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\n\n \n \n \n \n \n \n Association between paracetamol use in infancy or childhood with body mass index.\n \n \n \n \n\n\n \n Murphy, R.; Stewart, A. W; Braithwaite, I.; Beasley, R.; Hancox, R. J; Mitchell, E. A; and Group, t. I. P. T. S.\n\n\n \n\n\n\n
Obesity, 23(5): 1030–1038. May 2015.\n
Number: 5 Publisher: John Wiley & Sons, Ltd\n\n
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@article{murphy_association_2015,\n\ttitle = {Association between paracetamol use in infancy or childhood with body mass index},\n\tvolume = {23},\n\tissn = {1930-7381},\n\turl = {https://doi.org/10.1002/oby.21045},\n\tdoi = {10.1002/oby.21045},\n\tabstract = {Objective Paracetamol has the potential to also promote weight gain by indirect activation of cannabinoid receptors. The association between paracetamol use in the first 12 months of life or recent high use and BMI in children and adolescents was investigated. Methods Paracetamol use in the first 12 months of life (reported by parents/guardians of 6- and 7-year-olds) or in the past 12 months (reported by parents/guardians of 6- and 7-year-olds or self-reported by adolescents aged 13?14) was examined in relation to BMI in a large multicentre cross-sectional study (2000?2003). Linear regression results were adjusted for whether height and weight were reported or measured, age, sex, country gross national income, study centre, maternal smoking, and recent wheeze. Results Data were available from 76,216 children (18 countries) and 188,469 adolescents (35 countries). BMI was +0.07 kg/m2 higher in children with early life paracetamol exposure, from affluent countries only. Frequent recent paracetamol use was associated with higher BMI (+0.17 kg/m2, P?{\\textbackslash}textless?0.0001) among adolescents from affluent countries only, but not in children (P?=?0.41). Conclusions Paracetamol may be causally related to increased BMI; alternatively, the association may be explained by lifestyle or other factors that correlate with paracetamol use in affluent countries.},\n\tnumber = {5},\n\tjournal = {Obesity},\n\tauthor = {Murphy, Rinki and Stewart, Alistair W and Braithwaite, Irene and Beasley, Richard and Hancox, Robert J and Mitchell, Edwin A and Group, the ISAAC Phase Three Study},\n\tmonth = may,\n\tyear = {2015},\n\tnote = {Number: 5\nPublisher: John Wiley \\& Sons, Ltd},\n\tpages = {1030--1038},\n}\n\n\n
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\n Objective Paracetamol has the potential to also promote weight gain by indirect activation of cannabinoid receptors. The association between paracetamol use in the first 12 months of life or recent high use and BMI in children and adolescents was investigated. Methods Paracetamol use in the first 12 months of life (reported by parents/guardians of 6- and 7-year-olds) or in the past 12 months (reported by parents/guardians of 6- and 7-year-olds or self-reported by adolescents aged 13?14) was examined in relation to BMI in a large multicentre cross-sectional study (2000?2003). Linear regression results were adjusted for whether height and weight were reported or measured, age, sex, country gross national income, study centre, maternal smoking, and recent wheeze. Results Data were available from 76,216 children (18 countries) and 188,469 adolescents (35 countries). BMI was +0.07 kg/m2 higher in children with early life paracetamol exposure, from affluent countries only. Frequent recent paracetamol use was associated with higher BMI (+0.17 kg/m2, P?\\textless?0.0001) among adolescents from affluent countries only, but not in children (P?=?0.41). Conclusions Paracetamol may be causally related to increased BMI; alternatively, the association may be explained by lifestyle or other factors that correlate with paracetamol use in affluent countries.\n
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\n\n \n \n \n \n \n \n Association between breastfeeding and body mass index at age 6–7 years in an international survey.\n \n \n \n \n\n\n \n Hancox, R J; Stewart, A W; Braithwaite, I; Beasley, R; Murphy, R; Mitchell, E A; and Group, I. P. T. S.\n\n\n \n\n\n\n
Pediatric Obesity, 10(4): 283–287. August 2015.\n
Number: 4 Publisher: John Wiley & Sons, Ltd (10.1111)\n\n
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@article{hancox_association_2015,\n\ttitle = {Association between breastfeeding and body mass index at age 6–7 years in an international survey},\n\tvolume = {10},\n\tissn = {2047-6302},\n\turl = {https://doi.org/10.1111/ijpo.266},\n\tdoi = {10.1111/ijpo.266},\n\tabstract = {Summary Background Breastfeeding is believed to reduce children's risk for obesity but data are conflicting. It is also uncertain if breastfeeding has different effects on obesity in high- and low-income countries. Objectives This study aimed to investigate the association between having been breastfed and body mass index (BMI) in 6- to 7-year-old children in a large international survey. Methods Parents/guardians reported whether their child had been breastfed and their current height and weight. Some centres measured height and weight directly. Analyses adjusted for whether height and weight were reported or measured, child's age, sex, country gross national income and centre. Results Data were available for 76?635 participants from 31 centres in 18 countries. Reported breastfeeding rates varied from 27 to 98\\%. After adjusting for potential confounders, the estimated BMI difference was 0.04?kg?m?2 lower among those who had been breastfed (P?=?0.07). The risk for being overweight or obese was slightly lower among breastfed children (odds ratio?=?0.95, P?=?0.012). There was no evidence that the association between breastfeeding and BMI was different in lower income countries compared with higher income countries. Conclusions The findings suggest that breastfeeding has little impact on children's BMI. Increasing breastfeeding is unlikely to reduce the global epidemic of childhood obesity.},\n\tnumber = {4},\n\tjournal = {Pediatric Obesity},\n\tauthor = {Hancox, R J and Stewart, A W and Braithwaite, I and Beasley, R and Murphy, R and Mitchell, E A and Group, ISAAC Phase Three Study},\n\tmonth = aug,\n\tyear = {2015},\n\tnote = {Number: 4\nPublisher: John Wiley \\& Sons, Ltd (10.1111)},\n\tkeywords = {Body mass index, breastfeeding, children, obesity},\n\tpages = {283--287},\n}\n\n
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\n Summary Background Breastfeeding is believed to reduce children's risk for obesity but data are conflicting. It is also uncertain if breastfeeding has different effects on obesity in high- and low-income countries. Objectives This study aimed to investigate the association between having been breastfed and body mass index (BMI) in 6- to 7-year-old children in a large international survey. Methods Parents/guardians reported whether their child had been breastfed and their current height and weight. Some centres measured height and weight directly. Analyses adjusted for whether height and weight were reported or measured, child's age, sex, country gross national income and centre. Results Data were available for 76?635 participants from 31 centres in 18 countries. Reported breastfeeding rates varied from 27 to 98%. After adjusting for potential confounders, the estimated BMI difference was 0.04?kg?m?2 lower among those who had been breastfed (P?=?0.07). The risk for being overweight or obese was slightly lower among breastfed children (odds ratio?=?0.95, P?=?0.012). There was no evidence that the association between breastfeeding and BMI was different in lower income countries compared with higher income countries. Conclusions The findings suggest that breastfeeding has little impact on children's BMI. Increasing breastfeeding is unlikely to reduce the global epidemic of childhood obesity.\n
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