A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction. Tensen, C. P., Van Kesteren, E. R., Planta, R. J., Cox, K. J., Burke, J. F., Van Heerikhuizen, H., & Vreugdenhil, E. Proceedings of the National Academy of Sciences of the United States of America, 91(11):4816–4820, National Acad Sciences, 1994. ![A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex We have isolated and analyzed a cDNA from the central nervous system of the mollusc Lymnaea stagnalis encoding a putative receptor, which might be a natural hybrid between two different classes of receptor proteins. Preceded by a signal peptide, two types of repeated sequences are present in the N- terminal part of the protein. The first repeat displays a high sequence similarity to the extracellular binding domains of the low density lipoprotein receptor, which binds and internalizes cholesterol-containing apolipoproteins. The second repeat and the C-terminal part of the Lymnaea receptor are very similar to regions of a specific class of guanine nucleotide-binding protein-coupled receptors, the mammalian glycoprotein hormone receptors. The mRNA encoding the receptor is predominantly expressed in a small number of neurons within the central nervous system and to a lesser extent in the heart.
@article{pop00716,
abstract = {We have isolated and analyzed a cDNA from the central nervous system of the mollusc Lymnaea stagnalis encoding a putative receptor, which might be a natural hybrid between two different classes of receptor proteins. Preceded by a signal peptide, two types of repeated sequences are present in the N- terminal part of the protein. The first repeat displays a high sequence similarity to the extracellular binding domains of the low density lipoprotein receptor, which binds and internalizes cholesterol-containing apolipoproteins. The second repeat and the C-terminal part of the Lymnaea receptor are very similar to regions of a specific class of guanine nucleotide-binding protein-coupled receptors, the mammalian glycoprotein hormone receptors. The mRNA encoding the receptor is predominantly expressed in a small number of neurons within the central nervous system and to a lesser extent in the heart.},
annote = {Query date: 2020-06-29 13:05:30},
author = {Tensen, Cornelis P. and {Van Kesteren}, Ellen R. and Planta, Rudi J. and Cox, Kingsley J.A. and Burke, Julian F. and {Van Heerikhuizen}, Harm and Vreugdenhil, Erno},
doi = {10.1073/pnas.91.11.4816},
issn = {00278424},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
keywords = {Lymnaea stagnalis,central nervous system,leucine-rich repeats,molluscs},
number = {11},
pages = {4816--4820},
publisher = {National Acad Sciences},
title = {{A G protein-coupled receptor with low density lipoprotein-binding motifs suggests a role for lipoproteins in G-linked signal transduction}},
url = {https://www.pnas.org/content/91/11/4816.short},
volume = {91},
year = {1994}
}
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