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\n  \n 2018\n \n \n (3)\n \n \n
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\n \n\n \n \n \n \n \n Evolution of Survival in Cardiac Arrest with Age in Elderly Patients: Is Resuscitation a Dead End?.\n \n \n \n\n\n \n Segal, N.; di Pompéo, C.; Escutnaire, J.; Wiel, E.; Dumont, C.; Castra, L.; Tazarourte, K.; El Khoury, C.; Gueugniaud, P.; Hubert, H.; and GR-RéAC\n\n\n \n\n\n\n The Journal of Emergency Medicine, 54(3): 295–301. 2018.\n \n\n\n\n
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@article{segal_evolution_2018,\n\ttitle = {Evolution of {Survival} in {Cardiac} {Arrest} with {Age} in {Elderly} {Patients}: {Is} {Resuscitation} a {Dead} {End}?},\n\tvolume = {54},\n\tissn = {0736-4679},\n\tshorttitle = {Evolution of {Survival} in {Cardiac} {Arrest} with {Age} in {Elderly} {Patients}},\n\tdoi = {10.1016/j.jemermed.2017.11.018},\n\tabstract = {BACKGROUND: Even if age is not considered the key prognostic factor for survival in cardiac arrest (CA), some studies question whether cardiopulmonary resuscitation (CPR) in the elderly could be futile.\nOBJECTIVE: The aim of this study was to describe differences in out-of-hospital CA survival rates according to age stratification based on the French National CA registry (RéAC). The second objective was to analyze the differences in resuscitation interventions according to age.\nMETHODS: We performed a retrospective cohort study based on data extracted from the RéAC. All 18,249 elderly patients ({\\textgreater}65 years old) with non-traumatic CA recorded between July 2011 and March 2015 were included. Patients' ages were stratified into 5-year increments.\nRESULTS: Cardiopulmonary resuscitation (CPR) was started significantly more often in younger patients (p = 0.019). Ventilation and automated external defibrillation by bystanders were started without any difference between age subgroups (p = 0.147 and p = 0.123, respectively). No difference in terms of rate of external chest compressions or ventilation initiation was found between the subgroups (p = 0.357 and p = 0.131, respectively). Advanced cardiac life support was started significantly more often in younger patients (p = 0.023). Total CPR duration, return of spontaneous circulation, and survival at hospital admission and at 30 days or hospital discharge decreased significantly with age (p {\\textless} 10-3). The survival decrease was linear, with a loss of 3\\% survival chances each 5-year interval.\nCONCLUSIONS: This study found that survival in older persons decreased linearly by 3\\% every 5 years. However, this diminished rate of survival could be the consequence of a shorter duration and less advanced life support.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {The Journal of Emergency Medicine},\n\tauthor = {Segal, Nicolas and di Pompéo, Christophe and Escutnaire, Joséphine and Wiel, Eric and Dumont, Cyrielle and Castra, Laurent and Tazarourte, Karim and El Khoury, Carlos and Gueugniaud, Pierre-Yves and Hubert, Hervé and {GR-RéAC}},\n\tyear = {2018},\n\tpmid = {29273461},\n\tkeywords = {Age Factors, Aged, Aged, 80 and over, Cohort Studies, Female, France, Humans, Linear Models, Male, Out-of-Hospital Cardiac Arrest, Registries, Resuscitation, Retrospective Studies, Survival Analysis, Time Factors, United States, aged, aged 80 and over, cardiac arrest, cardiopulmonary resuscitation, elderly, resuscitation},\n\tpages = {295--301},\n}\n\n
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\n BACKGROUND: Even if age is not considered the key prognostic factor for survival in cardiac arrest (CA), some studies question whether cardiopulmonary resuscitation (CPR) in the elderly could be futile. OBJECTIVE: The aim of this study was to describe differences in out-of-hospital CA survival rates according to age stratification based on the French National CA registry (RéAC). The second objective was to analyze the differences in resuscitation interventions according to age. METHODS: We performed a retrospective cohort study based on data extracted from the RéAC. All 18,249 elderly patients (\\textgreater65 years old) with non-traumatic CA recorded between July 2011 and March 2015 were included. Patients' ages were stratified into 5-year increments. RESULTS: Cardiopulmonary resuscitation (CPR) was started significantly more often in younger patients (p = 0.019). Ventilation and automated external defibrillation by bystanders were started without any difference between age subgroups (p = 0.147 and p = 0.123, respectively). No difference in terms of rate of external chest compressions or ventilation initiation was found between the subgroups (p = 0.357 and p = 0.131, respectively). Advanced cardiac life support was started significantly more often in younger patients (p = 0.023). Total CPR duration, return of spontaneous circulation, and survival at hospital admission and at 30 days or hospital discharge decreased significantly with age (p \\textless 10-3). The survival decrease was linear, with a loss of 3% survival chances each 5-year interval. CONCLUSIONS: This study found that survival in older persons decreased linearly by 3% every 5 years. However, this diminished rate of survival could be the consequence of a shorter duration and less advanced life support.\n
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\n \n\n \n \n \n \n \n Traumatic cardiac arrest is associated with lower survival rate vs. medical cardiac arrest - Results from the French national registry.\n \n \n \n\n\n \n Escutnaire, J.; Genin, M.; Babykina, E.; Dumont, C.; Javaudin, F.; Baert, V.; Mols, P.; Gräsner, J.; Wiel, E.; Gueugniaud, P.; Tazarourte, K.; Hubert, H.; and on behalf GR-RéAC\n\n\n \n\n\n\n Resuscitation, 131: 48–54. 2018.\n \n\n\n\n
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@article{escutnaire_traumatic_2018,\n\ttitle = {Traumatic cardiac arrest is associated with lower survival rate vs. medical cardiac arrest - {Results} from the {French} national registry},\n\tvolume = {131},\n\tissn = {1873-1570},\n\tdoi = {10.1016/j.resuscitation.2018.07.032},\n\tabstract = {INTRODUCTION: The survival from traumatic vs. medical out-of-hospital cardiac arrest (OHCA) are not yet well described. The objective of this study was to compare survival to hospital discharge and 30-day survival of non-matched and matched traumatic and medical OHCA cohorts.\nMATERIAL \\& METHODS: National case-control, multicentre study based on the French national cardiac arrest registry. Following descriptive analysis, we compared survival rates of traumatic and medical cardiac arrest patients after propensity score matching.\nRESULTS: Compared with medical OHCA (n = 40,878) trauma victims (n = 3209) were younger, more likely to be male and away from home at the time and less likely to be resuscitated. At hospital admission and at 30 days their survival odds were lower (OR: respectively 0.456 [0.353;0.558] and 0.240 [0.186;0.329]). After adjustment the survival odds for traumatic OHCA were 2.4 times lower at admission (OR: 0.416 [0.359;0.482]) and 6 times lower at day 30 (OR: 0.168 [0.117;0.241]).\nCONCLUSIONS: The survival rates for traumatic OHCA were lower than for medical OHCA, with wider difference in matched vs. non-matched cohorts. Although the probability of survival is lower for trauma victims, the efforts are not futile and pre-hospital resuscitation efforts seem worthwhile.},\n\tlanguage = {eng},\n\tjournal = {Resuscitation},\n\tauthor = {Escutnaire, Joséphine and Genin, Michael and Babykina, Evgéniya and Dumont, Cyrielle and Javaudin, François and Baert, Valentine and Mols, Pierre and Gräsner, Jan-Thorsten and Wiel, Eric and Gueugniaud, Pierre-Yves and Tazarourte, Karim and Hubert, Hervé and {on behalf GR-RéAC}},\n\tyear = {2018},\n\tpmid = {30059713},\n\tkeywords = {Adult, Age Distribution, Aged, Aged, 80 and over, Cardiopulmonary Resuscitation, Case-Control Studies, Cohort Studies, Emergency Medical Services, Female, France, Guidelines, Humans, Male, Middle Aged, Out-of-Hospital Cardiac Arrest, Outcome, Propensity Score, Propensity model, Registries, Resuscitation, Sex Distribution, Survival Rate, Traumatic cardiac arrest},\n\tpages = {48--54},\n}\n\n
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\n INTRODUCTION: The survival from traumatic vs. medical out-of-hospital cardiac arrest (OHCA) are not yet well described. The objective of this study was to compare survival to hospital discharge and 30-day survival of non-matched and matched traumatic and medical OHCA cohorts. MATERIAL & METHODS: National case-control, multicentre study based on the French national cardiac arrest registry. Following descriptive analysis, we compared survival rates of traumatic and medical cardiac arrest patients after propensity score matching. RESULTS: Compared with medical OHCA (n = 40,878) trauma victims (n = 3209) were younger, more likely to be male and away from home at the time and less likely to be resuscitated. At hospital admission and at 30 days their survival odds were lower (OR: respectively 0.456 [0.353;0.558] and 0.240 [0.186;0.329]). After adjustment the survival odds for traumatic OHCA were 2.4 times lower at admission (OR: 0.416 [0.359;0.482]) and 6 times lower at day 30 (OR: 0.168 [0.117;0.241]). CONCLUSIONS: The survival rates for traumatic OHCA were lower than for medical OHCA, with wider difference in matched vs. non-matched cohorts. Although the probability of survival is lower for trauma victims, the efforts are not futile and pre-hospital resuscitation efforts seem worthwhile.\n
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\n \n\n \n \n \n \n \n Can We Define Termination Of Resuscitation Criteria In Out-Of-Hospital Hanging?.\n \n \n \n\n\n \n Escutnaire, J.; Ducrocq, F.; Singier, A.; Baert, V.; Babykina, E.; Dumont, C.; Vilhelm, C.; Marc, J.; Segal, N.; Wiel, E.; Mols, P.; Hubert, H.; and GR-RéAC\n\n\n \n\n\n\n Prehospital emergency care: official journal of the National Association of EMS Physicians and the National Association of State EMS Directors,1–8. August 2018.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n  \n \n 68 downloads\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n
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@article{escutnaire_can_2018,\n\ttitle = {Can {We} {Define} {Termination} {Of} {Resuscitation} {Criteria} {In} {Out}-{Of}-{Hospital} {Hanging}?},\n\tissn = {1545-0066},\n\tdoi = {10.1080/10903127.2018.1476635},\n\tabstract = {OBJECTIVE: Survival rate of cardiac arrest due to hanging (H-CA) victims is low. Hence, this leads to the question of the utility of resuscitation in these patients. The objective was to investigate whether there are predictive criteria for survival with a good neurological outcome or predictive criteria for non-survival or survival with a poor neurological outcome enabling us to define the termination of resuscitation rules in these patients.\nMETHODS: Between July 1, 2011 and January 1, 2016, we included 1,689 out-of-hospital cardiac arrests due to hanging. We compared the characteristics of survivors with a good neurological outcome at day 30 with the others.\nRESULTS: The study population was mainly composed of males with a median age of 48 [37-60]. The overall survival was 2.1\\%, among which 48.6\\% had a good neurological outcome. Survivors benefited more often from immediate basic life support than the rest of the subjects, which was corroborated by the shorter no-flow durations. We did not record any difference in terms of advanced cardiac life support initiation frequency and technique between survivors with a good neurological outcome and the rest. Nevertheless, ACLS duration was longer in survivors with a good neurological outcome than in others.\nCONCLUSIONS: Basic life support (BLS) was the decisive criterion for 15/17 survivors. However, a detailed analysis showed 2 survivors presenting no BLS before the arrival of mobile medical teams and non-shockable rhythms who survived at day 30 with a good neurological outcome. These results lead us to consider that mobile medical team intervention and ACLS attempt are not futile, and the benefit justifies the cost. Thus, we cannot define any rule for the termination of resuscitation.},\n\tlanguage = {eng},\n\tjournal = {Prehospital emergency care: official journal of the National Association of EMS Physicians and the National Association of State EMS Directors},\n\tauthor = {Escutnaire, Joséphine and Ducrocq, François and Singier, Allison and Baert, Valentine and Babykina, Evgéniya and Dumont, Cyrielle and Vilhelm, Christian and Marc, Jean-Baptiste and Segal, Nicolas and Wiel, Eric and Mols, Pierre and Hubert, Hervé and {GR-RéAC}},\n\tmonth = aug,\n\tyear = {2018},\n\tpmid = {30118612},\n\tkeywords = {cardiac arrest, hanging, registry, survival, termination of resuscitation},\n\tpages = {1--8},\n}\n
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\n OBJECTIVE: Survival rate of cardiac arrest due to hanging (H-CA) victims is low. Hence, this leads to the question of the utility of resuscitation in these patients. The objective was to investigate whether there are predictive criteria for survival with a good neurological outcome or predictive criteria for non-survival or survival with a poor neurological outcome enabling us to define the termination of resuscitation rules in these patients. METHODS: Between July 1, 2011 and January 1, 2016, we included 1,689 out-of-hospital cardiac arrests due to hanging. We compared the characteristics of survivors with a good neurological outcome at day 30 with the others. RESULTS: The study population was mainly composed of males with a median age of 48 [37-60]. The overall survival was 2.1%, among which 48.6% had a good neurological outcome. Survivors benefited more often from immediate basic life support than the rest of the subjects, which was corroborated by the shorter no-flow durations. We did not record any difference in terms of advanced cardiac life support initiation frequency and technique between survivors with a good neurological outcome and the rest. Nevertheless, ACLS duration was longer in survivors with a good neurological outcome than in others. CONCLUSIONS: Basic life support (BLS) was the decisive criterion for 15/17 survivors. However, a detailed analysis showed 2 survivors presenting no BLS before the arrival of mobile medical teams and non-shockable rhythms who survived at day 30 with a good neurological outcome. These results lead us to consider that mobile medical team intervention and ACLS attempt are not futile, and the benefit justifies the cost. Thus, we cannot define any rule for the termination of resuscitation.\n
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\n  \n 2014\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n Joint latent class models for longitudinal and time-to-event data: a review.\n \n \n \n\n\n \n C Proust-Lima; M, S.; Taylor, J.; and Jacqmin-Gadda, H\n\n\n \n\n\n\n Stat Methods Med Res. 2014.\n \n\n\n\n
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@article{c_proust-lima_joint_2014,\n\tchapter = {23(1)},\n\ttitle = {Joint latent class models for longitudinal and time-to-event data: a review.},\n\tjournal = {Stat Methods Med Res},\n\tauthor = {{C Proust-Lima} and M, Séne and Taylor, JMG and Jacqmin-Gadda, H},\n\tyear = {2014},\n}\n\n
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