var bibbase_data = {"data":"<img src=\"//bibbase.org/img/ajax-loader.gif\" id=\"spinner\"\n  style=\"display: none;\" alt=\"Loading..\" />\n\n<div id=\"bibbase\">\n\n  <script type=\"text/javascript\">\n    var bibbase = {\n      params: {\"bib\":\"https://api.zotero.org/users/3476755/collections/LE66JLKI/items?key=9MaG4TgseJqKgAFdOazlPFUw&format=bibtex&limit=100\",\"jsonp\":\"1\",\"authorFirst\":\"1\",\"hidemenu\":\"true\",\"commas\":\"true\",\"sort\":\"author_short\",\"groupby\":\"\",\"host\":\"bibbase.org\"},\n      data: [{\"bibtype\":\"misc\",\"type\":\"misc\",\"title\":\"Physiological and ecological tipping points caused by ocean acidification\",\"copyright\":\"https://creativecommons.org/licenses/by/4.0/\",\"url\":\"https://esd.copernicus.org/preprints/esd-2023-24/\",\"doi\":\"10.5194/esd-2023-24\",\"abstract\":\"Abstract. Ocean acidification is predicted to cause profound shifts in many marine ecosystems by impairing the ability of calcareous taxa to calcify and grow, and by influencing the photo-physiology of many others. In both calcifying and non-calcifying taxa, ocean acidification could further impair the ability of marine life to regulate internal pH, and thus metabolic function and/or behaviour. Identifying tipping points at which these effects will occur for different taxa due to the direct impacts of ocean acidification on organism physiology is difficult and they have not adequately been determined for most taxa, nor for ecosystems at higher levels. This is due to the presence of both resistant and sensitive species within most taxa. However, calcifying taxa such as coralline algae, corals, molluscs, and sea urchins appear to be most sensitive to ocean acidification. Conversely, non-calcareous seaweeds, seagrasses, diatoms, cephalopods, and fish tend to be more resistant, or even benefit from the direct effects of ocean acidification. While physiological tipping points of the effects of ocean acidification either do not exist or are not well defined, their direct effects on organism physiology will have flow on indirect effects. These indirect effects will cause ecologically tipping points in the future through changes in competition, herbivory and predation. Evidence for indirect effects and ecological change is mostly taken from benthic ecosystems in warm temperate–tropical locations in situ that have elevated CO2. Species abundances at these locations indicate a shift away from calcifying taxa and towards non-calcareous at high CO2 concentrations. For example, lower abundance of corals and coralline algae, and higher covers of non-calcareous macroalgae, often turfing species, at elevated CO2. However, there are some locations where only minor changes, or no detectable change occurs. Where ecological tipping points do occur, it is usually at locations with naturally elevated pCO2 concentrations of 500 μatm or more, which also corresponds to just under that concentrations where the direct physiological impacts of ocean acidification are detectable on the most sensitive taxa in laboratory research (coralline algae and corals). Collectively, the available data support the concern that ocean acidification will most likely cause ecological change in the near future in most benthic marine ecosystems, with tipping points in some ecosystems at as low as 500 μatm pCO2. However, much more further research is required to more adequately quantify and model the extent of these impacts in order to accurately project future marine ecosystem tipping points under ocean acidification.\",\"urldate\":\"2024-04-04\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Cornwall\"],\"firstnames\":[\"Christopher\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Comeau\"],\"firstnames\":[\"Steeve\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harvey\"],\"firstnames\":[\"Ben\",\"P\"],\"suffixes\":[]}],\"month\":\"September\",\"year\":\"2023\",\"bibtex\":\"@misc{cornwall_physiological_2023,\\n\\ttitle = {Physiological and ecological tipping points caused by ocean acidification},\\n\\tcopyright = {https://creativecommons.org/licenses/by/4.0/},\\n\\turl = {https://esd.copernicus.org/preprints/esd-2023-24/},\\n\\tdoi = {10.5194/esd-2023-24},\\n\\tabstract = {Abstract. Ocean acidification is predicted to cause profound shifts in many marine ecosystems by impairing the ability of calcareous taxa to calcify and grow, and by influencing the photo-physiology of many others. In both calcifying and non-calcifying taxa, ocean acidification could further impair the ability of marine life to regulate internal pH, and thus metabolic function and/or behaviour. Identifying tipping points at which these effects will occur for different taxa due to the direct impacts of ocean acidification on organism physiology is difficult and they have not adequately been determined for most taxa, nor for ecosystems at higher levels. This is due to the presence of both resistant and sensitive species within most taxa. However, calcifying taxa such as coralline algae, corals, molluscs, and sea urchins appear to be most sensitive to ocean acidification. Conversely, non-calcareous seaweeds, seagrasses, diatoms, cephalopods, and fish tend to be more resistant, or even benefit from the direct effects of ocean acidification. While physiological tipping points of the effects of ocean acidification either do not exist or are not well defined, their direct effects on organism physiology will have flow on indirect effects. These indirect effects will cause ecologically tipping points in the future through changes in competition, herbivory and predation. Evidence for indirect effects and ecological change is mostly taken from benthic ecosystems in warm temperate–tropical locations in situ that have elevated CO2. Species abundances at these locations indicate a shift away from calcifying taxa and towards non-calcareous at high CO2 concentrations. For example, lower abundance of corals and coralline algae, and higher covers of non-calcareous macroalgae, often turfing species, at elevated CO2. However, there are some locations where only minor changes, or no detectable change occurs. Where ecological tipping points do occur, it is usually at locations with naturally elevated pCO2 concentrations of 500 μatm or more, which also corresponds to just under that concentrations where the direct physiological impacts of ocean acidification are detectable on the most sensitive taxa in laboratory research (coralline algae and corals). Collectively, the available data support the concern that ocean acidification will most likely cause ecological change in the near future in most benthic marine ecosystems, with tipping points in some ecosystems at as low as 500 μatm pCO2. However, much more further research is required to more adequately quantify and model the extent of these impacts in order to accurately project future marine ecosystem tipping points under ocean acidification.},\\n\\turldate = {2024-04-04},\\n\\tauthor = {Cornwall, Christopher and Comeau, Steeve and Harvey, Ben P},\\n\\tmonth = sep,\\n\\tyear = {2023},\\n}\\n\\n\",\"author_short\":[\"Cornwall, C.\",\"Comeau, S.\",\"Harvey, B. P\"],\"key\":\"cornwall_physiological_2023\",\"id\":\"cornwall_physiological_2023\",\"bibbaseid\":\"cornwall-comeau-harvey-physiologicalandecologicaltippingpointscausedbyoceanacidification-2023\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://esd.copernicus.org/preprints/esd-2023-24/\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate <i>Ciona</i>\",\"volume\":\"14\",\"issn\":\"2045-2322\",\"url\":\"https://www.nature.com/articles/s41598-023-48411-y\",\"doi\":\"10.1038/s41598-023-48411-y\",\"abstract\":\"Abstract Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis is well studied and considered ancestral among metazoans, extrinsic apoptosis is poorly studied outside mammals. Here, we address extrinsic apoptosis in the urochordates Ciona , belonging to the sister group of vertebrates. During metamorphosis, Ciona larvae undergo a tail regression depending on tissue contraction, migration and apoptosis. Apoptosis begin at the tail tip and propagates towards the trunk as a polarized wave. We identified Ci-caspase 8/10 by phylogenetic analysis as homolog to vertebrate caspases 8 and 10 that are the specific initiator of extrinsic apoptosis. We detected Ci-caspase 8/10 expression in Ciona larvae, especially at the tail tip. We showed that chemical inhibition of Ci-caspase 8/10 leads to a delay of tail regression, and Ci-caspase 8/10 loss of function induced an incomplete tail regression. The specificity between apoptotic pathways and initiator caspase suggests that extrinsic apoptosis regulates cell death during the tail regression. Our study presents rare in vivo work on extrinsic apoptosis outside mammals, and contribute to the discussion on its evolutionary history in animals.\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2024-04-04\",\"journal\":\"Scientific Reports\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Krasovec\"],\"firstnames\":[\"Gabriel\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Renaud\"],\"firstnames\":[\"Cécile\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Quéinnec\"],\"firstnames\":[\"Éric\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sasakura\"],\"firstnames\":[\"Yasunori\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chambon\"],\"firstnames\":[\"Jean-Philippe\"],\"suffixes\":[]}],\"month\":\"March\",\"year\":\"2024\",\"pages\":\"5729\",\"bibtex\":\"@article{krasovec_extrinsic_2024,\\n\\ttitle = {Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate \\\\textit{{Ciona}}},\\n\\tvolume = {14},\\n\\tissn = {2045-2322},\\n\\turl = {https://www.nature.com/articles/s41598-023-48411-y},\\n\\tdoi = {10.1038/s41598-023-48411-y},\\n\\tabstract = {Abstract\\n            \\n              Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis is well studied and considered ancestral among metazoans, extrinsic apoptosis is poorly studied outside mammals. Here, we address extrinsic apoptosis in the urochordates\\n              Ciona\\n              , belonging to the sister group of vertebrates. During metamorphosis,\\n              Ciona\\n              larvae undergo a tail regression depending on tissue contraction, migration and apoptosis. Apoptosis begin at the tail tip and propagates towards the trunk as a polarized wave. We identified\\n              Ci-caspase 8/10\\n              by phylogenetic analysis as homolog to vertebrate caspases 8 and 10 that are the specific initiator of extrinsic apoptosis. We detected\\n              Ci-caspase 8/10\\n              expression in\\n              Ciona\\n              larvae, especially at the tail tip. We showed that chemical inhibition of\\n              Ci-caspase 8/10\\n              leads to a delay of tail regression, and\\n              Ci-caspase 8/10\\n              loss of function induced an incomplete tail regression. The specificity between apoptotic pathways and initiator caspase suggests that extrinsic apoptosis regulates cell death during the tail regression. Our study presents rare in vivo work on extrinsic apoptosis outside mammals, and contribute to the discussion on its evolutionary history in animals.},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2024-04-04},\\n\\tjournal = {Scientific Reports},\\n\\tauthor = {Krasovec, Gabriel and Renaud, Cécile and Quéinnec, Éric and Sasakura, Yasunori and Chambon, Jean-Philippe},\\n\\tmonth = mar,\\n\\tyear = {2024},\\n\\tpages = {5729},\\n}\\n\",\"author_short\":[\"Krasovec, G.\",\"Renaud, C.\",\"Quéinnec, É.\",\"Sasakura, Y.\",\"Chambon, J.\"],\"key\":\"krasovec_extrinsic_2024\",\"id\":\"krasovec_extrinsic_2024\",\"bibbaseid\":\"krasovec-renaud-quinnec-sasakura-chambon-extrinsicapoptosisparticipatestotailregressionduringthemetamorphosisofthechordateicionai-2024\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.nature.com/articles/s41598-023-48411-y\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"The neuroendocrine system of <i>Ciona intestinalis</i> Type A, a deuterostome invertebrate and the closest relative of vertebrates\",\"volume\":\"582\",\"issn\":\"03037207\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733\",\"doi\":\"10.1016/j.mce.2023.112122\",\"language\":\"en\",\"urldate\":\"2024-04-04\",\"journal\":\"Molecular and Cellular Endocrinology\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Satake\"],\"firstnames\":[\"Honoo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sasakura\"],\"firstnames\":[\"Yasunori\"],\"suffixes\":[]}],\"month\":\"March\",\"year\":\"2024\",\"pages\":\"112122\",\"bibtex\":\"@article{satake_neuroendocrine_2024,\\n\\ttitle = {The neuroendocrine system of \\\\textit{{Ciona} intestinalis} {Type} {A}, a deuterostome invertebrate and the closest relative of vertebrates},\\n\\tvolume = {582},\\n\\tissn = {03037207},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733},\\n\\tdoi = {10.1016/j.mce.2023.112122},\\n\\tlanguage = {en},\\n\\turldate = {2024-04-04},\\n\\tjournal = {Molecular and Cellular Endocrinology},\\n\\tauthor = {Satake, Honoo and Sasakura, Yasunori},\\n\\tmonth = mar,\\n\\tyear = {2024},\\n\\tpages = {112122},\\n}\\n\\n\",\"author_short\":[\"Satake, H.\",\"Sasakura, Y.\"],\"key\":\"satake_neuroendocrine_2024\",\"id\":\"satake_neuroendocrine_2024\",\"bibbaseid\":\"satake-sasakura-theneuroendocrinesystemoficionaintestinalisitypeaadeuterostomeinvertebrateandtheclosestrelativeofvertebrates-2024\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of <i>Ciona intestinalis</i> type A\",\"volume\":\"14\",\"issn\":\"2045-2322\",\"url\":\"https://www.nature.com/articles/s41598-024-55908-7\",\"doi\":\"10.1038/s41598-024-55908-7\",\"abstract\":\"Abstract The cholecystokinin (CCK)/gastrin family peptides are involved in regulation of feeding and digestion in vertebrates. In the ascidian Ciona intestinalis type A ( Ciona robusta ), cionin, a CCK/gastrin family peptide, has been identified. Cionin is expressed exclusively in the central nervous system (CNS). In contrast, cionin receptor expression has been detected in the CNS, digestive tract, and ovary. Although cionin has been reported to be involved in ovulation, its physiological function in the CNS remains to be investigated. To elucidate its neural function, in the present study, we analyzed the expression of cionin and cionin receptors in the CNS. Cionin was expressed mainly in neurons residing in the anterior region of the cerebral ganglion. In contrast, the gene expressin of the cionin receptor gene CioR1 , was detected in the middle part of the cerebral ganglion and showed a similar expression pattern to that of VACHT , a cholinergic neuron marker gene. Moreover, CioR1 was found to be expressed in cholinergic neurons. Consequently, these results suggest that cionin interacts with cholinergic neurons as a neurotransmitter or neuromodulator via CioR1. This study provides insights into a biological role of a CCK/gastrin family peptide in the CNS of ascidians.\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2024-04-04\",\"journal\":\"Scientific Reports\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Taniguchi\"],\"firstnames\":[\"Shiho\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Nakayama\"],\"firstnames\":[\"Satoshi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Iguchi\"],\"firstnames\":[\"Rin\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sasakura\"],\"firstnames\":[\"Yasunori\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Satake\"],\"firstnames\":[\"Honoo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Wada\"],\"firstnames\":[\"Shuichi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Suzuki\"],\"firstnames\":[\"Nobuo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ogasawara\"],\"firstnames\":[\"Michio\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sekiguchi\"],\"firstnames\":[\"Toshio\"],\"suffixes\":[]}],\"month\":\"March\",\"year\":\"2024\",\"keywords\":\"wrongWada\",\"pages\":\"6277\",\"bibtex\":\"@article{taniguchi_distribution_2024,\\n\\ttitle = {Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of \\\\textit{{Ciona} intestinalis} type {A}},\\n\\tvolume = {14},\\n\\tissn = {2045-2322},\\n\\turl = {https://www.nature.com/articles/s41598-024-55908-7},\\n\\tdoi = {10.1038/s41598-024-55908-7},\\n\\tabstract = {Abstract\\n            \\n              The cholecystokinin (CCK)/gastrin family peptides are involved in regulation of feeding and digestion in vertebrates. In the ascidian\\n              Ciona intestinalis\\n              type A (\\n              Ciona robusta\\n              ), cionin, a CCK/gastrin family peptide, has been identified. Cionin is expressed exclusively in the central nervous system (CNS). In contrast, cionin receptor expression has been detected in the CNS, digestive tract, and ovary. Although cionin has been reported to be involved in ovulation, its physiological function in the CNS remains to be investigated. To elucidate its neural function, in the present study, we analyzed the expression of cionin and cionin receptors in the CNS. Cionin was expressed mainly in neurons residing in the anterior region of the cerebral ganglion. In contrast, the gene expressin of the cionin receptor gene\\n              CioR1\\n              , was detected in the middle part of the cerebral ganglion and showed a similar expression pattern to that of\\n              VACHT\\n              , a cholinergic neuron marker gene. Moreover,\\n              CioR1\\n              was found to be expressed in cholinergic neurons. Consequently, these results suggest that cionin interacts with cholinergic neurons as a neurotransmitter or neuromodulator via CioR1. This study provides insights into a biological role of a CCK/gastrin family peptide in the CNS of ascidians.},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2024-04-04},\\n\\tjournal = {Scientific Reports},\\n\\tauthor = {Taniguchi, Shiho and Nakayama, Satoshi and Iguchi, Rin and Sasakura, Yasunori and Satake, Honoo and Wada, Shuichi and Suzuki, Nobuo and Ogasawara, Michio and Sekiguchi, Toshio},\\n\\tmonth = mar,\\n\\tyear = {2024},\\n\\tkeywords = {wrongWada},\\n\\tpages = {6277},\\n}\\n\\n\",\"author_short\":[\"Taniguchi, S.\",\"Nakayama, S.\",\"Iguchi, R.\",\"Sasakura, Y.\",\"Satake, H.\",\"Wada, S.\",\"Suzuki, N.\",\"Ogasawara, M.\",\"Sekiguchi, T.\"],\"key\":\"taniguchi_distribution_2024\",\"id\":\"taniguchi_distribution_2024\",\"bibbaseid\":\"taniguchi-nakayama-iguchi-sasakura-satake-wada-suzuki-ogasawara-etal-distributionofcioninacholecystokiningastrinfamilypeptideanditsreceptorinthecentralnervoussystemoficionaintestinalisitypea-2024\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.nature.com/articles/s41598-024-55908-7\"},\"keyword\":[\"wrongWada\"],\"metadata\":{\"authorlinks\":{}},\"html\":\"\"}],\n      metadata: {\"authorlinks\":{}},\n      ownerID: undefined\n    };\n  </script>\n\n  <script type=\"text/javascript\">\n  var site$;\n  if (typeof $ != 'undefined') {\n    console.log('existing jquery: storing and then restoring');\n    site$ = $;\n    $ = null;\n  }\n  </script>\n\n  <script src=\"https://ajax.googleapis.com/ajax/libs/jquery/2.2.4/jquery.min.js\">\n  </script>\n  <script type=\"text/javascript\">\n  if (site$) {\n    console.log('existing jquery: avoiding conflict and restoring');\n    bb$ = $.noConflict(true);\n    $ = site$;\n  } else {\n    bb$ = $;\n  }\n  </script>\n\n  <script src=\"//bibbase.org/js/bibbase.min.js\"\n          type=\"text/javascript\">\n  </script>\n\n  <script type=\"text/javascript\"\n          src=\"https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.1/MathJax.js?config=TeX-AMS-MML_HTMLorMML\">\n  </script>\n  <script type=\"text/x-mathjax-config\">\n    MathJax.Hub.Config({tex2jax: {inlineMath: [['$','$'], ['\\\\(','\\\\)']]},\n                        skipTags: [\"body\"],\n                        processClass: \"bibbase_paper\"});\n  </script>\n\n  <style>\n  @media print {\n    .dontprint {\n        display: none !important;\n    }\n\n  .bibbase_group {\n    background-color: #E0E0E0;\n    font-style: italic;\n    font-size: larger;\n    text-shadow: 0px 0px 3px #FFFFFF;\n    border-radius: 4px 4px 4px 4px;\n    -moz-border-radius: 4px 4px 4px 4px;\n    -webkit-border-radius: 4px;\n    padding: 5px 40px 5px;\n    margin-top: 10px;\n    margin-bottom: 5px;\n    cursor: pointer;\n  }\n\n  .bibbase_paper {\n    margin-bottom: 5px;\n  }\n\n  }\n  </style>\n\n  \n  <div style=\"float: right; margin-right: 10px; margin-top: 10px; text-align: right; font-size: 12px\">\n    generated by\n    <a href=\"//bibbase.org\"\n       onclick=\"trackOutboundLink('bibbase', 'logo clicked', window.location.href, '//bibbase.org'); return false;\">\n      <img src=\"//bibbase.org/img/logo.svg\"\n           style=\"vertical-align: middle; margin-left: 3px; height: 16px;\"/\n           alt=\"bibbase.org\"\n           title=\"BibBase – The easiest way to maintain your publications page.\"\n        ></a>\n    \n  </div>\n  \n\n  <div id=\"bibbase_header\" class=\"dontprint\" style=\"display: none\">\n\n    <ul class=\"nav nav-pills\" style=\"margin: 0px;\">\n\n      <li class=\"dropdown\" id=\"groupby_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\">\n          Group by\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li class=\"groupby year\"><a onclick=\"groupby('year')\">\n            Year</a>\n        </li>\n        <li class=\"groupby author\"><a onclick=\"groupby('author_short')\">\n            Author</a>\n        </li>\n        <li class=\"groupby type\"><a onclick=\"groupby('type')\">\n            Type</a>\n        </li>\n        <li class=\"groupby keyword\"><a onclick=\"groupby('keyword')\">\n            Keyword</a>\n        </li>\n        <li class=\"groupby downloads\"><a onclick=\"groupby('downloads')\">\n            Downloads</a>\n        </li>\n      </ul>\n      </li>\n\n\n      <li class=\"dropdown\" id=\"menu_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\" alt=\"controls\">\n          <i class=\"fa fa-reorder\" alt=\"controls\"></i>\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li>\n          <a onclick=\"toggleAll()\">\n            <i class=\"fa fa-chevron-down fa-fw\"></i> Expand/Collapse All\n          </a>\n        </li>\n        <li>\n          <a download=\"items\" href=\"data:text/bibtex;base64,@misc{cornwall_physiological_2023,
	title = {Physiological and ecological tipping points caused by ocean acidification},
	copyright = {https://creativecommons.org/licenses/by/4.0/},
	url = {https://esd.copernicus.org/preprints/esd-2023-24/},
	doi = {10.5194/esd-2023-24},
	abstract = {Abstract. Ocean acidification is predicted to cause profound shifts in many marine ecosystems by impairing the ability of calcareous taxa to calcify and grow, and by influencing the photo-physiology of many others. In both calcifying and non-calcifying taxa, ocean acidification could further impair the ability of marine life to regulate internal pH, and thus metabolic function and/or behaviour. Identifying tipping points at which these effects will occur for different taxa due to the direct impacts of ocean acidification on organism physiology is difficult and they have not adequately been determined for most taxa, nor for ecosystems at higher levels. This is due to the presence of both resistant and sensitive species within most taxa. However, calcifying taxa such as coralline algae, corals, molluscs, and sea urchins appear to be most sensitive to ocean acidification. Conversely, non-calcareous seaweeds, seagrasses, diatoms, cephalopods, and fish tend to be more resistant, or even benefit from the direct effects of ocean acidification. While physiological tipping points of the effects of ocean acidification either do not exist or are not well defined, their direct effects on organism physiology will have flow on indirect effects. These indirect effects will cause ecologically tipping points in the future through changes in competition, herbivory and predation. Evidence for indirect effects and ecological change is mostly taken from benthic ecosystems in warm temperate–tropical locations in situ that have elevated CO2. Species abundances at these locations indicate a shift away from calcifying taxa and towards non-calcareous at high CO2 concentrations. For example, lower abundance of corals and coralline algae, and higher covers of non-calcareous macroalgae, often turfing species, at elevated CO2. However, there are some locations where only minor changes, or no detectable change occurs. Where ecological tipping points do occur, it is usually at locations with naturally elevated pCO2 concentrations of 500 μatm or more, which also corresponds to just under that concentrations where the direct physiological impacts of ocean acidification are detectable on the most sensitive taxa in laboratory research (coralline algae and corals). Collectively, the available data support the concern that ocean acidification will most likely cause ecological change in the near future in most benthic marine ecosystems, with tipping points in some ecosystems at as low as 500 μatm pCO2. However, much more further research is required to more adequately quantify and model the extent of these impacts in order to accurately project future marine ecosystem tipping points under ocean acidification.},
	urldate = {2024-04-04},
	author = {Cornwall, Christopher and Comeau, Steeve and Harvey, Ben P},
	month = sep,
	year = {2023},
}



@article{krasovec_extrinsic_2024,
	title = {Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate \textit{{Ciona}}},
	volume = {14},
	issn = {2045-2322},
	url = {https://www.nature.com/articles/s41598-023-48411-y},
	doi = {10.1038/s41598-023-48411-y},
	abstract = {Abstract
            
              Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis is well studied and considered ancestral among metazoans, extrinsic apoptosis is poorly studied outside mammals. Here, we address extrinsic apoptosis in the urochordates
              Ciona
              , belonging to the sister group of vertebrates. During metamorphosis,
              Ciona
              larvae undergo a tail regression depending on tissue contraction, migration and apoptosis. Apoptosis begin at the tail tip and propagates towards the trunk as a polarized wave. We identified
              Ci-caspase 8/10
              by phylogenetic analysis as homolog to vertebrate caspases 8 and 10 that are the specific initiator of extrinsic apoptosis. We detected
              Ci-caspase 8/10
              expression in
              Ciona
              larvae, especially at the tail tip. We showed that chemical inhibition of
              Ci-caspase 8/10
              leads to a delay of tail regression, and
              Ci-caspase 8/10
              loss of function induced an incomplete tail regression. The specificity between apoptotic pathways and initiator caspase suggests that extrinsic apoptosis regulates cell death during the tail regression. Our study presents rare in vivo work on extrinsic apoptosis outside mammals, and contribute to the discussion on its evolutionary history in animals.},
	language = {en},
	number = {1},
	urldate = {2024-04-04},
	journal = {Scientific Reports},
	author = {Krasovec, Gabriel and Renaud, Cécile and Quéinnec, Éric and Sasakura, Yasunori and Chambon, Jean-Philippe},
	month = mar,
	year = {2024},
	pages = {5729},
}


@article{satake_neuroendocrine_2024,
	title = {The neuroendocrine system of \textit{{Ciona} intestinalis} {Type} {A}, a deuterostome invertebrate and the closest relative of vertebrates},
	volume = {582},
	issn = {03037207},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733},
	doi = {10.1016/j.mce.2023.112122},
	language = {en},
	urldate = {2024-04-04},
	journal = {Molecular and Cellular Endocrinology},
	author = {Satake, Honoo and Sasakura, Yasunori},
	month = mar,
	year = {2024},
	pages = {112122},
}



@article{taniguchi_distribution_2024,
	title = {Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of \textit{{Ciona} intestinalis} type {A}},
	volume = {14},
	issn = {2045-2322},
	url = {https://www.nature.com/articles/s41598-024-55908-7},
	doi = {10.1038/s41598-024-55908-7},
	abstract = {Abstract
            
              The cholecystokinin (CCK)/gastrin family peptides are involved in regulation of feeding and digestion in vertebrates. In the ascidian
              Ciona intestinalis
              type A (
              Ciona robusta
              ), cionin, a CCK/gastrin family peptide, has been identified. Cionin is expressed exclusively in the central nervous system (CNS). In contrast, cionin receptor expression has been detected in the CNS, digestive tract, and ovary. Although cionin has been reported to be involved in ovulation, its physiological function in the CNS remains to be investigated. To elucidate its neural function, in the present study, we analyzed the expression of cionin and cionin receptors in the CNS. Cionin was expressed mainly in neurons residing in the anterior region of the cerebral ganglion. In contrast, the gene expressin of the cionin receptor gene
              CioR1
              , was detected in the middle part of the cerebral ganglion and showed a similar expression pattern to that of
              VACHT
              , a cholinergic neuron marker gene. Moreover,
              CioR1
              was found to be expressed in cholinergic neurons. Consequently, these results suggest that cionin interacts with cholinergic neurons as a neurotransmitter or neuromodulator via CioR1. This study provides insights into a biological role of a CCK/gastrin family peptide in the CNS of ascidians.},
	language = {en},
	number = {1},
	urldate = {2024-04-04},
	journal = {Scientific Reports},
	author = {Taniguchi, Shiho and Nakayama, Satoshi and Iguchi, Rin and Sasakura, Yasunori and Satake, Honoo and Wada, Shuichi and Suzuki, Nobuo and Ogasawara, Michio and Sekiguchi, Toshio},
	month = mar,
	year = {2024},
	keywords = {wrongWada},
	pages = {6277},
}

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P\n</span>\n\n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://esd.copernicus.org/preprints/esd-2023-24/\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'cornwall-comeau-harvey-physiologicalandecologicaltippingpointscausedbyoceanacidification-2023', 'https://esd.copernicus.org/preprints/esd-2023-24/', event);\">\n    Physiological and ecological tipping points caused by ocean acidification.\n  </a>\n  \n  \n  \n</span>\n\n  \n\n</span>\n\n  September 2023.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://esd.copernicus.org/preprints/esd-2023-24/\"\n     onclick=\"log_download('cornwall-comeau-harvey-physiologicalandecologicaltippingpointscausedbyoceanacidification-2023', 'https://esd.copernicus.org/preprints/esd-2023-24/', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Physiological and ecological tipping points caused by ocean acidification [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.5194/esd-2023-24\"\n     onclick=\"log_download('cornwall-comeau-harvey-physiologicalandecologicaltippingpointscausedbyoceanacidification-2023', 'http://doi.org/10.5194/esd-2023-24', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/cornwall-comeau-harvey-physiologicalandecologicaltippingpointscausedbyoceanacidification-2023\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('cornwall-comeau-harvey-physiologicalandecologicaltippingpointscausedbyoceanacidification-2023')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@misc{cornwall_physiological_2023,\n\ttitle = {Physiological and ecological tipping points caused by ocean acidification},\n\tcopyright = {https://creativecommons.org/licenses/by/4.0/},\n\turl = {https://esd.copernicus.org/preprints/esd-2023-24/},\n\tdoi = {10.5194/esd-2023-24},\n\tabstract = {Abstract. Ocean acidification is predicted to cause profound shifts in many marine ecosystems by impairing the ability of calcareous taxa to calcify and grow, and by influencing the photo-physiology of many others. In both calcifying and non-calcifying taxa, ocean acidification could further impair the ability of marine life to regulate internal pH, and thus metabolic function and/or behaviour. Identifying tipping points at which these effects will occur for different taxa due to the direct impacts of ocean acidification on organism physiology is difficult and they have not adequately been determined for most taxa, nor for ecosystems at higher levels. This is due to the presence of both resistant and sensitive species within most taxa. However, calcifying taxa such as coralline algae, corals, molluscs, and sea urchins appear to be most sensitive to ocean acidification. Conversely, non-calcareous seaweeds, seagrasses, diatoms, cephalopods, and fish tend to be more resistant, or even benefit from the direct effects of ocean acidification. While physiological tipping points of the effects of ocean acidification either do not exist or are not well defined, their direct effects on organism physiology will have flow on indirect effects. These indirect effects will cause ecologically tipping points in the future through changes in competition, herbivory and predation. Evidence for indirect effects and ecological change is mostly taken from benthic ecosystems in warm temperate–tropical locations in situ that have elevated CO2. Species abundances at these locations indicate a shift away from calcifying taxa and towards non-calcareous at high CO2 concentrations. For example, lower abundance of corals and coralline algae, and higher covers of non-calcareous macroalgae, often turfing species, at elevated CO2. However, there are some locations where only minor changes, or no detectable change occurs. Where ecological tipping points do occur, it is usually at locations with naturally elevated pCO2 concentrations of 500 μatm or more, which also corresponds to just under that concentrations where the direct physiological impacts of ocean acidification are detectable on the most sensitive taxa in laboratory research (coralline algae and corals). Collectively, the available data support the concern that ocean acidification will most likely cause ecological change in the near future in most benthic marine ecosystems, with tipping points in some ecosystems at as low as 500 μatm pCO2. However, much more further research is required to more adequately quantify and model the extent of these impacts in order to accurately project future marine ecosystem tipping points under ocean acidification.},\n\turldate = {2024-04-04},\n\tauthor = {Cornwall, Christopher and Comeau, Steeve and Harvey, Ben P},\n\tmonth = sep,\n\tyear = {2023},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Abstract. Ocean acidification is predicted to cause profound shifts in many marine ecosystems by impairing the ability of calcareous taxa to calcify and grow, and by influencing the photo-physiology of many others. In both calcifying and non-calcifying taxa, ocean acidification could further impair the ability of marine life to regulate internal pH, and thus metabolic function and/or behaviour. Identifying tipping points at which these effects will occur for different taxa due to the direct impacts of ocean acidification on organism physiology is difficult and they have not adequately been determined for most taxa, nor for ecosystems at higher levels. This is due to the presence of both resistant and sensitive species within most taxa. However, calcifying taxa such as coralline algae, corals, molluscs, and sea urchins appear to be most sensitive to ocean acidification. Conversely, non-calcareous seaweeds, seagrasses, diatoms, cephalopods, and fish tend to be more resistant, or even benefit from the direct effects of ocean acidification. While physiological tipping points of the effects of ocean acidification either do not exist or are not well defined, their direct effects on organism physiology will have flow on indirect effects. These indirect effects will cause ecologically tipping points in the future through changes in competition, herbivory and predation. Evidence for indirect effects and ecological change is mostly taken from benthic ecosystems in warm temperate–tropical locations in situ that have elevated CO2. Species abundances at these locations indicate a shift away from calcifying taxa and towards non-calcareous at high CO2 concentrations. For example, lower abundance of corals and coralline algae, and higher covers of non-calcareous macroalgae, often turfing species, at elevated CO2. However, there are some locations where only minor changes, or no detectable change occurs. Where ecological tipping points do occur, it is usually at locations with naturally elevated pCO2 concentrations of 500 μatm or more, which also corresponds to just under that concentrations where the direct physiological impacts of ocean acidification are detectable on the most sensitive taxa in laboratory research (coralline algae and corals). Collectively, the available data support the concern that ocean acidification will most likely cause ecological change in the near future in most benthic marine ecosystems, with tipping points in some ecosystems at as low as 500 μatm pCO2. However, much more further research is required to more adequately quantify and model the extent of these impacts in order to accurately project future marine ecosystem tipping points under ocean acidification.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"krasovec-renaud-quinnec-sasakura-chambon-extrinsicapoptosisparticipatestotailregressionduringthemetamorphosisofthechordateicionai-2024\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_author\">\n  Krasovec, G., Renaud, C., Quéinnec, É., Sasakura, Y.,  &amp; Chambon, J.\n</span>\n\n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.nature.com/articles/s41598-023-48411-y\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'krasovec-renaud-quinnec-sasakura-chambon-extrinsicapoptosisparticipatestotailregressionduringthemetamorphosisofthechordateicionai-2024', 'https://www.nature.com/articles/s41598-023-48411-y', event);\">\n    Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate <i>Ciona</i>.\n  </a>\n  \n  \n  \n</span>\n\n  \n\n</span>\n\n  <i>Scientific Reports</i>, 14(1): 5729. March 2024.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.nature.com/articles/s41598-023-48411-y\"\n     onclick=\"log_download('krasovec-renaud-quinnec-sasakura-chambon-extrinsicapoptosisparticipatestotailregressionduringthemetamorphosisofthechordateicionai-2024', 'https://www.nature.com/articles/s41598-023-48411-y', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate &lt;i&gt;Ciona&lt;/i&gt; [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1038/s41598-023-48411-y\"\n     onclick=\"log_download('krasovec-renaud-quinnec-sasakura-chambon-extrinsicapoptosisparticipatestotailregressionduringthemetamorphosisofthechordateicionai-2024', 'http://doi.org/10.1038/s41598-023-48411-y', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/krasovec-renaud-quinnec-sasakura-chambon-extrinsicapoptosisparticipatestotailregressionduringthemetamorphosisofthechordateicionai-2024\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('krasovec-renaud-quinnec-sasakura-chambon-extrinsicapoptosisparticipatestotailregressionduringthemetamorphosisofthechordateicionai-2024')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{krasovec_extrinsic_2024,\n\ttitle = {Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate \\textit{{Ciona}}},\n\tvolume = {14},\n\tissn = {2045-2322},\n\turl = {https://www.nature.com/articles/s41598-023-48411-y},\n\tdoi = {10.1038/s41598-023-48411-y},\n\tabstract = {Abstract\n            \n              Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis is well studied and considered ancestral among metazoans, extrinsic apoptosis is poorly studied outside mammals. Here, we address extrinsic apoptosis in the urochordates\n              Ciona\n              , belonging to the sister group of vertebrates. During metamorphosis,\n              Ciona\n              larvae undergo a tail regression depending on tissue contraction, migration and apoptosis. Apoptosis begin at the tail tip and propagates towards the trunk as a polarized wave. We identified\n              Ci-caspase 8/10\n              by phylogenetic analysis as homolog to vertebrate caspases 8 and 10 that are the specific initiator of extrinsic apoptosis. We detected\n              Ci-caspase 8/10\n              expression in\n              Ciona\n              larvae, especially at the tail tip. We showed that chemical inhibition of\n              Ci-caspase 8/10\n              leads to a delay of tail regression, and\n              Ci-caspase 8/10\n              loss of function induced an incomplete tail regression. The specificity between apoptotic pathways and initiator caspase suggests that extrinsic apoptosis regulates cell death during the tail regression. Our study presents rare in vivo work on extrinsic apoptosis outside mammals, and contribute to the discussion on its evolutionary history in animals.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2024-04-04},\n\tjournal = {Scientific Reports},\n\tauthor = {Krasovec, Gabriel and Renaud, Cécile and Quéinnec, Éric and Sasakura, Yasunori and Chambon, Jean-Philippe},\n\tmonth = mar,\n\tyear = {2024},\n\tpages = {5729},\n}\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Abstract Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis is well studied and considered ancestral among metazoans, extrinsic apoptosis is poorly studied outside mammals. Here, we address extrinsic apoptosis in the urochordates Ciona , belonging to the sister group of vertebrates. During metamorphosis, Ciona larvae undergo a tail regression depending on tissue contraction, migration and apoptosis. Apoptosis begin at the tail tip and propagates towards the trunk as a polarized wave. We identified Ci-caspase 8/10 by phylogenetic analysis as homolog to vertebrate caspases 8 and 10 that are the specific initiator of extrinsic apoptosis. We detected Ci-caspase 8/10 expression in Ciona larvae, especially at the tail tip. We showed that chemical inhibition of Ci-caspase 8/10 leads to a delay of tail regression, and Ci-caspase 8/10 loss of function induced an incomplete tail regression. The specificity between apoptotic pathways and initiator caspase suggests that extrinsic apoptosis regulates cell death during the tail regression. Our study presents rare in vivo work on extrinsic apoptosis outside mammals, and contribute to the discussion on its evolutionary history in animals.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"satake-sasakura-theneuroendocrinesystemoficionaintestinalisitypeaadeuterostomeinvertebrateandtheclosestrelativeofvertebrates-2024\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_author\">\n  Satake, H.,  &amp; Sasakura, Y.\n</span>\n\n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'satake-sasakura-theneuroendocrinesystemoficionaintestinalisitypeaadeuterostomeinvertebrateandtheclosestrelativeofvertebrates-2024', 'https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733', event);\">\n    The neuroendocrine system of <i>Ciona intestinalis</i> Type A, a deuterostome invertebrate and the closest relative of vertebrates.\n  </a>\n  \n  \n  \n</span>\n\n  \n\n</span>\n\n  <i>Molecular and Cellular Endocrinology</i>, 582: 112122. March 2024.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733\"\n     onclick=\"log_download('satake-sasakura-theneuroendocrinesystemoficionaintestinalisitypeaadeuterostomeinvertebrateandtheclosestrelativeofvertebrates-2024', 'https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"The neuroendocrine system of &lt;i&gt;Ciona intestinalis&lt;/i&gt; Type A, a deuterostome invertebrate and the closest relative of vertebrates [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.mce.2023.112122\"\n     onclick=\"log_download('satake-sasakura-theneuroendocrinesystemoficionaintestinalisitypeaadeuterostomeinvertebrateandtheclosestrelativeofvertebrates-2024', 'http://doi.org/10.1016/j.mce.2023.112122', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/satake-sasakura-theneuroendocrinesystemoficionaintestinalisitypeaadeuterostomeinvertebrateandtheclosestrelativeofvertebrates-2024\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('satake-sasakura-theneuroendocrinesystemoficionaintestinalisitypeaadeuterostomeinvertebrateandtheclosestrelativeofvertebrates-2024')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{satake_neuroendocrine_2024,\n\ttitle = {The neuroendocrine system of \\textit{{Ciona} intestinalis} {Type} {A}, a deuterostome invertebrate and the closest relative of vertebrates},\n\tvolume = {582},\n\tissn = {03037207},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0303720723002733},\n\tdoi = {10.1016/j.mce.2023.112122},\n\tlanguage = {en},\n\turldate = {2024-04-04},\n\tjournal = {Molecular and Cellular Endocrinology},\n\tauthor = {Satake, Honoo and Sasakura, Yasunori},\n\tmonth = mar,\n\tyear = {2024},\n\tpages = {112122},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"taniguchi-nakayama-iguchi-sasakura-satake-wada-suzuki-ogasawara-etal-distributionofcioninacholecystokiningastrinfamilypeptideanditsreceptorinthecentralnervoussystemoficionaintestinalisitypea-2024\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_author\">\n  Taniguchi, S., Nakayama, S., Iguchi, R., Sasakura, Y., Satake, H., Wada, S., Suzuki, N., Ogasawara, M.,  &amp; Sekiguchi, T.\n</span>\n\n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.nature.com/articles/s41598-024-55908-7\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'taniguchi-nakayama-iguchi-sasakura-satake-wada-suzuki-ogasawara-etal-distributionofcioninacholecystokiningastrinfamilypeptideanditsreceptorinthecentralnervoussystemoficionaintestinalisitypea-2024', 'https://www.nature.com/articles/s41598-024-55908-7', event);\">\n    Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of <i>Ciona intestinalis</i> type A.\n  </a>\n  \n  \n  \n</span>\n\n  \n\n</span>\n\n  <i>Scientific Reports</i>, 14(1): 6277. March 2024.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.nature.com/articles/s41598-024-55908-7\"\n     onclick=\"log_download('taniguchi-nakayama-iguchi-sasakura-satake-wada-suzuki-ogasawara-etal-distributionofcioninacholecystokiningastrinfamilypeptideanditsreceptorinthecentralnervoussystemoficionaintestinalisitypea-2024', 'https://www.nature.com/articles/s41598-024-55908-7', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of &lt;i&gt;Ciona intestinalis&lt;/i&gt; type A [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1038/s41598-024-55908-7\"\n     onclick=\"log_download('taniguchi-nakayama-iguchi-sasakura-satake-wada-suzuki-ogasawara-etal-distributionofcioninacholecystokiningastrinfamilypeptideanditsreceptorinthecentralnervoussystemoficionaintestinalisitypea-2024', 'http://doi.org/10.1038/s41598-024-55908-7', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/taniguchi-nakayama-iguchi-sasakura-satake-wada-suzuki-ogasawara-etal-distributionofcioninacholecystokiningastrinfamilypeptideanditsreceptorinthecentralnervoussystemoficionaintestinalisitypea-2024\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('taniguchi-nakayama-iguchi-sasakura-satake-wada-suzuki-ogasawara-etal-distributionofcioninacholecystokiningastrinfamilypeptideanditsreceptorinthecentralnervoussystemoficionaintestinalisitypea-2024')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{taniguchi_distribution_2024,\n\ttitle = {Distribution of cionin, a cholecystokinin/gastrin family peptide, and its receptor in the central nervous system of \\textit{{Ciona} intestinalis} type {A}},\n\tvolume = {14},\n\tissn = {2045-2322},\n\turl = {https://www.nature.com/articles/s41598-024-55908-7},\n\tdoi = {10.1038/s41598-024-55908-7},\n\tabstract = {Abstract\n            \n              The cholecystokinin (CCK)/gastrin family peptides are involved in regulation of feeding and digestion in vertebrates. In the ascidian\n              Ciona intestinalis\n              type A (\n              Ciona robusta\n              ), cionin, a CCK/gastrin family peptide, has been identified. Cionin is expressed exclusively in the central nervous system (CNS). In contrast, cionin receptor expression has been detected in the CNS, digestive tract, and ovary. Although cionin has been reported to be involved in ovulation, its physiological function in the CNS remains to be investigated. To elucidate its neural function, in the present study, we analyzed the expression of cionin and cionin receptors in the CNS. Cionin was expressed mainly in neurons residing in the anterior region of the cerebral ganglion. In contrast, the gene expressin of the cionin receptor gene\n              CioR1\n              , was detected in the middle part of the cerebral ganglion and showed a similar expression pattern to that of\n              VACHT\n              , a cholinergic neuron marker gene. Moreover,\n              CioR1\n              was found to be expressed in cholinergic neurons. Consequently, these results suggest that cionin interacts with cholinergic neurons as a neurotransmitter or neuromodulator via CioR1. This study provides insights into a biological role of a CCK/gastrin family peptide in the CNS of ascidians.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2024-04-04},\n\tjournal = {Scientific Reports},\n\tauthor = {Taniguchi, Shiho and Nakayama, Satoshi and Iguchi, Rin and Sasakura, Yasunori and Satake, Honoo and Wada, Shuichi and Suzuki, Nobuo and Ogasawara, Michio and Sekiguchi, Toshio},\n\tmonth = mar,\n\tyear = {2024},\n\tkeywords = {wrongWada},\n\tpages = {6277},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Abstract The cholecystokinin (CCK)/gastrin family peptides are involved in regulation of feeding and digestion in vertebrates. In the ascidian Ciona intestinalis type A ( Ciona robusta ), cionin, a CCK/gastrin family peptide, has been identified. Cionin is expressed exclusively in the central nervous system (CNS). In contrast, cionin receptor expression has been detected in the CNS, digestive tract, and ovary. Although cionin has been reported to be involved in ovulation, its physiological function in the CNS remains to be investigated. To elucidate its neural function, in the present study, we analyzed the expression of cionin and cionin receptors in the CNS. Cionin was expressed mainly in neurons residing in the anterior region of the cerebral ganglion. In contrast, the gene expressin of the cionin receptor gene CioR1 , was detected in the middle part of the cerebral ganglion and showed a similar expression pattern to that of VACHT , a cholinergic neuron marker gene. Moreover, CioR1 was found to be expressed in cholinergic neurons. Consequently, these results suggest that cionin interacts with cholinergic neurons as a neurotransmitter or neuromodulator via CioR1. This study provides insights into a biological role of a CCK/gastrin family peptide in the CNS of ascidians.\n</div>\n\n\n</div>\n\n\n\n\n\n  </div>\n\n\n  <!-- Modal -->\n\n  <!-- <iframe id=\"bibbase_network_frame\" -->\n  <!--         src=\"//bibbase.org/network/control\" -->\n  <!--         style=\"display: none;\"> -->\n  <!-- </iframe> -->\n\n</div>\n"}; document.write(bibbase_data.data);