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\n  \n 2021\n \n \n (2)\n \n \n
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\n \n\n \n \n \n \n \n \n Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke.\n \n \n \n \n\n\n \n Whitlock, R. P.; Belley-Cote, E. P.; Paparella, D.; Healey, J. S.; Brady, K.; Sharma, M.; Reents, W.; Budera, P.; Baddour, A. J.; Fila, P.; Devereaux, P.; Bogachev-Prokophiev, A.; Boening, A.; Teoh, K. H.; Tagarakis, G. I.; Slaughter, M. S.; Royse, A. G.; McGuinness, S.; Alings, M.; Punjabi, P. P.; Mazer, C. D.; Folkeringa, R. J.; Colli, A.; Avezum, Á.; Nakamya, J.; Balasubramanian, K.; Vincent, J.; Voisine, P.; Lamy, A.; Yusuf, S.; and Connolly, S. J.\n\n\n \n\n\n\n New England Journal of Medicine,NEJMoa2101897. May 2021.\n \n\n\n\n
\n\n\n\n \n \n \"LeftPaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n  \n \n 2 downloads\n \n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{whitlock_left_2021,\n\ttitle = {Left {Atrial} {Appendage} {Occlusion} during {Cardiac} {Surgery} to {Prevent} {Stroke}},\n\tissn = {0028-4793, 1533-4406},\n\turl = {http://www.nejm.org/doi/10.1056/NEJMoa2101897},\n\tdoi = {10.1056/NEJMoa2101897},\n\tlanguage = {en},\n\turldate = {2021-05-16},\n\tjournal = {New England Journal of Medicine},\n\tauthor = {Whitlock, Richard P. and Belley-Cote, Emilie P. and Paparella, Domenico and Healey, Jeff S. and Brady, Katheryn and Sharma, Mukul and Reents, Wilko and Budera, Petr and Baddour, Andony J. and Fila, Petr and Devereaux, P.J. and Bogachev-Prokophiev, Alexander and Boening, Andreas and Teoh, Kevin H.T. and Tagarakis, Georgios I. and Slaughter, Mark S. and Royse, Alistair G. and McGuinness, Shay and Alings, Marco and Punjabi, Prakash P. and Mazer, C. David and Folkeringa, Richard J. and Colli, Andrea and Avezum, Álvaro and Nakamya, Juliet and Balasubramanian, Kumar and Vincent, Jessica and Voisine, Pierre and Lamy, Andre and Yusuf, Salim and Connolly, Stuart J.},\n\tmonth = may,\n\tyear = {2021},\n\tpages = {NEJMoa2101897},\n}\n\n
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\n \n\n \n \n \n \n \n \n A Multicenter, Open-Label, Randomized Controlled Trial of a Conservative Fluid Management Strategy Compared With Usual Care in Participants After Cardiac Surgery: The Fluids After Bypass Study*.\n \n \n \n \n\n\n \n Parke, R. L.; Gilder, E.; Gillham, M. J.; Walker, L. J. C.; Bailey, M. J.; and McGuinness, S. P.\n\n\n \n\n\n\n Critical Care Medicine, 49(3): 449–461. March 2021.\n \n\n\n\n
\n\n\n\n \n \n \"APaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{parke_multicenter_2021,\n\ttitle = {A {Multicenter}, {Open}-{Label}, {Randomized} {Controlled} {Trial} of a {Conservative} {Fluid} {Management} {Strategy} {Compared} {With} {Usual} {Care} in {Participants} {After} {Cardiac} {Surgery}: {The} {Fluids} {After} {Bypass} {Study}*},\n\tvolume = {49},\n\tissn = {0090-3493},\n\tshorttitle = {A {Multicenter}, {Open}-{Label}, {Randomized} {Controlled} {Trial} of a {Conservative} {Fluid} {Management} {Strategy} {Compared} {With} {Usual} {Care} in {Participants} {After} {Cardiac} {Surgery}},\n\turl = {https://journals.lww.com/10.1097/CCM.0000000000004883},\n\tdoi = {10.1097/CCM.0000000000004883},\n\tlanguage = {en},\n\tnumber = {3},\n\turldate = {2021-04-30},\n\tjournal = {Critical Care Medicine},\n\tauthor = {Parke, Rachael L. and Gilder, Eileen and Gillham, Michael J. and Walker, Laurence J. C. and Bailey, Michael J. and McGuinness, Shay P.},\n\tmonth = mar,\n\tyear = {2021},\n\tpages = {449--461},\n}\n\n
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\n  \n 2020\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n \n Avoidance of Routine Endotracheal Suction in Subjects Ventilated for ≤ 12 h Following Elective Cardiac Surgery.\n \n \n \n \n\n\n \n Gilder, E.; McGuinness, S. P; Cavadino, A.; Jull, A.; and Parke, R. L\n\n\n \n\n\n\n Respiratory Care,respcare.07821. August 2020.\n \n\n\n\n
\n\n\n\n \n \n \"AvoidancePaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{gilder_avoidance_2020,\n\ttitle = {Avoidance of {Routine} {Endotracheal} {Suction} in {Subjects} {Ventilated} for ≤ 12 h {Following} {Elective} {Cardiac} {Surgery}},\n\tissn = {0020-1324, 1943-3654},\n\turl = {http://rc.rcjournal.com/lookup/doi/10.4187/respcare.07821},\n\tdoi = {10.4187/respcare.07821},\n\tlanguage = {en},\n\turldate = {2021-05-12},\n\tjournal = {Respiratory Care},\n\tauthor = {Gilder, Eileen and McGuinness, Shay P and Cavadino, Alana and Jull, Andrew and Parke, Rachael L},\n\tmonth = aug,\n\tyear = {2020},\n\tpages = {respcare.07821},\n}\n\n
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\n  \n 2018\n \n \n (4)\n \n \n
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\n \n\n \n \n \n \n \n Transfusion Requirements in Cardiac Surgery III (TRICS III): study design of a randomized controlled trial.\n \n \n \n\n\n \n Shehata, N.; Whitlock, R.; Fergusson, D. A; Thorpe, K. E; MacAdams, C.; Grocott, H. P; Rubens, F.; Fremes, S.; Lellouche, F.; and Bagshaw, S.\n\n\n \n\n\n\n Journal of cardiothoracic and vascular anesthesia, 32(1): 121–129. 2018.\n Number: 1 Publisher: Elsevier\n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{shehata_transfusion_2018,\n\ttitle = {Transfusion {Requirements} in {Cardiac} {Surgery} {III} ({TRICS} {III}): study design of a randomized controlled trial},\n\tvolume = {32},\n\tissn = {1053-0770},\n\tnumber = {1},\n\tjournal = {Journal of cardiothoracic and vascular anesthesia},\n\tauthor = {Shehata, Nadine and Whitlock, Richard and Fergusson, Dean A and Thorpe, Kevin E and MacAdams, Charlie and Grocott, Hilary P and Rubens, Fraser and Fremes, Stephen and Lellouche, Francois and Bagshaw, Sean},\n\tyear = {2018},\n\tnote = {Number: 1\nPublisher: Elsevier},\n\tpages = {121--129},\n}\n\n
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\n \n\n \n \n \n \n \n Six-month outcomes after restrictive or liberal transfusion for cardiac surgery.\n \n \n \n\n\n \n Mazer, C D.; Whitlock, R. P; Fergusson, D. A; Belley-Cote, E.; Connolly, K.; Khanykin, B.; Gregory, A. J; de Médicis, É.; Carrier, F. M; and McGuinness, S.\n\n\n \n\n\n\n New England Journal of Medicine, 379(13): 1224–1233. 2018.\n Number: 13 Publisher: Mass Medical Soc\n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{mazer_six-month_2018,\n\ttitle = {Six-month outcomes after restrictive or liberal transfusion for cardiac surgery},\n\tvolume = {379},\n\tissn = {0028-4793},\n\tnumber = {13},\n\tjournal = {New England Journal of Medicine},\n\tauthor = {Mazer, C David and Whitlock, Richard P and Fergusson, Dean A and Belley-Cote, Emilie and Connolly, Katherine and Khanykin, Boris and Gregory, Alexander J and de Médicis, Étienne and Carrier, François M and McGuinness, Shay},\n\tyear = {2018},\n\tnote = {Number: 13\nPublisher: Mass Medical Soc},\n\tpages = {1224--1233},\n}\n\n
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\n \n\n \n \n \n \n \n Fluid resuscitation associated with elevated angiopoietin-2 and length of mechanical ventilation after cardiac surgery.\n \n \n \n\n\n \n Parke, R.; Bihari, S.; Dixon, D.; Gilder, E.; Cavallaro, E.; McGuinness, S.; and Bersten, A. D\n\n\n \n\n\n\n Critical Care and Resuscitation, 20(3): 198. 2018.\n Number: 3 Publisher: The Australasian Medical Publishing Company\n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{parke_fluid_2018,\n\ttitle = {Fluid resuscitation associated with elevated angiopoietin-2 and length of mechanical ventilation after cardiac surgery},\n\tvolume = {20},\n\tnumber = {3},\n\tjournal = {Critical Care and Resuscitation},\n\tauthor = {Parke, Rachael and Bihari, Shailesh and Dixon, Dani-Louise and Gilder, Eileen and Cavallaro, Elena and McGuinness, Shay and Bersten, Andrew D},\n\tyear = {2018},\n\tnote = {Number: 3\nPublisher: The Australasian Medical Publishing Company},\n\tpages = {198},\n}\n\n
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\n \n\n \n \n \n \n \n Design and statistical analysis plan for a trial comparing a conservative fluid management strategy with usual care in patients after cardiac surgery: the FAB study.\n \n \n \n\n\n \n Parke, R.; Gilder, E.; Gillham, M.; Walker, L.; Bailey, M.; and McGuinness, S.\n\n\n \n\n\n\n Critical Care and Resuscitation, 20(3): 190. 2018.\n Number: 3 Publisher: The Australasian Medical Publishing Company\n\n\n\n
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@article{parke_design_2018,\n\ttitle = {Design and statistical analysis plan for a trial comparing a conservative fluid management strategy with usual care in patients after cardiac surgery: the {FAB} study},\n\tvolume = {20},\n\tnumber = {3},\n\tjournal = {Critical Care and Resuscitation},\n\tauthor = {Parke, Rachael and Gilder, Eileen and Gillham, Michael and Walker, Laurence and Bailey, Michael and McGuinness, Shay},\n\tyear = {2018},\n\tnote = {Number: 3\nPublisher: The Australasian Medical Publishing Company},\n\tpages = {190},\n}\n\n
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\n  \n 2017\n \n \n (3)\n \n \n
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\n \n\n \n \n \n \n \n Tranexamic acid in patients undergoing coronary-artery surgery.\n \n \n \n\n\n \n Myles, P. S; Smith, J. A; Forbes, A.; Silbert, B.; Jayarajah, M.; Painter, T.; Cooper, D J.; Marasco, S.; McNeil, J.; and Bussières, J. S\n\n\n \n\n\n\n New England Journal of Medicine, 376(2): 136–148. 2017.\n Number: 2 Publisher: Mass Medical Soc\n\n\n\n
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@article{myles_tranexamic_2017,\n\ttitle = {Tranexamic acid in patients undergoing coronary-artery surgery},\n\tvolume = {376},\n\tissn = {0028-4793},\n\tnumber = {2},\n\tjournal = {New England Journal of Medicine},\n\tauthor = {Myles, Paul S and Smith, Julian A and Forbes, Andrew and Silbert, Brendan and Jayarajah, Mohandas and Painter, Thomas and Cooper, D James and Marasco, Silvana and McNeil, John and Bussières, Jean S},\n\tyear = {2017},\n\tnote = {Number: 2\nPublisher: Mass Medical Soc},\n\tpages = {136--148},\n}\n\n
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\n \n\n \n \n \n \n \n Restrictive or liberal red-cell transfusion for cardiac surgery.\n \n \n \n\n\n \n Mazer, C D.; Whitlock, R. P; Fergusson, D. A; Hall, J.; Belley-Cote, E.; Connolly, K.; Khanykin, B.; Gregory, A. J; de Médicis, É.; and McGuinness, S.\n\n\n \n\n\n\n New England Journal of Medicine, 377(22): 2133–2144. 2017.\n Number: 22 Publisher: Mass Medical Soc\n\n\n\n
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@article{mazer_restrictive_2017,\n\ttitle = {Restrictive or liberal red-cell transfusion for cardiac surgery},\n\tvolume = {377},\n\tissn = {0028-4793},\n\tnumber = {22},\n\tjournal = {New England Journal of Medicine},\n\tauthor = {Mazer, C David and Whitlock, Richard P and Fergusson, Dean A and Hall, Judith and Belley-Cote, Emilie and Connolly, Katherine and Khanykin, Boris and Gregory, Alexander J and de Médicis, Étienne and McGuinness, Shay},\n\tyear = {2017},\n\tnote = {Number: 22\nPublisher: Mass Medical Soc},\n\tpages = {2133--2144},\n}\n\n
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\n \n\n \n \n \n \n \n Effect of 0.9% saline or Plasma-Lyte 148 as crystalloid fluid therapy in the intensive care unit on blood product use and postoperative bleeding after cardiac surgery.\n \n \n \n\n\n \n Reddy, S. K; Bailey, M. J; Beasley, R. W; Bellomo, R.; Mackle, D. M; Psirides, A. J; and Young, P. J\n\n\n \n\n\n\n Journal of cardiothoracic and vascular anesthesia, 31(5): 1630–1638. 2017.\n Number: 5 Publisher: Elsevier\n\n\n\n
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@article{reddy_effect_2017,\n\ttitle = {Effect of 0.9\\% saline or {Plasma}-{Lyte} 148 as crystalloid fluid therapy in the intensive care unit on blood product use and postoperative bleeding after cardiac surgery},\n\tvolume = {31},\n\tissn = {1053-0770},\n\tnumber = {5},\n\tjournal = {Journal of cardiothoracic and vascular anesthesia},\n\tauthor = {Reddy, Sumeet K and Bailey, Michael J and Beasley, Richard W and Bellomo, Rinaldo and Mackle, Diane M and Psirides, Alex J and Young, Paul J},\n\tyear = {2017},\n\tnote = {Number: 5\nPublisher: Elsevier},\n\tpages = {1630--1638},\n}\n\n
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\n \n\n \n \n \n \n \n A prospective study of the timing and accuracy of neutrophil gelatinase-associated lipocalin levels in predicting acute kidney injury in high-risk cardiac surgery patients.\n \n \n \n\n\n \n Fanning, N.; Galvin, S.; Parke, R.; Gilroy, J.; Bellomo, R.; and McGuinness, S.\n\n\n \n\n\n\n Journal of cardiothoracic and vascular anesthesia, 30(1): 76–81. 2016.\n Number: 1 Publisher: Elsevier\n\n\n\n
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@article{fanning_prospective_2016,\n\ttitle = {A prospective study of the timing and accuracy of neutrophil gelatinase-associated lipocalin levels in predicting acute kidney injury in high-risk cardiac surgery patients},\n\tvolume = {30},\n\tissn = {1053-0770},\n\tnumber = {1},\n\tjournal = {Journal of cardiothoracic and vascular anesthesia},\n\tauthor = {Fanning, Niall and Galvin, Sinead and Parke, Rachael and Gilroy, James and Bellomo, Rinaldo and McGuinness, Shay},\n\tyear = {2016},\n\tnote = {Number: 1\nPublisher: Elsevier},\n\tpages = {76--81},\n}\n\n
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\n  \n 2015\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n \n A Randomised feasibility study to assess a novel strategy to rationalise fluid in patients after cardiac surgery.\n \n \n \n \n\n\n \n Parke, R L; McGuinness, S P; Gilder, E; McCarthy, L W; and Cowdrey, K. L\n\n\n \n\n\n\n British Journal of Anaesthesia, 115(1): 45–52. 2015.\n Number: 1\n\n\n\n
\n\n\n\n \n \n \"APaper\n  \n \n\n \n \n doi\n  \n \n\n \n link\n  \n \n\n bibtex\n \n\n \n  \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n
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@article{parke_randomised_2015,\n\ttitle = {A {Randomised} feasibility study to assess a novel strategy to rationalise fluid in patients after cardiac surgery},\n\tvolume = {115},\n\tissn = {0007-0912},\n\turl = {http://www.sciencedirect.com/science/article/pii/S0007091217312394},\n\tdoi = {https://doi.org/10.1093/bja/aev118},\n\tabstract = {Background After cardiac surgery, patients receive large amounts of fluid in the Intensive Care Unit (ICU). We plan to conduct a multi-centre randomised controlled trial, of a conservative fluid regime, in patients after cardiac surgery, and have reported results of a feasibility study that evaluated efficacy and safety of the proposed regime. Methods After ethical approval, a single-centre, prospectively randomised interventional study was undertaken. Participants were randomised to either usual care, or to a protocolised algorithm, utilising stroke volume variation, to guide fluid administration to patients who were deemed to have inadequate cardiac output and were likely to be volume responsive. The study protocol lasted from ICU admission to de-sedation or 24 h, whichever occurred first. Results We randomised 144 subjects over 9 months. Less bolus fluid and less total overall fluid volume was administered in the intervention group (median (IQR) 1620 ml (500–3410) and 2525 ml (1440–5250; P{\\textbackslash}textless0.001), compared with the usual care group (2050 ml (910–4280) and 2980 ml (2070–6580; P=0.001), from ICU admission to extubation. There was no significant difference in incidence of acute kidney injury or the average amount of fluid administered to the usual care group at the beginning compared with the end of the study. Conclusion It is both possible and safe to achieve a significant reduction in the amount of fluid administered to patients, allocated to a conservative fluid protocol. These results suggest that a planned multi-centre study is both justified and feasible. Clinical trial registration Australia New Zealand Clinical Trials Registry www.anzctr.org.au (ACTRN12612000754842).},\n\tnumber = {1},\n\tjournal = {British Journal of Anaesthesia},\n\tauthor = {Parke, R L and McGuinness, S P and Gilder, E and McCarthy, L W and Cowdrey, K.-A. L},\n\tyear = {2015},\n\tnote = {Number: 1},\n\tkeywords = {acute kidney injury, cardiac output, cardiac surgery, haemodynamics, intensive care units},\n\tpages = {45--52},\n}\n
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\n Background After cardiac surgery, patients receive large amounts of fluid in the Intensive Care Unit (ICU). We plan to conduct a multi-centre randomised controlled trial, of a conservative fluid regime, in patients after cardiac surgery, and have reported results of a feasibility study that evaluated efficacy and safety of the proposed regime. Methods After ethical approval, a single-centre, prospectively randomised interventional study was undertaken. Participants were randomised to either usual care, or to a protocolised algorithm, utilising stroke volume variation, to guide fluid administration to patients who were deemed to have inadequate cardiac output and were likely to be volume responsive. The study protocol lasted from ICU admission to de-sedation or 24 h, whichever occurred first. Results We randomised 144 subjects over 9 months. Less bolus fluid and less total overall fluid volume was administered in the intervention group (median (IQR) 1620 ml (500–3410) and 2525 ml (1440–5250; P\\textless0.001), compared with the usual care group (2050 ml (910–4280) and 2980 ml (2070–6580; P=0.001), from ICU admission to extubation. There was no significant difference in incidence of acute kidney injury or the average amount of fluid administered to the usual care group at the beginning compared with the end of the study. Conclusion It is both possible and safe to achieve a significant reduction in the amount of fluid administered to patients, allocated to a conservative fluid protocol. These results suggest that a planned multi-centre study is both justified and feasible. Clinical trial registration Australia New Zealand Clinical Trials Registry www.anzctr.org.au (ACTRN12612000754842).\n
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\n  \n 2013\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n A Randomised Controlled Double-Blind Study of Remote Ischaemic Preconditioning in High-Risk Cardiac Surgery.\n \n \n \n\n\n \n Young, P.; Mahon, B.; Dalley, P.; Garden, A.; Horrocks, C.; Flamme, A.; Miller, J. H.; Pilcher, J.; Weatherall, M.; Williams, J.; Young, W.; and Beasley, R.\n\n\n \n\n\n\n Heart, Lung and Circulation, 22: 474. 2013.\n \n\n\n\n
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@article{young_randomised_2013,\n\ttitle = {A {Randomised} {Controlled} {Double}-{Blind} {Study} of {Remote} {Ischaemic} {Preconditioning} in {High}-{Risk} {Cardiac} {Surgery}},\n\tvolume = {22},\n\tdoi = {10.1016/j.hlc.2013.03.043},\n\tjournal = {Heart, Lung and Circulation},\n\tauthor = {Young, Paul and Mahon, Barry and Dalley, Paul and Garden, Alexander and Horrocks, Christopher and Flamme, Anne and Miller, John Holmes and Pilcher, Janine and Weatherall, Mark and Williams, Jenni and Young, William and Beasley, Richard},\n\tyear = {2013},\n\tpages = {474},\n}\n\n
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\n  \n 2012\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n Remote ischaemic preconditioning does not alter perioperative cytokine production in high-risk cardiac surgery.\n \n \n \n\n\n \n Williams, J.; Young, P.; Pilcher, J.; Weatherall, M.; Miller, J. H.; Beasley, R.; and Flamme, A.\n\n\n \n\n\n\n Heart Asia, 4: 97–101. 2012.\n \n\n\n\n
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@article{williams_remote_2012,\n\ttitle = {Remote ischaemic preconditioning does not alter perioperative cytokine production in high-risk cardiac surgery},\n\tvolume = {4},\n\tdoi = {10.1136/heartasia-2012-010122},\n\tjournal = {Heart Asia},\n\tauthor = {Williams, Jenni and Young, Paul and Pilcher, Janine and Weatherall, Mark and Miller, John Holmes and Beasley, Richard and Flamme, Anne},\n\tyear = {2012},\n\tpages = {97--101},\n}\n\n
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