var bibbase_data = {"data":"<img src=\"//bibbase.org/img/ajax-loader.gif\" id=\"spinner\"\n  style=\"display: none;\" alt=\"Loading..\" />\n\n<div id=\"bibbase\">\n\n  <script type=\"text/javascript\">\n    var bibbase = {\n      params: {\"bib\":\"https://api.zotero.org/users/6607533/collections/VKGURBGN/items?key=AfCmNvQz44bDQHYTFDzNWXL7&format=bibtex&limit=100\",\"jsonp\":\"1\",\"host\":\"bibbase.org\"},\n      data: [{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Current role of high dose vitamin C in sepsis management: A concise review\",\"volume\":\"11\",\"issn\":\"2220-3141\",\"shorttitle\":\"Current role of high dose vitamin C in sepsis management\",\"url\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693906/\",\"doi\":\"10.5492/wjccm.v11.i6.349\",\"abstract\":\"Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality. In addition to aggressive fluid resuscitation and antibiotic therapy, several other drugs have been tried as adjuvant therapies to reduce the inflammatory response and improve outcomes. Vitamin C has been shown to have several biological actions, including anti-inflammatory and immunomodulatory effects, which may prove beneficial in sepsis management. Initial trials showed improved patient outcomes when high dose vitamin C was used in combination with thiamine and hydrocortisone. These results, along with relative safety of high-dose (supra-physiological) vitamin C, encouraged physicians across the globe to add vitamin C as an adjuvant therapy in the management of sepsis. However, subsequent large-scale randomised control trials could not replicate these results, leaving the world divided regarding the role of vitamin C in sepsis management. Here, we discuss the rationale, safety profile, and the current clinical evidence for the use of high-dose vitamin C in the management of sepsis and septic shock.\",\"number\":\"6\",\"urldate\":\"2024-03-07\",\"journal\":\"World Journal of Critical Care Medicine\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Juneja\"],\"firstnames\":[\"Deven\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Nasa\"],\"firstnames\":[\"Prashant\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Jain\"],\"firstnames\":[\"Ravi\"],\"suffixes\":[]}],\"month\":\"November\",\"year\":\"2022\",\"pmid\":\"36439321\",\"pmcid\":\"PMC9693906\",\"pages\":\"349–363\",\"bibtex\":\"@article{juneja_current_2022,\\n\\ttitle = {Current role of high dose vitamin {C} in sepsis management: {A} concise review},\\n\\tvolume = {11},\\n\\tissn = {2220-3141},\\n\\tshorttitle = {Current role of high dose vitamin {C} in sepsis management},\\n\\turl = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693906/},\\n\\tdoi = {10.5492/wjccm.v11.i6.349},\\n\\tabstract = {Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality. In addition to aggressive fluid resuscitation and antibiotic therapy, several other drugs have been tried as adjuvant therapies to reduce the inflammatory response and improve outcomes. Vitamin C has been shown to have several biological actions, including anti-inflammatory and immunomodulatory effects, which may prove beneficial in sepsis management. Initial trials showed improved patient outcomes when high dose vitamin C was used in combination with thiamine and hydrocortisone. These results, along with relative safety of high-dose (supra-physiological) vitamin C, encouraged physicians across the globe to add vitamin C as an adjuvant therapy in the management of sepsis. However, subsequent large-scale randomised control trials could not replicate these results, leaving the world divided regarding the role of vitamin C in sepsis management. Here, we discuss the rationale, safety profile, and the current clinical evidence for the use of high-dose vitamin C in the management of sepsis and septic shock.},\\n\\tnumber = {6},\\n\\turldate = {2024-03-07},\\n\\tjournal = {World Journal of Critical Care Medicine},\\n\\tauthor = {Juneja, Deven and Nasa, Prashant and Jain, Ravi},\\n\\tmonth = nov,\\n\\tyear = {2022},\\n\\tpmid = {36439321},\\n\\tpmcid = {PMC9693906},\\n\\tpages = {349--363},\\n}\\n\\n\",\"author_short\":[\"Juneja, D.\",\"Nasa, P.\",\"Jain, R.\"],\"key\":\"juneja_current_2022\",\"id\":\"juneja_current_2022\",\"bibbaseid\":\"juneja-nasa-jain-currentroleofhighdosevitamincinsepsismanagementaconcisereview-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693906/\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study\",\"volume\":\"12\",\"issn\":\"2044-6055, 2044-6055\",\"shorttitle\":\"Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens\",\"url\":\"https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537\",\"doi\":\"10.1136/bmjopen-2020-048537\",\"abstract\":\"Objectives As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens. Setting A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment. Participants Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings. Results Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it. Conclusions Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation. Trial registration number ACTRN12615000999538.\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2022-03-27\",\"journal\":\"BMJ Open\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Foster\"],\"firstnames\":[\"Juliet\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Braithwaite\"],\"firstnames\":[\"Irene\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harrison\"],\"firstnames\":[\"Tim\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Holliday\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reddel\"],\"firstnames\":[\"Helen\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2022\",\"pages\":\"e048537\",\"bibtex\":\"@article{foster_perspectives_2022,\\n\\ttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study},\\n\\tvolume = {12},\\n\\tissn = {2044-6055, 2044-6055},\\n\\tshorttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens},\\n\\turl = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537},\\n\\tdoi = {10.1136/bmjopen-2020-048537},\\n\\tabstract = {Objectives\\n              As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens.\\n            \\n            \\n              Setting\\n              A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment.\\n            \\n            \\n              Participants\\n              Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings.\\n            \\n            \\n              Results\\n              Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it.\\n            \\n            \\n              Conclusions\\n              Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation.\\n            \\n            \\n              Trial registration number\\n              ACTRN12615000999538.},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2022-03-27},\\n\\tjournal = {BMJ Open},\\n\\tauthor = {Foster, Juliet and Beasley, Richard and Braithwaite, Irene and Harrison, Tim and Holliday, Mark and Pavord, Ian and Reddel, Helen},\\n\\tmonth = jan,\\n\\tyear = {2022},\\n\\tpages = {e048537},\\n}\\n\\n\",\"author_short\":[\"Foster, J.\",\"Beasley, R.\",\"Braithwaite, I.\",\"Harrison, T.\",\"Holliday, M.\",\"Pavord, I.\",\"Reddel, H.\"],\"key\":\"foster_perspectives_2022\",\"id\":\"foster_perspectives_2022\",\"bibbaseid\":\"foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype Oxford Asthma Attack Risk Scale (ORACLE)\",\"volume\":\"8\",\"issn\":\"2312-0541\",\"url\":\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021\",\"doi\":\"10.1183/23120541.00570-2021\",\"language\":\"en\",\"number\":\"1\",\"urldate\":\"2022-03-27\",\"journal\":\"ERJ Open Research\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Couillard\"],\"firstnames\":[\"Simon\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Do\"],\"firstnames\":[\"William\",\"Il\",\"Hoon\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hinks\"],\"firstnames\":[\"Timothy\",\"S.C.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pavord\"],\"firstnames\":[\"Ian\",\"D.\"],\"suffixes\":[]}],\"month\":\"January\",\"year\":\"2022\",\"pages\":\"00570–2021\",\"bibtex\":\"@article{couillard_predicting_2022,\\n\\ttitle = {Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype {Oxford} {Asthma} {Attack} {Risk} {Scale} ({ORACLE})},\\n\\tvolume = {8},\\n\\tissn = {2312-0541},\\n\\turl = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021},\\n\\tdoi = {10.1183/23120541.00570-2021},\\n\\tlanguage = {en},\\n\\tnumber = {1},\\n\\turldate = {2022-03-27},\\n\\tjournal = {ERJ Open Research},\\n\\tauthor = {Couillard, Simon and Do, William Il Hoon and Beasley, Richard and Hinks, Timothy S.C. and Pavord, Ian D.},\\n\\tmonth = jan,\\n\\tyear = {2022},\\n\\tpages = {00570--2021},\\n}\\n\\n\",\"author_short\":[\"Couillard, S.\",\"Do, W. I. H.\",\"Beasley, R.\",\"Hinks, T. S.\",\"Pavord, I. D.\"],\"key\":\"couillard_predicting_2022\",\"id\":\"couillard_predicting_2022\",\"bibbaseid\":\"couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’\",\"volume\":\"27\",\"issn\":\"1323-7799, 1440-1843\",\"shorttitle\":\"Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults\",\"url\":\"https://onlinelibrary.wiley.com/doi/10.1111/resp.14218\",\"doi\":\"10.1111/resp.14218\",\"language\":\"en\",\"number\":\"4\",\"urldate\":\"2022-03-27\",\"journal\":\"Respirology\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Barnett\"],\"firstnames\":[\"Adrian\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Buchan\"],\"firstnames\":[\"Catherine\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chien\"],\"firstnames\":[\"Jimmy\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Farah\"],\"firstnames\":[\"Claude\",\"S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"King\"],\"firstnames\":[\"Gregory\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"McDonald\"],\"firstnames\":[\"Christine\",\"F.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Miller\"],\"firstnames\":[\"Belinda\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Munsif\"],\"firstnames\":[\"Maitri\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Psirides\"],\"firstnames\":[\"Alex\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Reid\"],\"firstnames\":[\"Lynette\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Roberts\"],\"firstnames\":[\"Mary\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Smallwood\"],\"firstnames\":[\"Natasha\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Smith\"],\"firstnames\":[\"Sheree\"],\"suffixes\":[]}],\"month\":\"April\",\"year\":\"2022\",\"pages\":\"262–276\",\"bibtex\":\"@article{barnett_thoracic_2022,\\n\\ttitle = {Thoracic {Society} of {Australia} and {New} {Zealand} {Position} {Statement} on {Acute} {Oxygen} {Use} in {Adults}: ‘{Swimming} between the flags’},\\n\\tvolume = {27},\\n\\tissn = {1323-7799, 1440-1843},\\n\\tshorttitle = {Thoracic {Society} of {Australia} and {New} {Zealand} {Position} {Statement} on {Acute} {Oxygen} {Use} in {Adults}},\\n\\turl = {https://onlinelibrary.wiley.com/doi/10.1111/resp.14218},\\n\\tdoi = {10.1111/resp.14218},\\n\\tlanguage = {en},\\n\\tnumber = {4},\\n\\turldate = {2022-03-27},\\n\\tjournal = {Respirology},\\n\\tauthor = {Barnett, Adrian and Beasley, Richard and Buchan, Catherine and Chien, Jimmy and Farah, Claude S. and King, Gregory and McDonald, Christine F. and Miller, Belinda and Munsif, Maitri and Psirides, Alex and Reid, Lynette and Roberts, Mary and Smallwood, Natasha and Smith, Sheree},\\n\\tmonth = apr,\\n\\tyear = {2022},\\n\\tpages = {262--276},\\n}\\n\\n\",\"author_short\":[\"Barnett, A.\",\"Beasley, R.\",\"Buchan, C.\",\"Chien, J.\",\"Farah, C. S.\",\"King, G.\",\"McDonald, C. F.\",\"Miller, B.\",\"Munsif, M.\",\"Psirides, A.\",\"Reid, L.\",\"Roberts, M.\",\"Smallwood, N.\",\"Smith, S.\"],\"key\":\"barnett_thoracic_2022\",\"id\":\"barnett_thoracic_2022\",\"bibbaseid\":\"barnett-beasley-buchan-chien-farah-king-mcdonald-miller-etal-thoracicsocietyofaustraliaandnewzealandpositionstatementonacuteoxygenuseinadultsswimmingbetweentheflags-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://onlinelibrary.wiley.com/doi/10.1111/resp.14218\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma: A Systematic Review and Meta-analysis\",\"volume\":\"5\",\"issn\":\"2574-3805\",\"shorttitle\":\"Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma\",\"url\":\"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512\",\"doi\":\"10.1001/jamanetworkopen.2022.0615\",\"language\":\"en\",\"number\":\"3\",\"urldate\":\"2022-03-04\",\"journal\":\"JAMA Network Open\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Harrison\"],\"firstnames\":[\"Tim\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Peterson\"],\"firstnames\":[\"Stefan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gustafson\"],\"firstnames\":[\"Per\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Hamblin\"],\"firstnames\":[\"Angus\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bengtsson\"],\"firstnames\":[\"Thomas\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Fagerås\"],\"firstnames\":[\"Malin\"],\"suffixes\":[]}],\"month\":\"March\",\"year\":\"2022\",\"pages\":\"e220615\",\"bibtex\":\"@article{beasley_evaluation_2022,\\n\\ttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}: {A} {Systematic} {Review} and {Meta}-analysis},\\n\\tvolume = {5},\\n\\tissn = {2574-3805},\\n\\tshorttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}},\\n\\turl = {https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512},\\n\\tdoi = {10.1001/jamanetworkopen.2022.0615},\\n\\tlanguage = {en},\\n\\tnumber = {3},\\n\\turldate = {2022-03-04},\\n\\tjournal = {JAMA Network Open},\\n\\tauthor = {Beasley, Richard and Harrison, Tim and Peterson, Stefan and Gustafson, Per and Hamblin, Angus and Bengtsson, Thomas and Fagerås, Malin},\\n\\tmonth = mar,\\n\\tyear = {2022},\\n\\tpages = {e220615},\\n}\\n\\n\",\"author_short\":[\"Beasley, R.\",\"Harrison, T.\",\"Peterson, S.\",\"Gustafson, P.\",\"Hamblin, A.\",\"Bengtsson, T.\",\"Fagerås, M.\"],\"key\":\"beasley_evaluation_2022\",\"id\":\"beasley_evaluation_2022\",\"bibbaseid\":\"beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"title\":\"Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: A randomised cross-over trial\",\"issn\":\"0903-1936, 1399-3003\",\"shorttitle\":\"Repeated dose budesonide/formoterol compared to salbutamol in adult asthma\",\"url\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021\",\"doi\":\"10.1183/13993003.02309-2021\",\"abstract\":\"Objective To determine the comparative bronchodilator, systemic beta 2 -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma. Methods This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg via MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg via nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation via Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV 1 after 180 min. Secondary outcomes included repeat measures of FEV 1 , serum potassium, heart rate, and adverse events Results Of 39 patients randomised, two withdrew due to adverse events (QT CF prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean ( sd ) change from baseline FEV 1 180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean ( sd ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV 1 from 30 to 240 min, but lesser FEV 1 at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events. Conclusion The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose −1 and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta 2 -agonist and cardiovascular effects and more adverse events.\",\"language\":\"en\",\"urldate\":\"2022-03-04\",\"journal\":\"European Respiratory Journal\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Kearns\"],\"firstnames\":[\"Nethmi\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bruce\"],\"firstnames\":[\"Pepa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Williams\"],\"firstnames\":[\"Mathew\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Doppen\"],\"firstnames\":[\"Marjan\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Black\"],\"firstnames\":[\"Melissa\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Weatherall\"],\"firstnames\":[\"Mark\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Beasley\"],\"firstnames\":[\"Richard\"],\"suffixes\":[]}],\"month\":\"February\",\"year\":\"2022\",\"pages\":\"2102309\",\"bibtex\":\"@article{kearns_repeated_2022,\\n\\ttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: {A} randomised cross-over trial},\\n\\tissn = {0903-1936, 1399-3003},\\n\\tshorttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma},\\n\\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021},\\n\\tdoi = {10.1183/13993003.02309-2021},\\n\\tabstract = {Objective\\n              \\n                To determine the comparative bronchodilator, systemic beta\\n                2\\n                -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma.\\n              \\n            \\n            \\n              Methods\\n              \\n                This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg\\n                via\\n                MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg\\n                via\\n                nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation\\n                via\\n                Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV\\n                1\\n                after 180 min. Secondary outcomes included repeat measures of FEV\\n                1\\n                , serum potassium, heart rate, and adverse events\\n              \\n            \\n            \\n              Results\\n              \\n                Of 39 patients randomised, two withdrew due to adverse events (QT\\n                CF\\n                prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean (\\n                sd\\n                ) change from baseline FEV\\n                1\\n                180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean (\\n                sd\\n                ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95\\\\% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV\\n                1\\n                from 30 to 240 min, but lesser FEV\\n                1\\n                at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events.\\n              \\n            \\n            \\n              Conclusion\\n              \\n                The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose\\n                −1\\n                and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta\\n                2\\n                -agonist and cardiovascular effects and more adverse events.},\\n\\tlanguage = {en},\\n\\turldate = {2022-03-04},\\n\\tjournal = {European Respiratory Journal},\\n\\tauthor = {Kearns, Nethmi and Bruce, Pepa and Williams, Mathew and Doppen, Marjan and Black, Melissa and Weatherall, Mark and Beasley, Richard},\\n\\tmonth = feb,\\n\\tyear = {2022},\\n\\tpages = {2102309},\\n}\\n\",\"author_short\":[\"Kearns, N.\",\"Bruce, P.\",\"Williams, M.\",\"Doppen, M.\",\"Black, M.\",\"Weatherall, M.\",\"Beasley, R.\"],\"key\":\"kearns_repeated_2022\",\"id\":\"kearns_repeated_2022\",\"bibbaseid\":\"kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022\",\"role\":\"author\",\"urls\":{\"Paper\":\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"}],\n      metadata: {\"authorlinks\":{}},\n      ownerID: undefined\n    };\n  </script>\n\n  <script type=\"text/javascript\">\n  var site$;\n  if (typeof $ != 'undefined') {\n    console.log('existing jquery: storing and then restoring');\n    site$ = $;\n    $ = null;\n  }\n  </script>\n\n  <script src=\"https://ajax.googleapis.com/ajax/libs/jquery/2.2.4/jquery.min.js\">\n  </script>\n  <script type=\"text/javascript\">\n  if (site$) {\n    console.log('existing jquery: avoiding conflict and restoring');\n    bb$ = $.noConflict(true);\n    $ = site$;\n  } else {\n    bb$ = $;\n  }\n  </script>\n\n  <script src=\"//bibbase.org/js/bibbase.min.js\"\n          type=\"text/javascript\">\n  </script>\n\n  <script type=\"text/javascript\"\n          src=\"https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.1/MathJax.js?config=TeX-AMS-MML_HTMLorMML\">\n  </script>\n  <script type=\"text/x-mathjax-config\">\n    MathJax.Hub.Config({tex2jax: {inlineMath: [['$','$'], ['\\\\(','\\\\)']]},\n                        skipTags: [\"body\"],\n                        processClass: \"bibbase_paper\"});\n  </script>\n\n  <style>\n  @media print {\n    .dontprint {\n        display: none !important;\n    }\n\n  .bibbase_group {\n    background-color: #E0E0E0;\n    font-style: italic;\n    font-size: larger;\n    text-shadow: 0px 0px 3px #FFFFFF;\n    border-radius: 4px 4px 4px 4px;\n    -moz-border-radius: 4px 4px 4px 4px;\n    -webkit-border-radius: 4px;\n    padding: 5px 40px 5px;\n    margin-top: 10px;\n    margin-bottom: 5px;\n    cursor: pointer;\n  }\n\n  .bibbase_paper {\n    margin-bottom: 5px;\n  }\n\n  }\n  </style>\n\n  \n  <div style=\"float: right; margin-right: 10px; margin-top: 10px; text-align: right; font-size: 12px\">\n    generated by\n    <a href=\"//bibbase.org\"\n       onclick=\"trackOutboundLink('bibbase', 'logo clicked', window.location.href, '//bibbase.org'); return false;\">\n      <img src=\"//bibbase.org/img/logo.svg\"\n           style=\"vertical-align: middle; margin-left: 3px; height: 16px;\"/\n           alt=\"bibbase.org\"\n           title=\"BibBase – The easiest way to maintain your publications page.\"\n        ></a>\n    \n  </div>\n  \n\n  <div id=\"bibbase_header\" class=\"dontprint\" style=\"\">\n\n    <ul class=\"nav nav-pills\" style=\"margin: 0px;\">\n\n      <li class=\"dropdown\" id=\"groupby_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\">\n          Group by\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li class=\"groupby year\"><a onclick=\"groupby('year')\">\n            Year</a>\n        </li>\n        <li class=\"groupby author\"><a onclick=\"groupby('author_short')\">\n            Author</a>\n        </li>\n        <li class=\"groupby type\"><a onclick=\"groupby('type')\">\n            Type</a>\n        </li>\n        <li class=\"groupby keyword\"><a onclick=\"groupby('keyword')\">\n            Keyword</a>\n        </li>\n        <li class=\"groupby downloads\"><a onclick=\"groupby('downloads')\">\n            Downloads</a>\n        </li>\n      </ul>\n      </li>\n\n\n      <li class=\"dropdown\" id=\"menu_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\" alt=\"controls\">\n          <i class=\"fa fa-reorder\" alt=\"controls\"></i>\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li>\n          <a onclick=\"toggleAll()\">\n            <i class=\"fa fa-chevron-down fa-fw\"></i> Expand/Collapse All\n          </a>\n        </li>\n        <li>\n          <a download=\"items\" href=\"data:text/bibtex;base64,@article{juneja_current_2022,
	title = {Current role of high dose vitamin {C} in sepsis management: {A} concise review},
	volume = {11},
	issn = {2220-3141},
	shorttitle = {Current role of high dose vitamin {C} in sepsis management},
	url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693906/},
	doi = {10.5492/wjccm.v11.i6.349},
	abstract = {Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality. In addition to aggressive fluid resuscitation and antibiotic therapy, several other drugs have been tried as adjuvant therapies to reduce the inflammatory response and improve outcomes. Vitamin C has been shown to have several biological actions, including anti-inflammatory and immunomodulatory effects, which may prove beneficial in sepsis management. Initial trials showed improved patient outcomes when high dose vitamin C was used in combination with thiamine and hydrocortisone. These results, along with relative safety of high-dose (supra-physiological) vitamin C, encouraged physicians across the globe to add vitamin C as an adjuvant therapy in the management of sepsis. However, subsequent large-scale randomised control trials could not replicate these results, leaving the world divided regarding the role of vitamin C in sepsis management. Here, we discuss the rationale, safety profile, and the current clinical evidence for the use of high-dose vitamin C in the management of sepsis and septic shock.},
	number = {6},
	urldate = {2024-03-07},
	journal = {World Journal of Critical Care Medicine},
	author = {Juneja, Deven and Nasa, Prashant and Jain, Ravi},
	month = nov,
	year = {2022},
	pmid = {36439321},
	pmcid = {PMC9693906},
	pages = {349--363},
}



@article{foster_perspectives_2022,
	title = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study},
	volume = {12},
	issn = {2044-6055, 2044-6055},
	shorttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens},
	url = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537},
	doi = {10.1136/bmjopen-2020-048537},
	abstract = {Objectives
              As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens.
            
            
              Setting
              A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment.
            
            
              Participants
              Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings.
            
            
              Results
              Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it.
            
            
              Conclusions
              Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation.
            
            
              Trial registration number
              ACTRN12615000999538.},
	language = {en},
	number = {1},
	urldate = {2022-03-27},
	journal = {BMJ Open},
	author = {Foster, Juliet and Beasley, Richard and Braithwaite, Irene and Harrison, Tim and Holliday, Mark and Pavord, Ian and Reddel, Helen},
	month = jan,
	year = {2022},
	pages = {e048537},
}



@article{couillard_predicting_2022,
	title = {Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype {Oxford} {Asthma} {Attack} {Risk} {Scale} ({ORACLE})},
	volume = {8},
	issn = {2312-0541},
	url = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021},
	doi = {10.1183/23120541.00570-2021},
	language = {en},
	number = {1},
	urldate = {2022-03-27},
	journal = {ERJ Open Research},
	author = {Couillard, Simon and Do, William Il Hoon and Beasley, Richard and Hinks, Timothy S.C. and Pavord, Ian D.},
	month = jan,
	year = {2022},
	pages = {00570--2021},
}



@article{barnett_thoracic_2022,
	title = {Thoracic {Society} of {Australia} and {New} {Zealand} {Position} {Statement} on {Acute} {Oxygen} {Use} in {Adults}: ‘{Swimming} between the flags’},
	volume = {27},
	issn = {1323-7799, 1440-1843},
	shorttitle = {Thoracic {Society} of {Australia} and {New} {Zealand} {Position} {Statement} on {Acute} {Oxygen} {Use} in {Adults}},
	url = {https://onlinelibrary.wiley.com/doi/10.1111/resp.14218},
	doi = {10.1111/resp.14218},
	language = {en},
	number = {4},
	urldate = {2022-03-27},
	journal = {Respirology},
	author = {Barnett, Adrian and Beasley, Richard and Buchan, Catherine and Chien, Jimmy and Farah, Claude S. and King, Gregory and McDonald, Christine F. and Miller, Belinda and Munsif, Maitri and Psirides, Alex and Reid, Lynette and Roberts, Mary and Smallwood, Natasha and Smith, Sheree},
	month = apr,
	year = {2022},
	pages = {262--276},
}



@article{beasley_evaluation_2022,
	title = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}: {A} {Systematic} {Review} and {Meta}-analysis},
	volume = {5},
	issn = {2574-3805},
	shorttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}},
	url = {https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512},
	doi = {10.1001/jamanetworkopen.2022.0615},
	language = {en},
	number = {3},
	urldate = {2022-03-04},
	journal = {JAMA Network Open},
	author = {Beasley, Richard and Harrison, Tim and Peterson, Stefan and Gustafson, Per and Hamblin, Angus and Bengtsson, Thomas and Fagerås, Malin},
	month = mar,
	year = {2022},
	pages = {e220615},
}



@article{kearns_repeated_2022,
	title = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: {A} randomised cross-over trial},
	issn = {0903-1936, 1399-3003},
	shorttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma},
	url = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021},
	doi = {10.1183/13993003.02309-2021},
	abstract = {Objective
              
                To determine the comparative bronchodilator, systemic beta
                2
                -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma.
              
            
            
              Methods
              
                This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg
                via
                MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg
                via
                nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation
                via
                Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV
                1
                after 180 min. Secondary outcomes included repeat measures of FEV
                1
                , serum potassium, heart rate, and adverse events
              
            
            
              Results
              
                Of 39 patients randomised, two withdrew due to adverse events (QT
                CF
                prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean (
                sd
                ) change from baseline FEV
                1
                180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean (
                sd
                ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95\% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV
                1
                from 30 to 240 min, but lesser FEV
                1
                at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events.
              
            
            
              Conclusion
              
                The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose
                −1
                and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta
                2
                -agonist and cardiovascular effects and more adverse events.},
	language = {en},
	urldate = {2022-03-04},
	journal = {European Respiratory Journal},
	author = {Kearns, Nethmi and Bruce, Pepa and Williams, Mathew and Doppen, Marjan and Black, Melissa and Weatherall, Mark and Beasley, Richard},
	month = feb,
	year = {2022},
	pages = {2102309},
}
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November 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693906/\"\n     onclick=\"log_download('juneja-nasa-jain-currentroleofhighdosevitamincinsepsismanagementaconcisereview-2022', 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693906/', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Current role of high dose vitamin C in sepsis management: A concise review [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.5492/wjccm.v11.i6.349\"\n     onclick=\"log_download('juneja-nasa-jain-currentroleofhighdosevitamincinsepsismanagementaconcisereview-2022', 'http://doi.org/10.5492/wjccm.v11.i6.349', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/juneja-nasa-jain-currentroleofhighdosevitamincinsepsismanagementaconcisereview-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('juneja-nasa-jain-currentroleofhighdosevitamincinsepsismanagementaconcisereview-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{juneja_current_2022,\n\ttitle = {Current role of high dose vitamin {C} in sepsis management: {A} concise review},\n\tvolume = {11},\n\tissn = {2220-3141},\n\tshorttitle = {Current role of high dose vitamin {C} in sepsis management},\n\turl = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693906/},\n\tdoi = {10.5492/wjccm.v11.i6.349},\n\tabstract = {Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality. In addition to aggressive fluid resuscitation and antibiotic therapy, several other drugs have been tried as adjuvant therapies to reduce the inflammatory response and improve outcomes. Vitamin C has been shown to have several biological actions, including anti-inflammatory and immunomodulatory effects, which may prove beneficial in sepsis management. Initial trials showed improved patient outcomes when high dose vitamin C was used in combination with thiamine and hydrocortisone. These results, along with relative safety of high-dose (supra-physiological) vitamin C, encouraged physicians across the globe to add vitamin C as an adjuvant therapy in the management of sepsis. However, subsequent large-scale randomised control trials could not replicate these results, leaving the world divided regarding the role of vitamin C in sepsis management. Here, we discuss the rationale, safety profile, and the current clinical evidence for the use of high-dose vitamin C in the management of sepsis and septic shock.},\n\tnumber = {6},\n\turldate = {2024-03-07},\n\tjournal = {World Journal of Critical Care Medicine},\n\tauthor = {Juneja, Deven and Nasa, Prashant and Jain, Ravi},\n\tmonth = nov,\n\tyear = {2022},\n\tpmid = {36439321},\n\tpmcid = {PMC9693906},\n\tpages = {349--363},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Sepsis and septic shock are common diagnoses for patients requiring intensive care unit admission and associated with high morbidity and mortality. In addition to aggressive fluid resuscitation and antibiotic therapy, several other drugs have been tried as adjuvant therapies to reduce the inflammatory response and improve outcomes. Vitamin C has been shown to have several biological actions, including anti-inflammatory and immunomodulatory effects, which may prove beneficial in sepsis management. Initial trials showed improved patient outcomes when high dose vitamin C was used in combination with thiamine and hydrocortisone. These results, along with relative safety of high-dose (supra-physiological) vitamin C, encouraged physicians across the globe to add vitamin C as an adjuvant therapy in the management of sepsis. However, subsequent large-scale randomised control trials could not replicate these results, leaving the world divided regarding the role of vitamin C in sepsis management. Here, we discuss the rationale, safety profile, and the current clinical evidence for the use of high-dose vitamin C in the management of sepsis and septic shock.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022', 'https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537', event);\">\n    Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Foster, J.; Beasley, R.; Braithwaite, I.; Harrison, T.; Holliday, M.; Pavord, I.;  and Reddel, H.\n</span>\n\n  \n\n</span>\n\n  <i>BMJ Open</i>, 12(1): e048537. January 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537\"\n     onclick=\"log_download('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022', 'https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1136/bmjopen-2020-048537\"\n     onclick=\"log_download('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022', 'http://doi.org/10.1136/bmjopen-2020-048537', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('foster-beasley-braithwaite-harrison-holliday-pavord-reddel-perspectivesofmildasthmapatientsonmaintenanceversusasneededpreventertreatmentregimensaqualitativestudy-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{foster_perspectives_2022,\n\ttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens: a qualitative study},\n\tvolume = {12},\n\tissn = {2044-6055, 2044-6055},\n\tshorttitle = {Perspectives of mild asthma patients on maintenance versus as-needed preventer treatment regimens},\n\turl = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2020-048537},\n\tdoi = {10.1136/bmjopen-2020-048537},\n\tabstract = {Objectives\n              As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens.\n            \n            \n              Setting\n              A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment.\n            \n            \n              Participants\n              Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings.\n            \n            \n              Results\n              Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it.\n            \n            \n              Conclusions\n              Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation.\n            \n            \n              Trial registration number\n              ACTRN12615000999538.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-03-27},\n\tjournal = {BMJ Open},\n\tauthor = {Foster, Juliet and Beasley, Richard and Braithwaite, Irene and Harrison, Tim and Holliday, Mark and Pavord, Ian and Reddel, Helen},\n\tmonth = jan,\n\tyear = {2022},\n\tpages = {e048537},\n}\n\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objectives As-needed low-dose combination budesonide-formoterol is recommended by asthma guidelines in many countries as an alternative to maintenance inhaled corticosteroids (ICS) for treatment of mild asthma, but there are few data on patient attitudes toward these regimens. This study explored the comparative implementation experiences and future treatment preferences of mild asthma patients who had experienced these two treatment regimens. Setting A subgroup of adults randomised to maintenance ICS or as-needed ICS-formoterol in a multinational, 52-week open-label randomised controlled trial (NovelSTART) in mild asthma patients were interviewed to explore their motivations for treatment use during the study and their preferences for future treatment. Participants Semistructured interviews were conducted with 74 participants (Maintenance group: n=39, As-needed group n=35, mean age 38 (range 19–69)) and thematically analysed from transcribed audiorecordings. Results Emergent themes from analysis comprised: ‘How much my asthma affects me’ (how their asthma’s impact affected their self-management motivation); ‘What I know about asthma’ (limited knowledge impeded appropriate self-management decision making); ‘How much effort this treatment regimen involves for me’ (treatment complexity and/or difficulty establishing a medication routine impeded implementation, particularly in the Maintenance group); and ‘My beliefs about the benefits and risks of this treatment’ (patients who considered their treatment as ineffective, eg, limited difference in symptoms relative to salbutamol (both groups) or slower onset of relief (As-needed group) had poor motivation to use the treatment). Due to the simplicity of the as-needed combination strategy, this was the preferred future regimen, even by patients who had not yet tried it. Conclusions Key patient perspectives on the implementation of preventer treatments for mild asthma included factors relating to perceived asthma burden, disease knowledge, treatment complexity and treatment usefulness or safety. The as-needed budesonide-formoterol regimen was preferred to maintenance ICS treatment in mild asthma though patient education is urgently needed to address implementation motivation. Trial registration number ACTRN12615000999538.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022', 'http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021', event);\">\n    Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype Oxford Asthma Attack Risk Scale (ORACLE).\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Couillard, S.; Do, W. I. H.; Beasley, R.; Hinks, T. S.;  and Pavord, I. D.\n</span>\n\n  \n\n</span>\n\n  <i>ERJ Open Research</i>, 8(1): 00570–2021. January 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021\"\n     onclick=\"log_download('couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022', 'http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype Oxford Asthma Attack Risk Scale (ORACLE) [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/23120541.00570-2021\"\n     onclick=\"log_download('couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022', 'http://doi.org/10.1183/23120541.00570-2021', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('couillard-do-beasley-hinks-pavord-predictingthebenefitsoftype2targetedantiinflammatorytreatmentwiththeprototypeoxfordasthmaattackriskscaleoracle-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{couillard_predicting_2022,\n\ttitle = {Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype {Oxford} {Asthma} {Attack} {Risk} {Scale} ({ORACLE})},\n\tvolume = {8},\n\tissn = {2312-0541},\n\turl = {http://openres.ersjournals.com/lookup/doi/10.1183/23120541.00570-2021},\n\tdoi = {10.1183/23120541.00570-2021},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2022-03-27},\n\tjournal = {ERJ Open Research},\n\tauthor = {Couillard, Simon and Do, William Il Hoon and Beasley, Richard and Hinks, Timothy S.C. and Pavord, Ian D.},\n\tmonth = jan,\n\tyear = {2022},\n\tpages = {00570--2021},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"barnett-beasley-buchan-chien-farah-king-mcdonald-miller-etal-thoracicsocietyofaustraliaandnewzealandpositionstatementonacuteoxygenuseinadultsswimmingbetweentheflags-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://onlinelibrary.wiley.com/doi/10.1111/resp.14218\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'barnett-beasley-buchan-chien-farah-king-mcdonald-miller-etal-thoracicsocietyofaustraliaandnewzealandpositionstatementonacuteoxygenuseinadultsswimmingbetweentheflags-2022', 'https://onlinelibrary.wiley.com/doi/10.1111/resp.14218', event);\">\n    Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Barnett, A.; Beasley, R.; Buchan, C.; Chien, J.; Farah, C. S.; King, G.; McDonald, C. F.; Miller, B.; Munsif, M.; Psirides, A.; Reid, L.; Roberts, M.; Smallwood, N.;  and Smith, S.\n</span>\n\n  \n\n</span>\n\n  <i>Respirology</i>, 27(4): 262–276. April 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://onlinelibrary.wiley.com/doi/10.1111/resp.14218\"\n     onclick=\"log_download('barnett-beasley-buchan-chien-farah-king-mcdonald-miller-etal-thoracicsocietyofaustraliaandnewzealandpositionstatementonacuteoxygenuseinadultsswimmingbetweentheflags-2022', 'https://onlinelibrary.wiley.com/doi/10.1111/resp.14218', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1111/resp.14218\"\n     onclick=\"log_download('barnett-beasley-buchan-chien-farah-king-mcdonald-miller-etal-thoracicsocietyofaustraliaandnewzealandpositionstatementonacuteoxygenuseinadultsswimmingbetweentheflags-2022', 'http://doi.org/10.1111/resp.14218', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/barnett-beasley-buchan-chien-farah-king-mcdonald-miller-etal-thoracicsocietyofaustraliaandnewzealandpositionstatementonacuteoxygenuseinadultsswimmingbetweentheflags-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('barnett-beasley-buchan-chien-farah-king-mcdonald-miller-etal-thoracicsocietyofaustraliaandnewzealandpositionstatementonacuteoxygenuseinadultsswimmingbetweentheflags-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{barnett_thoracic_2022,\n\ttitle = {Thoracic {Society} of {Australia} and {New} {Zealand} {Position} {Statement} on {Acute} {Oxygen} {Use} in {Adults}: ‘{Swimming} between the flags’},\n\tvolume = {27},\n\tissn = {1323-7799, 1440-1843},\n\tshorttitle = {Thoracic {Society} of {Australia} and {New} {Zealand} {Position} {Statement} on {Acute} {Oxygen} {Use} in {Adults}},\n\turl = {https://onlinelibrary.wiley.com/doi/10.1111/resp.14218},\n\tdoi = {10.1111/resp.14218},\n\tlanguage = {en},\n\tnumber = {4},\n\turldate = {2022-03-27},\n\tjournal = {Respirology},\n\tauthor = {Barnett, Adrian and Beasley, Richard and Buchan, Catherine and Chien, Jimmy and Farah, Claude S. and King, Gregory and McDonald, Christine F. and Miller, Belinda and Munsif, Maitri and Psirides, Alex and Reid, Lynette and Roberts, Mary and Smallwood, Natasha and Smith, Sheree},\n\tmonth = apr,\n\tyear = {2022},\n\tpages = {262--276},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022', 'https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512', event);\">\n    Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma: A Systematic Review and Meta-analysis.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Beasley, R.; Harrison, T.; Peterson, S.; Gustafson, P.; Hamblin, A.; Bengtsson, T.;  and Fagerås, M.\n</span>\n\n  \n\n</span>\n\n  <i>JAMA Network Open</i>, 5(3): e220615. March 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512\"\n     onclick=\"log_download('beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022', 'https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma: A Systematic Review and Meta-analysis [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1001/jamanetworkopen.2022.0615\"\n     onclick=\"log_download('beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022', 'http://doi.org/10.1001/jamanetworkopen.2022.0615', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('beasley-harrison-peterson-gustafson-hamblin-bengtsson-fagers-evaluationofbudesonideformoterolformaintenanceandrelievertherapyamongpatientswithpoorlycontrolledasthmaasystematicreviewandmetaanalysis-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{beasley_evaluation_2022,\n\ttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}: {A} {Systematic} {Review} and {Meta}-analysis},\n\tvolume = {5},\n\tissn = {2574-3805},\n\tshorttitle = {Evaluation of {Budesonide}-{Formoterol} for {Maintenance} and {Reliever} {Therapy} {Among} {Patients} {With} {Poorly} {Controlled} {Asthma}},\n\turl = {https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789512},\n\tdoi = {10.1001/jamanetworkopen.2022.0615},\n\tlanguage = {en},\n\tnumber = {3},\n\turldate = {2022-03-04},\n\tjournal = {JAMA Network Open},\n\tauthor = {Beasley, Richard and Harrison, Tim and Peterson, Stefan and Gustafson, Per and Hamblin, Angus and Bengtsson, Thomas and Fagerås, Malin},\n\tmonth = mar,\n\tyear = {2022},\n\tpages = {e220615},\n}\n\n</pre>\n</div>\n\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021', event);\">\n    Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: A randomised cross-over trial.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Kearns, N.; Bruce, P.; Williams, M.; Doppen, M.; Black, M.; Weatherall, M.;  and Beasley, R.\n</span>\n\n  \n\n</span>\n\n  <i>European Respiratory Journal</i>,2102309. February 2022.\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021\"\n     onclick=\"log_download('kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022', 'http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: A randomised cross-over trial [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1183/13993003.02309-2021\"\n     onclick=\"log_download('kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022', 'http://doi.org/10.1183/13993003.02309-2021', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('kearns-bruce-williams-doppen-black-weatherall-beasley-repeateddosebudesonideformoterolcomparedtosalbutamolinadultasthmaarandomisedcrossovertrial-2022')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@article{kearns_repeated_2022,\n\ttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma: {A} randomised cross-over trial},\n\tissn = {0903-1936, 1399-3003},\n\tshorttitle = {Repeated dose budesonide/formoterol compared to salbutamol in adult asthma},\n\turl = {http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02309-2021},\n\tdoi = {10.1183/13993003.02309-2021},\n\tabstract = {Objective\n              \n                To determine the comparative bronchodilator, systemic beta\n                2\n                -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma.\n              \n            \n            \n              Methods\n              \n                This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg\n                via\n                MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg\n                via\n                nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation\n                via\n                Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV\n                1\n                after 180 min. Secondary outcomes included repeat measures of FEV\n                1\n                , serum potassium, heart rate, and adverse events\n              \n            \n            \n              Results\n              \n                Of 39 patients randomised, two withdrew due to adverse events (QT\n                CF\n                prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean (\n                sd\n                ) change from baseline FEV\n                1\n                180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean (\n                sd\n                ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95\\% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV\n                1\n                from 30 to 240 min, but lesser FEV\n                1\n                at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events.\n              \n            \n            \n              Conclusion\n              \n                The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose\n                −1\n                and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta\n                2\n                -agonist and cardiovascular effects and more adverse events.},\n\tlanguage = {en},\n\turldate = {2022-03-04},\n\tjournal = {European Respiratory Journal},\n\tauthor = {Kearns, Nethmi and Bruce, Pepa and Williams, Mathew and Doppen, Marjan and Black, Melissa and Weatherall, Mark and Beasley, Richard},\n\tmonth = feb,\n\tyear = {2022},\n\tpages = {2102309},\n}\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objective To determine the comparative bronchodilator, systemic beta 2 -agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma. Methods This open-label, cross-over, single-centre, controlled trial, randomised adults with asthma to different orders of two treatment regimens: salbutamol 200 µg via MDI at t=0, 30, 60, 90 min, then salbutamol 2.5 mg via nebuliser at t=120, 140, 160 and 420 min; or budesonide/formoterol 200/6 µg one actuation via Turbuhaler at t=0, 30, 60, 90 min, two actuations at t=120, 140, 160 and 420 min. The primary outcome measure was FEV 1 after 180 min. Secondary outcomes included repeat measures of FEV 1 , serum potassium, heart rate, and adverse events Results Of 39 patients randomised, two withdrew due to adverse events (QT CF prolongation and T wave abnormalities) after the first intervention with salbutamol. The mean ( sd ) change from baseline FEV 1 180 min after randomisation for salbutamol and budesonide/formoterol regimens was 0.71 (0.46) L, N=38, and 0.58 (0.45) L, N=37, respectively; with a mean ( sd ) paired difference of −0.10 (0.40) L, N=37, and a model-based estimated difference (95% CI) −0.12 (−0.25 to 0.02) L, p=0.088. In the main secondary analysis, salbutamol resulted in significantly greater FEV 1 from 30 to 240 min, but lesser FEV 1 at 360 and 420 min. Salbutamol resulted in a significantly lower serum potassium, and a higher heart rate and number of adverse events. Conclusion The comparative bronchodilator responses of repeated administration of salbutamol 200 µg dose −1 and budesonide/formoterol 200/6 µg differed depending on the time of measurement. Salbutamol caused greater systemic beta 2 -agonist and cardiovascular effects and more adverse events.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n\n\n\n  </div>\n\n\n  <!-- Modal -->\n\n  <!-- <iframe id=\"bibbase_network_frame\" -->\n  <!--         src=\"//bibbase.org/network/control\" -->\n  <!--         style=\"display: none;\"> -->\n  <!-- </iframe> -->\n\n</div>\n"}; document.write(bibbase_data.data);