Pharmacological effects of cannabinoids on learning and memory in Lymnaea. Sunada, H., Watanabe, T., Hatakeyama, D., Lee, S., Forest, J., Sakakibara, M., Ito, E., & Lukowiak, K. Journal of Experimental Biology, 220(17):3026–3038, jeb.biologists.org, 2017. ![Pharmacological effects of cannabinoids on learning and memory in Lymnaea [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Cannabinoids are hypothesized to play an important role in modulating learning andmemory formation. Here,we identifiedmRNAs expressed in Lymnaea stagnalis central nervous system that encode two G-protein-coupled receptors (Lymnaea CBr-like 1 and 2) that structurally resemble mammalian cannabinoid receptors (CBrs). We found that injection of a mammalian CBr agonist WIN 55,212-2 (WIN 55) into the snail before operant conditioning obstructed learning and memory formation. This effect of WIN 55 injection persisted for at least 4 days following its injection. A similar obstruction of learning and memory occurred when a severe traumatic stimulus was delivered to L. stagnalis. In contrast, injection of a mammalian CBr antagonist AM 251 enhanced long-term memory formation in snails and reduced the duration of the effects of the severe traumatic stressor on learning and memory. Neither WIN 55 nor AM 251 altered normal homeostatic aerial respiratory behaviour elicited in hypoxic conditions. Our results suggest that putative cannabinoid receptors mediate stressful stimuli that alter learning and memory formation in Lymnaea. This is also the first demonstration that putative CBrs are present in Lymnaea and play a key role in learning and memory formation.
@article{pop00669,
abstract = {Cannabinoids are hypothesized to play an important role in modulating learning andmemory formation. Here,we identifiedmRNAs expressed in Lymnaea stagnalis central nervous system that encode two G-protein-coupled receptors (Lymnaea CBr-like 1 and 2) that structurally resemble mammalian cannabinoid receptors (CBrs). We found that injection of a mammalian CBr agonist WIN 55,212-2 (WIN 55) into the snail before operant conditioning obstructed learning and memory formation. This effect of WIN 55 injection persisted for at least 4 days following its injection. A similar obstruction of learning and memory occurred when a severe traumatic stimulus was delivered to L. stagnalis. In contrast, injection of a mammalian CBr antagonist AM 251 enhanced long-term memory formation in snails and reduced the duration of the effects of the severe traumatic stressor on learning and memory. Neither WIN 55 nor AM 251 altered normal homeostatic aerial respiratory behaviour elicited in hypoxic conditions. Our results suggest that putative cannabinoid receptors mediate stressful stimuli that alter learning and memory formation in Lymnaea. This is also the first demonstration that putative CBrs are present in Lymnaea and play a key role in learning and memory formation.},
annote = {Query date: 2020-06-29 13:05:30},
author = {Sunada, Hiroshi and Watanabe, Takayuki and Hatakeyama, Dai and Lee, Sangmin and Forest, Jeremy and Sakakibara, Manabu and Ito, Etsuro and Lukowiak, Ken},
doi = {10.1242/jeb.159038},
issn = {00220949},
journal = {Journal of Experimental Biology},
keywords = {Aerial respiratory behaviour,Cannabinoid,Long-term memory,Lymnaea stagnalis,Operant conditioning},
number = {17},
pages = {3026--3038},
publisher = {jeb.biologists.org},
title = {{Pharmacological effects of cannabinoids on learning and memory in Lymnaea}},
url = {https://jeb.biologists.org/content/220/17/3026.abstract},
volume = {220},
year = {2017}
}
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A similar obstruction of learning and memory occurred when a severe traumatic stimulus was delivered to L. stagnalis. In contrast, injection of a mammalian CBr antagonist AM 251 enhanced long-term memory formation in snails and reduced the duration of the effects of the severe traumatic stressor on learning and memory. Neither WIN 55 nor AM 251 altered normal homeostatic aerial respiratory behaviour elicited in hypoxic conditions. Our results suggest that putative cannabinoid receptors mediate stressful stimuli that alter learning and memory formation in Lymnaea. This is also the first demonstration that putative CBrs are present in Lymnaea and play a key role in learning and memory formation.","annote":"Query date: 2020-06-29 13:05:30","author":[{"propositions":[],"lastnames":["Sunada"],"firstnames":["Hiroshi"],"suffixes":[]},{"propositions":[],"lastnames":["Watanabe"],"firstnames":["Takayuki"],"suffixes":[]},{"propositions":[],"lastnames":["Hatakeyama"],"firstnames":["Dai"],"suffixes":[]},{"propositions":[],"lastnames":["Lee"],"firstnames":["Sangmin"],"suffixes":[]},{"propositions":[],"lastnames":["Forest"],"firstnames":["Jeremy"],"suffixes":[]},{"propositions":[],"lastnames":["Sakakibara"],"firstnames":["Manabu"],"suffixes":[]},{"propositions":[],"lastnames":["Ito"],"firstnames":["Etsuro"],"suffixes":[]},{"propositions":[],"lastnames":["Lukowiak"],"firstnames":["Ken"],"suffixes":[]}],"doi":"10.1242/jeb.159038","issn":"00220949","journal":"Journal of Experimental Biology","keywords":"Aerial respiratory behaviour,Cannabinoid,Long-term memory,Lymnaea stagnalis,Operant conditioning","number":"17","pages":"3026–3038","publisher":"jeb.biologists.org","title":"Pharmacological effects of cannabinoids on learning and memory in Lymnaea","url":"https://jeb.biologists.org/content/220/17/3026.abstract","volume":"220","year":"2017","bibtex":"@article{pop00669,\nabstract = {Cannabinoids are hypothesized to play an important role in modulating learning andmemory formation. 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