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\n  \n 2025\n \n \n (2)\n \n \n
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\n \n\n \n \n \n \n \n Structural alterations during fracture healing lead to void spaces developing in surrounding bone microarchitecture.\n \n \n \n\n\n \n Whittier, D. E; Walle, M.; Atkins, P. R; Collins, C. J; Zumstein, M. A; Christen, P.; Lippuner, K.; and Müller, R.\n\n\n \n\n\n\n Journal of Bone and Mineral Research,zjaf046. 2025.\n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{whittier2025structural,\n  title={Structural alterations during fracture healing lead to void spaces developing in surrounding bone microarchitecture},\n  author={Whittier, Danielle E and Walle, Matthias and Atkins, Penny R and Collins, Caitlyn J and Zumstein, Matthias A and Christen, Patrik and Lippuner, Kurt and M{\\"u}ller, Ralph},\n  journal={Journal of Bone and Mineral Research},\n  pages={zjaf046},\n  year={2025},\n  publisher={Oxford University Press}\n}\n\n
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\n \n\n \n \n \n \n \n Comparing Linear and Nonlinear Finite Element Models of Vertebral Strength Across the Thoracolumbar Spine: A Benchmark from Density-Calibrated Computed Tomography.\n \n \n \n\n\n \n Walle, M.; Matheson, B. E; and Boyd, S. K\n\n\n \n\n\n\n bioRxiv,2025–04. 2025.\n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{walle2025comparing,\n  title={Comparing Linear and Nonlinear Finite Element Models of Vertebral Strength Across the Thoracolumbar Spine: A Benchmark from Density-Calibrated Computed Tomography},\n  author={Walle, Matthias and Matheson, Bryn E and Boyd, Steven K},\n  journal={bioRxiv},\n  pages={2025--04},\n  year={2025},\n  publisher={Cold Spring Harbor Laboratory}\n}
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\n \n\n \n \n \n \n \n Quantitative 31P magnetic resonance imaging on pathologic rat bones by ZTE at 7T.\n \n \n \n\n\n \n Kassey, V. B; Walle, M.; Egan, J.; Yeritsyan, D.; Beeram, I.; Wu, Y.; Snyder, B. D; Rodriguez, E. K; Ackerman, J. L; and Nazarian, A.\n\n\n \n\n\n\n Bone, 180: 116996. 2024.\n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{kassey2024quantitative,\n  title={Quantitative 31P magnetic resonance imaging on pathologic rat bones by ZTE at 7T},\n  author={Kassey, Victor B and Walle, Matthias and Egan, Jonathan and Yeritsyan, Diana and Beeram, Indeevar and Wu, Yaotang and Snyder, Brian D and Rodriguez, Edward K and Ackerman, Jerome L and Nazarian, Ara},\n  journal={Bone},\n  volume={180},\n  pages={116996},\n  year={2024},\n  publisher={Elsevier}\n}\n\n
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\n \n\n \n \n \n \n \n Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus.\n \n \n \n\n\n \n Walle, M.; Duseja, A.; Whittier, D. E; Vilaca, T.; Paggiosi, M.; Eastell, R.; Müller, R.; and Collins, C. J\n\n\n \n\n\n\n Journal of Bone and Mineral Research, 39(2): 85–94. 2024.\n \n\n\n\n
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@article{walle2024bone,\n  title={Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus},\n  author={Walle, Matthias and Duseja, Ankita and Whittier, Danielle E and Vilaca, Tatiane and Paggiosi, Margaret and Eastell, Richard and M{\\"u}ller, Ralph and Collins, Caitlyn J},\n  journal={Journal of Bone and Mineral Research},\n  volume={39},\n  number={2},\n  pages={85--94},\n  year={2024},\n  publisher={Oxford University Press}\n}\n\n
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\n \n\n \n \n \n \n \n quantitative 1H Magnetic Resonance Imaging on Normal and Pathologic Rat Bones by Solid-State 1H ZTE Sequence with Water and Fat Suppression.\n \n \n \n\n\n \n Kassey, V.; Walle, M.; Egan, J.; Yeritsyan, D.; Beeram, I.; Kassey, S. P; Wu, Y.; Snyder, B. D; Rodriguez, E. K; Ackerman, J. L; and others\n\n\n \n\n\n\n Journal of Magnetic Resonance Imaging, 60(6): 2423–2432. 2024.\n \n\n\n\n
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@article{kassey2024quantitative,\n  title={quantitative 1H Magnetic Resonance Imaging on Normal and Pathologic Rat Bones by Solid-State 1H ZTE Sequence with Water and Fat Suppression},\n  author={Kassey, V{\\'\\i}ctor B and Walle, Matthias and Egan, Jonathan and Yeritsyan, Diana and Beeram, Indeevar and Kassey, Sharon P and Wu, Yaotang and Snyder, Brian D and Rodriguez, Edward K and Ackerman, Jerome L and others},\n  journal={Journal of Magnetic Resonance Imaging},\n  volume={60},\n  number={6},\n  pages={2423--2432},\n  year={2024},\n  publisher={John Wiley \\& Sons, Inc. Hoboken, USA}\n}\n\n
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\n \n\n \n \n \n \n \n A graph model to describe the network connectivity of trabecular plates and rods.\n \n \n \n\n\n \n Walle, M.; Yeritsyan, D.; Abbasian, M.; Oftadeh, R.; Müller, R.; and Nazarian, A.\n\n\n \n\n\n\n Frontiers in Bioengineering and Biotechnology, 12: 1384280. 2024.\n \n\n\n\n
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@article{walle2024graph,\n  title={A graph model to describe the network connectivity of trabecular plates and rods},\n  author={Walle, Matthias and Yeritsyan, Diana and Abbasian, Mohammadreza and Oftadeh, Ramin and M{\\"u}ller, Ralph and Nazarian, Ara},\n  journal={Frontiers in Bioengineering and Biotechnology},\n  volume={12},\n  pages={1384280},\n  year={2024},\n  publisher={Frontiers Media SA}\n}\n\n
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\n \n\n \n \n \n \n \n Non-Invasive Automatic Assessment of Vertebral Strength in Cancer Patients with and without Bone Metastasis.\n \n \n \n\n\n \n Walle, M.; Matheson, B.; Abbott, A.; Ye, C.; Monument, M. J; and Boyd, S. K\n\n\n \n\n\n\n In ASBMR 2024 Annual Meeting, 2024. ASBMR\n \n\n\n\n
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@inproceedings{walle2024non,\n  title={Non-Invasive Automatic Assessment of Vertebral Strength in Cancer Patients with and without Bone Metastasis},\n  author={Walle, Matthias and Matheson, Bryn and Abbott, Annalise and Ye, Carrie and Monument, Michael J and Boyd, Steven K},\n  booktitle={ASBMR 2024 Annual Meeting},\n  year={2024},\n  organization={ASBMR}\n}\n\n
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\n \n\n \n \n \n \n \n Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans.\n \n \n \n\n\n \n Walle, M.; Gabel, L.; Whittier, D. E; Liphardt, A.; Hulme, P. A; Heer, M.; Zwart, S. R; Smith, S. M; Sibonga, J. D; and Boyd, S. K\n\n\n \n\n\n\n Science Advances, 10(51): eadq3632. 2024.\n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{walle2024tracking,\n  title={Tracking of spaceflight-induced bone remodeling reveals a limited time frame for recovery of resorption sites in humans},\n  author={Walle, Matthias and Gabel, Leigh and Whittier, Danielle E and Liphardt, Anna-Maria and Hulme, Paul A and Heer, Martina and Zwart, Sara R and Smith, Scott M and Sibonga, Jean D and Boyd, Steven K},\n  journal={Science Advances},\n  volume={10},\n  number={51},\n  pages={eadq3632},\n  year={2024},\n  publisher={American Association for the Advancement of Science}\n}\n\n
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\n \n\n \n \n \n \n \n Investigating the Time-Dependent Recovery of Spaceflight-Induced Bone Resorption in Astronauts.\n \n \n \n\n\n \n Walle, M.; Gabel, L.; Whittier, D.; Liphardt, A.; Hulme, P.; Heer, M.; Zwart, S.; Smith, S.; Sibonga, J. D; and Boyd, S. K\n\n\n \n\n\n\n In JOURNAL OF BONE AND MINERAL RESEARCH, volume 39, pages 74–74, 2024. OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND\n \n\n\n\n
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@inproceedings{walle2024investigating,\n  title={Investigating the Time-Dependent Recovery of Spaceflight-Induced Bone Resorption in Astronauts},\n  author={Walle, Matthias and Gabel, Leigh and Whittier, Danielle and Liphardt, Anna-Maria and Hulme, Paul and Heer, Martina and Zwart, Sara and Smith, Scott and Sibonga, Jean D and Boyd, Steven K},\n  booktitle={JOURNAL OF BONE AND MINERAL RESEARCH},\n  volume={39},\n  pages={74--74},\n  year={2024},\n  organization={OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND}\n}\n\n
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\n \n\n \n \n \n \n \n Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks.\n \n \n \n\n\n \n Walle, M.; Eggemann, D.; Atkins, P. R; Kendall, J. J; Stock, K.; Müller, R.; and Collins, C. J\n\n\n \n\n\n\n Bone, 166: 116607. 2023.\n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{walle2023motion,\n  title={Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks},\n  author={Walle, Matthias and Eggemann, Dominic and Atkins, Penny R and Kendall, Jack J and Stock, Kerstin and M{\\"u}ller, Ralph and Collins, Caitlyn J},\n  journal={Bone},\n  volume={166},\n  pages={116607},\n  year={2023},\n  publisher={Elsevier}\n}\n\n
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\n \n\n \n \n \n \n \n Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency.\n \n \n \n\n\n \n Marques, F. C; Boaretti, D.; Walle, M.; Scheuren, A. C; Schulte, F. A; and Müller, R.\n\n\n \n\n\n\n Frontiers in Bioengineering and Biotechnology, 11: 1140673. 2023.\n \n\n\n\n
\n\n\n\n \n\n \n\n \n link\n  \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n  \n \n \n\n\n\n
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@article{marques2023mechanostat,\n  title={Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency},\n  author={Marques, Francisco C and Boaretti, Daniele and Walle, Matthias and Scheuren, Ariane C and Schulte, Friederike A and M{\\"u}ller, Ralph},\n  journal={Frontiers in Bioengineering and Biotechnology},\n  volume={11},\n  pages={1140673},\n  year={2023},\n  publisher={Frontiers Media SA}\n}\n\n
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\n \n\n \n \n \n \n \n Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo.\n \n \n \n\n\n \n Walle, M.; Whittier, D. E; Schenk, D.; Atkins, P. R; Blauth, M.; Zysset, P.; Lippuner, K.; Müller, R.; and Collins, C. J\n\n\n \n\n\n\n Bone, 172: 116780. 2023.\n \n\n\n\n
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@article{walle2023precision,\n  title={Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo},\n  author={Walle, Matthias and Whittier, Danielle E and Schenk, Denis and Atkins, Penny R and Blauth, Michael and Zysset, Philippe and Lippuner, Kurt and M{\\"u}ller, Ralph and Collins, Caitlyn J},\n  journal={Bone},\n  volume={172},\n  pages={116780},\n  year={2023},\n  publisher={Elsevier}\n}\n\n
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\n \n\n \n \n \n \n \n A multi-stack registration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans.\n \n \n \n\n\n \n Whittier, D. E; Walle, M.; Schenk, D.; Atkins, P. R; Collins, C. J; Zysset, P.; Lippuner, K.; and Müller, R.\n\n\n \n\n\n\n Bone, 176: 116893. 2023.\n \n\n\n\n
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@article{whittier2023multi,\n  title={A multi-stack registration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans},\n  author={Whittier, Danielle E and Walle, Matthias and Schenk, Denis and Atkins, Penny R and Collins, Caitlyn J and Zysset, Philippe and Lippuner, Kurt and M{\\"u}ller, Ralph},\n  journal={Bone},\n  volume={176},\n  pages={116893},\n  year={2023},\n  publisher={Elsevier}\n}\n\n
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\n \n\n \n \n \n \n \n Mechanoregulation of Bone Remodelling in Diabetes Mellitus using High-Resolution Peripheral Quantitative Computed Tomography In Vivo Patient Data.\n \n \n \n\n\n \n Walle, M.\n\n\n \n\n\n\n Ph.D. Thesis, ETH Zurich, 2023.\n \n\n\n\n
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@phdthesis{walle2023mechanoregulation,\n  title={Mechanoregulation of Bone Remodelling in Diabetes Mellitus using High-Resolution Peripheral Quantitative Computed Tomography In Vivo Patient Data},\n  author={Walle, Matthias},\n  year={2023},\n  school={ETH Zurich}\n}\n\n
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\n \n\n \n \n \n \n \n Current practices and access to cardiac bone scans for the detection of transthyretin cardiac amyloidosis based on the results of a large national electronic survey.\n \n \n \n\n\n \n Hyafil, F; Amara, W; Bardin, T; Bouquillon, B; Canali, G; Dubois, M; Fournier, P; Guignard, S; Labeyrie, C; Legallois, D; and others\n\n\n \n\n\n\n In EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, volume 50, pages S381–S382, 2023. SPRINGER ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES\n \n\n\n\n
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@inproceedings{hyafil2023current,\n  title={Current practices and access to cardiac bone scans for the detection of transthyretin cardiac amyloidosis based on the results of a large national electronic survey},\n  author={Hyafil, F and Amara, W and Bardin, T and Bouquillon, B and Canali, G and Dubois, M and Fournier, P and Guignard, S and Labeyrie, C and Legallois, D and others},\n  booktitle={EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING},\n  volume={50},\n  number={SUPPL 1},\n  pages={S381--S382},\n  year={2023},\n  organization={SPRINGER ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES}\n}\n\n
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\n \n\n \n \n \n \n \n Fracture Healing Leads to Localized Structural Bone Loss Quantified using Void Space Analysis.\n \n \n \n\n\n \n Whittier, D.; Walle, M.; Ledoux, C.; Atkins, P.; Collins, C.; Holtmann, J.; Zumstein, M.; Christen, P.; Lippuner, K.; and Mueller, R.\n\n\n \n\n\n\n In JOURNAL OF BONE AND MINERAL RESEARCH, volume 38, pages 261–261, 2023. OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND\n \n\n\n\n
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@inproceedings{whittier2023fracture,\n  title={Fracture Healing Leads to Localized Structural Bone Loss Quantified using Void Space Analysis},\n  author={Whittier, Danielle and Walle, Matthias and Ledoux, Charles and Atkins, Penny and Collins, Caitlyn and Holtmann, Julia and Zumstein, Matthias and Christen, Patrik and Lippuner, Kurt and Mueller, Ralph},\n  booktitle={JOURNAL OF BONE AND MINERAL RESEARCH},\n  volume={38},\n  pages={261--261},\n  year={2023},\n  organization={OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND}\n}\n\n
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\n \n\n \n \n \n \n \n Bone remodelling and responsiveness to mechanical stimuli in type 1 diabetes mellitus: the role of neuropathy.\n \n \n \n\n\n \n Walle, M.; Duseja, A.; Whittier, D.; Vilaca, T.; Paggiosi, M.; Eastell, R.; Mueller, R.; and Collins, C.\n\n\n \n\n\n\n In JOURNAL OF BONE AND MINERAL RESEARCH, volume 38, pages 390–390, 2023. OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND\n \n\n\n\n
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@inproceedings{walle2023bone,\n  title={Bone remodelling and responsiveness to mechanical stimuli in type 1 diabetes mellitus: the role of neuropathy},\n  author={Walle, Matthias and Duseja, Ankita and Whittier, Danielle and Vilaca, Tatiane and Paggiosi, Margaret and Eastell, Richard and Mueller, Ralph and Collins, Caitlyn},\n  booktitle={JOURNAL OF BONE AND MINERAL RESEARCH},\n  volume={38},\n  pages={390--390},\n  year={2023},\n  organization={OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND}\n}\n\n
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\n \n\n \n \n \n \n \n Correction of motion Artefacts in HR-pQCT using Cycle-Consistent Adversarial Networks.\n \n \n \n\n\n \n Steiner, P. Y; Walle, M.; Rigotti, M.; Whittier, D. E; McLennan, C.; Atkins, P. R; Müller, R.; and Collins, C. J\n\n\n \n\n\n\n In Congress of the European Society of Biomechanics, 2022. \n \n\n\n\n
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@inproceedings{steiner2022correction,\n  title={Correction of motion Artefacts in HR-pQCT using Cycle-Consistent Adversarial Networks},\n  author={Steiner, Philipp Y and Walle, Matthias and Rigotti, Mattia and Whittier, Danielle E and McLennan, Cael and Atkins, Penny R and M{\\"u}ller, Ralph and Collins, Caitlyn J},\n  booktitle={Congress of the European Society of Biomechanics},\n  year={2022}\n}\n\n
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\n \n\n \n \n \n \n \n Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography.\n \n \n \n\n\n \n Walle, M.; Whittier, D. E; Frost, M.; Müller, R.; and Collins, C. J\n\n\n \n\n\n\n Current osteoporosis reports, 20(6): 398–409. 2022.\n \n\n\n\n
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@article{walle2022meta,\n  title={Meta-analysis of diabetes mellitus-associated differences in bone structure assessed by high-resolution peripheral quantitative computed tomography},\n  author={Walle, Matthias and Whittier, Danielle E and Frost, Morten and M{\\"u}ller, Ralph and Collins, Caitlyn J},\n  journal={Current osteoporosis reports},\n  volume={20},\n  number={6},\n  pages={398--409},\n  year={2022},\n  publisher={Springer US New York}\n}\n\n
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\n  \n 2021\n \n \n (2)\n \n \n
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\n \n\n \n \n \n \n \n Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect.\n \n \n \n\n\n \n Malhotra, A.; Walle, M.; Paul, G. R; Kuhn, G. A; and Müller, R.\n\n\n \n\n\n\n Scientific reports, 11(1): 1861. 2021.\n \n\n\n\n
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@article{malhotra2021application,\n  title={Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect},\n  author={Malhotra, Angad and Walle, Matthias and Paul, Graeme R and Kuhn, Gisela A and M{\\"u}ller, Ralph},\n  journal={Scientific reports},\n  volume={11},\n  number={1},\n  pages={1861},\n  year={2021},\n  publisher={Nature Publishing Group UK London}\n}\n\n
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\n \n\n \n \n \n \n \n Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo.\n \n \n \n\n\n \n Walle, M.; Marques, F. C; Ohs, N.; Blauth, M.; Müller, R.; and Collins, C. J\n\n\n \n\n\n\n Frontiers in Bioengineering and Biotechnology, 9: 486. 2021.\n \n\n\n\n
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@article{walle2021bone,\n  title={Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo},\n  author={Walle, Matthias and Marques, Francisco C and Ohs, Nicholas and Blauth, Michael and M{\\"u}ller, Ralph and Collins, Caitlyn J},\n  journal={Frontiers in Bioengineering and Biotechnology},\n  volume={9},\n  pages={486},\n  year={2021}\n}\n\n
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