Co-infection alters population dynamics of infectious disease. Susi, H., Barrès, B., Vale, P. F., & Laine, A. Nature Communications, 6:5975, January, 2015. ![Co-infection alters population dynamics of infectious disease [pdf]](https://bibbase.org/img/filetypes/pdf.svg "pdf")
Paper doi abstract bibtex 2 downloads Co-infections by multiple pathogen strains are common in the wild. Theory predicts co-infections to have major consequences for both within- and between-host disease dynamics, but data are currently scarce. Here, using common garden populations of Plantago lanceolata infected by two strains of the pathogen Podosphaera plantaginis, either singly or under co-infection, we find the highest disease prevalence in co-infected treatments both at the host genotype and population levels. A spore-trapping experiment demonstrates that co-infected hosts shed more transmission propagules than singly infected hosts, thereby explaining the observed change in epidemiological dynamics. Our experimental findings are confirmed in natural pathogen populations-more devastating epidemics were measured in populations with higher levels of co-infection. Jointly, our results confirm the predictions made by theoretical and experimental studies for the potential of co-infection to alter disease dynamics across a large host-pathogen metapopulation.
@article{susi_co-infection_2015,
title = {Co-infection alters population dynamics of infectious disease},
volume = {6},
issn = {2041-1723},
url = {https://www.nature.com/articles/ncomms6975.pdf},
doi = {10.1038/ncomms6975},
abstract = {Co-infections by multiple pathogen strains are common in the wild. Theory predicts co-infections to have major consequences for both within- and between-host disease dynamics, but data are currently scarce. Here, using common garden populations of Plantago lanceolata infected by two strains of the pathogen Podosphaera plantaginis, either singly or under co-infection, we find the highest disease prevalence in co-infected treatments both at the host genotype and population levels. A spore-trapping experiment demonstrates that co-infected hosts shed more transmission propagules than singly infected hosts, thereby explaining the observed change in epidemiological dynamics. Our experimental findings are confirmed in natural pathogen populations-more devastating epidemics were measured in populations with higher levels of co-infection. Jointly, our results confirm the predictions made by theoretical and experimental studies for the potential of co-infection to alter disease dynamics across a large host-pathogen metapopulation.},
language = {eng},
journal = {Nature Communications},
author = {Susi, Hanna and Barrès, Benoit and Vale, Pedro F. and Laine, Anna-Liisa},
month = jan,
year = {2015},
keywords = {2. Heterogeneity in pathogen transmission},
pages = {5975},
}
Downloads: 2
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