{"_id":"Z9g6od7w2k5KghbpF","bibbaseid":"schamm-couvrat-malpeli-dudognon-delbreilh-dupray-dargent-coquerel-transformationofanactivepharmaceuticalingredientuponhighenergymillingaprocessinduceddisorderinbiclotymol-2016","downloads":0,"creationDate":"2016-01-14T17:40:37.902Z","title":"Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol","author_short":["Schammé, B.","Couvrat, N.","Malpeli, P.","Dudognon, E.","Delbreilh, L.","Dupray, V.","Dargent, É.","Coquerel, G."],"year":2016,"bibtype":"article","biburl":"https://api.zotero.org/users/1945697/collections/U68KK7N9/items?key=7SLanHA9r9BiESqlMZNOZsrT&format=bibtex&limit=100","bibdata":{"bibtype":"article","type":"article","title":"Transformation of an active pharmaceutical ingredient upon high-energy milling: A process-induced disorder in Biclotymol","volume":"499","issn":"0378-5173","shorttitle":"Transformation of an active pharmaceutical ingredient upon high-energy milling","url":"http://www.sciencedirect.com/science/article/pii/S0378517315304348","doi":"10.1016/j.ijpharm.2015.12.032","abstract":"This study investigates for the first time the thermodynamic changes of Biclotymol upon high-energy milling at various levels of temperature above and below its glass transition temperature (Tg). Investigations have been carried out by temperature modulated differential scanning calorimetry (TM-DSC) and X-ray powder diffraction (XRPD). Results indicate that Biclotymol undergoes a solid-state amorphization upon milling at Tg – 45 °C. It is shown that recrystallization of amorphous milled Biclotymol occurs below the glass transition temperature of Biclotymol (Tg = 20 °C). This displays molecular mobility differences between milled Biclotymol and quenched liquid. A systematic study at several milling temperatures is performed and the implication of Tg in the solid-state transformations generally observed upon milling is discussed. Influence of analysis temperature with respect to interpretation of results was investigated. Finally, it is shown that co-milling Biclotymol with only 20 wt% of amorphous PVP allows a stable amorphous dispersion during at least 5 months of storage.","number":"1–2","urldate":"2016-01-14","journal":"International Journal of Pharmaceutics","author":[{"propositions":[],"lastnames":["Schammé"],"firstnames":["Benjamin"],"suffixes":[]},{"propositions":[],"lastnames":["Couvrat"],"firstnames":["Nicolas"],"suffixes":[]},{"propositions":[],"lastnames":["Malpeli"],"firstnames":["Pascal"],"suffixes":[]},{"propositions":[],"lastnames":["Dudognon"],"firstnames":["Emeline"],"suffixes":[]},{"propositions":[],"lastnames":["Delbreilh"],"firstnames":["Laurent"],"suffixes":[]},{"propositions":[],"lastnames":["Dupray"],"firstnames":["Valérie"],"suffixes":[]},{"propositions":[],"lastnames":["Dargent"],"firstnames":["Éric"],"suffixes":[]},{"propositions":[],"lastnames":["Coquerel"],"firstnames":["Gérard"],"suffixes":[]}],"year":"2016","keywords":"Amorphous, Biclotymol, Glass transition, Milling, Pharmaceuticals, Polyvinylpyrrolidone, Stability","pages":"67–73","bibtex":"@article{schamme_transformation_2016,\n\ttitle = {Transformation of an active pharmaceutical ingredient upon high-energy milling: {A} process-induced disorder in {Biclotymol}},\n\tvolume = {499},\n\tissn = {0378-5173},\n\tshorttitle = {Transformation of an active pharmaceutical ingredient upon high-energy milling},\n\turl = {http://www.sciencedirect.com/science/article/pii/S0378517315304348},\n\tdoi = {10.1016/j.ijpharm.2015.12.032},\n\tabstract = {This study investigates for the first time the thermodynamic changes of Biclotymol upon high-energy milling at various levels of temperature above and below its glass transition temperature (Tg). Investigations have been carried out by temperature modulated differential scanning calorimetry (TM-DSC) and X-ray powder diffraction (XRPD). Results indicate that Biclotymol undergoes a solid-state amorphization upon milling at Tg – 45 °C. It is shown that recrystallization of amorphous milled Biclotymol occurs below the glass transition temperature of Biclotymol (Tg = 20 °C). This displays molecular mobility differences between milled Biclotymol and quenched liquid. A systematic study at several milling temperatures is performed and the implication of Tg in the solid-state transformations generally observed upon milling is discussed. Influence of analysis temperature with respect to interpretation of results was investigated. Finally, it is shown that co-milling Biclotymol with only 20 wt\\% of amorphous PVP allows a stable amorphous dispersion during at least 5 months of storage.},\n\tnumber = {1–2},\n\turldate = {2016-01-14},\n\tjournal = {International Journal of Pharmaceutics},\n\tauthor = {Schammé, Benjamin and Couvrat, Nicolas and Malpeli, Pascal and Dudognon, Emeline and Delbreilh, Laurent and Dupray, Valérie and Dargent, Éric and Coquerel, Gérard},\n\tyear = {2016},\n\tkeywords = {Amorphous, Biclotymol, Glass transition, Milling, Pharmaceuticals, Polyvinylpyrrolidone, Stability},\n\tpages = {67--73}\n}\n\n","author_short":["Schammé, B.","Couvrat, N.","Malpeli, P.","Dudognon, E.","Delbreilh, L.","Dupray, V.","Dargent, É.","Coquerel, G."],"key":"schamme_transformation_2016","id":"schamme_transformation_2016","bibbaseid":"schamm-couvrat-malpeli-dudognon-delbreilh-dupray-dargent-coquerel-transformationofanactivepharmaceuticalingredientuponhighenergymillingaprocessinduceddisorderinbiclotymol-2016","role":"author","urls":{"Paper":"http://www.sciencedirect.com/science/article/pii/S0378517315304348"},"keyword":["Amorphous","Biclotymol","Glass transition","Milling","Pharmaceuticals","Polyvinylpyrrolidone","Stability"],"downloads":0},"search_terms":["transformation","active","pharmaceutical","ingredient","upon","high","energy","milling","process","induced","disorder","biclotymol","schammé","couvrat","malpeli","dudognon","delbreilh","dupray","dargent","coquerel"],"keywords":["amorphous","biclotymol","glass transition","milling","pharmaceuticals","polyvinylpyrrolidone","stability"],"authorIDs":[],"dataSources":["D9umoxGHAE8PaxPy5"]}