The IL17A and IL17F loci have divergent histone modifications and are differentially regulated by prostaglandin E2 in Th17 cells. Adamik, J., Henkel, M., Ray, A., Auron, P. E., Duerr, R., & Barrie, A. Cytokine, 64(1):404–412, October, 2013.
doi  abstract   bibtex   
Prostaglandin E2 (PGE2), IL-23 and IL-1beta are implicated in inflammatory bowel disease susceptibility, likely in part by modulating IL-17 producing CD4(+) T helper (Th17) cells. To better understand how these three mediators affect Th17 cell memory responses, we characterized the gene expression profiles of activated human peripheral CD4(+) effector memory T cells and sorted Th17 memory cells from healthy donors concurrent with IL17A mRNA induction mediated by PGE2 and/or IL-23 plus IL-1beta. We discovered that PGE2 and IL-23 plus IL-1beta differentially regulate Th17 cytokine expression and synergize to induce IL-17A, but not IL-17F.
@article{adamik_il17a_2013,
	title = {The {IL17A} and {IL17F} loci have divergent histone modifications and are differentially regulated by prostaglandin {E2} in {Th17} cells.},
	volume = {64},
	copyright = {Copyright (c) 2013 Elsevier Ltd. All rights reserved.},
	issn = {1096-0023 1043-4666},
	doi = {10.1016/j.cyto.2013.05.010},
	abstract = {Prostaglandin E2 (PGE2), IL-23 and IL-1beta are implicated in inflammatory bowel  disease susceptibility, likely in part by modulating IL-17 producing CD4(+) T helper (Th17) cells. To better understand how these three mediators affect Th17 cell memory responses, we characterized the gene expression profiles of activated human peripheral CD4(+) effector memory T cells and sorted Th17 memory cells from healthy donors concurrent with IL17A mRNA induction mediated by PGE2 and/or IL-23 plus IL-1beta. We discovered that PGE2 and IL-23 plus IL-1beta differentially regulate Th17 cytokine expression and synergize to induce IL-17A, but not IL-17F.},
	language = {eng},
	number = {1},
	journal = {Cytokine},
	author = {Adamik, Juraj and Henkel, Matthew and Ray, Anuradha and Auron, Philip E. and Duerr, Richard and Barrie, Arthur},
	month = oct,
	year = {2013},
	pmid = {23800789},
	pmcid = {PMC3770803},
	keywords = {1-OH-PGE1, 1-hydroxy prostaglandin E1, C(T), Cell Line, ChIP, Chromatin, Chromatin/genetics/metabolism, Cyclic AMP/metabolism, E prostanoid, EP, GWAS, Histones/genetics/*metabolism, Humans, IBD, IL-17A, IL-17F, Immunologic Memory/immunology, Interleukin-17/*genetics/metabolism, Interleukin-1beta/metabolism, Interleukin-23/metabolism, PGE2, Prostaglandin E2, Prostaglandins E/metabolism, RNA, Messenger/biosynthesis, Receptors, Prostaglandin E, EP4 Subtype/*metabolism, Signal Transduction/immunology, T helper, Th, Th17, Th17 Cells/immunology/*metabolism, chromatin immunoprecipitation, genome wide association studies, inflammatory bowel disease, prostaglandin E2, threshold cycle},
	pages = {404--412}
}

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