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\n  \n 1. Peer-Reviewed Journal Papers\n \n \n (17)\n \n \n
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\n \n\n \n \n Sweedo, A.; Wise, L. M.; Roka-Moiia, Y.; Teran Arce, F.; Saavedra, S. S.; Sheriff, J.; Bluestein, D.; Slepian, M. J.; and Purdy, J. G.\n\n\n \n \n \n \n \n Shear-Mediated Platelet Activation is Accompanied by Unique Alterations of Platelet Release of Lipids.\n \n \n \n \n\n\n \n\n\n\n Cell Mol Bioeng, 14: 597-612. 2021.\n \n\n\n\n
\n\n\n\n \n \n \"Shear-Mediated link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{a153,\r\n author = {Sweedo, A. and Wise, L. M. and Roka-Moiia, Y. and Teran Arce, F. and Saavedra, S. S. and Sheriff, J. and Bluestein, D. and Slepian, M. J. and Purdy, J. G.},\r\n year = {2021},\r\n title = {Shear-Mediated Platelet Activation is Accompanied by Unique Alterations of Platelet Release of Lipids},\r\n journal = {Cell Mol Bioeng},\r\n volume = {14},\r\n pages = {597-612},\r\n url_Link ={https://doi.org/10.1007/s12195-021-00692-x},\r\n project = {activation},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Ammann, K. R.; Miller-Gutierrez, S.; Sweedo, A.; Palomares, D.; Italiano, J.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n \n Shear-Mediated Platelet Activation in the Free Flow II: Evolving Mechanobiological Mechanisms Reveal an Identifiable Signature of Activation and a Bi-Directional Platelet Dyscrasia with Thrombotic and Bleeding Features.\n \n \n \n \n\n\n \n\n\n\n J Biomech, 123: 110415. 2021.\n \n\n\n\n
\n\n\n\n \n \n \"Shear-Mediated link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n  \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{a141,\r\n author = {Roka-Moiia, Y. and Ammann, K. R. and Miller-Gutierrez, S. and Sweedo, A. and Palomares, D. and Italiano, J. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2021},\r\n title = {Shear-Mediated Platelet Activation in the Free Flow II: Evolving Mechanobiological Mechanisms Reveal an Identifiable Signature of Activation and a Bi-Directional Platelet Dyscrasia with Thrombotic and Bleeding Features},\r\n journal = {J Biomech},\r\n volume = {123},\r\n pages = {110415},\r\n url_Link ={https://doi.org/10.1016/j.jbiomech.2021.110415},\r\n project = {activation},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Miller-Gutierrez, S.; Palomares, D. E.; Italiano, J. E.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n \n Platelet Dysfunction During Mechanical Circulatory Support: Elevated Shear Stress Promotes Downregulation of αIIb β3 and GPIb via Microparticle Shedding Decreasing Platelet Aggregability.\n \n \n \n \n\n\n \n\n\n\n Arterioscler Thromb Vasc Biol, 41: 1319-1336. 2021.\n \n\n\n\n
\n\n\n\n \n \n \"Platelet link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n  \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{a137,\r\n author = {Roka-Moiia, Y. and Miller-Gutierrez, S. and Palomares, D. E. and Italiano, J. E. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2021},\r\n title = {Platelet Dysfunction During Mechanical Circulatory Support: Elevated Shear Stress Promotes Downregulation of αIIb β3 and GPIb via Microparticle Shedding Decreasing Platelet Aggregability},\r\n journal = {Arterioscler Thromb Vasc Biol},\r\n volume = {41},\r\n issue = {4},\r\n pages = {1319-1336},\r\n url_Link ={https://doi.org/10.1161/ATVBAHA.120.315583},\r\n project = {activation},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Malone, L. E.; Avila, C.; Zigomalas, A.; Bluestein, D.; and Bahou, W. F.\n\n\n \n \n \n \n \n Shear-Induced Platelet Activation is Sensitive to Age and Calcium Availability: A Comparison of Adult and Umbilical Cord Blood.\n \n \n \n \n\n\n \n\n\n\n Cell Mol Bioeng, 13: 575-590. 2020.\n \n\n\n\n
\n\n\n\n \n \n \"Shear-Induced link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{a114,\r\n author = {Sheriff, J. and Malone, L. E. and Avila, C. and Zigomalas, A. and Bluestein, D. and Bahou, W. F.},\r\n year = {2020},\r\n title = {Shear-Induced Platelet Activation is Sensitive to Age and Calcium Availability: A Comparison of Adult and Umbilical Cord Blood},\r\n journal = {Cell Mol Bioeng},\r\n volume = {13},\r\n issue = {6},\r\n pages = {575-590},\r\n url_Link ={https://doi.org/10.1007/s12195-020-00628-x},\r\n project = {activation},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Walk, R.; Palomares, D. E.; Ammann, K. R.; Dimasi, A.; Italiano, J. E.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n \n Platelet Activation Via Shear Stress Exposure Induces a Differing Pattern of Biomarkers of Activation Versus Biochemical Agonists.\n \n \n \n \n\n\n \n\n\n\n Thromb Haemost, 120: 776-792. 2020.\n \n\n\n\n
\n\n\n\n \n \n \"Platelet link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
\n 
@article{a113,\r\n author = {Roka-Moiia, Y. and Walk, R. and Palomares, D. E. and Ammann, K. R. and Dimasi, A. and Italiano, J. E. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2020},\r\n title = {Platelet Activation Via Shear Stress Exposure Induces a Differing Pattern of Biomarkers of Activation Versus Biochemical Agonists},\r\n journal = {Thromb Haemost},\r\n volume = {120},\r\n issue = {5},\r\n pages = {776-792},\r\n url_Link ={https://doi.org/10.1055/s-0040-1709524},\r\n project = {activation},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n \n\n \n \n Li, M.; Walk, R.; Roka-Moiia, Y.; Sheriff, J.; Bluestein, D.; Barth, E.; and Slepian, M.\n\n\n \n \n \n \n \n Circulatory Loop Design and Components Introduce Artifacts Impacting In-Vitro Evaluation of Ventricular Assist Device Thrombogenicity: A Call for Caution.\n \n \n \n \n\n\n \n\n\n\n Artif Organs, 44: E226-E237. 2019.\n \n\n\n\n
\n\n\n\n \n \n \"Circulatory link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n  \n \n 7 downloads\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
\n 
@article{a109,\r\n author = {Li, M. and Walk, R. and Roka-Moiia, Y. and Sheriff, J. and Bluestein, D. and Barth, E.J. and Slepian, M.J.},\r\n year = {2019},\r\n title = {Circulatory Loop Design and Components Introduce Artifacts Impacting In-Vitro Evaluation of Ventricular Assist Device Thrombogenicity: A Call for Caution},\r\n journal = {Artif Organs},\r\n volume = {44},\r\n issue = {6},\r\n pages = {E226-E237},\r\n url_Link ={https://doi.org/10.1111/aor.13626},\r\n project = {activation; lvad},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n \n\n \n \n Apostoli, A.; Bianchi, V.; Bono, N.; Dimasi, A.; Ammann, K.; Roka-Moiia, Y.; Montisci, A.; Sheriff, J.; Bluestein, D.; Fiore, G.; Pappalardo, F.; Candiani, G.; Redaelli, A.; Slepian, M.; and Consolo, F.\n\n\n \n \n \n \n \n Prothrombotic Activity of Cytokine-Activated Endothelial Cells and Shear-Activated Platelets in the Setting of Ventricular Assist Device Support.\n \n \n \n \n\n\n \n\n\n\n J Heart Lung Transplant., 38: 658-667. 2019.\n \n\n\n\n
\n\n\n\n \n \n \"Prothrombotic link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n  \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
\n 
@article{a78,\r\n author = {Apostoli, A. and Bianchi, V. and Bono, N. and Dimasi, A. and Ammann, K.R. and Roka-Moiia, Y. and Montisci, A. and Sheriff, J. and Bluestein, D. and Fiore, G.B. and Pappalardo, F. and Candiani, G. and Redaelli, A. and Slepian, M.J. and Consolo, F.},\r\n year = {2019},\r\n title = {Prothrombotic Activity of Cytokine-Activated Endothelial Cells and Shear-Activated Platelets in the Setting of Ventricular Assist Device Support},\r\n journal = {J Heart Lung Transplant.},\r\n volume = {38},\r\n pages = {658-667},\r\n url_Link ={https://doi.org/10.1007/s11517-019-02012-y},\r\n project = {activation; lvad},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n \n\n \n \n Ngo, A. T. P.; Sheriff, J.; Rocheleau, A. D.; Bucher, M.; Jones, K. R.; Sepp, A. L. I.; Malone, L. E.; Zigomalas, A.; Maloyan, A.; Bahou, W. F.; Bluestein, D.; McCarty, O. J. T.; and Haley, K. M.\n\n\n \n \n \n \n \n Assessment of Neonatal, Cord, and Adult Platelet Granule Trafficking and Secretion.\n \n \n \n \n\n\n \n\n\n\n Platelets, 31: 68-78. 2020.\n \n\n\n\n
\n\n\n\n \n \n \"Assessment link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
\n 
@article{a76,\r\n author = {Ngo, A. T. P. and Sheriff,  J. and Rocheleau, A. D. and Bucher, M. and Jones, K. R. and Sepp, A. L. I. and Malone, L. E. and Zigomalas, A. and Maloyan, A. and Bahou, W. F. and Bluestein, D. and McCarty, O. J. T. and Haley, K. M.},\r\n year = {2020},\r\n title = {Assessment of Neonatal, Cord, and Adult Platelet Granule Trafficking and Secretion},\r\n journal = {Platelets},\r\n volume = {31},\r\n pages = {68-78},\r\n url_Link ={https://www.tandfonline.com/doi/full/10.1080/09537104.2019.1573314},\r\n project = {activation},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n \n\n \n \n Consolo, F.; Sheriff, J.; Gorla, S.; Magri, N.; Bluestein, D.; Pappalardo, F.; Slepian, M. J.; Fiore, G. B.; and Redaelli, A.\n\n\n \n \n \n \n \n High frequency components of hemodynamic shear stress profiles are a major determinant of shear-mediated platelet activation in therapeutic blood recirculating devices.\n \n \n \n \n\n\n \n\n\n\n Sci. Rep., 7: 4994. 2017.\n \n\n\n\n
\n\n\n\n \n \n \"High link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{a21,\r\n author = {Consolo, F. and Sheriff, J. and Gorla, S. and Magri, N. and Bluestein, D. and Pappalardo, F. and Slepian, M. J. and Fiore, G. B. and Redaelli, A.},\r\n year = {2017},\r\n title = {High frequency components of hemodynamic shear stress profiles are a major determinant of shear-mediated platelet activation in therapeutic blood recirculating devices},\r\n journal = {Sci. Rep.},\r\n volume = {7},\r\n pages = {4994},\r\n abstract = {We systematically analyzed the relative contributions of frequency component elements of hemodynamic shear stress waveforms encountered in cardiovascular blood recirculating devices as to overall platelet activation over time. We demonstrated that high frequency oscillations are the major determinants for priming, triggering and yielding activated “prothrombotic behavior” for stimulated platelets, even if the imparted shear stress has low magnitude and brief exposure time. Conversely, the low frequency components of the stress signal, with limited oscillations over time, did not induce significant activation, despite being of high magnitude and/or exposure time. In vitro data were compared with numerical predictions computed according to a recently proposed numerical model of shear-mediated platelet activation. The numerical model effectively resolved the correlation between platelet activation and the various frequency components examined. However, numerical predictions exhibited a different activation trend compared to experimental results for different time points of a stress activation sequence. With this study we provide a more fundamental understanding for the mechanobiological responsiveness of circulating platelets to the hemodynamic environment of cardiovascular devices, and the importance of these environments in mediating life-threatening thromboembolic complications associated with shear-mediated platelet activation. Experimental data will guide further optimization of the thromboresistance of cardiovascular implantable therapeutic devices.},\r\n url_Link ={https://dx.doi.org/10.1038/s41598-017-05130-5},\r\n project = {activation},\r\n type    = {1. Peer-Reviewed Journal Papers},\r\n}\r\n\r\n
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\n We systematically analyzed the relative contributions of frequency component elements of hemodynamic shear stress waveforms encountered in cardiovascular blood recirculating devices as to overall platelet activation over time. We demonstrated that high frequency oscillations are the major determinants for priming, triggering and yielding activated “prothrombotic behavior” for stimulated platelets, even if the imparted shear stress has low magnitude and brief exposure time. Conversely, the low frequency components of the stress signal, with limited oscillations over time, did not induce significant activation, despite being of high magnitude and/or exposure time. In vitro data were compared with numerical predictions computed according to a recently proposed numerical model of shear-mediated platelet activation. The numerical model effectively resolved the correlation between platelet activation and the various frequency components examined. However, numerical predictions exhibited a different activation trend compared to experimental results for different time points of a stress activation sequence. With this study we provide a more fundamental understanding for the mechanobiological responsiveness of circulating platelets to the hemodynamic environment of cardiovascular devices, and the importance of these environments in mediating life-threatening thromboembolic complications associated with shear-mediated platelet activation. Experimental data will guide further optimization of the thromboresistance of cardiovascular implantable therapeutic devices.\n
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\n \n\n \n \n Slepian, M. J.; Sheriff, J.; Hutchinson, M.; Tran, P.; Bajaj, N.; Garcia, J. G. N.; Saavedra, S. S.; and Bluestein, D.\n\n\n \n \n \n \n \n Shear-Mediated Platelet Activation in the Free Flow: Perspectives on the Emerging Spectrum of Cell Mechanobiological Mechanisms Mediating Cardiovascular Implant Thrombosis.\n \n \n \n \n\n\n \n\n\n\n J. Biomech, 50: 20–25. 2017.\n \n\n\n\n
\n\n\n\n \n \n \"Shear-Mediated link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{a10,\r\n author = {Slepian, M. J. and Sheriff, J. and Hutchinson, M. and Tran, P. and Bajaj, N. and Garcia, J. G. N. and Saavedra, S. S. and Bluestein, D.},\r\n year = {2017},\r\n title = {Shear-Mediated Platelet Activation in the Free Flow:  Perspectives on the Emerging Spectrum of Cell Mechanobiological Mechanisms Mediating Cardiovascular Implant Thrombosis},\r\n journal = {J. Biomech},\r\n volume = {50},\r\n pages = {20–25},\r\n abstract = {Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.},\r\n project = {activation and lvad},\r\n url_Link = {https://dx.doi.org/10.1016/j.jbiomech.2016.11.016},\r\n type = {1. Peer-Reviewed Journal Papers}\r\n}\r\n\r\n
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\n Shear-mediated platelet activation (SMPA) is central in thrombosis of implantable cardiovascular therapeutic devices. Despite the morbidity and mortality associated with thrombosis of these devices, our understanding of mechanisms operative in SMPA, particularly in free flowing blood, remains limited. Herein we present and discuss a range of emerging mechanisms for consideration for “free flow” activation under supraphysiologic shear. Further definition and manipulation of these mechanisms will afford opportunities for novel pharmacologic and mechanical strategies to limit SMPA and enhance overall implant device safety.\n
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\n \n\n \n \n Sheriff, J.; Tran, P. L.; Hutchinson, M.; DeCook, T.; Slepian, M. J.; Bluestein, D.; and Jesty, J.\n\n\n \n \n \n \n \n Repetitive Hypershear Activates and Sensitizes Platelets in a Dose-Dependent Manner.\n \n \n \n \n\n\n \n\n\n\n Artif. Organs, 40: 586-595. 2016.\n \n\n\n\n
\n\n\n\n \n \n \"Repetitive link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{z6,\r\n author = {Sheriff, J. and Tran, P. L. and Hutchinson, M. and DeCook, T. and Slepian, M. J. and Bluestein, D. and Jesty, J.},\r\n year = {2016},\r\n title = {Repetitive Hypershear Activates and Sensitizes Platelets in a Dose-Dependent Manner},\r\n journal = {Artif. Organs},\r\n volume = {40},\r\n issue = {6},\r\n pages = {586-595},\r\n url_Link = {https://doi.org/10.1111/aor.12602},\r\n abstract = {Implantation of mechanical circulatory support (MCS) devices-ventricular assist devices and the total artificial heart-has emerged as a vital therapy for advanced and end-stage heart failure. Unfortunately, MCS patients face the requirement of life-long antiplatelet and anticoagulant therapy to combat thrombotic complications resulting from the dynamic and supraphysiologic shear stress conditions associated with such devices, whose effect on platelet activation is poorly understood. We developed a syringe-capillary viscometer-the "platelet hammer"-that repeatedly exposed platelets to average shear stresses up to 1000 dyne/cm(2) for as short as 25 ms. Platelet activation state was measured using a modified prothrombinase assay, with morphological changes analyzed using scanning electron microscopy. We observed an increase in platelet activation state and post-high shear platelet activation rate, or sensitization, with an increase in stress accumulation (SA), the product of shear stress and exposure time. A significant increase in platelet activation state was observed beyond an SA of 1500 dyne-s/cm(2) , with a marked increase in pseudopod length visible beyond an SA of 1000 dyne-s/cm(2) . Utility of the platelet hammer extends to studies of other shear-dependent pathologies, and may assist development of approaches to enhance the safety and effectiveness of MCS devices and objective antithrombotic pharmacotherapy management.},\r\n project = {activation},\r\n type = {1. Peer-Reviewed Journal Papers}\r\n}\r\n\r\n
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\n Implantation of mechanical circulatory support (MCS) devices-ventricular assist devices and the total artificial heart-has emerged as a vital therapy for advanced and end-stage heart failure. Unfortunately, MCS patients face the requirement of life-long antiplatelet and anticoagulant therapy to combat thrombotic complications resulting from the dynamic and supraphysiologic shear stress conditions associated with such devices, whose effect on platelet activation is poorly understood. We developed a syringe-capillary viscometer-the \"platelet hammer\"-that repeatedly exposed platelets to average shear stresses up to 1000 dyne/cm(2) for as short as 25 ms. Platelet activation state was measured using a modified prothrombinase assay, with morphological changes analyzed using scanning electron microscopy. We observed an increase in platelet activation state and post-high shear platelet activation rate, or sensitization, with an increase in stress accumulation (SA), the product of shear stress and exposure time. A significant increase in platelet activation state was observed beyond an SA of 1500 dyne-s/cm(2) , with a marked increase in pseudopod length visible beyond an SA of 1000 dyne-s/cm(2) . Utility of the platelet hammer extends to studies of other shear-dependent pathologies, and may assist development of approaches to enhance the safety and effectiveness of MCS devices and objective antithrombotic pharmacotherapy management.\n
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\n \n\n \n \n Marom, G.; and Bluestein, D.\n\n\n \n \n \n \n \n Lagrangian Methods for Blood Damage Estimation in Cardiovascular Devices - How Numerical Implementation Affects the Results.\n \n \n \n \n\n\n \n\n\n\n Expert Rev. Med. Devices, 13: 113-122. 2015.\n \n\n\n\n
\n\n\n\n \n \n \"Lagrangian link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{z8,\r\n author = {Marom, G. and Bluestein, D.},\r\n year = {2015},\r\n title = {Lagrangian Methods for Blood Damage Estimation in Cardiovascular Devices - How Numerical Implementation Affects the Results},\r\n journal = {Expert Rev. Med. Devices},\r\n volume = {13},\r\n issue = {2},\r\n pages = {113-122},\r\n url_Link = {https://doi.org/10.1586/17434440.2016.1133283},\r\n abstract = {This paper evaluated the influence of various numerical implementation assumptions on predicting blood damage in cardiovascular devices using Lagrangian methods with Eulerian computational fluid dynamics. The implementation assumptions that were tested included various seeding patterns, stochastic walk model, and simplified trajectory calculations with pathlines. Post processing implementation options that were evaluated included single passage and repeated passages stress accumulation and time averaging. This study demonstrated that the implementation assumptions can significantly affect the resulting stress accumulation, i.e., the blood damage model predictions. Careful considerations should be taken in the use of Lagrangian models. Ultimately, the appropriate assumptions should be considered based the physics of the specific case and sensitivity analysis, similar to the ones presented here, should be employed.},\r\n project = {activation},\r\n type = {1. Peer-Reviewed Journal Papers}\r\n}\r\n\r\n
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\n This paper evaluated the influence of various numerical implementation assumptions on predicting blood damage in cardiovascular devices using Lagrangian methods with Eulerian computational fluid dynamics. The implementation assumptions that were tested included various seeding patterns, stochastic walk model, and simplified trajectory calculations with pathlines. Post processing implementation options that were evaluated included single passage and repeated passages stress accumulation and time averaging. This study demonstrated that the implementation assumptions can significantly affect the resulting stress accumulation, i.e., the blood damage model predictions. Careful considerations should be taken in the use of Lagrangian models. Ultimately, the appropriate assumptions should be considered based the physics of the specific case and sensitivity analysis, similar to the ones presented here, should be employed.\n
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\n \n\n \n \n Soares, J. S.; Sheriff, J.; and Bluestein, D.\n\n\n \n \n \n \n \n A novel mathematical model of activation and sensitization of platelets subjected to dynamic stress histories.\n \n \n \n \n\n\n \n\n\n\n Biomech. Model. Mechan, 12: 1127-1141. 2013.\n \n\n\n\n
\n\n\n\n \n \n \"A paper\n  \n \n \n \"A link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{z27,\r\n author = {Soares, J. S. and Sheriff, J. and Bluestein, D.},\r\n year = {2013},\r\n title = {A novel mathematical model of activation and sensitization of platelets subjected to dynamic stress histories},\r\n journal = {Biomech. Model. Mechan},\r\n volume = {12},\r\n issue = {6},\r\n pages = {1127-1141},\r\n url_Paper={/labs/dbluestein/PDF/Soares_2013_platelet_activation_model.pdf},\r\n url_Link = {https://doi.org/10.1007/s10237-013-0469-0},\r\n abstract = {Blood recirculating devices, such as ventricular assist devices and prosthetic heart valves, are burdened by thromboembolic complications requiring complex and lifelong anticoagulant therapy with its inherent hemorrhagic risks. Pathologic flow patterns occurring in such devices chronically activate platelets, and the optimization of their thrombogenic performance requires the development of flow-induced platelet activation models. However, existing models are based on empirical correlations using the well-established power law paradigm of constant levels of shear stress during certain exposure times as factors for mechanical platelet activation. These models are limited by their range of application and do not account for other relevant phenomena, such as loading rate dependence and platelet sensitization to high stress conditions, which characterize the dynamic flow conditions in devices. These limitations were addressed by developing a new class of phenomenological stress-induced platelet activation models that specifies the rate of platelet activation as a function of the entire stress history and results in a differential equation that can be directly integrated to calculate the cumulative levels of activation. The proposed model reverts to the power law under constant shear stress conditions and is able to describe experimental results in response to a diverse range of highly dynamic stress conditions found in blood recirculating devices. The model was tested in vitro under emulated device flow conditions and correlates well with experimental results. This new model provides a reliable and robust mathematical tool that can be incorporated into computational fluid dynamic studies in order to optimize design, with the goal of improving the thrombogenic performance of blood recirculating devices.},\r\n project = {activation},\r\n type = {1. Peer-Reviewed Journal Papers}\r\n}\r\n\r\n
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\n Blood recirculating devices, such as ventricular assist devices and prosthetic heart valves, are burdened by thromboembolic complications requiring complex and lifelong anticoagulant therapy with its inherent hemorrhagic risks. Pathologic flow patterns occurring in such devices chronically activate platelets, and the optimization of their thrombogenic performance requires the development of flow-induced platelet activation models. However, existing models are based on empirical correlations using the well-established power law paradigm of constant levels of shear stress during certain exposure times as factors for mechanical platelet activation. These models are limited by their range of application and do not account for other relevant phenomena, such as loading rate dependence and platelet sensitization to high stress conditions, which characterize the dynamic flow conditions in devices. These limitations were addressed by developing a new class of phenomenological stress-induced platelet activation models that specifies the rate of platelet activation as a function of the entire stress history and results in a differential equation that can be directly integrated to calculate the cumulative levels of activation. The proposed model reverts to the power law under constant shear stress conditions and is able to describe experimental results in response to a diverse range of highly dynamic stress conditions found in blood recirculating devices. The model was tested in vitro under emulated device flow conditions and correlates well with experimental results. This new model provides a reliable and robust mathematical tool that can be incorporated into computational fluid dynamic studies in order to optimize design, with the goal of improving the thrombogenic performance of blood recirculating devices.\n
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\n \n\n \n \n Sheriff, J.; Soares, J. S.; Xenos, M.; Jesty, J.; Slepian, M. J.; and Bluestein, D.\n\n\n \n \n \n \n \n Evaluation of shear-induced platelet activation models under constant and dynamic shear stress loading conditions relevant to devices.\n \n \n \n \n\n\n \n\n\n\n Ann. Biomed. Eng, 41: 1279-1296. Erratum in: 41(12):2712. 2013.\n \n\n\n\n
\n\n\n\n \n \n \"Evaluation paper\n  \n \n \n \"Evaluation link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n  \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{z31,\r\n author = {Sheriff, J. and Soares, J. S. and Xenos, M. and Jesty, J. and Slepian, M. J. and Bluestein, D.},\r\n year = {2013},\r\n title = {Evaluation of shear-induced platelet activation models under constant and dynamic shear stress loading conditions relevant to devices},\r\n journal = { Ann. Biomed. Eng},\r\n volume = {41},\r\n issue = {6},\r\n pages = {1279-1296. Erratum in: 41(12):2712},\r\n url_Paper={/labs/dbluestein/PDF/Sheriff_2013_platelet_activation_models.pdf},\r\n url_Link = {https://doi.org/10.1007/s10439-013-0758-x},\r\n abstract = {The advent of implantable blood-recirculating devices such as left ventricular assist devices and prosthetic heart valves provides a viable therapy for patients with end-stage heart failure and valvular disease. However, device-generated pathological flow patterns result in thromboembolic complications that require complex and lifelong anticoagulant therapy, which entails hemorrhagic risks and is not appropriate for certain patients. Optimizing the thrombogenic performance of such devices utilizing numerical simulations requires the development of predictive platelet activation models that account for variations in shear-loading rates characterizing blood flow through such devices. Platelets were exposed in vitro to both dynamic and constant shear stress conditions emulating those found in blood-recirculating devices in order to determine their shear-induced activation and sensitization response. Both these behaviors were found to be dependent on the shear loading rates, in addition to shear stress magnitude and exposure time. We then critically examined several current models and evaluated their predictive capabilities using these results. Shear loading rate terms were then included to account for dynamic aspects that are either ignored or partially considered by these models, and model parameters were optimized. Independent optimization for each of the two types of shear stress exposure conditions tested resulted in different sets of best-fit constants, indicating that universal optimization may not be possible. Inherent limitations of the current models require a paradigm shift from these integral-based discretized power law models to better address the dynamic conditions encountered in blood-recirculating devices.},\r\n project = {activation},\r\n type = {1. Peer-Reviewed Journal Papers}\r\n}\r\n\r\n
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\n The advent of implantable blood-recirculating devices such as left ventricular assist devices and prosthetic heart valves provides a viable therapy for patients with end-stage heart failure and valvular disease. However, device-generated pathological flow patterns result in thromboembolic complications that require complex and lifelong anticoagulant therapy, which entails hemorrhagic risks and is not appropriate for certain patients. Optimizing the thrombogenic performance of such devices utilizing numerical simulations requires the development of predictive platelet activation models that account for variations in shear-loading rates characterizing blood flow through such devices. Platelets were exposed in vitro to both dynamic and constant shear stress conditions emulating those found in blood-recirculating devices in order to determine their shear-induced activation and sensitization response. Both these behaviors were found to be dependent on the shear loading rates, in addition to shear stress magnitude and exposure time. We then critically examined several current models and evaluated their predictive capabilities using these results. Shear loading rate terms were then included to account for dynamic aspects that are either ignored or partially considered by these models, and model parameters were optimized. Independent optimization for each of the two types of shear stress exposure conditions tested resulted in different sets of best-fit constants, indicating that universal optimization may not be possible. Inherent limitations of the current models require a paradigm shift from these integral-based discretized power law models to better address the dynamic conditions encountered in blood-recirculating devices.\n
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\n \n\n \n \n Sheriff, J.; Bluestein, D.; Girdhar, G.; and Jesty, J.\n\n\n \n \n \n \n \n High-Shear Stress Sensitizes Platelets to Subsequent Low-Shear Conditions.\n \n \n \n \n\n\n \n\n\n\n Ann Biomed Eng, 38: 1442-1450. 2010.\n \n\n\n\n
\n\n\n\n \n \n \"High-Shear paper\n  \n \n \n \"High-Shear link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
\n 
@article{z45,\r\n author = {Sheriff, J. and Bluestein, D. and Girdhar, G. and Jesty, J.},\r\n year = {2010},\r\n title = {High-Shear Stress Sensitizes Platelets to Subsequent Low-Shear Conditions},\r\n journal = {Ann Biomed Eng},\r\n volume = {38},\r\n issue = {4},\r\n pages = {1442-1450},\r\n url_Paper={/labs/dbluestein/PDF/Sheriff_2010_platelet_sensitization.pdf},\r\n url_Link = {https://doi.org/10.1007/s10439-010-9936-2},\r\n abstract = {Individuals with mechanical heart valve implants are plagued by flow-induced thromboembolic complications, which are undoubtedly caused by platelet activation. Flow fields in or around the affected regions involve brief exposure to pathologically high-shear stresses on the order of 100 to 1000 dyne/cm(2). Although high shear is known to activate platelets directly, their subsequent behavior is not known. We hypothesize that the post-high-shear activation behavior of platelets is particularly relevant in understanding the increased thrombotic risk associated with blood-recirculating prosthetic cardiovascular devices. Purified platelets were exposed to brief (5-40 s) periods of high-shear stress, and then exposed to longer periods (15-60 min) of low shear. Their activation state was measured using a prothrombinase-based assay. Platelets briefly exposed to an initial high-shear stress (e.g., 60 dyne/cm(2) for 40 s) activate a little, but this study shows that they are now sensitized, and when exposed to subsequent low shear stress, they activate at least 20-fold faster than platelets not initially exposed to high shear. The results show that platelets in vitro exposed beyond a threshold of high-shear stress are primed for subsequent activation under normal cardiovascular circulation conditions, and they do not recover from the initial high-shear insult.},\r\n project = {activation},\r\n type = {1. Peer-Reviewed Journal Papers}\r\n}\r\n\r\n
\n
\n\n\n
\n Individuals with mechanical heart valve implants are plagued by flow-induced thromboembolic complications, which are undoubtedly caused by platelet activation. Flow fields in or around the affected regions involve brief exposure to pathologically high-shear stresses on the order of 100 to 1000 dyne/cm(2). Although high shear is known to activate platelets directly, their subsequent behavior is not known. We hypothesize that the post-high-shear activation behavior of platelets is particularly relevant in understanding the increased thrombotic risk associated with blood-recirculating prosthetic cardiovascular devices. Purified platelets were exposed to brief (5-40 s) periods of high-shear stress, and then exposed to longer periods (15-60 min) of low shear. Their activation state was measured using a prothrombinase-based assay. Platelets briefly exposed to an initial high-shear stress (e.g., 60 dyne/cm(2) for 40 s) activate a little, but this study shows that they are now sensitized, and when exposed to subsequent low shear stress, they activate at least 20-fold faster than platelets not initially exposed to high shear. The results show that platelets in vitro exposed beyond a threshold of high-shear stress are primed for subsequent activation under normal cardiovascular circulation conditions, and they do not recover from the initial high-shear insult.\n
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\n \n\n \n \n Girdhar, G.; and Bluestein, D.\n\n\n \n \n \n \n \n Biological effects of dynamic shear stress in cardiovascular pathologies and devices.\n \n \n \n \n\n\n \n\n\n\n Expert Rev Med Devices, 5: 167-181. 2008.\n \n\n\n\n
\n\n\n\n \n \n \"Biological paper\n  \n \n \n \"Biological link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
\n 
@article{z56,\r\n author = {Girdhar, G. and Bluestein, D.},\r\n year = {2008},\r\n title = {Biological effects of dynamic shear stress in cardiovascular pathologies and devices},\r\n journal = {Expert Rev Med Devices},\r\n volume = {5},\r\n issue = {2},\r\n pages = {167-181},\r\n url_Paper={/labs/dbluestein/PDF/Girdhar_2008_shear_stress_pathologies_devices.pdf},\r\n url_Link = {https://doi.org/10.1586/17434440.5.2.167},\r\n abstract = {Altered and highly dynamic shear stress conditions have been implicated in endothelial dysfunction leading to cardiovascular disease, and in thromboembolic complications in prosthetic cardiovascular devices. In addition to vascular damage, the pathological flow patterns characterizing cardiovascular pathologies and blood flow in prosthetic devices induce shear activation and damage to blood constituents. Investigation of the specific and accentuated effects of such flow-induced perturbations on individual cell-types in vitro is critical for the optimization of device design, whereby specific design modifications can be made to minimize such perturbations. Such effects are also critical in understanding the development of cardiovascular disease. This review addresses limitations to replicate such dynamic flow conditions in vitro and also introduces the idea of modified in vitro devices, one of which is developed in the authors' laboratory, with dynamic capabilities to investigate the aforementioned effects in greater detail.},\r\n project = {activation},\r\n type = {1. Peer-Reviewed Journal Papers}\r\n}\r\n\r\n
\n
\n\n\n
\n Altered and highly dynamic shear stress conditions have been implicated in endothelial dysfunction leading to cardiovascular disease, and in thromboembolic complications in prosthetic cardiovascular devices. In addition to vascular damage, the pathological flow patterns characterizing cardiovascular pathologies and blood flow in prosthetic devices induce shear activation and damage to blood constituents. Investigation of the specific and accentuated effects of such flow-induced perturbations on individual cell-types in vitro is critical for the optimization of device design, whereby specific design modifications can be made to minimize such perturbations. Such effects are also critical in understanding the development of cardiovascular disease. This review addresses limitations to replicate such dynamic flow conditions in vitro and also introduces the idea of modified in vitro devices, one of which is developed in the authors' laboratory, with dynamic capabilities to investigate the aforementioned effects in greater detail.\n
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\n \n\n \n \n Nobili, M.; Sheriff, J.; Morbiducci, U.; Redaelli, A.; and Bluestein, D.\n\n\n \n \n \n \n \n Platelet activation due to hemodynamic shear stresses: Damage accumulation model and comparison to in vitro measurements.\n \n \n \n \n\n\n \n\n\n\n ASAIO J, 54: 64-72. 2008.\n \n\n\n\n
\n\n\n\n \n \n \"Platelet paper\n  \n \n \n \"Platelet link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n  \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{z58,\r\n author = {Nobili, M. and Sheriff, J. and Morbiducci, U. and Redaelli, A. and Bluestein, D.},\r\n year = {2008},\r\n title = {Platelet activation due to hemodynamic shear stresses: Damage accumulation model and comparison to in vitro measurements},\r\n journal = {ASAIO J},\r\n volume = { 54},\r\n issue = {1},\r\n pages = {64-72},\r\n url_Paper={/labs/dbluestein/PDF/Nobili_2008_platelet_damage_accumulation_model.pdf},\r\n url_Link = {https://doi.org/10.1097/MAT.0b013e31815d6898},\r\n abstract = {The need to optimize the thrombogenic performance of blood recirculating cardiovascular devices, e.g., prosthetic heart valves (PHV) and ventricular assist devices (VAD), is accentuated by the fact that most of them require lifelong anticoagulation therapy that does not eliminate the risk of thromboembolic complications. The formation of thromboemboli in the flow field of these devices is potentiated by contact with foreign surfaces and regional flow phenomena that stimulate blood clotting, especially platelets. With the lack of appropriate methodology, device manufacturers do not specifically optimize for thrombogenic performance. Such optimization can be facilitated by formulating a robust numerical methodology with predictive capabilities of flow-induced platelet activation. In this study, a phenomenological model for platelet cumulative damage, identified by means of genetic algorithms (GAs), was correlated with in vitro experiments conducted in a Hemodynamic Shearing Device (HSD). Platelets were uniformly exposed to flow shear representing the lower end of the stress levels encountered in devices, and platelet activity state (PAS) was measured in response to six dynamic shear stress waveforms representing repeated passages through a device, and correlated to the predictions of the damage accumulation model. Experimental results demonstrated an increase in PAS with a decrease in "relaxation" time between pulses. The model predictions were in very good agreement with the experimental results.},\r\n project = {activation},\r\n type = {1. Peer-Reviewed Journal Papers}\r\n}\r\n\r\n
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\n The need to optimize the thrombogenic performance of blood recirculating cardiovascular devices, e.g., prosthetic heart valves (PHV) and ventricular assist devices (VAD), is accentuated by the fact that most of them require lifelong anticoagulation therapy that does not eliminate the risk of thromboembolic complications. The formation of thromboemboli in the flow field of these devices is potentiated by contact with foreign surfaces and regional flow phenomena that stimulate blood clotting, especially platelets. With the lack of appropriate methodology, device manufacturers do not specifically optimize for thrombogenic performance. Such optimization can be facilitated by formulating a robust numerical methodology with predictive capabilities of flow-induced platelet activation. In this study, a phenomenological model for platelet cumulative damage, identified by means of genetic algorithms (GAs), was correlated with in vitro experiments conducted in a Hemodynamic Shearing Device (HSD). Platelets were uniformly exposed to flow shear representing the lower end of the stress levels encountered in devices, and platelet activity state (PAS) was measured in response to six dynamic shear stress waveforms representing repeated passages through a device, and correlated to the predictions of the damage accumulation model. Experimental results demonstrated an increase in PAS with a decrease in \"relaxation\" time between pulses. The model predictions were in very good agreement with the experimental results.\n
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\n  \n 5. Refereed Conference Proceedings\n \n \n (1)\n \n \n
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\n \n\n \n \n Gao, C.; Zhang, P.; and Bluestein, D.\n\n\n \n \n \n \n \n Multiscale Modeling of Mechanotransduction Processes in Flow-Induced Platelet Activation.\n \n \n \n \n\n\n \n\n\n\n In Proceedings of the 2nd IEEE International Conference on High Performance and Smart Computing (HPSC 2016), pages 274-279, New York, NY, April 9-10 2016. \n \n\n\n\n
\n\n\n\n \n \n \"Multiscale link\n  \n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@inproceedings{a20,\r\n author = {Gao, C. and Zhang, P. and Bluestein, D.}, \r\n year = {2016}, \r\n title = {Multiscale Modeling of Mechanotransduction Processes in Flow-Induced Platelet Activation}, \r\n booktitle = {Proceedings of the 2nd IEEE International Conference on High Performance and Smart Computing (HPSC 2016)}, \r\n address = {New York, NY}, \r\n month = {April 9-10}, \r\n url_Link = {https://dx.doi.org/10.1109/BigDataSecurity-HPSC-IDS.2016.13 }, \r\n pages = {274-279}, \r\n project = {activation},\r\n type = {5. Refereed Conference Proceedings}\r\n}\r\n\r\n
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\n  \n 6. Abstracts\n \n \n (43)\n \n \n
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\n \n\n \n \n Palomares, D. E.; Deymier, P.; Momayez, M.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Snore Vibro-acoustic Platelet Activation: A Thrombotic Risk Factor in Obstructive Sleep Apnea.\n \n \n \n\n\n \n\n\n\n In 68th Annual Conference of the American Society of Artificial Internal Organs (ASAIO), San Francisco, CA, June 14-17 2023. \n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@inproceedings{a194,\r\n author = {Palomares, D. E. and Deymier, P. and Momayez, M. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2023},\r\n title = {Snore Vibro-acoustic Platelet Activation: A Thrombotic Risk Factor in Obstructive Sleep Apnea},\r\n booktitle = {68th Annual Conference of the American Society of Artificial Internal Organs (ASAIO)},\r\n address = {San Francisco, CA},\r\n month = {June 14-17},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Han, C.; Zhu, Y.; Zhang, P.; Sheriff, J.; Slepian, M.; Bluestein, D.; and Deng, Y.\n\n\n \n \n \n \n AI-Guided Multiscale Modeling for Platelets Aggregation and Adhesion under Shear Flow.\n \n \n \n\n\n \n\n\n\n In 2021 Biomedical Engineering Society (BMES) Annual Meeting, Orlando, FL, October 6-9 2021. \n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@inproceedings{a156,\r\n author = {Han, C. and Zhu, Y. and Zhang, P. and Sheriff, J. and Slepian, M.J. and Bluestein, D. and Deng, Y.},\r\n year = {2021},\r\n title = {AI-Guided Multiscale Modeling for Platelets Aggregation and Adhesion under Shear Flow},\r\n booktitle = {2021 Biomedical Engineering Society (BMES) Annual Meeting},\r\n address = {Orlando, FL},\r\n month = {October 6-9},\r\n project = {activation, adhesion, ML, multiscale},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Wang, P.; Zhang, P.; Zhang, Z.; Bahou, W.; Deng, Y.; and Bluestein, D.\n\n\n \n \n \n \n Machine Learning-guided Analysis of Adult and Cord Platelet Adhesion Dynamics.\n \n \n \n\n\n \n\n\n\n In International Society on Thrombosis and Haemostasis (ISTH) Congress 2021, Philadelphia, PA - Virtual, July 17-21 2021. \n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@inproceedings{a150,\r\n author = {Sheriff, J. and Wang, P. and Zhang, P. and Zhang, Z. and Bahou, W. and Deng, Y. and Bluestein, D.},\r\n year = {2021},\r\n title = {Machine Learning-guided Analysis of Adult and Cord Platelet Adhesion Dynamics},\r\n booktitle = {International Society on Thrombosis and Haemostasis (ISTH) Congress 2021},\r\n address = {Philadelphia, PA - Virtual},\r\n month = {July 17-21},\r\n project = {activation, adhesion, ML},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Wang, P.; Zhang, P.; Zhang, Z.; Bahou, W.; Deng, Y.; and Bluestein, D.\n\n\n \n \n \n \n Platelet Adhesion Dynamics: Machine Learning-Assisted Analysis of Adult and Cord Platelets and Development of A Multiscale Model.\n \n \n \n\n\n \n\n\n\n In Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), Virtual, June 14-18 2021. \n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@inproceedings{a146,\r\n author = {Sheriff, J. and Wang, P. and Zhang, P. and Zhang, Z. and Bahou, W. and Deng, Y. and Bluestein, D.},\r\n year = {2021},\r\n title = {Platelet Adhesion Dynamics: Machine Learning-Assisted Analysis of Adult and Cord Platelets and Development of A Multiscale Model},\r\n booktitle = {Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C)},\r\n address = {Virtual},\r\n month = {June 14-18},\r\n project = {activation, multiscale},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Miller-Gutierrez, S.; Roka-Moiia, Y.; Avalani, K.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Platelet Microparticles Paradoxically Promote Thrombin Generation While Inhibiting Platelet Aggregation.\n \n \n \n\n\n \n\n\n\n In ASAIO 2021 66th Annual Conference, Washington, D.C., June 10-12 2021. \n \n\n\n\n
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@inproceedings{a145,\r\n author = {Miller-Gutierrez, S. and Roka-Moiia, Y. and Avalani, K. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2021},\r\n title = {Platelet Microparticles Paradoxically Promote Thrombin Generation While Inhibiting Platelet Aggregation},\r\n booktitle = {ASAIO 2021 66th Annual Conference},\r\n address = {Washington, D.C.},\r\n month = {June 10-12},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Miller-Gutierrez, S.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n To Bleed or Not to Bleed: MCS-Related Shear Stress Promotes Redistribution of GPIb and αIIbβ3 from Platelets to Microparticles Thus Impairing Platelet Hemostatic Function.\n \n \n \n\n\n \n\n\n\n In ISHLT 2021 - 41st Annual Meeting & Scientific Sessions, Virtual, April 24-28 2021. \n \n\n\n\n
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@inproceedings{a143,\r\n author = {Roka-Moiia, Y. and Miller-Gutierrez, S. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2021},\r\n title = {To Bleed or Not to Bleed: MCS-Related Shear Stress Promotes Redistribution of GPIb and αIIbβ3 from Platelets to Microparticles Thus Impairing Platelet Hemostatic Function},\r\n booktitle = {ISHLT 2021 - 41st Annual Meeting & Scientific Sessions},\r\n address = {Virtual},\r\n month = {April 24-28},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Palomares, D. E.; Jason, L.; Tran, P. L.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n VAD Derived Mechano-Acoustics Lead to Platelet Activation.\n \n \n \n\n\n \n\n\n\n In Virtual ASAIO Conference, Virtual, June 2020. \n \n\n\n\n
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@inproceedings{a125,\r\n author = {Palomares, D. E. and Jason, L. and Tran, P. L. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2020},\r\n title = {VAD Derived Mechano-Acoustics Lead to Platelet Activation},\r\n booktitle = {Virtual ASAIO Conference},\r\n address = {Virtual},\r\n month = {June},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Miller-Gutierrez, S.; Sweedo, A.; Roka-Moiia, Y.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Platelet Membrane Fluidization via Exogenous Cholesterol Modulates Shear-Mediated Platelet Activation.\n \n \n \n\n\n \n\n\n\n In Virtual ASAIO Conference, Virtual, June 2020. \n \n\n\n\n
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@inproceedings{a124,\r\n author = {Miller-Gutierrez, S. and Sweedo, A. and Roka-Moiia, Y. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2020},\r\n title = {Platelet Membrane Fluidization via Exogenous Cholesterol Modulates Shear-Mediated Platelet Activation},\r\n booktitle = {Virtual ASAIO Conference},\r\n address = {Virtual},\r\n month = {June},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Lewis, S.; Sheriff, J.; Italiano, J. E.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Membrane Scrambling Induced by MCS-Related Shear Stress is not Associated with Platelet Apoptosis.\n \n \n \n\n\n \n\n\n\n In Virtual ASAIO Conference, Virtual, June 2020. \n \n\n\n\n
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@inproceedings{a123,\r\n author = {Roka-Moiia, Y. and Lewis, S. and Sheriff, J. and Italiano, J. E. and Bluestein, D. and Slepian, M. J.},\r\n year = {2020},\r\n title = {Membrane Scrambling Induced by MCS-Related Shear Stress is not Associated with Platelet Apoptosis},\r\n booktitle = {Virtual ASAIO Conference},\r\n address = {Virtual},\r\n month = {June},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sweedo, A.; Niemiec, M.; Breshears, L.; Sheriff, J.; Bluestein, D.; Slepian, M. J.; and Teran Arce, F.\n\n\n \n \n \n \n Repetitive Mechanostimulation of Platelets Alters Regional Membrane Stiffness and its Distribution.\n \n \n \n\n\n \n\n\n\n In Virtual ASAIO Conference, Virtual, June 2020. \n \n\n\n\n
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@inproceedings{a122,\r\n author = {Sweedo, A. and Niemiec, M. and Breshears, L. and Sheriff, J. and Bluestein, D. and Slepian, M. J. and Teran Arce, F.},\r\n year = {2020},\r\n title = {Repetitive Mechanostimulation of Platelets Alters Regional Membrane Stiffness and its Distribution},\r\n booktitle = {Virtual ASAIO Conference},\r\n address = {Virtual},\r\n month = {June},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Miller-Gutierrez, S.; Sweedo, A.; Roka-Moiia, Y.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Modulation of Membrane Cholesterol Content Decreases Shear-Mediated Platelet Activation and Aggregation.\n \n \n \n\n\n \n\n\n\n In Virtual ASAIO Conference, Virtual, June 2020. \n \n\n\n\n
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@inproceedings{a121,\r\n author = {Miller-Gutierrez, S. and Sweedo, A. and Roka-Moiia, Y. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2020},\r\n title = {Modulation of Membrane Cholesterol Content Decreases Shear-Mediated Platelet Activation and Aggregation},\r\n booktitle = {Virtual ASAIO Conference},\r\n address = {Virtual},\r\n month = {June},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Lewis, S.; Sheriff, J.; Italiano, J. E.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n MCS Shear Stress Exposure Induces Platelet Mitochondrial Membrane Depolarization and Scrambling Without Inducing Apoptosis.\n \n \n \n\n\n \n\n\n\n In Virtual ASAIO Conference, Virtual, June 2020. \n \n\n\n\n
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@inproceedings{a120,\r\n author = {Roka-Moiia, Y. and Lewis, S. and Sheriff, J. and Italiano, J. E. and Bluestein, D. and Slepian, M. J.},\r\n year = {2020},\r\n title = {MCS Shear Stress Exposure Induces Platelet Mitochondrial Membrane Depolarization and Scrambling Without Inducing Apoptosis},\r\n booktitle = {Virtual ASAIO Conference},\r\n address = {Virtual},\r\n month = {June},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Palomares, D. E.; Jensen, L.; Le, P.; Ammann, K.; Liu, Y.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Mechano-Acoustic Mediated Platelet Activation in Ventricular Assist Devices.\n \n \n \n\n\n \n\n\n\n In Virtual ASAIO Conference, Virtual, June 2020. \n \n\n\n\n
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@inproceedings{a119,\r\n author = {Palomares, D. E. and Jensen, L. and Le, P. and Ammann, K. and Liu, Y. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2020},\r\n title = {Mechano-Acoustic Mediated Platelet Activation in Ventricular Assist Devices},\r\n booktitle = {Virtual ASAIO Conference},\r\n address = {Virtual},\r\n month = {June},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Palomares, D. E.; Jensen, L.; Le, P.; Ammann, K.; Liu, Y.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Mechano-Acoustic Mediated Platelet Activation in Ventricular Assist Devices.\n \n \n \n\n\n \n\n\n\n In Virtual ASAIO Conference, Virtual, June 2020. \n \n\n\n\n
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@inproceedings{a118,\r\n author = {Palomares, D. E. and Jensen, L. and Le, P. and Ammann, K. and Liu, Y. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2020},\r\n title = {Mechano-Acoustic Mediated Platelet Activation in Ventricular Assist Devices},\r\n booktitle = {Virtual ASAIO Conference},\r\n address = {Virtual},\r\n month = {June},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Zhang, P.; Zhang, Z.; Wang, P.; Deng, Y.; and Bluestein, D.\n\n\n \n \n \n \n Characterization of Flow-Mediated Platelet Activation and Adhesion Dynamics via Semi-Unsupervised Learning.\n \n \n \n\n\n \n\n\n\n In Virtual Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), Vail, Colorado, June 17-20 2020. \n \n\n\n\n
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@inproceedings{a115,\r\n author = {Sheriff, J. and Zhang, P. and Zhang, Z. and Wang, P. and Deng, Y. and Bluestein, D.},\r\n year = {2020},\r\n title = {Characterization of Flow-Mediated Platelet Activation and Adhesion Dynamics via Semi-Unsupervised Learning},\r\n booktitle = {Virtual Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C)},\r\n address = {Vail, Colorado},\r\n month = {June 17-20},\r\n project = {activation; machine learning; multiscale},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Italiano, J.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n Yin and Yang of MCS-Related Coagulopathy: Shear Stress Promotes Platelet Prothrombosis and Microparticle Generation While Inducing Integrin Downregulation and Decreased Aggregability.\n \n \n \n\n\n \n\n\n\n In International Society for Heart and Lung Transplantation (ISHLT) 2020 Annual Meeting (Canceled), Montreal, Canada, April 22-25 2020. \n \n\n\n\n
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@inproceedings{a112,\r\n author = {Roka-Moiia, Y. and Italiano, J. and Sheriff, J. and Bluestein, D. and Slepian, M.J.},\r\n year = {2020},\r\n title = {Yin and Yang of MCS-Related Coagulopathy: Shear Stress Promotes Platelet Prothrombosis and Microparticle Generation While Inducing Integrin Downregulation and Decreased Aggregability},\r\n booktitle = {International Society for Heart and Lung Transplantation (ISHLT) 2020 Annual Meeting (Canceled)},\r\n address = {Montreal, Canada},\r\n month = {April 22-25},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sweedo, A.; Wise, L. M.; Sheriff, J.; Bluestein, D.; Purdy, J. G.; and Slepian, M. J.\n\n\n \n \n \n \n MCS Hypershear Modulates Platelet Membrane Fluidity, Lipid Species, and is Gender Specific.\n \n \n \n\n\n \n\n\n\n In International Society for Heart and Lung Transplantation (ISHLT) 2020 Annual Meeting (Canceled), Montreal, Canada, April 22-25 2020. \n \n\n\n\n
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@inproceedings{a111,\r\n author = {Sweedo, A. and Wise, L. M. and Sheriff, J. and Bluestein, D. and Purdy, J. G. and Slepian, M. J.},\r\n year = {2020},\r\n title = {MCS Hypershear Modulates Platelet Membrane Fluidity, Lipid Species, and is Gender Specific},\r\n booktitle = {International Society for Heart and Lung Transplantation (ISHLT) 2020 Annual Meeting (Canceled)},\r\n address = {Montreal, Canada},\r\n month = {April 22-25},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Palomares, D.; Italiano, J.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n The “Thrombosis-Bleeding Paradox” of Mechanical Circulatory Support: Shear Stress Promotes Platelet Prothrombosis and Mcroparticle Generation While Inducing Integrin αIIbβ3 Shedding and Decreased Aggregability.\n \n \n \n\n\n \n\n\n\n In AHA Scientific Sessions 2019, Philadelphia, PA, November 16-19 2019. \n \n\n\n\n
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@inproceedings{a105,\r\n author = {Roka-Moiia, Y. and Palomares, D.E. and Italiano, J.E. and Sheriff, J. and Bluestein, D. and Slepian, M.J.},\r\n year = {2019},\r\n title = {The “Thrombosis-Bleeding Paradox” of Mechanical Circulatory Support: Shear Stress Promotes Platelet Prothrombosis and Mcroparticle Generation While Inducing Integrin αIIbβ3 Shedding and Decreased Aggregability},\r\n booktitle = {AHA Scientific Sessions 2019},\r\n address = {Philadelphia, PA},\r\n month = {November 16-19},\r\n project = {lvad; activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Harhash, A.; Muslmani, S.; Sheriff, J.; Bluestein, D.; Kern, K.; and Slepian, M.\n\n\n \n \n \n \n Shear-Mediated Activation Promotes Platelet Procoagulant Activity And Microparticle Generation In Pigs Following Short-Term ECMO Support.\n \n \n \n\n\n \n\n\n\n In 27th ISMCS Annual Meeting, Bologna, Italy, October 21-23 2019. \n \n\n\n\n
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@inproceedings{a102,\r\n author = {Roka-Moiia, Y. and Harhash, A. and Muslmani, S. and Sheriff, J. and Bluestein, D. and Kern, K. and Slepian, M.J.},\r\n year = {2019},\r\n title = {Shear-Mediated Activation Promotes Platelet Procoagulant Activity And Microparticle Generation In Pigs Following Short-Term ECMO Support},\r\n booktitle = {27th ISMCS Annual Meeting},\r\n address = {Bologna, Italy},\r\n month = {October 21-23},\r\n project = {lvad; activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Miller-Gutierrez, S.; Sweedo, A.; Roka-Moiia, Y.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n Shear Stress Induces Spatial and Temporal Alterations of Platelet Membrane Fluidity- Implications for Mechanoceutical Design.\n \n \n \n\n\n \n\n\n\n In BMES Annual Fall Meeting 2019, Philadelphia, PA, October 16-19 2019. \n \n\n\n\n
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@inproceedings{a98,\r\n author = {Miller-Gutierrez, S. and Sweedo, A. and Roka-Moiia, Y. and Sheriff, J. and Bluestein, D. and Slepian, M.J.},\r\n year = {2019},\r\n title = {Shear Stress Induces Spatial and Temporal Alterations of Platelet Membrane Fluidity- Implications for Mechanoceutical Design},\r\n booktitle = {BMES Annual Fall Meeting 2019},\r\n address = {Philadelphia, PA},\r\n month = {October 16-19},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Malone, L.; Bahou, W.; and Bluestein, D.\n\n\n \n \n \n \n Analysis of Shear-Mediated Cord and Adult Platelet Signaling Using Multiplexed Phosphoflow Cytometry.\n \n \n \n\n\n \n\n\n\n In BMES Annual Fall Meeting 2019, Philadelphia, PA, October 16-19 2019. \n \n\n\n\n
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@inproceedings{a97,\r\n author = {Sheriff, J. and Malone, L.E. and Bahou, W.F. and Bluestein, D.},\r\n year = {2019},\r\n title = {Analysis of Shear-Mediated Cord and Adult Platelet Signaling Using Multiplexed Phosphoflow Cytometry},\r\n booktitle = {BMES Annual Fall Meeting 2019},\r\n address = {Philadelphia, PA},\r\n month = {October 16-19},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Harhash, A.; Kern, K.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n Humans and Pigs: Are We That Different? The Effect of Shear Stress and Biochemical Activation on Porcine Platelets.\n \n \n \n\n\n \n\n\n\n In ASAIO 65th Annual Conference, San Francisco, CA, June 26-29 2019. \n \n\n\n\n
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@inproceedings{a91,\r\n author = {Roka-Moiia, Y. and Harhash, A. and Kern, K. and Sheriff, J. and Bluestein, D. and Slepian, M.J.},\r\n year = {2019},\r\n title = {Humans and Pigs: Are We That Different? The Effect of Shear Stress and Biochemical Activation on Porcine Platelets},\r\n booktitle = {ASAIO 65th Annual Conference},\r\n address = {San Francisco, CA},\r\n month = {June 26-29},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sweedo, A.; Roka-Moiia, Y.; Sheriff, J.; Bluestein, D.; Arce, F.; and Slepian, M.\n\n\n \n \n \n \n Shear-Mediated Activation of Platelets is Associated with Global and Regional Changes in Biomechanical Properties: Implications for Mechanism and Therapy.\n \n \n \n\n\n \n\n\n\n In ASAIO 65th Annual Conference, San Francisco, CA, June 26-29 2019. \n \n\n\n\n
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@inproceedings{a90,\r\n author = {Sweedo, A.L. and Roka-Moiia, Y. and Sheriff, J. and Bluestein, D. and Arce, F.T. and Slepian, M.J.},\r\n year = {2019},\r\n title = {Shear-Mediated Activation of Platelets is Associated with Global and Regional Changes in Biomechanical Properties: Implications for Mechanism and Therapy},\r\n booktitle = {ASAIO 65th Annual Conference},\r\n address = {San Francisco, CA},\r\n month = {June 26-29},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n P2Y12 Receptor Agonists: Do They Really Inhibit Shear-Mediated Platelet Activation within MCS?.\n \n \n \n\n\n \n\n\n\n In 39th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Orlando, FL, April 3-6 2019. \n \n\n\n\n
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@inproceedings{a85,\r\n author = {Roka-Moiia, Y. and Sheriff, J. and Bluestein, D. and Slepian, M.J.},\r\n year = {2019},\r\n title = {P2Y12 Receptor Agonists: Do They Really Inhibit Shear-Mediated Platelet Activation within MCS?},\r\n booktitle = {39th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT)},\r\n address = {Orlando, FL},\r\n month = {April 3-6},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sweedo, A.; Wise, L.; Roka-Moiia, Y.; Sheriff, J.; Bluestein, D.; Purdy, J.; and Slepian, M.\n\n\n \n \n \n \n Elevated Shear Associated with MCS Devices Yields Unique Platelet Membrane Lipid Species: Pro-Thrombotic Agonists?.\n \n \n \n\n\n \n\n\n\n In 39th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Orlando, FL, April 3-6 2019. \n \n\n\n\n
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@inproceedings{a84,\r\n author = {Sweedo, A. and Wise, L.M. and Roka-Moiia, Y. and Sheriff, J. and Bluestein, D. and Purdy, J.G. and Slepian, M.J.},\r\n year = {2019},\r\n title = {Elevated Shear Associated with MCS Devices Yields Unique Platelet Membrane Lipid Species: Pro-Thrombotic Agonists?},\r\n booktitle = {39th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT)},\r\n address = {Orlando, FL},\r\n month = {April 3-6},\r\n project = {activation; lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Palomares, D.; Sweedo, A.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n Shear-mediated GPIIb/IIIa-rich platelet microparticle generation: a mechanism validating inability of GPIIb/IIIa blockade to limit MCS thrombosis.\n \n \n \n\n\n \n\n\n\n In 26th Annual Meeting of the International Society for Mechanical Circulatory Support (ISMCS2018), Tokyo, Japan, October 31-November 2 2018. \n \n\n\n\n
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@inproceedings{a71,\r\n author = {Roka-Moiia, Y. and Palomares, D.E. and Sweedo, A. and Sheriff, J. and Bluestein, D. and Slepian, M.J},\r\n year = {2018},\r\n title = {Shear-mediated GPIIb/IIIa-rich platelet microparticle generation: a mechanism validating inability of GPIIb/IIIa blockade to limit MCS thrombosis},\r\n booktitle = {26th Annual Meeting of the International Society for Mechanical Circulatory Support (ISMCS2018)},\r\n address = {Tokyo, Japan},\r\n month = {October 31-November 2},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Zigomolas, A.; Malone, L.; Polehinke, B.; Bahou, W.; and Bluestein, D.\n\n\n \n \n \n \n The role of age in shear-induced platelet activation: effect of calcium on cord and adult platelets.\n \n \n \n\n\n \n\n\n\n In BMES Annual Fall Meeting 2018, Atlanta, GA, October 17-20 2018. \n \n\n\n\n
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@inproceedings{a68,\r\n author = {Sheriff, J. and Zigomolas, A. and Malone, L. and Polehinke, B. and Bahou, W.F. and Bluestein, D.},\r\n year = {2018},\r\n title = {The role of age in shear-induced platelet activation: effect of calcium on cord and adult platelets},\r\n booktitle = {BMES Annual Fall Meeting 2018},\r\n address = {Atlanta, GA},\r\n month = {October 17-20},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sepp, A.; Ngo, A.; Sheriff, J.; Rochelau, A.; Recht, M.; Nieman, M.; Zigomolas, A.; Bluestein, D.; McCarty, O.; and Haley, K.\n\n\n \n \n \n \n Assessment of Platelet Dense Granule Trafficking, P2Y1/P2Y12, and Protease-Activated Receptors Interactions in Neonates Utilizing Whole Blood, Small Volume Assays.\n \n \n \n\n\n \n\n\n\n In BMES Annual Fall Meeting 2018, Atlanta, GA, October 17-20 2018. \n \n\n\n\n
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@inproceedings{a67,\r\n author = {Sepp, A-L. and Ngo, A.T.P. and Sheriff, J. and Rochelau, A.D. and Recht, M. and Nieman, M., Malone, L.E. and Zigomolas, A., Bahou, W.F. and Bluestein, D. and McCarty, O.J.T. and Haley, K.M.},\r\n year = {2018},\r\n title = {Assessment of Platelet Dense Granule Trafficking, P2Y1/P2Y12, and Protease-Activated Receptors Interactions in Neonates Utilizing Whole Blood, Small Volume Assays},\r\n booktitle = {BMES Annual Fall Meeting 2018},\r\n address = {Atlanta, GA},\r\n month = {October 17-20},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Ngo, A.; Sheriff, J.; Jones, K.; Rochelau, A.; Mitrugno, A.; Aslan, J.; Worthington, S.; Cox., A.; Recht, M.; Nieman, M.; Zigomolas, A.; Bluestein, D.; McCarty, O.; and Haley, K.\n\n\n \n \n \n \n Assessment of Neonatal Platelet Granule Trafficking and Shear-Induced Platelet Activation in Neonatal Peripheral and Cord Blood.\n \n \n \n\n\n \n\n\n\n In 64th Annual SSC Meeting of the International Society of Thrombosis and Haemostasis (ISTH), Dublin, Ireland, July 18-21 2018. \n \n\n\n\n
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@inproceedings{a61,\r\n author = {Ngo, A.T.P. and Sheriff, J. and Jones, K.R. and Rochelau, A.D. and Mitrugno, A. and Aslan, J.E. and Worthington, S. and Cox., A. and Recht, M. and Nieman, M., Malone, L.E. and Zigomolas, A., Bahou, W.F. and Bluestein, D. and McCarty, O.J.T. and Haley, K.M.},\r\n year = {2018},\r\n title = {Assessment of Neonatal Platelet Granule Trafficking and Shear-Induced Platelet Activation in Neonatal Peripheral and Cord Blood.},\r\n booktitle = {64th Annual SSC Meeting of the International Society of Thrombosis and Haemostasis (ISTH)},\r\n address = {Dublin, Ireland},\r\n month = {July 18-21},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Consolo, F.; Sheriff, J.; Fiore, G.; Bluestein, D.; Slepian, M.; and Redaelli, A.\n\n\n \n \n \n \n Advanced Bioengineering Approaches For The Comprehensive Analysis Of The Thrombogenic Potential Of Frequency Component Elements Of Hemodynamic Shear Stress Profiles Relevant To Cardiovascular Implantable Therapeutic Devices.\n \n \n \n\n\n \n\n\n\n In 8th World Congress of Biomechanics (WCB), Dublin, Ireland, July 11-12 2018. \n \n\n\n\n
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@inproceedings{a60,\r\n author = {Consolo, F. and Sheriff, J. and Fiore, G. and Bluestein, D. and Slepian, M.J. and Redaelli, A.},\r\n year = {2018},\r\n title = {Advanced Bioengineering Approaches For The Comprehensive Analysis Of The Thrombogenic Potential Of Frequency Component Elements Of Hemodynamic Shear Stress Profiles Relevant To Cardiovascular Implantable Therapeutic Devices},\r\n booktitle = {8th World Congress of Biomechanics (WCB)},\r\n address = {Dublin, Ireland},\r\n month = {July 11-12},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Walk, R.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n The ‘molecular signature’ of dynamic shear-mediated platelet activation in mechanical circulatory support.\n \n \n \n\n\n \n\n\n\n In ASAIO 64th Annual Conference, Washington, DC, June 13-16 2018. \n \n\n\n\n
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@inproceedings{a50,\r\n author = {Roka-Moiia, Y. and Walk, R. and Sheriff, J., and Bluestein, D., and Slepian, M.J.},\r\n year = {2018},\r\n title = {The ‘molecular signature’ of dynamic shear-mediated platelet activation in mechanical circulatory support.},\r\n booktitle = {ASAIO 64th Annual Conference},\r\n address = {Washington, DC},\r\n month = {June 13-16},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sweedo, A.; Saavedra, S.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n Platelet membrane fluidity: a mechanistic component of shear-mediated platelet activation.\n \n \n \n\n\n \n\n\n\n In ASAIO 64th Annual Conference, Washington, DC, June 13-16 2018. \n \n\n\n\n
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@inproceedings{a49,\r\n author = {Sweedo, A., and Saavedra, S.S., and Sheriff, J., and Bluestein, D., and Slepian, M.J.},\r\n year = {2018},\r\n title = {Platelet membrane fluidity: a mechanistic component of shear-mediated platelet activation},\r\n booktitle = {ASAIO 64th Annual Conference},\r\n address = {Washington, DC},\r\n month = {June 13-16},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Tran, P.; Valerio, L.; Hutchinson, M.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n Ticagrelor but not aspirin limits shear-mediated platelet activation.\n \n \n \n\n\n \n\n\n\n In 38th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Nice, France, April 11-14 2018. \n \n\n\n\n
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@inproceedings{a43,\r\n author = {Sheriff, J. and Tran, P.L. and Valerio, L. and Hutchinson, M. and Bluestein, D. and Slepian, M.J.},\r\n year = {2018},\r\n title = {Ticagrelor but not aspirin limits shear-mediated platelet activation.},\r\n booktitle = {38th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT)},\r\n address = {Nice, France},\r\n month = {April 11-14},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Palomares, D.; Sheriff, J.; Bluestein, D.; and Slepian, M.\n\n\n \n \n \n \n MCS shear-mediated platelet activation does not cause integrin GPIIbIIIa activation, rather shedding and microparticle generation.\n \n \n \n\n\n \n\n\n\n In 38th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Nice, France, April 11-14 2018. \n \n\n\n\n
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@inproceedings{a42,\r\n author = {Roka-Moiia, Y. and Palomares, D.E. and Sheriff, J. and Bluestein, D. and Slepian, M.J.},\r\n year = {2018},\r\n title = {MCS shear-mediated platelet activation does not cause integrin GPIIbIIIa activation, rather shedding and microparticle generation.},\r\n booktitle = {38th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT)},\r\n address = {Nice, France},\r\n month = {April 11-14},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Zhang, P.; Sheriff, J.; Gupta, P.; Slepian, M. J.; Deng, Y.; and Bluestein, D.\n\n\n \n \n \n \n A predictive multiscale model for simulating flow-induced platelet activation and aggregation.\n \n \n \n\n\n \n\n\n\n In 25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS), Tucson, AZ, October 15-18 2017. \n \n\n\n\n
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@inproceedings{a39,\r\n author = {Zhang, P. and Sheriff, J. and Gupta, P. and Slepian, M. J. and Deng, Y. and Bluestein, D.},\r\n year = {2017},\r\n title = {A predictive multiscale model for simulating flow-induced platelet activation and aggregation},\r\n booktitle = {25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS)},\r\n address = {Tucson, AZ},\r\n month = {October 15-18},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Palomares, D. E.; Santoleri, A.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Constant shear limits platelet biochemical aggregation promoting integrin GPIIbIIIa shedding and microparticle generation.\n \n \n \n\n\n \n\n\n\n In 25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS), Tucson, AZ, October 15-18 2017. \n \n\n\n\n
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@inproceedings{a38,\r\n author = {Roka-Moiia, Y. and Palomares, D. E. and Santoleri, A. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2017},\r\n title = {Constant shear limits platelet biochemical aggregation promoting integrin GPIIbIIIa shedding and microparticle generation},\r\n booktitle = {25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS)},\r\n address = {Tucson, AZ},\r\n month = {October 15-18},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Roka-Moiia, Y.; Palomares, D. E.; Bajaj, N.; Dimasi, A.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Procoagulant surface exposure: a promising \"early bird\" marker of shear-mediated platelet activation induced by mechanical circulatory support.\n \n \n \n\n\n \n\n\n\n In 25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS), Tucson, AZ, October 15-18 2017. \n \n\n\n\n
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@inproceedings{a36,\r\n author = {Roka-Moiia, Y. and Palomares, D. E. and Bajaj, N. and Dimasi, A. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2017},\r\n title = {Procoagulant surface exposure: a promising "early bird" marker of shear-mediated platelet activation induced by mechanical circulatory support},\r\n booktitle = {25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS)},\r\n address = {Tucson, AZ},\r\n month = {October 15-18},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Gao, W.; Ige, M.; Tran, P. L.; Pietropaolo, M. G.; Redaelli, A.; Slepian, M. J.; and Bluestein, D.\n\n\n \n \n \n \n Platelet lysis, hemolysis, and thrombin generation under ventricular assist device-associated hypershear conditions.\n \n \n \n\n\n \n\n\n\n In 25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS), Tucson, AZ, October 15-18 2017. \n \n\n\n\n
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@inproceedings{a35,\r\n author = {Sheriff, J. and Gao, W. and Ige, M. and Tran, P. L. and Pietropaolo, M. G. and Redaelli, A. and Slepian, M. J. and Bluestein, D.},\r\n year = {2017},\r\n title = {Platelet lysis, hemolysis, and thrombin generation under ventricular assist device-associated hypershear conditions},\r\n booktitle = {25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS)},\r\n address = {Tucson, AZ},\r\n month = {October 15-18},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Tran, P. L.; Hutchinson, M.; Valerio, L.; Brengle, W.; Betterton, E.; Kazui, T.; Khalpey, Z. I.; Sheriff, J.; Bluestein, D.; and Slepian, M. J.\n\n\n \n \n \n \n Platelet activity state assay of a Heartmate II patient with multiple recurrent thrombosis.\n \n \n \n\n\n \n\n\n\n In 25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS), Tucson, AZ, October 15-18 2017. \n \n\n\n\n
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@inproceedings{a34,\r\n author = {Tran, P. L. and Hutchinson, M. and Valerio, L. and Brengle, W. and Betterton, E. and Kazui, T. and Khalpey, Z. I. and Sheriff, J. and Bluestein, D. and Slepian, M. J.},\r\n year = {2017},\r\n title = {Platelet activity state assay of a Heartmate II patient with multiple recurrent thrombosis},\r\n booktitle = {25th Annual Scientific Congress of the International Society of Mechanical Circulatory Support (ISMCS)},\r\n address = {Tucson, AZ},\r\n month = {October 15-18},\r\n project = {activation, lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Malone, L.; Gao, W.; Palomino, N.; Zigomalas, A.; Bahou, W.; and Bluestein, D.\n\n\n \n \n \n \n The role of age in shear-induced platelet activation: comparison of neonatal cord and adult platelets.\n \n \n \n\n\n \n\n\n\n In BMES Annual Fall Meeting 2017, Phoenix, AZ, October 11-14 2017. \n \n\n\n\n
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@inproceedings{a29,\r\n author = {Sheriff, J. and Malone, L. and Gao, W. and Palomino, N. and Zigomalas, A. and Bahou, W. and Bluestein, D.},\r\n year = {2017},\r\n title = {The role of age in shear-induced platelet activation: comparison of neonatal cord and adult platelets},\r\n booktitle = {BMES Annual Fall Meeting 2017},\r\n address = {Phoenix, AZ},\r\n month = {October 11-14},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Goebel, S. G.; Goodin, M. S.; Buck, A. K.; Groszek, J. J.; Wright, N. J.; Blaha, C. M.; Bluestein, D.; Fissell, W. H.; and Roy, S.\n\n\n \n \n \n \n Using wall shear stress and platelet stress accumulation in the design of a bioartificial kidney.\n \n \n \n\n\n \n\n\n\n In ASAIO 63rd Annual Conference, Chicago, IL, June 21-24 2017. \n \n\n\n\n
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@inproceedings{a26,\r\n author = {Goebel, S. G. and Goodin, M. S. and Buck, A. K. and Groszek, J. J. and Wright, N. J. and Blaha, C. M. and Bluestein, D. and Fissell, W. H. and Roy, S.},\r\n year = {2017},\r\n title = {Using wall shear stress and platelet stress accumulation in the design of a bioartificial kidney},\r\n booktitle = {ASAIO 63rd Annual Conference},\r\n address = {Chicago, IL},\r\n month = {June 21-24},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Consolo, F.; Sheriff, J.; Bluestein, D.; Pappalardo, F.; Fiore, G. B.; Slepian, M. J.; and Redaelli, A.\n\n\n \n \n \n \n Analysis of the effect of componenent elements of hemodynamic shear stress profiles on shear-mediated platelet activation in cardiovascular implantable therapeutic devices.\n \n \n \n\n\n \n\n\n\n In ASAIO 63rd Annual Conference, Chicago, IL, June 21-24 2017. \n \n\n\n\n
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@inproceedings{a25,\r\n author = {Consolo, F. and Sheriff, J. and Bluestein, D. and Pappalardo, F. and Fiore, G. B. and Slepian, M. J. and Redaelli, A.},\r\n year = {2017},\r\n title = {Analysis of the effect of componenent elements of hemodynamic shear stress profiles on shear-mediated platelet activation in cardiovascular implantable therapeutic devices},\r\n booktitle = {ASAIO 63rd Annual Conference},\r\n address = {Chicago, IL},\r\n month = {June 21-24},\r\n project = {activation},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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\n \n\n \n \n Sheriff, J.; Tran, P. L.; Valerio, L.; Hutchinson, M.; Brengle, W.; Slepian, M. J.; and Bluestein, D.\n\n\n \n \n \n \n Efficacy of antiplatelet drugs on shear-mediated platelet activation in ventricular assist devices.\n \n \n \n\n\n \n\n\n\n In BMES Annual Fall Meeting 2016, Minneapolis, MN, October 5-8 2016. \n \n\n\n\n
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@inproceedings{a8,\r\n author = {Sheriff, J. and Tran, P. L. and Valerio, L. and Hutchinson, M. and Brengle, W. and Slepian, M. J. and Bluestein, D.},\r\n year = {2016},\r\n title = {Efficacy of antiplatelet drugs on shear-mediated platelet activation in ventricular assist devices},\r\n booktitle = {BMES Annual Fall Meeting 2016},\r\n address = {Minneapolis, MN},\r\n month = {October 5-8},\r\n project = {activation and lvad},\r\n type = {6. Abstracts}\r\n}\r\n\r\n
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