin-like polypeptides to the maturation of coacervate assemblies, observing their growth, stability and interaction behavior, and polypeptide alignment within matured globules. We conclude that maturation is driven by surface properties, leading to stabilization of the interface between the hydrophobic interior and aqueous solvent, potentially through structural motifs, and discuss implications for droplet interactions in fiber formation.},
 bibtype = {article},
 author = {Muiznieks, L.D. and Cirulis, J.T. and van der Horst, A. and Reinhardt, D.P. and Wuite, G.J.L. and Pomès, R. and Keeley, F.W.},
 doi = {10.1016/j.matbio.2014.03.008},
 journal = {Matrix Biology}
}
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