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\n  \n 2014\n \n \n (3)\n \n \n
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\n \n\n \n \n \n \n \n \n An Evolutionarily Conserved Alternate Metal Ligand is Important for Activity in α-Isopropylmalate Synthase from Mycobacterium tuberculosis.\n \n \n \n \n\n\n \n Frantom, P. A.; Birman, Y.; Hays, B. N.; and Casey, A. K.\n\n\n \n\n\n\n Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1844(10): 1784–1789. October 2014.\n \n\n\n\n
\n\n\n\n \n \n \"AnPaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n \n \n \n \n \n \n \n \n\n\n\n
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@article{frantom_evolutionarily_2014,\n\ttitle = {An {Evolutionarily} {Conserved} {Alternate} {Metal} {Ligand} is {Important} for {Activity} in α-{Isopropylmalate} {Synthase} from {Mycobacterium} tuberculosis},\n\tvolume = {1844},\n\tissn = {1570-9639},\n\turl = {http://www.sciencedirect.com/science/article/pii/S1570963914001873},\n\tdoi = {10.1016/j.bbapap.2014.07.013},\n\tnumber = {10},\n\tjournal = {Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics},\n\tauthor = {Frantom, Patrick A. and Birman, Yuliya and Hays, Brittani N. and Casey, Ashley K.},\n\tmonth = oct,\n\tyear = {2014},\n\tkeywords = {DRE-TIM metallolyase superfamily, Enzyme catalysis, Isopropylmalate synthase, Metalloenzyme},\n\tpages = {1784--1789},\n}\n\n
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\n \n\n \n \n \n \n \n \n Evolutionarily Distinct Versions of the Multidomain Enzyme α-Isopropylmalate Synthase Share Discrete Mechanisms of V-Type Allosteric Regulation.\n \n \n \n \n\n\n \n Kumar, G.; and Frantom, P. A.\n\n\n \n\n\n\n Biochemistry, 53(29): 4847–4856. July 2014.\n \n\n\n\n
\n\n\n\n \n \n \"EvolutionarilyPaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{kumar_evolutionarily_2014,\n\ttitle = {Evolutionarily {Distinct} {Versions} of the {Multidomain} {Enzyme} α-{Isopropylmalate} {Synthase} {Share} {Discrete} {Mechanisms} of {V}-{Type} {Allosteric} {Regulation}},\n\tvolume = {53},\n\tissn = {0006-2960},\n\turl = {http://dx.doi.org/10.1021/bi500702u},\n\tdoi = {10.1021/bi500702u},\n\tnumber = {29},\n\tjournal = {Biochemistry},\n\tauthor = {Kumar, Garima and Frantom, Patrick A.},\n\tmonth = jul,\n\tyear = {2014},\n\tpages = {4847--4856},\n}\n\n
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\n \n\n \n \n \n \n \n Mechanistic and Bioinformatic Investigation of a Conserved Active Site Helix in α‑Isopropylmalate Synthase from Mycobacterium tuberculosis, a Member of the DRE-TIM Metallolyase Superfamily.\n \n \n \n\n\n \n Ashley K. Casey; Michael A. Hicks; Jordyn L. Johnson; Patricia C. Babbitt; and Patrick A. Frantom\n\n\n \n\n\n\n Biochemistry, 53: 4847–4856. 2014.\n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{ashley_k._casey_mechanistic_2014,\n\ttitle = {Mechanistic and {Bioinformatic} {Investigation} of a {Conserved} {Active} {Site} {Helix} in α‑{Isopropylmalate} {Synthase} from {Mycobacterium} tuberculosis, a {Member} of the {DRE}-{TIM} {Metallolyase} {Superfamily}},\n\tvolume = {53},\n\tjournal = {Biochemistry},\n\tauthor = {{Ashley K. Casey} and {Michael A. Hicks} and {Jordyn L. Johnson} and {Patricia C. Babbitt} and {Patrick A. Frantom}},\n\tyear = {2014},\n\tpages = {4847--4856},\n}\n
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\n  \n 2012\n \n \n (2)\n \n \n
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\n \n\n \n \n \n \n \n \n Structural and functional characterization of α-isopropylmalate synthase and citramalate synthase, members of the LeuA dimer superfamily.\n \n \n \n \n\n\n \n Frantom, P. A.\n\n\n \n\n\n\n Allosteric Regulation, 519(2): 202–209. March 2012.\n \n\n\n\n
\n\n\n\n \n \n \"StructuralPaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n
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@article{frantom_structural_2012,\n\ttitle = {Structural and functional characterization of α-isopropylmalate synthase and citramalate synthase, members of the {LeuA} dimer superfamily},\n\tvolume = {519},\n\tissn = {0003-9861},\n\turl = {http://www.sciencedirect.com/science/article/pii/S0003986111003468},\n\tdoi = {10.1016/j.abb.2011.10.009},\n\tnumber = {2},\n\tjournal = {Allosteric Regulation},\n\tauthor = {Frantom, Patrick A.},\n\tmonth = mar,\n\tyear = {2012},\n\tkeywords = {Allosteric regulation, Branched chain amino acid biosynthesis, Citramalate synthase, Hydrogen/deuterium exchange, Isopropylmalate synthase, LeuA dimer domain},\n\tpages = {202--209},\n}\n\n
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\n \n\n \n \n \n \n \n \n The Slow-Onset Nature of Allosteric Inhibition in α-Isopropylmalate Synthase from Mycobacterium tuberculosis Is Mediated by a Flexible Loop.\n \n \n \n \n\n\n \n Casey, A. K.; Baugh, J.; and Frantom, P. A.\n\n\n \n\n\n\n Biochemistry, 51(24): 4773–4775. June 2012.\n \n\n\n\n
\n\n\n\n \n \n \"ThePaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{casey_slow-onset_2012,\n\ttitle = {The {Slow}-{Onset} {Nature} of {Allosteric} {Inhibition} in α-{Isopropylmalate} {Synthase} from {Mycobacterium} tuberculosis {Is} {Mediated} by a {Flexible} {Loop}},\n\tvolume = {51},\n\tissn = {0006-2960},\n\turl = {http://dx.doi.org/10.1021/bi300671u},\n\tdoi = {10.1021/bi300671u},\n\tnumber = {24},\n\tjournal = {Biochemistry},\n\tauthor = {Casey, Ashley K. and Baugh, Joshua and Frantom, Patrick A.},\n\tmonth = jun,\n\tyear = {2012},\n\tpages = {4773--4775},\n}\n\n
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\n  \n 2010\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n \n UDP-(5F)-GlcNAc Acts as a Slow-Binding Inhibitor of MshA, a Retaining Glycosyltransferase.\n \n \n \n \n\n\n \n Frantom, P. A.; Coward, J. K.; and Blanchard, J. S.\n\n\n \n\n\n\n Journal of the American Chemical Society, 132(19): 6626–6627. May 2010.\n \n\n\n\n
\n\n\n\n \n \n \"UDP-(5F)-GlcNAcPaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{frantom_udp-5f-glcnac_2010,\n\ttitle = {{UDP}-({5F})-{GlcNAc} {Acts} as a {Slow}-{Binding} {Inhibitor} of {MshA}, a {Retaining} {Glycosyltransferase}},\n\tvolume = {132},\n\tissn = {0002-7863},\n\turl = {http://dx.doi.org/10.1021/ja101231a},\n\tdoi = {10.1021/ja101231a},\n\tnumber = {19},\n\tjournal = {Journal of the American Chemical Society},\n\tauthor = {Frantom, Patrick A. and Coward, James K. and Blanchard, John S.},\n\tmonth = may,\n\tyear = {2010},\n\tpages = {6626--6627},\n}\n\n
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