A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis. van Kesteren, R. E., Tensen, C. P., Smit, A. B., van Minnen, J., van Soest, P. F., Kits, K. S., Meyerhof, W., Richter, D., van Heerikhuizen, H., Vreugdenhil, E., & Geraerts, W. P. Neuron, 15(4):897–908, 1995.
A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis [link]Paper  doi  abstract   bibtex   
We have cloned a receptor, named LSCPR, for vasopressin-related Lys-conopressin in Lymnaea stagnalis. Lys-conopressin evokes Ca2+-dependent Cl- currents in Xenopus oocytes injected with LSCPR cRNA. Expression of LSCPR mRNA was detected in central neurons and peripheral muscles associated with reproduction. Upon application of Lys-conopressin, both neurons and muscle cells depolarize owing to an enhancement of voltage-dependent Ca2+ currents and start firing action potentials. Some neurons coexpress LSCPR and Lys-conopressin, suggesting an autotransmitter-like function for this peptide. Lysconopressin also induces a depolarizing response in LSCPR-expressing neuroendocrine cells that control carbohydrate metabolism. Thus, in addition to oxytocin-like reproductive functions, LSCPR mediates vasopressin-like metabolic functions of Lys-conopressin as well. \textcopyright 1995.
@article{VanKesteren1995,
abstract = {We have cloned a receptor, named LSCPR, for vasopressin-related Lys-conopressin in Lymnaea stagnalis. Lys-conopressin evokes Ca2+-dependent Cl- currents in Xenopus oocytes injected with LSCPR cRNA. Expression of LSCPR mRNA was detected in central neurons and peripheral muscles associated with reproduction. Upon application of Lys-conopressin, both neurons and muscle cells depolarize owing to an enhancement of voltage-dependent Ca2+ currents and start firing action potentials. Some neurons coexpress LSCPR and Lys-conopressin, suggesting an autotransmitter-like function for this peptide. Lysconopressin also induces a depolarizing response in LSCPR-expressing neuroendocrine cells that control carbohydrate metabolism. Thus, in addition to oxytocin-like reproductive functions, LSCPR mediates vasopressin-like metabolic functions of Lys-conopressin as well. {\textcopyright} 1995.},
author = {van Kesteren, R. E. and Tensen, C. P. and Smit, A. B. and van Minnen, J. and van Soest, P. F. and Kits, K. S. and Meyerhof, W. and Richter, D. and van Heerikhuizen, H. and Vreugdenhil, E. and Geraerts, W. P.M.},
doi = {10.1016/0896-6273(95)90180-9},
issn = {08966273},
journal = {Neuron},
number = {4},
pages = {897--908},
pmid = {7576638},
title = {{A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis}},
url = {https://www.sciencedirect.com/science/article/pii/0896627395901809},
volume = {15},
year = {1995}
}
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