var bibbase_data = {"data":"<img src=\"//bibbase.org/img/ajax-loader.gif\" id=\"spinner\"\n  style=\"display: none;\" alt=\"Loading..\" />\n\n<div id=\"bibbase\">\n\n  <script type=\"text/javascript\">\n    var bibbase = {\n      params: {\"bib\":\"https://api.zotero.org/users/6607533/collections/EUK4Z2Y3/items?key=hGXLq241MCQA3ow7rlTIV2gY&format=bibtex&limit=100\",\"jsonp\":\"1\",\"host\":\"bibbase.org\"},\n      data: [{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"SMART for the treatment of asthma: A network meta-analysis of real-world evidence\",\"volume\":\"188\",\"issn\":\"09546111\",\"shorttitle\":\"SMART for the treatment of asthma\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X\",\"doi\":\"10.1016/j.rmed.2021.106611\",\"language\":\"en\",\"urldate\":\"2022-03-27\",\"journal\":\"Respiratory Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Rogliani\"],\"firstnames\":[\"Paola\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Cazzola\"],\"firstnames\":[\"Mario\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Calzetta\"],\"firstnames\":[\"Luigino\"],\"suffixes\":[]}],\"month\":\"November\",\"year\":\"2021\",\"pages\":\"106611\",\"bibtex\":\"@article{rogliani_smart_2021,\\n\\ttitle = {{SMART} for the treatment of asthma: {A} network meta-analysis of real-world evidence},\\n\\tvolume = {188},\\n\\tissn = {09546111},\\n\\tshorttitle = {{SMART} for the treatment of asthma},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X},\\n\\tdoi = {10.1016/j.rmed.2021.106611},\\n\\tlanguage = {en},\\n\\turldate = {2022-03-27},\\n\\tjournal = {Respiratory Medicine},\\n\\tauthor = {Rogliani, Paola and Beasley, Richard and Cazzola, Mario and Calzetta, Luigino},\\n\\tmonth = nov,\\n\\tyear = {2021},\\n\\tpages = {106611},\\n}\\n\\n\",\"author_short\":[\"Rogliani, P.\",\"Beasley, R.\",\"Cazzola, M.\",\"Calzetta, L.\"],\"key\":\"rogliani_smart_2021\",\"id\":\"rogliani_smart_2021\",\"bibbaseid\":\"rogliani-beasley-cazzola-calzetta-smartforthetreatmentofasthmaanetworkmetaanalysisofrealworldevidence-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Enhanced airway sensory nerve reactivity in non-eosinophilic asthma\",\"volume\":\"8\",\"issn\":\"2052-4439\",\"url\":\"https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974\",\"doi\":\"10.1136/bmjresp-2021-000974\",\"abstract\":\"Background Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics. Methods Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5%. Airway hyperreactivity was defined as a ≥15% drop in FEV 1 during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs. Results Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p\\\\textless0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV 1 was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed. Conclusion NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2022-03-27\",\"journal\":\"BMJ Open Respiratory Research\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Ali\"],\"firstnames\":[\"Hajar\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Brooks\"],\"firstnames\":[\"Collin\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Crane\"],\"firstnames\":[\"Julian\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holgate\"],\"firstnames\":[\"Stephen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gibson\"],\"firstnames\":[\"Peter\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pattemore\"],\"firstnames\":[\"Philip\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tzeng\"],\"firstnames\":[\"Yu-Chieh\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Stanley\"],\"firstnames\":[\"Thorsten\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pearce\"],\"firstnames\":[\"Neil\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Douwes\"],\"firstnames\":[\"Jeroen\"],\"suffixes\":[]}],\"month\":\"November\",\"year\":\"2021\",\"pages\":\"e000974\",\"bibtex\":\"@article{ali_enhanced_2021,\\n\\ttitle = {Enhanced airway sensory nerve reactivity in non-eosinophilic asthma},\\n\\tvolume = {8},\\n\\tissn = {2052-4439},\\n\\turl = {https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974},\\n\\tdoi = {10.1136/bmjresp-2021-000974},\\n\\tabstract = {Background\\n              Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics.\\n            \\n            \\n              Methods\\n              \\n                Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5\\\\%. Airway hyperreactivity was defined as a ≥15\\\\% drop in FEV\\n                1\\n                during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs.\\n              \\n            \\n            \\n              Results\\n              \\n                Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95\\\\% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p{\\\\textless}0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV\\n                1\\n                was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed.\\n              \\n            \\n            \\n              Conclusion\\n              NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2022-03-27},\\n\\tjournal = {BMJ Open Respiratory Research},\\n\\tauthor = {Ali, Hajar and Brooks, Collin and Crane, Julian and Beasley, Richard and Holgate, Stephen and Gibson, Peter and Pattemore, Philip and Tzeng, Yu-Chieh and Stanley, Thorsten and Pearce, Neil and Douwes, Jeroen},\\n\\tmonth = nov,\\n\\tyear = {2021},\\n\\tpages = {e000974},\\n}\\n\\n\",\"author_short\":[\"Ali, H.\",\"Brooks, C.\",\"Crane, J.\",\"Beasley, R.\",\"Holgate, S.\",\"Gibson, P.\",\"Pattemore, P.\",\"Tzeng, Y.\",\"Stanley, T.\",\"Pearce, N.\",\"Douwes, J.\"],\"key\":\"ali_enhanced_2021\",\"id\":\"ali_enhanced_2021\",\"bibbaseid\":\"ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Asthma in the anti-inflammatory reliever therapy era\",\"volume\":\"9\",\"issn\":\"22132600\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653\",\"doi\":\"10.1016/S2213-2600(20)30465-3\",\"language\":\"en\",\"number\":\"2\",\"urldate\":\"2022-03-27\",\"journal\":\"The Lancet Respiratory Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Baggott\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"February\",\"year\":\"2021\",\"pages\":\"118–119\",\"bibtex\":\"@article{baggott_asthma_2021,\\n\\ttitle = {Asthma in the anti-inflammatory reliever therapy era},\\n\\tvolume = {9},\\n\\tissn = {22132600},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653},\\n\\tdoi = {10.1016/S2213-2600(20)30465-3},\\n\\tlanguage = {en},\\n\\tnumber = {2},\\n\\turldate = {2022-03-27},\\n\\tjournal = {The Lancet Respiratory Medicine},\\n\\tauthor = {Baggott, Christina and Beasley, Richard},\\n\\tmonth = feb,\\n\\tyear = {2021},\\n\\tpages = {118--119},\\n}\\n\\n\",\"author_short\":[\"Baggott, C.\",\"Beasley, R.\"],\"key\":\"baggott_asthma_2021\",\"id\":\"baggott_asthma_2021\",\"bibbaseid\":\"baggott-beasley-asthmaintheantiinflammatoryrelievertherapyera-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study\",\"volume\":\"12\",\"issn\":\"2044-6055, 2044-6055\",\"shorttitle\":\"Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens\",\"url\":\"https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537\",\"doi\":\"10.1136/bmjopen-2020-048537\",\"abstract\":\"Objectives As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens. Setting A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment. Participants Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings. Results Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it. Conclusions Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation. Trial registration number ACTRN12615000999538.\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2022-03-27\",\"journal\":\"BMJ Open\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Foster\"],\"firstnames\":[\"Juliet\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harrison\"],\"firstnames\":[\"Tim\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2022\",\"pages\":\"e048537\",\"bibtex\":\"@article{foster_perspectives_2022,\\n\\ttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study},\\n\\tvolume = {12},\\n\\tissn = {2044-6055, 2044-6055},\\n\\tshorttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens},\\n\\turl = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537},\\n\\tdoi = {10.1136/bmjopen-2020-048537},\\n\\tabstract = {Objectives\\n              As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens.\\n            \\n            \\n              Setting\\n              A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment.\\n            \\n            \\n              Participants\\n              Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings.\\n            \\n            \\n              Results\\n              Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it.\\n            \\n            \\n              Conclusions\\n              Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation.\\n            \\n            \\n              Trial registration number\\n              ACTRN12615000999538.},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2022-03-27},\\n\\tjournal = {BMJ Open},\\n\\tauthor = {Foster, Juliet and Beasley, Richard and Braithwaite, Irene and Harrison, Tim and Holliday, Mark and Pavord, Ian and Reddel, Helen},\\n\\tmonth = jan,\\n\\tyear = {2022},\\n\\tpages = {e048537},\\n}\\n\\n\",\"author_short\":[\"Foster, J.\",\"Beasley, R.\",\"Braithwaite, I.\",\"Harrison, T.\",\"Holliday, M.\",\"Pavord, I.\",\"Reddel, H.\"],\"key\":\"foster_perspectives_2022\",\"id\":\"foster_perspectives_2022\",\"bibbaseid\":\"foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype Oxford Asthma Attack Risk Scale (ORACLE)\",\"volume\":\"8\",\"issn\":\"2312-0541\",\"url\":\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021\",\"doi\":\"10.1183/23120541.00570-2021\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2022-03-27\",\"journal\":\"ERJ Open Research\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Couillard\"],\"firstnames\":[\"Simon\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Do\"],\"firstnames\":[\"William\",\"Il\",\"Hoon\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hinks\"],\"firstnames\":[\"Timothy\",\"S.C.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\",\"D.\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2022\",\"pages\":\"00570–2021\",\"bibtex\":\"@article{couillard_predicting_2022,\\n\\ttitle = {Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype {Oxford} {Asthma} {Attack} {Risk} {Scale} ({ORACLE})},\\n\\tvolume = {8},\\n\\tissn = {2312-0541},\\n\\turl = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021},\\n\\tdoi = {10.1183/23120541.00570-2021},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2022-03-27},\\n\\tjournal = {ERJ Open Research},\\n\\tauthor = {Couillard, Simon and Do, William Il Hoon and Beasley, Richard and Hinks, Timothy S.C. and Pavord, Ian D.},\\n\\tmonth = jan,\\n\\tyear = {2022},\\n\\tpages = {00570--2021},\\n}\\n\\n\",\"author_short\":[\"Couillard, S.\",\"Do, W. I. H.\",\"Beasley, R.\",\"Hinks, T. S.\",\"Pavord, I. D.\"],\"key\":\"couillard_predicting_2022\",\"id\":\"couillard_predicting_2022\",\"bibbaseid\":\"couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma: A Systematic Review and Meta-analysis\",\"volume\":\"5\",\"issn\":\"2574-3805\",\"shorttitle\":\"Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma\",\"url\":\"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512\",\"doi\":\"10.1001/jamanetworkopen.2022.0615\",\"language\":\"en\",\"number\":\"3\",\"urldate\":\"2022-03-04\",\"journal\":\"JAMA Network Open\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harrison\"],\"firstnames\":[\"Tim\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Peterson\"],\"firstnames\":[\"Stefan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gustafson\"],\"firstnames\":[\"Per\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hamblin\"],\"firstnames\":[\"Angus\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bengtsson\"],\"firstnames\":[\"Thomas\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fagerås\"],\"firstnames\":[\"Malin\"],\"suffixes\":[]}],\"month\":\"March\",\"year\":\"2022\",\"pages\":\"e220615\",\"bibtex\":\"@article{beasley_evaluation_2022,\\n\\ttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}: {A} {Systematic} {Review} and {Meta}-analysis},\\n\\tvolume = {5},\\n\\tissn = {2574-3805},\\n\\tshorttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}},\\n\\turl = {https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512},\\n\\tdoi = {10.1001/jamanetworkopen.2022.0615},\\n\\tlanguage = {en},\\n\\tnumber = {3},\\n\\turldate = {2022-03-04},\\n\\tjournal = {JAMA Network Open},\\n\\tauthor = {Beasley, Richard and Harrison, Tim and Peterson, Stefan and Gustafson, Per and Hamblin, Angus and Bengtsson, Thomas and Fagerås, Malin},\\n\\tmonth = mar,\\n\\tyear = {2022},\\n\\tpages = {e220615},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Harrison, T.\",\"Peterson, S.\",\"Gustafson, P.\",\"Hamblin, A.\",\"Bengtsson, T.\",\"Fagerås, M.\"],\"key\":\"beasley_evaluation_2022\",\"id\":\"beasley_evaluation_2022\",\"bibbaseid\":\"beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Asthma and COVID-19: Preconceptions about Predisposition\",\"volume\":\"203\",\"issn\":\"1073-449X, 1535-4970\",\"shorttitle\":\"Asthma and COVID-19\",\"url\":\"https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED\",\"doi\":\"10.1164/rccm.202102-0266ED\",\"language\":\"en\",\"number\":\"7\",\"urldate\":\"2022-03-04\",\"journal\":\"American Journal of Respiratory and Critical Care Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hills\"],\"firstnames\":[\"Thomas\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kearns\"],\"firstnames\":[\"Nethmi\"],\"suffixes\":[]}],\"month\":\"April\",\"year\":\"2021\",\"pages\":\"799–801\",\"bibtex\":\"@article{beasley_asthma_2021,\\n\\ttitle = {Asthma and {COVID}-19: {Preconceptions} about {Predisposition}},\\n\\tvolume = {203},\\n\\tissn = {1073-449X, 1535-4970},\\n\\tshorttitle = {Asthma and {COVID}-19},\\n\\turl = {https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED},\\n\\tdoi = {10.1164/rccm.202102-0266ED},\\n\\tlanguage = {en},\\n\\tnumber = {7},\\n\\turldate = {2022-03-04},\\n\\tjournal = {American Journal of Respiratory and Critical Care Medicine},\\n\\tauthor = {Beasley, Richard and Hills, Thomas and Kearns, Nethmi},\\n\\tmonth = apr,\\n\\tyear = {2021},\\n\\tpages = {799--801},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Hills, T.\",\"Kearns, N.\"],\"key\":\"beasley_asthma_2021\",\"id\":\"beasley_asthma_2021\",\"bibbaseid\":\"beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":2,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: A randomised cross-over trial\",\"issn\":\"0903-1936, 1399-3003\",\"shorttitle\":\"Repeated dose budesonide/formoterol compared to salbutamol in adult asthma\",\"url\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021\",\"doi\":\"10.1183/13993003.02309-2021\",\"abstract\":\"Objective To determine the comparative bronchodilator, systemic beta 2 -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma. Methods This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg via MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg via nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation via Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV 1 after 180 min. Secondary outcomes included repeat measures of FEV 1 , serum potassium, heart rate, and adverse events Results Of 39 patients randomised, two withdrew due to adverse events (QT CF prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean ( sd ) change from baseline FEV 1 180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean ( sd ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV 1 from 30 to 240 min, but lesser FEV 1 at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events. Conclusion The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose −1 and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta 2 -agonist and cardiovascular effects and more adverse events.\",\"language\":\"en\",\"urldate\":\"2022-03-04\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Kearns\"],\"firstnames\":[\"Nethmi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bruce\"],\"firstnames\":[\"Pepa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Doppen\"],\"firstnames\":[\"Marjan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Black\"],\"firstnames\":[\"Melissa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"February\",\"year\":\"2022\",\"pages\":\"2102309\",\"bibtex\":\"@article{kearns_repeated_2022,\\n\\ttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: {A} randomised cross-over trial},\\n\\tissn = {0903-1936, 1399-3003},\\n\\tshorttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma},\\n\\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021},\\n\\tdoi = {10.1183/13993003.02309-2021},\\n\\tabstract = {Objective\\n              \\n                To determine the comparative bronchodilator, systemic beta\\n                2\\n                -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma.\\n              \\n            \\n            \\n              Methods\\n              \\n                This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg\\n                via\\n                MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg\\n                via\\n                nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation\\n                via\\n                Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV\\n                1\\n                after 180 min. Secondary outcomes included repeat measures of FEV\\n                1\\n                , serum potassium, heart rate, and adverse events\\n              \\n            \\n            \\n              Results\\n              \\n                Of 39 patients randomised, two withdrew due to adverse events (QT\\n                CF\\n                prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean (\\n                sd\\n                ) change from baseline FEV\\n                1\\n                180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean (\\n                sd\\n                ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95\\\\% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV\\n                1\\n                from 30 to 240 min, but lesser FEV\\n                1\\n                at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events.\\n              \\n            \\n            \\n              Conclusion\\n              \\n                The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose\\n                −1\\n                and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta\\n                2\\n                -agonist and cardiovascular effects and more adverse events.},\\n\\tlanguage = {en},\\n\\turldate = {2022-03-04},\\n\\tjournal = {European Respiratory Journal},\\n\\tauthor = {Kearns, Nethmi and Bruce, Pepa and Williams, Mathew and Doppen, Marjan and Black, Melissa and Weatherall, Mark and Beasley, Richard},\\n\\tmonth = feb,\\n\\tyear = {2022},\\n\\tpages = {2102309},\\n}\\n\\n\",\"author_short\":[\"Kearns, N.\",\"Bruce, P.\",\"Williams, M.\",\"Doppen, M.\",\"Black, M.\",\"Weatherall, M.\",\"Beasley, R.\"],\"key\":\"kearns_repeated_2022\",\"id\":\"kearns_repeated_2022\",\"bibbaseid\":\"kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Respiratory syncytial virus: paying the immunity debt with interest\",\"issn\":\"23524642\",\"shorttitle\":\"Respiratory syncytial virus\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333\",\"doi\":\"10.1016/S2352-4642(21)00333-3\",\"language\":\"en\",\"urldate\":\"2021-10-28\",\"journal\":\"The Lancet Child & Adolescent Health\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Hatter\"],\"firstnames\":[\"Lee\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Eathorne\"],\"firstnames\":[\"Allie\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hills\"],\"firstnames\":[\"Thomas\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bruce\"],\"firstnames\":[\"Pepa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"October\",\"year\":\"2021\",\"pages\":\"S2352464221003333\",\"bibtex\":\"@article{hatter_respiratory_2021,\\n\\ttitle = {Respiratory syncytial virus: paying the immunity debt with interest},\\n\\tissn = {23524642},\\n\\tshorttitle = {Respiratory syncytial virus},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333},\\n\\tdoi = {10.1016/S2352-4642(21)00333-3},\\n\\tlanguage = {en},\\n\\turldate = {2021-10-28},\\n\\tjournal = {The Lancet Child \\\\& Adolescent Health},\\n\\tauthor = {Hatter, Lee and Eathorne, Allie and Hills, Thomas and Bruce, Pepa and Beasley, Richard},\\n\\tmonth = oct,\\n\\tyear = {2021},\\n\\tpages = {S2352464221003333},\\n}\\n\\n\",\"author_short\":[\"Hatter, L.\",\"Eathorne, A.\",\"Hills, T.\",\"Bruce, P.\",\"Beasley, R.\"],\"key\":\"hatter_respiratory_2021\",\"id\":\"hatter_respiratory_2021\",\"bibbaseid\":\"hatter-eathorne-hills-bruce-beasley-respiratorysyncytialviruspayingtheimmunitydebtwithinterest-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Patient experiences of as-needed budesonide-formoterol by Turbuhaler® for treatment of mild asthma; a qualitative study\",\"volume\":\"175\",\"issn\":\"09546111\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948\",\"doi\":\"10.1016/j.rmed.2020.106154\",\"language\":\"en\",\"urldate\":\"2021-05-12\",\"journal\":\"Respiratory Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Foster\"],\"firstnames\":[\"J.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"I.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harrison\"],\"firstnames\":[\"T.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"I.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"H.K.\"],\"suffixes\":[]}],\"month\":\"December\",\"year\":\"2020\",\"pages\":\"106154\",\"bibtex\":\"@article{foster_patient_2020,\\n\\ttitle = {Patient experiences of as-needed budesonide-formoterol by {Turbuhaler}® for treatment of mild asthma; a qualitative study},\\n\\tvolume = {175},\\n\\tissn = {09546111},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948},\\n\\tdoi = {10.1016/j.rmed.2020.106154},\\n\\tlanguage = {en},\\n\\turldate = {2021-05-12},\\n\\tjournal = {Respiratory Medicine},\\n\\tauthor = {Foster, J.M. and Beasley, R. and Braithwaite, I. and Harrison, T. and Holliday, M. and Pavord, I. and Reddel, H.K.},\\n\\tmonth = dec,\\n\\tyear = {2020},\\n\\tpages = {106154},\\n}\\n\\n\",\"author_short\":[\"Foster, J.\",\"Beasley, R.\",\"Braithwaite, I.\",\"Harrison, T.\",\"Holliday, M.\",\"Pavord, I.\",\"Reddel, H.\"],\"key\":\"foster_patient_2020\",\"id\":\"foster_patient_2020\",\"bibbaseid\":\"foster-beasley-braithwaite-harrison-holliday-pavord-reddel-patientexperiencesofasneededbudesonideformoterolbyturbuhalerfortreatmentofmildasthmaaqualitativestudy-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Anti-interleukin-5 therapy in patients with severe asthma: from clinical trials to clinical practice\",\"volume\":\"8\",\"issn\":\"22132600\",\"shorttitle\":\"Anti-interleukin-5 therapy in patients with severe asthma\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515\",\"doi\":\"10.1016/S2213-2600(20)30051-5\",\"language\":\"en\",\"number\":\"5\",\"urldate\":\"2021-05-07\",\"journal\":\"The Lancet Respiratory Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harper\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Masoli\"],\"firstnames\":[\"Matthew\"],\"suffixes\":[]}],\"month\":\"May\",\"year\":\"2020\",\"pages\":\"425–427\",\"bibtex\":\"@article{beasley_anti-interleukin-5_2020,\\n\\ttitle = {Anti-interleukin-5 therapy in patients with severe asthma: from clinical trials to clinical practice},\\n\\tvolume = {8},\\n\\tissn = {22132600},\\n\\tshorttitle = {Anti-interleukin-5 therapy in patients with severe asthma},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515},\\n\\tdoi = {10.1016/S2213-2600(20)30051-5},\\n\\tlanguage = {en},\\n\\tnumber = {5},\\n\\turldate = {2021-05-07},\\n\\tjournal = {The Lancet Respiratory Medicine},\\n\\tauthor = {Beasley, Richard and Harper, James and Masoli, Matthew},\\n\\tmonth = may,\\n\\tyear = {2020},\\n\\tpages = {425--427},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Harper, J.\",\"Masoli, M.\"],\"key\":\"beasley_anti-interleukin-5_2020\",\"id\":\"beasley_anti-interleukin-5_2020\",\"bibbaseid\":\"beasley-harper-masoli-antiinterleukin5therapyinpatientswithsevereasthmafromclinicaltrialstoclinicalpractice-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Twenty‐five years of Respirology: Advances in asthma\",\"volume\":\"25\",\"issn\":\"1323-7799, 1440-1843\",\"shorttitle\":\"Twenty‐five years of <i>Respirology</i>\",\"url\":\"https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735\",\"doi\":\"10.1111/resp.13735\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2021-05-07\",\"journal\":\"Respirology\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gibson\"],\"firstnames\":[\"Peter\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2020\",\"pages\":\"11–13\",\"bibtex\":\"@article{beasley_twentyfive_2020,\\n\\ttitle = {Twenty‐five years of {Respirology}: {Advances} in asthma},\\n\\tvolume = {25},\\n\\tissn = {1323-7799, 1440-1843},\\n\\tshorttitle = {Twenty‐five years of \\\\textit{{Respirology}}},\\n\\turl = {https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735},\\n\\tdoi = {10.1111/resp.13735},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2021-05-07},\\n\\tjournal = {Respirology},\\n\\tauthor = {Beasley, Richard and Gibson, Peter},\\n\\tmonth = jan,\\n\\tyear = {2020},\\n\\tpages = {11--13},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Gibson, P.\"],\"key\":\"beasley_twentyfive_2020\",\"id\":\"beasley_twentyfive_2020\",\"bibbaseid\":\"beasley-gibson-twentyfiveyearsofrespirologyadvancesinasthma-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"ICS-formoterol reliever therapy stepwise treatment algorithm for adult asthma\",\"volume\":\"55\",\"issn\":\"0903-1936, 1399-3003\",\"url\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019\",\"doi\":\"10.1183/13993003.01407-2019\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2021-05-07\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Semprini\"],\"firstnames\":[\"Alex\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kearns\"],\"firstnames\":[\"Ciléin\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harrison\"],\"firstnames\":[\"Tim\",\"W.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Papi\"],\"firstnames\":[\"Alberto\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\",\"D.\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2020\",\"pages\":\"1901407\",\"bibtex\":\"@article{beasley_ics-formoterol_2020,\\n\\ttitle = {{ICS}-formoterol reliever therapy stepwise treatment algorithm for adult asthma},\\n\\tvolume = {55},\\n\\tissn = {0903-1936, 1399-3003},\\n\\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019},\\n\\tdoi = {10.1183/13993003.01407-2019},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2021-05-07},\\n\\tjournal = {European Respiratory Journal},\\n\\tauthor = {Beasley, Richard and Braithwaite, Irene and Semprini, Alex and Kearns, Ciléin and Weatherall, Mark and Harrison, Tim W. and Papi, Alberto and Pavord, Ian D.},\\n\\tmonth = jan,\\n\\tyear = {2020},\\n\\tpages = {1901407},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Braithwaite, I.\",\"Semprini, A.\",\"Kearns, C.\",\"Weatherall, M.\",\"Harrison, T. W.\",\"Papi, A.\",\"Pavord, I. D.\"],\"key\":\"beasley_ics-formoterol_2020\",\"id\":\"beasley_ics-formoterol_2020\",\"bibbaseid\":\"beasley-braithwaite-semprini-kearns-weatherall-harrison-papi-pavord-icsformoterolrelievertherapystepwisetreatmentalgorithmforadultasthma-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma: findings from the PRACTICAL study, a randomised clinical trial\",\"volume\":\"55\",\"issn\":\"0903-1936, 1399-3003\",\"shorttitle\":\"Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma\",\"url\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019\",\"doi\":\"10.1183/13993003.02073-2019\",\"abstract\":\"Symptom-driven low-dose inhaled corticosteroid–formoterol is safe and effective in mild asthma and has been recommended as one of the preferred treatment regimens at steps 1 and 2 in the 2019 update of the Global Initiative for Asthma. However, there are no data on patient preferences for this regimen. A subgroup of participants in the PRACTICAL study (ACTRN12616000377437), a randomised controlled trial comparing symptom-driven budesonide–formoterol with maintenance budesonide plus as-needed terbutaline completed a survey on treatment preferences, satisfaction, beliefs and experience at their final study visit. 306 (75%) out of 407 eligible participants completed the survey. Regimen preference was strongly associated with randomised treatment, as were preferences for and beliefs about preventer inhaler use. Combination preventer and reliever as-needed therapy was preferred by 135 (90%, 95% CI 85.2–94.8%) out of 150 who were randomised to as-needed budesonide–formoterol, and by 63 (40%, 95% CI 32.7–48.1%) out of 156 who were randomised to maintenance budesonide. By contrast, twice-daily preventer inhaler with a reliever inhaler as required was preferred by 15 (10%) out of 150 of those randomised to as-needed budesonide–formoterol and 93 (60%) out of 156 of those randomised to maintenance budesonide. Satisfaction with all study inhalers was high. Of patients randomised to as-needed budesonide–formoterol 92% (n=138) were confident using it as a reliever at the end of the study. Although most participants preferred the regimen to which they had been randomised, this association was much stronger for those randomised to budesonide–formoterol as needed, indicating that most patients preferred as-needed corticosteroid–formoterol therapy if they had experienced it.\",\"language\":\"en\",\"number\":\"4\",\"urldate\":\"2021-05-07\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Baggott\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hardy\"],\"firstnames\":[\"Jo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sparks\"],\"firstnames\":[\"Jenny\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Corin\"],\"firstnames\":[\"Andrew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Montgomery\"],\"firstnames\":[\"Barney\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reid\"],\"firstnames\":[\"Jim\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sheahan\"],\"firstnames\":[\"Davitt\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]}],\"month\":\"April\",\"year\":\"2020\",\"pages\":\"1902073\",\"bibtex\":\"@article{baggott_patient_2020,\\n\\ttitle = {Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma: findings from the {PRACTICAL} study, a randomised clinical trial},\\n\\tvolume = {55},\\n\\tissn = {0903-1936, 1399-3003},\\n\\tshorttitle = {Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma},\\n\\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019},\\n\\tdoi = {10.1183/13993003.02073-2019},\\n\\tabstract = {Symptom-driven low-dose inhaled corticosteroid–formoterol is safe and effective in mild asthma and has been recommended as one of the preferred treatment regimens at steps 1 and 2 in the 2019 update of the Global Initiative for Asthma. However, there are no data on patient preferences for this regimen.\\n            A subgroup of participants in the PRACTICAL study (ACTRN12616000377437), a randomised controlled trial comparing symptom-driven budesonide–formoterol with maintenance budesonide plus as-needed terbutaline completed a survey on treatment preferences, satisfaction, beliefs and experience at their final study visit.\\n            306 (75\\\\%) out of 407 eligible participants completed the survey. Regimen preference was strongly associated with randomised treatment, as were preferences for and beliefs about preventer inhaler use. Combination preventer and reliever as-needed therapy was preferred by 135 (90\\\\%, 95\\\\% CI 85.2–94.8\\\\%) out of 150 who were randomised to as-needed budesonide–formoterol, and by 63 (40\\\\%, 95\\\\% CI 32.7–48.1\\\\%) out of 156 who were randomised to maintenance budesonide. By contrast, twice-daily preventer inhaler with a reliever inhaler as required was preferred by 15 (10\\\\%) out of 150 of those randomised to as-needed budesonide–formoterol and 93 (60\\\\%) out of 156 of those randomised to maintenance budesonide. Satisfaction with all study inhalers was high. Of patients randomised to as-needed budesonide–formoterol 92\\\\% (n=138) were confident using it as a reliever at the end of the study.\\n            Although most participants preferred the regimen to which they had been randomised, this association was much stronger for those randomised to budesonide–formoterol as needed, indicating that most patients preferred as-needed corticosteroid–formoterol therapy if they had experienced it.},\\n\\tlanguage = {en},\\n\\tnumber = {4},\\n\\turldate = {2021-05-07},\\n\\tjournal = {European Respiratory Journal},\\n\\tauthor = {Baggott, Christina and Reddel, Helen K. and Hardy, Jo and Sparks, Jenny and Holliday, Mark and Corin, Andrew and Montgomery, Barney and Reid, Jim and Sheahan, Davitt and Hancox, Robert J. and Weatherall, Mark and Beasley, Richard and Fingleton, James},\\n\\tmonth = apr,\\n\\tyear = {2020},\\n\\tpages = {1902073},\\n}\\n\\n\",\"author_short\":[\"Baggott, C.\",\"Reddel, H. K.\",\"Hardy, J.\",\"Sparks, J.\",\"Holliday, M.\",\"Corin, A.\",\"Montgomery, B.\",\"Reid, J.\",\"Sheahan, D.\",\"Hancox, R. J.\",\"Weatherall, M.\",\"Beasley, R.\",\"Fingleton, J.\"],\"key\":\"baggott_patient_2020\",\"id\":\"baggott_patient_2020\",\"bibbaseid\":\"baggott-reddel-hardy-sparks-holliday-corin-montgomery-reid-etal-patientpreferencesforsymptomdrivenorregularpreventertreatmentinmildtomoderateasthmafindingsfromthepracticalstudyarandomisedclinicaltrial-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"What matters most to patients when choosing treatment for mild–moderate asthma? Results from a discrete choice experiment\",\"volume\":\"75\",\"issn\":\"0040-6376, 1468-3296\",\"shorttitle\":\"What matters most to patients when choosing treatment for mild–moderate asthma?\",\"url\":\"https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343\",\"doi\":\"10.1136/thoraxjnl-2019-214343\",\"abstract\":\"Background An as-needed combination preventer and reliever regimen was recently introduced as an alternative to conventional daily preventer treatment for mild asthma. In a subgroup analysis of the PRACTICAL study, a pragmatic randomised controlled trial of budesonide–formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild asthma, we recently reported that about two-thirds preferred as-needed combination preventer and reliever therapy. The aim of this study was to determine the relative importance of attributes associated with these two asthma therapies in this subgroup of participants who indicated their preferred treatment in the PRACTICAL study. Methods At their final study visit, a subgroup of participants indicated their preferred treatment and completed a discrete choice experiment using the Potentially All Pairwise RanKings of all possible Alternatives method and 1000minds software. Treatment attributes and their levels were selected from measurable study outcomes, and included: treatment regimen, shortness of breath, steroid dose and likelihood of asthma flare-up. Results The final analysis dataset included 288 participants, 64% of whom preferred as-needed combination preventer and reliever. Of the attributes, no shortness of breath and lowest risk of asthma flare-up were ranked highest and second highest, respectively. However, the relative importance of the other two attributes varied by preferred therapy: treatment regimen was ranked higher by participants who preferred as-needed treatment than by participants who preferred maintenance treatment. Conclusions Knowledge of patient preferences for treatment attributes together with regimen characteristics can be used in shared decision-making regarding choice of treatment for patients with mild–moderate asthma. Trial registration number ACTRN12616000377437.\",\"language\":\"en\",\"number\":\"10\",\"urldate\":\"2021-05-05\",\"journal\":\"Thorax\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Baggott\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hansen\"],\"firstnames\":[\"Paul\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hardy\"],\"firstnames\":[\"Jo\",\"Katherine\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sparks\"],\"firstnames\":[\"Jenny\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]}],\"month\":\"October\",\"year\":\"2020\",\"pages\":\"842–848\",\"bibtex\":\"@article{baggott_what_2020,\\n\\ttitle = {What matters most to patients when choosing treatment for mild–moderate asthma? {Results} from a discrete choice experiment},\\n\\tvolume = {75},\\n\\tissn = {0040-6376, 1468-3296},\\n\\tshorttitle = {What matters most to patients when choosing treatment for mild–moderate asthma?},\\n\\turl = {https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343},\\n\\tdoi = {10.1136/thoraxjnl-2019-214343},\\n\\tabstract = {Background\\n              An as-needed combination preventer and reliever regimen was recently introduced as an alternative to conventional daily preventer treatment for mild asthma. In a subgroup analysis of the PRACTICAL study, a pragmatic randomised controlled trial of budesonide–formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild asthma, we recently reported that about two-thirds preferred as-needed combination preventer and reliever therapy. The aim of this study was to determine the relative importance of attributes associated with these two asthma therapies in this subgroup of participants who indicated their preferred treatment in the PRACTICAL study.\\n            \\n            \\n              Methods\\n              At their final study visit, a subgroup of participants indicated their preferred treatment and completed a discrete choice experiment using the Potentially All Pairwise RanKings of all possible Alternatives method and 1000minds software. Treatment attributes and their levels were selected from measurable study outcomes, and included: treatment regimen, shortness of breath, steroid dose and likelihood of asthma flare-up.\\n            \\n            \\n              Results\\n              The final analysis dataset included 288 participants, 64\\\\% of whom preferred as-needed combination preventer and reliever. Of the attributes, no shortness of breath and lowest risk of asthma flare-up were ranked highest and second highest, respectively. However, the relative importance of the other two attributes varied by preferred therapy: treatment regimen was ranked higher by participants who preferred as-needed treatment than by participants who preferred maintenance treatment.\\n            \\n            \\n              Conclusions\\n              Knowledge of patient preferences for treatment attributes together with regimen characteristics can be used in shared decision-making regarding choice of treatment for patients with mild–moderate asthma.\\n            \\n            \\n              Trial registration number\\n              ACTRN12616000377437.},\\n\\tlanguage = {en},\\n\\tnumber = {10},\\n\\turldate = {2021-05-05},\\n\\tjournal = {Thorax},\\n\\tauthor = {Baggott, Christina and Hansen, Paul and Hancox, Robert J and Hardy, Jo Katherine and Sparks, Jenny and Holliday, Mark and Weatherall, Mark and Beasley, Richard and Reddel, Helen K and Fingleton, James},\\n\\tmonth = oct,\\n\\tyear = {2020},\\n\\tpages = {842--848},\\n}\\n\\n\",\"author_short\":[\"Baggott, C.\",\"Hansen, P.\",\"Hancox, R. J\",\"Hardy, J. K.\",\"Sparks, J.\",\"Holliday, M.\",\"Weatherall, M.\",\"Beasley, R.\",\"Reddel, H. K\",\"Fingleton, J.\"],\"key\":\"baggott_what_2020\",\"id\":\"baggott_what_2020\",\"bibbaseid\":\"baggott-hansen-hancox-hardy-sparks-holliday-weatherall-beasley-etal-whatmattersmosttopatientswhenchoosingtreatmentformildmoderateasthmaresultsfromadiscretechoiceexperiment-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Combination budesonide/formoterol inhaler as sole reliever therapy in Māori and Pacific people with mild and moderate asthma\",\"volume\":\"133\",\"issn\":\"1175-8716\",\"abstract\":\"AIM: In the PRACTICAL study, as-needed budesonide/formoterol reduced the rate of severe exacerbations compared with maintenance budesonide plus as-needed terbutaline. In a pre-specified analysis we analysed the efficacy in Māori and Pacific peoples, populations with worse asthma outcomes. METHOD: The PRACTICAL study was a 52-week, open-label, parallel group, randomised controlled trial of 890 adults with mild to moderate asthma, who were randomised to budesonide/formoterol Turbuhaler 200/6mcg one actuation as required or budesonide Turbuhaler 200mcg one actuation twice daily and terbutaline Turbuhaler 250mcg two actuations as required. The primary outcome was rate of severe exacerbations. The analysis strategy was to test an ethnicity-treatment interaction term for each outcome variable. RESULTS: Seventy-two participants (8%) identified as Māori, 36 participants (4%) as Pacific ethnicity. There was no evidence that ethnicity was an effect modifier for severe exacerbations (P interaction 0.70). CONCLUSION: The reduction in severe exacerbation risk with budesonide-formoterol reliever compared with maintenance budesonide was similar in Māori and Pacific adults compared with New Zealand European/Other.\",\"language\":\"eng\",\"number\":\"1520\",\"journal\":\"The New Zealand Medical Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Hardy\"],\"firstnames\":[\"Jo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tewhaiti-Smith\"],\"firstnames\":[\"Jordan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Baggott\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Semprini\"],\"firstnames\":[\"Alex\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harwood\"],\"firstnames\":[\"Matire\"],\"suffixes\":[]}],\"month\":\"August\",\"year\":\"2020\",\"pmid\":\"32994594\",\"keywords\":\"Administration, Inhalation, Adult, Anti-Asthmatic Agents, Asthma, Bronchodilator Agents, Budesonide, Budesonide, Formoterol Fumarate Drug Combination, Case-Control Studies, Disease Progression, Drug Therapy, Combination, Ethnic Groups, Female, Humans, Male, Middle Aged, Nebulizers and Vaporizers, New Zealand, Outcome Assessment, Health Care, Terbutaline, Treatment Outcome\",\"pages\":\"61–72\",\"bibtex\":\"@article{hardy_combination_2020,\\n\\ttitle = {Combination budesonide/formoterol inhaler as sole reliever therapy in {Māori} and {Pacific} people with mild and moderate asthma},\\n\\tvolume = {133},\\n\\tissn = {1175-8716},\\n\\tabstract = {AIM: In the PRACTICAL study, as-needed budesonide/formoterol reduced the rate of severe exacerbations compared with maintenance budesonide plus as-needed terbutaline. In a pre-specified analysis we analysed the efficacy in Māori and Pacific peoples, populations with worse asthma outcomes.\\nMETHOD: The PRACTICAL study was a 52-week, open-label, parallel group, randomised controlled trial of 890 adults with mild to moderate asthma, who were randomised to budesonide/formoterol Turbuhaler 200/6mcg one actuation as required or budesonide Turbuhaler 200mcg one actuation twice daily and terbutaline Turbuhaler 250mcg two actuations as required. The primary outcome was rate of severe exacerbations. The analysis strategy was to test an ethnicity-treatment interaction term for each outcome variable.\\nRESULTS: Seventy-two participants (8\\\\%) identified as Māori, 36 participants (4\\\\%) as Pacific ethnicity. There was no evidence that ethnicity was an effect modifier for severe exacerbations (P interaction 0.70).\\nCONCLUSION: The reduction in severe exacerbation risk with budesonide-formoterol reliever compared with maintenance budesonide was similar in Māori and Pacific adults compared with New Zealand European/Other.},\\n\\tlanguage = {eng},\\n\\tnumber = {1520},\\n\\tjournal = {The New Zealand Medical Journal},\\n\\tauthor = {Hardy, Jo and Tewhaiti-Smith, Jordan and Baggott, Christina and Fingleton, James and Semprini, Alex and Holliday, Mark and Hancox, Robert J. and Weatherall, Mark and Harwood, Matire},\\n\\tmonth = aug,\\n\\tyear = {2020},\\n\\tpmid = {32994594},\\n\\tkeywords = {Administration, Inhalation, Adult, Anti-Asthmatic Agents, Asthma, Bronchodilator Agents, Budesonide, Budesonide, Formoterol Fumarate Drug Combination, Case-Control Studies, Disease Progression, Drug Therapy, Combination, Ethnic Groups, Female, Humans, Male, Middle Aged, Nebulizers and Vaporizers, New Zealand, Outcome Assessment, Health Care, Terbutaline, Treatment Outcome},\\n\\tpages = {61--72},\\n}\\n\\n\",\"author_short\":[\"Hardy, J.\",\"Tewhaiti-Smith, J.\",\"Baggott, C.\",\"Fingleton, J.\",\"Semprini, A.\",\"Holliday, M.\",\"Hancox, R. J.\",\"Weatherall, M.\",\"Harwood, M.\"],\"key\":\"hardy_combination_2020\",\"id\":\"hardy_combination_2020\",\"bibbaseid\":\"hardy-tewhaitismith-baggott-fingleton-semprini-holliday-hancox-weatherall-etal-combinationbudesonideformoterolinhalerassolerelievertherapyinmoriandpacificpeoplewithmildandmoderateasthma-2020\",\"role\":\"author\",\"urls\":{},\"keyword\":[\"Administration\",\"Inhalation\",\"Adult\",\"Anti-Asthmatic Agents\",\"Asthma\",\"Bronchodilator Agents\",\"Budesonide\",\"Budesonide\",\"Formoterol Fumarate Drug Combination\",\"Case-Control Studies\",\"Disease Progression\",\"Drug Therapy\",\"Combination\",\"Ethnic Groups\",\"Female\",\"Humans\",\"Male\",\"Middle Aged\",\"Nebulizers and Vaporizers\",\"New Zealand\",\"Outcome Assessment\",\"Health Care\",\"Terbutaline\",\"Treatment Outcome\"],\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Has the time come to end use of the blue inhaler?\",\"issn\":\"22132600\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855\",\"doi\":\"10.1016/S2213-2600(21)00185-5\",\"language\":\"en\",\"urldate\":\"2021-05-02\",\"journal\":\"The Lancet Respiratory Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Bush\"],\"firstnames\":[\"Andrew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Dalziel\"],\"firstnames\":[\"Stuart\",\"R\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Byrnes\"],\"firstnames\":[\"Catherine\",\"A\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hatter\"],\"firstnames\":[\"Lee\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"April\",\"year\":\"2021\",\"pages\":\"S2213260021001855\",\"bibtex\":\"@article{bush_has_2021,\\n\\ttitle = {Has the time come to end use of the blue inhaler?},\\n\\tissn = {22132600},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855},\\n\\tdoi = {10.1016/S2213-2600(21)00185-5},\\n\\tlanguage = {en},\\n\\turldate = {2021-05-02},\\n\\tjournal = {The Lancet Respiratory Medicine},\\n\\tauthor = {Bush, Andrew and Dalziel, Stuart R and Byrnes, Catherine A and Hatter, Lee and Beasley, Richard},\\n\\tmonth = apr,\\n\\tyear = {2021},\\n\\tpages = {S2213260021001855},\\n}\\n\\n\",\"author_short\":[\"Bush, A.\",\"Dalziel, S. R\",\"Byrnes, C. A\",\"Hatter, L.\",\"Beasley, R.\"],\"key\":\"bush_has_2021\",\"id\":\"bush_has_2021\",\"bibbaseid\":\"bush-dalziel-byrnes-hatter-beasley-hasthetimecometoenduseoftheblueinhaler-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Budesonide–formoterol reliever therapy in intermittent versus mild persistent asthma\",\"volume\":\"57\",\"issn\":\"0903-1936, 1399-3003\",\"url\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020\",\"doi\":\"10.1183/13993003.03064-2020\",\"language\":\"en\",\"number\":\"2\",\"urldate\":\"2021-04-30\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Papi\"],\"firstnames\":[\"Alberto\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ebmeier\"],\"firstnames\":[\"Stefan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harrison\"],\"firstnames\":[\"Tim\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Houghton\"],\"firstnames\":[\"Claire\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Morandi\"],\"firstnames\":[\"Luca\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Oldfield\"],\"firstnames\":[\"Karen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\",\"D.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"February\",\"year\":\"2021\",\"pages\":\"2003064\",\"bibtex\":\"@article{papi_budesonideformoterol_2021,\\n\\ttitle = {Budesonide–formoterol reliever therapy in intermittent versus mild persistent asthma},\\n\\tvolume = {57},\\n\\tissn = {0903-1936, 1399-3003},\\n\\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020},\\n\\tdoi = {10.1183/13993003.03064-2020},\\n\\tlanguage = {en},\\n\\tnumber = {2},\\n\\turldate = {2021-04-30},\\n\\tjournal = {European Respiratory Journal},\\n\\tauthor = {Papi, Alberto and Braithwaite, Irene and Ebmeier, Stefan and Hancox, Robert J. and Harrison, Tim and Holliday, Mark and Houghton, Claire and Morandi, Luca and Oldfield, Karen and Pavord, Ian D. and Reddel, Helen K. and Williams, Mathew and Weatherall, Mark and Beasley, Richard},\\n\\tmonth = feb,\\n\\tyear = {2021},\\n\\tpages = {2003064},\\n}\\n\\n\",\"author_short\":[\"Papi, A.\",\"Braithwaite, I.\",\"Ebmeier, S.\",\"Hancox, R. J.\",\"Harrison, T.\",\"Holliday, M.\",\"Houghton, C.\",\"Morandi, L.\",\"Oldfield, K.\",\"Pavord, I. D.\",\"Reddel, H. K.\",\"Williams, M.\",\"Weatherall, M.\",\"Beasley, R.\"],\"key\":\"papi_budesonideformoterol_2021\",\"id\":\"papi_budesonideformoterol_2021\",\"bibbaseid\":\"papi-braithwaite-ebmeier-hancox-harrison-holliday-houghton-morandi-etal-budesonideformoterolrelievertherapyinintermittentversusmildpersistentasthma-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":2,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD\",\"volume\":\"7\",\"issn\":\"2312-0541\",\"url\":\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020\",\"doi\":\"10.1183/23120541.00828-2020\",\"abstract\":\"Background The Respiratory Symptoms Questionnaire (RSQ) is a novel, four-item patient-reported diagnosis-agnostic tool designed to assess the frequency of respiratory symptoms and their impact on activity, without specifying a particular diagnosis. Our objective was to examine its validity in patients with asthma and/or chronic obstructive pulmonary disease (COPD). Methods Baseline data were randomly sampled from patients who completed the RSQ in the NOVELTY study ( ClinicalTrials.gov : NCT02760329 ). The total sample (n=1530) comprised three randomly selected samples (n=510 each) from each physician-assigned diagnostic group (asthma, asthma+COPD and COPD). The internal consistency and structural validity of the RSQ were evaluated using exploratory and confirmatory factor analyses; psychometric performance was observed using Classical Test Theory and Item Response Theory analyses. Results For the total sample, the mean± sd RSQ score was 5.6±4.3 (range 0–16). Irrespective of diagnosis, the internal consistency of items was uniformly adequate (Cronbach's α=0.76–0.80). All items had high factor loadings and structural characteristics of the measure were invariant across groups. Using the total sample, RSQ items informatively covered the θ score range of –2.0 to 2.8, with discrimination coefficients for individual items being high to very high (1.7–2.6). Strong convergent correlations were observed between the RSQ and the St George's Respiratory Questionnaire (0.77, p\\\\textless0.001). Conclusions The RSQ is a valid, brief, patient-reported tool for assessing respiratory symptoms in patients across the whole spectrum of asthma and/or COPD, rather than using different questionnaires for each diagnosis. It can be used for monitoring respiratory symptoms in clinical practice, clinical trials and real-world studies.\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2021-04-30\",\"journal\":\"ERJ Open Research\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Karlsson\"],\"firstnames\":[\"Niklas\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Atkinson\"],\"firstnames\":[\"Mark\",\"J.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Müllerová\"],\"firstnames\":[\"Hana\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Alacqua\"],\"firstnames\":[\"Marianna\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Keen\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hughes\"],\"firstnames\":[\"Rod\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Janson\"],\"firstnames\":[\"Christer\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Make\"],\"firstnames\":[\"Barry\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Price\"],\"firstnames\":[\"David\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K.\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2021\",\"pages\":\"00828–2020\",\"bibtex\":\"@article{karlsson_validation_2021,\\n\\ttitle = {Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or {COPD}},\\n\\tvolume = {7},\\n\\tissn = {2312-0541},\\n\\turl = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020},\\n\\tdoi = {10.1183/23120541.00828-2020},\\n\\tabstract = {Background\\n              The Respiratory Symptoms Questionnaire (RSQ) is a novel, four-item patient-reported diagnosis-agnostic tool designed to assess the frequency of respiratory symptoms and their impact on activity, without specifying a particular diagnosis. Our objective was to examine its validity in patients with asthma and/or chronic obstructive pulmonary disease (COPD).\\n            \\n            \\n              Methods\\n              \\n                Baseline data were randomly sampled from patients who completed the RSQ in the NOVELTY study (\\n                ClinicalTrials.gov\\n                :\\n                NCT02760329\\n                ). The total sample (n=1530) comprised three randomly selected samples (n=510 each) from each physician-assigned diagnostic group (asthma, asthma+COPD and COPD). The internal consistency and structural validity of the RSQ were evaluated using exploratory and confirmatory factor analyses; psychometric performance was observed using Classical Test Theory and Item Response Theory analyses.\\n              \\n            \\n            \\n              Results\\n              \\n                For the total sample, the mean±\\n                sd\\n                RSQ score was 5.6±4.3 (range 0–16). Irrespective of diagnosis, the internal consistency of items was uniformly adequate (Cronbach's α=0.76–0.80). All items had high factor loadings and structural characteristics of the measure were invariant across groups. Using the total sample, RSQ items informatively covered the θ score range of –2.0 to 2.8, with discrimination coefficients for individual items being high to very high (1.7–2.6). Strong convergent correlations were observed between the RSQ and the St George's Respiratory Questionnaire (0.77, p{\\\\textless}0.001).\\n              \\n            \\n            \\n              Conclusions\\n              The RSQ is a valid, brief, patient-reported tool for assessing respiratory symptoms in patients across the whole spectrum of asthma and/or COPD, rather than using different questionnaires for each diagnosis. It can be used for monitoring respiratory symptoms in clinical practice, clinical trials and real-world studies.},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2021-04-30},\\n\\tjournal = {ERJ Open Research},\\n\\tauthor = {Karlsson, Niklas and Atkinson, Mark J. and Müllerová, Hana and Alacqua, Marianna and Keen, Christina and Hughes, Rod and Janson, Christer and Make, Barry and Price, David and Reddel, Helen K.},\\n\\tmonth = jan,\\n\\tyear = {2021},\\n\\tpages = {00828--2020},\\n}\\n\\n\",\"author_short\":[\"Karlsson, N.\",\"Atkinson, M. J.\",\"Müllerová, H.\",\"Alacqua, M.\",\"Keen, C.\",\"Hughes, R.\",\"Janson, C.\",\"Make, B.\",\"Price, D.\",\"Reddel, H. K.\"],\"key\":\"karlsson_validation_2021\",\"id\":\"karlsson_validation_2021\",\"bibbaseid\":\"karlsson-atkinson-mllerov-alacqua-keen-hughes-janson-make-etal-validationofadiagnosisagnosticsymptomquestionnaireforasthmaandorcopd-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":2,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Balancing the needs of the many and the few: where next for adult asthma guidelines?\",\"issn\":\"22132600\",\"shorttitle\":\"Balancing the needs of the many and the few\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217\",\"doi\":\"10.1016/S2213-2600(21)00021-7\",\"language\":\"en\",\"urldate\":\"2021-04-28\",\"journal\":\"The Lancet Respiratory Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Shaw\"],\"firstnames\":[\"Dominick\",\"E\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Heaney\"],\"firstnames\":[\"Liam\",\"G\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Thomas\"],\"firstnames\":[\"Mike\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gibson\"],\"firstnames\":[\"Peter\",\"G\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\",\"D\"],\"suffixes\":[]}],\"month\":\"February\",\"year\":\"2021\",\"pages\":\"S2213260021000217\",\"bibtex\":\"@article{shaw_balancing_2021,\\n\\ttitle = {Balancing the needs of the many and the few: where next for adult asthma guidelines?},\\n\\tissn = {22132600},\\n\\tshorttitle = {Balancing the needs of the many and the few},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217},\\n\\tdoi = {10.1016/S2213-2600(21)00021-7},\\n\\tlanguage = {en},\\n\\turldate = {2021-04-28},\\n\\tjournal = {The Lancet Respiratory Medicine},\\n\\tauthor = {Shaw, Dominick E and Heaney, Liam G and Thomas, Mike and Beasley, Richard and Gibson, Peter G and Pavord, Ian D},\\n\\tmonth = feb,\\n\\tyear = {2021},\\n\\tpages = {S2213260021000217},\\n}\\n\\n\",\"author_short\":[\"Shaw, D. E\",\"Heaney, L. G\",\"Thomas, M.\",\"Beasley, R.\",\"Gibson, P. G\",\"Pavord, I. D\"],\"key\":\"shaw_balancing_2021\",\"id\":\"shaw_balancing_2021\",\"bibbaseid\":\"shaw-heaney-thomas-beasley-gibson-pavord-balancingtheneedsofthemanyandthefewwherenextforadultasthmaguidelines-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Heterogeneity within and between physician-diagnosed asthma and/or COPD: NOVELTY cohort\",\"issn\":\"0903-1936, 1399-3003\",\"shorttitle\":\"Heterogeneity within and between physician-diagnosed asthma and/or COPD\",\"url\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020\",\"doi\":\"10.1183/13993003.03927-2020\",\"abstract\":\"Background Studies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding of disease mechanisms and treatment options. NOVELTY is a global, 3-year, prospective observational study of patients with asthma and/or COPD from real-world clinical practice. We investigated heterogeneity and overlap by diagnosis and severity in this cohort. Methods Patients with physician-assigned asthma, COPD or both (asthma+COPD) were enrolled, stratified by diagnosis and severity. Baseline characteristics were reported descriptively by physician-assigned diagnosis and/or severity. Factors associated with physician-assessed severity were evaluated using ordinal logistic regression analysis. Results Of 11 243 patients, 5940 (52.8%) had physician-assigned asthma, 1396 (12.4%) had asthma+COPD and 3907 (34.8%) had COPD; almost half were from primary care. Symptoms, health-related quality of life and spirometry showed substantial heterogeneity and overlap between asthma, asthma+COPD and COPD, with 23%, 62% and 64% of patients, respectively, having post-bronchodilator FEV 1 /FVC \\\\textlesslower limit of normal. Symptoms and exacerbations increased with greater physician-assessed severity, and were higher in asthma+COPD, but 24.3% with mild asthma and 20.4% with mild COPD had experienced ≥1 exacerbation in the past 12 months. Medication records suggested both under-treatment and over-treatment relative to severity. Blood eosinophil counts varied little across diagnosis/severity groups, but blood neutrophil counts increased with severity across all diagnoses. Conclusion This analysis demonstrates marked heterogeneity within, and overlap between, physician-assigned diagnosis and severity groups in patients with asthma and/or COPD. Current diagnostic and severity classifications in clinical practice poorly differentiate between clinical phenotypes that may have specific risks and treatment implications.\",\"language\":\"en\",\"urldate\":\"2021-04-28\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vestbo\"],\"firstnames\":[\"Jørgen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Agustí\"],\"firstnames\":[\"Alvar\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Anderson\"],\"firstnames\":[\"Gary\",\"P\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bansal\"],\"firstnames\":[\"Aruna\",\"T\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bel\"],\"firstnames\":[\"Elisabeth\",\"H\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Janson\"],\"firstnames\":[\"Christer\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Make\"],\"firstnames\":[\"Barry\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\",\"D\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Price\"],\"firstnames\":[\"David\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Rapsomaniki\"],\"firstnames\":[\"Eleni\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Karlsson\"],\"firstnames\":[\"Niklas\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Finch\"],\"firstnames\":[\"Donna\",\"K\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Nuevo\"],\"firstnames\":[\"Javier\"],\"suffixes\":[]},{\"propositions\":[\"de\"],\"lastnames\":[\"Giorgio-Miller\"],\"firstnames\":[\"Alex\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Alacqua\"],\"firstnames\":[\"Marianna\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hughes\"],\"firstnames\":[\"Rod\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Müllerová\"],\"firstnames\":[\"Hana\"],\"suffixes\":[]},{\"propositions\":[\"Gerhardsson\",\"de\"],\"lastnames\":[\"Verdier\"],\"firstnames\":[\"Maria\"],\"suffixes\":[]}],\"month\":\"February\",\"year\":\"2021\",\"pages\":\"2003927\",\"bibtex\":\"@article{reddel_heterogeneity_2021,\\n\\ttitle = {Heterogeneity within and between physician-diagnosed asthma and/or {COPD}: {NOVELTY} cohort},\\n\\tissn = {0903-1936, 1399-3003},\\n\\tshorttitle = {Heterogeneity within and between physician-diagnosed asthma and/or {COPD}},\\n\\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020},\\n\\tdoi = {10.1183/13993003.03927-2020},\\n\\tabstract = {Background\\n              Studies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding of disease mechanisms and treatment options. NOVELTY is a global, 3-year, prospective observational study of patients with asthma and/or COPD from real-world clinical practice. We investigated heterogeneity and overlap by diagnosis and severity in this cohort.\\n            \\n            \\n              Methods\\n              Patients with physician-assigned asthma, COPD or both (asthma+COPD) were enrolled, stratified by diagnosis and severity. Baseline characteristics were reported descriptively by physician-assigned diagnosis and/or severity. Factors associated with physician-assessed severity were evaluated using ordinal logistic regression analysis.\\n            \\n            \\n              Results\\n              \\n                Of 11 243 patients, 5940 (52.8\\\\%) had physician-assigned asthma, 1396 (12.4\\\\%) had asthma+COPD and 3907 (34.8\\\\%) had COPD; almost half were from primary care. Symptoms, health-related quality of life and spirometry showed substantial heterogeneity and overlap between asthma, asthma+COPD and COPD, with 23\\\\%, 62\\\\% and 64\\\\% of patients, respectively, having post-bronchodilator FEV\\n                1\\n                /FVC {\\\\textless}lower limit of normal.\\n              \\n              Symptoms and exacerbations increased with greater physician-assessed severity, and were higher in asthma+COPD, but 24.3\\\\% with mild asthma and 20.4\\\\% with mild COPD had experienced ≥1 exacerbation in the past 12 months. Medication records suggested both under-treatment and over-treatment relative to severity. Blood eosinophil counts varied little across diagnosis/severity groups, but blood neutrophil counts increased with severity across all diagnoses.\\n            \\n            \\n              Conclusion\\n              This analysis demonstrates marked heterogeneity within, and overlap between, physician-assigned diagnosis and severity groups in patients with asthma and/or COPD. Current diagnostic and severity classifications in clinical practice poorly differentiate between clinical phenotypes that may have specific risks and treatment implications.},\\n\\tlanguage = {en},\\n\\turldate = {2021-04-28},\\n\\tjournal = {European Respiratory Journal},\\n\\tauthor = {Reddel, Helen K and Vestbo, Jørgen and Agustí, Alvar and Anderson, Gary P and Bansal, Aruna T and Beasley, Richard and Bel, Elisabeth H and Janson, Christer and Make, Barry and Pavord, Ian D and Price, David and Rapsomaniki, Eleni and Karlsson, Niklas and Finch, Donna K and Nuevo, Javier and de Giorgio-Miller, Alex and Alacqua, Marianna and Hughes, Rod and Müllerová, Hana and Gerhardsson de Verdier, Maria},\\n\\tmonth = feb,\\n\\tyear = {2021},\\n\\tpages = {2003927},\\n}\\n\\n\",\"author_short\":[\"Reddel, H. K\",\"Vestbo, J.\",\"Agustí, A.\",\"Anderson, G. P\",\"Bansal, A. T\",\"Beasley, R.\",\"Bel, E. H\",\"Janson, C.\",\"Make, B.\",\"Pavord, I. D\",\"Price, D.\",\"Rapsomaniki, E.\",\"Karlsson, N.\",\"Finch, D. K\",\"Nuevo, J.\",\"de Giorgio-Miller, A.\",\"Alacqua, M.\",\"Hughes, R.\",\"Müllerová, H.\",\"Gerhardsson de Verdier, M.\"],\"key\":\"reddel_heterogeneity_2021\",\"id\":\"reddel_heterogeneity_2021\",\"bibbaseid\":\"reddel-vestbo-agust-anderson-bansal-beasley-bel-janson-etal-heterogeneitywithinandbetweenphysiciandiagnosedasthmaandorcopdnoveltycohort-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"More options for managing severe asthma in adults\",\"volume\":\"9\",\"issn\":\"22132600\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982\",\"doi\":\"10.1016/S2213-2600(20)30398-2\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2021-04-28\",\"journal\":\"The Lancet Respiratory Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Chang\"],\"firstnames\":[\"Anne\",\"B\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2021\",\"pages\":\"3–5\",\"bibtex\":\"@article{chang_more_2021,\\n\\ttitle = {More options for managing severe asthma in adults},\\n\\tvolume = {9},\\n\\tissn = {22132600},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982},\\n\\tdoi = {10.1016/S2213-2600(20)30398-2},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2021-04-28},\\n\\tjournal = {The Lancet Respiratory Medicine},\\n\\tauthor = {Chang, Anne B and Beasley, Richard},\\n\\tmonth = jan,\\n\\tyear = {2021},\\n\\tpages = {3--5},\\n}\\n\\n\",\"author_short\":[\"Chang, A. B\",\"Beasley, R.\"],\"key\":\"chang_more_2021\",\"id\":\"chang_more_2021\",\"bibbaseid\":\"chang-beasley-moreoptionsformanagingsevereasthmainadults-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial\",\"issn\":\"00916749\",\"shorttitle\":\"Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X\",\"doi\":\"10.1016/j.jaci.2021.02.042\",\"language\":\"en\",\"urldate\":\"2021-04-28\",\"journal\":\"Journal of Allergy and Clinical Immunology\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\",\"E.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Cai\"],\"firstnames\":[\"Fang\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tom\"],\"firstnames\":[\"Jennifer\",\"A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Galanter\"],\"firstnames\":[\"Joshua\",\"M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Owen\"],\"firstnames\":[\"Ryan\",\"P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Zhu\"],\"firstnames\":[\"Rui\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"McGregor\"],\"firstnames\":[\"Anna\",\"G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Eliahu\"],\"firstnames\":[\"Avi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Durk\"],\"firstnames\":[\"Matthew\",\"R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Dengler\"],\"firstnames\":[\"Hart\",\"S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Zak\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kenny\"],\"firstnames\":[\"Jane\",\"R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Wilson\"],\"firstnames\":[\"Maria\",\"E.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chen\"],\"firstnames\":[\"Hubert\"],\"suffixes\":[]}],\"month\":\"March\",\"year\":\"2021\",\"pages\":\"S009167492100422X\",\"bibtex\":\"@article{braithwaite_inhaled_2021,\\n\\ttitle = {Inhaled {JAK} inhibitor {GDC}-0214 reduces exhaled nitric oxide in patients with mild asthma: {A} randomized, controlled, proof-of-activity trial},\\n\\tissn = {00916749},\\n\\tshorttitle = {Inhaled {JAK} inhibitor {GDC}-0214 reduces exhaled nitric oxide in patients with mild asthma},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X},\\n\\tdoi = {10.1016/j.jaci.2021.02.042},\\n\\tlanguage = {en},\\n\\turldate = {2021-04-28},\\n\\tjournal = {Journal of Allergy and Clinical Immunology},\\n\\tauthor = {Braithwaite, Irene E. and Cai, Fang and Tom, Jennifer A. and Galanter, Joshua M. and Owen, Ryan P. and Zhu, Rui and Williams, Mathew and McGregor, Anna G. and Eliahu, Avi and Durk, Matthew R. and Dengler, Hart S. and Zak, Mark and Kenny, Jane R. and Wilson, Maria E. and Beasley, Richard and Chen, Hubert},\\n\\tmonth = mar,\\n\\tyear = {2021},\\n\\tpages = {S009167492100422X},\\n}\\n\\n\",\"author_short\":[\"Braithwaite, I. E.\",\"Cai, F.\",\"Tom, J. A.\",\"Galanter, J. M.\",\"Owen, R. P.\",\"Zhu, R.\",\"Williams, M.\",\"McGregor, A. G.\",\"Eliahu, A.\",\"Durk, M. R.\",\"Dengler, H. S.\",\"Zak, M.\",\"Kenny, J. R.\",\"Wilson, M. E.\",\"Beasley, R.\",\"Chen, H.\"],\"key\":\"braithwaite_inhaled_2021\",\"id\":\"braithwaite_inhaled_2021\",\"bibbaseid\":\"braithwaite-cai-tom-galanter-owen-zhu-williams-mcgregor-etal-inhaledjakinhibitorgdc0214reducesexhalednitricoxideinpatientswithmildasthmaarandomizedcontrolledproofofactivitytrial-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"The Vexed Problem of Corticosteroid Toxicity in Asthma: Time for Standardized Assessment\",\"volume\":\"9\",\"issn\":\"22132198\",\"shorttitle\":\"The Vexed Problem of Corticosteroid Toxicity in Asthma\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193\",\"doi\":\"10.1016/j.jaip.2020.09.001\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2021-04-28\",\"journal\":\"The Journal of Allergy and Clinical Immunology: In Practice\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2021\",\"pages\":\"373–374\",\"bibtex\":\"@article{beasley_vexed_2021,\\n\\ttitle = {The {Vexed} {Problem} of {Corticosteroid} {Toxicity} in {Asthma}: {Time} for {Standardized} {Assessment}},\\n\\tvolume = {9},\\n\\tissn = {22132198},\\n\\tshorttitle = {The {Vexed} {Problem} of {Corticosteroid} {Toxicity} in {Asthma}},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193},\\n\\tdoi = {10.1016/j.jaip.2020.09.001},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2021-04-28},\\n\\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\\n\\tauthor = {Beasley, Richard and Weatherall, Mark},\\n\\tmonth = jan,\\n\\tyear = {2021},\\n\\tpages = {373--374},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Weatherall, M.\"],\"key\":\"beasley_vexed_2021\",\"id\":\"beasley_vexed_2021\",\"bibbaseid\":\"beasley-weatherall-thevexedproblemofcorticosteroidtoxicityinasthmatimeforstandardizedassessment-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Asthma and COVID-19: Preconceptions about Predisposition\",\"volume\":\"203\",\"issn\":\"1073-449X, 1535-4970\",\"shorttitle\":\"Asthma and COVID-19\",\"url\":\"https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED\",\"doi\":\"10.1164/rccm.202102-0266ED\",\"language\":\"en\",\"number\":\"7\",\"urldate\":\"2021-04-28\",\"journal\":\"American Journal of Respiratory and Critical Care Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hills\"],\"firstnames\":[\"Thomas\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kearns\"],\"firstnames\":[\"Nethmi\"],\"suffixes\":[]}],\"month\":\"April\",\"year\":\"2021\",\"pages\":\"799–801\",\"bibtex\":\"@article{beasley_asthma_2021-1,\\n\\ttitle = {Asthma and {COVID}-19: {Preconceptions} about {Predisposition}},\\n\\tvolume = {203},\\n\\tissn = {1073-449X, 1535-4970},\\n\\tshorttitle = {Asthma and {COVID}-19},\\n\\turl = {https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED},\\n\\tdoi = {10.1164/rccm.202102-0266ED},\\n\\tlanguage = {en},\\n\\tnumber = {7},\\n\\turldate = {2021-04-28},\\n\\tjournal = {American Journal of Respiratory and Critical Care Medicine},\\n\\tauthor = {Beasley, Richard and Hills, Thomas and Kearns, Nethmi},\\n\\tmonth = apr,\\n\\tyear = {2021},\\n\\tpages = {799--801},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Hills, T.\",\"Kearns, N.\"],\"key\":\"beasley_asthma_2021-1\",\"id\":\"beasley_asthma_2021-1\",\"bibbaseid\":\"beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":2,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"ICS-formoterol reliever versus ICS and short-acting β2 -agonist reliever in asthma: a systematic review and meta-analysis\",\"volume\":\"7\",\"issn\":\"2312-0541\",\"shorttitle\":\"ICS-formoterol reliever <i>versus</i> ICS and short-acting β $_{\\\\textrm{2}}$ -agonist reliever in asthma\",\"url\":\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020\",\"doi\":\"10.1183/23120541.00701-2020\",\"abstract\":\"Background The Global Initiative for Asthma recommends as-needed inhaled corticosteroid (ICS)-formoterol as an alternative to maintenance ICS plus short-acting β 2 -agonist (SABA) reliever at step 2 of its stepwise treatment algorithm. Our aim was to assess the efficacy and safety of these two treatment regimens, with a focus on prevention of severe exacerbation. Methods We performed a systematic review and meta-analysis of all randomised controlled trials (RCTs) comparing as-needed ICS-formoterol with maintenance ICS plus SABA. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrials.gov were searched from database inception to 12 December 2019. The primary outcome was time to first severe exacerbation. RCTs were excluded if they used as-needed budesonide-formoterol as part of a maintenance and reliever regimen, or did not report on severe exacerbations. The review is registered with PROSPERO (identifier number CRD42020154680). Results Four RCTs (n=8065 participants) were included in the analysis. As-needed ICS-formoterol was associated with a prolonged time to first severe exacerbation (hazard ratio 0.85, 95% CI 0.73–1.00; p=0.048) and reduced daily ICS dose (mean difference −177.3 μg, 95% CI −182.2–−172.4 μg). Asthma symptom control was worse in the as-needed group (Asthma Control Questionnaire-5 mean difference 0.12, 95% CI 0.09–0.14), although this did not meet the minimal clinically important difference of 0.50 units. There was no significant difference in serious adverse events (OR 1.07, 95% CI 0.84–1.36). Conclusion As-needed ICS-formoterol offers a therapeutic alternative to maintenance low-dose ICS plus SABA in asthma and may be the preferred option when prevention of severe exacerbation is the primary aim of treatment.\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2021-04-28\",\"journal\":\"ERJ Open Research\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Hatter\"],\"firstnames\":[\"Lee\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bruce\"],\"firstnames\":[\"Pepa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"firstnames\":[],\"propositions\":[],\"lastnames\":[\"James Fingleton\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2021\",\"pages\":\"00701–2020\",\"bibtex\":\"@article{hatter_ics-formoterol_2021,\\n\\ttitle = {{ICS}-formoterol reliever versus {ICS} and short-acting β2 -agonist reliever in asthma: a systematic review and meta-analysis},\\n\\tvolume = {7},\\n\\tissn = {2312-0541},\\n\\tshorttitle = {{ICS}-formoterol reliever \\\\textit{versus} {ICS} and short-acting β $_{\\\\textrm{2}}$ -agonist reliever in asthma},\\n\\turl = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020},\\n\\tdoi = {10.1183/23120541.00701-2020},\\n\\tabstract = {Background\\n              \\n                The Global Initiative for Asthma recommends as-needed inhaled corticosteroid (ICS)-formoterol as an alternative to maintenance ICS plus short-acting β\\n                2\\n                -agonist (SABA) reliever at step 2 of its stepwise treatment algorithm. Our aim was to assess the efficacy and safety of these two treatment regimens, with a focus on prevention of severe exacerbation.\\n              \\n            \\n            \\n              Methods\\n              We performed a systematic review and meta-analysis of all randomised controlled trials (RCTs) comparing as-needed ICS-formoterol with maintenance ICS plus SABA. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrials.gov were searched from database inception to 12 December 2019. The primary outcome was time to first severe exacerbation. RCTs were excluded if they used as-needed budesonide-formoterol as part of a maintenance and reliever regimen, or did not report on severe exacerbations. The review is registered with PROSPERO (identifier number CRD42020154680).\\n            \\n            \\n              Results\\n              Four RCTs (n=8065 participants) were included in the analysis. As-needed ICS-formoterol was associated with a prolonged time to first severe exacerbation (hazard ratio 0.85, 95\\\\% CI 0.73–1.00; p=0.048) and reduced daily ICS dose (mean difference −177.3 μg, 95\\\\% CI −182.2–−172.4 μg). Asthma symptom control was worse in the as-needed group (Asthma Control Questionnaire-5 mean difference 0.12, 95\\\\% CI 0.09–0.14), although this did not meet the minimal clinically important difference of 0.50 units. There was no significant difference in serious adverse events (OR 1.07, 95\\\\% CI 0.84–1.36).\\n            \\n            \\n              Conclusion\\n              As-needed ICS-formoterol offers a therapeutic alternative to maintenance low-dose ICS plus SABA in asthma and may be the preferred option when prevention of severe exacerbation is the primary aim of treatment.},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2021-04-28},\\n\\tjournal = {ERJ Open Research},\\n\\tauthor = {Hatter, Lee and Bruce, Pepa and Braithwaite, Irene and Holliday, Mark and {James Fingleton} and Weatherall, Mark and Beasley, Richard},\\n\\tmonth = jan,\\n\\tyear = {2021},\\n\\tpages = {00701--2020},\\n}\\n\\n\",\"author_short\":[\"Hatter, L.\",\"Bruce, P.\",\"Braithwaite, I.\",\"Holliday, M.\",\"James Fingleton\",\"Weatherall, M.\",\"Beasley, R.\"],\"key\":\"hatter_ics-formoterol_2021\",\"id\":\"hatter_ics-formoterol_2021\",\"bibbaseid\":\"hatter-bruce-braithwaite-holliday-jamesfingleton-weatherall-beasley-icsformoterolrelieverversusicsandshortacting2agonistrelieverinasthmaasystematicreviewandmetaanalysis-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"The management of mild asthma\",\"volume\":\"57\",\"issn\":\"0903-1936, 1399-3003\",\"url\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020\",\"doi\":\"10.1183/13993003.03051-2020\",\"abstract\":\"Inhaled corticosteroids (ICSs) have been recommended as a maintenance treatment, either alone or together with long-acting inhaled β 2 -agonists, for all asthma patients. Short-acting β 2 -agonists (SABAs) are rapid-onset bronchodilators, which provide symptom relief, but have no anti-inflammatory properties, yet are the most widely used as-needed reliever treatment for asthma and often the only treatment prescribed. Asthma patients can find adhering to daily preventative medication with ICS difficult and will often revert to using as-needed SABA as their only treatment, increasing their risk of exacerbations. The purpose of this review is to evaluate the efficacy of reliever medications that contain ICS compared with SABA as reliever, or with maintenance ICS and SABA as reliever, in mild asthma patients. Nine studies were identified that have evaluated the use of ICS as a component of an as-needed reliever in patients with mild asthma. Four of the most recent studies compared the combination of ICS/formoterol to SABA as reliever. ICS-containing reliever medication was superior to SABA as reliever alone, and was equivalent to maintenance ICS and SABA as reliever, particularly in reducing risks of severe asthma exacerbations, in studies which compared these reliever options. SABAs should not be used as a reliever without ICS. The concern about patients with mild asthma not being adherent to maintenance ICS supports a recommendation that ICS/formoterol should be considered as a treatment option instead of maintenance ICS, to avoid the risk of patients reverting to SABA alone.\",\"language\":\"en\",\"number\":\"4\",\"urldate\":\"2021-04-11\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"O'Byrne\"],\"firstnames\":[\"Paul\",\"M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"April\",\"year\":\"2021\",\"pages\":\"2003051\",\"bibtex\":\"@article{obyrne_management_2021,\\n\\ttitle = {The management of mild asthma},\\n\\tvolume = {57},\\n\\tissn = {0903-1936, 1399-3003},\\n\\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020},\\n\\tdoi = {10.1183/13993003.03051-2020},\\n\\tabstract = {Inhaled corticosteroids (ICSs) have been recommended as a maintenance treatment, either alone or together with long-acting inhaled β\\n              2\\n              -agonists, for all asthma patients. Short-acting β\\n              2\\n              -agonists (SABAs) are rapid-onset bronchodilators, which provide symptom relief, but have no anti-inflammatory properties, yet are the most widely used as-needed reliever treatment for asthma and often the only treatment prescribed. Asthma patients can find adhering to daily preventative medication with ICS difficult and will often revert to using as-needed SABA as their only treatment, increasing their risk of exacerbations. The purpose of this review is to evaluate the efficacy of reliever medications that contain ICS compared with SABA as reliever, or with maintenance ICS and SABA as reliever, in mild asthma patients.\\n            \\n            Nine studies were identified that have evaluated the use of ICS as a component of an as-needed reliever in patients with mild asthma. Four of the most recent studies compared the combination of ICS/formoterol to SABA as reliever.\\n            ICS-containing reliever medication was superior to SABA as reliever alone, and was equivalent to maintenance ICS and SABA as reliever, particularly in reducing risks of severe asthma exacerbations, in studies which compared these reliever options.\\n            SABAs should not be used as a reliever without ICS. The concern about patients with mild asthma not being adherent to maintenance ICS supports a recommendation that ICS/formoterol should be considered as a treatment option instead of maintenance ICS, to avoid the risk of patients reverting to SABA alone.},\\n\\tlanguage = {en},\\n\\tnumber = {4},\\n\\turldate = {2021-04-11},\\n\\tjournal = {European Respiratory Journal},\\n\\tauthor = {O'Byrne, Paul M. and Reddel, Helen K. and Beasley, Richard},\\n\\tmonth = apr,\\n\\tyear = {2021},\\n\\tpages = {2003051},\\n}\\n\\n\",\"author_short\":[\"O'Byrne, P. M.\",\"Reddel, H. K.\",\"Beasley, R.\"],\"key\":\"obyrne_management_2021\",\"id\":\"obyrne_management_2021\",\"bibbaseid\":\"obyrne-reddel-beasley-themanagementofmildasthma-2021\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Patient preferences for asthma management: a qualitative study\",\"volume\":\"10\",\"issn\":\"2044-6055, 2044-6055\",\"shorttitle\":\"Patient preferences for asthma management\",\"url\":\"http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491\",\"doi\":\"10.1136/bmjopen-2020-037491\",\"abstract\":\"Objective Preference for asthma management and the use of medications is motivated by the interplay between lived experiences of asthma and patients’ attitudes towards medications. Many previous studies have focused on individual aspects of asthma management, such as the use of preventer and reliever inhalers. The aim of this qualitative study was to explore the preferences of patients with mild-moderate asthma for asthma management as a whole and factors that influenced these preferences. Design A qualitative study employing qualitative descriptive analysis situated within a constructionist epistemology to analyse transcribed audio recordings from focus groups. Setting Three locations within the greater Wellington area in New Zealand. Participants Twenty-seven adults with self-reported doctor’s diagnosis of asthma, taking short-acting beta-agonists alone or inhaled corticosteroids with or without long-acting beta 2 -agonist, who had used any inhaled asthma medication within the last month. Results Four key areas described preferences for asthma management. Preferences for self-management: participants wanted to be in control of their asthma and developed personal strategies to achieve this. Preferences for the specific medications or treatment regimen: participants preferred regimens that were convenient and reliably relieved symptoms. Preferences for inhaler devices: devices that had dose counters and were easy to use and portable were important. Preferences for asthma services: participants wanted easier access to their inhalers and to be empowered by their healthcare providers. Participant preferences within each of these four areas were influenced by the impact asthma had on their life, their health beliefs, emotional consequences of asthma and perceived barriers to asthma management. Conclusions This study illustrates the interaction of the lived experience of asthma, factors specific to the individual, and factors relating to asthma treatments in shaping patient preferences for asthma management. This aids our understanding of preferences for asthma management from the patient perspective. Trial registration number Australian New Zealand Clinical Trials Registry (ACTRN12619000601134).\",\"language\":\"en\",\"number\":\"8\",\"urldate\":\"2020-09-03\",\"journal\":\"BMJ Open\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Baggott\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chan\"],\"firstnames\":[\"Amy\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hurford\"],\"firstnames\":[\"Sally\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harwood\"],\"firstnames\":[\"Matire\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Levack\"],\"firstnames\":[\"William\",\"Mark\",\"Magnus\"],\"suffixes\":[]}],\"month\":\"August\",\"year\":\"2020\",\"note\":\"Number: 8\",\"pages\":\"e037491\",\"bibtex\":\"@article{baggott_patient_2020-1,\\n\\ttitle = {Patient preferences for asthma management: a qualitative study},\\n\\tvolume = {10},\\n\\tissn = {2044-6055, 2044-6055},\\n\\tshorttitle = {Patient preferences for asthma management},\\n\\turl = {http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491},\\n\\tdoi = {10.1136/bmjopen-2020-037491},\\n\\tabstract = {Objective\\n              Preference for asthma management and the use of medications is motivated by the interplay between lived experiences of asthma and patients’ attitudes towards medications. Many previous studies have focused on individual aspects of asthma management, such as the use of preventer and reliever inhalers. The aim of this qualitative study was to explore the preferences of patients with mild-moderate asthma for asthma management as a whole and factors that influenced these preferences.\\n            \\n            \\n              Design\\n              A qualitative study employing qualitative descriptive analysis situated within a constructionist epistemology to analyse transcribed audio recordings from focus groups.\\n            \\n            \\n              Setting\\n              Three locations within the greater Wellington area in New Zealand.\\n            \\n            \\n              Participants\\n              \\n                Twenty-seven adults with self-reported doctor’s diagnosis of asthma, taking short-acting beta-agonists alone or inhaled corticosteroids with or without long-acting beta\\n                2\\n                -agonist, who had used any inhaled asthma medication within the last month.\\n              \\n            \\n            \\n              Results\\n              Four key areas described preferences for asthma management. Preferences for self-management: participants wanted to be in control of their asthma and developed personal strategies to achieve this. Preferences for the specific medications or treatment regimen: participants preferred regimens that were convenient and reliably relieved symptoms. Preferences for inhaler devices: devices that had dose counters and were easy to use and portable were important. Preferences for asthma services: participants wanted easier access to their inhalers and to be empowered by their healthcare providers. Participant preferences within each of these four areas were influenced by the impact asthma had on their life, their health beliefs, emotional consequences of asthma and perceived barriers to asthma management.\\n            \\n            \\n              Conclusions\\n              This study illustrates the interaction of the lived experience of asthma, factors specific to the individual, and factors relating to asthma treatments in shaping patient preferences for asthma management. This aids our understanding of preferences for asthma management from the patient perspective.\\n            \\n            \\n              Trial registration number\\n              Australian New Zealand Clinical Trials Registry (ACTRN12619000601134).},\\n\\tlanguage = {en},\\n\\tnumber = {8},\\n\\turldate = {2020-09-03},\\n\\tjournal = {BMJ Open},\\n\\tauthor = {Baggott, Christina and Chan, Amy and Hurford, Sally and Fingleton, James and Beasley, Richard and Harwood, Matire and Reddel, Helen K and Levack, William Mark Magnus},\\n\\tmonth = aug,\\n\\tyear = {2020},\\n\\tnote = {Number: 8},\\n\\tpages = {e037491},\\n}\\n\\n\",\"author_short\":[\"Baggott, C.\",\"Chan, A.\",\"Hurford, S.\",\"Fingleton, J.\",\"Beasley, R.\",\"Harwood, M.\",\"Reddel, H. K\",\"Levack, W. M. M.\"],\"key\":\"baggott_patient_2020-1\",\"id\":\"baggott_patient_2020-1\",\"bibbaseid\":\"baggott-chan-hurford-fingleton-beasley-harwood-reddel-levack-patientpreferencesforasthmamanagementaqualitativestudy-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Self-titration of inhaled corticosteroid and β2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial\",\"volume\":\"56\",\"issn\":\"0903-1936, 1399-3003\",\"shorttitle\":\"Self-titration of inhaled corticosteroid and β $_{\\\\textrm{2}}$ -agonist in response to symptoms in mild asthma\",\"url\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020\",\"doi\":\"10.1183/13993003.00170-2020\",\"abstract\":\"Introduction In mild asthma, as-needed budesonide–formoterol is superior or noninferior to maintenance budesonide plus as-needed short-acting β 2 -agonist in reducing severe exacerbations. In this pre-specified analysis, we investigated patterns of inhaled corticosteroid (ICS) and β 2 -agonist use in PRACTICAL, a randomised controlled trial. Methods Participants were randomised 1:1 to as-needed budesonide–formoterol (200/6 μg Turbuhaler, one actuation) or maintenance budesonide (200 μg Turbuhaler, one actuation twice a day) with as-needed terbutaline (250 μg, two actuations) for 52 weeks. 110 participants had electronic monitors attached to their study inhalers which captured the time and date of every actuation. Key outcome measures were patterns of ICS and β 2 -agonist use. One actuation of budesonide–formoterol was considered to be an equivalent bronchodilator dose as two actuations of terbutaline. Results Participants randomised to as-needed budesonide–formoterol had more days with no ICS use compared with maintenance budesonide (median total days of no use 156 versus 22 days, respectively), lower median daily budesonide dose (164 versus 328 μg, respectively) and a greater median number of days of ≥4 budesonide actuations (4 versus 1 days, respectively). Participants randomised to as-needed budesonide–formoterol took higher equivalent doses of β 2 -agonist both overall (median number of actuations 0.8 versus 0.3 per day, respectively) and in response to worsening asthma (total number of “overuse days” of \\\\textgreater8 or \\\\textgreater16 actuations of budesonide–formoterol or terbutaline 33 versus 10 days, respectively). Conclusions The timing of ICS dose when self-titrated to β 2 -agonist use is more important than total ICS dose in reducing severe exacerbation risk in mild asthma, when associated with greater overall use of as-needed β 2 -agonist.\",\"language\":\"en\",\"number\":\"4\",\"urldate\":\"2020-10-13\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Baggott\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hardy\"],\"firstnames\":[\"Jo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sparks\"],\"firstnames\":[\"Jenny\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hall\"],\"firstnames\":[\"Daniela\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vohlidkova\"],\"firstnames\":[\"Alexandra\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"October\",\"year\":\"2020\",\"note\":\"Number: 4\",\"pages\":\"2000170\",\"bibtex\":\"@article{baggott_self-titration_2020,\\n\\ttitle = {Self-titration of inhaled corticosteroid and β2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the {PRACTICAL} randomised controlled trial},\\n\\tvolume = {56},\\n\\tissn = {0903-1936, 1399-3003},\\n\\tshorttitle = {Self-titration of inhaled corticosteroid and β $_{\\\\textrm{2}}$ -agonist in response to symptoms in mild asthma},\\n\\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020},\\n\\tdoi = {10.1183/13993003.00170-2020},\\n\\tabstract = {Introduction\\n              \\n                In mild asthma, as-needed budesonide–formoterol is superior or noninferior to maintenance budesonide plus as-needed short-acting β\\n                2\\n                -agonist in reducing severe exacerbations. In this pre-specified analysis, we investigated patterns of inhaled corticosteroid (ICS) and β\\n                2\\n                -agonist use in PRACTICAL, a randomised controlled trial.\\n              \\n            \\n            \\n              Methods\\n              \\n                Participants were randomised 1:1 to as-needed budesonide–formoterol (200/6 μg Turbuhaler, one actuation) or maintenance budesonide (200 μg Turbuhaler, one actuation twice a day) with as-needed terbutaline (250 μg, two actuations) for 52 weeks. 110 participants had electronic monitors attached to their study inhalers which captured the time and date of every actuation. Key outcome measures were patterns of ICS and β\\n                2\\n                -agonist use. One actuation of budesonide–formoterol was considered to be an equivalent bronchodilator dose as two actuations of terbutaline.\\n              \\n            \\n            \\n              Results\\n              \\n                Participants randomised to as-needed budesonide–formoterol had more days with no ICS use compared with maintenance budesonide (median total days of no use 156\\n                versus\\n                22 days, respectively), lower median daily budesonide dose (164\\n                versus\\n                328 μg, respectively) and a greater median number of days of ≥4 budesonide actuations (4\\n                versus\\n                1 days, respectively). Participants randomised to as-needed budesonide–formoterol took higher equivalent doses of β\\n                2\\n                -agonist both overall (median number of actuations 0.8\\n                versus\\n                0.3 per day, respectively) and in response to worsening asthma (total number of “overuse days” of {\\\\textgreater}8 or {\\\\textgreater}16 actuations of budesonide–formoterol or terbutaline 33\\n                versus\\n                10 days, respectively).\\n              \\n            \\n            \\n              Conclusions\\n              \\n                The timing of ICS dose when self-titrated to β\\n                2\\n                -agonist use is more important than total ICS dose in reducing severe exacerbation risk in mild asthma, when associated with greater overall use of as-needed β\\n                2\\n                -agonist.},\\n\\tlanguage = {en},\\n\\tnumber = {4},\\n\\turldate = {2020-10-13},\\n\\tjournal = {European Respiratory Journal},\\n\\tauthor = {Baggott, Christina and Hardy, Jo and Sparks, Jenny and Holliday, Mark and Hall, Daniela and Vohlidkova, Alexandra and Hancox, Robert J. and Weatherall, Mark and Fingleton, James and Beasley, Richard},\\n\\tmonth = oct,\\n\\tyear = {2020},\\n\\tnote = {Number: 4},\\n\\tpages = {2000170},\\n}\\n\\n\",\"author_short\":[\"Baggott, C.\",\"Hardy, J.\",\"Sparks, J.\",\"Holliday, M.\",\"Hall, D.\",\"Vohlidkova, A.\",\"Hancox, R. J.\",\"Weatherall, M.\",\"Fingleton, J.\",\"Beasley, R.\"],\"key\":\"baggott_self-titration_2020\",\"id\":\"baggott_self-titration_2020\",\"bibbaseid\":\"baggott-hardy-sparks-holliday-hall-vohlidkova-hancox-weatherall-etal-selftitrationofinhaledcorticosteroidand2agonistinresponsetosymptomsinmildasthmaaprespecifiedanalysisfromthepracticalrandomisedcontrolledtrial-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Inhaled Corticosteroids in Acute Asthma: A Systemic Review and Meta-Analysis\",\"volume\":\"8\",\"issn\":\"22132198\",\"shorttitle\":\"Inhaled Corticosteroids in Acute Asthma\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767\",\"doi\":\"10.1016/j.jaip.2019.08.051\",\"language\":\"en\",\"number\":\"2\",\"urldate\":\"2020-09-28\",\"journal\":\"The Journal of Allergy and Clinical Immunology: In Practice\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Kearns\"],\"firstnames\":[\"Nethmi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Maijers\"],\"firstnames\":[\"Ingrid\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harper\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]}],\"month\":\"February\",\"year\":\"2020\",\"note\":\"Number: 2\",\"pages\":\"605–617.e6\",\"bibtex\":\"@article{kearns_inhaled_2020,\\n\\ttitle = {Inhaled {Corticosteroids} in {Acute} {Asthma}: {A} {Systemic} {Review} and {Meta}-{Analysis}},\\n\\tvolume = {8},\\n\\tissn = {22132198},\\n\\tshorttitle = {Inhaled {Corticosteroids} in {Acute} {Asthma}},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767},\\n\\tdoi = {10.1016/j.jaip.2019.08.051},\\n\\tlanguage = {en},\\n\\tnumber = {2},\\n\\turldate = {2020-09-28},\\n\\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\\n\\tauthor = {Kearns, Nethmi and Maijers, Ingrid and Harper, James and Beasley, Richard and Weatherall, Mark},\\n\\tmonth = feb,\\n\\tyear = {2020},\\n\\tnote = {Number: 2},\\n\\tpages = {605--617.e6},\\n}\\n\\n\",\"author_short\":[\"Kearns, N.\",\"Maijers, I.\",\"Harper, J.\",\"Beasley, R.\",\"Weatherall, M.\"],\"key\":\"kearns_inhaled_2020\",\"id\":\"kearns_inhaled_2020\",\"bibbaseid\":\"kearns-maijers-harper-beasley-weatherall-inhaledcorticosteroidsinacuteasthmaasystemicreviewandmetaanalysis-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Reducing the burden of asthma: time to set research and clinical priorities\",\"issn\":\"22132600\",\"shorttitle\":\"Reducing the burden of asthma\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008\",\"doi\":\"10.1016/S2213-2600(20)30400-8\",\"language\":\"en\",\"urldate\":\"2020-09-11\",\"journal\":\"The Lancet Respiratory Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J\"],\"suffixes\":[]}],\"month\":\"September\",\"year\":\"2020\",\"pages\":\"S2213260020304008\",\"bibtex\":\"@article{beasley_reducing_2020,\\n\\ttitle = {Reducing the burden of asthma: time to set research and clinical priorities},\\n\\tissn = {22132600},\\n\\tshorttitle = {Reducing the burden of asthma},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008},\\n\\tdoi = {10.1016/S2213-2600(20)30400-8},\\n\\tlanguage = {en},\\n\\turldate = {2020-09-11},\\n\\tjournal = {The Lancet Respiratory Medicine},\\n\\tauthor = {Beasley, Richard and Hancox, Robert J},\\n\\tmonth = sep,\\n\\tyear = {2020},\\n\\tpages = {S2213260020304008},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Hancox, R. J\"],\"key\":\"beasley_reducing_2020\",\"id\":\"beasley_reducing_2020\",\"bibbaseid\":\"beasley-hancox-reducingtheburdenofasthmatimetosetresearchandclinicalpriorities-2020\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Change in biomarkers of type-2 inflammation following severe exacerbations of asthma\",\"volume\":\"74\",\"issn\":\"0040-6376, 1468-3296\",\"url\":\"http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657\",\"doi\":\"10.1136/thoraxjnl-2018-211657\",\"abstract\":\"We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33×10 9 /L, p\\\\textless0.001) while serum IgE levels were at their highest (339 vs 249 U/L, p\\\\textless0.001). Fractional exhaled Nitric Oxide levels were lowest 2 weeks after treatment (23 vs 33 ppb, p=0.06) and serum periostin levels were lowest 1 week after treatment (45·9 vs 50·9 ng/mL, p\\\\textless0.001). A delay of 4–8 weeks following a severe exacerbation is required if these biomarkers are used to guide the ongoing management of patients with asthma. Trial registration number Post-results; The Australia New Zealand Trial Registry, \\\\textgreaterACTRN12614000443695.\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2020-08-23\",\"journal\":\"Thorax\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Semprini\"],\"firstnames\":[\"Ruth\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shortt\"],\"firstnames\":[\"Nick\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ebmeier\"],\"firstnames\":[\"Stefan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Semprini\"],\"firstnames\":[\"Alex\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Varughese\"],\"firstnames\":[\"Rachel\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holweg\"],\"firstnames\":[\"Cecile\",\"T\",\"J\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Matthews\"],\"firstnames\":[\"John\",\"G\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2019\",\"note\":\"Number: 1\",\"pages\":\"95–98\",\"bibtex\":\"@article{semprini_change_2019,\\n\\ttitle = {Change in biomarkers of type-2 inflammation following severe exacerbations of asthma},\\n\\tvolume = {74},\\n\\tissn = {0040-6376, 1468-3296},\\n\\turl = {http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657},\\n\\tdoi = {10.1136/thoraxjnl-2018-211657},\\n\\tabstract = {We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33×10\\n              9\\n              /L, p{\\\\textless}0.001) while serum IgE levels were at their highest (339 vs 249 U/L, p{\\\\textless}0.001). Fractional exhaled Nitric Oxide levels were lowest 2 weeks after treatment (23 vs 33 ppb, p=0.06) and serum periostin levels were lowest 1 week after treatment (45·9 vs 50·9 ng/mL, p{\\\\textless}0.001). A delay of 4–8 weeks following a severe exacerbation is required if these biomarkers are used to guide the ongoing management of patients with asthma.\\n            \\n            \\n              Trial registration number\\n              Post-results; The Australia New Zealand Trial Registry, {\\\\textgreater}ACTRN12614000443695.},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2020-08-23},\\n\\tjournal = {Thorax},\\n\\tauthor = {Semprini, Ruth and Shortt, Nick and Ebmeier, Stefan and Semprini, Alex and Varughese, Rachel and Holweg, Cecile T J and Matthews, John G and Fingleton, James and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},\\n\\tmonth = jan,\\n\\tyear = {2019},\\n\\tnote = {Number: 1},\\n\\tpages = {95--98},\\n}\\n\\n\",\"author_short\":[\"Semprini, R.\",\"Shortt, N.\",\"Ebmeier, S.\",\"Semprini, A.\",\"Varughese, R.\",\"Holweg, C. T J\",\"Matthews, J. G\",\"Fingleton, J.\",\"Weatherall, M.\",\"Beasley, R.\",\"Braithwaite, I.\"],\"key\":\"semprini_change_2019\",\"id\":\"semprini_change_2019\",\"bibbaseid\":\"semprini-shortt-ebmeier-semprini-varughese-holweg-matthews-fingleton-etal-changeinbiomarkersoftype2inflammationfollowingsevereexacerbationsofasthma-2019\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: ISAAC phase III\",\"volume\":\"74\",\"issn\":\"0040-6376, 1468-3296\",\"shorttitle\":\"Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children\",\"url\":\"http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668\",\"doi\":\"10.1136/thoraxjnl-2018-212668\",\"abstract\":\"Background Asthma is not the key focus of prevention strategies. A Healthy Lifestyle Index (HLI) was developed to examine the combined effect of modifiable lifestyle factors on asthma, rhinoconjunctivitis and eczema using data from the International Study of Asthma and Allergies in Childhood (ISAAC) phase III. Methods Information on symptoms of asthma, rhinoconjunctivitis, eczema and several lifestyle factors was obtained from children aged 6–7 years through written questionnaires. The HLI combined five lifestyle factors: no parental smoking, child’s adherence to Mediterranean diet, child’s healthy body mass index, high physical activity and non-sedentary behaviour. The association between the HLI and risk of asthma, rhinoconjunctivitis and eczema was evaluated using multilevel mixed-effects logistic regression models. Findings Data of 70 795 children from 37 centres in 19 countries were analysed. Each additional healthy lifestyle factor was associated with a reduced risk of current wheeze (OR 0.87, 95% CI 0.84 to 0.89), asthma ever (OR 0.89, 95% CI 0.87 to 0.92), current symptoms of rhinoconjunctivitis (OR 0.95, 95% CI 0.92 to 0.97) and current symptoms of eczema (OR 0.92, 95% CI 0.92 to 0.98). Theoretically, if associations were causal, a combination of four or five healthy lifestyle factors would result into a reduction up to 16% of asthma cases (ranging from 2.7% to 26.3 % according to region of the world). Conclusions These findings should be interpreted with caution given the limitations to infer causality from cross-sectional observational data. Efficacy of interventions to improve multiple modifiable lifestyle factors to reduce the burden asthma and allergy in childhood should be assessed.\",\"language\":\"en\",\"number\":\"6\",\"urldate\":\"2020-08-23\",\"journal\":\"Thorax\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Morales\"],\"firstnames\":[\"Eva\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Strachan\"],\"firstnames\":[\"David\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Asher\"],\"firstnames\":[\"Innes\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ellwood\"],\"firstnames\":[\"Philippa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pearce\"],\"firstnames\":[\"Neil\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Garcia-Marcos\"],\"firstnames\":[\"Luis\"],\"suffixes\":[]}],\"month\":\"June\",\"year\":\"2019\",\"note\":\"Number: 6\",\"pages\":\"531–538\",\"bibtex\":\"@article{morales_combined_2019,\\n\\ttitle = {Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: {ISAAC} phase {III}},\\n\\tvolume = {74},\\n\\tissn = {0040-6376, 1468-3296},\\n\\tshorttitle = {Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children},\\n\\turl = {http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668},\\n\\tdoi = {10.1136/thoraxjnl-2018-212668},\\n\\tabstract = {Background\\n              Asthma is not the key focus of prevention strategies. A Healthy Lifestyle Index (HLI) was developed to examine the combined effect of modifiable lifestyle factors on asthma, rhinoconjunctivitis and eczema using data from the International Study of Asthma and Allergies in Childhood (ISAAC) phase III.\\n            \\n            \\n              Methods\\n              Information on symptoms of asthma, rhinoconjunctivitis, eczema and several lifestyle factors was obtained from children aged 6–7 years through written questionnaires. The HLI combined five lifestyle factors: no parental smoking, child’s adherence to Mediterranean diet, child’s healthy body mass index, high physical activity and non-sedentary behaviour. The association between the HLI and risk of asthma, rhinoconjunctivitis and eczema was evaluated using multilevel mixed-effects logistic regression models.\\n            \\n            \\n              Findings\\n              Data of 70 795 children from 37 centres in 19 countries were analysed. Each additional healthy lifestyle factor was associated with a reduced risk of current wheeze (OR 0.87, 95\\\\% CI 0.84 to 0.89), asthma ever (OR 0.89, 95\\\\% CI 0.87 to 0.92), current symptoms of rhinoconjunctivitis (OR 0.95, 95\\\\% CI 0.92 to 0.97) and current symptoms of eczema (OR 0.92, 95\\\\% CI 0.92 to 0.98). Theoretically, if associations were causal, a combination of four or five healthy lifestyle factors would result into a reduction up to 16\\\\% of asthma cases (ranging from 2.7\\\\% to 26.3 \\\\% according to region of the world).\\n            \\n            \\n              Conclusions\\n              These findings should be interpreted with caution given the limitations to infer causality from cross-sectional observational data. Efficacy of interventions to improve multiple modifiable lifestyle factors to reduce the burden asthma and allergy in childhood should be assessed.},\\n\\tlanguage = {en},\\n\\tnumber = {6},\\n\\turldate = {2020-08-23},\\n\\tjournal = {Thorax},\\n\\tauthor = {Morales, Eva and Strachan, David and Asher, Innes and Ellwood, Philippa and Pearce, Neil and Garcia-Marcos, Luis},\\n\\tmonth = jun,\\n\\tyear = {2019},\\n\\tnote = {Number: 6},\\n\\tpages = {531--538},\\n}\\n\\n\",\"author_short\":[\"Morales, E.\",\"Strachan, D.\",\"Asher, I.\",\"Ellwood, P.\",\"Pearce, N.\",\"Garcia-Marcos, L.\"],\"key\":\"morales_combined_2019\",\"id\":\"morales_combined_2019\",\"bibbaseid\":\"morales-strachan-asher-ellwood-pearce-garciamarcos-combinedimpactofhealthylifestylefactorsonriskofasthmarhinoconjunctivitisandeczemainschoolchildrenisaacphaseiii-2019\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial\",\"volume\":\"394\",\"issn\":\"01406736\",\"shorttitle\":\"Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL)\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488\",\"doi\":\"10.1016/S0140-6736(19)31948-8\",\"language\":\"en\",\"number\":\"10202\",\"urldate\":\"2020-08-23\",\"journal\":\"The Lancet\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Hardy\"],\"firstnames\":[\"Jo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Baggott\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harwood\"],\"firstnames\":[\"Matire\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Corin\"],\"firstnames\":[\"Andrew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sparks\"],\"firstnames\":[\"Jenny\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hall\"],\"firstnames\":[\"Daniela\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sabbagh\"],\"firstnames\":[\"Doñah\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Mane\"],\"firstnames\":[\"Saras\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vohlidkova\"],\"firstnames\":[\"Alexandra\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Martindale\"],\"firstnames\":[\"John\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shirtcliffe\"],\"firstnames\":[\"Philippa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Corin\"],\"firstnames\":[\"Andrew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Dronfield\"],\"firstnames\":[\"Liz\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Helm\"],\"firstnames\":[\"Colin\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Paterson\"],\"firstnames\":[\"Tracy\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Poudel\"],\"firstnames\":[\"Bhuwan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Dyer\"],\"firstnames\":[\"Malcolm\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Jasinski\"],\"firstnames\":[\"Christine\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sheahan\"],\"firstnames\":[\"Davitt\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sheahan\"],\"firstnames\":[\"Pamela\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gailer\"],\"firstnames\":[\"Nick\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Van\",\"Zuilen\"],\"firstnames\":[\"Jan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Basa\"],\"firstnames\":[\"Andy\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Devereaux\"],\"firstnames\":[\"Christine\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Egan\"],\"firstnames\":[\"Karin\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Haughey\"],\"firstnames\":[\"Sneha\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Marks\"],\"firstnames\":[\"Rodney\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Venter\"],\"firstnames\":[\"Dirk\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Zhang\"],\"firstnames\":[\"Hank\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trevithick\"],\"firstnames\":[\"Karen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mike\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Philippa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Baggott\"],\"firstnames\":[\"Christina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Eathorne\"],\"firstnames\":[\"Alexandra\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ebmeier\"],\"firstnames\":[\"Stefan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hall\"],\"firstnames\":[\"Daniela\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hardy\"],\"firstnames\":[\"Jo\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harwood\"],\"firstnames\":[\"Matire\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Houghton\"],\"firstnames\":[\"Claire\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Mane\"],\"firstnames\":[\"Saras\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Martindale\"],\"firstnames\":[\"John\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Oldfield\"],\"firstnames\":[\"Karen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pilcher\"],\"firstnames\":[\"Janine\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sabbagh\"],\"firstnames\":[\"Doñah\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shirtcliffe\"],\"firstnames\":[\"Philippa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Snively\"],\"firstnames\":[\"Suzanne\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sparks\"],\"firstnames\":[\"Jenny\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vohlidkova\"],\"firstnames\":[\"Alexandra\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Collins\"],\"firstnames\":[\"Patrick\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hassan\"],\"firstnames\":[\"Summer\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Lam\"],\"firstnames\":[\"Annika\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Lionnet\"],\"firstnames\":[\"Claudette\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Montgomery\"],\"firstnames\":[\"Barney\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Smaill\"],\"firstnames\":[\"Liz\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Moon\"],\"firstnames\":[\"Stella\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Quinn\"],\"firstnames\":[\"Dean\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bayly-McCredie\"],\"firstnames\":[\"Elena\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Millar-Coote\"],\"firstnames\":[\"Chris\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Millar-Coote\"],\"firstnames\":[\"Dean\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reid\"],\"firstnames\":[\"Jim\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Samuel\"],\"firstnames\":[\"Anna\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Burton\"],\"firstnames\":[\"Nicola\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Mullard\"],\"firstnames\":[\"Tina\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tranquilino\"],\"firstnames\":[\"Tyronne\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Watson\"],\"firstnames\":[\"Edward\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bell\"],\"firstnames\":[\"Jill\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harris\"],\"firstnames\":[\"Rachel\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Richmond\"],\"firstnames\":[\"John\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Smith\"],\"firstnames\":[\"Sue\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Krivan\"],\"firstnames\":[\"Brent\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Robertson\"],\"firstnames\":[\"Cheryl\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Glensor\"],\"firstnames\":[\"Sue\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"O'Connor\"],\"firstnames\":[\"Dermot\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Porrachia\"],\"firstnames\":[\"Anne-Christine\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K\"],\"suffixes\":[]}],\"month\":\"September\",\"year\":\"2019\",\"note\":\"Number: 10202\",\"pages\":\"919–928\",\"bibtex\":\"@article{hardy_budesonide-formoterol_2019,\\n\\ttitle = {Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma ({PRACTICAL}): a 52-week, open-label, multicentre, superiority, randomised controlled trial},\\n\\tvolume = {394},\\n\\tissn = {01406736},\\n\\tshorttitle = {Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma ({PRACTICAL})},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488},\\n\\tdoi = {10.1016/S0140-6736(19)31948-8},\\n\\tlanguage = {en},\\n\\tnumber = {10202},\\n\\turldate = {2020-08-23},\\n\\tjournal = {The Lancet},\\n\\tauthor = {Hardy, Jo and Baggott, Christina and Fingleton, James and Reddel, Helen K and Hancox, Robert J and Harwood, Matire and Corin, Andrew and Sparks, Jenny and Hall, Daniela and Sabbagh, Doñah and Mane, Saras and Vohlidkova, Alexandra and Martindale, John and Williams, Mathew and Shirtcliffe, Philippa and Holliday, Mark and Weatherall, Mark and Beasley, Richard and Corin, Andrew and Dronfield, Liz and Helm, Colin and Paterson, Tracy and Poudel, Bhuwan and Dyer, Malcolm and Jasinski, Christine and Sheahan, Davitt and Sheahan, Pamela and Gailer, Nick and Van Zuilen, Jan and Basa, Andy and Devereaux, Christine and Egan, Karin and Haughey, Sneha and Marks, Rodney and Venter, Dirk and Zhang, Hank and Trevithick, Karen and Williams, Mike and Williams, Philippa and Baggott, Christina and Beasley, Richard and Braithwaite, Irene and Eathorne, Alexandra and Ebmeier, Stefan and Fingleton, James and Hall, Daniela and Hardy, Jo and Harwood, Matire and Holliday, Mark and Houghton, Claire and Mane, Saras and Martindale, John and Oldfield, Karen and Pilcher, Janine and Sabbagh, Doñah and Shirtcliffe, Philippa and Snively, Suzanne and Sparks, Jenny and Vohlidkova, Alexandra and Williams, Mathew and Collins, Patrick and Hassan, Summer and Lam, Annika and Lionnet, Claudette and Montgomery, Barney and Smaill, Liz and Moon, Stella and Quinn, Dean and Bayly-McCredie, Elena and Millar-Coote, Chris and Millar-Coote, Dean and Reid, Jim and Samuel, Anna and Burton, Nicola and Mullard, Tina and Tranquilino, Tyronne and Watson, Edward and Bell, Jill and Harris, Rachel and Richmond, John and Smith, Sue and Krivan, Brent and Robertson, Cheryl and Hancox, Robert J and Weatherall, Mark and Glensor, Sue and O'Connor, Dermot and Porrachia, Anne-Christine and Reddel, Helen K},\\n\\tmonth = sep,\\n\\tyear = {2019},\\n\\tnote = {Number: 10202},\\n\\tpages = {919--928},\\n}\\n\\n\",\"author_short\":[\"Hardy, J.\",\"Baggott, C.\",\"Fingleton, J.\",\"Reddel, H. K\",\"Hancox, R. J\",\"Harwood, M.\",\"Corin, A.\",\"Sparks, J.\",\"Hall, D.\",\"Sabbagh, D.\",\"Mane, S.\",\"Vohlidkova, A.\",\"Martindale, J.\",\"Williams, M.\",\"Shirtcliffe, P.\",\"Holliday, M.\",\"Weatherall, M.\",\"Beasley, R.\",\"Corin, A.\",\"Dronfield, L.\",\"Helm, C.\",\"Paterson, T.\",\"Poudel, B.\",\"Dyer, M.\",\"Jasinski, C.\",\"Sheahan, D.\",\"Sheahan, P.\",\"Gailer, N.\",\"Van Zuilen, J.\",\"Basa, A.\",\"Devereaux, C.\",\"Egan, K.\",\"Haughey, S.\",\"Marks, R.\",\"Venter, D.\",\"Zhang, H.\",\"Trevithick, K.\",\"Williams, M.\",\"Williams, P.\",\"Baggott, C.\",\"Beasley, R.\",\"Braithwaite, I.\",\"Eathorne, A.\",\"Ebmeier, S.\",\"Fingleton, J.\",\"Hall, D.\",\"Hardy, J.\",\"Harwood, M.\",\"Holliday, M.\",\"Houghton, C.\",\"Mane, S.\",\"Martindale, J.\",\"Oldfield, K.\",\"Pilcher, J.\",\"Sabbagh, D.\",\"Shirtcliffe, P.\",\"Snively, S.\",\"Sparks, J.\",\"Vohlidkova, A.\",\"Williams, M.\",\"Collins, P.\",\"Hassan, S.\",\"Lam, A.\",\"Lionnet, C.\",\"Montgomery, B.\",\"Smaill, L.\",\"Moon, S.\",\"Quinn, D.\",\"Bayly-McCredie, E.\",\"Millar-Coote, C.\",\"Millar-Coote, D.\",\"Reid, J.\",\"Samuel, A.\",\"Burton, N.\",\"Mullard, T.\",\"Tranquilino, T.\",\"Watson, E.\",\"Bell, J.\",\"Harris, R.\",\"Richmond, J.\",\"Smith, S.\",\"Krivan, B.\",\"Robertson, C.\",\"Hancox, R. J\",\"Weatherall, M.\",\"Glensor, S.\",\"O'Connor, D.\",\"Porrachia, A.\",\"Reddel, H. K\"],\"key\":\"hardy_budesonide-formoterol_2019\",\"id\":\"hardy_budesonide-formoterol_2019\",\"bibbaseid\":\"hardy-baggott-fingleton-reddel-hancox-harwood-corin-sparks-etal-budesonideformoterolrelievertherapyversusmaintenancebudesonideplusterbutalinerelievertherapyinadultswithmildtomoderateasthmapracticala52weekopenlabelmulticentresuperiorityrandomisedcontrolledtrial-2019\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma\",\"volume\":\"7\",\"issn\":\"22132198\",\"shorttitle\":\"Severe Asthma Global Evaluation (SAGE)\",\"url\":\"https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X\",\"doi\":\"10.1016/j.jaip.2019.02.042\",\"language\":\"en\",\"number\":\"5\",\"urldate\":\"2020-08-23\",\"journal\":\"The Journal of Allergy and Clinical Immunology: In Practice\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Denton\"],\"firstnames\":[\"Eve\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hore-Lacy\"],\"firstnames\":[\"Fiona\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Radhakrishna\"],\"firstnames\":[\"Naghmeh\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gilbert\"],\"firstnames\":[\"Annie\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tay\"],\"firstnames\":[\"TunnRen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Lee\"],\"firstnames\":[\"Joy\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Dabscheck\"],\"firstnames\":[\"Eli\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harvey\"],\"firstnames\":[\"Erin\",\"S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bulathsinhala\"],\"firstnames\":[\"Lakmini\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Price\"],\"firstnames\":[\"David\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gibson\"],\"firstnames\":[\"Peter\",\"G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"O'Hehir\"],\"firstnames\":[\"Robyn\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hew\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]}],\"month\":\"May\",\"year\":\"2019\",\"note\":\"Number: 5\",\"pages\":\"1440–1449\",\"bibtex\":\"@article{denton_severe_2019,\\n\\ttitle = {Severe {Asthma} {Global} {Evaluation} ({SAGE}): {An} {Electronic} {Platform} for {Severe} {Asthma}},\\n\\tvolume = {7},\\n\\tissn = {22132198},\\n\\tshorttitle = {Severe {Asthma} {Global} {Evaluation} ({SAGE})},\\n\\turl = {https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X},\\n\\tdoi = {10.1016/j.jaip.2019.02.042},\\n\\tlanguage = {en},\\n\\tnumber = {5},\\n\\turldate = {2020-08-23},\\n\\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\\n\\tauthor = {Denton, Eve and Hore-Lacy, Fiona and Radhakrishna, Naghmeh and Gilbert, Annie and Tay, TunnRen and Lee, Joy and Dabscheck, Eli and Harvey, Erin S. and Bulathsinhala, Lakmini and Fingleton, James and Price, David and Gibson, Peter G. and O'Hehir, Robyn and Hew, Mark},\\n\\tmonth = may,\\n\\tyear = {2019},\\n\\tnote = {Number: 5},\\n\\tpages = {1440--1449},\\n}\\n\\n\",\"author_short\":[\"Denton, E.\",\"Hore-Lacy, F.\",\"Radhakrishna, N.\",\"Gilbert, A.\",\"Tay, T.\",\"Lee, J.\",\"Dabscheck, E.\",\"Harvey, E. S.\",\"Bulathsinhala, L.\",\"Fingleton, J.\",\"Price, D.\",\"Gibson, P. G.\",\"O'Hehir, R.\",\"Hew, M.\"],\"key\":\"denton_severe_2019\",\"id\":\"denton_severe_2019\",\"bibbaseid\":\"denton-horelacy-radhakrishna-gilbert-tay-lee-dabscheck-harvey-etal-severeasthmaglobalevaluationsageanelectronicplatformforsevereasthma-2019\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Nasal gene expression changes with inhaled corticosteroid treatment in asthma\",\"volume\":\"75\",\"issn\":\"1398-9995\",\"doi\":\"10.1111/all.13952\",\"language\":\"eng\",\"number\":\"1\",\"journal\":\"Allergy\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Boudewijn\"],\"firstnames\":[\"Ilse\",\"M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Lan\"],\"firstnames\":[\"Andy\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Faiz\"],\"firstnames\":[\"Alen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Cox\"],\"firstnames\":[\"Claire\",\"A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Brouwer\"],\"firstnames\":[\"Sharon\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Schokker\"],\"firstnames\":[\"Siebrig\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vroegop\"],\"firstnames\":[\"Sebastiaan\",\"J.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Nawijn\"],\"firstnames\":[\"Martijn\",\"C.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Woodruff\"],\"firstnames\":[\"Prescott\",\"G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Christenson\"],\"firstnames\":[\"Stephanie\",\"A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hagedoorn\"],\"firstnames\":[\"Paul\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Frijlink\"],\"firstnames\":[\"Henderik\",\"W.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Choy\"],\"firstnames\":[\"David\",\"F.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Brouwer\"],\"firstnames\":[\"Uilke\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Wisman\"],\"firstnames\":[\"Marissa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Postma\"],\"firstnames\":[\"Dirkje\",\"S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fingleton\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[\"van\",\"den\"],\"lastnames\":[\"Berge\"],\"firstnames\":[\"Maarten\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Guryev\"],\"firstnames\":[\"Victor\"],\"suffixes\":[]}],\"year\":\"2020\",\"pmid\":\"31230369\",\"note\":\"Number: 1\",\"pages\":\"191–194\",\"bibtex\":\"@article{boudewijn_nasal_2020,\\n\\ttitle = {Nasal gene expression changes with inhaled corticosteroid treatment in asthma},\\n\\tvolume = {75},\\n\\tissn = {1398-9995},\\n\\tdoi = {10.1111/all.13952},\\n\\tlanguage = {eng},\\n\\tnumber = {1},\\n\\tjournal = {Allergy},\\n\\tauthor = {Boudewijn, Ilse M. and Lan, Andy and Faiz, Alen and Cox, Claire A. and Brouwer, Sharon and Schokker, Siebrig and Vroegop, Sebastiaan J. and Nawijn, Martijn C. and Woodruff, Prescott G. and Christenson, Stephanie A. and Hagedoorn, Paul and Frijlink, Henderik W. and Choy, David F. and Brouwer, Uilke and Wisman, Marissa and Postma, Dirkje S. and Fingleton, James and Beasley, Richard and van den Berge, Maarten and Guryev, Victor},\\n\\tyear = {2020},\\n\\tpmid = {31230369},\\n\\tnote = {Number: 1},\\n\\tpages = {191--194},\\n}\\n\\n\",\"author_short\":[\"Boudewijn, I. M.\",\"Lan, A.\",\"Faiz, A.\",\"Cox, C. A.\",\"Brouwer, S.\",\"Schokker, S.\",\"Vroegop, S. J.\",\"Nawijn, M. C.\",\"Woodruff, P. G.\",\"Christenson, S. A.\",\"Hagedoorn, P.\",\"Frijlink, H. W.\",\"Choy, D. F.\",\"Brouwer, U.\",\"Wisman, M.\",\"Postma, D. S.\",\"Fingleton, J.\",\"Beasley, R.\",\"van den Berge, M.\",\"Guryev, V.\"],\"key\":\"boudewijn_nasal_2020\",\"id\":\"boudewijn_nasal_2020\",\"bibbaseid\":\"boudewijn-lan-faiz-cox-brouwer-schokker-vroegop-nawijn-etal-nasalgeneexpressionchangeswithinhaledcorticosteroidtreatmentinasthma-2020\",\"role\":\"author\",\"urls\":{},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Dose-response relationship of ICS/fast-onset LABA as reliever therapy in asthma\",\"volume\":\"19\",\"issn\":\"1471-2466\",\"url\":\"https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4\",\"doi\":\"10.1186/s12890-019-1014-4\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2020-08-23\",\"journal\":\"BMC Pulmonary Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harper\"],\"firstnames\":[\"James\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bird\"],\"firstnames\":[\"Grace\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Dunphy\"],\"firstnames\":[\"Harriette\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Semprini\"],\"firstnames\":[\"Alex\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\",\"D.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Papi\"],\"firstnames\":[\"Alberto\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]}],\"month\":\"December\",\"year\":\"2019\",\"note\":\"Number: 1\",\"pages\":\"264\",\"bibtex\":\"@article{beasley_dose-response_2019,\\n\\ttitle = {Dose-response relationship of {ICS}/fast-onset {LABA} as reliever therapy in asthma},\\n\\tvolume = {19},\\n\\tissn = {1471-2466},\\n\\turl = {https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4},\\n\\tdoi = {10.1186/s12890-019-1014-4},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2020-08-23},\\n\\tjournal = {BMC Pulmonary Medicine},\\n\\tauthor = {Beasley, Richard and Harper, James and Bird, Grace and Dunphy, Harriette and Semprini, Alex and Pavord, Ian D. and Papi, Alberto and Weatherall, Mark},\\n\\tmonth = dec,\\n\\tyear = {2019},\\n\\tnote = {Number: 1},\\n\\tpages = {264},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Harper, J.\",\"Bird, G.\",\"Dunphy, H.\",\"Semprini, A.\",\"Pavord, I. D.\",\"Papi, A.\",\"Weatherall, M.\"],\"key\":\"beasley_dose-response_2019\",\"id\":\"beasley_dose-response_2019\",\"bibbaseid\":\"beasley-harper-bird-dunphy-semprini-pavord-papi-weatherall-doseresponserelationshipoficsfastonsetlabaasrelievertherapyinasthma-2019\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma\",\"volume\":\"380\",\"issn\":\"0028-4793, 1533-4406\",\"url\":\"http://www.nejm.org/doi/10.1056/NEJMoa1901963\",\"doi\":\"10.1056/NEJMoa1901963\",\"language\":\"en\",\"number\":\"21\",\"urldate\":\"2020-08-23\",\"journal\":\"New England Journal of Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\",\"K.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ebmeier\"],\"firstnames\":[\"Stefan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harrison\"],\"firstnames\":[\"Tim\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Houghton\"],\"firstnames\":[\"Claire\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Oldfield\"],\"firstnames\":[\"Karen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Papi\"],\"firstnames\":[\"Alberto\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\",\"D.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]}],\"month\":\"May\",\"year\":\"2019\",\"note\":\"Number: 21\",\"pages\":\"2020–2030\",\"bibtex\":\"@article{beasley_controlled_2019,\\n\\ttitle = {Controlled {Trial} of {Budesonide}–{Formoterol} as {Needed} for {Mild} {Asthma}},\\n\\tvolume = {380},\\n\\tissn = {0028-4793, 1533-4406},\\n\\turl = {http://www.nejm.org/doi/10.1056/NEJMoa1901963},\\n\\tdoi = {10.1056/NEJMoa1901963},\\n\\tlanguage = {en},\\n\\tnumber = {21},\\n\\turldate = {2020-08-23},\\n\\tjournal = {New England Journal of Medicine},\\n\\tauthor = {Beasley, Richard and Holliday, Mark and Reddel, Helen K. and Braithwaite, Irene and Ebmeier, Stefan and Hancox, Robert J. and Harrison, Tim and Houghton, Claire and Oldfield, Karen and Papi, Alberto and Pavord, Ian D. and Williams, Mathew and Weatherall, Mark},\\n\\tmonth = may,\\n\\tyear = {2019},\\n\\tnote = {Number: 21},\\n\\tpages = {2020--2030},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Holliday, M.\",\"Reddel, H. K.\",\"Braithwaite, I.\",\"Ebmeier, S.\",\"Hancox, R. J.\",\"Harrison, T.\",\"Houghton, C.\",\"Oldfield, K.\",\"Papi, A.\",\"Pavord, I. D.\",\"Williams, M.\",\"Weatherall, M.\"],\"key\":\"beasley_controlled_2019\",\"id\":\"beasley_controlled_2019\",\"bibbaseid\":\"beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-controlledtrialofbudesonideformoterolasneededformildasthma-2019\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://www.nejm.org/doi/10.1056/NEJMoa1901963\"},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Trial of an asthma action plan in the Maori community of the Wairarapa\",\"volume\":\"106\",\"issn\":\"0028-8446\",\"abstract\":\"AIMS: An asthma action plan has been tested in a study conducted by Wairarapa Maori community health workers and the Wellington asthma research group. There were several distinctive features of the project, including the programme of marae-based asthma clinics, and the partnership between the researchers and the Maori community groups. This paper describes the process by which the study was conducted since this experience may be relevant to future Maori health research projects. METHODS: The programme was launched with a series of hui at marae in the Wairarapa, and marae-based clinics were set up. These were followed up by further support from the Maori community health workers who helped people to keep diaries to monitor their asthma, and generally maintained contact. The severity of asthma in the participants was compared for a two-month period before the action plan was introduced, and for a four-month period after the plan was introduced. RESULTS: There was a high participation rate, with 91% (63/69) of participants finishing the programme, 75% of whom adequately completed their daily asthma diaries. Asthma control improved significantly in the participants. They commented positively on the programme, and particularly on the marae-based clinics. CONCLUSIONS: The study was successful in terms of participation in the marae-based clinics, acceptance and use of the plan, and improvement in asthma control of the participants. The findings indicate what can be achieved when researchers and Maori community groups work in partnership.\",\"language\":\"eng\",\"number\":\"961\",\"journal\":\"The New Zealand Medical Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"D'Souza\"],\"firstnames\":[\"W.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Te\",\"Karu\"],\"firstnames\":[\"H.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fox\"],\"firstnames\":[\"C.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harper\"],\"firstnames\":[\"M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Robson\"],\"firstnames\":[\"B.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Howden-Chapman\"],\"firstnames\":[\"P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Crane\"],\"firstnames\":[\"J.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Burgess\"],\"firstnames\":[\"C.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Woodman\"],\"firstnames\":[\"K.\"],\"suffixes\":[]}],\"month\":\"August\",\"year\":\"1993\",\"pmid\":\"8341475\",\"note\":\"Number: 961\",\"keywords\":\"Asthma, Community Health Workers, European Continental Ancestry Group, Humans, New Zealand, Oceanic Ancestry Group, Patient Acceptance of Health Care, Patient Education as Topic, Program Evaluation\",\"pages\":\"336–338\",\"bibtex\":\"@article{beasley_trial_1993,\\n\\ttitle = {Trial of an asthma action plan in the {Maori} community of the {Wairarapa}},\\n\\tvolume = {106},\\n\\tissn = {0028-8446},\\n\\tabstract = {AIMS: An asthma action plan has been tested in a study conducted by Wairarapa Maori community health workers and the Wellington asthma research group. There were several distinctive features of the project, including the programme of marae-based asthma clinics, and the partnership between the researchers and the Maori community groups. This paper describes the process by which the study was conducted since this experience may be relevant to future Maori health research projects.\\nMETHODS: The programme was launched with a series of hui at marae in the Wairarapa, and marae-based clinics were set up. These were followed up by further support from the Maori community health workers who helped people to keep diaries to monitor their asthma, and generally maintained contact. The severity of asthma in the participants was compared for a two-month period before the action plan was introduced, and for a four-month period after the plan was introduced.\\nRESULTS: There was a high participation rate, with 91\\\\% (63/69) of participants finishing the programme, 75\\\\% of whom adequately completed their daily asthma diaries. Asthma control improved significantly in the participants. They commented positively on the programme, and particularly on the marae-based clinics.\\nCONCLUSIONS: The study was successful in terms of participation in the marae-based clinics, acceptance and use of the plan, and improvement in asthma control of the participants. The findings indicate what can be achieved when researchers and Maori community groups work in partnership.},\\n\\tlanguage = {eng},\\n\\tnumber = {961},\\n\\tjournal = {The New Zealand Medical Journal},\\n\\tauthor = {Beasley, R. and D'Souza, W. and Te Karu, H. and Fox, C. and Harper, M. and Robson, B. and Howden-Chapman, P. and Crane, J. and Burgess, C. and Woodman, K.},\\n\\tmonth = aug,\\n\\tyear = {1993},\\n\\tpmid = {8341475},\\n\\tnote = {Number: 961},\\n\\tkeywords = {Asthma, Community Health Workers, European Continental Ancestry Group, Humans, New Zealand, Oceanic Ancestry Group, Patient Acceptance of Health Care, Patient Education as Topic, Program Evaluation},\\n\\tpages = {336--338},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"D'Souza, W.\",\"Te Karu, H.\",\"Fox, C.\",\"Harper, M.\",\"Robson, B.\",\"Howden-Chapman, P.\",\"Crane, J.\",\"Burgess, C.\",\"Woodman, K.\"],\"key\":\"beasley_trial_1993\",\"id\":\"beasley_trial_1993\",\"bibbaseid\":\"beasley-dsouza-tekaru-fox-harper-robson-howdenchapman-crane-etal-trialofanasthmaactionplaninthemaoricommunityofthewairarapa-1993\",\"role\":\"author\",\"urls\":{},\"keyword\":[\"Asthma\",\"Community Health Workers\",\"European Continental Ancestry Group\",\"Humans\",\"New Zealand\",\"Oceanic Ancestry Group\",\"Patient Acceptance of Health Care\",\"Patient Education as Topic\",\"Program Evaluation\"],\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Asthma morbidity 6 yrs after an effective asthma self-management programme in a Maori community\",\"volume\":\"15\",\"issn\":\"0903-1936, 1399-3003\",\"url\":\"http://erj.ersjournals.com/content/15/3/464\",\"doi\":\"10.1034/j.1399-3003.2000.15.07.x\",\"language\":\"en\",\"number\":\"3\",\"urldate\":\"2020-07-13\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"D'souza\"],\"firstnames\":[\"W.j\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Slater\"],\"firstnames\":[\"T\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fox\"],\"firstnames\":[\"C\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fox\"],\"firstnames\":[\"B\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Te\",\"Karu\"],\"firstnames\":[\"H\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gemmell\"],\"firstnames\":[\"T\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ratima\"],\"firstnames\":[\"M.m\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pearce\"],\"firstnames\":[\"N.e\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"R.b\"],\"suffixes\":[]}],\"month\":\"March\",\"year\":\"2000\",\"note\":\"Number: 3\",\"pages\":\"464–469\",\"bibtex\":\"@article{dsouza_asthma_2000,\\n\\ttitle = {Asthma morbidity 6 yrs 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= {Randomized {Controlled} {Trial} {Of} {Asthma} {Risk} {With} {Paracetamol} {Use} {In} {Infancy} - {A} {Feasibility} {Study}.},\\n\\tvolume = {45},\\n\\tdoi = {10.1111/cea.12433},\\n\\tjournal = {Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},\\n\\tauthor = {Riley, Judith and Braithwaite, Irene and Shirtcliffe, Philippa and Caswell-Smith, Rachel and Hunt, Anna and Bowden, Vanessa and Power, Sharon and Stanley, Thorsten and Crane, Julian and Ingham, Tristram and Weatherall, Mark and Mitchell, Edwin and Beasley, Richard},\\n\\tyear = {2014},\\n}\\n\\n\",\"author_short\":[\"Riley, J.\",\"Braithwaite, I.\",\"Shirtcliffe, P.\",\"Caswell-Smith, R.\",\"Hunt, A.\",\"Bowden, V.\",\"Power, S.\",\"Stanley, T.\",\"Crane, J.\",\"Ingham, T.\",\"Weatherall, M.\",\"Mitchell, E.\",\"Beasley, 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Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Power\"],\"firstnames\":[\"Sharon\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pilcher\"],\"firstnames\":[\"Janine\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Baines\"],\"firstnames\":[\"Amanda\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Moynihan\"],\"firstnames\":[\"Jackie\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kempsford\"],\"firstnames\":[\"Rodger\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"year\":\"2016\",\"pages\":\"115–121\",\"bibtex\":\"@article{braithwaite_randomised_2016,\\n\\ttitle = {Randomised, double-blind, placebo-controlled, cross-over single dose study of the bronchodilator duration of action of combination fluticasone furoate/vilanterol inhaler in adult asthma},\\n\\tvolume = {119},\\n\\tdoi = {10.1016/j.rmed.2016.09.006},\\n\\tjournal = {Respiratory Medicine},\\n\\tauthor = {Braithwaite, Irene and Williams, Mathew and Power, Sharon and Pilcher, Janine and Weatherall, Mark and Baines, Amanda and Moynihan, Jackie and Kempsford, Rodger and Beasley, Richard},\\n\\tyear = {2016},\\n\\tpages = {115--121},\\n}\\n\\n\",\"author_short\":[\"Braithwaite, I.\",\"Williams, M.\",\"Power, S.\",\"Pilcher, J.\",\"Weatherall, M.\",\"Baines, A.\",\"Moynihan, J.\",\"Kempsford, R.\",\"Beasley, R.\"],\"key\":\"braithwaite_randomised_2016\",\"id\":\"braithwaite_randomised_2016\",\"bibbaseid\":\"braithwaite-williams-power-pilcher-weatherall-baines-moynihan-kempsford-etal-randomiseddoubleblindplacebocontrolledcrossoversingledosestudyofthebronchodilatordurationofactionofcombinationfluticasonefuroatevilanterolinhalerinadultasthma-2016\",\"role\":\"author\",\"urls\":{},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults\",\"volume\":\"4\",\"doi\":\"10.1136/bmjopen-2013-004324\",\"journal\":\"BMJ open\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Ioannides\"],\"firstnames\":[\"Sally\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Jefferies\"],\"firstnames\":[\"Sarah\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Perrin\"],\"firstnames\":[\"Kyle\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Siebers\"],\"firstnames\":[\"Robert\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Crane\"],\"firstnames\":[\"Julian\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Patel\"],\"firstnames\":[\"Mitesh\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Travers\"],\"firstnames\":[\"Justin\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shirtcliffe\"],\"firstnames\":[\"Philippa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"year\":\"2014\",\"pages\":\"e004324\",\"bibtex\":\"@article{ioannides_randomised_2014,\\n\\ttitle = {Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults},\\n\\tvolume = {4},\\n\\tdoi = {10.1136/bmjopen-2013-004324},\\n\\tjournal = {BMJ open},\\n\\tauthor = {Ioannides, Sally and Williams, Mathew and Jefferies, Sarah and Perrin, Kyle and Weatherall, Mark and Siebers, Robert and Crane, Julian and Patel, Mitesh and Travers, Justin and Shirtcliffe, Philippa and Beasley, Richard},\\n\\tyear = {2014},\\n\\tpages = {e004324},\\n}\\n\\n\",\"author_short\":[\"Ioannides, S.\",\"Williams, M.\",\"Jefferies, S.\",\"Perrin, K.\",\"Weatherall, M.\",\"Siebers, R.\",\"Crane, J.\",\"Patel, M.\",\"Travers, J.\",\"Shirtcliffe, P.\",\"Beasley, R.\"],\"key\":\"ioannides_randomised_2014\",\"id\":\"ioannides_randomised_2014\",\"bibbaseid\":\"ioannides-williams-jefferies-perrin-weatherall-siebers-crane-patel-etal-randomisedplacebocontrolledstudyoftheeffectofparacetamolonasthmaseverityinadults-2014\",\"role\":\"author\",\"urls\":{},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma\",\"volume\":\"66\",\"doi\":\"10.1136/thx.2010.155259\",\"journal\":\"Thorax\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Perrin\"],\"firstnames\":[\"Kyle\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Wijesinghe\"],\"firstnames\":[\"Meme\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Healy\"],\"firstnames\":[\"Bridget\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Wadsworth\"],\"firstnames\":[\"Kirsten\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bowditch\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bibby\"],\"firstnames\":[\"Susan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Baker\"],\"firstnames\":[\"Tanya\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"year\":\"2011\",\"pages\":\"937–941\",\"bibtex\":\"@article{perrin_randomised_2011,\\n\\ttitle = {Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma},\\n\\tvolume = {66},\\n\\tdoi = {10.1136/thx.2010.155259},\\n\\tjournal = {Thorax},\\n\\tauthor = {Perrin, Kyle and Wijesinghe, Meme and Healy, Bridget and Wadsworth, Kirsten and Bowditch, Richard and Bibby, Susan and Baker, Tanya and Weatherall, Mark and Beasley, Richard},\\n\\tyear = {2011},\\n\\tpages = {937--941},\\n}\\n\\n\",\"author_short\":[\"Perrin, K.\",\"Wijesinghe, M.\",\"Healy, B.\",\"Wadsworth, K.\",\"Bowditch, R.\",\"Bibby, S.\",\"Baker, T.\",\"Weatherall, M.\",\"Beasley, R.\"],\"key\":\"perrin_randomised_2011\",\"id\":\"perrin_randomised_2011\",\"bibbaseid\":\"perrin-wijesinghe-healy-wadsworth-bowditch-bibby-baker-weatherall-etal-randomisedcontrolledtrialofhighconcentrationversustitratedoxygentherapyinsevereexacerbationsofasthma-2011\",\"role\":\"author\",\"urls\":{},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Predictors of Severe Exacerbations, Poor Asthma Control, and β-Agonist Overuse in Asthma for Patients with Asthma\",\"volume\":\"2\",\"doi\":\"10.1016/j.jaip.2014.06.001\",\"journal\":\"The Journal of Allergy and Clinical Immunology: In Practice\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Patel\"],\"firstnames\":[\"Mitesh\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pilcher\"],\"firstnames\":[\"Janine\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Qi\"],\"firstnames\":[\"Victoria\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Mackey\"],\"firstnames\":[\"Bill\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tranquilino\"],\"firstnames\":[\"Tyronne\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shaw\"],\"firstnames\":[\"Dominick\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Black\"],\"firstnames\":[\"Peter\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"year\":\"2014\",\"bibtex\":\"@article{patel_predictors_2014,\\n\\ttitle = {Predictors of {Severe} {Exacerbations}, {Poor} {Asthma} {Control}, and β-{Agonist} {Overuse} in {Asthma} for {Patients} with {Asthma}},\\n\\tvolume = {2},\\n\\tdoi = {10.1016/j.jaip.2014.06.001},\\n\\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\\n\\tauthor = {Patel, Mitesh and Pilcher, Janine and Reddel, Helen and Qi, Victoria and Mackey, Bill and Tranquilino, Tyronne and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard},\\n\\tyear = {2014},\\n}\\n\\n\",\"author_short\":[\"Patel, M.\",\"Pilcher, J.\",\"Reddel, H.\",\"Qi, V.\",\"Mackey, B.\",\"Tranquilino, T.\",\"Shaw, D.\",\"Black, P.\",\"Weatherall, M.\",\"Beasley, R.\"],\"key\":\"patel_predictors_2014\",\"id\":\"patel_predictors_2014\",\"bibbaseid\":\"patel-pilcher-reddel-qi-mackey-tranquilino-shaw-black-etal-predictorsofsevereexacerbationspoorasthmacontrolandagonistoveruseinasthmaforpatientswithasthma-2014\",\"role\":\"author\",\"urls\":{},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy\",\"volume\":\"129\",\"journal\":\"The New Zealand medical journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Riley\"],\"firstnames\":[\"Judith\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hunt\"],\"firstnames\":[\"Anna\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"McDouall\"],\"firstnames\":[\"Alice\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Waqanivavalagi\"],\"firstnames\":[\"Steve\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Stanley\"],\"firstnames\":[\"Thorsten\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Mitchell\"],\"firstnames\":[\"Edwin\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"R\",\"Dalziel\"],\"firstnames\":[\"Stuart\"],\"suffixes\":[]}],\"year\":\"2016\",\"pages\":\"30–42\",\"bibtex\":\"@article{riley_pilot_2016,\\n\\ttitle = {Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy},\\n\\tvolume = {129},\\n\\tjournal = {The New Zealand medical journal},\\n\\tauthor = {Riley, Judith and Hunt, Anna and McDouall, Alice and Waqanivavalagi, Steve and Braithwaite, Irene and Weatherall, Mark and Stanley, Thorsten and Beasley, Richard and Mitchell, Edwin and R Dalziel, Stuart},\\n\\tyear = {2016},\\n\\tpages = {30--42},\\n}\\n\\n\",\"author_short\":[\"Riley, J.\",\"Hunt, A.\",\"McDouall, A.\",\"Waqanivavalagi, S.\",\"Braithwaite, I.\",\"Weatherall, M.\",\"Stanley, T.\",\"Beasley, R.\",\"Mitchell, E.\",\"R Dalziel, S.\"],\"key\":\"riley_pilot_2016\",\"id\":\"riley_pilot_2016\",\"bibbaseid\":\"riley-hunt-mcdouall-waqanivavalagi-braithwaite-weatherall-stanley-beasley-etal-pilotstudyoffeasibilityofarandomisedcontrolledtrialofasthmariskwithparacetamolversusibuprofenuseininfancy-2016\",\"role\":\"author\",\"urls\":{},\"metadata\":{\"authorlinks\":{\"beasley, r\":\"https://www.mrinz.ac.nz/\"}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"New Zealand asthma guidelines updated\",\"volume\":\"130\",\"issn\":\"1175-8716\",\"number\":\"1466\",\"journal\":\"The New Zealand Medical Journal (Online)\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hancox\"],\"firstnames\":[\"Robert\",\"J\"],\"suffixes\":[]}],\"year\":\"2017\",\"note\":\"Number: 1466 Publisher: New Zealand Medical Association (NZMA)\",\"pages\":\"7–9\",\"bibtex\":\"@article{beasley_new_2017,\\n\\ttitle = {New {Zealand} asthma guidelines updated},\\n\\tvolume = {130},\\n\\tissn = {1175-8716},\\n\\tnumber = {1466},\\n\\tjournal = {The New Zealand Medical Journal (Online)},\\n\\tauthor = {Beasley, Richard and Hancox, Robert J},\\n\\tyear = {2017},\\n\\tnote = {Number: 1466\\nPublisher: New Zealand Medical Association (NZMA)},\\n\\tpages = {7--9},\\n}\\n\",\"author_short\":[\"Beasley, R.\",\"Hancox, R. J\"],\"key\":\"beasley_new_2017\",\"id\":\"beasley_new_2017\",\"bibbaseid\":\"beasley-hancox-newzealandasthmaguidelinesupdated-2017\",\"role\":\"author\",\"urls\":{},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"}],\n      metadata: {\"authorlinks\":{}},\n      ownerID: undefined\n    };\n  </script>\n\n  <script type=\"text/javascript\">\n  var site$;\n  if (typeof $ != 'undefined') {\n    console.log('existing jquery: storing and then restoring');\n    site$ = $;\n    $ = null;\n  }\n  </script>\n\n  <script src=\"https://ajax.googleapis.com/ajax/libs/jquery/2.2.4/jquery.min.js\">\n  </script>\n  <script type=\"text/javascript\">\n  if (site$) {\n    console.log('existing jquery: avoiding conflict and restoring');\n    bb$ = $.noConflict(true);\n    $ = site$;\n  } else {\n    bb$ = $;\n  }\n  </script>\n\n  <script src=\"//bibbase.org/js/bibbase.min.js\"\n          type=\"text/javascript\">\n  </script>\n\n  <script type=\"text/javascript\"\n          src=\"https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.1/MathJax.js?config=TeX-AMS-MML_HTMLorMML\">\n  </script>\n  <script type=\"text/x-mathjax-config\">\n    MathJax.Hub.Config({tex2jax: {inlineMath: [['$','$'], ['\\\\(','\\\\)']]},\n                        skipTags: [\"body\"],\n                        processClass: \"bibbase_paper\"});\n  </script>\n\n  <style>\n  @media print {\n    .dontprint {\n        display: none !important;\n    }\n\n  .bibbase_group {\n    background-color: #E0E0E0;\n    font-style: italic;\n    font-size: larger;\n    text-shadow: 0px 0px 3px #FFFFFF;\n    border-radius: 4px 4px 4px 4px;\n    -moz-border-radius: 4px 4px 4px 4px;\n    -webkit-border-radius: 4px;\n    padding: 5px 40px 5px;\n    margin-top: 10px;\n    margin-bottom: 5px;\n    cursor: pointer;\n  }\n\n  .bibbase_paper {\n    margin-bottom: 5px;\n  }\n\n  }\n  </style>\n\n  \n  <div style=\"float: right; margin-right: 10px; margin-top: 10px; text-align: right; font-size: 12px\">\n    generated by\n    <a href=\"//bibbase.org\"\n       onclick=\"trackOutboundLink('bibbase', 'logo clicked', window.location.href, '//bibbase.org'); return false;\">\n      <img src=\"//bibbase.org/img/logo.svg\"\n           style=\"vertical-align: middle; margin-left: 3px; height: 16px;\"/\n           alt=\"bibbase.org\"\n           title=\"BibBase – The easiest way to maintain your publications page.\"\n        ></a>\n    \n  </div>\n  \n\n  <div id=\"bibbase_header\" class=\"dontprint\" style=\"\">\n\n    <ul class=\"nav nav-pills\" style=\"margin: 0px;\">\n\n      <li class=\"dropdown\" id=\"groupby_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\">\n          Group by\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li class=\"groupby year\"><a onclick=\"groupby('year')\">\n            Year</a>\n        </li>\n        <li class=\"groupby author\"><a onclick=\"groupby('author_short')\">\n            Author</a>\n        </li>\n        <li class=\"groupby type\"><a onclick=\"groupby('type')\">\n            Type</a>\n        </li>\n        <li class=\"groupby keyword\"><a onclick=\"groupby('keyword')\">\n            Keyword</a>\n        </li>\n        <li class=\"groupby downloads\"><a onclick=\"groupby('downloads')\">\n            Downloads</a>\n        </li>\n      </ul>\n      </li>\n\n\n      <li class=\"dropdown\" id=\"menu_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\" alt=\"controls\">\n          <i class=\"fa fa-reorder\" alt=\"controls\"></i>\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li>\n          <a onclick=\"toggleAll()\">\n            <i class=\"fa fa-chevron-down fa-fw\"></i> Expand/Collapse All\n          </a>\n        </li>\n        <li>\n          <a download=\"items\" href=\"data:text/bibtex;base64,@article{rogliani_smart_2021,
	title = {{SMART} for the treatment of asthma: {A} network meta-analysis of real-world evidence},
	volume = {188},
	issn = {09546111},
	shorttitle = {{SMART} for the treatment of asthma},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X},
	doi = {10.1016/j.rmed.2021.106611},
	language = {en},
	urldate = {2022-03-27},
	journal = {Respiratory Medicine},
	author = {Rogliani, Paola and Beasley, Richard and Cazzola, Mario and Calzetta, Luigino},
	month = nov,
	year = {2021},
	pages = {106611},
}



@article{ali_enhanced_2021,
	title = {Enhanced airway sensory nerve reactivity in non-eosinophilic asthma},
	volume = {8},
	issn = {2052-4439},
	url = {https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974},
	doi = {10.1136/bmjresp-2021-000974},
	abstract = {Background
              Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics.
            
            
              Methods
              
                Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5\%. Airway hyperreactivity was defined as a ≥15\% drop in FEV
                1
                during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs.
              
            
            
              Results
              
                Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95\% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p{\textless}0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV
                1
                was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed.
              
            
            
              Conclusion
              NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.},
	language = {en},
	number = {1},
	urldate = {2022-03-27},
	journal = {BMJ Open Respiratory Research},
	author = {Ali, Hajar and Brooks, Collin and Crane, Julian and Beasley, Richard and Holgate, Stephen and Gibson, Peter and Pattemore, Philip and Tzeng, Yu-Chieh and Stanley, Thorsten and Pearce, Neil and Douwes, Jeroen},
	month = nov,
	year = {2021},
	pages = {e000974},
}



@article{baggott_asthma_2021,
	title = {Asthma in the anti-inflammatory reliever therapy era},
	volume = {9},
	issn = {22132600},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653},
	doi = {10.1016/S2213-2600(20)30465-3},
	language = {en},
	number = {2},
	urldate = {2022-03-27},
	journal = {The Lancet Respiratory Medicine},
	author = {Baggott, Christina and Beasley, Richard},
	month = feb,
	year = {2021},
	pages = {118--119},
}



@article{foster_perspectives_2022,
	title = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study},
	volume = {12},
	issn = {2044-6055, 2044-6055},
	shorttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens},
	url = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537},
	doi = {10.1136/bmjopen-2020-048537},
	abstract = {Objectives
              As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens.
            
            
              Setting
              A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment.
            
            
              Participants
              Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings.
            
            
              Results
              Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it.
            
            
              Conclusions
              Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation.
            
            
              Trial registration number
              ACTRN12615000999538.},
	language = {en},
	number = {1},
	urldate = {2022-03-27},
	journal = {BMJ Open},
	author = {Foster, Juliet and Beasley, Richard and Braithwaite, Irene and Harrison, Tim and Holliday, Mark and Pavord, Ian and Reddel, Helen},
	month = jan,
	year = {2022},
	pages = {e048537},
}



@article{couillard_predicting_2022,
	title = {Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype {Oxford} {Asthma} {Attack} {Risk} {Scale} ({ORACLE})},
	volume = {8},
	issn = {2312-0541},
	url = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021},
	doi = {10.1183/23120541.00570-2021},
	language = {en},
	number = {1},
	urldate = {2022-03-27},
	journal = {ERJ Open Research},
	author = {Couillard, Simon and Do, William Il Hoon and Beasley, Richard and Hinks, Timothy S.C. and Pavord, Ian D.},
	month = jan,
	year = {2022},
	pages = {00570--2021},
}



@article{beasley_evaluation_2022,
	title = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}: {A} {Systematic} {Review} and {Meta}-analysis},
	volume = {5},
	issn = {2574-3805},
	shorttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}},
	url = {https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512},
	doi = {10.1001/jamanetworkopen.2022.0615},
	language = {en},
	number = {3},
	urldate = {2022-03-04},
	journal = {JAMA Network Open},
	author = {Beasley, Richard and Harrison, Tim and Peterson, Stefan and Gustafson, Per and Hamblin, Angus and Bengtsson, Thomas and Fagerås, Malin},
	month = mar,
	year = {2022},
	pages = {e220615},
}



@article{beasley_asthma_2021,
	title = {Asthma and {COVID}-19: {Preconceptions} about {Predisposition}},
	volume = {203},
	issn = {1073-449X, 1535-4970},
	shorttitle = {Asthma and {COVID}-19},
	url = {https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED},
	doi = {10.1164/rccm.202102-0266ED},
	language = {en},
	number = {7},
	urldate = {2022-03-04},
	journal = {American Journal of Respiratory and Critical Care Medicine},
	author = {Beasley, Richard and Hills, Thomas and Kearns, Nethmi},
	month = apr,
	year = {2021},
	pages = {799--801},
}



@article{kearns_repeated_2022,
	title = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: {A} randomised cross-over trial},
	issn = {0903-1936, 1399-3003},
	shorttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021},
	doi = {10.1183/13993003.02309-2021},
	abstract = {Objective
              
                To determine the comparative bronchodilator, systemic beta
                2
                -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma.
              
            
            
              Methods
              
                This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg
                via
                MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg
                via
                nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation
                via
                Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV
                1
                after 180 min. Secondary outcomes included repeat measures of FEV
                1
                , serum potassium, heart rate, and adverse events
              
            
            
              Results
              
                Of 39 patients randomised, two withdrew due to adverse events (QT
                CF
                prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean (
                sd
                ) change from baseline FEV
                1
                180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean (
                sd
                ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95\% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV
                1
                from 30 to 240 min, but lesser FEV
                1
                at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events.
              
            
            
              Conclusion
              
                The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose
                −1
                and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta
                2
                -agonist and cardiovascular effects and more adverse events.},
	language = {en},
	urldate = {2022-03-04},
	journal = {European Respiratory Journal},
	author = {Kearns, Nethmi and Bruce, Pepa and Williams, Mathew and Doppen, Marjan and Black, Melissa and Weatherall, Mark and Beasley, Richard},
	month = feb,
	year = {2022},
	pages = {2102309},
}



@article{hatter_respiratory_2021,
	title = {Respiratory syncytial virus: paying the immunity debt with interest},
	issn = {23524642},
	shorttitle = {Respiratory syncytial virus},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333},
	doi = {10.1016/S2352-4642(21)00333-3},
	language = {en},
	urldate = {2021-10-28},
	journal = {The Lancet Child \& Adolescent Health},
	author = {Hatter, Lee and Eathorne, Allie and Hills, Thomas and Bruce, Pepa and Beasley, Richard},
	month = oct,
	year = {2021},
	pages = {S2352464221003333},
}



@article{foster_patient_2020,
	title = {Patient experiences of as-needed budesonide-formoterol by {Turbuhaler}® for treatment of mild asthma; a qualitative study},
	volume = {175},
	issn = {09546111},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948},
	doi = {10.1016/j.rmed.2020.106154},
	language = {en},
	urldate = {2021-05-12},
	journal = {Respiratory Medicine},
	author = {Foster, J.M. and Beasley, R. and Braithwaite, I. and Harrison, T. and Holliday, M. and Pavord, I. and Reddel, H.K.},
	month = dec,
	year = {2020},
	pages = {106154},
}



@article{beasley_anti-interleukin-5_2020,
	title = {Anti-interleukin-5 therapy in patients with severe asthma: from clinical trials to clinical practice},
	volume = {8},
	issn = {22132600},
	shorttitle = {Anti-interleukin-5 therapy in patients with severe asthma},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515},
	doi = {10.1016/S2213-2600(20)30051-5},
	language = {en},
	number = {5},
	urldate = {2021-05-07},
	journal = {The Lancet Respiratory Medicine},
	author = {Beasley, Richard and Harper, James and Masoli, Matthew},
	month = may,
	year = {2020},
	pages = {425--427},
}



@article{beasley_twentyfive_2020,
	title = {Twenty‐five years of {Respirology}: {Advances} in asthma},
	volume = {25},
	issn = {1323-7799, 1440-1843},
	shorttitle = {Twenty‐five years of \textit{{Respirology}}},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735},
	doi = {10.1111/resp.13735},
	language = {en},
	number = {1},
	urldate = {2021-05-07},
	journal = {Respirology},
	author = {Beasley, Richard and Gibson, Peter},
	month = jan,
	year = {2020},
	pages = {11--13},
}



@article{beasley_ics-formoterol_2020,
	title = {{ICS}-formoterol reliever therapy stepwise treatment algorithm for adult asthma},
	volume = {55},
	issn = {0903-1936, 1399-3003},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019},
	doi = {10.1183/13993003.01407-2019},
	language = {en},
	number = {1},
	urldate = {2021-05-07},
	journal = {European Respiratory Journal},
	author = {Beasley, Richard and Braithwaite, Irene and Semprini, Alex and Kearns, Ciléin and Weatherall, Mark and Harrison, Tim W. and Papi, Alberto and Pavord, Ian D.},
	month = jan,
	year = {2020},
	pages = {1901407},
}



@article{baggott_patient_2020,
	title = {Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma: findings from the {PRACTICAL} study, a randomised clinical trial},
	volume = {55},
	issn = {0903-1936, 1399-3003},
	shorttitle = {Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019},
	doi = {10.1183/13993003.02073-2019},
	abstract = {Symptom-driven low-dose inhaled corticosteroid–formoterol is safe and effective in mild asthma and has been recommended as one of the preferred treatment regimens at steps 1 and 2 in the 2019 update of the Global Initiative for Asthma. However, there are no data on patient preferences for this regimen.
            A subgroup of participants in the PRACTICAL study (ACTRN12616000377437), a randomised controlled trial comparing symptom-driven budesonide–formoterol with maintenance budesonide plus as-needed terbutaline completed a survey on treatment preferences, satisfaction, beliefs and experience at their final study visit.
            306 (75\%) out of 407 eligible participants completed the survey. Regimen preference was strongly associated with randomised treatment, as were preferences for and beliefs about preventer inhaler use. Combination preventer and reliever as-needed therapy was preferred by 135 (90\%, 95\% CI 85.2–94.8\%) out of 150 who were randomised to as-needed budesonide–formoterol, and by 63 (40\%, 95\% CI 32.7–48.1\%) out of 156 who were randomised to maintenance budesonide. By contrast, twice-daily preventer inhaler with a reliever inhaler as required was preferred by 15 (10\%) out of 150 of those randomised to as-needed budesonide–formoterol and 93 (60\%) out of 156 of those randomised to maintenance budesonide. Satisfaction with all study inhalers was high. Of patients randomised to as-needed budesonide–formoterol 92\% (n=138) were confident using it as a reliever at the end of the study.
            Although most participants preferred the regimen to which they had been randomised, this association was much stronger for those randomised to budesonide–formoterol as needed, indicating that most patients preferred as-needed corticosteroid–formoterol therapy if they had experienced it.},
	language = {en},
	number = {4},
	urldate = {2021-05-07},
	journal = {European Respiratory Journal},
	author = {Baggott, Christina and Reddel, Helen K. and Hardy, Jo and Sparks, Jenny and Holliday, Mark and Corin, Andrew and Montgomery, Barney and Reid, Jim and Sheahan, Davitt and Hancox, Robert J. and Weatherall, Mark and Beasley, Richard and Fingleton, James},
	month = apr,
	year = {2020},
	pages = {1902073},
}



@article{baggott_what_2020,
	title = {What matters most to patients when choosing treatment for mild–moderate asthma? {Results} from a discrete choice experiment},
	volume = {75},
	issn = {0040-6376, 1468-3296},
	shorttitle = {What matters most to patients when choosing treatment for mild–moderate asthma?},
	url = {https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343},
	doi = {10.1136/thoraxjnl-2019-214343},
	abstract = {Background
              An as-needed combination preventer and reliever regimen was recently introduced as an alternative to conventional daily preventer treatment for mild asthma. In a subgroup analysis of the PRACTICAL study, a pragmatic randomised controlled trial of budesonide–formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild asthma, we recently reported that about two-thirds preferred as-needed combination preventer and reliever therapy. The aim of this study was to determine the relative importance of attributes associated with these two asthma therapies in this subgroup of participants who indicated their preferred treatment in the PRACTICAL study.
            
            
              Methods
              At their final study visit, a subgroup of participants indicated their preferred treatment and completed a discrete choice experiment using the Potentially All Pairwise RanKings of all possible Alternatives method and 1000minds software. Treatment attributes and their levels were selected from measurable study outcomes, and included: treatment regimen, shortness of breath, steroid dose and likelihood of asthma flare-up.
            
            
              Results
              The final analysis dataset included 288 participants, 64\% of whom preferred as-needed combination preventer and reliever. Of the attributes, no shortness of breath and lowest risk of asthma flare-up were ranked highest and second highest, respectively. However, the relative importance of the other two attributes varied by preferred therapy: treatment regimen was ranked higher by participants who preferred as-needed treatment than by participants who preferred maintenance treatment.
            
            
              Conclusions
              Knowledge of patient preferences for treatment attributes together with regimen characteristics can be used in shared decision-making regarding choice of treatment for patients with mild–moderate asthma.
            
            
              Trial registration number
              ACTRN12616000377437.},
	language = {en},
	number = {10},
	urldate = {2021-05-05},
	journal = {Thorax},
	author = {Baggott, Christina and Hansen, Paul and Hancox, Robert J and Hardy, Jo Katherine and Sparks, Jenny and Holliday, Mark and Weatherall, Mark and Beasley, Richard and Reddel, Helen K and Fingleton, James},
	month = oct,
	year = {2020},
	pages = {842--848},
}



@article{hardy_combination_2020,
	title = {Combination budesonide/formoterol inhaler as sole reliever therapy in {Māori} and {Pacific} people with mild and moderate asthma},
	volume = {133},
	issn = {1175-8716},
	abstract = {AIM: In the PRACTICAL study, as-needed budesonide/formoterol reduced the rate of severe exacerbations compared with maintenance budesonide plus as-needed terbutaline. In a pre-specified analysis we analysed the efficacy in Māori and Pacific peoples, populations with worse asthma outcomes.
METHOD: The PRACTICAL study was a 52-week, open-label, parallel group, randomised controlled trial of 890 adults with mild to moderate asthma, who were randomised to budesonide/formoterol Turbuhaler 200/6mcg one actuation as required or budesonide Turbuhaler 200mcg one actuation twice daily and terbutaline Turbuhaler 250mcg two actuations as required. The primary outcome was rate of severe exacerbations. The analysis strategy was to test an ethnicity-treatment interaction term for each outcome variable.
RESULTS: Seventy-two participants (8\%) identified as Māori, 36 participants (4\%) as Pacific ethnicity. There was no evidence that ethnicity was an effect modifier for severe exacerbations (P interaction 0.70).
CONCLUSION: The reduction in severe exacerbation risk with budesonide-formoterol reliever compared with maintenance budesonide was similar in Māori and Pacific adults compared with New Zealand European/Other.},
	language = {eng},
	number = {1520},
	journal = {The New Zealand Medical Journal},
	author = {Hardy, Jo and Tewhaiti-Smith, Jordan and Baggott, Christina and Fingleton, James and Semprini, Alex and Holliday, Mark and Hancox, Robert J. and Weatherall, Mark and Harwood, Matire},
	month = aug,
	year = {2020},
	pmid = {32994594},
	keywords = {Administration, Inhalation, Adult, Anti-Asthmatic Agents, Asthma, Bronchodilator Agents, Budesonide, Budesonide, Formoterol Fumarate Drug Combination, Case-Control Studies, Disease Progression, Drug Therapy, Combination, Ethnic Groups, Female, Humans, Male, Middle Aged, Nebulizers and Vaporizers, New Zealand, Outcome Assessment, Health Care, Terbutaline, Treatment Outcome},
	pages = {61--72},
}



@article{bush_has_2021,
	title = {Has the time come to end use of the blue inhaler?},
	issn = {22132600},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855},
	doi = {10.1016/S2213-2600(21)00185-5},
	language = {en},
	urldate = {2021-05-02},
	journal = {The Lancet Respiratory Medicine},
	author = {Bush, Andrew and Dalziel, Stuart R and Byrnes, Catherine A and Hatter, Lee and Beasley, Richard},
	month = apr,
	year = {2021},
	pages = {S2213260021001855},
}



@article{papi_budesonideformoterol_2021,
	title = {Budesonide–formoterol reliever therapy in intermittent versus mild persistent asthma},
	volume = {57},
	issn = {0903-1936, 1399-3003},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020},
	doi = {10.1183/13993003.03064-2020},
	language = {en},
	number = {2},
	urldate = {2021-04-30},
	journal = {European Respiratory Journal},
	author = {Papi, Alberto and Braithwaite, Irene and Ebmeier, Stefan and Hancox, Robert J. and Harrison, Tim and Holliday, Mark and Houghton, Claire and Morandi, Luca and Oldfield, Karen and Pavord, Ian D. and Reddel, Helen K. and Williams, Mathew and Weatherall, Mark and Beasley, Richard},
	month = feb,
	year = {2021},
	pages = {2003064},
}



@article{karlsson_validation_2021,
	title = {Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or {COPD}},
	volume = {7},
	issn = {2312-0541},
	url = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020},
	doi = {10.1183/23120541.00828-2020},
	abstract = {Background
              The Respiratory Symptoms Questionnaire (RSQ) is a novel, four-item patient-reported diagnosis-agnostic tool designed to assess the frequency of respiratory symptoms and their impact on activity, without specifying a particular diagnosis. Our objective was to examine its validity in patients with asthma and/or chronic obstructive pulmonary disease (COPD).
            
            
              Methods
              
                Baseline data were randomly sampled from patients who completed the RSQ in the NOVELTY study (
                ClinicalTrials.gov
                :
                NCT02760329
                ). The total sample (n=1530) comprised three randomly selected samples (n=510 each) from each physician-assigned diagnostic group (asthma, asthma+COPD and COPD). The internal consistency and structural validity of the RSQ were evaluated using exploratory and confirmatory factor analyses; psychometric performance was observed using Classical Test Theory and Item Response Theory analyses.
              
            
            
              Results
              
                For the total sample, the mean±
                sd
                RSQ score was 5.6±4.3 (range 0–16). Irrespective of diagnosis, the internal consistency of items was uniformly adequate (Cronbach's α=0.76–0.80). All items had high factor loadings and structural characteristics of the measure were invariant across groups. Using the total sample, RSQ items informatively covered the θ score range of –2.0 to 2.8, with discrimination coefficients for individual items being high to very high (1.7–2.6). Strong convergent correlations were observed between the RSQ and the St George's Respiratory Questionnaire (0.77, p{\textless}0.001).
              
            
            
              Conclusions
              The RSQ is a valid, brief, patient-reported tool for assessing respiratory symptoms in patients across the whole spectrum of asthma and/or COPD, rather than using different questionnaires for each diagnosis. It can be used for monitoring respiratory symptoms in clinical practice, clinical trials and real-world studies.},
	language = {en},
	number = {1},
	urldate = {2021-04-30},
	journal = {ERJ Open Research},
	author = {Karlsson, Niklas and Atkinson, Mark J. and Müllerová, Hana and Alacqua, Marianna and Keen, Christina and Hughes, Rod and Janson, Christer and Make, Barry and Price, David and Reddel, Helen K.},
	month = jan,
	year = {2021},
	pages = {00828--2020},
}



@article{shaw_balancing_2021,
	title = {Balancing the needs of the many and the few: where next for adult asthma guidelines?},
	issn = {22132600},
	shorttitle = {Balancing the needs of the many and the few},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217},
	doi = {10.1016/S2213-2600(21)00021-7},
	language = {en},
	urldate = {2021-04-28},
	journal = {The Lancet Respiratory Medicine},
	author = {Shaw, Dominick E and Heaney, Liam G and Thomas, Mike and Beasley, Richard and Gibson, Peter G and Pavord, Ian D},
	month = feb,
	year = {2021},
	pages = {S2213260021000217},
}



@article{reddel_heterogeneity_2021,
	title = {Heterogeneity within and between physician-diagnosed asthma and/or {COPD}: {NOVELTY} cohort},
	issn = {0903-1936, 1399-3003},
	shorttitle = {Heterogeneity within and between physician-diagnosed asthma and/or {COPD}},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020},
	doi = {10.1183/13993003.03927-2020},
	abstract = {Background
              Studies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding of disease mechanisms and treatment options. NOVELTY is a global, 3-year, prospective observational study of patients with asthma and/or COPD from real-world clinical practice. We investigated heterogeneity and overlap by diagnosis and severity in this cohort.
            
            
              Methods
              Patients with physician-assigned asthma, COPD or both (asthma+COPD) were enrolled, stratified by diagnosis and severity. Baseline characteristics were reported descriptively by physician-assigned diagnosis and/or severity. Factors associated with physician-assessed severity were evaluated using ordinal logistic regression analysis.
            
            
              Results
              
                Of 11 243 patients, 5940 (52.8\%) had physician-assigned asthma, 1396 (12.4\%) had asthma+COPD and 3907 (34.8\%) had COPD; almost half were from primary care. Symptoms, health-related quality of life and spirometry showed substantial heterogeneity and overlap between asthma, asthma+COPD and COPD, with 23\%, 62\% and 64\% of patients, respectively, having post-bronchodilator FEV
                1
                /FVC {\textless}lower limit of normal.
              
              Symptoms and exacerbations increased with greater physician-assessed severity, and were higher in asthma+COPD, but 24.3\% with mild asthma and 20.4\% with mild COPD had experienced ≥1 exacerbation in the past 12 months. Medication records suggested both under-treatment and over-treatment relative to severity. Blood eosinophil counts varied little across diagnosis/severity groups, but blood neutrophil counts increased with severity across all diagnoses.
            
            
              Conclusion
              This analysis demonstrates marked heterogeneity within, and overlap between, physician-assigned diagnosis and severity groups in patients with asthma and/or COPD. Current diagnostic and severity classifications in clinical practice poorly differentiate between clinical phenotypes that may have specific risks and treatment implications.},
	language = {en},
	urldate = {2021-04-28},
	journal = {European Respiratory Journal},
	author = {Reddel, Helen K and Vestbo, Jørgen and Agustí, Alvar and Anderson, Gary P and Bansal, Aruna T and Beasley, Richard and Bel, Elisabeth H and Janson, Christer and Make, Barry and Pavord, Ian D and Price, David and Rapsomaniki, Eleni and Karlsson, Niklas and Finch, Donna K and Nuevo, Javier and de Giorgio-Miller, Alex and Alacqua, Marianna and Hughes, Rod and Müllerová, Hana and Gerhardsson de Verdier, Maria},
	month = feb,
	year = {2021},
	pages = {2003927},
}



@article{chang_more_2021,
	title = {More options for managing severe asthma in adults},
	volume = {9},
	issn = {22132600},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982},
	doi = {10.1016/S2213-2600(20)30398-2},
	language = {en},
	number = {1},
	urldate = {2021-04-28},
	journal = {The Lancet Respiratory Medicine},
	author = {Chang, Anne B and Beasley, Richard},
	month = jan,
	year = {2021},
	pages = {3--5},
}



@article{braithwaite_inhaled_2021,
	title = {Inhaled {JAK} inhibitor {GDC}-0214 reduces exhaled nitric oxide in patients with mild asthma: {A} randomized, controlled, proof-of-activity trial},
	issn = {00916749},
	shorttitle = {Inhaled {JAK} inhibitor {GDC}-0214 reduces exhaled nitric oxide in patients with mild asthma},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X},
	doi = {10.1016/j.jaci.2021.02.042},
	language = {en},
	urldate = {2021-04-28},
	journal = {Journal of Allergy and Clinical Immunology},
	author = {Braithwaite, Irene E. and Cai, Fang and Tom, Jennifer A. and Galanter, Joshua M. and Owen, Ryan P. and Zhu, Rui and Williams, Mathew and McGregor, Anna G. and Eliahu, Avi and Durk, Matthew R. and Dengler, Hart S. and Zak, Mark and Kenny, Jane R. and Wilson, Maria E. and Beasley, Richard and Chen, Hubert},
	month = mar,
	year = {2021},
	pages = {S009167492100422X},
}



@article{beasley_vexed_2021,
	title = {The {Vexed} {Problem} of {Corticosteroid} {Toxicity} in {Asthma}: {Time} for {Standardized} {Assessment}},
	volume = {9},
	issn = {22132198},
	shorttitle = {The {Vexed} {Problem} of {Corticosteroid} {Toxicity} in {Asthma}},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193},
	doi = {10.1016/j.jaip.2020.09.001},
	language = {en},
	number = {1},
	urldate = {2021-04-28},
	journal = {The Journal of Allergy and Clinical Immunology: In Practice},
	author = {Beasley, Richard and Weatherall, Mark},
	month = jan,
	year = {2021},
	pages = {373--374},
}



@article{beasley_asthma_2021-1,
	title = {Asthma and {COVID}-19: {Preconceptions} about {Predisposition}},
	volume = {203},
	issn = {1073-449X, 1535-4970},
	shorttitle = {Asthma and {COVID}-19},
	url = {https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED},
	doi = {10.1164/rccm.202102-0266ED},
	language = {en},
	number = {7},
	urldate = {2021-04-28},
	journal = {American Journal of Respiratory and Critical Care Medicine},
	author = {Beasley, Richard and Hills, Thomas and Kearns, Nethmi},
	month = apr,
	year = {2021},
	pages = {799--801},
}



@article{hatter_ics-formoterol_2021,
	title = {{ICS}-formoterol reliever versus {ICS} and short-acting β2 -agonist reliever in asthma: a systematic review and meta-analysis},
	volume = {7},
	issn = {2312-0541},
	shorttitle = {{ICS}-formoterol reliever \textit{versus} {ICS} and short-acting β $_{\textrm{2}}$ -agonist reliever in asthma},
	url = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020},
	doi = {10.1183/23120541.00701-2020},
	abstract = {Background
              
                The Global Initiative for Asthma recommends as-needed inhaled corticosteroid (ICS)-formoterol as an alternative to maintenance ICS plus short-acting β
                2
                -agonist (SABA) reliever at step 2 of its stepwise treatment algorithm. Our aim was to assess the efficacy and safety of these two treatment regimens, with a focus on prevention of severe exacerbation.
              
            
            
              Methods
              We performed a systematic review and meta-analysis of all randomised controlled trials (RCTs) comparing as-needed ICS-formoterol with maintenance ICS plus SABA. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrials.gov were searched from database inception to 12 December 2019. The primary outcome was time to first severe exacerbation. RCTs were excluded if they used as-needed budesonide-formoterol as part of a maintenance and reliever regimen, or did not report on severe exacerbations. The review is registered with PROSPERO (identifier number CRD42020154680).
            
            
              Results
              Four RCTs (n=8065 participants) were included in the analysis. As-needed ICS-formoterol was associated with a prolonged time to first severe exacerbation (hazard ratio 0.85, 95\% CI 0.73–1.00; p=0.048) and reduced daily ICS dose (mean difference −177.3 μg, 95\% CI −182.2–−172.4 μg). Asthma symptom control was worse in the as-needed group (Asthma Control Questionnaire-5 mean difference 0.12, 95\% CI 0.09–0.14), although this did not meet the minimal clinically important difference of 0.50 units. There was no significant difference in serious adverse events (OR 1.07, 95\% CI 0.84–1.36).
            
            
              Conclusion
              As-needed ICS-formoterol offers a therapeutic alternative to maintenance low-dose ICS plus SABA in asthma and may be the preferred option when prevention of severe exacerbation is the primary aim of treatment.},
	language = {en},
	number = {1},
	urldate = {2021-04-28},
	journal = {ERJ Open Research},
	author = {Hatter, Lee and Bruce, Pepa and Braithwaite, Irene and Holliday, Mark and {James Fingleton} and Weatherall, Mark and Beasley, Richard},
	month = jan,
	year = {2021},
	pages = {00701--2020},
}



@article{obyrne_management_2021,
	title = {The management of mild asthma},
	volume = {57},
	issn = {0903-1936, 1399-3003},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020},
	doi = {10.1183/13993003.03051-2020},
	abstract = {Inhaled corticosteroids (ICSs) have been recommended as a maintenance treatment, either alone or together with long-acting inhaled β
              2
              -agonists, for all asthma patients. Short-acting β
              2
              -agonists (SABAs) are rapid-onset bronchodilators, which provide symptom relief, but have no anti-inflammatory properties, yet are the most widely used as-needed reliever treatment for asthma and often the only treatment prescribed. Asthma patients can find adhering to daily preventative medication with ICS difficult and will often revert to using as-needed SABA as their only treatment, increasing their risk of exacerbations. The purpose of this review is to evaluate the efficacy of reliever medications that contain ICS compared with SABA as reliever, or with maintenance ICS and SABA as reliever, in mild asthma patients.
            
            Nine studies were identified that have evaluated the use of ICS as a component of an as-needed reliever in patients with mild asthma. Four of the most recent studies compared the combination of ICS/formoterol to SABA as reliever.
            ICS-containing reliever medication was superior to SABA as reliever alone, and was equivalent to maintenance ICS and SABA as reliever, particularly in reducing risks of severe asthma exacerbations, in studies which compared these reliever options.
            SABAs should not be used as a reliever without ICS. The concern about patients with mild asthma not being adherent to maintenance ICS supports a recommendation that ICS/formoterol should be considered as a treatment option instead of maintenance ICS, to avoid the risk of patients reverting to SABA alone.},
	language = {en},
	number = {4},
	urldate = {2021-04-11},
	journal = {European Respiratory Journal},
	author = {O'Byrne, Paul M. and Reddel, Helen K. and Beasley, Richard},
	month = apr,
	year = {2021},
	pages = {2003051},
}



@article{baggott_patient_2020-1,
	title = {Patient preferences for asthma management: a qualitative study},
	volume = {10},
	issn = {2044-6055, 2044-6055},
	shorttitle = {Patient preferences for asthma management},
	url = {http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491},
	doi = {10.1136/bmjopen-2020-037491},
	abstract = {Objective
              Preference for asthma management and the use of medications is motivated by the interplay between lived experiences of asthma and patients’ attitudes towards medications. Many previous studies have focused on individual aspects of asthma management, such as the use of preventer and reliever inhalers. The aim of this qualitative study was to explore the preferences of patients with mild-moderate asthma for asthma management as a whole and factors that influenced these preferences.
            
            
              Design
              A qualitative study employing qualitative descriptive analysis situated within a constructionist epistemology to analyse transcribed audio recordings from focus groups.
            
            
              Setting
              Three locations within the greater Wellington area in New Zealand.
            
            
              Participants
              
                Twenty-seven adults with self-reported doctor’s diagnosis of asthma, taking short-acting beta-agonists alone or inhaled corticosteroids with or without long-acting beta
                2
                -agonist, who had used any inhaled asthma medication within the last month.
              
            
            
              Results
              Four key areas described preferences for asthma management. Preferences for self-management: participants wanted to be in control of their asthma and developed personal strategies to achieve this. Preferences for the specific medications or treatment regimen: participants preferred regimens that were convenient and reliably relieved symptoms. Preferences for inhaler devices: devices that had dose counters and were easy to use and portable were important. Preferences for asthma services: participants wanted easier access to their inhalers and to be empowered by their healthcare providers. Participant preferences within each of these four areas were influenced by the impact asthma had on their life, their health beliefs, emotional consequences of asthma and perceived barriers to asthma management.
            
            
              Conclusions
              This study illustrates the interaction of the lived experience of asthma, factors specific to the individual, and factors relating to asthma treatments in shaping patient preferences for asthma management. This aids our understanding of preferences for asthma management from the patient perspective.
            
            
              Trial registration number
              Australian New Zealand Clinical Trials Registry (ACTRN12619000601134).},
	language = {en},
	number = {8},
	urldate = {2020-09-03},
	journal = {BMJ Open},
	author = {Baggott, Christina and Chan, Amy and Hurford, Sally and Fingleton, James and Beasley, Richard and Harwood, Matire and Reddel, Helen K and Levack, William Mark Magnus},
	month = aug,
	year = {2020},
	note = {Number: 8},
	pages = {e037491},
}



@article{baggott_self-titration_2020,
	title = {Self-titration of inhaled corticosteroid and β2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the {PRACTICAL} randomised controlled trial},
	volume = {56},
	issn = {0903-1936, 1399-3003},
	shorttitle = {Self-titration of inhaled corticosteroid and β $_{\textrm{2}}$ -agonist in response to symptoms in mild asthma},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020},
	doi = {10.1183/13993003.00170-2020},
	abstract = {Introduction
              
                In mild asthma, as-needed budesonide–formoterol is superior or noninferior to maintenance budesonide plus as-needed short-acting β
                2
                -agonist in reducing severe exacerbations. In this pre-specified analysis, we investigated patterns of inhaled corticosteroid (ICS) and β
                2
                -agonist use in PRACTICAL, a randomised controlled trial.
              
            
            
              Methods
              
                Participants were randomised 1:1 to as-needed budesonide–formoterol (200/6 μg Turbuhaler, one actuation) or maintenance budesonide (200 μg Turbuhaler, one actuation twice a day) with as-needed terbutaline (250 μg, two actuations) for 52 weeks. 110 participants had electronic monitors attached to their study inhalers which captured the time and date of every actuation. Key outcome measures were patterns of ICS and β
                2
                -agonist use. One actuation of budesonide–formoterol was considered to be an equivalent bronchodilator dose as two actuations of terbutaline.
              
            
            
              Results
              
                Participants randomised to as-needed budesonide–formoterol had more days with no ICS use compared with maintenance budesonide (median total days of no use 156
                versus
                22 days, respectively), lower median daily budesonide dose (164
                versus
                328 μg, respectively) and a greater median number of days of ≥4 budesonide actuations (4
                versus
                1 days, respectively). Participants randomised to as-needed budesonide–formoterol took higher equivalent doses of β
                2
                -agonist both overall (median number of actuations 0.8
                versus
                0.3 per day, respectively) and in response to worsening asthma (total number of “overuse days” of {\textgreater}8 or {\textgreater}16 actuations of budesonide–formoterol or terbutaline 33
                versus
                10 days, respectively).
              
            
            
              Conclusions
              
                The timing of ICS dose when self-titrated to β
                2
                -agonist use is more important than total ICS dose in reducing severe exacerbation risk in mild asthma, when associated with greater overall use of as-needed β
                2
                -agonist.},
	language = {en},
	number = {4},
	urldate = {2020-10-13},
	journal = {European Respiratory Journal},
	author = {Baggott, Christina and Hardy, Jo and Sparks, Jenny and Holliday, Mark and Hall, Daniela and Vohlidkova, Alexandra and Hancox, Robert J. and Weatherall, Mark and Fingleton, James and Beasley, Richard},
	month = oct,
	year = {2020},
	note = {Number: 4},
	pages = {2000170},
}



@article{kearns_inhaled_2020,
	title = {Inhaled {Corticosteroids} in {Acute} {Asthma}: {A} {Systemic} {Review} and {Meta}-{Analysis}},
	volume = {8},
	issn = {22132198},
	shorttitle = {Inhaled {Corticosteroids} in {Acute} {Asthma}},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767},
	doi = {10.1016/j.jaip.2019.08.051},
	language = {en},
	number = {2},
	urldate = {2020-09-28},
	journal = {The Journal of Allergy and Clinical Immunology: In Practice},
	author = {Kearns, Nethmi and Maijers, Ingrid and Harper, James and Beasley, Richard and Weatherall, Mark},
	month = feb,
	year = {2020},
	note = {Number: 2},
	pages = {605--617.e6},
}



@article{beasley_reducing_2020,
	title = {Reducing the burden of asthma: time to set research and clinical priorities},
	issn = {22132600},
	shorttitle = {Reducing the burden of asthma},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008},
	doi = {10.1016/S2213-2600(20)30400-8},
	language = {en},
	urldate = {2020-09-11},
	journal = {The Lancet Respiratory Medicine},
	author = {Beasley, Richard and Hancox, Robert J},
	month = sep,
	year = {2020},
	pages = {S2213260020304008},
}



@article{semprini_change_2019,
	title = {Change in biomarkers of type-2 inflammation following severe exacerbations of asthma},
	volume = {74},
	issn = {0040-6376, 1468-3296},
	url = {http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657},
	doi = {10.1136/thoraxjnl-2018-211657},
	abstract = {We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33×10
              9
              /L, p{\textless}0.001) while serum IgE levels were at their highest (339 vs 249 U/L, p{\textless}0.001). Fractional exhaled Nitric Oxide levels were lowest 2 weeks after treatment (23 vs 33 ppb, p=0.06) and serum periostin levels were lowest 1 week after treatment (45·9 vs 50·9 ng/mL, p{\textless}0.001). A delay of 4–8 weeks following a severe exacerbation is required if these biomarkers are used to guide the ongoing management of patients with asthma.
            
            
              Trial registration number
              Post-results; The Australia New Zealand Trial Registry, {\textgreater}ACTRN12614000443695.},
	language = {en},
	number = {1},
	urldate = {2020-08-23},
	journal = {Thorax},
	author = {Semprini, Ruth and Shortt, Nick and Ebmeier, Stefan and Semprini, Alex and Varughese, Rachel and Holweg, Cecile T J and Matthews, John G and Fingleton, James and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},
	month = jan,
	year = {2019},
	note = {Number: 1},
	pages = {95--98},
}



@article{morales_combined_2019,
	title = {Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: {ISAAC} phase {III}},
	volume = {74},
	issn = {0040-6376, 1468-3296},
	shorttitle = {Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children},
	url = {http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668},
	doi = {10.1136/thoraxjnl-2018-212668},
	abstract = {Background
              Asthma is not the key focus of prevention strategies. A Healthy Lifestyle Index (HLI) was developed to examine the combined effect of modifiable lifestyle factors on asthma, rhinoconjunctivitis and eczema using data from the International Study of Asthma and Allergies in Childhood (ISAAC) phase III.
            
            
              Methods
              Information on symptoms of asthma, rhinoconjunctivitis, eczema and several lifestyle factors was obtained from children aged 6–7 years through written questionnaires. The HLI combined five lifestyle factors: no parental smoking, child’s adherence to Mediterranean diet, child’s healthy body mass index, high physical activity and non-sedentary behaviour. The association between the HLI and risk of asthma, rhinoconjunctivitis and eczema was evaluated using multilevel mixed-effects logistic regression models.
            
            
              Findings
              Data of 70 795 children from 37 centres in 19 countries were analysed. Each additional healthy lifestyle factor was associated with a reduced risk of current wheeze (OR 0.87, 95\% CI 0.84 to 0.89), asthma ever (OR 0.89, 95\% CI 0.87 to 0.92), current symptoms of rhinoconjunctivitis (OR 0.95, 95\% CI 0.92 to 0.97) and current symptoms of eczema (OR 0.92, 95\% CI 0.92 to 0.98). Theoretically, if associations were causal, a combination of four or five healthy lifestyle factors would result into a reduction up to 16\% of asthma cases (ranging from 2.7\% to 26.3 \% according to region of the world).
            
            
              Conclusions
              These findings should be interpreted with caution given the limitations to infer causality from cross-sectional observational data. Efficacy of interventions to improve multiple modifiable lifestyle factors to reduce the burden asthma and allergy in childhood should be assessed.},
	language = {en},
	number = {6},
	urldate = {2020-08-23},
	journal = {Thorax},
	author = {Morales, Eva and Strachan, David and Asher, Innes and Ellwood, Philippa and Pearce, Neil and Garcia-Marcos, Luis},
	month = jun,
	year = {2019},
	note = {Number: 6},
	pages = {531--538},
}



@article{hardy_budesonide-formoterol_2019,
	title = {Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma ({PRACTICAL}): a 52-week, open-label, multicentre, superiority, randomised controlled trial},
	volume = {394},
	issn = {01406736},
	shorttitle = {Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma ({PRACTICAL})},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488},
	doi = {10.1016/S0140-6736(19)31948-8},
	language = {en},
	number = {10202},
	urldate = {2020-08-23},
	journal = {The Lancet},
	author = {Hardy, Jo and Baggott, Christina and Fingleton, James and Reddel, Helen K and Hancox, Robert J and Harwood, Matire and Corin, Andrew and Sparks, Jenny and Hall, Daniela and Sabbagh, Doñah and Mane, Saras and Vohlidkova, Alexandra and Martindale, John and Williams, Mathew and Shirtcliffe, Philippa and Holliday, Mark and Weatherall, Mark and Beasley, Richard and Corin, Andrew and Dronfield, Liz and Helm, Colin and Paterson, Tracy and Poudel, Bhuwan and Dyer, Malcolm and Jasinski, Christine and Sheahan, Davitt and Sheahan, Pamela and Gailer, Nick and Van Zuilen, Jan and Basa, Andy and Devereaux, Christine and Egan, Karin and Haughey, Sneha and Marks, Rodney and Venter, Dirk and Zhang, Hank and Trevithick, Karen and Williams, Mike and Williams, Philippa and Baggott, Christina and Beasley, Richard and Braithwaite, Irene and Eathorne, Alexandra and Ebmeier, Stefan and Fingleton, James and Hall, Daniela and Hardy, Jo and Harwood, Matire and Holliday, Mark and Houghton, Claire and Mane, Saras and Martindale, John and Oldfield, Karen and Pilcher, Janine and Sabbagh, Doñah and Shirtcliffe, Philippa and Snively, Suzanne and Sparks, Jenny and Vohlidkova, Alexandra and Williams, Mathew and Collins, Patrick and Hassan, Summer and Lam, Annika and Lionnet, Claudette and Montgomery, Barney and Smaill, Liz and Moon, Stella and Quinn, Dean and Bayly-McCredie, Elena and Millar-Coote, Chris and Millar-Coote, Dean and Reid, Jim and Samuel, Anna and Burton, Nicola and Mullard, Tina and Tranquilino, Tyronne and Watson, Edward and Bell, Jill and Harris, Rachel and Richmond, John and Smith, Sue and Krivan, Brent and Robertson, Cheryl and Hancox, Robert J and Weatherall, Mark and Glensor, Sue and O'Connor, Dermot and Porrachia, Anne-Christine and Reddel, Helen K},
	month = sep,
	year = {2019},
	note = {Number: 10202},
	pages = {919--928},
}



@article{denton_severe_2019,
	title = {Severe {Asthma} {Global} {Evaluation} ({SAGE}): {An} {Electronic} {Platform} for {Severe} {Asthma}},
	volume = {7},
	issn = {22132198},
	shorttitle = {Severe {Asthma} {Global} {Evaluation} ({SAGE})},
	url = {https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X},
	doi = {10.1016/j.jaip.2019.02.042},
	language = {en},
	number = {5},
	urldate = {2020-08-23},
	journal = {The Journal of Allergy and Clinical Immunology: In Practice},
	author = {Denton, Eve and Hore-Lacy, Fiona and Radhakrishna, Naghmeh and Gilbert, Annie and Tay, TunnRen and Lee, Joy and Dabscheck, Eli and Harvey, Erin S. and Bulathsinhala, Lakmini and Fingleton, James and Price, David and Gibson, Peter G. and O'Hehir, Robyn and Hew, Mark},
	month = may,
	year = {2019},
	note = {Number: 5},
	pages = {1440--1449},
}



@article{boudewijn_nasal_2020,
	title = {Nasal gene expression changes with inhaled corticosteroid treatment in asthma},
	volume = {75},
	issn = {1398-9995},
	doi = {10.1111/all.13952},
	language = {eng},
	number = {1},
	journal = {Allergy},
	author = {Boudewijn, Ilse M. and Lan, Andy and Faiz, Alen and Cox, Claire A. and Brouwer, Sharon and Schokker, Siebrig and Vroegop, Sebastiaan J. and Nawijn, Martijn C. and Woodruff, Prescott G. and Christenson, Stephanie A. and Hagedoorn, Paul and Frijlink, Henderik W. and Choy, David F. and Brouwer, Uilke and Wisman, Marissa and Postma, Dirkje S. and Fingleton, James and Beasley, Richard and van den Berge, Maarten and Guryev, Victor},
	year = {2020},
	pmid = {31230369},
	note = {Number: 1},
	pages = {191--194},
}



@article{beasley_dose-response_2019,
	title = {Dose-response relationship of {ICS}/fast-onset {LABA} as reliever therapy in asthma},
	volume = {19},
	issn = {1471-2466},
	url = {https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4},
	doi = {10.1186/s12890-019-1014-4},
	language = {en},
	number = {1},
	urldate = {2020-08-23},
	journal = {BMC Pulmonary Medicine},
	author = {Beasley, Richard and Harper, James and Bird, Grace and Dunphy, Harriette and Semprini, Alex and Pavord, Ian D. and Papi, Alberto and Weatherall, Mark},
	month = dec,
	year = {2019},
	note = {Number: 1},
	pages = {264},
}



@article{beasley_controlled_2019,
	title = {Controlled {Trial} of {Budesonide}–{Formoterol} as {Needed} for {Mild} {Asthma}},
	volume = {380},
	issn = {0028-4793, 1533-4406},
	url = {http://www.nejm.org/doi/10.1056/NEJMoa1901963},
	doi = {10.1056/NEJMoa1901963},
	language = {en},
	number = {21},
	urldate = {2020-08-23},
	journal = {New England Journal of Medicine},
	author = {Beasley, Richard and Holliday, Mark and Reddel, Helen K. and Braithwaite, Irene and Ebmeier, Stefan and Hancox, Robert J. and Harrison, Tim and Houghton, Claire and Oldfield, Karen and Papi, Alberto and Pavord, Ian D. and Williams, Mathew and Weatherall, Mark},
	month = may,
	year = {2019},
	note = {Number: 21},
	pages = {2020--2030},
}



@article{beasley_trial_1993,
	title = {Trial of an asthma action plan in the {Maori} community of the {Wairarapa}},
	volume = {106},
	issn = {0028-8446},
	abstract = {AIMS: An asthma action plan has been tested in a study conducted by Wairarapa Maori community health workers and the Wellington asthma research group. There were several distinctive features of the project, including the programme of marae-based asthma clinics, and the partnership between the researchers and the Maori community groups. This paper describes the process by which the study was conducted since this experience may be relevant to future Maori health research projects.
METHODS: The programme was launched with a series of hui at marae in the Wairarapa, and marae-based clinics were set up. These were followed up by further support from the Maori community health workers who helped people to keep diaries to monitor their asthma, and generally maintained contact. The severity of asthma in the participants was compared for a two-month period before the action plan was introduced, and for a four-month period after the plan was introduced.
RESULTS: There was a high participation rate, with 91\% (63/69) of participants finishing the programme, 75\% of whom adequately completed their daily asthma diaries. Asthma control improved significantly in the participants. They commented positively on the programme, and particularly on the marae-based clinics.
CONCLUSIONS: The study was successful in terms of participation in the marae-based clinics, acceptance and use of the plan, and improvement in asthma control of the participants. The findings indicate what can be achieved when researchers and Maori community groups work in partnership.},
	language = {eng},
	number = {961},
	journal = {The New Zealand Medical Journal},
	author = {Beasley, R. and D'Souza, W. and Te Karu, H. and Fox, C. and Harper, M. and Robson, B. and Howden-Chapman, P. and Crane, J. and Burgess, C. and Woodman, K.},
	month = aug,
	year = {1993},
	pmid = {8341475},
	note = {Number: 961},
	keywords = {Asthma, Community Health Workers, European Continental Ancestry Group, Humans, New Zealand, Oceanic Ancestry Group, Patient Acceptance of Health Care, Patient Education as Topic, Program Evaluation},
	pages = {336--338},
}



@article{dsouza_asthma_2000,
	title = {Asthma morbidity 6 yrs after an effective asthma self-management programme in a {Maori} community},
	volume = {15},
	issn = {0903-1936, 1399-3003},
	url = {http://erj.ersjournals.com/content/15/3/464},
	doi = {10.1034/j.1399-3003.2000.15.07.x},
	language = {en},
	number = {3},
	urldate = {2020-07-13},
	journal = {European Respiratory Journal},
	author = {D'souza, W.j and Slater, T and Fox, C and Fox, B and Te Karu, H and Gemmell, T and Ratima, M.m and Pearce, N.e and Beasley, R.b},
	month = mar,
	year = {2000},
	note = {Number: 3},
	pages = {464--469},
}



@article{holt_efficacy_2005,
	title = {Efficacy of bupropion in the indigenous {Maori} population in {New} {Zealand}},
	volume = {60},
	issn = {0040-6376},
	url = {http://thorax.bmj.com/cgi/doi/10.1136/thx.2004.030239},
	doi = {10.1136/thx.2004.030239},
	language = {en},
	number = {2},
	urldate = {2020-07-13},
	journal = {Thorax},
	author = {Holt, S},
	month = feb,
	year = {2005},
	note = {Number: 2},
	pages = {120--123},
}



@article{bruce_antiinflammatory_2020,
	title = {Anti‐inflammatory reliever therapy in asthma: {The} evidence mounts but more is needed},
	volume = {25},
	issn = {1323-7799, 1440-1843},
	shorttitle = {Anti‐inflammatory reliever therapy in asthma},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13889},
	doi = {10.1111/resp.13889},
	language = {en},
	number = {8},
	urldate = {2020-07-15},
	journal = {Respirology},
	author = {Bruce, Pepa and Hatter, Lee and Beasley, Richard},
	month = aug,
	year = {2020},
	note = {Number: 8},
	pages = {776--778},
}



@incollection{beasley_pragmatic_2019,
	title = {Pragmatic {Randomized} {Controlled} {Trial} of {Budesonide}/{Formoterol} {Reliever} {Therapy} in {Adults} with {Mild} {Asthma}},
	isbn = {1073-449X},
	booktitle = {D101. {CLINICAL} {AND} {TRANSLATIONAL} {STUDIES} {IN} {ASTHMA} {AND} {COPD}},
	publisher = {American Thoracic Society},
	author = {Beasley, R W and Holliday, M and Reddel, H K and Braithwaite, I and Ebmeier, S and Hancox, R and Harrison, T and Houghton, C and Oldfield, K and Papi, A},
	year = {2019},
	pages = {A7477--A7477},
}



@article{baggott_triaging_2019,
	title = {Triaging treatable traits in asthma},
	volume = {24},
	issn = {1323-7799},
	number = {1},
	journal = {Respirology},
	author = {Baggott, Christina and Beasley, Richard},
	year = {2019},
	note = {Number: 1
Publisher: Wiley Online Library},
	pages = {5--6},
}



@article{beasley_asthma_2019,
	title = {Asthma paradoxes: time for a new approach across the spectrum of asthma severity},
	volume = {53},
	doi = {10.1183/13993003.00218-2019},
	journal = {European Respiratory Journal},
	author = {Beasley, Richard and Bird, Grace and Harper, James and Weatherall, Mark},
	year = {2019},
	pages = {1900218},
}



@article{beasley_inhaled_2019,
	title = {Inhaled {Corticosteroid} {Therapy} in {Adult} {Asthma}: {Time} for a {New} {Therapeutic} {Dose} {Terminology}},
	doi = {10.1164/rccm.201810-1868CI},
	journal = {American Journal of Respiratory and Critical Care Medicine},
	author = {Beasley, Richard and Harper, James and Bird, Grace and Maijers, Ingrid and Weatherall, Mark and D Pavord, Ian},
	year = {2019},
}



@article{hills_history_2020,
	title = {The history and future of short‐acting beta 2 ‐agonist therapy in asthma},
	volume = {25},
	issn = {1323-7799},
	url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13727},
	doi = {10.1111/resp.13727},
	number = {3},
	journal = {Respirology},
	author = {Hills, Thomas and Beasley, Richard},
	month = mar,
	year = {2020},
	note = {Number: 3},
	pages = {246--248},
}



@article{maijers_oral_2020,
	title = {Oral steroid-sparing effect of high-dose inhaled corticosteroids in asthma},
	volume = {55},
	issn = {0903-1936},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01147-2019},
	doi = {10.1183/13993003.01147-2019},
	number = {1},
	journal = {European Respiratory Journal},
	author = {Maijers, Ingrid and Kearns, Nethmi and Harper, James and Weatherall, Mark and Beasley, Richard},
	month = jan,
	year = {2020},
	note = {Number: 1},
	keywords = {Asthma},
	pages = {1901147},
}



@article{beasley_optimal_2020,
	title = {Optimal {Asthma} {Control}: {Time} for a {New} {Target}},
	issn = {1073-449X},
	url = {https://www.atsjournals.org/doi/10.1164/rccm.201910-1934CI},
	doi = {10.1164/rccm.201910-1934CI},
	journal = {American Journal of Respiratory and Critical Care Medicine},
	author = {Beasley, Richard and Braithwaite, Irene and Semprini, Alex and Kearns, Ciléin and Weatherall, Mark and Pavord, Ian D},
	month = jan,
	year = {2020},
	keywords = {Asthma},
	pages = {rccm.201910--1934CI},
}



@article{beasley_vitamin_2017,
	title = {Vitamin {D} and asthma: a case to answer},
	volume = {5},
	issn = {2213-2600},
	number = {11},
	journal = {The Lancet Respiratory Medicine},
	author = {Beasley, Richard and Weatherall, Mark},
	year = {2017},
	note = {Number: 11
Publisher: Elsevier},
	pages = {839--840},
}



@article{pilcher_validation_2016,
	title = {Validation of a metered dose inhaler electronic monitoring device: {Implications} for asthma clinical trial use},
	volume = {3},
	doi = {10.1136/bmjresp-2016-000128},
	journal = {BMJ Open Respiratory Research},
	author = {Pilcher, Janine and Holliday, Mark and Ebmeier, Stefan and McKinstry, Steve and Messaoudi, Fatiha and Weatherall, Mark and Beasley, Richard},
	year = {2016},
	pages = {e000128},
}



@article{pilcher_use_2013,
	title = {{USE} {OF} {RELIABLE} {ELECTRONIC} {MONITORS} {IS} {THE} {OPTIMAL} {METHOD} {TO} {ASSESS} {PATTERNS} {OF} {INHALED} {ASTHMA} {MEDICATION} {USE}},
	volume = {18},
	journal = {Respirology},
	author = {Pilcher, J and Patel, M and Pritchard, A and Black, P and Weatherall, Mark and Beasley, Richard},
	year = {2013},
	pages = {45},
}



@article{ebmeier_trends_2017,
	title = {Trends in international asthma mortality: {Analysis} of data from the {WHO} {Mortality} {Database} from 46 countries (1993-2012)},
	volume = {390},
	doi = {10.1016/S0140-6736(17)31448-4},
	journal = {The Lancet},
	author = {Ebmeier, Stefan and Thayabaran, Darmiga and Braithwaite, Irene and Bénamara, Clément and Weatherall, Mark and Beasley, Richard},
	year = {2017},
}



@article{patel_use_2013,
	title = {Use of {Metered}-{Dose} {Inhaler} {Electronic} {Monitoring} in a {Real}-{World} {Asthma} {Randomized} {Controlled} {Trial}},
	volume = {1},
	doi = {10.1016/j.jaip.2012.08.004},
	journal = {The journal of allergy and clinical immunology in practice},
	author = {Patel, Mitesh and Pilcher, Janine and Travers, Justin and Perrin, Kyle and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard},
	year = {2013},
	pages = {83--91},
}



@article{semprini_type_2018,
	title = {Type 2 {Biomarkers} and {Prediction} of {Future} {Exacerbations} and {Lung} {Function} {Decline} in {Adult} {Asthma}},
	volume = {6},
	doi = {10.1016/j.jaip.2018.03.004},
	journal = {The Journal of Allergy and Clinical Immunology: In Practice},
	author = {Semprini, Ruth and Williams, Mathew and Semprini, Alex and McDouall, Alice and Fingleton, James and Holweg, Cécile and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},
	year = {2018},
}



@article{pilcher_three-month_2015,
	title = {Three-month validation of a turbuhaler electronic monitoring device: {Implications} for asthma clinical trial use},
	volume = {2},
	doi = {10.1136/bmjresp-2015-000097},
	journal = {BMJ Open Respiratory Research},
	author = {Pilcher, Janine and Shirtcliffe, Philippa and Patel, Mitesh and McKinstry, Steve and Cripps, Terrianne and Weatherall, Mark and Beasley, Richard},
	year = {2015},
	pages = {e000097},
}



@article{beasley_further_2018,
	title = {The further paradoxes of asthma management: {Time} for a new approach across the spectrum of asthma severity},
	volume = {52},
	doi = {10.1183/13993003.00694-2018},
	journal = {European Respiratory Journal},
	author = {Beasley, Richard and Bird, Grace and Harper, James and Weatherall, Mark},
	year = {2018},
	pages = {1800694},
}



@article{braithwaite_clinical_2018,
	title = {The {Clinical} {Relevance} of {Periostin} in {Asthma}},
	volume = {4},
	doi = {10.23866/BRNRev:2017-0028},
	journal = {Barcelona Respiratory Network},
	author = {Braithwaite, Irene and Semprini, Ruth and Beasley, Richard},
	year = {2018},
}



@article{mitchell_association_2012,
	title = {The association between tobacco and the risk of asthma, rhinoconjunctivitis and eczema in children and adolescents: analyses from {Phase} {Three} of the {ISAAC} programme},
	volume = {67},
	doi = {10.1136/thoraxjnl-2011-200901},
	journal = {Thorax},
	author = {Mitchell, Edwin and Beasley, Richard and Keil, Ulrich and Montefort, Stephen and Odhiambo, Joseph},
	year = {2012},
	pages = {941--949},
}



@article{weatherall_association_2014,
	title = {The association between paracetamol use and asthma: {Causation} or coincidence?},
	volume = {45},
	doi = {10.1111/cea.12410},
	journal = {Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
	author = {Weatherall, Mark and Ioannides, Sally and Braithwaite, Irene and Beasley, Richard},
	year = {2014},
}



@article{patel_six-month_2012,
	title = {Six-month in vitro validation of a metered-dose inhaler electronic monitoring device: {Implications} for asthma clinical trial use},
	volume = {130},
	doi = {10.1016/j.jaci.2012.06.037},
	journal = {The Journal of allergy and clinical immunology},
	author = {Patel, Mitesh and Pilcher, Janine and Chan, Amy and Perrin, Kyle and Black, Peter and Beasley, Richard},
	year = {2012},
}



@article{pilcher_single_2013,
	title = {{SINGLE} {BUDESONIDE}/{FORMOTEROL} {INHALER} {AS} {MAINTENANCE} {AND} {RELIEVER} {THERAPY} {IS} {BENEFICIAL} {IN} {MAORI} {ASTHMA}},
	volume = {18},
	journal = {Respirology},
	author = {Pilcher, J and Patel, M and Smith, A and Davies, Cheryl and Harwood, Matire and Weatherall, Mark and Beasley, Richard},
	year = {2013},
	pages = {44},
}



@article{patel_short-acting_2013,
	title = {Short-{Acting} β-{Agonist} {Use} {As} a {Marker} of {Current} {Asthma} {Control}},
	volume = {1},
	doi = {10.1016/j.jaip.2013.04.008},
	journal = {The Journal of Allergy and Clinical Immunology: In Practice},
	author = {Patel, Mitesh and Pilcher, Janine and Munro, Claire and Hosking, Alexander and Pritchard, Alison and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard},
	year = {2013},
	pages = {370--377},
}



@article{varughese_serum_2018,
	title = {Serum periostin levels following small bone fractures, long bone fractures and joint replacements: {An} observational study},
	volume = {14},
	doi = {10.1186/s13223-018-0254-9},
	journal = {Allergy, Asthma \& Clinical Immunology},
	author = {Varughese, Rachel and Semprini, Ruth and Munro, Claire and Fingleton, James and Holweg, Cecile and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},
	year = {2018},
}



@article{strachan_siblings_2015,
	title = {Siblings, asthma, rhinoconjunctivitis and eczema: a worldwide perspective from the {International} {Study} of {Asthma} and {Allergies} in {Childhood}},
	volume = {45},
	issn = {0954-7894},
	number = {1},
	journal = {Clinical \& Experimental Allergy},
	author = {Strachan, D P and Aït‐Khaled, N and Foliaki, S and Mallol, J and Odhiambo, J and Pearce, N and Williams, H C and Group, ISAAC Phase Three Study},
	year = {2015},
	note = {Number: 1
Publisher: Wiley Online Library},
	pages = {126--136},
}



@article{tan_serum_2018,
	title = {Serum periostin levels in adults of {Chinese} descent: an observational study},
	volume = {14},
	doi = {10.1186/s13223-018-0312-3},
	journal = {Allergy, Asthma \& Clinical Immunology},
	author = {Tan, Evan and Varughese, Rachel and Semprini, Ruth and Montgomery, Barney and Holweg, Cecile and Olsson, Julie and Caswell-Smith, Rachel and Fingleton, James and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},
	year = {2018},
}



@article{beasley_risk_2015,
	title = {Risk factors for asthma: {Is} prevention possible?},
	volume = {386},
	doi = {10.1016/S0140-6736(15)00156-7},
	journal = {Lancet (London, England)},
	author = {Beasley, Richard and Semprini, Alex and Mitchell, Edwin},
	year = {2015},
	pages = {1075--1085},
}



@article{beasley_restriction_2012,
	title = {Restriction of {LABA} use to combination {ICS}/{LABA} inhaler therapy in asthma},
	volume = {68},
	doi = {10.1136/thoraxjnl-2012-202483},
	journal = {Thorax},
	author = {Beasley, Richard and Fingleton, James and Weatherall, Mark},
	year = {2012},
}



@article{caswell-smith_reference_2016,
	title = {Reference ranges for serum periostin in a population without asthma or copd},
	volume = {46},
	doi = {10.1111/cea.12763},
	journal = {Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
	author = {Caswell-Smith, Rachel and Hosking, Alexander and Cripps, Terrianne and Holweg, Cécile and Matthews, J and Holliday, Mark and Maillot, Corentin and Fingleton, James and Weatherall, Mark and Braithwaite, Irene and Beasley, Richard},
	year = {2016},
}



@article{power_rct_2017,
	title = {{RCT} of the effect of berryfruit polyphenolic cultivar extract in mild steroid-naive asthma: a cross-over, placebo-controlled study},
	volume = {7},
	issn = {2044-6055},
	number = {3},
	journal = {BMJ open},
	author = {Power, Sharon and Williams, Mathew and Semprini, Alex and Munro, Claire and Caswell-Smith, Rachel and Pilcher, Janine and Holliday, Mark and Fingleton, James and Harper, Jacquie and Hurst, Roger},
	year = {2017},
	note = {Number: 3
Publisher: British Medical Journal Publishing Group},
	pages = {e013850},
}



@article{riley_randomized_2015,
	title = {Randomized controlled trial of asthma risk with paracetamol use in infancy–a feasibility study},
	volume = {45},
	issn = {0954-7894},
	number = {2},
	journal = {Clinical \& Experimental Allergy},
	author = {Riley, J and Braithwaite, I and Shirtcliffe, P and Caswell‐Smith, R and Hunt, A and Bowden, V and Power, S and Stanley, T and Crane, J and Ingham, T},
	year = {2015},
	note = {Number: 2
Publisher: Wiley Online Library},
	pages = {448--456},
}



@article{riley_randomized_2014,
	title = {Randomized {Controlled} {Trial} {Of} {Asthma} {Risk} {With} {Paracetamol} {Use} {In} {Infancy} - {A} {Feasibility} {Study}.},
	volume = {45},
	doi = {10.1111/cea.12433},
	journal = {Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
	author = {Riley, Judith and Braithwaite, Irene and Shirtcliffe, Philippa and Caswell-Smith, Rachel and Hunt, Anna and Bowden, Vanessa and Power, Sharon and Stanley, Thorsten and Crane, Julian and Ingham, Tristram and Weatherall, Mark and Mitchell, Edwin and Beasley, Richard},
	year = {2014},
}



@article{braithwaite_randomised_2016,
	title = {Randomised, double-blind, placebo-controlled, cross-over single dose study of the bronchodilator duration of action of combination fluticasone furoate/vilanterol inhaler in adult asthma},
	volume = {119},
	doi = {10.1016/j.rmed.2016.09.006},
	journal = {Respiratory Medicine},
	author = {Braithwaite, Irene and Williams, Mathew and Power, Sharon and Pilcher, Janine and Weatherall, Mark and Baines, Amanda and Moynihan, Jackie and Kempsford, Rodger and Beasley, Richard},
	year = {2016},
	pages = {115--121},
}



@article{ioannides_randomised_2014,
	title = {Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults},
	volume = {4},
	doi = {10.1136/bmjopen-2013-004324},
	journal = {BMJ open},
	author = {Ioannides, Sally and Williams, Mathew and Jefferies, Sarah and Perrin, Kyle and Weatherall, Mark and Siebers, Robert and Crane, Julian and Patel, Mitesh and Travers, Justin and Shirtcliffe, Philippa and Beasley, Richard},
	year = {2014},
	pages = {e004324},
}



@article{perrin_randomised_2011,
	title = {Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma},
	volume = {66},
	doi = {10.1136/thx.2010.155259},
	journal = {Thorax},
	author = {Perrin, Kyle and Wijesinghe, Meme and Healy, Bridget and Wadsworth, Kirsten and Bowditch, Richard and Bibby, Susan and Baker, Tanya and Weatherall, Mark and Beasley, Richard},
	year = {2011},
	pages = {937--941},
}



@article{patel_predictors_2014,
	title = {Predictors of {Severe} {Exacerbations}, {Poor} {Asthma} {Control}, and β-{Agonist} {Overuse} in {Asthma} for {Patients} with {Asthma}},
	volume = {2},
	doi = {10.1016/j.jaip.2014.06.001},
	journal = {The Journal of Allergy and Clinical Immunology: In Practice},
	author = {Patel, Mitesh and Pilcher, Janine and Reddel, Helen and Qi, Victoria and Mackey, Bill and Tranquilino, Tyronne and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard},
	year = {2014},
}



@article{riley_pilot_2016,
	title = {Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy},
	volume = {129},
	journal = {The New Zealand medical journal},
	author = {Riley, Judith and Hunt, Anna and McDouall, Alice and Waqanivavalagi, Steve and Braithwaite, Irene and Weatherall, Mark and Stanley, Thorsten and Beasley, Richard and Mitchell, Edwin and R Dalziel, Stuart},
	year = {2016},
	pages = {30--42},
}



@article{beasley_new_2017,
	title = {New {Zealand} asthma guidelines updated},
	volume = {130},
	issn = {1175-8716},
	number = {1466},
	journal = {The New Zealand Medical Journal (Online)},
	author = {Beasley, Richard and Hancox, Robert J},
	year = {2017},
	note = {Number: 1466
Publisher: New Zealand Medical Association (NZMA)},
	pages = {7--9},
}
\">\n            <i class=\"fa fa-download fa-fw\"></i> Download BibTeX\n          </a>\n        </li>\n        <li>\n          <a href=\"//bibbase.org/rss?bib=https://api.zotero.org/users/6607533/collections/EUK4Z2Y3/items?key=hGXLq241MCQA3ow7rlTIV2gY&amp;format=bibtex&amp;limit=100\">\n            <i class=\"fa fa-rss fa-fw\"></i> RSS Feed\n          </a>\n          </li>\n      </ul>\n      </li>\n\n      \n\n\n      \n    </ul>\n\n\n    <div class=\"alert alert-success bibbase_msg\" id=\"bibbase_msg_embed\"\n         style=\"display: none;\">\n\n      Excellent! 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In order to keep using Mendeley with BibBase past April\n        14th, you need to:\n        <ol>\n          <li>renew the authorization for BibBase on Mendeley, and</li>\n          <li>update the BibBase URL\n            in your page the same way you did when you initially set up\n            this page.\n          </li>\n        </ol>\n      </p>\n\n      <p>\n        <a href=\"http://bibbase.org/cgi-bin/mendeley2/get.py\">\n          <i class=\"fa fa-angle-double-right\"></i>\n          Fix it now</a>\n      </p>\n    </div>\n\n  </div>\n\n\n  <div id=\"bibbase_body\">\n    \n  \n  <div class=\"bibbase_group_whole\" id=\"group_2022\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2022')\"\n      onkeypress=\"toggleGroup('group_2022')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2022</span>\n      <span class=\"bibbase_group_count\">\n        \n        (4)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022', 'https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537', event);\">\n    Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Foster, J.; Beasley, R.; Braithwaite, I.; Harrison, T.; Holliday, M.; Pavord, I.;  and Reddel, H.\n</span>\n\n  \n\n</span>\n\n  <i>BMJ Open</i>, 12(1): e048537. January 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537\"\n     onclick=\"log_download('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022', 'https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1136/bmjopen-2020-048537\"\n     onclick=\"log_download('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022', 'http://doi.org/10.1136/bmjopen-2020-048537', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{foster_perspectives_2022,\n\ttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study},\n\tvolume = {12},\n\tissn = {2044-6055, 2044-6055},\n\tshorttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens},\n\turl = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537},\n\tdoi = {10.1136/bmjopen-2020-048537},\n\tabstract = {Objectives\n              As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens.\n            \n            \n              Setting\n              A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment.\n            \n            \n              Participants\n              Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings.\n            \n            \n              Results\n              Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it.\n            \n            \n              Conclusions\n              Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation.\n            \n            \n              Trial registration number\n              ACTRN12615000999538.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-03-27},\n\tjournal = {BMJ Open},\n\tauthor = {Foster, Juliet and Beasley, Richard and Braithwaite, Irene and Harrison, Tim and Holliday, Mark and Pavord, Ian and Reddel, Helen},\n\tmonth = jan,\n\tyear = {2022},\n\tpages = {e048537},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objectives As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens. Setting A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment. Participants Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings. Results Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it. Conclusions Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation. Trial registration number ACTRN12615000999538.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022', 'http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021', event);\">\n    Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype Oxford Asthma Attack Risk Scale (ORACLE).\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Couillard, S.; Do, W. I. H.; Beasley, R.; Hinks, T. S.;  and Pavord, I. D.\n</span>\n\n  \n\n</span>\n\n  <i>ERJ Open Research</i>, 8(1): 00570–2021. January 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021\"\n     onclick=\"log_download('couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022', 'http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype Oxford Asthma Attack Risk Scale (ORACLE) [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/23120541.00570-2021\"\n     onclick=\"log_download('couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022', 'http://doi.org/10.1183/23120541.00570-2021', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{couillard_predicting_2022,\n\ttitle = {Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype {Oxford} {Asthma} {Attack} {Risk} {Scale} ({ORACLE})},\n\tvolume = {8},\n\tissn = {2312-0541},\n\turl = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021},\n\tdoi = {10.1183/23120541.00570-2021},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-03-27},\n\tjournal = {ERJ Open Research},\n\tauthor = {Couillard, Simon and Do, William Il Hoon and Beasley, Richard and Hinks, Timothy S.C. and Pavord, Ian D.},\n\tmonth = jan,\n\tyear = {2022},\n\tpages = {00570--2021},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022', 'https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512', event);\">\n    Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma: A Systematic Review and Meta-analysis.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.; Harrison, T.; Peterson, S.; Gustafson, P.; Hamblin, A.; Bengtsson, T.;  and Fagerås, M.\n</span>\n\n  \n\n</span>\n\n  <i>JAMA Network Open</i>, 5(3): e220615. March 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512\"\n     onclick=\"log_download('beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022', 'https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma: A Systematic Review and Meta-analysis [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1001/jamanetworkopen.2022.0615\"\n     onclick=\"log_download('beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022', 'http://doi.org/10.1001/jamanetworkopen.2022.0615', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_evaluation_2022,\n\ttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}: {A} {Systematic} {Review} and {Meta}-analysis},\n\tvolume = {5},\n\tissn = {2574-3805},\n\tshorttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}},\n\turl = {https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512},\n\tdoi = {10.1001/jamanetworkopen.2022.0615},\n\tlanguage = {en},\n\tnumber = {3},\n\turldate = {2022-03-04},\n\tjournal = {JAMA Network Open},\n\tauthor = {Beasley, Richard and Harrison, Tim and Peterson, Stefan and Gustafson, Per and Hamblin, Angus and Bengtsson, Thomas and Fagerås, Malin},\n\tmonth = mar,\n\tyear = {2022},\n\tpages = {e220615},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021', event);\">\n    Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: A randomised cross-over trial.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Kearns, N.; Bruce, P.; Williams, M.; Doppen, M.; Black, M.; Weatherall, M.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>,2102309. February 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021\"\n     onclick=\"log_download('kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: A randomised cross-over trial [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.02309-2021\"\n     onclick=\"log_download('kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022', 'http://doi.org/10.1183/13993003.02309-2021', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{kearns_repeated_2022,\n\ttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: {A} randomised cross-over trial},\n\tissn = {0903-1936, 1399-3003},\n\tshorttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021},\n\tdoi = {10.1183/13993003.02309-2021},\n\tabstract = {Objective\n              \n                To determine the comparative bronchodilator, systemic beta\n                2\n                -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma.\n              \n            \n            \n              Methods\n              \n                This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg\n                via\n                MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg\n                via\n                nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation\n                via\n                Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV\n                1\n                after 180 min. Secondary outcomes included repeat measures of FEV\n                1\n                , serum potassium, heart rate, and adverse events\n              \n            \n            \n              Results\n              \n                Of 39 patients randomised, two withdrew due to adverse events (QT\n                CF\n                prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean (\n                sd\n                ) change from baseline FEV\n                1\n                180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean (\n                sd\n                ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95\\% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV\n                1\n                from 30 to 240 min, but lesser FEV\n                1\n                at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events.\n              \n            \n            \n              Conclusion\n              \n                The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose\n                −1\n                and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta\n                2\n                -agonist and cardiovascular effects and more adverse events.},\n\tlanguage = {en},\n\turldate = {2022-03-04},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Kearns, Nethmi and Bruce, Pepa and Williams, Mathew and Doppen, Marjan and Black, Melissa and Weatherall, Mark and Beasley, Richard},\n\tmonth = feb,\n\tyear = {2022},\n\tpages = {2102309},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objective To determine the comparative bronchodilator, systemic beta 2 -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma. Methods This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg via MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg via nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation via Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV 1 after 180 min. Secondary outcomes included repeat measures of FEV 1 , serum potassium, heart rate, and adverse events Results Of 39 patients randomised, two withdrew due to adverse events (QT CF prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean ( sd ) change from baseline FEV 1 180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean ( sd ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV 1 from 30 to 240 min, but lesser FEV 1 at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events. Conclusion The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose −1 and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta 2 -agonist and cardiovascular effects and more adverse events.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2021\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2021')\"\n      onkeypress=\"toggleGroup('group_2021')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2021</span>\n      <span class=\"bibbase_group_count\">\n        \n        (16)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"rogliani-beasley-cazzola-calzetta-smartforthetreatmentofasthmaanetworkmetaanalysisofrealworldevidence-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'rogliani-beasley-cazzola-calzetta-smartforthetreatmentofasthmaanetworkmetaanalysisofrealworldevidence-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X', event);\">\n    SMART for the treatment of asthma: A network meta-analysis of real-world evidence.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Rogliani, P.; Beasley, R.; Cazzola, M.;  and Calzetta, L.\n</span>\n\n  \n\n</span>\n\n  <i>Respiratory Medicine</i>, 188: 106611. November 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X\"\n     onclick=\"log_download('rogliani-beasley-cazzola-calzetta-smartforthetreatmentofasthmaanetworkmetaanalysisofrealworldevidence-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"SMART for the treatment of asthma: A network meta-analysis of real-world evidence [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.rmed.2021.106611\"\n     onclick=\"log_download('rogliani-beasley-cazzola-calzetta-smartforthetreatmentofasthmaanetworkmetaanalysisofrealworldevidence-2021', 'http://doi.org/10.1016/j.rmed.2021.106611', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/rogliani-beasley-cazzola-calzetta-smartforthetreatmentofasthmaanetworkmetaanalysisofrealworldevidence-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('rogliani-beasley-cazzola-calzetta-smartforthetreatmentofasthmaanetworkmetaanalysisofrealworldevidence-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{rogliani_smart_2021,\n\ttitle = {{SMART} for the treatment of asthma: {A} network meta-analysis of real-world evidence},\n\tvolume = {188},\n\tissn = {09546111},\n\tshorttitle = {{SMART} for the treatment of asthma},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S095461112100319X},\n\tdoi = {10.1016/j.rmed.2021.106611},\n\tlanguage = {en},\n\turldate = {2022-03-27},\n\tjournal = {Respiratory Medicine},\n\tauthor = {Rogliani, Paola and Beasley, Richard and Cazzola, Mario and Calzetta, Luigino},\n\tmonth = nov,\n\tyear = {2021},\n\tpages = {106611},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021', 'https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974', event);\">\n    Enhanced airway sensory nerve reactivity in non-eosinophilic asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Ali, H.; Brooks, C.; Crane, J.; Beasley, R.; Holgate, S.; Gibson, P.; Pattemore, P.; Tzeng, Y.; Stanley, T.; Pearce, N.;  and Douwes, J.\n</span>\n\n  \n\n</span>\n\n  <i>BMJ Open Respiratory Research</i>, 8(1): e000974. November 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974\"\n     onclick=\"log_download('ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021', 'https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Enhanced airway sensory nerve reactivity in non-eosinophilic asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1136/bmjresp-2021-000974\"\n     onclick=\"log_download('ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021', 'http://doi.org/10.1136/bmjresp-2021-000974', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('ali-brooks-crane-beasley-holgate-gibson-pattemore-tzeng-etal-enhancedairwaysensorynervereactivityinnoneosinophilicasthma-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{ali_enhanced_2021,\n\ttitle = {Enhanced airway sensory nerve reactivity in non-eosinophilic asthma},\n\tvolume = {8},\n\tissn = {2052-4439},\n\turl = {https://bmjopenrespres.bmj.com/lookup/doi/10.1136/bmjresp-2021-000974},\n\tdoi = {10.1136/bmjresp-2021-000974},\n\tabstract = {Background\n              Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics.\n            \n            \n              Methods\n              \n                Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5\\%. Airway hyperreactivity was defined as a ≥15\\% drop in FEV\n                1\n                during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs.\n              \n            \n            \n              Results\n              \n                Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95\\% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p{\\textless}0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV\n                1\n                was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed.\n              \n            \n            \n              Conclusion\n              NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-03-27},\n\tjournal = {BMJ Open Respiratory Research},\n\tauthor = {Ali, Hajar and Brooks, Collin and Crane, Julian and Beasley, Richard and Holgate, Stephen and Gibson, Peter and Pattemore, Philip and Tzeng, Yu-Chieh and Stanley, Thorsten and Pearce, Neil and Douwes, Jeroen},\n\tmonth = nov,\n\tyear = {2021},\n\tpages = {e000974},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Background Neural mechanisms may play an important role in non-eosinophilic asthma (NEA). This study compared airway sensory nerve reactivity, using capsaicin challenge, in eosinophilic asthma (EA) and NEA and non-asthmatics. Methods Thirty-eight asthmatics and 19 non-asthmatics (aged 14–21 years) underwent combined hypertonic saline challenge/sputum induction, fractional exhaled nitric oxide, atopy and spirometry tests, followed by capsaicin challenge. EA and NEA were defined using a sputum eosinophil cut-point of 2.5%. Airway hyperreactivity was defined as a ≥15% drop in FEV 1 during saline challenge. Sensory nerve reactivity was defined as the lowest capsaicin concentration that evoked 5 (C5) coughs. Results Non-eosinophilic asthmatics (n=20) had heightened capsaicin sensitivity (lower C5) compared with non-asthmatics (n=19) (geometric mean C5: 58.3 µM, 95% CI 24.1 to 141.5 vs 193.6 µM, 82.2 to 456.0; p\\textless0.05). NEA tended to also have greater capsaicin sensitivity than EA, with the difference in capsaicin sensitivity between NEA and EA being of similar magnitude (58.3 µM, 24.1 to 141.5 vs 191.0 µM, 70.9 to 514.0) to that observed between NEA and non-asthmatics; however, this did not reach statistical significance (p=0.07). FEV 1 was significantly reduced from baseline following capsaicin inhalation in both asthmatics and non-asthmatics but no differences were found between subgroups. No associations with capsaicin sensitivity and atopy, sputum eosinophils, blood eosinophils, asthma control or treatment were observed. Conclusion NEA, but not EA, showed enhanced capsaicin sensitivity compared with non-asthmatics. Sensory nerve reactivity may therefore play an important role in the pathophysiology of NEA.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"baggott-beasley-asthmaintheantiinflammatoryrelievertherapyera-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'baggott-beasley-asthmaintheantiinflammatoryrelievertherapyera-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653', event);\">\n    Asthma in the anti-inflammatory reliever therapy era.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Baggott, C.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet Respiratory Medicine</i>, 9(2): 118–119. February 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653\"\n     onclick=\"log_download('baggott-beasley-asthmaintheantiinflammatoryrelievertherapyera-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Asthma in the anti-inflammatory reliever therapy era [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S2213-2600(20)30465-3\"\n     onclick=\"log_download('baggott-beasley-asthmaintheantiinflammatoryrelievertherapyera-2021', 'http://doi.org/10.1016/S2213-2600(20)30465-3', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/baggott-beasley-asthmaintheantiinflammatoryrelievertherapyera-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('baggott-beasley-asthmaintheantiinflammatoryrelievertherapyera-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{baggott_asthma_2021,\n\ttitle = {Asthma in the anti-inflammatory reliever therapy era},\n\tvolume = {9},\n\tissn = {22132600},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020304653},\n\tdoi = {10.1016/S2213-2600(20)30465-3},\n\tlanguage = {en},\n\tnumber = {2},\n\turldate = {2022-03-27},\n\tjournal = {The Lancet Respiratory Medicine},\n\tauthor = {Baggott, Christina and Beasley, Richard},\n\tmonth = feb,\n\tyear = {2021},\n\tpages = {118--119},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021', 'https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED', event);\">\n    Asthma and COVID-19: Preconceptions about Predisposition.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.; Hills, T.;  and Kearns, N.\n</span>\n\n  \n\n</span>\n\n  <i>American Journal of Respiratory and Critical Care Medicine</i>, 203(7): 799–801. April 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED\"\n     onclick=\"log_download('beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021', 'https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Asthma and COVID-19: Preconceptions about Predisposition [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1164/rccm.202102-0266ED\"\n     onclick=\"log_download('beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021', 'http://doi.org/10.1164/rccm.202102-0266ED', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>2 downloads</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_asthma_2021,\n\ttitle = {Asthma and {COVID}-19: {Preconceptions} about {Predisposition}},\n\tvolume = {203},\n\tissn = {1073-449X, 1535-4970},\n\tshorttitle = {Asthma and {COVID}-19},\n\turl = {https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED},\n\tdoi = {10.1164/rccm.202102-0266ED},\n\tlanguage = {en},\n\tnumber = {7},\n\turldate = {2022-03-04},\n\tjournal = {American Journal of Respiratory and Critical Care Medicine},\n\tauthor = {Beasley, Richard and Hills, Thomas and Kearns, Nethmi},\n\tmonth = apr,\n\tyear = {2021},\n\tpages = {799--801},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"hatter-eathorne-hills-bruce-beasley-respiratorysyncytialviruspayingtheimmunitydebtwithinterest-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'hatter-eathorne-hills-bruce-beasley-respiratorysyncytialviruspayingtheimmunitydebtwithinterest-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333', event);\">\n    Respiratory syncytial virus: paying the immunity debt with interest.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Hatter, L.; Eathorne, A.; Hills, T.; Bruce, P.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet Child & Adolescent Health</i>,S2352464221003333. October 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333\"\n     onclick=\"log_download('hatter-eathorne-hills-bruce-beasley-respiratorysyncytialviruspayingtheimmunitydebtwithinterest-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Respiratory syncytial virus: paying the immunity debt with interest [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S2352-4642(21)00333-3\"\n     onclick=\"log_download('hatter-eathorne-hills-bruce-beasley-respiratorysyncytialviruspayingtheimmunitydebtwithinterest-2021', 'http://doi.org/10.1016/S2352-4642(21)00333-3', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/hatter-eathorne-hills-bruce-beasley-respiratorysyncytialviruspayingtheimmunitydebtwithinterest-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('hatter-eathorne-hills-bruce-beasley-respiratorysyncytialviruspayingtheimmunitydebtwithinterest-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{hatter_respiratory_2021,\n\ttitle = {Respiratory syncytial virus: paying the immunity debt with interest},\n\tissn = {23524642},\n\tshorttitle = {Respiratory syncytial virus},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2352464221003333},\n\tdoi = {10.1016/S2352-4642(21)00333-3},\n\tlanguage = {en},\n\turldate = {2021-10-28},\n\tjournal = {The Lancet Child \\&amp; Adolescent Health},\n\tauthor = {Hatter, Lee and Eathorne, Allie and Hills, Thomas and Bruce, Pepa and Beasley, Richard},\n\tmonth = oct,\n\tyear = {2021},\n\tpages = {S2352464221003333},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"bush-dalziel-byrnes-hatter-beasley-hasthetimecometoenduseoftheblueinhaler-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'bush-dalziel-byrnes-hatter-beasley-hasthetimecometoenduseoftheblueinhaler-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855', event);\">\n    Has the time come to end use of the blue inhaler?.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Bush, A.; Dalziel, S. R; Byrnes, C. A; Hatter, L.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet Respiratory Medicine</i>,S2213260021001855. April 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855\"\n     onclick=\"log_download('bush-dalziel-byrnes-hatter-beasley-hasthetimecometoenduseoftheblueinhaler-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Has the time come to end use of the blue inhaler? [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S2213-2600(21)00185-5\"\n     onclick=\"log_download('bush-dalziel-byrnes-hatter-beasley-hasthetimecometoenduseoftheblueinhaler-2021', 'http://doi.org/10.1016/S2213-2600(21)00185-5', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/bush-dalziel-byrnes-hatter-beasley-hasthetimecometoenduseoftheblueinhaler-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('bush-dalziel-byrnes-hatter-beasley-hasthetimecometoenduseoftheblueinhaler-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{bush_has_2021,\n\ttitle = {Has the time come to end use of the blue inhaler?},\n\tissn = {22132600},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260021001855},\n\tdoi = {10.1016/S2213-2600(21)00185-5},\n\tlanguage = {en},\n\turldate = {2021-05-02},\n\tjournal = {The Lancet Respiratory Medicine},\n\tauthor = {Bush, Andrew and Dalziel, Stuart R and Byrnes, Catherine A and Hatter, Lee and Beasley, Richard},\n\tmonth = apr,\n\tyear = {2021},\n\tpages = {S2213260021001855},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"papi-braithwaite-ebmeier-hancox-harrison-holliday-houghton-morandi-etal-budesonideformoterolrelievertherapyinintermittentversusmildpersistentasthma-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'papi-braithwaite-ebmeier-hancox-harrison-holliday-houghton-morandi-etal-budesonideformoterolrelievertherapyinintermittentversusmildpersistentasthma-2021', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020', event);\">\n    Budesonide–formoterol reliever therapy in intermittent versus mild persistent asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Papi, A.; Braithwaite, I.; Ebmeier, S.; Hancox, R. J.; Harrison, T.; Holliday, M.; Houghton, C.; Morandi, L.; Oldfield, K.; Pavord, I. D.; Reddel, H. K.; Williams, M.; Weatherall, M.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 57(2): 2003064. February 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020\"\n     onclick=\"log_download('papi-braithwaite-ebmeier-hancox-harrison-holliday-houghton-morandi-etal-budesonideformoterolrelievertherapyinintermittentversusmildpersistentasthma-2021', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Budesonide–formoterol reliever therapy in intermittent versus mild persistent asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.03064-2020\"\n     onclick=\"log_download('papi-braithwaite-ebmeier-hancox-harrison-holliday-houghton-morandi-etal-budesonideformoterolrelievertherapyinintermittentversusmildpersistentasthma-2021', 'http://doi.org/10.1183/13993003.03064-2020', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/papi-braithwaite-ebmeier-hancox-harrison-holliday-houghton-morandi-etal-budesonideformoterolrelievertherapyinintermittentversusmildpersistentasthma-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>2 downloads</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('papi-braithwaite-ebmeier-hancox-harrison-holliday-houghton-morandi-etal-budesonideformoterolrelievertherapyinintermittentversusmildpersistentasthma-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{papi_budesonideformoterol_2021,\n\ttitle = {Budesonide–formoterol reliever therapy in intermittent versus mild persistent asthma},\n\tvolume = {57},\n\tissn = {0903-1936, 1399-3003},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03064-2020},\n\tdoi = {10.1183/13993003.03064-2020},\n\tlanguage = {en},\n\tnumber = {2},\n\turldate = {2021-04-30},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Papi, Alberto and Braithwaite, Irene and Ebmeier, Stefan and Hancox, Robert J. and Harrison, Tim and Holliday, Mark and Houghton, Claire and Morandi, Luca and Oldfield, Karen and Pavord, Ian D. and Reddel, Helen K. and Williams, Mathew and Weatherall, Mark and Beasley, Richard},\n\tmonth = feb,\n\tyear = {2021},\n\tpages = {2003064},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"karlsson-atkinson-mllerov-alacqua-keen-hughes-janson-make-etal-validationofadiagnosisagnosticsymptomquestionnaireforasthmaandorcopd-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'karlsson-atkinson-mllerov-alacqua-keen-hughes-janson-make-etal-validationofadiagnosisagnosticsymptomquestionnaireforasthmaandorcopd-2021', 'http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020', event);\">\n    Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Karlsson, N.; Atkinson, M. J.; Müllerová, H.; Alacqua, M.; Keen, C.; Hughes, R.; Janson, C.; Make, B.; Price, D.;  and Reddel, H. K.\n</span>\n\n  \n\n</span>\n\n  <i>ERJ Open Research</i>, 7(1): 00828–2020. January 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020\"\n     onclick=\"log_download('karlsson-atkinson-mllerov-alacqua-keen-hughes-janson-make-etal-validationofadiagnosisagnosticsymptomquestionnaireforasthmaandorcopd-2021', 'http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or COPD [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/23120541.00828-2020\"\n     onclick=\"log_download('karlsson-atkinson-mllerov-alacqua-keen-hughes-janson-make-etal-validationofadiagnosisagnosticsymptomquestionnaireforasthmaandorcopd-2021', 'http://doi.org/10.1183/23120541.00828-2020', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/karlsson-atkinson-mllerov-alacqua-keen-hughes-janson-make-etal-validationofadiagnosisagnosticsymptomquestionnaireforasthmaandorcopd-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>2 downloads</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('karlsson-atkinson-mllerov-alacqua-keen-hughes-janson-make-etal-validationofadiagnosisagnosticsymptomquestionnaireforasthmaandorcopd-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{karlsson_validation_2021,\n\ttitle = {Validation of a diagnosis-agnostic symptom questionnaire for asthma and/or {COPD}},\n\tvolume = {7},\n\tissn = {2312-0541},\n\turl = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00828-2020},\n\tdoi = {10.1183/23120541.00828-2020},\n\tabstract = {Background\n              The Respiratory Symptoms Questionnaire (RSQ) is a novel, four-item patient-reported diagnosis-agnostic tool designed to assess the frequency of respiratory symptoms and their impact on activity, without specifying a particular diagnosis. Our objective was to examine its validity in patients with asthma and/or chronic obstructive pulmonary disease (COPD).\n            \n            \n              Methods\n              \n                Baseline data were randomly sampled from patients who completed the RSQ in the NOVELTY study (\n                ClinicalTrials.gov\n                :\n                NCT02760329\n                ). The total sample (n=1530) comprised three randomly selected samples (n=510 each) from each physician-assigned diagnostic group (asthma, asthma+COPD and COPD). The internal consistency and structural validity of the RSQ were evaluated using exploratory and confirmatory factor analyses; psychometric performance was observed using Classical Test Theory and Item Response Theory analyses.\n              \n            \n            \n              Results\n              \n                For the total sample, the mean±\n                sd\n                RSQ score was 5.6±4.3 (range 0–16). Irrespective of diagnosis, the internal consistency of items was uniformly adequate (Cronbach&#x27;s α=0.76–0.80). All items had high factor loadings and structural characteristics of the measure were invariant across groups. Using the total sample, RSQ items informatively covered the θ score range of –2.0 to 2.8, with discrimination coefficients for individual items being high to very high (1.7–2.6). Strong convergent correlations were observed between the RSQ and the St George&#x27;s Respiratory Questionnaire (0.77, p{\\textless}0.001).\n              \n            \n            \n              Conclusions\n              The RSQ is a valid, brief, patient-reported tool for assessing respiratory symptoms in patients across the whole spectrum of asthma and/or COPD, rather than using different questionnaires for each diagnosis. It can be used for monitoring respiratory symptoms in clinical practice, clinical trials and real-world studies.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-04-30},\n\tjournal = {ERJ Open Research},\n\tauthor = {Karlsson, Niklas and Atkinson, Mark J. and Müllerová, Hana and Alacqua, Marianna and Keen, Christina and Hughes, Rod and Janson, Christer and Make, Barry and Price, David and Reddel, Helen K.},\n\tmonth = jan,\n\tyear = {2021},\n\tpages = {00828--2020},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Background The Respiratory Symptoms Questionnaire (RSQ) is a novel, four-item patient-reported diagnosis-agnostic tool designed to assess the frequency of respiratory symptoms and their impact on activity, without specifying a particular diagnosis. Our objective was to examine its validity in patients with asthma and/or chronic obstructive pulmonary disease (COPD). Methods Baseline data were randomly sampled from patients who completed the RSQ in the NOVELTY study ( ClinicalTrials.gov : NCT02760329 ). The total sample (n=1530) comprised three randomly selected samples (n=510 each) from each physician-assigned diagnostic group (asthma, asthma+COPD and COPD). The internal consistency and structural validity of the RSQ were evaluated using exploratory and confirmatory factor analyses; psychometric performance was observed using Classical Test Theory and Item Response Theory analyses. Results For the total sample, the mean± sd RSQ score was 5.6±4.3 (range 0–16). Irrespective of diagnosis, the internal consistency of items was uniformly adequate (Cronbach's α=0.76–0.80). All items had high factor loadings and structural characteristics of the measure were invariant across groups. Using the total sample, RSQ items informatively covered the θ score range of –2.0 to 2.8, with discrimination coefficients for individual items being high to very high (1.7–2.6). Strong convergent correlations were observed between the RSQ and the St George's Respiratory Questionnaire (0.77, p\\textless0.001). Conclusions The RSQ is a valid, brief, patient-reported tool for assessing respiratory symptoms in patients across the whole spectrum of asthma and/or COPD, rather than using different questionnaires for each diagnosis. It can be used for monitoring respiratory symptoms in clinical practice, clinical trials and real-world studies.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"shaw-heaney-thomas-beasley-gibson-pavord-balancingtheneedsofthemanyandthefewwherenextforadultasthmaguidelines-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'shaw-heaney-thomas-beasley-gibson-pavord-balancingtheneedsofthemanyandthefewwherenextforadultasthmaguidelines-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217', event);\">\n    Balancing the needs of the many and the few: where next for adult asthma guidelines?.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Shaw, D. E; Heaney, L. G; Thomas, M.; Beasley, R.; Gibson, P. G;  and Pavord, I. D\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet Respiratory Medicine</i>,S2213260021000217. February 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217\"\n     onclick=\"log_download('shaw-heaney-thomas-beasley-gibson-pavord-balancingtheneedsofthemanyandthefewwherenextforadultasthmaguidelines-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Balancing the needs of the many and the few: where next for adult asthma guidelines? [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S2213-2600(21)00021-7\"\n     onclick=\"log_download('shaw-heaney-thomas-beasley-gibson-pavord-balancingtheneedsofthemanyandthefewwherenextforadultasthmaguidelines-2021', 'http://doi.org/10.1016/S2213-2600(21)00021-7', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/shaw-heaney-thomas-beasley-gibson-pavord-balancingtheneedsofthemanyandthefewwherenextforadultasthmaguidelines-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('shaw-heaney-thomas-beasley-gibson-pavord-balancingtheneedsofthemanyandthefewwherenextforadultasthmaguidelines-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{shaw_balancing_2021,\n\ttitle = {Balancing the needs of the many and the few: where next for adult asthma guidelines?},\n\tissn = {22132600},\n\tshorttitle = {Balancing the needs of the many and the few},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260021000217},\n\tdoi = {10.1016/S2213-2600(21)00021-7},\n\tlanguage = {en},\n\turldate = {2021-04-28},\n\tjournal = {The Lancet Respiratory Medicine},\n\tauthor = {Shaw, Dominick E and Heaney, Liam G and Thomas, Mike and Beasley, Richard and Gibson, Peter G and Pavord, Ian D},\n\tmonth = feb,\n\tyear = {2021},\n\tpages = {S2213260021000217},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"reddel-vestbo-agust-anderson-bansal-beasley-bel-janson-etal-heterogeneitywithinandbetweenphysiciandiagnosedasthmaandorcopdnoveltycohort-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'reddel-vestbo-agust-anderson-bansal-beasley-bel-janson-etal-heterogeneitywithinandbetweenphysiciandiagnosedasthmaandorcopdnoveltycohort-2021', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020', event);\">\n    Heterogeneity within and between physician-diagnosed asthma and/or COPD: NOVELTY cohort.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Reddel, H. K; Vestbo, J.; Agustí, A.; Anderson, G. P; Bansal, A. T; Beasley, R.; Bel, E. H; Janson, C.; Make, B.; Pavord, I. D; Price, D.; Rapsomaniki, E.; Karlsson, N.; Finch, D. K; Nuevo, J.; de Giorgio-Miller, A.; Alacqua, M.; Hughes, R.; Müllerová, H.;  and Gerhardsson de Verdier, M.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>,2003927. February 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020\"\n     onclick=\"log_download('reddel-vestbo-agust-anderson-bansal-beasley-bel-janson-etal-heterogeneitywithinandbetweenphysiciandiagnosedasthmaandorcopdnoveltycohort-2021', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Heterogeneity within and between physician-diagnosed asthma and/or COPD: NOVELTY cohort [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.03927-2020\"\n     onclick=\"log_download('reddel-vestbo-agust-anderson-bansal-beasley-bel-janson-etal-heterogeneitywithinandbetweenphysiciandiagnosedasthmaandorcopdnoveltycohort-2021', 'http://doi.org/10.1183/13993003.03927-2020', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/reddel-vestbo-agust-anderson-bansal-beasley-bel-janson-etal-heterogeneitywithinandbetweenphysiciandiagnosedasthmaandorcopdnoveltycohort-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('reddel-vestbo-agust-anderson-bansal-beasley-bel-janson-etal-heterogeneitywithinandbetweenphysiciandiagnosedasthmaandorcopdnoveltycohort-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{reddel_heterogeneity_2021,\n\ttitle = {Heterogeneity within and between physician-diagnosed asthma and/or {COPD}: {NOVELTY} cohort},\n\tissn = {0903-1936, 1399-3003},\n\tshorttitle = {Heterogeneity within and between physician-diagnosed asthma and/or {COPD}},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03927-2020},\n\tdoi = {10.1183/13993003.03927-2020},\n\tabstract = {Background\n              Studies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding of disease mechanisms and treatment options. NOVELTY is a global, 3-year, prospective observational study of patients with asthma and/or COPD from real-world clinical practice. We investigated heterogeneity and overlap by diagnosis and severity in this cohort.\n            \n            \n              Methods\n              Patients with physician-assigned asthma, COPD or both (asthma+COPD) were enrolled, stratified by diagnosis and severity. Baseline characteristics were reported descriptively by physician-assigned diagnosis and/or severity. Factors associated with physician-assessed severity were evaluated using ordinal logistic regression analysis.\n            \n            \n              Results\n              \n                Of 11 243 patients, 5940 (52.8\\%) had physician-assigned asthma, 1396 (12.4\\%) had asthma+COPD and 3907 (34.8\\%) had COPD; almost half were from primary care. Symptoms, health-related quality of life and spirometry showed substantial heterogeneity and overlap between asthma, asthma+COPD and COPD, with 23\\%, 62\\% and 64\\% of patients, respectively, having post-bronchodilator FEV\n                1\n                /FVC {\\textless}lower limit of normal.\n              \n              Symptoms and exacerbations increased with greater physician-assessed severity, and were higher in asthma+COPD, but 24.3\\% with mild asthma and 20.4\\% with mild COPD had experienced ≥1 exacerbation in the past 12 months. Medication records suggested both under-treatment and over-treatment relative to severity. Blood eosinophil counts varied little across diagnosis/severity groups, but blood neutrophil counts increased with severity across all diagnoses.\n            \n            \n              Conclusion\n              This analysis demonstrates marked heterogeneity within, and overlap between, physician-assigned diagnosis and severity groups in patients with asthma and/or COPD. Current diagnostic and severity classifications in clinical practice poorly differentiate between clinical phenotypes that may have specific risks and treatment implications.},\n\tlanguage = {en},\n\turldate = {2021-04-28},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Reddel, Helen K and Vestbo, Jørgen and Agustí, Alvar and Anderson, Gary P and Bansal, Aruna T and Beasley, Richard and Bel, Elisabeth H and Janson, Christer and Make, Barry and Pavord, Ian D and Price, David and Rapsomaniki, Eleni and Karlsson, Niklas and Finch, Donna K and Nuevo, Javier and de Giorgio-Miller, Alex and Alacqua, Marianna and Hughes, Rod and Müllerová, Hana and Gerhardsson de Verdier, Maria},\n\tmonth = feb,\n\tyear = {2021},\n\tpages = {2003927},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Background Studies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding of disease mechanisms and treatment options. NOVELTY is a global, 3-year, prospective observational study of patients with asthma and/or COPD from real-world clinical practice. We investigated heterogeneity and overlap by diagnosis and severity in this cohort. Methods Patients with physician-assigned asthma, COPD or both (asthma+COPD) were enrolled, stratified by diagnosis and severity. Baseline characteristics were reported descriptively by physician-assigned diagnosis and/or severity. Factors associated with physician-assessed severity were evaluated using ordinal logistic regression analysis. Results Of 11 243 patients, 5940 (52.8%) had physician-assigned asthma, 1396 (12.4%) had asthma+COPD and 3907 (34.8%) had COPD; almost half were from primary care. Symptoms, health-related quality of life and spirometry showed substantial heterogeneity and overlap between asthma, asthma+COPD and COPD, with 23%, 62% and 64% of patients, respectively, having post-bronchodilator FEV 1 /FVC \\textlesslower limit of normal. Symptoms and exacerbations increased with greater physician-assessed severity, and were higher in asthma+COPD, but 24.3% with mild asthma and 20.4% with mild COPD had experienced ≥1 exacerbation in the past 12 months. Medication records suggested both under-treatment and over-treatment relative to severity. Blood eosinophil counts varied little across diagnosis/severity groups, but blood neutrophil counts increased with severity across all diagnoses. Conclusion This analysis demonstrates marked heterogeneity within, and overlap between, physician-assigned diagnosis and severity groups in patients with asthma and/or COPD. Current diagnostic and severity classifications in clinical practice poorly differentiate between clinical phenotypes that may have specific risks and treatment implications.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"chang-beasley-moreoptionsformanagingsevereasthmainadults-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'chang-beasley-moreoptionsformanagingsevereasthmainadults-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982', event);\">\n    More options for managing severe asthma in adults.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Chang, A. B;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet Respiratory Medicine</i>, 9(1): 3–5. January 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982\"\n     onclick=\"log_download('chang-beasley-moreoptionsformanagingsevereasthmainadults-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"More options for managing severe asthma in adults [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S2213-2600(20)30398-2\"\n     onclick=\"log_download('chang-beasley-moreoptionsformanagingsevereasthmainadults-2021', 'http://doi.org/10.1016/S2213-2600(20)30398-2', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/chang-beasley-moreoptionsformanagingsevereasthmainadults-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('chang-beasley-moreoptionsformanagingsevereasthmainadults-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{chang_more_2021,\n\ttitle = {More options for managing severe asthma in adults},\n\tvolume = {9},\n\tissn = {22132600},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020303982},\n\tdoi = {10.1016/S2213-2600(20)30398-2},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-04-28},\n\tjournal = {The Lancet Respiratory Medicine},\n\tauthor = {Chang, Anne B and Beasley, Richard},\n\tmonth = jan,\n\tyear = {2021},\n\tpages = {3--5},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"braithwaite-cai-tom-galanter-owen-zhu-williams-mcgregor-etal-inhaledjakinhibitorgdc0214reducesexhalednitricoxideinpatientswithmildasthmaarandomizedcontrolledproofofactivitytrial-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'braithwaite-cai-tom-galanter-owen-zhu-williams-mcgregor-etal-inhaledjakinhibitorgdc0214reducesexhalednitricoxideinpatientswithmildasthmaarandomizedcontrolledproofofactivitytrial-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X', event);\">\n    Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Braithwaite, I. E.; Cai, F.; Tom, J. A.; Galanter, J. M.; Owen, R. P.; Zhu, R.; Williams, M.; McGregor, A. G.; Eliahu, A.; Durk, M. R.; Dengler, H. S.; Zak, M.; Kenny, J. R.; Wilson, M. E.; Beasley, R.;  and Chen, H.\n</span>\n\n  \n\n</span>\n\n  <i>Journal of Allergy and Clinical Immunology</i>,S009167492100422X. March 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X\"\n     onclick=\"log_download('braithwaite-cai-tom-galanter-owen-zhu-williams-mcgregor-etal-inhaledjakinhibitorgdc0214reducesexhalednitricoxideinpatientswithmildasthmaarandomizedcontrolledproofofactivitytrial-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Inhaled JAK inhibitor GDC-0214 reduces exhaled nitric oxide in patients with mild asthma: A randomized, controlled, proof-of-activity trial [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaci.2021.02.042\"\n     onclick=\"log_download('braithwaite-cai-tom-galanter-owen-zhu-williams-mcgregor-etal-inhaledjakinhibitorgdc0214reducesexhalednitricoxideinpatientswithmildasthmaarandomizedcontrolledproofofactivitytrial-2021', 'http://doi.org/10.1016/j.jaci.2021.02.042', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/braithwaite-cai-tom-galanter-owen-zhu-williams-mcgregor-etal-inhaledjakinhibitorgdc0214reducesexhalednitricoxideinpatientswithmildasthmaarandomizedcontrolledproofofactivitytrial-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('braithwaite-cai-tom-galanter-owen-zhu-williams-mcgregor-etal-inhaledjakinhibitorgdc0214reducesexhalednitricoxideinpatientswithmildasthmaarandomizedcontrolledproofofactivitytrial-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{braithwaite_inhaled_2021,\n\ttitle = {Inhaled {JAK} inhibitor {GDC}-0214 reduces exhaled nitric oxide in patients with mild asthma: {A} randomized, controlled, proof-of-activity trial},\n\tissn = {00916749},\n\tshorttitle = {Inhaled {JAK} inhibitor {GDC}-0214 reduces exhaled nitric oxide in patients with mild asthma},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S009167492100422X},\n\tdoi = {10.1016/j.jaci.2021.02.042},\n\tlanguage = {en},\n\turldate = {2021-04-28},\n\tjournal = {Journal of Allergy and Clinical Immunology},\n\tauthor = {Braithwaite, Irene E. and Cai, Fang and Tom, Jennifer A. and Galanter, Joshua M. and Owen, Ryan P. and Zhu, Rui and Williams, Mathew and McGregor, Anna G. and Eliahu, Avi and Durk, Matthew R. and Dengler, Hart S. and Zak, Mark and Kenny, Jane R. and Wilson, Maria E. and Beasley, Richard and Chen, Hubert},\n\tmonth = mar,\n\tyear = {2021},\n\tpages = {S009167492100422X},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-weatherall-thevexedproblemofcorticosteroidtoxicityinasthmatimeforstandardizedassessment-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-weatherall-thevexedproblemofcorticosteroidtoxicityinasthmatimeforstandardizedassessment-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193', event);\">\n    The Vexed Problem of Corticosteroid Toxicity in Asthma: Time for Standardized Assessment.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.;  and Weatherall, M.\n</span>\n\n  \n\n</span>\n\n  <i>The Journal of Allergy and Clinical Immunology: In Practice</i>, 9(1): 373–374. January 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193\"\n     onclick=\"log_download('beasley-weatherall-thevexedproblemofcorticosteroidtoxicityinasthmatimeforstandardizedassessment-2021', 'https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"The Vexed Problem of Corticosteroid Toxicity in Asthma: Time for Standardized Assessment [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaip.2020.09.001\"\n     onclick=\"log_download('beasley-weatherall-thevexedproblemofcorticosteroidtoxicityinasthmatimeforstandardizedassessment-2021', 'http://doi.org/10.1016/j.jaip.2020.09.001', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-weatherall-thevexedproblemofcorticosteroidtoxicityinasthmatimeforstandardizedassessment-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-weatherall-thevexedproblemofcorticosteroidtoxicityinasthmatimeforstandardizedassessment-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_vexed_2021,\n\ttitle = {The {Vexed} {Problem} of {Corticosteroid} {Toxicity} in {Asthma}: {Time} for {Standardized} {Assessment}},\n\tvolume = {9},\n\tissn = {22132198},\n\tshorttitle = {The {Vexed} {Problem} of {Corticosteroid} {Toxicity} in {Asthma}},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213219820309193},\n\tdoi = {10.1016/j.jaip.2020.09.001},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-04-28},\n\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\n\tauthor = {Beasley, Richard and Weatherall, Mark},\n\tmonth = jan,\n\tyear = {2021},\n\tpages = {373--374},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021', 'https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED', event);\">\n    Asthma and COVID-19: Preconceptions about Predisposition.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.; Hills, T.;  and Kearns, N.\n</span>\n\n  \n\n</span>\n\n  <i>American Journal of Respiratory and Critical Care Medicine</i>, 203(7): 799–801. April 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED\"\n     onclick=\"log_download('beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021', 'https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Asthma and COVID-19: Preconceptions about Predisposition [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1164/rccm.202102-0266ED\"\n     onclick=\"log_download('beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021', 'http://doi.org/10.1164/rccm.202102-0266ED', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>2 downloads</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-hills-kearns-asthmaandcovid19preconceptionsaboutpredisposition-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_asthma_2021-1,\n\ttitle = {Asthma and {COVID}-19: {Preconceptions} about {Predisposition}},\n\tvolume = {203},\n\tissn = {1073-449X, 1535-4970},\n\tshorttitle = {Asthma and {COVID}-19},\n\turl = {https://www.atsjournals.org/doi/10.1164/rccm.202102-0266ED},\n\tdoi = {10.1164/rccm.202102-0266ED},\n\tlanguage = {en},\n\tnumber = {7},\n\turldate = {2021-04-28},\n\tjournal = {American Journal of Respiratory and Critical Care Medicine},\n\tauthor = {Beasley, Richard and Hills, Thomas and Kearns, Nethmi},\n\tmonth = apr,\n\tyear = {2021},\n\tpages = {799--801},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"hatter-bruce-braithwaite-holliday-jamesfingleton-weatherall-beasley-icsformoterolrelieverversusicsandshortacting2agonistrelieverinasthmaasystematicreviewandmetaanalysis-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'hatter-bruce-braithwaite-holliday-jamesfingleton-weatherall-beasley-icsformoterolrelieverversusicsandshortacting2agonistrelieverinasthmaasystematicreviewandmetaanalysis-2021', 'http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020', event);\">\n    ICS-formoterol reliever versus ICS and short-acting β2 -agonist reliever in asthma: a systematic review and meta-analysis.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Hatter, L.; Bruce, P.; Braithwaite, I.; Holliday, M.; James Fingleton; Weatherall, M.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>ERJ Open Research</i>, 7(1): 00701–2020. January 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020\"\n     onclick=\"log_download('hatter-bruce-braithwaite-holliday-jamesfingleton-weatherall-beasley-icsformoterolrelieverversusicsandshortacting2agonistrelieverinasthmaasystematicreviewandmetaanalysis-2021', 'http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"ICS-formoterol reliever versus ICS and short-acting β2 -agonist reliever in asthma: a systematic review and meta-analysis [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/23120541.00701-2020\"\n     onclick=\"log_download('hatter-bruce-braithwaite-holliday-jamesfingleton-weatherall-beasley-icsformoterolrelieverversusicsandshortacting2agonistrelieverinasthmaasystematicreviewandmetaanalysis-2021', 'http://doi.org/10.1183/23120541.00701-2020', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/hatter-bruce-braithwaite-holliday-jamesfingleton-weatherall-beasley-icsformoterolrelieverversusicsandshortacting2agonistrelieverinasthmaasystematicreviewandmetaanalysis-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('hatter-bruce-braithwaite-holliday-jamesfingleton-weatherall-beasley-icsformoterolrelieverversusicsandshortacting2agonistrelieverinasthmaasystematicreviewandmetaanalysis-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{hatter_ics-formoterol_2021,\n\ttitle = {{ICS}-formoterol reliever versus {ICS} and short-acting β2 -agonist reliever in asthma: a systematic review and meta-analysis},\n\tvolume = {7},\n\tissn = {2312-0541},\n\tshorttitle = {{ICS}-formoterol reliever \\textit{versus} {ICS} and short-acting β $_{\\textrm{2}}$ -agonist reliever in asthma},\n\turl = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00701-2020},\n\tdoi = {10.1183/23120541.00701-2020},\n\tabstract = {Background\n              \n                The Global Initiative for Asthma recommends as-needed inhaled corticosteroid (ICS)-formoterol as an alternative to maintenance ICS plus short-acting β\n                2\n                -agonist (SABA) reliever at step 2 of its stepwise treatment algorithm. Our aim was to assess the efficacy and safety of these two treatment regimens, with a focus on prevention of severe exacerbation.\n              \n            \n            \n              Methods\n              We performed a systematic review and meta-analysis of all randomised controlled trials (RCTs) comparing as-needed ICS-formoterol with maintenance ICS plus SABA. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrials.gov were searched from database inception to 12 December 2019. The primary outcome was time to first severe exacerbation. RCTs were excluded if they used as-needed budesonide-formoterol as part of a maintenance and reliever regimen, or did not report on severe exacerbations. The review is registered with PROSPERO (identifier number CRD42020154680).\n            \n            \n              Results\n              Four RCTs (n=8065 participants) were included in the analysis. As-needed ICS-formoterol was associated with a prolonged time to first severe exacerbation (hazard ratio 0.85, 95\\% CI 0.73–1.00; p=0.048) and reduced daily ICS dose (mean difference −177.3 μg, 95\\% CI −182.2–−172.4 μg). Asthma symptom control was worse in the as-needed group (Asthma Control Questionnaire-5 mean difference 0.12, 95\\% CI 0.09–0.14), although this did not meet the minimal clinically important difference of 0.50 units. There was no significant difference in serious adverse events (OR 1.07, 95\\% CI 0.84–1.36).\n            \n            \n              Conclusion\n              As-needed ICS-formoterol offers a therapeutic alternative to maintenance low-dose ICS plus SABA in asthma and may be the preferred option when prevention of severe exacerbation is the primary aim of treatment.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-04-28},\n\tjournal = {ERJ Open Research},\n\tauthor = {Hatter, Lee and Bruce, Pepa and Braithwaite, Irene and Holliday, Mark and {James Fingleton} and Weatherall, Mark and Beasley, Richard},\n\tmonth = jan,\n\tyear = {2021},\n\tpages = {00701--2020},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Background The Global Initiative for Asthma recommends as-needed inhaled corticosteroid (ICS)-formoterol as an alternative to maintenance ICS plus short-acting β 2 -agonist (SABA) reliever at step 2 of its stepwise treatment algorithm. Our aim was to assess the efficacy and safety of these two treatment regimens, with a focus on prevention of severe exacerbation. Methods We performed a systematic review and meta-analysis of all randomised controlled trials (RCTs) comparing as-needed ICS-formoterol with maintenance ICS plus SABA. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrials.gov were searched from database inception to 12 December 2019. The primary outcome was time to first severe exacerbation. RCTs were excluded if they used as-needed budesonide-formoterol as part of a maintenance and reliever regimen, or did not report on severe exacerbations. The review is registered with PROSPERO (identifier number CRD42020154680). Results Four RCTs (n=8065 participants) were included in the analysis. As-needed ICS-formoterol was associated with a prolonged time to first severe exacerbation (hazard ratio 0.85, 95% CI 0.73–1.00; p=0.048) and reduced daily ICS dose (mean difference −177.3 μg, 95% CI −182.2–−172.4 μg). Asthma symptom control was worse in the as-needed group (Asthma Control Questionnaire-5 mean difference 0.12, 95% CI 0.09–0.14), although this did not meet the minimal clinically important difference of 0.50 units. There was no significant difference in serious adverse events (OR 1.07, 95% CI 0.84–1.36). Conclusion As-needed ICS-formoterol offers a therapeutic alternative to maintenance low-dose ICS plus SABA in asthma and may be the preferred option when prevention of severe exacerbation is the primary aim of treatment.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"obyrne-reddel-beasley-themanagementofmildasthma-2021\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'obyrne-reddel-beasley-themanagementofmildasthma-2021', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020', event);\">\n    The management of mild asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  O'Byrne, P. M.; Reddel, H. K.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 57(4): 2003051. April 2021.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020\"\n     onclick=\"log_download('obyrne-reddel-beasley-themanagementofmildasthma-2021', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"The management of mild asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.03051-2020\"\n     onclick=\"log_download('obyrne-reddel-beasley-themanagementofmildasthma-2021', 'http://doi.org/10.1183/13993003.03051-2020', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/obyrne-reddel-beasley-themanagementofmildasthma-2021\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('obyrne-reddel-beasley-themanagementofmildasthma-2021')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{obyrne_management_2021,\n\ttitle = {The management of mild asthma},\n\tvolume = {57},\n\tissn = {0903-1936, 1399-3003},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.03051-2020},\n\tdoi = {10.1183/13993003.03051-2020},\n\tabstract = {Inhaled corticosteroids (ICSs) have been recommended as a maintenance treatment, either alone or together with long-acting inhaled β\n              2\n              -agonists, for all asthma patients. Short-acting β\n              2\n              -agonists (SABAs) are rapid-onset bronchodilators, which provide symptom relief, but have no anti-inflammatory properties, yet are the most widely used as-needed reliever treatment for asthma and often the only treatment prescribed. Asthma patients can find adhering to daily preventative medication with ICS difficult and will often revert to using as-needed SABA as their only treatment, increasing their risk of exacerbations. The purpose of this review is to evaluate the efficacy of reliever medications that contain ICS compared with SABA as reliever, or with maintenance ICS and SABA as reliever, in mild asthma patients.\n            \n            Nine studies were identified that have evaluated the use of ICS as a component of an as-needed reliever in patients with mild asthma. Four of the most recent studies compared the combination of ICS/formoterol to SABA as reliever.\n            ICS-containing reliever medication was superior to SABA as reliever alone, and was equivalent to maintenance ICS and SABA as reliever, particularly in reducing risks of severe asthma exacerbations, in studies which compared these reliever options.\n            SABAs should not be used as a reliever without ICS. The concern about patients with mild asthma not being adherent to maintenance ICS supports a recommendation that ICS/formoterol should be considered as a treatment option instead of maintenance ICS, to avoid the risk of patients reverting to SABA alone.},\n\tlanguage = {en},\n\tnumber = {4},\n\turldate = {2021-04-11},\n\tjournal = {European Respiratory Journal},\n\tauthor = {O&#x27;Byrne, Paul M. and Reddel, Helen K. and Beasley, Richard},\n\tmonth = apr,\n\tyear = {2021},\n\tpages = {2003051},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Inhaled corticosteroids (ICSs) have been recommended as a maintenance treatment, either alone or together with long-acting inhaled β 2 -agonists, for all asthma patients. Short-acting β 2 -agonists (SABAs) are rapid-onset bronchodilators, which provide symptom relief, but have no anti-inflammatory properties, yet are the most widely used as-needed reliever treatment for asthma and often the only treatment prescribed. Asthma patients can find adhering to daily preventative medication with ICS difficult and will often revert to using as-needed SABA as their only treatment, increasing their risk of exacerbations. The purpose of this review is to evaluate the efficacy of reliever medications that contain ICS compared with SABA as reliever, or with maintenance ICS and SABA as reliever, in mild asthma patients. Nine studies were identified that have evaluated the use of ICS as a component of an as-needed reliever in patients with mild asthma. Four of the most recent studies compared the combination of ICS/formoterol to SABA as reliever. ICS-containing reliever medication was superior to SABA as reliever alone, and was equivalent to maintenance ICS and SABA as reliever, particularly in reducing risks of severe asthma exacerbations, in studies which compared these reliever options. SABAs should not be used as a reliever without ICS. The concern about patients with mild asthma not being adherent to maintenance ICS supports a recommendation that ICS/formoterol should be considered as a treatment option instead of maintenance ICS, to avoid the risk of patients reverting to SABA alone.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2020\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2020')\"\n      onkeypress=\"toggleGroup('group_2020')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2020</span>\n      <span class=\"bibbase_group_count\">\n        \n        (16)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"foster-beasley-braithwaite-harrison-holliday-pavord-reddel-patientexperiencesofasneededbudesonideformoterolbyturbuhalerfortreatmentofmildasthmaaqualitativestudy-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'foster-beasley-braithwaite-harrison-holliday-pavord-reddel-patientexperiencesofasneededbudesonideformoterolbyturbuhalerfortreatmentofmildasthmaaqualitativestudy-2020', 'https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948', event);\">\n    Patient experiences of as-needed budesonide-formoterol by Turbuhaler® for treatment of mild asthma; a qualitative study.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Foster, J.; Beasley, R.; Braithwaite, I.; Harrison, T.; Holliday, M.; Pavord, I.;  and Reddel, H.\n</span>\n\n  \n\n</span>\n\n  <i>Respiratory Medicine</i>, 175: 106154. December 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948\"\n     onclick=\"log_download('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-patientexperiencesofasneededbudesonideformoterolbyturbuhalerfortreatmentofmildasthmaaqualitativestudy-2020', 'https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Patient experiences of as-needed budesonide-formoterol by Turbuhaler® for treatment of mild asthma; a qualitative study [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.rmed.2020.106154\"\n     onclick=\"log_download('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-patientexperiencesofasneededbudesonideformoterolbyturbuhalerfortreatmentofmildasthmaaqualitativestudy-2020', 'http://doi.org/10.1016/j.rmed.2020.106154', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/foster-beasley-braithwaite-harrison-holliday-pavord-reddel-patientexperiencesofasneededbudesonideformoterolbyturbuhalerfortreatmentofmildasthmaaqualitativestudy-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-patientexperiencesofasneededbudesonideformoterolbyturbuhalerfortreatmentofmildasthmaaqualitativestudy-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{foster_patient_2020,\n\ttitle = {Patient experiences of as-needed budesonide-formoterol by {Turbuhaler}® for treatment of mild asthma; a qualitative study},\n\tvolume = {175},\n\tissn = {09546111},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0954611120302948},\n\tdoi = {10.1016/j.rmed.2020.106154},\n\tlanguage = {en},\n\turldate = {2021-05-12},\n\tjournal = {Respiratory Medicine},\n\tauthor = {Foster, J.M. and Beasley, R. and Braithwaite, I. and Harrison, T. and Holliday, M. and Pavord, I. and Reddel, H.K.},\n\tmonth = dec,\n\tyear = {2020},\n\tpages = {106154},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-harper-masoli-antiinterleukin5therapyinpatientswithsevereasthmafromclinicaltrialstoclinicalpractice-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-harper-masoli-antiinterleukin5therapyinpatientswithsevereasthmafromclinicaltrialstoclinicalpractice-2020', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515', event);\">\n    Anti-interleukin-5 therapy in patients with severe asthma: from clinical trials to clinical practice.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.; Harper, J.;  and Masoli, M.\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet Respiratory Medicine</i>, 8(5): 425–427. May 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515\"\n     onclick=\"log_download('beasley-harper-masoli-antiinterleukin5therapyinpatientswithsevereasthmafromclinicaltrialstoclinicalpractice-2020', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Anti-interleukin-5 therapy in patients with severe asthma: from clinical trials to clinical practice [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S2213-2600(20)30051-5\"\n     onclick=\"log_download('beasley-harper-masoli-antiinterleukin5therapyinpatientswithsevereasthmafromclinicaltrialstoclinicalpractice-2020', 'http://doi.org/10.1016/S2213-2600(20)30051-5', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-harper-masoli-antiinterleukin5therapyinpatientswithsevereasthmafromclinicaltrialstoclinicalpractice-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-harper-masoli-antiinterleukin5therapyinpatientswithsevereasthmafromclinicaltrialstoclinicalpractice-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_anti-interleukin-5_2020,\n\ttitle = {Anti-interleukin-5 therapy in patients with severe asthma: from clinical trials to clinical practice},\n\tvolume = {8},\n\tissn = {22132600},\n\tshorttitle = {Anti-interleukin-5 therapy in patients with severe asthma},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020300515},\n\tdoi = {10.1016/S2213-2600(20)30051-5},\n\tlanguage = {en},\n\tnumber = {5},\n\turldate = {2021-05-07},\n\tjournal = {The Lancet Respiratory Medicine},\n\tauthor = {Beasley, Richard and Harper, James and Masoli, Matthew},\n\tmonth = may,\n\tyear = {2020},\n\tpages = {425--427},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-gibson-twentyfiveyearsofrespirologyadvancesinasthma-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-gibson-twentyfiveyearsofrespirologyadvancesinasthma-2020', 'https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735', event);\">\n    Twenty‐five years of Respirology: Advances in asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.;  and Gibson, P.\n</span>\n\n  \n\n</span>\n\n  <i>Respirology</i>, 25(1): 11–13. January 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735\"\n     onclick=\"log_download('beasley-gibson-twentyfiveyearsofrespirologyadvancesinasthma-2020', 'https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Twenty‐five years of Respirology: Advances in asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1111/resp.13735\"\n     onclick=\"log_download('beasley-gibson-twentyfiveyearsofrespirologyadvancesinasthma-2020', 'http://doi.org/10.1111/resp.13735', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-gibson-twentyfiveyearsofrespirologyadvancesinasthma-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-gibson-twentyfiveyearsofrespirologyadvancesinasthma-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_twentyfive_2020,\n\ttitle = {Twenty‐five years of {Respirology}: {Advances} in asthma},\n\tvolume = {25},\n\tissn = {1323-7799, 1440-1843},\n\tshorttitle = {Twenty‐five years of \\textit{{Respirology}}},\n\turl = {https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13735},\n\tdoi = {10.1111/resp.13735},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-05-07},\n\tjournal = {Respirology},\n\tauthor = {Beasley, Richard and Gibson, Peter},\n\tmonth = jan,\n\tyear = {2020},\n\tpages = {11--13},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-braithwaite-semprini-kearns-weatherall-harrison-papi-pavord-icsformoterolrelievertherapystepwisetreatmentalgorithmforadultasthma-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-braithwaite-semprini-kearns-weatherall-harrison-papi-pavord-icsformoterolrelievertherapystepwisetreatmentalgorithmforadultasthma-2020', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019', event);\">\n    ICS-formoterol reliever therapy stepwise treatment algorithm for adult asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.; Braithwaite, I.; Semprini, A.; Kearns, C.; Weatherall, M.; Harrison, T. W.; Papi, A.;  and Pavord, I. D.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 55(1): 1901407. January 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019\"\n     onclick=\"log_download('beasley-braithwaite-semprini-kearns-weatherall-harrison-papi-pavord-icsformoterolrelievertherapystepwisetreatmentalgorithmforadultasthma-2020', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"ICS-formoterol reliever therapy stepwise treatment algorithm for adult asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.01407-2019\"\n     onclick=\"log_download('beasley-braithwaite-semprini-kearns-weatherall-harrison-papi-pavord-icsformoterolrelievertherapystepwisetreatmentalgorithmforadultasthma-2020', 'http://doi.org/10.1183/13993003.01407-2019', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-braithwaite-semprini-kearns-weatherall-harrison-papi-pavord-icsformoterolrelievertherapystepwisetreatmentalgorithmforadultasthma-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-braithwaite-semprini-kearns-weatherall-harrison-papi-pavord-icsformoterolrelievertherapystepwisetreatmentalgorithmforadultasthma-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_ics-formoterol_2020,\n\ttitle = {{ICS}-formoterol reliever therapy stepwise treatment algorithm for adult asthma},\n\tvolume = {55},\n\tissn = {0903-1936, 1399-3003},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01407-2019},\n\tdoi = {10.1183/13993003.01407-2019},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-05-07},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Beasley, Richard and Braithwaite, Irene and Semprini, Alex and Kearns, Ciléin and Weatherall, Mark and Harrison, Tim W. and Papi, Alberto and Pavord, Ian D.},\n\tmonth = jan,\n\tyear = {2020},\n\tpages = {1901407},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"baggott-reddel-hardy-sparks-holliday-corin-montgomery-reid-etal-patientpreferencesforsymptomdrivenorregularpreventertreatmentinmildtomoderateasthmafindingsfromthepracticalstudyarandomisedclinicaltrial-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'baggott-reddel-hardy-sparks-holliday-corin-montgomery-reid-etal-patientpreferencesforsymptomdrivenorregularpreventertreatmentinmildtomoderateasthmafindingsfromthepracticalstudyarandomisedclinicaltrial-2020', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019', event);\">\n    Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma: findings from the PRACTICAL study, a randomised clinical trial.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Baggott, C.; Reddel, H. K.; Hardy, J.; Sparks, J.; Holliday, M.; Corin, A.; Montgomery, B.; Reid, J.; Sheahan, D.; Hancox, R. J.; Weatherall, M.; Beasley, R.;  and Fingleton, J.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 55(4): 1902073. April 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019\"\n     onclick=\"log_download('baggott-reddel-hardy-sparks-holliday-corin-montgomery-reid-etal-patientpreferencesforsymptomdrivenorregularpreventertreatmentinmildtomoderateasthmafindingsfromthepracticalstudyarandomisedclinicaltrial-2020', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma: findings from the PRACTICAL study, a randomised clinical trial [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.02073-2019\"\n     onclick=\"log_download('baggott-reddel-hardy-sparks-holliday-corin-montgomery-reid-etal-patientpreferencesforsymptomdrivenorregularpreventertreatmentinmildtomoderateasthmafindingsfromthepracticalstudyarandomisedclinicaltrial-2020', 'http://doi.org/10.1183/13993003.02073-2019', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/baggott-reddel-hardy-sparks-holliday-corin-montgomery-reid-etal-patientpreferencesforsymptomdrivenorregularpreventertreatmentinmildtomoderateasthmafindingsfromthepracticalstudyarandomisedclinicaltrial-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('baggott-reddel-hardy-sparks-holliday-corin-montgomery-reid-etal-patientpreferencesforsymptomdrivenorregularpreventertreatmentinmildtomoderateasthmafindingsfromthepracticalstudyarandomisedclinicaltrial-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{baggott_patient_2020,\n\ttitle = {Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma: findings from the {PRACTICAL} study, a randomised clinical trial},\n\tvolume = {55},\n\tissn = {0903-1936, 1399-3003},\n\tshorttitle = {Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02073-2019},\n\tdoi = {10.1183/13993003.02073-2019},\n\tabstract = {Symptom-driven low-dose inhaled corticosteroid–formoterol is safe and effective in mild asthma and has been recommended as one of the preferred treatment regimens at steps 1 and 2 in the 2019 update of the Global Initiative for Asthma. However, there are no data on patient preferences for this regimen.\n            A subgroup of participants in the PRACTICAL study (ACTRN12616000377437), a randomised controlled trial comparing symptom-driven budesonide–formoterol with maintenance budesonide plus as-needed terbutaline completed a survey on treatment preferences, satisfaction, beliefs and experience at their final study visit.\n            306 (75\\%) out of 407 eligible participants completed the survey. Regimen preference was strongly associated with randomised treatment, as were preferences for and beliefs about preventer inhaler use. Combination preventer and reliever as-needed therapy was preferred by 135 (90\\%, 95\\% CI 85.2–94.8\\%) out of 150 who were randomised to as-needed budesonide–formoterol, and by 63 (40\\%, 95\\% CI 32.7–48.1\\%) out of 156 who were randomised to maintenance budesonide. By contrast, twice-daily preventer inhaler with a reliever inhaler as required was preferred by 15 (10\\%) out of 150 of those randomised to as-needed budesonide–formoterol and 93 (60\\%) out of 156 of those randomised to maintenance budesonide. Satisfaction with all study inhalers was high. Of patients randomised to as-needed budesonide–formoterol 92\\% (n=138) were confident using it as a reliever at the end of the study.\n            Although most participants preferred the regimen to which they had been randomised, this association was much stronger for those randomised to budesonide–formoterol as needed, indicating that most patients preferred as-needed corticosteroid–formoterol therapy if they had experienced it.},\n\tlanguage = {en},\n\tnumber = {4},\n\turldate = {2021-05-07},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Baggott, Christina and Reddel, Helen K. and Hardy, Jo and Sparks, Jenny and Holliday, Mark and Corin, Andrew and Montgomery, Barney and Reid, Jim and Sheahan, Davitt and Hancox, Robert J. and Weatherall, Mark and Beasley, Richard and Fingleton, James},\n\tmonth = apr,\n\tyear = {2020},\n\tpages = {1902073},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Symptom-driven low-dose inhaled corticosteroid–formoterol is safe and effective in mild asthma and has been recommended as one of the preferred treatment regimens at steps 1 and 2 in the 2019 update of the Global Initiative for Asthma. However, there are no data on patient preferences for this regimen. A subgroup of participants in the PRACTICAL study (ACTRN12616000377437), a randomised controlled trial comparing symptom-driven budesonide–formoterol with maintenance budesonide plus as-needed terbutaline completed a survey on treatment preferences, satisfaction, beliefs and experience at their final study visit. 306 (75%) out of 407 eligible participants completed the survey. Regimen preference was strongly associated with randomised treatment, as were preferences for and beliefs about preventer inhaler use. Combination preventer and reliever as-needed therapy was preferred by 135 (90%, 95% CI 85.2–94.8%) out of 150 who were randomised to as-needed budesonide–formoterol, and by 63 (40%, 95% CI 32.7–48.1%) out of 156 who were randomised to maintenance budesonide. By contrast, twice-daily preventer inhaler with a reliever inhaler as required was preferred by 15 (10%) out of 150 of those randomised to as-needed budesonide–formoterol and 93 (60%) out of 156 of those randomised to maintenance budesonide. Satisfaction with all study inhalers was high. Of patients randomised to as-needed budesonide–formoterol 92% (n=138) were confident using it as a reliever at the end of the study. Although most participants preferred the regimen to which they had been randomised, this association was much stronger for those randomised to budesonide–formoterol as needed, indicating that most patients preferred as-needed corticosteroid–formoterol therapy if they had experienced it.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"baggott-hansen-hancox-hardy-sparks-holliday-weatherall-beasley-etal-whatmattersmosttopatientswhenchoosingtreatmentformildmoderateasthmaresultsfromadiscretechoiceexperiment-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'baggott-hansen-hancox-hardy-sparks-holliday-weatherall-beasley-etal-whatmattersmosttopatientswhenchoosingtreatmentformildmoderateasthmaresultsfromadiscretechoiceexperiment-2020', 'https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343', event);\">\n    What matters most to patients when choosing treatment for mild–moderate asthma? Results from a discrete choice experiment.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Baggott, C.; Hansen, P.; Hancox, R. J; Hardy, J. K.; Sparks, J.; Holliday, M.; Weatherall, M.; Beasley, R.; Reddel, H. K;  and Fingleton, J.\n</span>\n\n  \n\n</span>\n\n  <i>Thorax</i>, 75(10): 842–848. October 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343\"\n     onclick=\"log_download('baggott-hansen-hancox-hardy-sparks-holliday-weatherall-beasley-etal-whatmattersmosttopatientswhenchoosingtreatmentformildmoderateasthmaresultsfromadiscretechoiceexperiment-2020', 'https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"What matters most to patients when choosing treatment for mild–moderate asthma? Results from a discrete choice experiment [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1136/thoraxjnl-2019-214343\"\n     onclick=\"log_download('baggott-hansen-hancox-hardy-sparks-holliday-weatherall-beasley-etal-whatmattersmosttopatientswhenchoosingtreatmentformildmoderateasthmaresultsfromadiscretechoiceexperiment-2020', 'http://doi.org/10.1136/thoraxjnl-2019-214343', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/baggott-hansen-hancox-hardy-sparks-holliday-weatherall-beasley-etal-whatmattersmosttopatientswhenchoosingtreatmentformildmoderateasthmaresultsfromadiscretechoiceexperiment-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('baggott-hansen-hancox-hardy-sparks-holliday-weatherall-beasley-etal-whatmattersmosttopatientswhenchoosingtreatmentformildmoderateasthmaresultsfromadiscretechoiceexperiment-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{baggott_what_2020,\n\ttitle = {What matters most to patients when choosing treatment for mild–moderate asthma? {Results} from a discrete choice experiment},\n\tvolume = {75},\n\tissn = {0040-6376, 1468-3296},\n\tshorttitle = {What matters most to patients when choosing treatment for mild–moderate asthma?},\n\turl = {https://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2019-214343},\n\tdoi = {10.1136/thoraxjnl-2019-214343},\n\tabstract = {Background\n              An as-needed combination preventer and reliever regimen was recently introduced as an alternative to conventional daily preventer treatment for mild asthma. In a subgroup analysis of the PRACTICAL study, a pragmatic randomised controlled trial of budesonide–formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild asthma, we recently reported that about two-thirds preferred as-needed combination preventer and reliever therapy. The aim of this study was to determine the relative importance of attributes associated with these two asthma therapies in this subgroup of participants who indicated their preferred treatment in the PRACTICAL study.\n            \n            \n              Methods\n              At their final study visit, a subgroup of participants indicated their preferred treatment and completed a discrete choice experiment using the Potentially All Pairwise RanKings of all possible Alternatives method and 1000minds software. Treatment attributes and their levels were selected from measurable study outcomes, and included: treatment regimen, shortness of breath, steroid dose and likelihood of asthma flare-up.\n            \n            \n              Results\n              The final analysis dataset included 288 participants, 64\\% of whom preferred as-needed combination preventer and reliever. Of the attributes, no shortness of breath and lowest risk of asthma flare-up were ranked highest and second highest, respectively. However, the relative importance of the other two attributes varied by preferred therapy: treatment regimen was ranked higher by participants who preferred as-needed treatment than by participants who preferred maintenance treatment.\n            \n            \n              Conclusions\n              Knowledge of patient preferences for treatment attributes together with regimen characteristics can be used in shared decision-making regarding choice of treatment for patients with mild–moderate asthma.\n            \n            \n              Trial registration number\n              ACTRN12616000377437.},\n\tlanguage = {en},\n\tnumber = {10},\n\turldate = {2021-05-05},\n\tjournal = {Thorax},\n\tauthor = {Baggott, Christina and Hansen, Paul and Hancox, Robert J and Hardy, Jo Katherine and Sparks, Jenny and Holliday, Mark and Weatherall, Mark and Beasley, Richard and Reddel, Helen K and Fingleton, James},\n\tmonth = oct,\n\tyear = {2020},\n\tpages = {842--848},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Background An as-needed combination preventer and reliever regimen was recently introduced as an alternative to conventional daily preventer treatment for mild asthma. In a subgroup analysis of the PRACTICAL study, a pragmatic randomised controlled trial of budesonide–formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild asthma, we recently reported that about two-thirds preferred as-needed combination preventer and reliever therapy. The aim of this study was to determine the relative importance of attributes associated with these two asthma therapies in this subgroup of participants who indicated their preferred treatment in the PRACTICAL study. Methods At their final study visit, a subgroup of participants indicated their preferred treatment and completed a discrete choice experiment using the Potentially All Pairwise RanKings of all possible Alternatives method and 1000minds software. Treatment attributes and their levels were selected from measurable study outcomes, and included: treatment regimen, shortness of breath, steroid dose and likelihood of asthma flare-up. Results The final analysis dataset included 288 participants, 64% of whom preferred as-needed combination preventer and reliever. Of the attributes, no shortness of breath and lowest risk of asthma flare-up were ranked highest and second highest, respectively. However, the relative importance of the other two attributes varied by preferred therapy: treatment regimen was ranked higher by participants who preferred as-needed treatment than by participants who preferred maintenance treatment. Conclusions Knowledge of patient preferences for treatment attributes together with regimen characteristics can be used in shared decision-making regarding choice of treatment for patients with mild–moderate asthma. Trial registration number ACTRN12616000377437.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"hardy-tewhaitismith-baggott-fingleton-semprini-holliday-hancox-weatherall-etal-combinationbudesonideformoterolinhalerassolerelievertherapyinmoriandpacificpeoplewithmildandmoderateasthma-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Combination budesonide/formoterol inhaler as sole reliever therapy in Māori and Pacific people with mild and moderate asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Hardy, J.; Tewhaiti-Smith, J.; Baggott, C.; Fingleton, J.; Semprini, A.; Holliday, M.; Hancox, R. J.; Weatherall, M.;  and Harwood, M.\n</span>\n\n  \n\n</span>\n\n  <i>The New Zealand Medical Journal</i>, 133(1520): 61–72. August 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/hardy-tewhaitismith-baggott-fingleton-semprini-holliday-hancox-weatherall-etal-combinationbudesonideformoterolinhalerassolerelievertherapyinmoriandpacificpeoplewithmildandmoderateasthma-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('hardy-tewhaitismith-baggott-fingleton-semprini-holliday-hancox-weatherall-etal-combinationbudesonideformoterolinhalerassolerelievertherapyinmoriandpacificpeoplewithmildandmoderateasthma-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{hardy_combination_2020,\n\ttitle = {Combination budesonide/formoterol inhaler as sole reliever therapy in {Māori} and {Pacific} people with mild and moderate asthma},\n\tvolume = {133},\n\tissn = {1175-8716},\n\tabstract = {AIM: In the PRACTICAL study, as-needed budesonide/formoterol reduced the rate of severe exacerbations compared with maintenance budesonide plus as-needed terbutaline. In a pre-specified analysis we analysed the efficacy in Māori and Pacific peoples, populations with worse asthma outcomes.\nMETHOD: The PRACTICAL study was a 52-week, open-label, parallel group, randomised controlled trial of 890 adults with mild to moderate asthma, who were randomised to budesonide/formoterol Turbuhaler 200/6mcg one actuation as required or budesonide Turbuhaler 200mcg one actuation twice daily and terbutaline Turbuhaler 250mcg two actuations as required. The primary outcome was rate of severe exacerbations. The analysis strategy was to test an ethnicity-treatment interaction term for each outcome variable.\nRESULTS: Seventy-two participants (8\\%) identified as Māori, 36 participants (4\\%) as Pacific ethnicity. There was no evidence that ethnicity was an effect modifier for severe exacerbations (P interaction 0.70).\nCONCLUSION: The reduction in severe exacerbation risk with budesonide-formoterol reliever compared with maintenance budesonide was similar in Māori and Pacific adults compared with New Zealand European/Other.},\n\tlanguage = {eng},\n\tnumber = {1520},\n\tjournal = {The New Zealand Medical Journal},\n\tauthor = {Hardy, Jo and Tewhaiti-Smith, Jordan and Baggott, Christina and Fingleton, James and Semprini, Alex and Holliday, Mark and Hancox, Robert J. and Weatherall, Mark and Harwood, Matire},\n\tmonth = aug,\n\tyear = {2020},\n\tpmid = {32994594},\n\tkeywords = {Administration, Inhalation, Adult, Anti-Asthmatic Agents, Asthma, Bronchodilator Agents, Budesonide, Budesonide, Formoterol Fumarate Drug Combination, Case-Control Studies, Disease Progression, Drug Therapy, Combination, Ethnic Groups, Female, Humans, Male, Middle Aged, Nebulizers and Vaporizers, New Zealand, Outcome Assessment, Health Care, Terbutaline, Treatment Outcome},\n\tpages = {61--72},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  AIM: In the PRACTICAL study, as-needed budesonide/formoterol reduced the rate of severe exacerbations compared with maintenance budesonide plus as-needed terbutaline. In a pre-specified analysis we analysed the efficacy in Māori and Pacific peoples, populations with worse asthma outcomes. METHOD: The PRACTICAL study was a 52-week, open-label, parallel group, randomised controlled trial of 890 adults with mild to moderate asthma, who were randomised to budesonide/formoterol Turbuhaler 200/6mcg one actuation as required or budesonide Turbuhaler 200mcg one actuation twice daily and terbutaline Turbuhaler 250mcg two actuations as required. The primary outcome was rate of severe exacerbations. The analysis strategy was to test an ethnicity-treatment interaction term for each outcome variable. RESULTS: Seventy-two participants (8%) identified as Māori, 36 participants (4%) as Pacific ethnicity. There was no evidence that ethnicity was an effect modifier for severe exacerbations (P interaction 0.70). CONCLUSION: The reduction in severe exacerbation risk with budesonide-formoterol reliever compared with maintenance budesonide was similar in Māori and Pacific adults compared with New Zealand European/Other.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"baggott-chan-hurford-fingleton-beasley-harwood-reddel-levack-patientpreferencesforasthmamanagementaqualitativestudy-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'baggott-chan-hurford-fingleton-beasley-harwood-reddel-levack-patientpreferencesforasthmamanagementaqualitativestudy-2020', 'http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491', event);\">\n    Patient preferences for asthma management: a qualitative study.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Baggott, C.; Chan, A.; Hurford, S.; Fingleton, J.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Harwood, M.; Reddel, H. K;  and Levack, W. M. M.\n</span>\n\n  \n\n</span>\n\n  <i>BMJ Open</i>, 10(8): e037491. August 2020.\n  <span class=\"note\">Number: 8</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491\"\n     onclick=\"log_download('baggott-chan-hurford-fingleton-beasley-harwood-reddel-levack-patientpreferencesforasthmamanagementaqualitativestudy-2020', 'http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Patient preferences for asthma management: a qualitative study [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1136/bmjopen-2020-037491\"\n     onclick=\"log_download('baggott-chan-hurford-fingleton-beasley-harwood-reddel-levack-patientpreferencesforasthmamanagementaqualitativestudy-2020', 'http://doi.org/10.1136/bmjopen-2020-037491', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/baggott-chan-hurford-fingleton-beasley-harwood-reddel-levack-patientpreferencesforasthmamanagementaqualitativestudy-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('baggott-chan-hurford-fingleton-beasley-harwood-reddel-levack-patientpreferencesforasthmamanagementaqualitativestudy-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{baggott_patient_2020-1,\n\ttitle = {Patient preferences for asthma management: a qualitative study},\n\tvolume = {10},\n\tissn = {2044-6055, 2044-6055},\n\tshorttitle = {Patient preferences for asthma management},\n\turl = {http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-037491},\n\tdoi = {10.1136/bmjopen-2020-037491},\n\tabstract = {Objective\n              Preference for asthma management and the use of medications is motivated by the interplay between lived experiences of asthma and patients’ attitudes towards medications. Many previous studies have focused on individual aspects of asthma management, such as the use of preventer and reliever inhalers. The aim of this qualitative study was to explore the preferences of patients with mild-moderate asthma for asthma management as a whole and factors that influenced these preferences.\n            \n            \n              Design\n              A qualitative study employing qualitative descriptive analysis situated within a constructionist epistemology to analyse transcribed audio recordings from focus groups.\n            \n            \n              Setting\n              Three locations within the greater Wellington area in New Zealand.\n            \n            \n              Participants\n              \n                Twenty-seven adults with self-reported doctor’s diagnosis of asthma, taking short-acting beta-agonists alone or inhaled corticosteroids with or without long-acting beta\n                2\n                -agonist, who had used any inhaled asthma medication within the last month.\n              \n            \n            \n              Results\n              Four key areas described preferences for asthma management. Preferences for self-management: participants wanted to be in control of their asthma and developed personal strategies to achieve this. Preferences for the specific medications or treatment regimen: participants preferred regimens that were convenient and reliably relieved symptoms. Preferences for inhaler devices: devices that had dose counters and were easy to use and portable were important. Preferences for asthma services: participants wanted easier access to their inhalers and to be empowered by their healthcare providers. Participant preferences within each of these four areas were influenced by the impact asthma had on their life, their health beliefs, emotional consequences of asthma and perceived barriers to asthma management.\n            \n            \n              Conclusions\n              This study illustrates the interaction of the lived experience of asthma, factors specific to the individual, and factors relating to asthma treatments in shaping patient preferences for asthma management. This aids our understanding of preferences for asthma management from the patient perspective.\n            \n            \n              Trial registration number\n              Australian New Zealand Clinical Trials Registry (ACTRN12619000601134).},\n\tlanguage = {en},\n\tnumber = {8},\n\turldate = {2020-09-03},\n\tjournal = {BMJ Open},\n\tauthor = {Baggott, Christina and Chan, Amy and Hurford, Sally and Fingleton, James and Beasley, Richard and Harwood, Matire and Reddel, Helen K and Levack, William Mark Magnus},\n\tmonth = aug,\n\tyear = {2020},\n\tnote = {Number: 8},\n\tpages = {e037491},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objective Preference for asthma management and the use of medications is motivated by the interplay between lived experiences of asthma and patients’ attitudes towards medications. Many previous studies have focused on individual aspects of asthma management, such as the use of preventer and reliever inhalers. The aim of this qualitative study was to explore the preferences of patients with mild-moderate asthma for asthma management as a whole and factors that influenced these preferences. Design A qualitative study employing qualitative descriptive analysis situated within a constructionist epistemology to analyse transcribed audio recordings from focus groups. Setting Three locations within the greater Wellington area in New Zealand. Participants Twenty-seven adults with self-reported doctor’s diagnosis of asthma, taking short-acting beta-agonists alone or inhaled corticosteroids with or without long-acting beta 2 -agonist, who had used any inhaled asthma medication within the last month. Results Four key areas described preferences for asthma management. Preferences for self-management: participants wanted to be in control of their asthma and developed personal strategies to achieve this. Preferences for the specific medications or treatment regimen: participants preferred regimens that were convenient and reliably relieved symptoms. Preferences for inhaler devices: devices that had dose counters and were easy to use and portable were important. Preferences for asthma services: participants wanted easier access to their inhalers and to be empowered by their healthcare providers. Participant preferences within each of these four areas were influenced by the impact asthma had on their life, their health beliefs, emotional consequences of asthma and perceived barriers to asthma management. Conclusions This study illustrates the interaction of the lived experience of asthma, factors specific to the individual, and factors relating to asthma treatments in shaping patient preferences for asthma management. This aids our understanding of preferences for asthma management from the patient perspective. Trial registration number Australian New Zealand Clinical Trials Registry (ACTRN12619000601134).\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"baggott-hardy-sparks-holliday-hall-vohlidkova-hancox-weatherall-etal-selftitrationofinhaledcorticosteroidand2agonistinresponsetosymptomsinmildasthmaaprespecifiedanalysisfromthepracticalrandomisedcontrolledtrial-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'baggott-hardy-sparks-holliday-hall-vohlidkova-hancox-weatherall-etal-selftitrationofinhaledcorticosteroidand2agonistinresponsetosymptomsinmildasthmaaprespecifiedanalysisfromthepracticalrandomisedcontrolledtrial-2020', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020', event);\">\n    Self-titration of inhaled corticosteroid and β2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Baggott, C.; Hardy, J.; Sparks, J.; Holliday, M.; Hall, D.; Vohlidkova, A.; Hancox, R. J.; Weatherall, M.; Fingleton, J.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 56(4): 2000170. October 2020.\n  <span class=\"note\">Number: 4</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020\"\n     onclick=\"log_download('baggott-hardy-sparks-holliday-hall-vohlidkova-hancox-weatherall-etal-selftitrationofinhaledcorticosteroidand2agonistinresponsetosymptomsinmildasthmaaprespecifiedanalysisfromthepracticalrandomisedcontrolledtrial-2020', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Self-titration of inhaled corticosteroid and β2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.00170-2020\"\n     onclick=\"log_download('baggott-hardy-sparks-holliday-hall-vohlidkova-hancox-weatherall-etal-selftitrationofinhaledcorticosteroidand2agonistinresponsetosymptomsinmildasthmaaprespecifiedanalysisfromthepracticalrandomisedcontrolledtrial-2020', 'http://doi.org/10.1183/13993003.00170-2020', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/baggott-hardy-sparks-holliday-hall-vohlidkova-hancox-weatherall-etal-selftitrationofinhaledcorticosteroidand2agonistinresponsetosymptomsinmildasthmaaprespecifiedanalysisfromthepracticalrandomisedcontrolledtrial-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('baggott-hardy-sparks-holliday-hall-vohlidkova-hancox-weatherall-etal-selftitrationofinhaledcorticosteroidand2agonistinresponsetosymptomsinmildasthmaaprespecifiedanalysisfromthepracticalrandomisedcontrolledtrial-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{baggott_self-titration_2020,\n\ttitle = {Self-titration of inhaled corticosteroid and β2-agonist in response to symptoms in mild asthma: a pre-specified analysis from the {PRACTICAL} randomised controlled trial},\n\tvolume = {56},\n\tissn = {0903-1936, 1399-3003},\n\tshorttitle = {Self-titration of inhaled corticosteroid and β $_{\\textrm{2}}$ -agonist in response to symptoms in mild asthma},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00170-2020},\n\tdoi = {10.1183/13993003.00170-2020},\n\tabstract = {Introduction\n              \n                In mild asthma, as-needed budesonide–formoterol is superior or noninferior to maintenance budesonide plus as-needed short-acting β\n                2\n                -agonist in reducing severe exacerbations. In this pre-specified analysis, we investigated patterns of inhaled corticosteroid (ICS) and β\n                2\n                -agonist use in PRACTICAL, a randomised controlled trial.\n              \n            \n            \n              Methods\n              \n                Participants were randomised 1:1 to as-needed budesonide–formoterol (200/6 μg Turbuhaler, one actuation) or maintenance budesonide (200 μg Turbuhaler, one actuation twice a day) with as-needed terbutaline (250 μg, two actuations) for 52 weeks. 110 participants had electronic monitors attached to their study inhalers which captured the time and date of every actuation. Key outcome measures were patterns of ICS and β\n                2\n                -agonist use. One actuation of budesonide–formoterol was considered to be an equivalent bronchodilator dose as two actuations of terbutaline.\n              \n            \n            \n              Results\n              \n                Participants randomised to as-needed budesonide–formoterol had more days with no ICS use compared with maintenance budesonide (median total days of no use 156\n                versus\n                22 days, respectively), lower median daily budesonide dose (164\n                versus\n                328 μg, respectively) and a greater median number of days of ≥4 budesonide actuations (4\n                versus\n                1 days, respectively). Participants randomised to as-needed budesonide–formoterol took higher equivalent doses of β\n                2\n                -agonist both overall (median number of actuations 0.8\n                versus\n                0.3 per day, respectively) and in response to worsening asthma (total number of “overuse days” of {\\textgreater}8 or {\\textgreater}16 actuations of budesonide–formoterol or terbutaline 33\n                versus\n                10 days, respectively).\n              \n            \n            \n              Conclusions\n              \n                The timing of ICS dose when self-titrated to β\n                2\n                -agonist use is more important than total ICS dose in reducing severe exacerbation risk in mild asthma, when associated with greater overall use of as-needed β\n                2\n                -agonist.},\n\tlanguage = {en},\n\tnumber = {4},\n\turldate = {2020-10-13},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Baggott, Christina and Hardy, Jo and Sparks, Jenny and Holliday, Mark and Hall, Daniela and Vohlidkova, Alexandra and Hancox, Robert J. and Weatherall, Mark and Fingleton, James and Beasley, Richard},\n\tmonth = oct,\n\tyear = {2020},\n\tnote = {Number: 4},\n\tpages = {2000170},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Introduction In mild asthma, as-needed budesonide–formoterol is superior or noninferior to maintenance budesonide plus as-needed short-acting β 2 -agonist in reducing severe exacerbations. In this pre-specified analysis, we investigated patterns of inhaled corticosteroid (ICS) and β 2 -agonist use in PRACTICAL, a randomised controlled trial. Methods Participants were randomised 1:1 to as-needed budesonide–formoterol (200/6 μg Turbuhaler, one actuation) or maintenance budesonide (200 μg Turbuhaler, one actuation twice a day) with as-needed terbutaline (250 μg, two actuations) for 52 weeks. 110 participants had electronic monitors attached to their study inhalers which captured the time and date of every actuation. Key outcome measures were patterns of ICS and β 2 -agonist use. One actuation of budesonide–formoterol was considered to be an equivalent bronchodilator dose as two actuations of terbutaline. Results Participants randomised to as-needed budesonide–formoterol had more days with no ICS use compared with maintenance budesonide (median total days of no use 156 versus 22 days, respectively), lower median daily budesonide dose (164 versus 328 μg, respectively) and a greater median number of days of ≥4 budesonide actuations (4 versus 1 days, respectively). Participants randomised to as-needed budesonide–formoterol took higher equivalent doses of β 2 -agonist both overall (median number of actuations 0.8 versus 0.3 per day, respectively) and in response to worsening asthma (total number of “overuse days” of \\textgreater8 or \\textgreater16 actuations of budesonide–formoterol or terbutaline 33 versus 10 days, respectively). Conclusions The timing of ICS dose when self-titrated to β 2 -agonist use is more important than total ICS dose in reducing severe exacerbation risk in mild asthma, when associated with greater overall use of as-needed β 2 -agonist.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"kearns-maijers-harper-beasley-weatherall-inhaledcorticosteroidsinacuteasthmaasystemicreviewandmetaanalysis-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'kearns-maijers-harper-beasley-weatherall-inhaledcorticosteroidsinacuteasthmaasystemicreviewandmetaanalysis-2020', 'https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767', event);\">\n    Inhaled Corticosteroids in Acute Asthma: A Systemic Review and Meta-Analysis.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Kearns, N.; Maijers, I.; Harper, J.; Beasley, R.;  and Weatherall, M.\n</span>\n\n  \n\n</span>\n\n  <i>The Journal of Allergy and Clinical Immunology: In Practice</i>, 8(2): 605–617.e6. February 2020.\n  <span class=\"note\">Number: 2</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767\"\n     onclick=\"log_download('kearns-maijers-harper-beasley-weatherall-inhaledcorticosteroidsinacuteasthmaasystemicreviewandmetaanalysis-2020', 'https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Inhaled Corticosteroids in Acute Asthma: A Systemic Review and Meta-Analysis [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaip.2019.08.051\"\n     onclick=\"log_download('kearns-maijers-harper-beasley-weatherall-inhaledcorticosteroidsinacuteasthmaasystemicreviewandmetaanalysis-2020', 'http://doi.org/10.1016/j.jaip.2019.08.051', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/kearns-maijers-harper-beasley-weatherall-inhaledcorticosteroidsinacuteasthmaasystemicreviewandmetaanalysis-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('kearns-maijers-harper-beasley-weatherall-inhaledcorticosteroidsinacuteasthmaasystemicreviewandmetaanalysis-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{kearns_inhaled_2020,\n\ttitle = {Inhaled {Corticosteroids} in {Acute} {Asthma}: {A} {Systemic} {Review} and {Meta}-{Analysis}},\n\tvolume = {8},\n\tissn = {22132198},\n\tshorttitle = {Inhaled {Corticosteroids} in {Acute} {Asthma}},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213219819307767},\n\tdoi = {10.1016/j.jaip.2019.08.051},\n\tlanguage = {en},\n\tnumber = {2},\n\turldate = {2020-09-28},\n\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\n\tauthor = {Kearns, Nethmi and Maijers, Ingrid and Harper, James and Beasley, Richard and Weatherall, Mark},\n\tmonth = feb,\n\tyear = {2020},\n\tnote = {Number: 2},\n\tpages = {605--617.e6},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-hancox-reducingtheburdenofasthmatimetosetresearchandclinicalpriorities-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-hancox-reducingtheburdenofasthmatimetosetresearchandclinicalpriorities-2020', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008', event);\">\n    Reducing the burden of asthma: time to set research and clinical priorities.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>;  and Hancox, R. J\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet Respiratory Medicine</i>,S2213260020304008. September 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008\"\n     onclick=\"log_download('beasley-hancox-reducingtheburdenofasthmatimetosetresearchandclinicalpriorities-2020', 'https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Reducing the burden of asthma: time to set research and clinical priorities [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S2213-2600(20)30400-8\"\n     onclick=\"log_download('beasley-hancox-reducingtheburdenofasthmatimetosetresearchandclinicalpriorities-2020', 'http://doi.org/10.1016/S2213-2600(20)30400-8', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-hancox-reducingtheburdenofasthmatimetosetresearchandclinicalpriorities-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-hancox-reducingtheburdenofasthmatimetosetresearchandclinicalpriorities-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_reducing_2020,\n\ttitle = {Reducing the burden of asthma: time to set research and clinical priorities},\n\tissn = {22132600},\n\tshorttitle = {Reducing the burden of asthma},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2213260020304008},\n\tdoi = {10.1016/S2213-2600(20)30400-8},\n\tlanguage = {en},\n\turldate = {2020-09-11},\n\tjournal = {The Lancet Respiratory Medicine},\n\tauthor = {Beasley, Richard and Hancox, Robert J},\n\tmonth = sep,\n\tyear = {2020},\n\tpages = {S2213260020304008},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"boudewijn-lan-faiz-cox-brouwer-schokker-vroegop-nawijn-etal-nasalgeneexpressionchangeswithinhaledcorticosteroidtreatmentinasthma-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Nasal gene expression changes with inhaled corticosteroid treatment in asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Boudewijn, I. M.; Lan, A.; Faiz, A.; Cox, C. A.; Brouwer, S.; Schokker, S.; Vroegop, S. J.; Nawijn, M. C.; Woodruff, P. G.; Christenson, S. A.; Hagedoorn, P.; Frijlink, H. W.; Choy, D. F.; Brouwer, U.; Wisman, M.; Postma, D. S.; Fingleton, J.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; van den Berge, M.;  and Guryev, V.\n</span>\n\n  \n\n</span>\n\n  <i>Allergy</i>, 75(1): 191–194.  2020.\n  <span class=\"note\">Number: 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1111/all.13952\"\n     onclick=\"log_download('boudewijn-lan-faiz-cox-brouwer-schokker-vroegop-nawijn-etal-nasalgeneexpressionchangeswithinhaledcorticosteroidtreatmentinasthma-2020', 'http://doi.org/10.1111/all.13952', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/boudewijn-lan-faiz-cox-brouwer-schokker-vroegop-nawijn-etal-nasalgeneexpressionchangeswithinhaledcorticosteroidtreatmentinasthma-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('boudewijn-lan-faiz-cox-brouwer-schokker-vroegop-nawijn-etal-nasalgeneexpressionchangeswithinhaledcorticosteroidtreatmentinasthma-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{boudewijn_nasal_2020,\n\ttitle = {Nasal gene expression changes with inhaled corticosteroid treatment in asthma},\n\tvolume = {75},\n\tissn = {1398-9995},\n\tdoi = {10.1111/all.13952},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Allergy},\n\tauthor = {Boudewijn, Ilse M. and Lan, Andy and Faiz, Alen and Cox, Claire A. and Brouwer, Sharon and Schokker, Siebrig and Vroegop, Sebastiaan J. and Nawijn, Martijn C. and Woodruff, Prescott G. and Christenson, Stephanie A. and Hagedoorn, Paul and Frijlink, Henderik W. and Choy, David F. and Brouwer, Uilke and Wisman, Marissa and Postma, Dirkje S. and Fingleton, James and Beasley, Richard and van den Berge, Maarten and Guryev, Victor},\n\tyear = {2020},\n\tpmid = {31230369},\n\tnote = {Number: 1},\n\tpages = {191--194},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"bruce-hatter-beasley-antiinflammatoryrelievertherapyinasthmatheevidencemountsbutmoreisneeded-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13889\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'bruce-hatter-beasley-antiinflammatoryrelievertherapyinasthmatheevidencemountsbutmoreisneeded-2020', 'https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13889', event);\">\n    Anti‐inflammatory reliever therapy in asthma: The evidence mounts but more is needed.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Bruce, P.; Hatter, L.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Respirology</i>, 25(8): 776–778. August 2020.\n  <span class=\"note\">Number: 8</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13889\"\n     onclick=\"log_download('bruce-hatter-beasley-antiinflammatoryrelievertherapyinasthmatheevidencemountsbutmoreisneeded-2020', 'https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13889', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Anti‐inflammatory reliever therapy in asthma: The evidence mounts but more is needed [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1111/resp.13889\"\n     onclick=\"log_download('bruce-hatter-beasley-antiinflammatoryrelievertherapyinasthmatheevidencemountsbutmoreisneeded-2020', 'http://doi.org/10.1111/resp.13889', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/bruce-hatter-beasley-antiinflammatoryrelievertherapyinasthmatheevidencemountsbutmoreisneeded-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('bruce-hatter-beasley-antiinflammatoryrelievertherapyinasthmatheevidencemountsbutmoreisneeded-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{bruce_antiinflammatory_2020,\n\ttitle = {Anti‐inflammatory reliever therapy in asthma: {The} evidence mounts but more is needed},\n\tvolume = {25},\n\tissn = {1323-7799, 1440-1843},\n\tshorttitle = {Anti‐inflammatory reliever therapy in asthma},\n\turl = {https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13889},\n\tdoi = {10.1111/resp.13889},\n\tlanguage = {en},\n\tnumber = {8},\n\turldate = {2020-07-15},\n\tjournal = {Respirology},\n\tauthor = {Bruce, Pepa and Hatter, Lee and Beasley, Richard},\n\tmonth = aug,\n\tyear = {2020},\n\tnote = {Number: 8},\n\tpages = {776--778},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"hills-beasley-thehistoryandfutureofshortactingbeta2agonisttherapyinasthma-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13727\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'hills-beasley-thehistoryandfutureofshortactingbeta2agonisttherapyinasthma-2020', 'https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13727', event);\">\n    The history and future of short‐acting beta 2 ‐agonist therapy in asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Hills, T.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Respirology</i>, 25(3): 246–248. March 2020.\n  <span class=\"note\">Number: 3</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13727\"\n     onclick=\"log_download('hills-beasley-thehistoryandfutureofshortactingbeta2agonisttherapyinasthma-2020', 'https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13727', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"The history and future of short‐acting beta 2 ‐agonist therapy in asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1111/resp.13727\"\n     onclick=\"log_download('hills-beasley-thehistoryandfutureofshortactingbeta2agonisttherapyinasthma-2020', 'http://doi.org/10.1111/resp.13727', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/hills-beasley-thehistoryandfutureofshortactingbeta2agonisttherapyinasthma-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('hills-beasley-thehistoryandfutureofshortactingbeta2agonisttherapyinasthma-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{hills_history_2020,\n\ttitle = {The history and future of short‐acting beta 2 ‐agonist therapy in asthma},\n\tvolume = {25},\n\tissn = {1323-7799},\n\turl = {https://onlinelibrary.wiley.com/doi/abs/10.1111/resp.13727},\n\tdoi = {10.1111/resp.13727},\n\tnumber = {3},\n\tjournal = {Respirology},\n\tauthor = {Hills, Thomas and Beasley, Richard},\n\tmonth = mar,\n\tyear = {2020},\n\tnote = {Number: 3},\n\tpages = {246--248},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"maijers-kearns-harper-weatherall-beasley-oralsteroidsparingeffectofhighdoseinhaledcorticosteroidsinasthma-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01147-2019\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'maijers-kearns-harper-weatherall-beasley-oralsteroidsparingeffectofhighdoseinhaledcorticosteroidsinasthma-2020', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01147-2019', event);\">\n    Oral steroid-sparing effect of high-dose inhaled corticosteroids in asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Maijers, I.; Kearns, N.; Harper, J.; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 55(1): 1901147. January 2020.\n  <span class=\"note\">Number: 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01147-2019\"\n     onclick=\"log_download('maijers-kearns-harper-weatherall-beasley-oralsteroidsparingeffectofhighdoseinhaledcorticosteroidsinasthma-2020', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01147-2019', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Oral steroid-sparing effect of high-dose inhaled corticosteroids in asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.01147-2019\"\n     onclick=\"log_download('maijers-kearns-harper-weatherall-beasley-oralsteroidsparingeffectofhighdoseinhaledcorticosteroidsinasthma-2020', 'http://doi.org/10.1183/13993003.01147-2019', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/maijers-kearns-harper-weatherall-beasley-oralsteroidsparingeffectofhighdoseinhaledcorticosteroidsinasthma-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('maijers-kearns-harper-weatherall-beasley-oralsteroidsparingeffectofhighdoseinhaledcorticosteroidsinasthma-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{maijers_oral_2020,\n\ttitle = {Oral steroid-sparing effect of high-dose inhaled corticosteroids in asthma},\n\tvolume = {55},\n\tissn = {0903-1936},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.01147-2019},\n\tdoi = {10.1183/13993003.01147-2019},\n\tnumber = {1},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Maijers, Ingrid and Kearns, Nethmi and Harper, James and Weatherall, Mark and Beasley, Richard},\n\tmonth = jan,\n\tyear = {2020},\n\tnote = {Number: 1},\n\tkeywords = {Asthma},\n\tpages = {1901147},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-braithwaite-semprini-kearns-weatherall-pavord-optimalasthmacontroltimeforanewtarget-2020\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.atsjournals.org/doi/10.1164/rccm.201910-1934CI\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-braithwaite-semprini-kearns-weatherall-pavord-optimalasthmacontroltimeforanewtarget-2020', 'https://www.atsjournals.org/doi/10.1164/rccm.201910-1934CI', event);\">\n    Optimal Asthma Control: Time for a New Target.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Braithwaite, I.; Semprini, A.; Kearns, C.; Weatherall, M.;  and Pavord, I. D\n</span>\n\n  \n\n</span>\n\n  <i>American Journal of Respiratory and Critical Care Medicine</i>,rccm.201910–1934CI. January 2020.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.atsjournals.org/doi/10.1164/rccm.201910-1934CI\"\n     onclick=\"log_download('beasley-braithwaite-semprini-kearns-weatherall-pavord-optimalasthmacontroltimeforanewtarget-2020', 'https://www.atsjournals.org/doi/10.1164/rccm.201910-1934CI', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Optimal Asthma Control: Time for a New Target [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1164/rccm.201910-1934CI\"\n     onclick=\"log_download('beasley-braithwaite-semprini-kearns-weatherall-pavord-optimalasthmacontroltimeforanewtarget-2020', 'http://doi.org/10.1164/rccm.201910-1934CI', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-braithwaite-semprini-kearns-weatherall-pavord-optimalasthmacontroltimeforanewtarget-2020\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-braithwaite-semprini-kearns-weatherall-pavord-optimalasthmacontroltimeforanewtarget-2020')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_optimal_2020,\n\ttitle = {Optimal {Asthma} {Control}: {Time} for a {New} {Target}},\n\tissn = {1073-449X},\n\turl = {https://www.atsjournals.org/doi/10.1164/rccm.201910-1934CI},\n\tdoi = {10.1164/rccm.201910-1934CI},\n\tjournal = {American Journal of Respiratory and Critical Care Medicine},\n\tauthor = {Beasley, Richard and Braithwaite, Irene and Semprini, Alex and Kearns, Ciléin and Weatherall, Mark and Pavord, Ian D},\n\tmonth = jan,\n\tyear = {2020},\n\tkeywords = {Asthma},\n\tpages = {rccm.201910--1934CI},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2019\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2019')\"\n      onkeypress=\"toggleGroup('group_2019')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2019</span>\n      <span class=\"bibbase_group_count\">\n        \n        (10)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"semprini-shortt-ebmeier-semprini-varughese-holweg-matthews-fingleton-etal-changeinbiomarkersoftype2inflammationfollowingsevereexacerbationsofasthma-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'semprini-shortt-ebmeier-semprini-varughese-holweg-matthews-fingleton-etal-changeinbiomarkersoftype2inflammationfollowingsevereexacerbationsofasthma-2019', 'http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657', event);\">\n    Change in biomarkers of type-2 inflammation following severe exacerbations of asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Semprini, R.; Shortt, N.; Ebmeier, S.; Semprini, A.; Varughese, R.; Holweg, C. T J; Matthews, J. G; Fingleton, J.; Weatherall, M.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>;  and Braithwaite, I.\n</span>\n\n  \n\n</span>\n\n  <i>Thorax</i>, 74(1): 95–98. January 2019.\n  <span class=\"note\">Number: 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657\"\n     onclick=\"log_download('semprini-shortt-ebmeier-semprini-varughese-holweg-matthews-fingleton-etal-changeinbiomarkersoftype2inflammationfollowingsevereexacerbationsofasthma-2019', 'http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Change in biomarkers of type-2 inflammation following severe exacerbations of asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1136/thoraxjnl-2018-211657\"\n     onclick=\"log_download('semprini-shortt-ebmeier-semprini-varughese-holweg-matthews-fingleton-etal-changeinbiomarkersoftype2inflammationfollowingsevereexacerbationsofasthma-2019', 'http://doi.org/10.1136/thoraxjnl-2018-211657', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/semprini-shortt-ebmeier-semprini-varughese-holweg-matthews-fingleton-etal-changeinbiomarkersoftype2inflammationfollowingsevereexacerbationsofasthma-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('semprini-shortt-ebmeier-semprini-varughese-holweg-matthews-fingleton-etal-changeinbiomarkersoftype2inflammationfollowingsevereexacerbationsofasthma-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{semprini_change_2019,\n\ttitle = {Change in biomarkers of type-2 inflammation following severe exacerbations of asthma},\n\tvolume = {74},\n\tissn = {0040-6376, 1468-3296},\n\turl = {http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-211657},\n\tdoi = {10.1136/thoraxjnl-2018-211657},\n\tabstract = {We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33×10\n              9\n              /L, p{\\textless}0.001) while serum IgE levels were at their highest (339 vs 249 U/L, p{\\textless}0.001). Fractional exhaled Nitric Oxide levels were lowest 2 weeks after treatment (23 vs 33 ppb, p=0.06) and serum periostin levels were lowest 1 week after treatment (45·9 vs 50·9 ng/mL, p{\\textless}0.001). A delay of 4–8 weeks following a severe exacerbation is required if these biomarkers are used to guide the ongoing management of patients with asthma.\n            \n            \n              Trial registration number\n              Post-results; The Australia New Zealand Trial Registry, {\\textgreater}ACTRN12614000443695.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2020-08-23},\n\tjournal = {Thorax},\n\tauthor = {Semprini, Ruth and Shortt, Nick and Ebmeier, Stefan and Semprini, Alex and Varughese, Rachel and Holweg, Cecile T J and Matthews, John G and Fingleton, James and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},\n\tmonth = jan,\n\tyear = {2019},\n\tnote = {Number: 1},\n\tpages = {95--98},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  We investigated the time course of change of type-2 asthma biomarkers after a severe asthma exacerbation. Blood eosinophils were lowest immediately after treatment was initiated (0.07 vs 0.33×10 9 /L, p\\textless0.001) while serum IgE levels were at their highest (339 vs 249 U/L, p\\textless0.001). Fractional exhaled Nitric Oxide levels were lowest 2 weeks after treatment (23 vs 33 ppb, p=0.06) and serum periostin levels were lowest 1 week after treatment (45·9 vs 50·9 ng/mL, p\\textless0.001). A delay of 4–8 weeks following a severe exacerbation is required if these biomarkers are used to guide the ongoing management of patients with asthma. Trial registration number Post-results; The Australia New Zealand Trial Registry, \\textgreaterACTRN12614000443695.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"morales-strachan-asher-ellwood-pearce-garciamarcos-combinedimpactofhealthylifestylefactorsonriskofasthmarhinoconjunctivitisandeczemainschoolchildrenisaacphaseiii-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'morales-strachan-asher-ellwood-pearce-garciamarcos-combinedimpactofhealthylifestylefactorsonriskofasthmarhinoconjunctivitisandeczemainschoolchildrenisaacphaseiii-2019', 'http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668', event);\">\n    Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: ISAAC phase III.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Morales, E.; Strachan, D.; Asher, I.; Ellwood, P.; Pearce, N.;  and Garcia-Marcos, L.\n</span>\n\n  \n\n</span>\n\n  <i>Thorax</i>, 74(6): 531–538. June 2019.\n  <span class=\"note\">Number: 6</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668\"\n     onclick=\"log_download('morales-strachan-asher-ellwood-pearce-garciamarcos-combinedimpactofhealthylifestylefactorsonriskofasthmarhinoconjunctivitisandeczemainschoolchildrenisaacphaseiii-2019', 'http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: ISAAC phase III [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1136/thoraxjnl-2018-212668\"\n     onclick=\"log_download('morales-strachan-asher-ellwood-pearce-garciamarcos-combinedimpactofhealthylifestylefactorsonriskofasthmarhinoconjunctivitisandeczemainschoolchildrenisaacphaseiii-2019', 'http://doi.org/10.1136/thoraxjnl-2018-212668', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/morales-strachan-asher-ellwood-pearce-garciamarcos-combinedimpactofhealthylifestylefactorsonriskofasthmarhinoconjunctivitisandeczemainschoolchildrenisaacphaseiii-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('morales-strachan-asher-ellwood-pearce-garciamarcos-combinedimpactofhealthylifestylefactorsonriskofasthmarhinoconjunctivitisandeczemainschoolchildrenisaacphaseiii-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{morales_combined_2019,\n\ttitle = {Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children: {ISAAC} phase {III}},\n\tvolume = {74},\n\tissn = {0040-6376, 1468-3296},\n\tshorttitle = {Combined impact of healthy lifestyle factors on risk of asthma, rhinoconjunctivitis and eczema in school children},\n\turl = {http://thorax.bmj.com/lookup/doi/10.1136/thoraxjnl-2018-212668},\n\tdoi = {10.1136/thoraxjnl-2018-212668},\n\tabstract = {Background\n              Asthma is not the key focus of prevention strategies. A Healthy Lifestyle Index (HLI) was developed to examine the combined effect of modifiable lifestyle factors on asthma, rhinoconjunctivitis and eczema using data from the International Study of Asthma and Allergies in Childhood (ISAAC) phase III.\n            \n            \n              Methods\n              Information on symptoms of asthma, rhinoconjunctivitis, eczema and several lifestyle factors was obtained from children aged 6–7 years through written questionnaires. The HLI combined five lifestyle factors: no parental smoking, child’s adherence to Mediterranean diet, child’s healthy body mass index, high physical activity and non-sedentary behaviour. The association between the HLI and risk of asthma, rhinoconjunctivitis and eczema was evaluated using multilevel mixed-effects logistic regression models.\n            \n            \n              Findings\n              Data of 70 795 children from 37 centres in 19 countries were analysed. Each additional healthy lifestyle factor was associated with a reduced risk of current wheeze (OR 0.87, 95\\% CI 0.84 to 0.89), asthma ever (OR 0.89, 95\\% CI 0.87 to 0.92), current symptoms of rhinoconjunctivitis (OR 0.95, 95\\% CI 0.92 to 0.97) and current symptoms of eczema (OR 0.92, 95\\% CI 0.92 to 0.98). Theoretically, if associations were causal, a combination of four or five healthy lifestyle factors would result into a reduction up to 16\\% of asthma cases (ranging from 2.7\\% to 26.3 \\% according to region of the world).\n            \n            \n              Conclusions\n              These findings should be interpreted with caution given the limitations to infer causality from cross-sectional observational data. Efficacy of interventions to improve multiple modifiable lifestyle factors to reduce the burden asthma and allergy in childhood should be assessed.},\n\tlanguage = {en},\n\tnumber = {6},\n\turldate = {2020-08-23},\n\tjournal = {Thorax},\n\tauthor = {Morales, Eva and Strachan, David and Asher, Innes and Ellwood, Philippa and Pearce, Neil and Garcia-Marcos, Luis},\n\tmonth = jun,\n\tyear = {2019},\n\tnote = {Number: 6},\n\tpages = {531--538},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Background Asthma is not the key focus of prevention strategies. A Healthy Lifestyle Index (HLI) was developed to examine the combined effect of modifiable lifestyle factors on asthma, rhinoconjunctivitis and eczema using data from the International Study of Asthma and Allergies in Childhood (ISAAC) phase III. Methods Information on symptoms of asthma, rhinoconjunctivitis, eczema and several lifestyle factors was obtained from children aged 6–7 years through written questionnaires. The HLI combined five lifestyle factors: no parental smoking, child’s adherence to Mediterranean diet, child’s healthy body mass index, high physical activity and non-sedentary behaviour. The association between the HLI and risk of asthma, rhinoconjunctivitis and eczema was evaluated using multilevel mixed-effects logistic regression models. Findings Data of 70 795 children from 37 centres in 19 countries were analysed. Each additional healthy lifestyle factor was associated with a reduced risk of current wheeze (OR 0.87, 95% CI 0.84 to 0.89), asthma ever (OR 0.89, 95% CI 0.87 to 0.92), current symptoms of rhinoconjunctivitis (OR 0.95, 95% CI 0.92 to 0.97) and current symptoms of eczema (OR 0.92, 95% CI 0.92 to 0.98). Theoretically, if associations were causal, a combination of four or five healthy lifestyle factors would result into a reduction up to 16% of asthma cases (ranging from 2.7% to 26.3 % according to region of the world). Conclusions These findings should be interpreted with caution given the limitations to infer causality from cross-sectional observational data. Efficacy of interventions to improve multiple modifiable lifestyle factors to reduce the burden asthma and allergy in childhood should be assessed.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"hardy-baggott-fingleton-reddel-hancox-harwood-corin-sparks-etal-budesonideformoterolrelievertherapyversusmaintenancebudesonideplusterbutalinerelievertherapyinadultswithmildtomoderateasthmapracticala52weekopenlabelmulticentresuperiorityrandomisedcontrolledtrial-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'hardy-baggott-fingleton-reddel-hancox-harwood-corin-sparks-etal-budesonideformoterolrelievertherapyversusmaintenancebudesonideplusterbutalinerelievertherapyinadultswithmildtomoderateasthmapracticala52weekopenlabelmulticentresuperiorityrandomisedcontrolledtrial-2019', 'https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488', event);\">\n    Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Hardy, J.; Baggott, C.; Fingleton, J.; Reddel, H. K; Hancox, R. J; Harwood, M.; Corin, A.; Sparks, J.; Hall, D.; Sabbagh, D.; Mane, S.; Vohlidkova, A.; Martindale, J.; Williams, M.; Shirtcliffe, P.; Holliday, M.; Weatherall, M.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Corin, A.; Dronfield, L.; Helm, C.; Paterson, T.; Poudel, B.; Dyer, M.; Jasinski, C.; Sheahan, D.; Sheahan, P.; Gailer, N.; Van Zuilen, J.; Basa, A.; Devereaux, C.; Egan, K.; Haughey, S.; Marks, R.; Venter, D.; Zhang, H.; Trevithick, K.; Williams, M.; Williams, P.; Baggott, C.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Braithwaite, I.; Eathorne, A.; Ebmeier, S.; Fingleton, J.; Hall, D.; Hardy, J.; Harwood, M.; Holliday, M.; Houghton, C.; Mane, S.; Martindale, J.; Oldfield, K.; Pilcher, J.; Sabbagh, D.; Shirtcliffe, P.; Snively, S.; Sparks, J.; Vohlidkova, A.; Williams, M.; Collins, P.; Hassan, S.; Lam, A.; Lionnet, C.; Montgomery, B.; Smaill, L.; Moon, S.; Quinn, D.; Bayly-McCredie, E.; Millar-Coote, C.; Millar-Coote, D.; Reid, J.; Samuel, A.; Burton, N.; Mullard, T.; Tranquilino, T.; Watson, E.; Bell, J.; Harris, R.; Richmond, J.; Smith, S.; Krivan, B.; Robertson, C.; Hancox, R. J; Weatherall, M.; Glensor, S.; O'Connor, D.; Porrachia, A.;  and Reddel, H. K\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet</i>, 394(10202): 919–928. September 2019.\n  <span class=\"note\">Number: 10202</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488\"\n     onclick=\"log_download('hardy-baggott-fingleton-reddel-hancox-harwood-corin-sparks-etal-budesonideformoterolrelievertherapyversusmaintenancebudesonideplusterbutalinerelievertherapyinadultswithmildtomoderateasthmapracticala52weekopenlabelmulticentresuperiorityrandomisedcontrolledtrial-2019', 'https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S0140-6736(19)31948-8\"\n     onclick=\"log_download('hardy-baggott-fingleton-reddel-hancox-harwood-corin-sparks-etal-budesonideformoterolrelievertherapyversusmaintenancebudesonideplusterbutalinerelievertherapyinadultswithmildtomoderateasthmapracticala52weekopenlabelmulticentresuperiorityrandomisedcontrolledtrial-2019', 'http://doi.org/10.1016/S0140-6736(19)31948-8', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/hardy-baggott-fingleton-reddel-hancox-harwood-corin-sparks-etal-budesonideformoterolrelievertherapyversusmaintenancebudesonideplusterbutalinerelievertherapyinadultswithmildtomoderateasthmapracticala52weekopenlabelmulticentresuperiorityrandomisedcontrolledtrial-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('hardy-baggott-fingleton-reddel-hancox-harwood-corin-sparks-etal-budesonideformoterolrelievertherapyversusmaintenancebudesonideplusterbutalinerelievertherapyinadultswithmildtomoderateasthmapracticala52weekopenlabelmulticentresuperiorityrandomisedcontrolledtrial-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{hardy_budesonide-formoterol_2019,\n\ttitle = {Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma ({PRACTICAL}): a 52-week, open-label, multicentre, superiority, randomised controlled trial},\n\tvolume = {394},\n\tissn = {01406736},\n\tshorttitle = {Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma ({PRACTICAL})},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0140673619319488},\n\tdoi = {10.1016/S0140-6736(19)31948-8},\n\tlanguage = {en},\n\tnumber = {10202},\n\turldate = {2020-08-23},\n\tjournal = {The Lancet},\n\tauthor = {Hardy, Jo and Baggott, Christina and Fingleton, James and Reddel, Helen K and Hancox, Robert J and Harwood, Matire and Corin, Andrew and Sparks, Jenny and Hall, Daniela and Sabbagh, Doñah and Mane, Saras and Vohlidkova, Alexandra and Martindale, John and Williams, Mathew and Shirtcliffe, Philippa and Holliday, Mark and Weatherall, Mark and Beasley, Richard and Corin, Andrew and Dronfield, Liz and Helm, Colin and Paterson, Tracy and Poudel, Bhuwan and Dyer, Malcolm and Jasinski, Christine and Sheahan, Davitt and Sheahan, Pamela and Gailer, Nick and Van Zuilen, Jan and Basa, Andy and Devereaux, Christine and Egan, Karin and Haughey, Sneha and Marks, Rodney and Venter, Dirk and Zhang, Hank and Trevithick, Karen and Williams, Mike and Williams, Philippa and Baggott, Christina and Beasley, Richard and Braithwaite, Irene and Eathorne, Alexandra and Ebmeier, Stefan and Fingleton, James and Hall, Daniela and Hardy, Jo and Harwood, Matire and Holliday, Mark and Houghton, Claire and Mane, Saras and Martindale, John and Oldfield, Karen and Pilcher, Janine and Sabbagh, Doñah and Shirtcliffe, Philippa and Snively, Suzanne and Sparks, Jenny and Vohlidkova, Alexandra and Williams, Mathew and Collins, Patrick and Hassan, Summer and Lam, Annika and Lionnet, Claudette and Montgomery, Barney and Smaill, Liz and Moon, Stella and Quinn, Dean and Bayly-McCredie, Elena and Millar-Coote, Chris and Millar-Coote, Dean and Reid, Jim and Samuel, Anna and Burton, Nicola and Mullard, Tina and Tranquilino, Tyronne and Watson, Edward and Bell, Jill and Harris, Rachel and Richmond, John and Smith, Sue and Krivan, Brent and Robertson, Cheryl and Hancox, Robert J and Weatherall, Mark and Glensor, Sue and O&#x27;Connor, Dermot and Porrachia, Anne-Christine and Reddel, Helen K},\n\tmonth = sep,\n\tyear = {2019},\n\tnote = {Number: 10202},\n\tpages = {919--928},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"denton-horelacy-radhakrishna-gilbert-tay-lee-dabscheck-harvey-etal-severeasthmaglobalevaluationsageanelectronicplatformforsevereasthma-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'denton-horelacy-radhakrishna-gilbert-tay-lee-dabscheck-harvey-etal-severeasthmaglobalevaluationsageanelectronicplatformforsevereasthma-2019', 'https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X', event);\">\n    Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Denton, E.; Hore-Lacy, F.; Radhakrishna, N.; Gilbert, A.; Tay, T.; Lee, J.; Dabscheck, E.; Harvey, E. S.; Bulathsinhala, L.; Fingleton, J.; Price, D.; Gibson, P. G.; O'Hehir, R.;  and Hew, M.\n</span>\n\n  \n\n</span>\n\n  <i>The Journal of Allergy and Clinical Immunology: In Practice</i>, 7(5): 1440–1449. May 2019.\n  <span class=\"note\">Number: 5</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X\"\n     onclick=\"log_download('denton-horelacy-radhakrishna-gilbert-tay-lee-dabscheck-harvey-etal-severeasthmaglobalevaluationsageanelectronicplatformforsevereasthma-2019', 'https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaip.2019.02.042\"\n     onclick=\"log_download('denton-horelacy-radhakrishna-gilbert-tay-lee-dabscheck-harvey-etal-severeasthmaglobalevaluationsageanelectronicplatformforsevereasthma-2019', 'http://doi.org/10.1016/j.jaip.2019.02.042', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/denton-horelacy-radhakrishna-gilbert-tay-lee-dabscheck-harvey-etal-severeasthmaglobalevaluationsageanelectronicplatformforsevereasthma-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('denton-horelacy-radhakrishna-gilbert-tay-lee-dabscheck-harvey-etal-severeasthmaglobalevaluationsageanelectronicplatformforsevereasthma-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{denton_severe_2019,\n\ttitle = {Severe {Asthma} {Global} {Evaluation} ({SAGE}): {An} {Electronic} {Platform} for {Severe} {Asthma}},\n\tvolume = {7},\n\tissn = {22132198},\n\tshorttitle = {Severe {Asthma} {Global} {Evaluation} ({SAGE})},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S221321981930265X},\n\tdoi = {10.1016/j.jaip.2019.02.042},\n\tlanguage = {en},\n\tnumber = {5},\n\turldate = {2020-08-23},\n\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\n\tauthor = {Denton, Eve and Hore-Lacy, Fiona and Radhakrishna, Naghmeh and Gilbert, Annie and Tay, TunnRen and Lee, Joy and Dabscheck, Eli and Harvey, Erin S. and Bulathsinhala, Lakmini and Fingleton, James and Price, David and Gibson, Peter G. and O&#x27;Hehir, Robyn and Hew, Mark},\n\tmonth = may,\n\tyear = {2019},\n\tnote = {Number: 5},\n\tpages = {1440--1449},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-harper-bird-dunphy-semprini-pavord-papi-weatherall-doseresponserelationshipoficsfastonsetlabaasrelievertherapyinasthma-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-harper-bird-dunphy-semprini-pavord-papi-weatherall-doseresponserelationshipoficsfastonsetlabaasrelievertherapyinasthma-2019', 'https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4', event);\">\n    Dose-response relationship of ICS/fast-onset LABA as reliever therapy in asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Harper, J.; Bird, G.; Dunphy, H.; Semprini, A.; Pavord, I. D.; Papi, A.;  and Weatherall, M.\n</span>\n\n  \n\n</span>\n\n  <i>BMC Pulmonary Medicine</i>, 19(1): 264. December 2019.\n  <span class=\"note\">Number: 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4\"\n     onclick=\"log_download('beasley-harper-bird-dunphy-semprini-pavord-papi-weatherall-doseresponserelationshipoficsfastonsetlabaasrelievertherapyinasthma-2019', 'https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Dose-response relationship of ICS/fast-onset LABA as reliever therapy in asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1186/s12890-019-1014-4\"\n     onclick=\"log_download('beasley-harper-bird-dunphy-semprini-pavord-papi-weatherall-doseresponserelationshipoficsfastonsetlabaasrelievertherapyinasthma-2019', 'http://doi.org/10.1186/s12890-019-1014-4', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-harper-bird-dunphy-semprini-pavord-papi-weatherall-doseresponserelationshipoficsfastonsetlabaasrelievertherapyinasthma-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-harper-bird-dunphy-semprini-pavord-papi-weatherall-doseresponserelationshipoficsfastonsetlabaasrelievertherapyinasthma-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_dose-response_2019,\n\ttitle = {Dose-response relationship of {ICS}/fast-onset {LABA} as reliever therapy in asthma},\n\tvolume = {19},\n\tissn = {1471-2466},\n\turl = {https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-019-1014-4},\n\tdoi = {10.1186/s12890-019-1014-4},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2020-08-23},\n\tjournal = {BMC Pulmonary Medicine},\n\tauthor = {Beasley, Richard and Harper, James and Bird, Grace and Dunphy, Harriette and Semprini, Alex and Pavord, Ian D. and Papi, Alberto and Weatherall, Mark},\n\tmonth = dec,\n\tyear = {2019},\n\tnote = {Number: 1},\n\tpages = {264},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-controlledtrialofbudesonideformoterolasneededformildasthma-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://www.nejm.org/doi/10.1056/NEJMoa1901963\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-controlledtrialofbudesonideformoterolasneededformildasthma-2019', 'http://www.nejm.org/doi/10.1056/NEJMoa1901963', event);\">\n    Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Holliday, M.; Reddel, H. K.; Braithwaite, I.; Ebmeier, S.; Hancox, R. J.; Harrison, T.; Houghton, C.; Oldfield, K.; Papi, A.; Pavord, I. D.; Williams, M.;  and Weatherall, M.\n</span>\n\n  \n\n</span>\n\n  <i>New England Journal of Medicine</i>, 380(21): 2020–2030. May 2019.\n  <span class=\"note\">Number: 21</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://www.nejm.org/doi/10.1056/NEJMoa1901963\"\n     onclick=\"log_download('beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-controlledtrialofbudesonideformoterolasneededformildasthma-2019', 'http://www.nejm.org/doi/10.1056/NEJMoa1901963', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1056/NEJMoa1901963\"\n     onclick=\"log_download('beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-controlledtrialofbudesonideformoterolasneededformildasthma-2019', 'http://doi.org/10.1056/NEJMoa1901963', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-controlledtrialofbudesonideformoterolasneededformildasthma-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-controlledtrialofbudesonideformoterolasneededformildasthma-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_controlled_2019,\n\ttitle = {Controlled {Trial} of {Budesonide}–{Formoterol} as {Needed} for {Mild} {Asthma}},\n\tvolume = {380},\n\tissn = {0028-4793, 1533-4406},\n\turl = {http://www.nejm.org/doi/10.1056/NEJMoa1901963},\n\tdoi = {10.1056/NEJMoa1901963},\n\tlanguage = {en},\n\tnumber = {21},\n\turldate = {2020-08-23},\n\tjournal = {New England Journal of Medicine},\n\tauthor = {Beasley, Richard and Holliday, Mark and Reddel, Helen K. and Braithwaite, Irene and Ebmeier, Stefan and Hancox, Robert J. and Harrison, Tim and Houghton, Claire and Oldfield, Karen and Papi, Alberto and Pavord, Ian D. and Williams, Mathew and Weatherall, Mark},\n\tmonth = may,\n\tyear = {2019},\n\tnote = {Number: 21},\n\tpages = {2020--2030},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-pragmaticrandomizedcontrolledtrialofbudesonideformoterolrelievertherapyinadultswithmildasthma-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Pragmatic Randomized Controlled Trial of Budesonide/Formoterol Reliever Therapy in Adults with Mild Asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R W; Holliday, M; Reddel, H K; Braithwaite, I; Ebmeier, S; Hancox, R; Harrison, T; Houghton, C; Oldfield, K;  and Papi, A\n</span>\n\n  \n\n</span>\n\n  In <i>D101. CLINICAL AND TRANSLATIONAL STUDIES IN ASTHMA AND COPD</i>, pages A7477–A7477. American Thoracic Society,  2019.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-pragmaticrandomizedcontrolledtrialofbudesonideformoterolrelievertherapyinadultswithmildasthma-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-holliday-reddel-braithwaite-ebmeier-hancox-harrison-houghton-etal-pragmaticrandomizedcontrolledtrialofbudesonideformoterolrelievertherapyinadultswithmildasthma-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@incollection{beasley_pragmatic_2019,\n\ttitle = {Pragmatic {Randomized} {Controlled} {Trial} of {Budesonide}/{Formoterol} {Reliever} {Therapy} in {Adults} with {Mild} {Asthma}},\n\tisbn = {1073-449X},\n\tbooktitle = {D101. {CLINICAL} {AND} {TRANSLATIONAL} {STUDIES} {IN} {ASTHMA} {AND} {COPD}},\n\tpublisher = {American Thoracic Society},\n\tauthor = {Beasley, R W and Holliday, M and Reddel, H K and Braithwaite, I and Ebmeier, S and Hancox, R and Harrison, T and Houghton, C and Oldfield, K and Papi, A},\n\tyear = {2019},\n\tpages = {A7477--A7477},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"baggott-beasley-triagingtreatabletraitsinasthma-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Triaging treatable traits in asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Baggott, C.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Respirology</i>, 24(1): 5–6.  2019.\n  <span class=\"note\">Number: 1 Publisher: Wiley Online Library</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/baggott-beasley-triagingtreatabletraitsinasthma-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('baggott-beasley-triagingtreatabletraitsinasthma-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{baggott_triaging_2019,\n\ttitle = {Triaging treatable traits in asthma},\n\tvolume = {24},\n\tissn = {1323-7799},\n\tnumber = {1},\n\tjournal = {Respirology},\n\tauthor = {Baggott, Christina and Beasley, Richard},\n\tyear = {2019},\n\tnote = {Number: 1\nPublisher: Wiley Online Library},\n\tpages = {5--6},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-bird-harper-weatherall-asthmaparadoxestimeforanewapproachacrossthespectrumofasthmaseverity-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Asthma paradoxes: time for a new approach across the spectrum of asthma severity.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Bird, G.; Harper, J.;  and Weatherall, M.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 53: 1900218.  2019.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.00218-2019\"\n     onclick=\"log_download('beasley-bird-harper-weatherall-asthmaparadoxestimeforanewapproachacrossthespectrumofasthmaseverity-2019', 'http://doi.org/10.1183/13993003.00218-2019', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-bird-harper-weatherall-asthmaparadoxestimeforanewapproachacrossthespectrumofasthmaseverity-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-bird-harper-weatherall-asthmaparadoxestimeforanewapproachacrossthespectrumofasthmaseverity-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_asthma_2019,\n\ttitle = {Asthma paradoxes: time for a new approach across the spectrum of asthma severity},\n\tvolume = {53},\n\tdoi = {10.1183/13993003.00218-2019},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Beasley, Richard and Bird, Grace and Harper, James and Weatherall, Mark},\n\tyear = {2019},\n\tpages = {1900218},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-harper-bird-maijers-weatherall-dpavord-inhaledcorticosteroidtherapyinadultasthmatimeforanewtherapeuticdoseterminology-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Inhaled Corticosteroid Therapy in Adult Asthma: Time for a New Therapeutic Dose Terminology.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Harper, J.; Bird, G.; Maijers, I.; Weatherall, M.;  and D Pavord, I.\n</span>\n\n  \n\n</span>\n\n  <i>American Journal of Respiratory and Critical Care Medicine</i>.  2019.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1164/rccm.201810-1868CI\"\n     onclick=\"log_download('beasley-harper-bird-maijers-weatherall-dpavord-inhaledcorticosteroidtherapyinadultasthmatimeforanewtherapeuticdoseterminology-2019', 'http://doi.org/10.1164/rccm.201810-1868CI', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-harper-bird-maijers-weatherall-dpavord-inhaledcorticosteroidtherapyinadultasthmatimeforanewtherapeuticdoseterminology-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-harper-bird-maijers-weatherall-dpavord-inhaledcorticosteroidtherapyinadultasthmatimeforanewtherapeuticdoseterminology-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_inhaled_2019,\n\ttitle = {Inhaled {Corticosteroid} {Therapy} in {Adult} {Asthma}: {Time} for a {New} {Therapeutic} {Dose} {Terminology}},\n\tdoi = {10.1164/rccm.201810-1868CI},\n\tjournal = {American Journal of Respiratory and Critical Care Medicine},\n\tauthor = {Beasley, Richard and Harper, James and Bird, Grace and Maijers, Ingrid and Weatherall, Mark and D Pavord, Ian},\n\tyear = {2019},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2018\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2018')\"\n      onkeypress=\"toggleGroup('group_2018')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2018</span>\n      <span class=\"bibbase_group_count\">\n        \n        (5)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"semprini-williams-semprini-mcdouall-fingleton-holweg-weatherall-beasley-etal-type2biomarkersandpredictionoffutureexacerbationsandlungfunctiondeclineinadultasthma-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Type 2 Biomarkers and Prediction of Future Exacerbations and Lung Function Decline in Adult Asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Semprini, R.; Williams, M.; Semprini, A.; McDouall, A.; Fingleton, J.; Holweg, C.; Weatherall, M.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>;  and Braithwaite, I.\n</span>\n\n  \n\n</span>\n\n  <i>The Journal of Allergy and Clinical Immunology: In Practice</i>, 6.  2018.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaip.2018.03.004\"\n     onclick=\"log_download('semprini-williams-semprini-mcdouall-fingleton-holweg-weatherall-beasley-etal-type2biomarkersandpredictionoffutureexacerbationsandlungfunctiondeclineinadultasthma-2018', 'http://doi.org/10.1016/j.jaip.2018.03.004', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/semprini-williams-semprini-mcdouall-fingleton-holweg-weatherall-beasley-etal-type2biomarkersandpredictionoffutureexacerbationsandlungfunctiondeclineinadultasthma-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('semprini-williams-semprini-mcdouall-fingleton-holweg-weatherall-beasley-etal-type2biomarkersandpredictionoffutureexacerbationsandlungfunctiondeclineinadultasthma-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{semprini_type_2018,\n\ttitle = {Type 2 {Biomarkers} and {Prediction} of {Future} {Exacerbations} and {Lung} {Function} {Decline} in {Adult} {Asthma}},\n\tvolume = {6},\n\tdoi = {10.1016/j.jaip.2018.03.004},\n\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\n\tauthor = {Semprini, Ruth and Williams, Mathew and Semprini, Alex and McDouall, Alice and Fingleton, James and Holweg, Cécile and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},\n\tyear = {2018},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-bird-harper-weatherall-thefurtherparadoxesofasthmamanagementtimeforanewapproachacrossthespectrumofasthmaseverity-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  The further paradoxes of asthma management: Time for a new approach across the spectrum of asthma severity.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Bird, G.; Harper, J.;  and Weatherall, M.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 52: 1800694.  2018.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.00694-2018\"\n     onclick=\"log_download('beasley-bird-harper-weatherall-thefurtherparadoxesofasthmamanagementtimeforanewapproachacrossthespectrumofasthmaseverity-2018', 'http://doi.org/10.1183/13993003.00694-2018', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-bird-harper-weatherall-thefurtherparadoxesofasthmamanagementtimeforanewapproachacrossthespectrumofasthmaseverity-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-bird-harper-weatherall-thefurtherparadoxesofasthmamanagementtimeforanewapproachacrossthespectrumofasthmaseverity-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_further_2018,\n\ttitle = {The further paradoxes of asthma management: {Time} for a new approach across the spectrum of asthma severity},\n\tvolume = {52},\n\tdoi = {10.1183/13993003.00694-2018},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Beasley, Richard and Bird, Grace and Harper, James and Weatherall, Mark},\n\tyear = {2018},\n\tpages = {1800694},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"braithwaite-semprini-beasley-theclinicalrelevanceofperiostininasthma-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  The Clinical Relevance of Periostin in Asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Braithwaite, I.; Semprini, R.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Barcelona Respiratory Network</i>, 4.  2018.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.23866/BRNRev:2017-0028\"\n     onclick=\"log_download('braithwaite-semprini-beasley-theclinicalrelevanceofperiostininasthma-2018', 'http://doi.org/10.23866/BRNRev:2017-0028', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/braithwaite-semprini-beasley-theclinicalrelevanceofperiostininasthma-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('braithwaite-semprini-beasley-theclinicalrelevanceofperiostininasthma-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{braithwaite_clinical_2018,\n\ttitle = {The {Clinical} {Relevance} of {Periostin} in {Asthma}},\n\tvolume = {4},\n\tdoi = {10.23866/BRNRev:2017-0028},\n\tjournal = {Barcelona Respiratory Network},\n\tauthor = {Braithwaite, Irene and Semprini, Ruth and Beasley, Richard},\n\tyear = {2018},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"varughese-semprini-munro-fingleton-holweg-weatherall-beasley-braithwaite-serumperiostinlevelsfollowingsmallbonefractureslongbonefracturesandjointreplacementsanobservationalstudy-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Serum periostin levels following small bone fractures, long bone fractures and joint replacements: An observational study.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Varughese, R.; Semprini, R.; Munro, C.; Fingleton, J.; Holweg, C.; Weatherall, M.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>;  and Braithwaite, I.\n</span>\n\n  \n\n</span>\n\n  <i>Allergy, Asthma & Clinical Immunology</i>, 14.  2018.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1186/s13223-018-0254-9\"\n     onclick=\"log_download('varughese-semprini-munro-fingleton-holweg-weatherall-beasley-braithwaite-serumperiostinlevelsfollowingsmallbonefractureslongbonefracturesandjointreplacementsanobservationalstudy-2018', 'http://doi.org/10.1186/s13223-018-0254-9', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/varughese-semprini-munro-fingleton-holweg-weatherall-beasley-braithwaite-serumperiostinlevelsfollowingsmallbonefractureslongbonefracturesandjointreplacementsanobservationalstudy-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('varughese-semprini-munro-fingleton-holweg-weatherall-beasley-braithwaite-serumperiostinlevelsfollowingsmallbonefractureslongbonefracturesandjointreplacementsanobservationalstudy-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{varughese_serum_2018,\n\ttitle = {Serum periostin levels following small bone fractures, long bone fractures and joint replacements: {An} observational study},\n\tvolume = {14},\n\tdoi = {10.1186/s13223-018-0254-9},\n\tjournal = {Allergy, Asthma \\&amp; Clinical Immunology},\n\tauthor = {Varughese, Rachel and Semprini, Ruth and Munro, Claire and Fingleton, James and Holweg, Cecile and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},\n\tyear = {2018},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"tan-varughese-semprini-montgomery-holweg-olsson-caswellsmith-fingleton-etal-serumperiostinlevelsinadultsofchinesedescentanobservationalstudy-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Serum periostin levels in adults of Chinese descent: an observational study.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Tan, E.; Varughese, R.; Semprini, R.; Montgomery, B.; Holweg, C.; Olsson, J.; Caswell-Smith, R.; Fingleton, J.; Weatherall, M.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>;  and Braithwaite, I.\n</span>\n\n  \n\n</span>\n\n  <i>Allergy, Asthma & Clinical Immunology</i>, 14.  2018.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1186/s13223-018-0312-3\"\n     onclick=\"log_download('tan-varughese-semprini-montgomery-holweg-olsson-caswellsmith-fingleton-etal-serumperiostinlevelsinadultsofchinesedescentanobservationalstudy-2018', 'http://doi.org/10.1186/s13223-018-0312-3', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/tan-varughese-semprini-montgomery-holweg-olsson-caswellsmith-fingleton-etal-serumperiostinlevelsinadultsofchinesedescentanobservationalstudy-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('tan-varughese-semprini-montgomery-holweg-olsson-caswellsmith-fingleton-etal-serumperiostinlevelsinadultsofchinesedescentanobservationalstudy-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{tan_serum_2018,\n\ttitle = {Serum periostin levels in adults of {Chinese} descent: an observational study},\n\tvolume = {14},\n\tdoi = {10.1186/s13223-018-0312-3},\n\tjournal = {Allergy, Asthma \\&amp; Clinical Immunology},\n\tauthor = {Tan, Evan and Varughese, Rachel and Semprini, Ruth and Montgomery, Barney and Holweg, Cecile and Olsson, Julie and Caswell-Smith, Rachel and Fingleton, James and Weatherall, Mark and Beasley, Richard and Braithwaite, Irene},\n\tyear = {2018},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2017\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2017')\"\n      onkeypress=\"toggleGroup('group_2017')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2017</span>\n      <span class=\"bibbase_group_count\">\n        \n        (4)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"beasley-weatherall-vitamindandasthmaacasetoanswer-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Vitamin D and asthma: a case to answer.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>;  and Weatherall, M.\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet Respiratory Medicine</i>, 5(11): 839–840.  2017.\n  <span class=\"note\">Number: 11 Publisher: Elsevier</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-weatherall-vitamindandasthmaacasetoanswer-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-weatherall-vitamindandasthmaacasetoanswer-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_vitamin_2017,\n\ttitle = {Vitamin {D} and asthma: a case to answer},\n\tvolume = {5},\n\tissn = {2213-2600},\n\tnumber = {11},\n\tjournal = {The Lancet Respiratory Medicine},\n\tauthor = {Beasley, Richard and Weatherall, Mark},\n\tyear = {2017},\n\tnote = {Number: 11\nPublisher: Elsevier},\n\tpages = {839--840},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"ebmeier-thayabaran-braithwaite-bnamara-weatherall-beasley-trendsininternationalasthmamortalityanalysisofdatafromthewhomortalitydatabasefrom46countries19932012-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Trends in international asthma mortality: Analysis of data from the WHO Mortality Database from 46 countries (1993-2012).\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Ebmeier, S.; Thayabaran, D.; Braithwaite, I.; Bénamara, C.; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>The Lancet</i>, 390.  2017.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S0140-6736(17)31448-4\"\n     onclick=\"log_download('ebmeier-thayabaran-braithwaite-bnamara-weatherall-beasley-trendsininternationalasthmamortalityanalysisofdatafromthewhomortalitydatabasefrom46countries19932012-2017', 'http://doi.org/10.1016/S0140-6736(17)31448-4', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/ebmeier-thayabaran-braithwaite-bnamara-weatherall-beasley-trendsininternationalasthmamortalityanalysisofdatafromthewhomortalitydatabasefrom46countries19932012-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('ebmeier-thayabaran-braithwaite-bnamara-weatherall-beasley-trendsininternationalasthmamortalityanalysisofdatafromthewhomortalitydatabasefrom46countries19932012-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{ebmeier_trends_2017,\n\ttitle = {Trends in international asthma mortality: {Analysis} of data from the {WHO} {Mortality} {Database} from 46 countries (1993-2012)},\n\tvolume = {390},\n\tdoi = {10.1016/S0140-6736(17)31448-4},\n\tjournal = {The Lancet},\n\tauthor = {Ebmeier, Stefan and Thayabaran, Darmiga and Braithwaite, Irene and Bénamara, Clément and Weatherall, Mark and Beasley, Richard},\n\tyear = {2017},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"power-williams-semprini-munro-caswellsmith-pilcher-holliday-fingleton-etal-rctoftheeffectofberryfruitpolyphenoliccultivarextractinmildsteroidnaiveasthmaacrossoverplacebocontrolledstudy-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  RCT of the effect of berryfruit polyphenolic cultivar extract in mild steroid-naive asthma: a cross-over, placebo-controlled study.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Power, S.; Williams, M.; Semprini, A.; Munro, C.; Caswell-Smith, R.; Pilcher, J.; Holliday, M.; Fingleton, J.; Harper, J.;  and Hurst, R.\n</span>\n\n  \n\n</span>\n\n  <i>BMJ open</i>, 7(3): e013850.  2017.\n  <span class=\"note\">Number: 3 Publisher: British Medical Journal Publishing Group</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/power-williams-semprini-munro-caswellsmith-pilcher-holliday-fingleton-etal-rctoftheeffectofberryfruitpolyphenoliccultivarextractinmildsteroidnaiveasthmaacrossoverplacebocontrolledstudy-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('power-williams-semprini-munro-caswellsmith-pilcher-holliday-fingleton-etal-rctoftheeffectofberryfruitpolyphenoliccultivarextractinmildsteroidnaiveasthmaacrossoverplacebocontrolledstudy-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{power_rct_2017,\n\ttitle = {{RCT} of the effect of berryfruit polyphenolic cultivar extract in mild steroid-naive asthma: a cross-over, placebo-controlled study},\n\tvolume = {7},\n\tissn = {2044-6055},\n\tnumber = {3},\n\tjournal = {BMJ open},\n\tauthor = {Power, Sharon and Williams, Mathew and Semprini, Alex and Munro, Claire and Caswell-Smith, Rachel and Pilcher, Janine and Holliday, Mark and Fingleton, James and Harper, Jacquie and Hurst, Roger},\n\tyear = {2017},\n\tnote = {Number: 3\nPublisher: British Medical Journal Publishing Group},\n\tpages = {e013850},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-hancox-newzealandasthmaguidelinesupdated-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  New Zealand asthma guidelines updated.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.;  and Hancox, R. J\n</span>\n\n  \n\n</span>\n\n  <i>The New Zealand Medical Journal (Online)</i>, 130(1466): 7–9.  2017.\n  <span class=\"note\">Number: 1466 Publisher: New Zealand Medical Association (NZMA)</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-hancox-newzealandasthmaguidelinesupdated-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-hancox-newzealandasthmaguidelinesupdated-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_new_2017,\n\ttitle = {New {Zealand} asthma guidelines updated},\n\tvolume = {130},\n\tissn = {1175-8716},\n\tnumber = {1466},\n\tjournal = {The New Zealand Medical Journal (Online)},\n\tauthor = {Beasley, Richard and Hancox, Robert J},\n\tyear = {2017},\n\tnote = {Number: 1466\nPublisher: New Zealand Medical Association (NZMA)},\n\tpages = {7--9},\n}\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2016\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2016')\"\n      onkeypress=\"toggleGroup('group_2016')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2016</span>\n      <span class=\"bibbase_group_count\">\n        \n        (4)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"pilcher-holliday-ebmeier-mckinstry-messaoudi-weatherall-beasley-validationofametereddoseinhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Validation of a metered dose inhaler electronic monitoring device: Implications for asthma clinical trial use.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Pilcher, J.; Holliday, M.; Ebmeier, S.; McKinstry, S.; Messaoudi, F.; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>BMJ Open Respiratory Research</i>, 3: e000128.  2016.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1136/bmjresp-2016-000128\"\n     onclick=\"log_download('pilcher-holliday-ebmeier-mckinstry-messaoudi-weatherall-beasley-validationofametereddoseinhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2016', 'http://doi.org/10.1136/bmjresp-2016-000128', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/pilcher-holliday-ebmeier-mckinstry-messaoudi-weatherall-beasley-validationofametereddoseinhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('pilcher-holliday-ebmeier-mckinstry-messaoudi-weatherall-beasley-validationofametereddoseinhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{pilcher_validation_2016,\n\ttitle = {Validation of a metered dose inhaler electronic monitoring device: {Implications} for asthma clinical trial use},\n\tvolume = {3},\n\tdoi = {10.1136/bmjresp-2016-000128},\n\tjournal = {BMJ Open Respiratory Research},\n\tauthor = {Pilcher, Janine and Holliday, Mark and Ebmeier, Stefan and McKinstry, Steve and Messaoudi, Fatiha and Weatherall, Mark and Beasley, Richard},\n\tyear = {2016},\n\tpages = {e000128},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"caswellsmith-hosking-cripps-holweg-matthews-holliday-maillot-fingleton-etal-referencerangesforserumperiostininapopulationwithoutasthmaorcopd-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Reference ranges for serum periostin in a population without asthma or copd.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Caswell-Smith, R.; Hosking, A.; Cripps, T.; Holweg, C.; Matthews, J; Holliday, M.; Maillot, C.; Fingleton, J.; Weatherall, M.; Braithwaite, I.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology</i>, 46.  2016.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1111/cea.12763\"\n     onclick=\"log_download('caswellsmith-hosking-cripps-holweg-matthews-holliday-maillot-fingleton-etal-referencerangesforserumperiostininapopulationwithoutasthmaorcopd-2016', 'http://doi.org/10.1111/cea.12763', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/caswellsmith-hosking-cripps-holweg-matthews-holliday-maillot-fingleton-etal-referencerangesforserumperiostininapopulationwithoutasthmaorcopd-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('caswellsmith-hosking-cripps-holweg-matthews-holliday-maillot-fingleton-etal-referencerangesforserumperiostininapopulationwithoutasthmaorcopd-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{caswell-smith_reference_2016,\n\ttitle = {Reference ranges for serum periostin in a population without asthma or copd},\n\tvolume = {46},\n\tdoi = {10.1111/cea.12763},\n\tjournal = {Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},\n\tauthor = {Caswell-Smith, Rachel and Hosking, Alexander and Cripps, Terrianne and Holweg, Cécile and Matthews, J and Holliday, Mark and Maillot, Corentin and Fingleton, James and Weatherall, Mark and Braithwaite, Irene and Beasley, Richard},\n\tyear = {2016},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"braithwaite-williams-power-pilcher-weatherall-baines-moynihan-kempsford-etal-randomiseddoubleblindplacebocontrolledcrossoversingledosestudyofthebronchodilatordurationofactionofcombinationfluticasonefuroatevilanterolinhalerinadultasthma-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Randomised, double-blind, placebo-controlled, cross-over single dose study of the bronchodilator duration of action of combination fluticasone furoate/vilanterol inhaler in adult asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Braithwaite, I.; Williams, M.; Power, S.; Pilcher, J.; Weatherall, M.; Baines, A.; Moynihan, J.; Kempsford, R.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Respiratory Medicine</i>, 119: 115–121.  2016.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.rmed.2016.09.006\"\n     onclick=\"log_download('braithwaite-williams-power-pilcher-weatherall-baines-moynihan-kempsford-etal-randomiseddoubleblindplacebocontrolledcrossoversingledosestudyofthebronchodilatordurationofactionofcombinationfluticasonefuroatevilanterolinhalerinadultasthma-2016', 'http://doi.org/10.1016/j.rmed.2016.09.006', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/braithwaite-williams-power-pilcher-weatherall-baines-moynihan-kempsford-etal-randomiseddoubleblindplacebocontrolledcrossoversingledosestudyofthebronchodilatordurationofactionofcombinationfluticasonefuroatevilanterolinhalerinadultasthma-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('braithwaite-williams-power-pilcher-weatherall-baines-moynihan-kempsford-etal-randomiseddoubleblindplacebocontrolledcrossoversingledosestudyofthebronchodilatordurationofactionofcombinationfluticasonefuroatevilanterolinhalerinadultasthma-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{braithwaite_randomised_2016,\n\ttitle = {Randomised, double-blind, placebo-controlled, cross-over single dose study of the bronchodilator duration of action of combination fluticasone furoate/vilanterol inhaler in adult asthma},\n\tvolume = {119},\n\tdoi = {10.1016/j.rmed.2016.09.006},\n\tjournal = {Respiratory Medicine},\n\tauthor = {Braithwaite, Irene and Williams, Mathew and Power, Sharon and Pilcher, Janine and Weatherall, Mark and Baines, Amanda and Moynihan, Jackie and Kempsford, Rodger and Beasley, Richard},\n\tyear = {2016},\n\tpages = {115--121},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"riley-hunt-mcdouall-waqanivavalagi-braithwaite-weatherall-stanley-beasley-etal-pilotstudyoffeasibilityofarandomisedcontrolledtrialofasthmariskwithparacetamolversusibuprofenuseininfancy-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Riley, J.; Hunt, A.; McDouall, A.; Waqanivavalagi, S.; Braithwaite, I.; Weatherall, M.; Stanley, T.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Mitchell, E.;  and R Dalziel, S.\n</span>\n\n  \n\n</span>\n\n  <i>The New Zealand medical journal</i>, 129: 30–42.  2016.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/riley-hunt-mcdouall-waqanivavalagi-braithwaite-weatherall-stanley-beasley-etal-pilotstudyoffeasibilityofarandomisedcontrolledtrialofasthmariskwithparacetamolversusibuprofenuseininfancy-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('riley-hunt-mcdouall-waqanivavalagi-braithwaite-weatherall-stanley-beasley-etal-pilotstudyoffeasibilityofarandomisedcontrolledtrialofasthmariskwithparacetamolversusibuprofenuseininfancy-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{riley_pilot_2016,\n\ttitle = {Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy},\n\tvolume = {129},\n\tjournal = {The New Zealand medical journal},\n\tauthor = {Riley, Judith and Hunt, Anna and McDouall, Alice and Waqanivavalagi, Steve and Braithwaite, Irene and Weatherall, Mark and Stanley, Thorsten and Beasley, Richard and Mitchell, Edwin and R Dalziel, Stuart},\n\tyear = {2016},\n\tpages = {30--42},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2015\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2015')\"\n      onkeypress=\"toggleGroup('group_2015')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2015</span>\n      <span class=\"bibbase_group_count\">\n        \n        (4)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"pilcher-shirtcliffe-patel-mckinstry-cripps-weatherall-beasley-threemonthvalidationofaturbuhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Three-month validation of a turbuhaler electronic monitoring device: Implications for asthma clinical trial use.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Pilcher, J.; Shirtcliffe, P.; Patel, M.; McKinstry, S.; Cripps, T.; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>BMJ Open Respiratory Research</i>, 2: e000097.  2015.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1136/bmjresp-2015-000097\"\n     onclick=\"log_download('pilcher-shirtcliffe-patel-mckinstry-cripps-weatherall-beasley-threemonthvalidationofaturbuhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2015', 'http://doi.org/10.1136/bmjresp-2015-000097', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/pilcher-shirtcliffe-patel-mckinstry-cripps-weatherall-beasley-threemonthvalidationofaturbuhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('pilcher-shirtcliffe-patel-mckinstry-cripps-weatherall-beasley-threemonthvalidationofaturbuhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{pilcher_three-month_2015,\n\ttitle = {Three-month validation of a turbuhaler electronic monitoring device: {Implications} for asthma clinical trial use},\n\tvolume = {2},\n\tdoi = {10.1136/bmjresp-2015-000097},\n\tjournal = {BMJ Open Respiratory Research},\n\tauthor = {Pilcher, Janine and Shirtcliffe, Philippa and Patel, Mitesh and McKinstry, Steve and Cripps, Terrianne and Weatherall, Mark and Beasley, Richard},\n\tyear = {2015},\n\tpages = {e000097},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"strachan-atkhaled-foliaki-mallol-odhiambo-pearce-williams-group-siblingsasthmarhinoconjunctivitisandeczemaaworldwideperspectivefromtheinternationalstudyofasthmaandallergiesinchildhood-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Siblings, asthma, rhinoconjunctivitis and eczema: a worldwide perspective from the International Study of Asthma and Allergies in Childhood.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Strachan, D P; Aït‐Khaled, N; Foliaki, S; Mallol, J; Odhiambo, J; Pearce, N; Williams, H C;  and Group, I. P. T. S.\n</span>\n\n  \n\n</span>\n\n  <i>Clinical & Experimental Allergy</i>, 45(1): 126–136.  2015.\n  <span class=\"note\">Number: 1 Publisher: Wiley Online Library</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/strachan-atkhaled-foliaki-mallol-odhiambo-pearce-williams-group-siblingsasthmarhinoconjunctivitisandeczemaaworldwideperspectivefromtheinternationalstudyofasthmaandallergiesinchildhood-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('strachan-atkhaled-foliaki-mallol-odhiambo-pearce-williams-group-siblingsasthmarhinoconjunctivitisandeczemaaworldwideperspectivefromtheinternationalstudyofasthmaandallergiesinchildhood-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{strachan_siblings_2015,\n\ttitle = {Siblings, asthma, rhinoconjunctivitis and eczema: a worldwide perspective from the {International} {Study} of {Asthma} and {Allergies} in {Childhood}},\n\tvolume = {45},\n\tissn = {0954-7894},\n\tnumber = {1},\n\tjournal = {Clinical \\&amp; Experimental Allergy},\n\tauthor = {Strachan, D P and Aït‐Khaled, N and Foliaki, S and Mallol, J and Odhiambo, J and Pearce, N and Williams, H C and Group, ISAAC Phase Three Study},\n\tyear = {2015},\n\tnote = {Number: 1\nPublisher: Wiley Online Library},\n\tpages = {126--136},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-semprini-mitchell-riskfactorsforasthmaispreventionpossible-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Risk factors for asthma: Is prevention possible?.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Semprini, A.;  and Mitchell, E.\n</span>\n\n  \n\n</span>\n\n  <i>Lancet (London, England)</i>, 386: 1075–1085.  2015.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1016/S0140-6736(15)00156-7\"\n     onclick=\"log_download('beasley-semprini-mitchell-riskfactorsforasthmaispreventionpossible-2015', 'http://doi.org/10.1016/S0140-6736(15)00156-7', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-semprini-mitchell-riskfactorsforasthmaispreventionpossible-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-semprini-mitchell-riskfactorsforasthmaispreventionpossible-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_risk_2015,\n\ttitle = {Risk factors for asthma: {Is} prevention possible?},\n\tvolume = {386},\n\tdoi = {10.1016/S0140-6736(15)00156-7},\n\tjournal = {Lancet (London, England)},\n\tauthor = {Beasley, Richard and Semprini, Alex and Mitchell, Edwin},\n\tyear = {2015},\n\tpages = {1075--1085},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"riley-braithwaite-shirtcliffe-caswellsmith-hunt-bowden-power-stanley-etal-randomizedcontrolledtrialofasthmariskwithparacetamoluseininfancyafeasibilitystudy-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Randomized controlled trial of asthma risk with paracetamol use in infancy–a feasibility study.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Riley, J; Braithwaite, I; Shirtcliffe, P; Caswell‐Smith, R; Hunt, A; Bowden, V; Power, S; Stanley, T; Crane, J;  and Ingham, T\n</span>\n\n  \n\n</span>\n\n  <i>Clinical & Experimental Allergy</i>, 45(2): 448–456.  2015.\n  <span class=\"note\">Number: 2 Publisher: Wiley Online Library</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/riley-braithwaite-shirtcliffe-caswellsmith-hunt-bowden-power-stanley-etal-randomizedcontrolledtrialofasthmariskwithparacetamoluseininfancyafeasibilitystudy-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('riley-braithwaite-shirtcliffe-caswellsmith-hunt-bowden-power-stanley-etal-randomizedcontrolledtrialofasthmariskwithparacetamoluseininfancyafeasibilitystudy-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{riley_randomized_2015,\n\ttitle = {Randomized controlled trial of asthma risk with paracetamol use in infancy–a feasibility study},\n\tvolume = {45},\n\tissn = {0954-7894},\n\tnumber = {2},\n\tjournal = {Clinical \\&amp; Experimental Allergy},\n\tauthor = {Riley, J and Braithwaite, I and Shirtcliffe, P and Caswell‐Smith, R and Hunt, A and Bowden, V and Power, S and Stanley, T and Crane, J and Ingham, T},\n\tyear = {2015},\n\tnote = {Number: 2\nPublisher: Wiley Online Library},\n\tpages = {448--456},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2014\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2014')\"\n      onkeypress=\"toggleGroup('group_2014')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2014</span>\n      <span class=\"bibbase_group_count\">\n        \n        (4)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"weatherall-ioannides-braithwaite-beasley-theassociationbetweenparacetamoluseandasthmacausationorcoincidence-2014\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  The association between paracetamol use and asthma: Causation or coincidence?.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Weatherall, M.; Ioannides, S.; Braithwaite, I.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology</i>, 45.  2014.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1111/cea.12410\"\n     onclick=\"log_download('weatherall-ioannides-braithwaite-beasley-theassociationbetweenparacetamoluseandasthmacausationorcoincidence-2014', 'http://doi.org/10.1111/cea.12410', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/weatherall-ioannides-braithwaite-beasley-theassociationbetweenparacetamoluseandasthmacausationorcoincidence-2014\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('weatherall-ioannides-braithwaite-beasley-theassociationbetweenparacetamoluseandasthmacausationorcoincidence-2014')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{weatherall_association_2014,\n\ttitle = {The association between paracetamol use and asthma: {Causation} or coincidence?},\n\tvolume = {45},\n\tdoi = {10.1111/cea.12410},\n\tjournal = {Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},\n\tauthor = {Weatherall, Mark and Ioannides, Sally and Braithwaite, Irene and Beasley, Richard},\n\tyear = {2014},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"riley-braithwaite-shirtcliffe-caswellsmith-hunt-bowden-power-stanley-etal-randomizedcontrolledtrialofasthmariskwithparacetamoluseininfancyafeasibilitystudy-2014\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Randomized Controlled Trial Of Asthma Risk With Paracetamol Use In Infancy - A Feasibility Study.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Riley, J.; Braithwaite, I.; Shirtcliffe, P.; Caswell-Smith, R.; Hunt, A.; Bowden, V.; Power, S.; Stanley, T.; Crane, J.; Ingham, T.; Weatherall, M.; Mitchell, E.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology</i>, 45.  2014.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1111/cea.12433\"\n     onclick=\"log_download('riley-braithwaite-shirtcliffe-caswellsmith-hunt-bowden-power-stanley-etal-randomizedcontrolledtrialofasthmariskwithparacetamoluseininfancyafeasibilitystudy-2014', 'http://doi.org/10.1111/cea.12433', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/riley-braithwaite-shirtcliffe-caswellsmith-hunt-bowden-power-stanley-etal-randomizedcontrolledtrialofasthmariskwithparacetamoluseininfancyafeasibilitystudy-2014\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('riley-braithwaite-shirtcliffe-caswellsmith-hunt-bowden-power-stanley-etal-randomizedcontrolledtrialofasthmariskwithparacetamoluseininfancyafeasibilitystudy-2014')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{riley_randomized_2014,\n\ttitle = {Randomized {Controlled} {Trial} {Of} {Asthma} {Risk} {With} {Paracetamol} {Use} {In} {Infancy} - {A} {Feasibility} {Study}.},\n\tvolume = {45},\n\tdoi = {10.1111/cea.12433},\n\tjournal = {Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},\n\tauthor = {Riley, Judith and Braithwaite, Irene and Shirtcliffe, Philippa and Caswell-Smith, Rachel and Hunt, Anna and Bowden, Vanessa and Power, Sharon and Stanley, Thorsten and Crane, Julian and Ingham, Tristram and Weatherall, Mark and Mitchell, Edwin and Beasley, Richard},\n\tyear = {2014},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"ioannides-williams-jefferies-perrin-weatherall-siebers-crane-patel-etal-randomisedplacebocontrolledstudyoftheeffectofparacetamolonasthmaseverityinadults-2014\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Ioannides, S.; Williams, M.; Jefferies, S.; Perrin, K.; Weatherall, M.; Siebers, R.; Crane, J.; Patel, M.; Travers, J.; Shirtcliffe, P.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>BMJ open</i>, 4: e004324.  2014.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1136/bmjopen-2013-004324\"\n     onclick=\"log_download('ioannides-williams-jefferies-perrin-weatherall-siebers-crane-patel-etal-randomisedplacebocontrolledstudyoftheeffectofparacetamolonasthmaseverityinadults-2014', 'http://doi.org/10.1136/bmjopen-2013-004324', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/ioannides-williams-jefferies-perrin-weatherall-siebers-crane-patel-etal-randomisedplacebocontrolledstudyoftheeffectofparacetamolonasthmaseverityinadults-2014\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('ioannides-williams-jefferies-perrin-weatherall-siebers-crane-patel-etal-randomisedplacebocontrolledstudyoftheeffectofparacetamolonasthmaseverityinadults-2014')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{ioannides_randomised_2014,\n\ttitle = {Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults},\n\tvolume = {4},\n\tdoi = {10.1136/bmjopen-2013-004324},\n\tjournal = {BMJ open},\n\tauthor = {Ioannides, Sally and Williams, Mathew and Jefferies, Sarah and Perrin, Kyle and Weatherall, Mark and Siebers, Robert and Crane, Julian and Patel, Mitesh and Travers, Justin and Shirtcliffe, Philippa and Beasley, Richard},\n\tyear = {2014},\n\tpages = {e004324},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"patel-pilcher-reddel-qi-mackey-tranquilino-shaw-black-etal-predictorsofsevereexacerbationspoorasthmacontrolandagonistoveruseinasthmaforpatientswithasthma-2014\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Predictors of Severe Exacerbations, Poor Asthma Control, and β-Agonist Overuse in Asthma for Patients with Asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Patel, M.; Pilcher, J.; Reddel, H.; Qi, V.; Mackey, B.; Tranquilino, T.; Shaw, D.; Black, P.; Weatherall, M.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>The Journal of Allergy and Clinical Immunology: In Practice</i>, 2.  2014.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaip.2014.06.001\"\n     onclick=\"log_download('patel-pilcher-reddel-qi-mackey-tranquilino-shaw-black-etal-predictorsofsevereexacerbationspoorasthmacontrolandagonistoveruseinasthmaforpatientswithasthma-2014', 'http://doi.org/10.1016/j.jaip.2014.06.001', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/patel-pilcher-reddel-qi-mackey-tranquilino-shaw-black-etal-predictorsofsevereexacerbationspoorasthmacontrolandagonistoveruseinasthmaforpatientswithasthma-2014\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('patel-pilcher-reddel-qi-mackey-tranquilino-shaw-black-etal-predictorsofsevereexacerbationspoorasthmacontrolandagonistoveruseinasthmaforpatientswithasthma-2014')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{patel_predictors_2014,\n\ttitle = {Predictors of {Severe} {Exacerbations}, {Poor} {Asthma} {Control}, and β-{Agonist} {Overuse} in {Asthma} for {Patients} with {Asthma}},\n\tvolume = {2},\n\tdoi = {10.1016/j.jaip.2014.06.001},\n\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\n\tauthor = {Patel, Mitesh and Pilcher, Janine and Reddel, Helen and Qi, Victoria and Mackey, Bill and Tranquilino, Tyronne and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard},\n\tyear = {2014},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2013\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2013')\"\n      onkeypress=\"toggleGroup('group_2013')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2013</span>\n      <span class=\"bibbase_group_count\">\n        \n        (4)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"pilcher-patel-pritchard-black-weatherall-beasley-useofreliableelectronicmonitorsistheoptimalmethodtoassesspatternsofinhaledasthmamedicationuse-2013\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  USE OF RELIABLE ELECTRONIC MONITORS IS THE OPTIMAL METHOD TO ASSESS PATTERNS OF INHALED ASTHMA MEDICATION USE.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Pilcher, J; Patel, M; Pritchard, A; Black, P; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Respirology</i>, 18: 45.  2013.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/pilcher-patel-pritchard-black-weatherall-beasley-useofreliableelectronicmonitorsistheoptimalmethodtoassesspatternsofinhaledasthmamedicationuse-2013\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('pilcher-patel-pritchard-black-weatherall-beasley-useofreliableelectronicmonitorsistheoptimalmethodtoassesspatternsofinhaledasthmamedicationuse-2013')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{pilcher_use_2013,\n\ttitle = {{USE} {OF} {RELIABLE} {ELECTRONIC} {MONITORS} {IS} {THE} {OPTIMAL} {METHOD} {TO} {ASSESS} {PATTERNS} {OF} {INHALED} {ASTHMA} {MEDICATION} {USE}},\n\tvolume = {18},\n\tjournal = {Respirology},\n\tauthor = {Pilcher, J and Patel, M and Pritchard, A and Black, P and Weatherall, Mark and Beasley, Richard},\n\tyear = {2013},\n\tpages = {45},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"patel-pilcher-travers-perrin-shaw-black-weatherall-beasley-useofmetereddoseinhalerelectronicmonitoringinarealworldasthmarandomizedcontrolledtrial-2013\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Use of Metered-Dose Inhaler Electronic Monitoring in a Real-World Asthma Randomized Controlled Trial.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Patel, M.; Pilcher, J.; Travers, J.; Perrin, K.; Shaw, D.; Black, P.; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>The journal of allergy and clinical immunology in practice</i>, 1: 83–91.  2013.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaip.2012.08.004\"\n     onclick=\"log_download('patel-pilcher-travers-perrin-shaw-black-weatherall-beasley-useofmetereddoseinhalerelectronicmonitoringinarealworldasthmarandomizedcontrolledtrial-2013', 'http://doi.org/10.1016/j.jaip.2012.08.004', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/patel-pilcher-travers-perrin-shaw-black-weatherall-beasley-useofmetereddoseinhalerelectronicmonitoringinarealworldasthmarandomizedcontrolledtrial-2013\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('patel-pilcher-travers-perrin-shaw-black-weatherall-beasley-useofmetereddoseinhalerelectronicmonitoringinarealworldasthmarandomizedcontrolledtrial-2013')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{patel_use_2013,\n\ttitle = {Use of {Metered}-{Dose} {Inhaler} {Electronic} {Monitoring} in a {Real}-{World} {Asthma} {Randomized} {Controlled} {Trial}},\n\tvolume = {1},\n\tdoi = {10.1016/j.jaip.2012.08.004},\n\tjournal = {The journal of allergy and clinical immunology in practice},\n\tauthor = {Patel, Mitesh and Pilcher, Janine and Travers, Justin and Perrin, Kyle and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard},\n\tyear = {2013},\n\tpages = {83--91},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"pilcher-patel-smith-davies-harwood-weatherall-beasley-singlebudesonideformoterolinhalerasmaintenanceandrelievertherapyisbeneficialinmaoriasthma-2013\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  SINGLE BUDESONIDE/FORMOTEROL INHALER AS MAINTENANCE AND RELIEVER THERAPY IS BENEFICIAL IN MAORI ASTHMA.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Pilcher, J; Patel, M; Smith, A; Davies, C.; Harwood, M.; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Respirology</i>, 18: 44.  2013.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/pilcher-patel-smith-davies-harwood-weatherall-beasley-singlebudesonideformoterolinhalerasmaintenanceandrelievertherapyisbeneficialinmaoriasthma-2013\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('pilcher-patel-smith-davies-harwood-weatherall-beasley-singlebudesonideformoterolinhalerasmaintenanceandrelievertherapyisbeneficialinmaoriasthma-2013')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{pilcher_single_2013,\n\ttitle = {{SINGLE} {BUDESONIDE}/{FORMOTEROL} {INHALER} {AS} {MAINTENANCE} {AND} {RELIEVER} {THERAPY} {IS} {BENEFICIAL} {IN} {MAORI} {ASTHMA}},\n\tvolume = {18},\n\tjournal = {Respirology},\n\tauthor = {Pilcher, J and Patel, M and Smith, A and Davies, Cheryl and Harwood, Matire and Weatherall, Mark and Beasley, Richard},\n\tyear = {2013},\n\tpages = {44},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"patel-pilcher-munro-hosking-pritchard-shaw-black-weatherall-etal-shortactingagonistuseasamarkerofcurrentasthmacontrol-2013\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Short-Acting β-Agonist Use As a Marker of Current Asthma Control.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Patel, M.; Pilcher, J.; Munro, C.; Hosking, A.; Pritchard, A.; Shaw, D.; Black, P.; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>The Journal of Allergy and Clinical Immunology: In Practice</i>, 1: 370–377.  2013.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaip.2013.04.008\"\n     onclick=\"log_download('patel-pilcher-munro-hosking-pritchard-shaw-black-weatherall-etal-shortactingagonistuseasamarkerofcurrentasthmacontrol-2013', 'http://doi.org/10.1016/j.jaip.2013.04.008', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/patel-pilcher-munro-hosking-pritchard-shaw-black-weatherall-etal-shortactingagonistuseasamarkerofcurrentasthmacontrol-2013\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('patel-pilcher-munro-hosking-pritchard-shaw-black-weatherall-etal-shortactingagonistuseasamarkerofcurrentasthmacontrol-2013')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{patel_short-acting_2013,\n\ttitle = {Short-{Acting} β-{Agonist} {Use} {As} a {Marker} of {Current} {Asthma} {Control}},\n\tvolume = {1},\n\tdoi = {10.1016/j.jaip.2013.04.008},\n\tjournal = {The Journal of Allergy and Clinical Immunology: In Practice},\n\tauthor = {Patel, Mitesh and Pilcher, Janine and Munro, Claire and Hosking, Alexander and Pritchard, Alison and Shaw, Dominick and Black, Peter and Weatherall, Mark and Beasley, Richard},\n\tyear = {2013},\n\tpages = {370--377},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2012\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2012')\"\n      onkeypress=\"toggleGroup('group_2012')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2012</span>\n      <span class=\"bibbase_group_count\">\n        \n        (3)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"mitchell-beasley-keil-montefort-odhiambo-theassociationbetweentobaccoandtheriskofasthmarhinoconjunctivitisandeczemainchildrenandadolescentsanalysesfromphasethreeoftheisaacprogramme-2012\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  The association between tobacco and the risk of asthma, rhinoconjunctivitis and eczema in children and adolescents: analyses from Phase Three of the ISAAC programme.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Mitchell, E.; <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; Keil, U.; Montefort, S.;  and Odhiambo, J.\n</span>\n\n  \n\n</span>\n\n  <i>Thorax</i>, 67: 941–949.  2012.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1136/thoraxjnl-2011-200901\"\n     onclick=\"log_download('mitchell-beasley-keil-montefort-odhiambo-theassociationbetweentobaccoandtheriskofasthmarhinoconjunctivitisandeczemainchildrenandadolescentsanalysesfromphasethreeoftheisaacprogramme-2012', 'http://doi.org/10.1136/thoraxjnl-2011-200901', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/mitchell-beasley-keil-montefort-odhiambo-theassociationbetweentobaccoandtheriskofasthmarhinoconjunctivitisandeczemainchildrenandadolescentsanalysesfromphasethreeoftheisaacprogramme-2012\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('mitchell-beasley-keil-montefort-odhiambo-theassociationbetweentobaccoandtheriskofasthmarhinoconjunctivitisandeczemainchildrenandadolescentsanalysesfromphasethreeoftheisaacprogramme-2012')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{mitchell_association_2012,\n\ttitle = {The association between tobacco and the risk of asthma, rhinoconjunctivitis and eczema in children and adolescents: analyses from {Phase} {Three} of the {ISAAC} programme},\n\tvolume = {67},\n\tdoi = {10.1136/thoraxjnl-2011-200901},\n\tjournal = {Thorax},\n\tauthor = {Mitchell, Edwin and Beasley, Richard and Keil, Ulrich and Montefort, Stephen and Odhiambo, Joseph},\n\tyear = {2012},\n\tpages = {941--949},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"patel-pilcher-chan-perrin-black-beasley-sixmonthinvitrovalidationofametereddoseinhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2012\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Six-month in vitro validation of a metered-dose inhaler electronic monitoring device: Implications for asthma clinical trial use.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Patel, M.; Pilcher, J.; Chan, A.; Perrin, K.; Black, P.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>The Journal of allergy and clinical immunology</i>, 130.  2012.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1016/j.jaci.2012.06.037\"\n     onclick=\"log_download('patel-pilcher-chan-perrin-black-beasley-sixmonthinvitrovalidationofametereddoseinhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2012', 'http://doi.org/10.1016/j.jaci.2012.06.037', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/patel-pilcher-chan-perrin-black-beasley-sixmonthinvitrovalidationofametereddoseinhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2012\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('patel-pilcher-chan-perrin-black-beasley-sixmonthinvitrovalidationofametereddoseinhalerelectronicmonitoringdeviceimplicationsforasthmaclinicaltrialuse-2012')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{patel_six-month_2012,\n\ttitle = {Six-month in vitro validation of a metered-dose inhaler electronic monitoring device: {Implications} for asthma clinical trial use},\n\tvolume = {130},\n\tdoi = {10.1016/j.jaci.2012.06.037},\n\tjournal = {The Journal of allergy and clinical immunology},\n\tauthor = {Patel, Mitesh and Pilcher, Janine and Chan, Amy and Perrin, Kyle and Black, Peter and Beasley, Richard},\n\tyear = {2012},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-fingleton-weatherall-restrictionoflabausetocombinationicslabainhalertherapyinasthma-2012\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Restriction of LABA use to combination ICS/LABA inhaler therapy in asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.; Fingleton, J.;  and Weatherall, M.\n</span>\n\n  \n\n</span>\n\n  <i>Thorax</i>, 68.  2012.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1136/thoraxjnl-2012-202483\"\n     onclick=\"log_download('beasley-fingleton-weatherall-restrictionoflabausetocombinationicslabainhalertherapyinasthma-2012', 'http://doi.org/10.1136/thoraxjnl-2012-202483', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-fingleton-weatherall-restrictionoflabausetocombinationicslabainhalertherapyinasthma-2012\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-fingleton-weatherall-restrictionoflabausetocombinationicslabainhalertherapyinasthma-2012')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_restriction_2012,\n\ttitle = {Restriction of {LABA} use to combination {ICS}/{LABA} inhaler therapy in asthma},\n\tvolume = {68},\n\tdoi = {10.1136/thoraxjnl-2012-202483},\n\tjournal = {Thorax},\n\tauthor = {Beasley, Richard and Fingleton, James and Weatherall, Mark},\n\tyear = {2012},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2011\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2011')\"\n      onkeypress=\"toggleGroup('group_2011')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2011</span>\n      <span class=\"bibbase_group_count\">\n        \n        (1)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"perrin-wijesinghe-healy-wadsworth-bowditch-bibby-baker-weatherall-etal-randomisedcontrolledtrialofhighconcentrationversustitratedoxygentherapyinsevereexacerbationsofasthma-2011\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Perrin, K.; Wijesinghe, M.; Healy, B.; Wadsworth, K.; Bowditch, R.; Bibby, S.; Baker, T.; Weatherall, M.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>Thorax</i>, 66: 937–941.  2011.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n  <a href=\"http://doi.org/10.1136/thx.2010.155259\"\n     onclick=\"log_download('perrin-wijesinghe-healy-wadsworth-bowditch-bibby-baker-weatherall-etal-randomisedcontrolledtrialofhighconcentrationversustitratedoxygentherapyinsevereexacerbationsofasthma-2011', 'http://doi.org/10.1136/thx.2010.155259', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/perrin-wijesinghe-healy-wadsworth-bowditch-bibby-baker-weatherall-etal-randomisedcontrolledtrialofhighconcentrationversustitratedoxygentherapyinsevereexacerbationsofasthma-2011\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('perrin-wijesinghe-healy-wadsworth-bowditch-bibby-baker-weatherall-etal-randomisedcontrolledtrialofhighconcentrationversustitratedoxygentherapyinsevereexacerbationsofasthma-2011')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{perrin_randomised_2011,\n\ttitle = {Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma},\n\tvolume = {66},\n\tdoi = {10.1136/thx.2010.155259},\n\tjournal = {Thorax},\n\tauthor = {Perrin, Kyle and Wijesinghe, Meme and Healy, Bridget and Wadsworth, Kirsten and Bowditch, Richard and Bibby, Susan and Baker, Tanya and Weatherall, Mark and Beasley, Richard},\n\tyear = {2011},\n\tpages = {937--941},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2005\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2005')\"\n      onkeypress=\"toggleGroup('group_2005')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2005</span>\n      <span class=\"bibbase_group_count\">\n        \n        (1)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"holt-efficacyofbupropionintheindigenousmaoripopulationinnewzealand-2005\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://thorax.bmj.com/cgi/doi/10.1136/thx.2004.030239\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'holt-efficacyofbupropionintheindigenousmaoripopulationinnewzealand-2005', 'http://thorax.bmj.com/cgi/doi/10.1136/thx.2004.030239', event);\">\n    Efficacy of bupropion in the indigenous Maori population in New Zealand.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Holt, S\n</span>\n\n  \n\n</span>\n\n  <i>Thorax</i>, 60(2): 120–123. February 2005.\n  <span class=\"note\">Number: 2</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://thorax.bmj.com/cgi/doi/10.1136/thx.2004.030239\"\n     onclick=\"log_download('holt-efficacyofbupropionintheindigenousmaoripopulationinnewzealand-2005', 'http://thorax.bmj.com/cgi/doi/10.1136/thx.2004.030239', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Efficacy of bupropion in the indigenous Maori population in New Zealand [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1136/thx.2004.030239\"\n     onclick=\"log_download('holt-efficacyofbupropionintheindigenousmaoripopulationinnewzealand-2005', 'http://doi.org/10.1136/thx.2004.030239', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/holt-efficacyofbupropionintheindigenousmaoripopulationinnewzealand-2005\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('holt-efficacyofbupropionintheindigenousmaoripopulationinnewzealand-2005')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{holt_efficacy_2005,\n\ttitle = {Efficacy of bupropion in the indigenous {Maori} population in {New} {Zealand}},\n\tvolume = {60},\n\tissn = {0040-6376},\n\turl = {http://thorax.bmj.com/cgi/doi/10.1136/thx.2004.030239},\n\tdoi = {10.1136/thx.2004.030239},\n\tlanguage = {en},\n\tnumber = {2},\n\turldate = {2020-07-13},\n\tjournal = {Thorax},\n\tauthor = {Holt, S},\n\tmonth = feb,\n\tyear = {2005},\n\tnote = {Number: 2},\n\tpages = {120--123},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2000\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2000')\"\n      onkeypress=\"toggleGroup('group_2000')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2000</span>\n      <span class=\"bibbase_group_count\">\n        \n        (1)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"dsouza-slater-fox-fox-tekaru-gemmell-ratima-pearce-etal-asthmamorbidity6yrsafteraneffectiveasthmaselfmanagementprogrammeinamaoricommunity-2000\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/content/15/3/464\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'dsouza-slater-fox-fox-tekaru-gemmell-ratima-pearce-etal-asthmamorbidity6yrsafteraneffectiveasthmaselfmanagementprogrammeinamaoricommunity-2000', 'http://erj.ersjournals.com/content/15/3/464', event);\">\n    Asthma morbidity 6 yrs after an effective asthma self-management programme in a Maori community.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  D'souza, W.; Slater, T; Fox, C; Fox, B; Te Karu, H; Gemmell, T; Ratima, M.; Pearce, N.;  and <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>, 15(3): 464–469. March 2000.\n  <span class=\"note\">Number: 3</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/content/15/3/464\"\n     onclick=\"log_download('dsouza-slater-fox-fox-tekaru-gemmell-ratima-pearce-etal-asthmamorbidity6yrsafteraneffectiveasthmaselfmanagementprogrammeinamaoricommunity-2000', 'http://erj.ersjournals.com/content/15/3/464', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Asthma morbidity 6 yrs after an effective asthma self-management programme in a Maori community [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1034/j.1399-3003.2000.15.07.x\"\n     onclick=\"log_download('dsouza-slater-fox-fox-tekaru-gemmell-ratima-pearce-etal-asthmamorbidity6yrsafteraneffectiveasthmaselfmanagementprogrammeinamaoricommunity-2000', 'http://doi.org/10.1034/j.1399-3003.2000.15.07.x', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/dsouza-slater-fox-fox-tekaru-gemmell-ratima-pearce-etal-asthmamorbidity6yrsafteraneffectiveasthmaselfmanagementprogrammeinamaoricommunity-2000\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('dsouza-slater-fox-fox-tekaru-gemmell-ratima-pearce-etal-asthmamorbidity6yrsafteraneffectiveasthmaselfmanagementprogrammeinamaoricommunity-2000')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{dsouza_asthma_2000,\n\ttitle = {Asthma morbidity 6 yrs after an effective asthma self-management programme in a {Maori} community},\n\tvolume = {15},\n\tissn = {0903-1936, 1399-3003},\n\turl = {http://erj.ersjournals.com/content/15/3/464},\n\tdoi = {10.1034/j.1399-3003.2000.15.07.x},\n\tlanguage = {en},\n\tnumber = {3},\n\turldate = {2020-07-13},\n\tjournal = {European Respiratory Journal},\n\tauthor = {D&#x27;souza, W.j and Slater, T and Fox, C and Fox, B and Te Karu, H and Gemmell, T and Ratima, M.m and Pearce, N.e and Beasley, R.b},\n\tmonth = mar,\n\tyear = {2000},\n\tnote = {Number: 3},\n\tpages = {464--469},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_1993\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_1993')\"\n      onkeypress=\"toggleGroup('group_1993')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>1993</span>\n      <span class=\"bibbase_group_count\">\n        \n        (1)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"beasley-dsouza-tekaru-fox-harper-robson-howdenchapman-crane-etal-trialofanasthmaactionplaninthemaoricommunityofthewairarapa-1993\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  Trial of an asthma action plan in the Maori community of the Wairarapa.\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  <a class=\"bibbase author link\" href=\"https://www.mrinz.ac.nz/\">Beasley, R.</a>; D'Souza, W.; Te Karu, H.; Fox, C.; Harper, M.; Robson, B.; Howden-Chapman, P.; Crane, J.; Burgess, C.;  and Woodman, K.\n</span>\n\n  \n\n</span>\n\n  <i>The New Zealand Medical Journal</i>, 106(961): 336–338. August 1993.\n  <span class=\"note\">Number: 961</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-dsouza-tekaru-fox-harper-robson-howdenchapman-crane-etal-trialofanasthmaactionplaninthemaoricommunityofthewairarapa-1993\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-dsouza-tekaru-fox-harper-robson-howdenchapman-crane-etal-trialofanasthmaactionplaninthemaoricommunityofthewairarapa-1993')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_trial_1993,\n\ttitle = {Trial of an asthma action plan in the {Maori} community of the {Wairarapa}},\n\tvolume = {106},\n\tissn = {0028-8446},\n\tabstract = {AIMS: An asthma action plan has been tested in a study conducted by Wairarapa Maori community health workers and the Wellington asthma research group. There were several distinctive features of the project, including the programme of marae-based asthma clinics, and the partnership between the researchers and the Maori community groups. This paper describes the process by which the study was conducted since this experience may be relevant to future Maori health research projects.\nMETHODS: The programme was launched with a series of hui at marae in the Wairarapa, and marae-based clinics were set up. These were followed up by further support from the Maori community health workers who helped people to keep diaries to monitor their asthma, and generally maintained contact. The severity of asthma in the participants was compared for a two-month period before the action plan was introduced, and for a four-month period after the plan was introduced.\nRESULTS: There was a high participation rate, with 91\\% (63/69) of participants finishing the programme, 75\\% of whom adequately completed their daily asthma diaries. Asthma control improved significantly in the participants. They commented positively on the programme, and particularly on the marae-based clinics.\nCONCLUSIONS: The study was successful in terms of participation in the marae-based clinics, acceptance and use of the plan, and improvement in asthma control of the participants. The findings indicate what can be achieved when researchers and Maori community groups work in partnership.},\n\tlanguage = {eng},\n\tnumber = {961},\n\tjournal = {The New Zealand Medical Journal},\n\tauthor = {Beasley, R. and D&#x27;Souza, W. and Te Karu, H. and Fox, C. and Harper, M. and Robson, B. and Howden-Chapman, P. and Crane, J. and Burgess, C. and Woodman, K.},\n\tmonth = aug,\n\tyear = {1993},\n\tpmid = {8341475},\n\tnote = {Number: 961},\n\tkeywords = {Asthma, Community Health Workers, European Continental Ancestry Group, Humans, New Zealand, Oceanic Ancestry Group, Patient Acceptance of Health Care, Patient Education as Topic, Program Evaluation},\n\tpages = {336--338},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  AIMS: An asthma action plan has been tested in a study conducted by Wairarapa Maori community health workers and the Wellington asthma research group. There were several distinctive features of the project, including the programme of marae-based asthma clinics, and the partnership between the researchers and the Maori community groups. This paper describes the process by which the study was conducted since this experience may be relevant to future Maori health research projects. METHODS: The programme was launched with a series of hui at marae in the Wairarapa, and marae-based clinics were set up. These were followed up by further support from the Maori community health workers who helped people to keep diaries to monitor their asthma, and generally maintained contact. The severity of asthma in the participants was compared for a two-month period before the action plan was introduced, and for a four-month period after the plan was introduced. RESULTS: There was a high participation rate, with 91% (63/69) of participants finishing the programme, 75% of whom adequately completed their daily asthma diaries. Asthma control improved significantly in the participants. They commented positively on the programme, and particularly on the marae-based clinics. CONCLUSIONS: The study was successful in terms of participation in the marae-based clinics, acceptance and use of the plan, and improvement in asthma control of the participants. The findings indicate what can be achieved when researchers and Maori community groups work in partnership.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n\n\n\n  </div>\n\n\n  <!-- Modal -->\n\n  <!-- <iframe id=\"bibbase_network_frame\" -->\n  <!--         src=\"//bibbase.org/network/control\" -->\n  <!--         style=\"display: none;\"> -->\n  <!-- </iframe> -->\n\n</div>\n"}; document.write(bibbase_data.data);