@article{sparchez_role_2010,
	title = {The role of {Power} {Doppler} ultrasonography in comparison with biological markers in the evaluation of disease activity in {Juvenile} {Idiopathic} {Arthritis}},
	volume = {12},
	issn = {1844-4172},
	abstract = {OBJECTIVE: To evaluate the performance of Power Doppler Ultrasonography (PDUS) compared with biological markers, in the assessment of disease activity in children with Juvenile Idiopathic Arthritis (JIA).
METHODS: Forty hospital visits were studied comprising 32 patients with JIA, during one year of follow-up. Each patient underwent clinical, laboratory and ultrasound (PDUS) evaluation. The physician global assessment score on the visual analog scale (PhGA) was used as a standard for assessing disease activity, based on previous studies. The PDUS signal was scored according to a semiquantitative four grade scale (0-3).
RESULTS: PDUS assessment of synovial vascularisation was more sensitive than erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) in identification of the active disease: 90.4\% vs. 57\% and 28.5\% respectively. CRP had a higher specificity (94\%) in comparison with PDUS (89.5\%). A significant association between clinical examination (PhGA) and PDUS score or ESR was found. Kappa statistics revealed a high level of agreement between PhGA and PDUS score (k=0.799) and a low level of agreement between PhGA and biological markers (k=0.356 and k=0.225 respectively). Patients with higher PDUS score ({\textgreater}or=2), ESR{\textgreater}or=30 mm/h or CRP{\textgreater}or=2 mg/dl were more likely to have active disease.
CONCLUSION: Laboratory tests used today are not sufficiently sensitive for the prediction of active disease. PDUS assessment of synovial vascularisation is a technique with good sensitivity and specificity, thus it may be a beneficial criteria for evaluating disease activity in JIA, completing conventional clinical examination.},
	language = {eng},
	number = {2},
	journal = {Medical Ultrasonography},
	author = {Spârchez, Mihaela and Fodor, Daniela and Miu, Nicolae},
	month = jun,
	year = {2010},
	pmid = {21173935},
	keywords = {Adolescent, Arthritis, Juvenile, Biomarkers, Blood Sedimentation, C-Reactive Protein, Chi-Square Distribution, Child, Child, Preschool, Female, Humans, Infant, Male, Predictive Value of Tests, Sensitivity and Specificity, Ultrasonography, Doppler, Young Adult},
	pages = {97--103}
}

{"_id":"6HptZEhfAPrNGRwRk","bibbaseid":"sprchez-fodor-miu-theroleofpowerdopplerultrasonographyincomparisonwithbiologicalmarkersintheevaluationofdiseaseactivityinjuvenileidiopathicarthritis-2010","downloads":0,"creationDate":"2018-02-19T13:57:38.828Z","title":"The role of Power Doppler ultrasonography in comparison with biological markers in the evaluation of disease activity in Juvenile Idiopathic Arthritis","author_short":["Spârchez, M.","Fodor, D.","Miu, N."],"year":2010,"bibtype":"article","biburl":"http://bibbase.org/zotero/frycow","bibdata":{"bibtype":"article","type":"article","title":"The role of Power Doppler ultrasonography in comparison with biological markers in the evaluation of disease activity in Juvenile Idiopathic Arthritis","volume":"12","issn":"1844-4172","abstract":"OBJECTIVE: To evaluate the performance of Power Doppler Ultrasonography (PDUS) compared with biological markers, in the assessment of disease activity in children with Juvenile Idiopathic Arthritis (JIA). METHODS: Forty hospital visits were studied comprising 32 patients with JIA, during one year of follow-up. Each patient underwent clinical, laboratory and ultrasound (PDUS) evaluation. The physician global assessment score on the visual analog scale (PhGA) was used as a standard for assessing disease activity, based on previous studies. The PDUS signal was scored according to a semiquantitative four grade scale (0-3). RESULTS: PDUS assessment of synovial vascularisation was more sensitive than erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) in identification of the active disease: 90.4% vs. 57% and 28.5% respectively. CRP had a higher specificity (94%) in comparison with PDUS (89.5%). A significant association between clinical examination (PhGA) and PDUS score or ESR was found. Kappa statistics revealed a high level of agreement between PhGA and PDUS score (k=0.799) and a low level of agreement between PhGA and biological markers (k=0.356 and k=0.225 respectively). Patients with higher PDUS score (\\textgreateror=2), ESR\\textgreateror=30 mm/h or CRP\\textgreateror=2 mg/dl were more likely to have active disease. CONCLUSION: Laboratory tests used today are not sufficiently sensitive for the prediction of active disease. PDUS assessment of synovial vascularisation is a technique with good sensitivity and specificity, thus it may be a beneficial criteria for evaluating disease activity in JIA, completing conventional clinical examination.","language":"eng","number":"2","journal":"Medical Ultrasonography","author":[{"propositions":[],"lastnames":["Spârchez"],"firstnames":["Mihaela"],"suffixes":[]},{"propositions":[],"lastnames":["Fodor"],"firstnames":["Daniela"],"suffixes":[]},{"propositions":[],"lastnames":["Miu"],"firstnames":["Nicolae"],"suffixes":[]}],"month":"June","year":"2010","pmid":"21173935","keywords":"Adolescent, Arthritis, Juvenile, Biomarkers, Blood Sedimentation, C-Reactive Protein, Chi-Square Distribution, Child, Child, Preschool, Female, Humans, Infant, Male, Predictive Value of Tests, Sensitivity and Specificity, Ultrasonography, Doppler, Young Adult","pages":"97--103","bibtex":"@article{sparchez_role_2010,\n\ttitle = {The role of {Power} {Doppler} ultrasonography in comparison with biological markers in the evaluation of disease activity in {Juvenile} {Idiopathic} {Arthritis}},\n\tvolume = {12},\n\tissn = {1844-4172},\n\tabstract = {OBJECTIVE: To evaluate the performance of Power Doppler Ultrasonography (PDUS) compared with biological markers, in the assessment of disease activity in children with Juvenile Idiopathic Arthritis (JIA).\nMETHODS: Forty hospital visits were studied comprising 32 patients with JIA, during one year of follow-up. Each patient underwent clinical, laboratory and ultrasound (PDUS) evaluation. The physician global assessment score on the visual analog scale (PhGA) was used as a standard for assessing disease activity, based on previous studies. The PDUS signal was scored according to a semiquantitative four grade scale (0-3).\nRESULTS: PDUS assessment of synovial vascularisation was more sensitive than erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) in identification of the active disease: 90.4\\% vs. 57\\% and 28.5\\% respectively. CRP had a higher specificity (94\\%) in comparison with PDUS (89.5\\%). A significant association between clinical examination (PhGA) and PDUS score or ESR was found. Kappa statistics revealed a high level of agreement between PhGA and PDUS score (k=0.799) and a low level of agreement between PhGA and biological markers (k=0.356 and k=0.225 respectively). Patients with higher PDUS score ({\\textgreater}or=2), ESR{\\textgreater}or=30 mm/h or CRP{\\textgreater}or=2 mg/dl were more likely to have active disease.\nCONCLUSION: Laboratory tests used today are not sufficiently sensitive for the prediction of active disease. PDUS assessment of synovial vascularisation is a technique with good sensitivity and specificity, thus it may be a beneficial criteria for evaluating disease activity in JIA, completing conventional clinical examination.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Medical Ultrasonography},\n\tauthor = {Spârchez, Mihaela and Fodor, Daniela and Miu, Nicolae},\n\tmonth = jun,\n\tyear = {2010},\n\tpmid = {21173935},\n\tkeywords = {Adolescent, Arthritis, Juvenile, Biomarkers, Blood Sedimentation, C-Reactive Protein, Chi-Square Distribution, Child, Child, Preschool, Female, Humans, Infant, Male, Predictive Value of Tests, Sensitivity and Specificity, Ultrasonography, Doppler, Young Adult},\n\tpages = {97--103}\n}\n\n","author_short":["Spârchez, M.","Fodor, D.","Miu, N."],"key":"sparchez_role_2010","id":"sparchez_role_2010","bibbaseid":"sprchez-fodor-miu-theroleofpowerdopplerultrasonographyincomparisonwithbiologicalmarkersintheevaluationofdiseaseactivityinjuvenileidiopathicarthritis-2010","role":"author","urls":{},"keyword":["Adolescent","Arthritis","Juvenile","Biomarkers","Blood Sedimentation","C-Reactive Protein","Chi-Square Distribution","Child","Child","Preschool","Female","Humans","Infant","Male","Predictive Value of Tests","Sensitivity and Specificity","Ultrasonography","Doppler","Young Adult"],"downloads":0,"html":""},"search_terms":["role","power","doppler","ultrasonography","comparison","biological","markers","evaluation","disease","activity","juvenile","idiopathic","arthritis","spârchez","fodor","miu"],"keywords":["adolescent","arthritis","juvenile","biomarkers","blood sedimentation","c-reactive protein","chi-square distribution","child","child","preschool","female","humans","infant","male","predictive value of tests","sensitivity and specificity","ultrasonography","doppler","young adult"],"authorIDs":[],"dataSources":["jg5toQzKuQSdc3Sks"]}