@article{lawler_critical_2018,
	title = {Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer},
	volume = {67},
	copyright = {© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/},
	issn = {0017-5749, 1468-3288},
	url = {https://gut.bmj.com/content/67/1/179},
	doi = {10/gcqprk},
	abstract = {Objective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes.
Design RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants.
Results Fifteen critical RGs are summarised below: RG1: Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment; RG2: Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk; RG3: Pressing need for prevention trials; RG4: Lack of integration of different prevention approaches; RG5: Lack of optimal strategies for CRC screening; RG6: Lack of effective triage systems for invasive investigations; RG7: Imprecise pathological assessment of CRC; RG8: Lack of qualified personnel in genomics, data sciences and digital pathology; RG9: Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; RG10: Need for novel technologies/interventions to improve curative outcomes; RG11: Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; RG12: Lack of reliable biomarkers to guide stage IV treatment; RG13: Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution; RG14: Lack of coordination of CRC research/funding; RG15: Lack of effective communication between relevant stakeholders.
Conclusion Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.},
	language = {en},
	number = {1},
	urldate = {2021-10-26},
	journal = {Gut},
	author = {Lawler, Mark and Alsina, Deborah and Adams, Richard A. and Anderson, Annie S. and Brown, Gina and Fearnhead, Nicola S. and Fenwick, Stephen W. and Halloran, Stephen P. and Hochhauser, Daniel and Hull, Mark A. and Koelzer, Viktor H. and McNair, Angus G. K. and Monahan, Kevin J. and Näthke, Inke and Norton, Christine and Novelli, Marco R. and Steele, Robert J. C. and Thomas, Anne L. and Wilde, Lisa M. and Wilson, Richard H. and Tomlinson, Ian},
	month = jan,
	year = {2018},
	pmid = {29233930},
	note = {ZSCC: NoCitationData[s0] 
Publisher: BMJ Publishing Group
Section: Recent advances in clinical practice},
	keywords = {colorectal cancer},
	pages = {179--193},
}

{"_id":"HeJmXokMi2TE8JzTq","bibbaseid":"lawler-alsina-adams-anderson-brown-fearnhead-fenwick-halloran-etal-criticalresearchgapsandrecommendationstoinformresearchprioritisationformoreeffectivepreventionandimprovedoutcomesincolorectalcancer-2018","author_short":["Lawler, M.","Alsina, D.","Adams, R. A.","Anderson, A. S.","Brown, G.","Fearnhead, N. S.","Fenwick, S. W.","Halloran, S. P.","Hochhauser, D.","Hull, M. A.","Koelzer, V. H.","McNair, A. G. K.","Monahan, K. J.","Näthke, I.","Norton, C.","Novelli, M. R.","Steele, R. J. C.","Thomas, A. L.","Wilde, L. M.","Wilson, R. H.","Tomlinson, I."],"bibdata":{"bibtype":"article","type":"article","title":"Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer","volume":"67","copyright":"© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/","issn":"0017-5749, 1468-3288","url":"https://gut.bmj.com/content/67/1/179","doi":"10/gcqprk","abstract":"Objective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. Design RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants. Results Fifteen critical RGs are summarised below: RG1: Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment; RG2: Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk; RG3: Pressing need for prevention trials; RG4: Lack of integration of different prevention approaches; RG5: Lack of optimal strategies for CRC screening; RG6: Lack of effective triage systems for invasive investigations; RG7: Imprecise pathological assessment of CRC; RG8: Lack of qualified personnel in genomics, data sciences and digital pathology; RG9: Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; RG10: Need for novel technologies/interventions to improve curative outcomes; RG11: Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; RG12: Lack of reliable biomarkers to guide stage IV treatment; RG13: Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution; RG14: Lack of coordination of CRC research/funding; RG15: Lack of effective communication between relevant stakeholders. Conclusion Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.","language":"en","number":"1","urldate":"2021-10-26","journal":"Gut","author":[{"propositions":[],"lastnames":["Lawler"],"firstnames":["Mark"],"suffixes":[]},{"propositions":[],"lastnames":["Alsina"],"firstnames":["Deborah"],"suffixes":[]},{"propositions":[],"lastnames":["Adams"],"firstnames":["Richard","A."],"suffixes":[]},{"propositions":[],"lastnames":["Anderson"],"firstnames":["Annie","S."],"suffixes":[]},{"propositions":[],"lastnames":["Brown"],"firstnames":["Gina"],"suffixes":[]},{"propositions":[],"lastnames":["Fearnhead"],"firstnames":["Nicola","S."],"suffixes":[]},{"propositions":[],"lastnames":["Fenwick"],"firstnames":["Stephen","W."],"suffixes":[]},{"propositions":[],"lastnames":["Halloran"],"firstnames":["Stephen","P."],"suffixes":[]},{"propositions":[],"lastnames":["Hochhauser"],"firstnames":["Daniel"],"suffixes":[]},{"propositions":[],"lastnames":["Hull"],"firstnames":["Mark","A."],"suffixes":[]},{"propositions":[],"lastnames":["Koelzer"],"firstnames":["Viktor","H."],"suffixes":[]},{"propositions":[],"lastnames":["McNair"],"firstnames":["Angus","G.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Monahan"],"firstnames":["Kevin","J."],"suffixes":[]},{"propositions":[],"lastnames":["Näthke"],"firstnames":["Inke"],"suffixes":[]},{"propositions":[],"lastnames":["Norton"],"firstnames":["Christine"],"suffixes":[]},{"propositions":[],"lastnames":["Novelli"],"firstnames":["Marco","R."],"suffixes":[]},{"propositions":[],"lastnames":["Steele"],"firstnames":["Robert","J.","C."],"suffixes":[]},{"propositions":[],"lastnames":["Thomas"],"firstnames":["Anne","L."],"suffixes":[]},{"propositions":[],"lastnames":["Wilde"],"firstnames":["Lisa","M."],"suffixes":[]},{"propositions":[],"lastnames":["Wilson"],"firstnames":["Richard","H."],"suffixes":[]},{"propositions":[],"lastnames":["Tomlinson"],"firstnames":["Ian"],"suffixes":[]}],"month":"January","year":"2018","pmid":"29233930","note":"ZSCC: NoCitationData[s0] Publisher: BMJ Publishing Group Section: Recent advances in clinical practice","keywords":"colorectal cancer","pages":"179–193","bibtex":"@article{lawler_critical_2018,\n\ttitle = {Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer},\n\tvolume = {67},\n\tcopyright = {© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/},\n\tissn = {0017-5749, 1468-3288},\n\turl = {https://gut.bmj.com/content/67/1/179},\n\tdoi = {10/gcqprk},\n\tabstract = {Objective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes.\nDesign RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants.\nResults Fifteen critical RGs are summarised below: RG1: Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment; RG2: Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk; RG3: Pressing need for prevention trials; RG4: Lack of integration of different prevention approaches; RG5: Lack of optimal strategies for CRC screening; RG6: Lack of effective triage systems for invasive investigations; RG7: Imprecise pathological assessment of CRC; RG8: Lack of qualified personnel in genomics, data sciences and digital pathology; RG9: Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; RG10: Need for novel technologies/interventions to improve curative outcomes; RG11: Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; RG12: Lack of reliable biomarkers to guide stage IV treatment; RG13: Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution; RG14: Lack of coordination of CRC research/funding; RG15: Lack of effective communication between relevant stakeholders.\nConclusion Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-10-26},\n\tjournal = {Gut},\n\tauthor = {Lawler, Mark and Alsina, Deborah and Adams, Richard A. and Anderson, Annie S. and Brown, Gina and Fearnhead, Nicola S. and Fenwick, Stephen W. and Halloran, Stephen P. and Hochhauser, Daniel and Hull, Mark A. and Koelzer, Viktor H. and McNair, Angus G. K. and Monahan, Kevin J. and Näthke, Inke and Norton, Christine and Novelli, Marco R. and Steele, Robert J. C. and Thomas, Anne L. and Wilde, Lisa M. and Wilson, Richard H. and Tomlinson, Ian},\n\tmonth = jan,\n\tyear = {2018},\n\tpmid = {29233930},\n\tnote = {ZSCC: NoCitationData[s0] \nPublisher: BMJ Publishing Group\nSection: Recent advances in clinical practice},\n\tkeywords = {colorectal cancer},\n\tpages = {179--193},\n}\n\n\n\n\n\n\n\n","author_short":["Lawler, M.","Alsina, D.","Adams, R. A.","Anderson, A. S.","Brown, G.","Fearnhead, N. S.","Fenwick, S. W.","Halloran, S. P.","Hochhauser, D.","Hull, M. A.","Koelzer, V. H.","McNair, A. G. K.","Monahan, K. J.","Näthke, I.","Norton, C.","Novelli, M. R.","Steele, R. J. C.","Thomas, A. L.","Wilde, L. M.","Wilson, R. H.","Tomlinson, I."],"key":"lawler_critical_2018","id":"lawler_critical_2018","bibbaseid":"lawler-alsina-adams-anderson-brown-fearnhead-fenwick-halloran-etal-criticalresearchgapsandrecommendationstoinformresearchprioritisationformoreeffectivepreventionandimprovedoutcomesincolorectalcancer-2018","role":"author","urls":{"Paper":"https://gut.bmj.com/content/67/1/179"},"keyword":["colorectal cancer"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"https://bibbase.org/zotero/nikitaj.greenidge","dataSources":["uXDRqZDxuAtbLLS2T"],"keywords":["colorectal cancer"],"search_terms":["critical","research","gaps","recommendations","inform","research","prioritisation","more","effective","prevention","improved","outcomes","colorectal","cancer","lawler","alsina","adams","anderson","brown","fearnhead","fenwick","halloran","hochhauser","hull","koelzer","mcnair","monahan","näthke","norton","novelli","steele","thomas","wilde","wilson","tomlinson"],"title":"Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer","year":2018}