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\n  \n 2020\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n \n Efficacy of a topical herbal and mineral formulation (Dynamiclear) for the treatment of herpes simplex labialis in the community setting: study protocol for a randomised, double-blind placebo-controlled trial.\n \n \n \n \n\n\n \n Armour, M.; Semprini, A.; Ee, C.; MacCullagh, L.; and Shortt, N.\n\n\n \n\n\n\n BMJ Open, 10(1): e031876. January 2020.\n \n\n\n\n
\n\n\n\n \n \n \"EfficacyPaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n  \n \n 3 downloads\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{armour_efficacy_2020,\n\ttitle = {Efficacy of a topical herbal and mineral formulation ({Dynamiclear}) for the treatment of herpes simplex labialis in the community setting: study protocol for a randomised, double-blind placebo-controlled trial},\n\tvolume = {10},\n\tissn = {2044-6055, 2044-6055},\n\tshorttitle = {Efficacy of a topical herbal and mineral formulation ({Dynamiclear}) for the treatment of herpes simplex labialis in the community setting},\n\turl = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2019-031876},\n\tdoi = {10.1136/bmjopen-2019-031876},\n\tabstract = {Introduction\n              Herpes simplex labialis (HSL) is a common infection that can cause painful lesions on the oral mucosa, commonly referred to as cold sores. Current biomedical treatments include topical aciclovir, which reduces the episode duration by an average of 0.5 days. This study will examine the efficacy and tolerability of an over-the-counter topical treatment, Dynamiclear in reducing duration and severity of HSL episodes.\n            \n            \n              Methods and analysis\n              \n                This prospective, randomised, double-blind, placebo-controlled, multi-centre trial will recruit a minimum of 292 adult participants across Australia and New Zealand who present with a cold sore within 48 hours of onset. They will be randomly allocated in a 2:1 ratio to receive either topical Dynamiclear (active) or placebo. Dynamiclear’s active ingredients are\n                Hypericum perforatum\n                ,\n                Calendula Officinalis\n                and copper sulfate. A single topical treatment of active or placebo will be applied by a pharmacy-based investigator, and participants will be provided with a viral swab kit to confirm presence of herpes virus 1 or 2 from ulcerated lesions. Participants will receive reminders by email and/or SMS to complete an online daily diary assessing their cold sore lesion using a visual guide, and recording other symptoms on numeric scales until healed. The primary outcome variable is median duration of HSL episode in days (participant evaluated) from presentation to return to normal skin. Secondary outcomes include severity of lesion pain, itching, burning and tingling during the symptomatic phase and proportion of lesions progressing to ulceration.\n              \n            \n            \n              Ethics and dissemination\n              Australian ethics approval from Western Sydney University Human Research Ethics Committee, ref: H12776. New Zealand Ethics approval from The Health and Disability Ethics Committees (HDEC) ref: 18/CEN/151. Results will be published in a peer-reviewed academic journal, presented at academic meetings and reported to participants\n            \n            \n              Trial registration numbers\n              Australia and New Zealand Clinical Trials Registry (ACTRN12618000890235); Universal Trial Number (UTN) (U1111-1233-2426).},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2021-05-05},\n\tjournal = {BMJ Open},\n\tauthor = {Armour, Mike and Semprini, Alex and Ee, Carolyn and MacCullagh, Lois and Shortt, Nick},\n\tmonth = jan,\n\tyear = {2020},\n\tpages = {e031876},\n}\n\n
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\n Introduction Herpes simplex labialis (HSL) is a common infection that can cause painful lesions on the oral mucosa, commonly referred to as cold sores. Current biomedical treatments include topical aciclovir, which reduces the episode duration by an average of 0.5 days. This study will examine the efficacy and tolerability of an over-the-counter topical treatment, Dynamiclear in reducing duration and severity of HSL episodes. Methods and analysis This prospective, randomised, double-blind, placebo-controlled, multi-centre trial will recruit a minimum of 292 adult participants across Australia and New Zealand who present with a cold sore within 48 hours of onset. They will be randomly allocated in a 2:1 ratio to receive either topical Dynamiclear (active) or placebo. Dynamiclear’s active ingredients are Hypericum perforatum , Calendula Officinalis and copper sulfate. A single topical treatment of active or placebo will be applied by a pharmacy-based investigator, and participants will be provided with a viral swab kit to confirm presence of herpes virus 1 or 2 from ulcerated lesions. Participants will receive reminders by email and/or SMS to complete an online daily diary assessing their cold sore lesion using a visual guide, and recording other symptoms on numeric scales until healed. The primary outcome variable is median duration of HSL episode in days (participant evaluated) from presentation to return to normal skin. Secondary outcomes include severity of lesion pain, itching, burning and tingling during the symptomatic phase and proportion of lesions progressing to ulceration. Ethics and dissemination Australian ethics approval from Western Sydney University Human Research Ethics Committee, ref: H12776. New Zealand Ethics approval from The Health and Disability Ethics Committees (HDEC) ref: 18/CEN/151. Results will be published in a peer-reviewed academic journal, presented at academic meetings and reported to participants Trial registration numbers Australia and New Zealand Clinical Trials Registry (ACTRN12618000890235); Universal Trial Number (UTN) (U1111-1233-2426).\n
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\n  \n 2019\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: A randomised controlled trial.\n \n \n \n\n\n \n Semprini, A.; Singer, J.; Braithwaite, I.; Shortt, N.; Thayabaran, D.; McConnell, M.; Weatherall, M.; and Beasley, R.\n\n\n \n\n\n\n BMJ Open, 9: e026201. 2019.\n \n\n\n\n
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@article{semprini_kanuka_2019,\n\ttitle = {Kanuka honey versus aciclovir for the topical treatment of herpes simplex labialis: {A} randomised controlled trial},\n\tvolume = {9},\n\tdoi = {10.1136/bmjopen-2018-026201},\n\tjournal = {BMJ Open},\n\tauthor = {Semprini, Alex and Singer, Joseph and Braithwaite, Irene and Shortt, Nick and Thayabaran, Darmiga and McConnell, Melanie and Weatherall, Mark and Beasley, Richard},\n\tyear = {2019},\n\tpages = {e026201},\n}\n\n
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\n  \n 2018\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n Successful Treatment of Actinic Keratosis with Kanuka Honey.\n \n \n \n\n\n \n Mane, S.; Singer, J.; Corin, A.; and Semprini, A.\n\n\n \n\n\n\n Case reports in dermatological medicine, 2018. 2018.\n Publisher: Hindawi\n\n\n\n
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@article{mane_successful_2018,\n\ttitle = {Successful {Treatment} of {Actinic} {Keratosis} with {Kanuka} {Honey}},\n\tvolume = {2018},\n\tissn = {2090-6463},\n\tjournal = {Case reports in dermatological medicine},\n\tauthor = {Mane, Saras and Singer, Joseph and Corin, Andrew and Semprini, Alex},\n\tyear = {2018},\n\tnote = {Publisher: Hindawi},\n}\n\n
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\n \n\n \n \n \n \n \n Protocol for a randomised controlled trial of 90% kanuka honey versus 5% aciclovir for the treatment of herpes simplex labialis in the community setting.\n \n \n \n\n\n \n Semprini, A.; Singer, J.; Shortt, N.; Braithwaite, I.; and Beasley, R.\n\n\n \n\n\n\n BMJ Open, 7: e017766. 2017.\n \n\n\n\n
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@article{semprini_protocol_2017,\n\ttitle = {Protocol for a randomised controlled trial of 90\\% kanuka honey versus 5\\% aciclovir for the treatment of herpes simplex labialis in the community setting},\n\tvolume = {7},\n\tdoi = {10.1136/bmjopen-2017-017766},\n\tjournal = {BMJ Open},\n\tauthor = {Semprini, Alex and Singer, Joseph and Shortt, Nick and Braithwaite, Irene and Beasley, Richard},\n\tyear = {2017},\n\tpages = {e017766},\n}\n\n
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\n \n\n \n \n \n \n \n Randomised controlled trial of topical kanuka honey for the treatment of acne.\n \n \n \n\n\n \n Semprini, A.; Braithwaite, I.; Corin, A.; Sheahan, D.; Tofield, C.; Helm, C.; Montgomery, B.; Fingleton, J.; Weatherall, M.; and Beasley, R.\n\n\n \n\n\n\n BMJ open, 6: e009448. 2016.\n \n\n\n\n
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@article{semprini_randomised_2016,\n\ttitle = {Randomised controlled trial of topical kanuka honey for the treatment of acne},\n\tvolume = {6},\n\tdoi = {10.1136/bmjopen-2015-009448},\n\tjournal = {BMJ open},\n\tauthor = {Semprini, Alex and Braithwaite, Irene and Corin, Andrew and Sheahan, Davitt and Tofield, Christopher and Helm, Colin and Montgomery, Barney and Fingleton, James and Weatherall, Mark and Beasley, Richard},\n\tyear = {2016},\n\tpages = {e009448},\n}\n\n
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\n  \n 2015\n \n \n (4)\n \n \n
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\n \n\n \n \n \n \n \n A topical Kanuka honey formulation is an effective treatment for rosacea.\n \n \n \n\n\n \n Holt, S; Beasley, R.; Weatherall, M.; Braithwaite, I.; Holliday, M.; Montgomery, B; Corin, A; Helm, C; Sheahan, D.; and Tofield, C.\n\n\n \n\n\n\n Australasian Journal of Dermatology, 56: A5–A6. 2015.\n \n\n\n\n
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@article{holt_topical_2015,\n\ttitle = {A topical {Kanuka} honey formulation is an effective treatment for rosacea},\n\tvolume = {56},\n\tjournal = {Australasian Journal of Dermatology},\n\tauthor = {Holt, S and Beasley, Richard and Weatherall, Mark and Braithwaite, Irene and Holliday, Mark and Montgomery, B and Corin, A and Helm, C and Sheahan, Davitt and Tofield, Christopher},\n\tyear = {2015},\n\tpages = {A5--A6},\n}\n\n
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\n \n\n \n \n \n \n \n Randomised controlled trial of topical kanuka honey for the treatment of rosacea.\n \n \n \n\n\n \n Braithwaite, I.; Hunt, A.; Riley, J.; Fingleton, J.; Kocks, J.; Corin, A.; Helm, C.; Sheahan, D.; Tofield, C.; Montgomery, B.; Holliday, M.; Weatherall, M.; and Beasley, R.\n\n\n \n\n\n\n BMJ open, 5: e007651. 2015.\n \n\n\n\n
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@article{braithwaite_randomised_2015,\n\ttitle = {Randomised controlled trial of topical kanuka honey for the treatment of rosacea},\n\tvolume = {5},\n\tdoi = {10.1136/bmjopen-2015-007651},\n\tjournal = {BMJ open},\n\tauthor = {Braithwaite, Irene and Hunt, Anna and Riley, Judith and Fingleton, James and Kocks, Janwillem and Corin, Andrew and Helm, Colin and Sheahan, Davitt and Tofield, Christopher and Montgomery, Barney and Holliday, Mark and Weatherall, Mark and Beasley, Richard},\n\tyear = {2015},\n\tpages = {e007651},\n}\n\n
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\n \n\n \n \n \n \n \n A single‐blind randomised controlled trial of topical kanuka honey for the treatment of nappy rash.\n \n \n \n\n\n \n Semprini, A.; Fingleton, J.; Hunt, A.; Riley, J.; Corin, A.; and Tofield, C.\n\n\n \n\n\n\n Focus on Alternative and Complementary Therapies, 20(3-4): 187–188. 2015.\n Number: 3-4 Publisher: Wiley Online Library\n\n\n\n
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@article{semprini_singleblind_2015,\n\ttitle = {A single‐blind randomised controlled trial of topical kanuka honey for the treatment of nappy rash},\n\tvolume = {20},\n\tissn = {1465-3753},\n\tnumber = {3-4},\n\tjournal = {Focus on Alternative and Complementary Therapies},\n\tauthor = {Semprini, Alex and Fingleton, James and Hunt, Anna and Riley, Judith and Corin, Andrew and Tofield, Christopher},\n\tyear = {2015},\n\tnote = {Number: 3-4\nPublisher: Wiley Online Library},\n\tpages = {187--188},\n}\n\n
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\n \n\n \n \n \n \n \n A single-blind randomised controlled trial of a topical kanuka honey formulation for the treatment of acne.\n \n \n \n\n\n \n Holt, S; Beasley, R.; Weatherall, M.; Braithwaite, I.; Holliday, M.; Montgomery, B; Corin, A; Helm, C; Sheahan, D.; and Tofield, C.\n\n\n \n\n\n\n Australasian Journal of Dermatology, 56: A5–A5. 2015.\n \n\n\n\n
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@article{holt_single-blind_2015,\n\ttitle = {A single-blind randomised controlled trial of a topical kanuka honey formulation for the treatment of acne},\n\tvolume = {56},\n\tjournal = {Australasian Journal of Dermatology},\n\tauthor = {Holt, S and Beasley, Richard and Weatherall, Mark and Braithwaite, Irene and Holliday, Mark and Montgomery, B and Corin, A and Helm, C and Sheahan, Davitt and Tofield, Christopher},\n\tyear = {2015},\n\tpages = {A5--A5},\n}\n\n
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\n  \n 2014\n \n \n (4)\n \n \n
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\n \n\n \n \n \n \n \n A randomised controlled trial of topical Kanuka honey for the treatment of eczema.\n \n \n \n\n\n \n Fingleton, J.; Helm, C.; Tofield, C.; Weatherall, M.; and Beasley, R.\n\n\n \n\n\n\n JRSM Open, 5. 2014.\n \n\n\n\n
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@article{fingleton_randomised_2014,\n\ttitle = {A randomised controlled trial of topical {Kanuka} honey for the treatment of eczema},\n\tvolume = {5},\n\tdoi = {10.1177/2042533313509263},\n\tjournal = {JRSM Open},\n\tauthor = {Fingleton, James and Helm, Colin and Tofield, Christopher and Weatherall, Mark and Beasley, Richard},\n\tyear = {2014},\n\tkeywords = {complementaryTherapy},\n}\n\n
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\n \n\n \n \n \n \n \n Topical kanuka honey for the treatment of nappy rash.\n \n \n \n\n\n \n Fingleton, J.; Tofield, C.; Helm, C.; Corin, A.; Weatherall, M.; and Beasley, R.\n\n\n \n\n\n\n Focus on Alternative and Complementary Therapies, 19. 2014.\n \n\n\n\n
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@article{fingleton_topical_2014,\n\ttitle = {Topical kanuka honey for the treatment of nappy rash},\n\tvolume = {19},\n\tdoi = {10.1111/fct.12078},\n\tjournal = {Focus on Alternative and Complementary Therapies},\n\tauthor = {Fingleton, James and Tofield, Christopher and Helm, Colin and Corin, Andrew and Weatherall, Mark and Beasley, Richard},\n\tyear = {2014},\n\tkeywords = {complementaryTherapy},\n}\n\n
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\n \n\n \n \n \n \n \n Randomised controlled trial of topical kanuka honey for the treatment of cold sores.\n \n \n \n\n\n \n Fingleton, J.; Corin, A.; Sheahan, D.; Cave, N.; Braithwaite, I.; Weatherall, M.; and Beasley, R.\n\n\n \n\n\n\n Advances in Integrative Medicine, doi:10.101. 2014.\n \n\n\n\n
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@article{fingleton_randomised_2014-1,\n\ttitle = {Randomised controlled trial of topical kanuka honey for the treatment of cold sores},\n\tvolume = {doi:10.101},\n\tdoi = {10.1016/j.aimed.2014.09.001},\n\tjournal = {Advances in Integrative Medicine},\n\tauthor = {Fingleton, James and Corin, Andrew and Sheahan, Davitt and Cave, Nicola and Braithwaite, Irene and Weatherall, Mark and Beasley, Richard},\n\tyear = {2014},\n}\n\n
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\n \n\n \n \n \n \n \n A randomised controlled trial of topical Kanuka honey for the treatment of psoriasis.\n \n \n \n\n\n \n Fingleton, J.; Sheahan, D.; Corin, A.; Weatherall, M.; and Beasley, R.\n\n\n \n\n\n\n JRSM Open, 5. 2014.\n \n\n\n\n
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@article{fingleton_randomised_2014-2,\n\ttitle = {A randomised controlled trial of topical {Kanuka} honey for the treatment of psoriasis},\n\tvolume = {5},\n\tdoi = {10.1177/2042533313518913},\n\tjournal = {JRSM Open},\n\tauthor = {Fingleton, James and Sheahan, Davitt and Corin, Andrew and Weatherall, Mark and Beasley, Richard},\n\tyear = {2014},\n}\n
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\n \n\n \n \n \n \n \n Topical kanuka honey for the treatment of rosacea.\n \n \n \n\n\n \n Fingleton, J.; Sheahan, D.; Cave, N.; Brinded, A.; Weatherall, M.; Perrin, K.; and Beasley, R.\n\n\n \n\n\n\n Focus on Alternative and Complementary Therapies, 18. 2013.\n \n\n\n\n
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@article{fingleton_topical_2013,\n\ttitle = {Topical kanuka honey for the treatment of rosacea},\n\tvolume = {18},\n\tdoi = {10.1111/fct.12057},\n\tjournal = {Focus on Alternative and Complementary Therapies},\n\tauthor = {Fingleton, James and Sheahan, Davitt and Cave, Nicola and Brinded, Alexander and Weatherall, Mark and Perrin, Kyle and Beasley, Richard},\n\tyear = {2013},\n}\n\n
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