Differential patterns of expression of two novel invertebrate (Lymnaea stagnalis) ionotropic glutamate receptor genes. Harvey, R. J., Stühmer, T., van Minnen, J., & Darlison, M. G. Neuroscience Research Communications, 20(1):31–40, Wiley Online Library, jan, 1997. ![Differential patterns of expression of two novel invertebrate (Lymnaea stagnalis) ionotropic glutamate receptor genes [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex We report the isolation of molluscan (Lymnaea stagnalis) partial complementary DNAs (cDNAs) that encode two new putative glutamate-gated cation-channel polypeptides. These proteins, which we have named Lym-eGluR4 and Lym-eGluR5, exhibit 56% identity to each other, and strong similarity (56% to 61%, and 56% to 68% identity, respectively) to the corresponding portions of vertebrate and invertebrate $α$-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-selective (or AMPA-like) glutamate receptor (GluR) subunits. Using in situ hybridisation, we have shown that the Lym-eGluR4 and Lym-eGluR5 genes are both transcribed in all 11 central ganglia of the molluscan nervous system; however, their patterns of expression are different. Interestingly, the Lym-eGluR5 mRNA is present in an identifiable neuron (RPeD1), within the right pedal ganglion, that has recently been shown to possess a GluR that can be readily activated by L-glutamate, quisqualic acid and kainic acid.
@article{pop00265,
abstract = {We report the isolation of molluscan (Lymnaea stagnalis) partial complementary DNAs (cDNAs) that encode two new putative glutamate-gated cation-channel polypeptides. These proteins, which we have named Lym-eGluR4 and Lym-eGluR5, exhibit 56{\%} identity to each other, and strong similarity (56{\%} to 61{\%}, and 56{\%} to 68{\%} identity, respectively) to the corresponding portions of vertebrate and invertebrate $\alpha$-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-selective (or AMPA-like) glutamate receptor (GluR) subunits. Using in situ hybridisation, we have shown that the Lym-eGluR4 and Lym-eGluR5 genes are both transcribed in all 11 central ganglia of the molluscan nervous system; however, their patterns of expression are different. Interestingly, the Lym-eGluR5 mRNA is present in an identifiable neuron (RPeD1), within the right pedal ganglion, that has recently been shown to possess a GluR that can be readily activated by L-glutamate, quisqualic acid and kainic acid.},
annote = {Query date: 2020-06-29 13:05:30},
author = {Harvey, Robert J. and St{\"{u}}hmer, Thorsten and van Minnen, Jan and Darlison, Mark G.},
doi = {10.1002/(SICI)1520-6769(199701)20:1<31::AID-NRC183>3.0.CO;2-6},
issn = {0893-6609},
journal = {Neuroscience Research Communications},
keywords = {Complementary DNA cloning,Gene family,Glutamate receptor,Glutamate-gated cation channel,In situ hybridisation,Mollusc (Lymnaea stagnalis)},
month = {jan},
number = {1},
pages = {31--40},
publisher = {Wiley Online Library},
title = {{Differential patterns of expression of two novel invertebrate (Lymnaea stagnalis) ionotropic glutamate receptor genes}},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/(SICI)1520-6769(199701)20:1{\%}3C31::AID-NRC183{\%}3E3.0.CO;2-6 http://doi.wiley.com/10.1002/{\%}28SICI{\%}291520-6769{\%}28199701{\%}2920{\%}3A1{\%}3C31{\%}3A{\%}3AAID-NRC183{\%}3E3.0.CO{\%}3B2-6},
volume = {20},
year = {1997}
}
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