The lymnaea cardioexcitatory peptide (LyCEP) receptor: A G-protein- coupled receptor for a novel member of the RFamide neuropeptide family. Tensen, C. P., Cox, K. J., Smit, A. B., Van Der Schors, R. C., Meyerhof, W., Richter, D., Planta, R. J., Hermann, P. M., Van Minnen, J., Geraerts, W. P., Knol, J. C., Burke, J. F., Vreugdenhil, E., & Van Heerikhuizen, H. Journal of Neuroscience, 18(23):9812–9821, Soc Neuroscience, 1998. ![The lymnaea cardioexcitatory peptide (LyCEP) receptor: A G-protein- coupled receptor for a novel member of the RFamide neuropeptide family [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex A novel G-protein-coupled receptor (GRL106) resembling neuropeptide Y and tachykinin receptors was cloned from the mollusc Lymnaea stagnalis. Application of a peptide extract from the Lymnaea brain to Xenopus oocytes expressing GRL106 activated a calcium-dependent chloride channel. Using this response as a bioassay, we purified the ligand for GRL106, Lymnaea cardioexcitatory peptide (LyCEP), an RFamide-type decapeptide (TPHWRPQGRF- NH2) displaying significant similarity to the Achatina cardioexcitatory peptide (ACEP-1) as well as to the recently identified family of mammalian prolactin-releasing peptides. In the Lymnaea brain, the cells that produce egg-laying hormone are the predominant site of GRL106 gene expression and appear to be innervated by LyCEP-containing fibers. Indeed, LyCEP application transiently hyperpolarizes isolated egg-laying hormone cells. In the Lymnaea pericardium, LyCEP-containing fibers end blindly at the pericardial lumen, and the heart is stimulated by LyCEP in vitro. These data confirm that LyCEP is an RFamide ligand for GRL106.
@article{pop00162,
abstract = {A novel G-protein-coupled receptor (GRL106) resembling neuropeptide Y and tachykinin receptors was cloned from the mollusc Lymnaea stagnalis. Application of a peptide extract from the Lymnaea brain to Xenopus oocytes expressing GRL106 activated a calcium-dependent chloride channel. Using this response as a bioassay, we purified the ligand for GRL106, Lymnaea cardioexcitatory peptide (LyCEP), an RFamide-type decapeptide (TPHWRPQGRF- NH2) displaying significant similarity to the Achatina cardioexcitatory peptide (ACEP-1) as well as to the recently identified family of mammalian prolactin-releasing peptides. In the Lymnaea brain, the cells that produce egg-laying hormone are the predominant site of GRL106 gene expression and appear to be innervated by LyCEP-containing fibers. Indeed, LyCEP application transiently hyperpolarizes isolated egg-laying hormone cells. In the Lymnaea pericardium, LyCEP-containing fibers end blindly at the pericardial lumen, and the heart is stimulated by LyCEP in vitro. These data confirm that LyCEP is an RFamide ligand for GRL106.},
annote = {Query date: 2020-06-29 13:05:30},
author = {Tensen, Cornelis P. and Cox, Kingsley J.A. and Smit, August B. and {Van Der Schors}, Roel C. and Meyerhof, Wolfgang and Richter, Dietmar and Planta, Rudi J. and Hermann, Petra M. and {Van Minnen}, Jan and Geraerts, Wijnand P.M. and Knol, Jaco C. and Burke, Julian F. and Vreugdenhil, Erno and {Van Heerikhuizen}, Harm},
doi = {10.1523/JNEUROSCI.18-23-09812.1998},
issn = {02706474},
journal = {Journal of Neuroscience},
keywords = {HPLC,Mollusc,Neuropeptide receptor,Orphan receptor,RFamide,Xenopus oocyte},
number = {23},
pages = {9812--9821},
publisher = {Soc Neuroscience},
title = {{The lymnaea cardioexcitatory peptide (LyCEP) receptor: A G-protein- coupled receptor for a novel member of the RFamide neuropeptide family}},
url = {https://www.jneurosci.org/content/18/23/9812.short},
volume = {18},
year = {1998}
}
Downloads: 0
{"_id":"eucNroCdEZZGzRzwp","bibbaseid":"tensen-cox-smit-vanderschors-meyerhof-richter-planta-hermann-etal-thelymnaeacardioexcitatorypeptidelycepreceptoragproteincoupledreceptorforanovelmemberoftherfamideneuropeptidefamily-1998","author_short":["Tensen, C. P.","Cox, K. J.","Smit, A. B.","Van Der Schors, R. C.","Meyerhof, W.","Richter, D.","Planta, R. J.","Hermann, P. M.","Van Minnen, J.","Geraerts, W. P.","Knol, J. C.","Burke, J. F.","Vreugdenhil, E.","Van Heerikhuizen, H."],"bibdata":{"bibtype":"article","type":"article","abstract":"A novel G-protein-coupled receptor (GRL106) resembling neuropeptide Y and tachykinin receptors was cloned from the mollusc Lymnaea stagnalis. Application of a peptide extract from the Lymnaea brain to Xenopus oocytes expressing GRL106 activated a calcium-dependent chloride channel. Using this response as a bioassay, we purified the ligand for GRL106, Lymnaea cardioexcitatory peptide (LyCEP), an RFamide-type decapeptide (TPHWRPQGRF- NH2) displaying significant similarity to the Achatina cardioexcitatory peptide (ACEP-1) as well as to the recently identified family of mammalian prolactin-releasing peptides. In the Lymnaea brain, the cells that produce egg-laying hormone are the predominant site of GRL106 gene expression and appear to be innervated by LyCEP-containing fibers. Indeed, LyCEP application transiently hyperpolarizes isolated egg-laying hormone cells. In the Lymnaea pericardium, LyCEP-containing fibers end blindly at the pericardial lumen, and the heart is stimulated by LyCEP in vitro. These data confirm that LyCEP is an RFamide ligand for GRL106.","annote":"Query date: 2020-06-29 13:05:30","author":[{"propositions":[],"lastnames":["Tensen"],"firstnames":["Cornelis","P."],"suffixes":[]},{"propositions":[],"lastnames":["Cox"],"firstnames":["Kingsley","J.A."],"suffixes":[]},{"propositions":[],"lastnames":["Smit"],"firstnames":["August","B."],"suffixes":[]},{"propositions":[],"lastnames":["Van Der Schors"],"firstnames":["Roel","C."],"suffixes":[]},{"propositions":[],"lastnames":["Meyerhof"],"firstnames":["Wolfgang"],"suffixes":[]},{"propositions":[],"lastnames":["Richter"],"firstnames":["Dietmar"],"suffixes":[]},{"propositions":[],"lastnames":["Planta"],"firstnames":["Rudi","J."],"suffixes":[]},{"propositions":[],"lastnames":["Hermann"],"firstnames":["Petra","M."],"suffixes":[]},{"propositions":[],"lastnames":["Van Minnen"],"firstnames":["Jan"],"suffixes":[]},{"propositions":[],"lastnames":["Geraerts"],"firstnames":["Wijnand","P.M."],"suffixes":[]},{"propositions":[],"lastnames":["Knol"],"firstnames":["Jaco","C."],"suffixes":[]},{"propositions":[],"lastnames":["Burke"],"firstnames":["Julian","F."],"suffixes":[]},{"propositions":[],"lastnames":["Vreugdenhil"],"firstnames":["Erno"],"suffixes":[]},{"propositions":[],"lastnames":["Van Heerikhuizen"],"firstnames":["Harm"],"suffixes":[]}],"doi":"10.1523/JNEUROSCI.18-23-09812.1998","issn":"02706474","journal":"Journal of Neuroscience","keywords":"HPLC,Mollusc,Neuropeptide receptor,Orphan receptor,RFamide,Xenopus oocyte","number":"23","pages":"9812–9821","publisher":"Soc Neuroscience","title":"The lymnaea cardioexcitatory peptide (LyCEP) receptor: A G-protein- coupled receptor for a novel member of the RFamide neuropeptide family","url":"https://www.jneurosci.org/content/18/23/9812.short","volume":"18","year":"1998","bibtex":"@article{pop00162,\nabstract = {A novel G-protein-coupled receptor (GRL106) resembling neuropeptide Y and tachykinin receptors was cloned from the mollusc Lymnaea stagnalis. Application of a peptide extract from the Lymnaea brain to Xenopus oocytes expressing GRL106 activated a calcium-dependent chloride channel. Using this response as a bioassay, we purified the ligand for GRL106, Lymnaea cardioexcitatory peptide (LyCEP), an RFamide-type decapeptide (TPHWRPQGRF- NH2) displaying significant similarity to the Achatina cardioexcitatory peptide (ACEP-1) as well as to the recently identified family of mammalian prolactin-releasing peptides. In the Lymnaea brain, the cells that produce egg-laying hormone are the predominant site of GRL106 gene expression and appear to be innervated by LyCEP-containing fibers. Indeed, LyCEP application transiently hyperpolarizes isolated egg-laying hormone cells. In the Lymnaea pericardium, LyCEP-containing fibers end blindly at the pericardial lumen, and the heart is stimulated by LyCEP in vitro. These data confirm that LyCEP is an RFamide ligand for GRL106.},\nannote = {Query date: 2020-06-29 13:05:30},\nauthor = {Tensen, Cornelis P. and Cox, Kingsley J.A. and Smit, August B. and {Van Der Schors}, Roel C. and Meyerhof, Wolfgang and Richter, Dietmar and Planta, Rudi J. and Hermann, Petra M. and {Van Minnen}, Jan and Geraerts, Wijnand P.M. and Knol, Jaco C. and Burke, Julian F. and Vreugdenhil, Erno and {Van Heerikhuizen}, Harm},\ndoi = {10.1523/JNEUROSCI.18-23-09812.1998},\nissn = {02706474},\njournal = {Journal of Neuroscience},\nkeywords = {HPLC,Mollusc,Neuropeptide receptor,Orphan receptor,RFamide,Xenopus oocyte},\nnumber = {23},\npages = {9812--9821},\npublisher = {Soc Neuroscience},\ntitle = {{The lymnaea cardioexcitatory peptide (LyCEP) receptor: A G-protein- coupled receptor for a novel member of the RFamide neuropeptide family}},\nurl = {https://www.jneurosci.org/content/18/23/9812.short},\nvolume = {18},\nyear = {1998}\n}\n","author_short":["Tensen, C. P.","Cox, K. J.","Smit, A. B.","Van Der Schors, R. C.","Meyerhof, W.","Richter, D.","Planta, R. J.","Hermann, P. M.","Van Minnen, J.","Geraerts, W. P.","Knol, J. C.","Burke, J. F.","Vreugdenhil, E.","Van Heerikhuizen, H."],"key":"pop00162","id":"pop00162","bibbaseid":"tensen-cox-smit-vanderschors-meyerhof-richter-planta-hermann-etal-thelymnaeacardioexcitatorypeptidelycepreceptoragproteincoupledreceptorforanovelmemberoftherfamideneuropeptidefamily-1998","role":"author","urls":{"Paper":"https://www.jneurosci.org/content/18/23/9812.short"},"keyword":["HPLC","Mollusc","Neuropeptide receptor","Orphan receptor","RFamide","Xenopus oocyte"],"metadata":{"authorlinks":{}},"html":""},"bibtype":"article","biburl":"http://lymnaea.org/data/lymnaeastagnalis-neuroscience.bib","dataSources":["aGHieW6wJ8vBRjMFD"],"keywords":["hplc","mollusc","neuropeptide receptor","orphan receptor","rfamide","xenopus oocyte"],"search_terms":["lymnaea","cardioexcitatory","peptide","lycep","receptor","protein","coupled","receptor","novel","member","rfamide","neuropeptide","family","tensen","cox","smit","van der schors","meyerhof","richter","planta","hermann","van minnen","geraerts","knol","burke","vreugdenhil","van heerikhuizen"],"title":"The lymnaea cardioexcitatory peptide (LyCEP) receptor: A G-protein- coupled receptor for a novel member of the RFamide neuropeptide family","year":1998}