The association between meniscal body extrusion and the development/enlargement of bone marrow lesions on knee MRI in overweight and obese women. Zhang, F., Bierma-Zeinstra, S. M., Oei, E. H. G., Turkiewicz, A., Englund, M., & Runhaar, J. Osteoarthritis and Cartilage Open, November, 2019.
The association between meniscal body extrusion and the development/enlargement of bone marrow lesions on knee MRI in overweight and obese women [link]Paper  doi  abstract   bibtex   
Objective To determine the association between meniscal body extrusion and bone marrow lesion (BML) development/enlargement in overweight and obese women at high risk of knee osteoarthritis (OA). Design We used baseline and 30 months follow-up data of the PROOF study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects (n = 395) completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and repeated 1.5 T MRI of both knees. Using the mid-coronal MRI slice, one observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. BMLs and meniscal damage were read using the semi-quantitative MOAKS scoring system by another observer. The association between BML development and meniscal extrusion was primarily analyzed with a random-effects logistic regression model adjusted for age, body weight, body height, physical activity, meniscus damage, knee alignment, and tibia width. In addition, we used a fixed-effect regression model for evaluation of knee-specific factors. Results In our primary model, there was about 24% increased risk of BML incidence/enlargement per 1 mm extrusion (95% confidence interval [CI] 0.99, 1.57) for medial compartments and 69% risk increase (95% confidence interval [CI] 1.27, 2.25) for the lateral compartments. Results from the fixed-effects regression model were similar, strengthening the validity of the findings. Conclusions Meniscal body extrusion is an important factor influencing BML development/enlargement, and thus may be a potential treatment target in knee OA development.
@article{zhang_association_2019,
	title = {The association between meniscal body extrusion and the development/enlargement of bone marrow lesions on knee {MRI} in overweight and obese women},
	issn = {2665-9131},
	url = {http://www.sciencedirect.com/science/article/pii/S2665913119300184},
	doi = {10.1016/j.ocarto.2019.100015},
	abstract = {Objective
To determine the association between meniscal body extrusion and bone marrow lesion (BML) development/enlargement in overweight and obese women at high risk of knee osteoarthritis (OA).
Design
We used baseline and 30 months follow-up data of the PROOF study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects (n = 395) completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and repeated 1.5 T MRI of both knees. Using the mid-coronal MRI slice, one observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. BMLs and meniscal damage were read using the semi-quantitative MOAKS scoring system by another observer. The association between BML development and meniscal extrusion was primarily analyzed with a random-effects logistic regression model adjusted for age, body weight, body height, physical activity, meniscus damage, knee alignment, and tibia width. In addition, we used a fixed-effect regression model for evaluation of knee-specific factors.
Results
In our primary model, there was about 24\% increased risk of BML incidence/enlargement per 1 mm extrusion (95\% confidence interval [CI] 0.99, 1.57) for medial compartments and 69\% risk increase (95\% confidence interval [CI] 1.27, 2.25) for the lateral compartments. Results from the fixed-effects regression model were similar, strengthening the validity of the findings.
Conclusions
Meniscal body extrusion is an important factor influencing BML development/enlargement, and thus may be a potential treatment target in knee OA development.},
	language = {en},
	urldate = {2019-12-20},
	journal = {Osteoarthritis and Cartilage Open},
	author = {Zhang, Fan and Bierma-Zeinstra, Sita M. and Oei, Edwin H. G. and Turkiewicz, Aleksandra and Englund, Martin and Runhaar, Jos},
	month = nov,
	year = {2019},
	keywords = {Bone marrow lesions, Meniscal extrusion, Overweight women},
	pages = {100015},
}

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