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\n  \n 2025\n \n \n (3)\n \n \n
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\n \n\n \n \n \n \n \n Drug repurposing in amyotrophic lateral sclerosis (ALS).\n \n \n \n\n\n \n Carroll, E.; Scaber, J.; Huber, K. V. M.; Brennan, P. E.; Thompson, A. G.; Turner, M. R.; and Talbot, K.\n\n\n \n\n\n\n EXPERT OPINION ON DRUG DISCOVERY, 20(4): 447-464. APR 3 2025.\n \n\n\n\n
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@article{ WOS:001439169100001,\nAuthor = {Carroll, Emily and Scaber, Jakub and Huber, Kilian V. M. and Brennan,\n   Paul E. and Thompson, Alexander G. and Turner, Martin R. and Talbot,\n   Kevin},\nTitle = {Drug repurposing in amyotrophic lateral sclerosis (ALS)},\nJournal = {EXPERT OPINION ON DRUG DISCOVERY},\nYear = {2025},\nVolume = {20},\nNumber = {4},\nPages = {447-464},\nMonth = {APR 3},\nDOI = {10.1080/17460441.2025.2474661},\nEarlyAccessDate = {MAR 2025},\nISSN = {1746-0441},\nEISSN = {1746-045X},\nResearcherID-Numbers = {Thompson, Alexander/GXG-5589-2022\n   Talbot, Kevin/F-7361-2011\n   Huber, Kilian/L-6921-2015},\nORCID-Numbers = {Huber, Kilian/0000-0002-1103-5300},\nUnique-ID = {WOS:001439169100001},\n}\n\n
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\n \n\n \n \n \n \n \n Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor.\n \n \n \n\n\n \n O'Brien, D. P.; Jones, H. B. L.; Shi, Y.; Guenther, F.; Vendrell, I.; Viner, R.; Brennan, P. E.; Mead, E.; Zarganes-Tzitzikas, T.; Davis, J. B.; Pinto-Fernandez, A.; England, K. S.; Murphy, E. J.; Turnbull, A. P.; and Kessler, B. M.\n\n\n \n\n\n\n JOURNAL OF PROTEOME RESEARCH, 24(2): 479-490. JAN 13 2025.\n \n\n\n\n
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@article{ WOS:001395571100001,\nAuthor = {O'Brien, Darragh P. and Jones, Hannah B. L. and Shi, Yuqi and Guenther,\n   Franziska and Vendrell, Iolanda and Viner, Rosa and Brennan, Paul E. and\n   Mead, Emma and Zarganes-Tzitzikas, Tryfon and Davis, John B. and\n   Pinto-Fernandez, Adan and England, Katherine S. and Murphy, Emma J. and\n   Turnbull, Andrew P. and Kessler, Benedikt M.},\nTitle = {Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex\n   with a Cyanopyrrolidine-Containing Covalent Inhibitor},\nJournal = {JOURNAL OF PROTEOME RESEARCH},\nYear = {2025},\nVolume = {24},\nNumber = {2},\nPages = {479-490},\nMonth = {JAN 13},\nDOI = {10.1021/acs.jproteome.4c00618},\nEarlyAccessDate = {JAN 2025},\nISSN = {1535-3893},\nEISSN = {1535-3907},\nResearcherID-Numbers = {Kessler, Benedikt/JGC-6978-2023\n   },\nORCID-Numbers = {O'Brien, Darragh P./0000-0003-4924-7795\n   Guenther, Franziska/0000-0002-7920-7877\n   Kessler, Benedikt/0000-0002-8160-2446\n   Zarganes - Tzitzikas, Tryfon/0000-0001-7323-8587\n   Jones, Hannah/0000-0002-7834-0625},\nUnique-ID = {WOS:001395571100001},\n}\n\n
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\n \n\n \n \n \n \n \n Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors.\n \n \n \n\n\n \n Mackinnon, S. R.; Zarganes-Tzitzikas, T.; Adams, C. J.; Brennan, P. E.; and Yue, W. W.\n\n\n \n\n\n\n BIOCHIMIE, 228: 71-81. JAN 2025.\n \n\n\n\n
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@article{ WOS:001401372400001,\nAuthor = {Mackinnon, Sabrina R. and Zarganes-Tzitzikas, Tryfon and Adams,\n   Cassandra J. and Brennan, Paul E. and Yue, Wyatt W.},\nTitle = {Luminescence-based complementation assay to assess target engagement and\n   cell permeability of glycolate oxidase (HAO1) inhibitors},\nJournal = {BIOCHIMIE},\nYear = {2025},\nVolume = {228},\nPages = {71-81},\nMonth = {JAN},\nDOI = {10.1016/j.biochi.2024.08.011},\nEarlyAccessDate = {DEC 2024},\nISSN = {0300-9084},\nEISSN = {1638-6183},\nORCID-Numbers = {Heaton, Sabrina/0000-0002-6816-244X},\nUnique-ID = {WOS:001401372400001},\n}\n\n
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\n  \n 2024\n \n \n (7)\n \n \n
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\n \n\n \n \n \n \n \n Identification and characterization of human KALRN mRNA and Kalirin protein isoforms.\n \n \n \n\n\n \n Mould, A. W.; Wright, D. J.; Bornemann, K. D.; Hengerer, B.; Pinnock, R.; Drydale, E.; Bancroft, J.; Hall, N. A. L.; von Delft, A.; Brennan, P. E.; Harrison, P. J.; Haerty, W.; and Tunbridge, E. M.\n\n\n \n\n\n\n CEREBRAL CORTEX, 34(12). DEC 4 2024.\n \n\n\n\n
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@article{ WOS:001373177900001,\nAuthor = {Mould, Arne W. and Wright, David J. and Bornemann, Klaus D. and\n   Hengerer, Bastian and Pinnock, Rob and Drydale, Edward and Bancroft,\n   James and Hall, Nicola A. L. and von Delft, Annette and Brennan, Paul E.\n   and Harrison, Paul J. and Haerty, Wilfried and Tunbridge, Elizabeth M.},\nTitle = {Identification and characterization of human KALRN mRNA and\n   Kalirin protein isoforms},\nJournal = {CEREBRAL CORTEX},\nYear = {2024},\nVolume = {34},\nNumber = {12},\nMonth = {DEC 4},\nDOI = {10.1093/cercor/bhae470},\nArticle-Number = {bhae470},\nISSN = {1047-3211},\nEISSN = {1460-2199},\nResearcherID-Numbers = {, Liz/KPB-0164-2024\n   },\nORCID-Numbers = {Mould, Arne/0000-0002-2004-4348},\nUnique-ID = {WOS:001373177900001},\n}\n\n
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\n \n\n \n \n \n \n \n The Chemical Probes Portal-2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research.\n \n \n \n\n\n \n Sanfelice, D.; Antolin, A. A.; Crisp, A.; Chen, Y.; Bellenie, B.; Brennan, P. E.; Edwards, A.; Mueller, S.; Al-Lazikani, B.; and Workman, P.\n\n\n \n\n\n\n NUCLEIC ACIDS RESEARCH, 53(D1): D1663-D1669. NOV 18 2024.\n \n\n\n\n
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@article{ WOS:001358697100001,\nAuthor = {Sanfelice, Domenico and Antolin, Albert A. and Crisp, Alisa and Chen, Yi\n   and Bellenie, Benjamin and Brennan, Paul E. and Edwards, Aled and\n   Mueller, Susanne and Al-Lazikani, Bissan and Workman, Paul},\nTitle = {The Chemical Probes Portal-2024: update on this public resource to\n   support best-practice selection and use of small molecules in biomedical\n   research},\nJournal = {NUCLEIC ACIDS RESEARCH},\nYear = {2024},\nVolume = {53},\nNumber = {D1},\nPages = {D1663-D1669},\nMonth = {NOV 18},\nDOI = {10.1093/nar/gkae1062},\nEarlyAccessDate = {NOV 2024},\nISSN = {0305-1048},\nEISSN = {1362-4962},\nResearcherID-Numbers = {Al-Lazikani, Bissan/AFK-6457-2022\n   Knapp, Stefan/AAG-2347-2019\n   Antolin, Albert/AAZ-8960-2020\n   },\nORCID-Numbers = {Al-Lazikani, Bissan/0000-0003-3367-2519\n   Brennan, Paul/0000-0002-8950-7646\n   Chen, Yi/0009-0009-7409-2140\n   Bellenie, Benjamin/0000-0001-9987-3079\n   Antolin, Albert A./0000-0002-1634-9034\n   Muller-Knapp, Susanne/0000-0003-2402-4157},\nUnique-ID = {WOS:001358697100001},\n}\n\n
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\n \n\n \n \n \n \n \n Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis Non-Muscle Myosin 2A Complex.\n \n \n \n\n\n \n Giroud, C.; Szommer, T.; Coxon, C.; Monteiro, O.; Grimes, T.; Zarganes-Tzitzikas, T.; Christott, T.; Bennett, J.; Buchan, K.; Brennan, P. E.; and Fedorov, O.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 67(21): 18943-18956. OCT 19 2024.\n \n\n\n\n
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@article{ WOS:001340265100001,\nAuthor = {Giroud, Charline and Szommer, Tamas and Coxon, Carmen and Monteiro,\n   Octovia and Grimes, Thomas and Zarganes-Tzitzikas, Tryfon and Christott,\n   Thomas and Bennett, James and Buchan, Karly and Brennan, Paul E. and\n   Fedorov, Oleg},\nTitle = {Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis\n   Non-Muscle Myosin 2A Complex},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2024},\nVolume = {67},\nNumber = {21},\nPages = {18943-18956},\nMonth = {OCT 19},\nDOI = {10.1021/acs.jmedchem.4c01320},\nEarlyAccessDate = {OCT 2024},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Grimes, Thomas/0009-0004-9375-7471\n   Szommer, Tamas/0000-0002-3811-4068\n   Zarganes - Tzitzikas, Tryfon/0000-0001-7323-8587},\nUnique-ID = {WOS:001340265100001},\n}\n\n
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\n \n\n \n \n \n \n \n Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.\n \n \n \n\n\n \n Balikci, E.; Marques, A. M. C.; Bauer, L. G.; Seupel, R.; Bennett, J.; Raux, B.; Buchan, K.; Simelis, K.; Singh, U.; Rogers, C.; Ward, J.; Cheng, C.; Szommer, T.; Schutzenhofer, K.; Elkins, J. M.; Sloman, D. L.; Ahel, I.; Fedorov, O.; Brennan, P. E.; and Huber, K. V. M.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 67(9): 7245-7259. APR 18 2024.\n \n\n\n\n
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@article{ WOS:001227832200001,\nAuthor = {Balikci, Esra and Marques, Anne-Sophie M. C. and Bauer, Ludwig G. and\n   Seupel, Raina and Bennett, James and Raux, Brigitt and Buchan, Karly and\n   Simelis, Klemensas and Singh, Usha and Rogers, Catherine and Ward,\n   Jennifer and Cheng, Carol and Szommer, Tamas and Schutzenhofer, Kira and\n   Elkins, Jonathan M. and Sloman, David L. and Ahel, Ivan and Fedorov,\n   Oleg and Brennan, Paul E. and Huber, Kilian V. M.},\nTitle = {Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors\n   Leads to Discovery of a Dual NUDT5/14 Antagonist},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2024},\nVolume = {67},\nNumber = {9},\nPages = {7245-7259},\nMonth = {APR 18},\nDOI = {10.1021/acs.jmedchem.4c00072},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Huber, Kilian/L-6921-2015\n   RAUX, BRIGITT/H-7391-2018\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Bauer, Ludwig G./0000-0002-2235-3945\n   Szommer, Tamas/0000-0002-3811-4068\n   Marques, Anne-Sophie M. C./0009-0005-5726-508X\n   Balikci, Esra/0009-0000-9160-5790\n   Bennett, James/0000-0003-1396-8400\n   Simelis, Klemensas/0000-0001-7578-4370},\nUnique-ID = {WOS:001227832200001},\n}\n\n
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\n \n\n \n \n \n \n \n Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.\n \n \n \n\n\n \n Bradshaw, W. J.; Kennedy, E. C.; Moreira, T.; Smith, L. A.; Chalk, R.; Katis, V. L.; Benesch, J. L. P.; Brennan, P. E.; Murphy, E. J.; and Gileadi, O.\n\n\n \n\n\n\n STRUCTURE, 32(4). APR 4 2024.\n \n\n\n\n
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@article{ WOS:001226281900001,\nAuthor = {Bradshaw, William J. and Kennedy, Emma C. and Moreira, Tiago and Smith,\n   Luke A. and Chalk, Rod and Katis, Vittorio L. and Benesch, Justin L. P.\n   and Brennan, Paul E. and Murphy, Emma J. and Gileadi, Opher},\nTitle = {Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1\n   and SHIP2},\nJournal = {STRUCTURE},\nYear = {2024},\nVolume = {32},\nNumber = {4},\nMonth = {APR 4},\nDOI = {10.1016/j.str.2024.01.005},\nEarlyAccessDate = {APR 2024},\nISSN = {0969-2126},\nEISSN = {1878-4186},\nResearcherID-Numbers = {Benesch, Justin/A-4250-2008\n   Smith, Luke/ITV-3497-2023\n   Gileadi, Opher/F-1105-2013\n   Bradshaw, William/HJP-5994-2023\n   },\nORCID-Numbers = {Bradshaw, William/0000-0002-7985-9752\n   Murphy, Emma/0000-0003-4551-8068},\nUnique-ID = {WOS:001226281900001},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.\n \n \n \n\n\n \n Xiong, Y.; Greschik, H.; Johansson, C.; Seifert, L.; Gamble, V.; Park, K.; Fagan, V.; Li, F.; Chau, I.; Vedadi, M.; Arrowsmith, C. H.; Brennan, P.; Fedorov, O.; Jung, M.; Farnie, G.; Liu, J.; Oppermann, U.; Schuele, R.; and Jin, J.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 67(7): 5837-5853. MAR 27 2024.\n \n\n\n\n
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@article{ WOS:001192402300001,\nAuthor = {Xiong, Yan and Greschik, Holger and Johansson, Catrine and Seifert,\n   Ludwig and Gamble, Vicki and Park, Kwang-su and Fagan, Vincent and Li,\n   Fengling and Chau, Irene and Vedadi, Masoud and Arrowsmith, Cheryl H.\n   and Brennan, Paul and Fedorov, Oleg and Jung, Manfred and Farnie,\n   Gillian and Liu, Jing and Oppermann, Udo and Schuele, Roland and Jin,\n   Jian},\nTitle = {Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2024},\nVolume = {67},\nNumber = {7},\nPages = {5837-5853},\nMonth = {MAR 27},\nDOI = {10.1021/acs.jmedchem.4c00121},\nEarlyAccessDate = {MAR 2024},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Schüle, Rebecca/B-5763-2019\n   Park, Kwang-Su/JRX-7211-2023\n   farnie, gillian/GLT-8777-2022\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Park, Kwangsu/0000-0002-1910-3937},\nUnique-ID = {WOS:001192402300001},\n}\n\n
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\n \n\n \n \n \n \n \n Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.\n \n \n \n\n\n \n Bashore, F. M.; Katis, V. L.; Du, Y.; Sikdar, A.; Wang, D.; Bradshaw, W. J.; Rygiel, K. A.; Leisner, T. M.; Chalk, R.; Mishra, S.; Williams, C. A.; Gileadi, O.; Brennan, P. E.; Wiley, J. C.; Gockley, J.; Cary, G. A.; Carter, G. W.; Young, J. E.; Pearce, K. H.; Fu, H.; Axtman, A. D.; and Ctr, E. S. S. A.\n\n\n \n\n\n\n PLOS ONE, 19(2). FEB 15 2024.\n \n\n\n\n
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@article{ WOS:001164173200053,\nAuthor = {Bashore, Frances M. and Katis, Vittorio L. and Du, Yuhong and Sikdar,\n   Arunima and Wang, Dongxue and Bradshaw, William J. and Rygiel, Karolina\n   A. and Leisner, Tina M. and Chalk, Rod and Mishra, Swati and Williams,\n   C. Andrew and Gileadi, Opher and Brennan, Paul E. and Wiley, Jesse C.\n   and Gockley, Jake and Cary, Gregory A. and Carter, Gregory W. and Young,\n   Jessica E. and Pearce, Kenneth H. and Fu, Haian and Axtman, Alison D.\n   and Emory Sage SGCTREAT AD Ctr},\nTitle = {Characterization of covalent inhibitors that disrupt the interaction\n   between the tandem SH2 domains of SYK and FCER1G phospho-ITAM},\nJournal = {PLOS ONE},\nYear = {2024},\nVolume = {19},\nNumber = {2},\nMonth = {FEB 15},\nDOI = {10.1371/journal.pone.0293548},\nArticle-Number = {e0293548},\nISSN = {1932-6203},\nResearcherID-Numbers = {Fowler, Vance/LSL-9530-2024\n   Sikdar, Arunima/GMX-3138-2022\n   Bradshaw, William/HJP-5994-2023\n   Gileadi, Opher/F-1105-2013\n   },\nORCID-Numbers = {Gileadi, Opher/0000-0001-6886-898X\n   Bashore, Frances/0000-0003-4241-9873\n   Bradshaw, William/0000-0002-7985-9752\n   Sikdar, Arunima/0000-0002-0132-8513\n   Gockley, Jake/0000-0001-7993-5308\n   Katis, Vittorio/0000-0002-0696-8042},\nUnique-ID = {WOS:001164173200053},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.\n \n \n \n\n\n \n Du, Y.; Bradshaw, W. J.; Leisner, T. M.; Annor-Gyamfi, J. K.; Qian, K.; Bashore, F. M.; Sikdar, A.; Nwogbo, F. O.; Ivanov, A. A.; Frye, V; Gileadi, O.; Brennan, P. E.; Levey, A. I.; Axtman, A. D.; Pearce, K. H.; Fu, H.; Katis, V. L.; and Ctr, E. S. S. T. A.\n\n\n \n\n\n\n JOURNAL OF BIOLOGICAL CHEMISTRY, 299(12). DEC 2023.\n \n\n\n\n
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@article{ WOS:001166193800001,\nAuthor = {Du, Yuhong and Bradshaw, William J. and Leisner, Tina M. and\n   Annor-Gyamfi, Joel K. and Qian, Kun and Bashore, Frances M. and Sikdar,\n   Arunima and Nwogbo, Felix O. and Ivanov, Andrey A. and Frye, V, Stephen\n   and Gileadi, Opher and Brennan, Paul E. and Levey, Allan I. and Axtman,\n   Alison D. and Pearce, Kenneth H. and Fu, Haian and Katis, Vittorio L.\n   and Emory Sage SGC TREAT AD Ctr},\nTitle = {Discovery of FERM domain protein-protein interaction inhibitors for MSN\n   and CD44 as a potential therapeutic approach for Alzheimer's disease},\nJournal = {JOURNAL OF BIOLOGICAL CHEMISTRY},\nYear = {2023},\nVolume = {299},\nNumber = {12},\nMonth = {DEC},\nDOI = {10.1016/j.jbc.2023.105382},\nEarlyAccessDate = {NOV 2023},\nArticle-Number = {105382},\nEISSN = {1083-351X},\nResearcherID-Numbers = {Bradshaw, William/HJP-5994-2023\n   Sikdar, Arunima/JXN-9515-2024\n   Levey, Allan/F-2104-2011\n   Gileadi, Opher/F-1105-2013\n   },\nORCID-Numbers = {Sikdar, Arunima/0000-0002-0132-8513\n   Levey, Allan/0000-0002-3153-502X\n   Gileadi, Opher/0000-0001-6886-898X\n   Qian, Kun/0000-0003-1132-2374\n   Bashore, Frances/0000-0003-4241-9873\n   Bradshaw, William/0000-0002-7985-9752\n   Leisner, Tina/0000-0002-8682-9260},\nUnique-ID = {WOS:001166193800001},\n}\n\n
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\n \n\n \n \n \n \n \n The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system.\n \n \n \n\n\n \n Fazazi, M. R.; Ruda, G. F.; Brennan, P. E.; and Rangachari, M.\n\n\n \n\n\n\n BRAIN RESEARCH BULLETIN, 202. OCT 1 2023.\n \n\n\n\n
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@article{ WOS:001072451600001,\nAuthor = {Fazazi, Mohamed Reda and Ruda, Gian Filippo and Brennan, Paul E. and\n   Rangachari, Manu},\nTitle = {The X-linked histone demethylases KDM5C and KDM6A as regulators of T\n   cell-driven autoimmunity in the central nervous system},\nJournal = {BRAIN RESEARCH BULLETIN},\nYear = {2023},\nVolume = {202},\nMonth = {OCT 1},\nDOI = {10.1016/j.brainresbull.2023.110748},\nEarlyAccessDate = {SEP 2023},\nArticle-Number = {110748},\nISSN = {0361-9230},\nEISSN = {1873-2747},\nUnique-ID = {WOS:001072451600001},\n}\n\n
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\n \n\n \n \n \n \n \n Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides.\n \n \n \n\n\n \n O'Brien, D. P.; Jones, H. B. L.; Guenther, F.; Murphy, E. J.; England, K. S.; Vendrell, I.; Anderson, M.; Brennan, P. E.; Davis, J. B.; Turnbull, A. P.; Kessler, B. M.; and Pinto-Fernandez, A.\n\n\n \n\n\n\n MOLECULAR & CELLULAR PROTEOMICS, 22(8). AUG 2023.\n \n\n\n\n
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@article{ WOS:001162917300001,\nAuthor = {O'Brien, Darragh P. and Jones, Hannah B. L. and Guenther, Franziska and\n   Murphy, Emma J. and England, Katherine S. and Vendrell, Iolanda and\n   Anderson, Malcolm and Brennan, Paul E. and Davis, John B. and Turnbull,\n   Andrew P. and Kessler, Benedikt M. and Pinto-Fernandez, Adan},\nTitle = {Structural Premise of Selective Deubiquitinase USP30 Inhibition by\n   Small-Molecule Benzosulfonamides},\nJournal = {MOLECULAR \\& CELLULAR PROTEOMICS},\nYear = {2023},\nVolume = {22},\nNumber = {8},\nMonth = {AUG},\nDOI = {10.1016/j.mcpro.2023.100609},\nArticle-Number = {100609},\nEISSN = {1535-9484},\nResearcherID-Numbers = {Kessler, Benedikt/JGC-6978-2023\n   },\nORCID-Numbers = {Kessler, Benedikt/0000-0002-8160-2446\n   Jones, Hannah/0000-0002-7834-0625\n   Guenther, Franziska/0000-0002-7920-7877\n   England, Katherine/0000-0002-4921-7505\n   O'Brien, Darragh P./0000-0003-4924-7795\n   Murphy, Emma/0000-0003-4551-8068},\nUnique-ID = {WOS:001162917300001},\n}\n\n
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\n \n\n \n \n \n \n \n Open drug discovery in Alzheimer's disease.\n \n \n \n\n\n \n Axtman, A. D. E.; Brennan, P. E.; Frappier-Brinton, T.; Betarbet, R. W.; Carter, G. W.; Fu, H.; Gileadi, O. K.; Greenwood, A. K.; Leal, K. M.; Longo, F. M. M.; Mangravite, L. M. M.; Edwards, A. M. I.; Levey, I; and Ctr, E. T.\n\n\n \n\n\n\n ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS, 9(2). APR 2023.\n \n\n\n\n
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@article{ WOS:000989844300001,\nAuthor = {Axtman, Alison. D. E. and Brennan, Paul. E. and Frappier-Brinton,\n   Tristan and Betarbet, Ranjita W. and Carter, Gregory. W. and Fu, Haian\n   and Gileadi, Opher K. and Greenwood, Anna. K. and Leal, Karina M. and\n   Longo, Frank. M. M. and Mangravite, Lara. M. M. and Edwards, Aled. M. I.\n   and Levey, I, Allan. and Emory-Sage-SGC TREAT-AD Ctr},\nTitle = {Open drug discovery in Alzheimer's disease},\nJournal = {ALZHEIMERS \\& DEMENTIA-TRANSLATIONAL RESEARCH \\& CLINICAL INTERVENTIONS},\nYear = {2023},\nVolume = {9},\nNumber = {2},\nMonth = {APR},\nDOI = {10.1002/trc2.12394},\nArticle-Number = {e12394},\nEISSN = {2352-8737},\nResearcherID-Numbers = {Levey, Allan/F-2104-2011},\nORCID-Numbers = {Levey, Allan/0000-0002-3153-502X},\nUnique-ID = {WOS:000989844300001},\n}\n\n
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\n \n\n \n \n \n \n \n Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity.\n \n \n \n\n\n \n Fowkes, M. M.; Troeberg, L.; Brennan, P. E.; Vincent, T. L.; Meldal, M.; and Lim, N. H.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 66(5): 3522-3539. MAR 9 2023.\n \n\n\n\n
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@article{ WOS:000936765300001,\nAuthor = {Fowkes, Milan M. and Troeberg, Linda and Brennan, Paul E. and Vincent,\n   Tonia L. and Meldal, Morten and Lim, Ngee H.},\nTitle = {Development of Selective ADAMTS-5 Peptide Substrates to Monitor\n   Proteinase Activity},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2023},\nVolume = {66},\nNumber = {5},\nPages = {3522-3539},\nMonth = {MAR 9},\nDOI = {10.1021/acs.jmedchem.2c02090},\nEarlyAccessDate = {FEB 2023},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Lim, Ngee/B-4226-2011\n   Fowkes, Milan/J-9730-2019\n   Meldal, Morten/ISU-3466-2023\n   Meldal, Morten/B-7626-2016\n   },\nORCID-Numbers = {Lim, Ngee Han/0000-0002-8520-7857\n   Meldal, Morten/0000-0001-6114-9018\n   Fowkes, Milan Mrazek/0000-0003-3373-7714\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000936765300001},\n}\n\n
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\n  \n 2022\n \n \n (5)\n \n \n
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\n \n\n \n \n \n \n \n Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane.\n \n \n \n\n\n \n Frank, N.; Nugent, J.; Shire, B. R.; Pickford, H. D.; Rabe, P.; Sterling, A. J.; Zarganes-Tzitzikas, T.; Grimes, T.; Thompson, A. L.; Smith, R. C.; Schofield, C. J.; Brennan, P. E.; Duarte, F.; and Anderson, E. A.\n\n\n \n\n\n\n NATURE, 611(7937): 721+. NOV 24 2022.\n \n\n\n\n
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@article{ WOS:000869346300001,\nAuthor = {Frank, Nils and Nugent, Jeremy and Shire, Bethany R. and Pickford,\n   Helena D. and Rabe, Patrick and Sterling, Alistair J. and\n   Zarganes-Tzitzikas, Tryfon and Grimes, Thomas and Thompson, Amber L. and\n   Smith, Russell C. and Schofield, Christopher J. and Brennan, Paul E. and\n   Duarte, Fernanda and Anderson, Edward A.},\nTitle = {Synthesis of meta-substituted arene bioisosteres from\n   {[}3.1.1]propellane},\nJournal = {NATURE},\nYear = {2022},\nVolume = {611},\nNumber = {7937},\nPages = {721+},\nMonth = {NOV 24},\nDOI = {10.1038/s41586-022-05290-z},\nEarlyAccessDate = {SEP 2022},\nISSN = {0028-0836},\nEISSN = {1476-4687},\nResearcherID-Numbers = {Duarte, Fernanda/I-5796-2019\n   Sterling, Alistair/AGH-4123-2022\n   Pickford, Helena/HKM-8076-2023\n   },\nORCID-Numbers = {Schofield, Chris/0009-0008-4988-0199\n   Smith, Russell/0009-0001-8657-0180\n   Pickford, Helena/0000-0003-0941-7585\n   Zarganes - Tzitzikas, Tryfon/0000-0001-7323-8587\n   Nugent, Jeremy/0000-0001-7204-6161\n   Rabe, Patrick/0000-0002-3448-9559\n   Grimes, Thomas/0009-0004-9375-7471\n   Frank, Nils/0000-0002-8512-6598},\nUnique-ID = {WOS:000869346300001},\n}\n\n
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\n \n\n \n \n \n \n \n Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening.\n \n \n \n\n\n \n Mackinnon, S. R.; Bezerra, G. A.; Krojer, T.; Szommer, T.; von Delft, F.; Brennan, P. E.; and Yue, W. W.\n\n\n \n\n\n\n FRONTIERS IN CHEMISTRY, 10. MAY 4 2022.\n \n\n\n\n
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@article{ WOS:000797694200001,\nAuthor = {Mackinnon, Sabrina R. and Bezerra, Gustavo A. and Krojer, Tobias and\n   Szommer, Tamas and von Delft, Frank and Brennan, Paul E. and Yue, Wyatt\n   W.},\nTitle = {Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed\n   by Crystallography-Based Fragment Screening},\nJournal = {FRONTIERS IN CHEMISTRY},\nYear = {2022},\nVolume = {10},\nMonth = {MAY 4},\nDOI = {10.3389/fchem.2022.844598},\nArticle-Number = {844598},\nISSN = {2296-2646},\nResearcherID-Numbers = {Krojer, Tobias/ABE-3829-2021\n   },\nORCID-Numbers = {Heaton, Sabrina/0000-0002-6816-244X\n   Krojer, Tobias/0000-0003-0661-0814\n   Yue, Wyatt/0000-0001-6959-6007\n   Szommer, Tamas/0000-0002-3811-4068},\nUnique-ID = {WOS:000797694200001},\n}\n\n
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\n \n\n \n \n \n \n \n Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators.\n \n \n \n\n\n \n Rothweiler, E. M.; Brennan, P. E.; and Huber, K. V. M.\n\n\n \n\n\n\n BIOLOGICAL CHEMISTRY, 403(4): 391-402. MAR 28 2022.\n \n\n\n\n
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@article{ WOS:000758591300001,\nAuthor = {Rothweiler, Elisabeth M. and Brennan, Paul E. and Huber, Kilian V. M.},\nTitle = {Covalent fragment-based ligand screening approaches for identification\n   of novel ubiquitin proteasome system modulators},\nJournal = {BIOLOGICAL CHEMISTRY},\nYear = {2022},\nVolume = {403},\nNumber = {4},\nPages = {391-402},\nMonth = {MAR 28},\nDOI = {10.1515/hsz-2021-0396},\nEarlyAccessDate = {FEB 2022},\nISSN = {1431-6730},\nEISSN = {1437-4315},\nResearcherID-Numbers = {Huber, Kilian/L-6921-2015},\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Rothweiler, Elisabeth Mira/0000-0003-3303-2044\n   Huber, Kilian/0000-0002-1103-5300},\nUnique-ID = {WOS:000758591300001},\n}\n\n
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\n \n\n \n \n \n \n \n Kalirin as a Novel Treatment Target for Cognitive Dysfunction in Schizophrenia.\n \n \n \n\n\n \n Mould, A. W.; Al-Juffali, N.; von Delft, A.; Brennan, P. E.; and Tunbridge, E. M.\n\n\n \n\n\n\n CNS DRUGS, 36(1): 1-16. JAN 2022.\n \n\n\n\n
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@article{ WOS:000733429800001,\nAuthor = {Mould, Arne W. and Al-Juffali, Noura and von Delft, Annette and Brennan,\n   Paul E. and Tunbridge, Elizabeth M.},\nTitle = {Kalirin as a Novel Treatment Target for Cognitive Dysfunction in\n   Schizophrenia},\nJournal = {CNS DRUGS},\nYear = {2022},\nVolume = {36},\nNumber = {1},\nPages = {1-16},\nMonth = {JAN},\nDOI = {10.1007/s40263-021-00884-z},\nEarlyAccessDate = {DEC 2021},\nISSN = {1172-7047},\nEISSN = {1179-1934},\nResearcherID-Numbers = {, Liz/KPB-0164-2024\n   },\nORCID-Numbers = {Al-Juffali, Noura/0000-0001-9190-6729\n   von Delft, Annette/0000-0002-7699-8140\n   Brennan, Paul/0000-0002-8950-7646\n   Tunbridge, Elizabeth/0000-0002-2966-2281\n   Mould, Arne/0000-0002-2004-4348},\nUnique-ID = {WOS:000733429800001},\n}\n\n
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\n \n\n \n \n \n \n \n Target 2035-update on the quest for a probe for every protein.\n \n \n \n\n\n \n Mueller, S.; Ackloo, S.; Al Chawaf, A.; Al-Lazikani, B.; Antolin, A.; Baell, J. B.; Beck, H.; Beedie, S.; Betz, U. A. K.; Bezerra, G. A.; Brennan, P. E.; Brown, D.; Brown, P. J.; Bullock, A. N.; Carter, A. J.; Chaikuad, A.; Chaineau, M.; Ciulli, A.; Collins, I.; Dreher, J.; Drewry, D.; Edfeldt, K.; Edwards, A. M.; Egner, U.; Frye, V; Fuchs, S. M.; Hall, M. D.; Hartung, V; Hillisch, A.; Hitchcock, S. H.; Homan, E.; Kannan, N.; Kiefer, J. R.; Knapp, S.; Kostic, M.; Kubicek, S.; Leach, A. R.; Lindemann, S.; Marsden, B. D.; Matsui, H.; Meier, J. L.; Merk, D.; Michel, M.; Morgan, M. R.; Mueller-Fahrnow, A.; Owen, D. R.; Perry, B. G.; Rosenberg, S. H.; Saikatendu, K. S.; Schapira, M.; Scholten, C.; Sharma, S.; Simeonov, A.; Sundstrom, M.; Superti-Furga, G.; Todd, M. H.; Tredup, C.; Vedadi, M.; von Delft, F.; Willson, T. M.; Winter, G. E.; Workman, P.; and Arrowsmith, C. H.\n\n\n \n\n\n\n RSC MEDICINAL CHEMISTRY, 13(1): 13-21. JAN 27 2022.\n \n\n\n\n
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@article{ WOS:000725661300001,\nAuthor = {Mueller, Susanne and Ackloo, Suzanne and Al Chawaf, Arij and\n   Al-Lazikani, Bissan and Antolin, Albert and Baell, Jonathan B. and Beck,\n   Hartmut and Beedie, Shaunna and Betz, Ulrich A. K. and Bezerra, Gustavo\n   Arruda and Brennan, Paul E. and Brown, David and Brown, Peter J. and\n   Bullock, Alex N. and Carter, Adrian J. and Chaikuad, Apirat and\n   Chaineau, Mathilde and Ciulli, Alessio and Collins, Ian and Dreher, Jan\n   and Drewry, David and Edfeldt, Kristina and Edwards, Aled M. and Egner,\n   Ursula and Frye, V, Stephen and Fuchs, Stephen M. and Hall, Matthew D.\n   and Hartung, V, Ingo and Hillisch, Alexander and Hitchcock, Stephen H.\n   and Homan, Evert and Kannan, Natarajan and Kiefer, James R. and Knapp,\n   Stefan and Kostic, Milka and Kubicek, Stefan and Leach, Andrew R. and\n   Lindemann, Sven and Marsden, Brian D. and Matsui, Hisanori and Meier,\n   Jordan L. and Merk, Daniel and Michel, Maurice and Morgan, Maxwell R.\n   and Mueller-Fahrnow, Anke and Owen, Dafydd R. and Perry, Benjamin G. and\n   Rosenberg, Saul H. and Saikatendu, Kumar Singh and Schapira, Matthieu\n   and Scholten, Cora and Sharma, Sujata and Simeonov, Anton and Sundstrom,\n   Michael and Superti-Furga, Giulio and Todd, Matthew H. and Tredup,\n   Claudia and Vedadi, Masoud and von Delft, Frank and Willson, Timothy M.\n   and Winter, Georg E. and Workman, Paul and Arrowsmith, Cheryl H.},\nTitle = {Target 2035-update on the quest for a probe for every protein},\nJournal = {RSC MEDICINAL CHEMISTRY},\nYear = {2022},\nVolume = {13},\nNumber = {1},\nPages = {13-21},\nMonth = {JAN 27},\nDOI = {10.1039/d1md00228g},\nEarlyAccessDate = {DEC 2021},\nEISSN = {2632-8682},\nResearcherID-Numbers = {Meier, Jordan/N-2608-2014\n   Knapp, Stefan/AAG-2347-2019\n   Al-Lazikani, Bissan/AFK-6457-2022\n   Michel, Maurice/AAM-8825-2021\n   Kostic, Milka/AAC-3213-2020\n   Fuchs, Stephen/I-7251-2012\n   Ciulli, Alessio/A-6279-2011\n   Sharma, Sachin/Q-5203-2019\n   Hall, Matthew/B-2132-2010\n   Superti-Furga, Giulio/AAE-5681-2019\n   Antolin, Albert/AAZ-8960-2020\n   Baell, Jonathan/E-5844-2017\n   Todd, Matthew/S-2678-2018\n   feinstein, doug/M-9414-2019\n   Kubicek, Stefan/C-2089-2017\n   Leach, Andrew/N-9949-2017\n   },\nORCID-Numbers = {Kubicek, Stefan/0000-0003-0855-8343\n   Al-Lazikani, Bissan/0000-0003-3367-2519\n   Edwards, Aled/0000-0002-4782-6016\n   Leach, Andrew/0000-0001-8178-0253\n   Homan, Evert/0000-0002-9057-1848\n   Willson, Timothy/0000-0003-4181-8223\n   Edfeldt, Kristina/0000-0002-0550-1133\n   Chaineau, Mathilde/0000-0002-9705-0754\n   Matsui, Hisanori/0000-0002-4068-342X\n   Morgan, Maxwell/0000-0002-4784-6113\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Michel, Maurice/0000-0003-3261-2493\n   Lindemann, Sven/0000-0002-0885-6175\n   Ackloo, Suzanne/0000-0002-9696-1839\n   Knapp, Stefan/0000-0001-5995-6494},\nUnique-ID = {WOS:000725661300001},\n}\n\n
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\n  \n 2021\n \n \n (8)\n \n \n
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\n \n\n \n \n \n \n \n A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation (vol 11, 15319, 2021).\n \n \n \n\n\n \n Nizami, S.; Millar, V.; Arunasalam, K.; Zarganes-Tzitzikas, T.; Brough, D.; Tresadern, G.; Brennan, P. E.; Davis, J. B.; Ebner, D.; and Di Daniel, E.\n\n\n \n\n\n\n SCIENTIFIC REPORTS, 11(1). OCT 11 2021.\n \n\n\n\n
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@article{ WOS:000706395800063,\nAuthor = {Nizami, Sohaib and Millar, Val and Arunasalam, Kanisa and\n   Zarganes-Tzitzikas, Tryfon and Brough, David and Tresadern, Gary and\n   Brennan, Paul E. and Davis, John B. and Ebner, Daniel and Di Daniel,\n   Elena},\nTitle = {A phenotypic high-content, high-throughput screen identifies inhibitors\n   of NLRP3 inflammasome activation (vol 11, 15319, 2021)},\nJournal = {SCIENTIFIC REPORTS},\nYear = {2021},\nVolume = {11},\nNumber = {1},\nMonth = {OCT 11},\nDOI = {10.1038/s41598-021-00202-z},\nArticle-Number = {20529},\nISSN = {2045-2322},\nORCID-Numbers = {Zarganes - Tzitzikas, Tryfon/0000-0001-7323-8587\n   Ebner, Daniel/0000-0002-6495-7026\n   , Elena/0000-0002-0535-2123},\nUnique-ID = {WOS:000706395800063},\n}\n\n
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\n \n\n \n \n \n \n \n A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation.\n \n \n \n\n\n \n Nizami, S.; Millar, V.; Arunasalam, K.; Zarganes-Tzitzikas, T.; Brough, D.; Tresadern, G.; Brennan, P. E.; Davis, J. B.; Ebner, D.; and Di Daniel, E.\n\n\n \n\n\n\n SCIENTIFIC REPORTS, 11(1). JUL 28 2021.\n \n\n\n\n
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@article{ WOS:000683351600013,\nAuthor = {Nizami, Sohaib and Millar, Val and Arunasalam, Kanisa and\n   Zarganes-Tzitzikas, Tryfon and Brough, David and Tresadern, Gary and\n   Brennan, Paul E. and Davis, John B. and Ebner, Daniel and Di Daniel,\n   Elena},\nTitle = {A phenotypic high-content, high-throughput screen identifies inhibitors\n   of NLRP3 inflammasome activation},\nJournal = {SCIENTIFIC REPORTS},\nYear = {2021},\nVolume = {11},\nNumber = {1},\nMonth = {JUL 28},\nDOI = {10.1038/s41598-021-94850-w},\nArticle-Number = {15319},\nISSN = {2045-2322},\nORCID-Numbers = {Ebner, Daniel/0000-0002-6495-7026\n   Zarganes - Tzitzikas, Tryfon/0000-0001-7323-8587\n   , Elena/0000-0002-0535-2123},\nUnique-ID = {WOS:000683351600013},\n}\n\n
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\n \n\n \n \n \n \n \n The structural basis of fatty acid elongation by the ELOVL elongases.\n \n \n \n\n\n \n Nie, L.; Pascoa, T. C.; Pike, A. C. W.; Bushell, S. R.; Quigley, A.; Ruda, G. F.; Chu, A.; Cole, V.; Speedman, D.; Moreira, T.; Shrestha, L.; Mukhopadhyay, S. M. M.; Burgess-Brown, N. A.; Love, J. D.; Brennan, P. E.; and Carpenter, E. P.\n\n\n \n\n\n\n NATURE STRUCTURAL & MOLECULAR BIOLOGY, 28(6): 512+. JUN 2021.\n \n\n\n\n
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@article{ WOS:000660587400010,\nAuthor = {Nie, Laiyin and Pascoa, Tomas C. and Pike, Ashley C. W. and Bushell,\n   Simon R. and Quigley, Andrew and Ruda, Gian Filippo and Chu, Amy and\n   Cole, Victoria and Speedman, David and Moreira, Tiago and Shrestha,\n   Leela and Mukhopadhyay, Shubhashish M. M. and Burgess-Brown, Nicola A.\n   and Love, James D. and Brennan, Paul E. and Carpenter, Elisabeth P.},\nTitle = {The structural basis of fatty acid elongation by the ELOVL elongases},\nJournal = {NATURE STRUCTURAL \\& MOLECULAR BIOLOGY},\nYear = {2021},\nVolume = {28},\nNumber = {6},\nPages = {512+},\nMonth = {JUN},\nDOI = {10.1038/s41594-021-00605-6},\nISSN = {1545-9993},\nEISSN = {1545-9985},\nResearcherID-Numbers = {Moreira, Tiago/I-4266-2016\n   },\nORCID-Numbers = {Pascoa, Tomas/0000-0003-3375-4207\n   Quigley, Andrew/0000-0002-5022-9845\n   Speedman, David/0009-0002-5242-4107\n   Pike, Ashley/0000-0001-9661-2607},\nUnique-ID = {WOS:000660587400010},\n}\n\n
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\n \n\n \n \n \n \n \n Chemogenomics for drug discovery: clinical molecules from open access chemical probes.\n \n \n \n\n\n \n Quinlan, R. B. A.; and Brennan, P. E.\n\n\n \n\n\n\n RSC CHEMICAL BIOLOGY, 2(3): 759-795. JUN 1 2021.\n \n\n\n\n
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@article{ WOS:000636484900001,\nAuthor = {Quinlan, Robert B. A. and Brennan, Paul E.},\nTitle = {Chemogenomics for drug discovery: clinical molecules from open access\n   chemical probes},\nJournal = {RSC CHEMICAL BIOLOGY},\nYear = {2021},\nVolume = {2},\nNumber = {3},\nPages = {759-795},\nMonth = {JUN 1},\nDOI = {10.1039/d1cb00016k},\nEarlyAccessDate = {MAR 2021},\nISSN = {2633-0679},\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Quinlan, Robert/0000-0002-7257-8878},\nUnique-ID = {WOS:000636484900001},\n}\n\n
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\n \n\n \n \n \n \n \n Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.\n \n \n \n\n\n \n Mackinnon, S. R.; Krojer, T.; Foster, W. R.; Diaz-Saez, L.; Tang, M.; Huber, K. V. M.; von Delft, F.; Lai, K.; Brennan, P. E.; Bezerra, G. A.; and Yue, W. W.\n\n\n \n\n\n\n ACS CHEMICAL BIOLOGY, 16(4): 586-595. APR 16 2021.\n \n\n\n\n
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@article{ WOS:000641310300004,\nAuthor = {Mackinnon, Sabrina R. and Krojer, Tobias and Foster, William R. and\n   Diaz-Saez, Laura and Tang, Manshu and Huber, Kilian V. M. and von Delft,\n   Frank and Lai, Kent and Brennan, Paul E. and Bezerra, Gustavo Arruda and\n   Yue, Wyatt W.},\nTitle = {Fragment Screening Reveals Starting Points for Rational Design of\n   Galactokinase 1 Inhibitors to Treat Classic Galactosemia},\nJournal = {ACS CHEMICAL BIOLOGY},\nYear = {2021},\nVolume = {16},\nNumber = {4},\nPages = {586-595},\nMonth = {APR 16},\nDOI = {10.1021/acschembio.0c00498},\nEarlyAccessDate = {MAR 2021},\nISSN = {1554-8929},\nEISSN = {1554-8937},\nResearcherID-Numbers = {Krojer, Tobias/ABE-3829-2021\n   Huber, Kilian/L-6921-2015\n   },\nORCID-Numbers = {Heaton, Sabrina/0000-0002-6816-244X\n   Yue, Wyatt/0000-0001-6959-6007\n   Krojer, Tobias/0000-0003-0661-0814\n   Huber, Kilian/0000-0002-1103-5300\n   von Delft, Frank/0000-0003-0378-0017\n   Brennan, Paul/0000-0002-8950-7646\n   Diaz Saez, Laura/0000-0001-5814-7150},\nUnique-ID = {WOS:000641310300004},\n}\n\n
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\n \n\n \n \n \n \n \n Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity.\n \n \n \n\n\n \n Doss, P. M. I. A.; Umair, M.; Baillargeon, J.; Fazazi, R.; Fudge, N.; Akbar, I.; Yeola, A. P.; Williams, J. B.; Leclercq, M.; Joly-Beauparlant, C.; Beauchemin, P.; Ruda, G. F.; Alpaugh, M.; Anderson, A. C.; Brennan, P. E.; Droit, A.; Lassmann, H.; Moore, C. S.; and Rangachari, M.\n\n\n \n\n\n\n CELL REPORTS, 34(10). MAR 9 2021.\n \n\n\n\n
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@article{ WOS:000627660900020,\nAuthor = {Doss, Prenitha Mercy Ignatius Arokia and Umair, Muhammad and\n   Baillargeon, Joanie and Fazazi, Reda and Fudge, Neva and Akbar, Irshad\n   and Yeola, Asmita Pradeep and Williams, John B. and Leclercq, Mickael\n   and Joly-Beauparlant, Charles and Beauchemin, Philippe and Ruda, Gian\n   Filipo and Alpaugh, Melanie and Anderson, Ana C. and Brennan, Paul E.\n   and Droit, Arnaud and Lassmann, Hans and Moore, Craig S. and Rangachari,\n   Manu},\nTitle = {Male sex chromosomal complement exacerbates the pathogenicity of Th17\n   cells in a chronic model of central nervous system autoimmunity},\nJournal = {CELL REPORTS},\nYear = {2021},\nVolume = {34},\nNumber = {10},\nMonth = {MAR 9},\nDOI = {10.1016/j.celrep.2021.108833},\nEarlyAccessDate = {MAR 2021},\nArticle-Number = {108833},\nISSN = {2211-1247},\nResearcherID-Numbers = {Moore, Craig/AGF-9555-2022\n   Alpaugh, Melanie/JVO-1022-2024\n   Leclercq, Mickael/K-5246-2019\n   Anderson, Ana/ABD-6829-2021\n   Droit, Arnaud/AGZ-6283-2022\n   Lassmann, Hans/Z-2269-2019\n   Moore, Craig/I-9205-2014\n   },\nORCID-Numbers = {Moore, Craig/0000-0003-3333-435X\n   Fazazi, Reda/0000-0002-9139-1048\n   Ignatius Arokia Doss, Prenitha Mercy/0009-0002-9561-8008},\nUnique-ID = {WOS:000627660900020},\n}\n\n
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\n \n\n \n \n \n \n \n The Discovery and Utility of Chemical Probes in Target Discovery Preface.\n \n \n \n\n\n \n Brennan, P.; and Rodriguez, S. V.\n\n\n \n\n\n\n In Brennan, P; and Rodriguez, S., editor(s), DISCOVERY AND UTILITY OF CHEMICAL PROBES IN TARGET DISCOVERY, volume 16, of Chemical Biology, pages V-VII. 2021.\n \n\n\n\n
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@incollection{ WOS:000746504500012,\nAuthor = {Brennan, Paul and Rodriguez, Saleta Vazquez},\nEditor = {Brennan, P and Rodriguez, SV},\nTitle = {The Discovery and Utility of Chemical Probes in Target Discovery\n   Preface},\nBooktitle = {DISCOVERY AND UTILITY OF CHEMICAL PROBES IN TARGET DISCOVERY},\nSeries = {Chemical Biology},\nYear = {2021},\nVolume = {16},\nPages = {V-VII},\nISSN = {2055-1975},\nISBN = {978-1-83916-074-5; 978-1-78801-589-9},\nUnique-ID = {WOS:000746504500012},\n}\n\n
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\n \n\n \n \n \n \n \n RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors.\n \n \n \n\n\n \n Thompson, A. P.; Bitsina, C.; Gray, J. L.; von Delft, F.; and Brennan, P. E.\n\n\n \n\n\n\n JOURNAL OF BIOLOGICAL CHEMISTRY, 296. JAN-JUN 2021.\n \n\n\n\n
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@article{ WOS:000672866400495,\nAuthor = {Thompson, Andrew P. and Bitsina, Christina and Gray, Janine L. and von\n   Delft, Frank and Brennan, Paul E.},\nTitle = {RHO to the DOCK for GDP disembarking: Structural insights into the DOCK\n   GTPase nucleotide exchange factors},\nJournal = {JOURNAL OF BIOLOGICAL CHEMISTRY},\nYear = {2021},\nVolume = {296},\nMonth = {JAN-JUN},\nDOI = {10.1016/j.jbc.2021.100521},\nArticle-Number = {100521},\nEISSN = {1083-351X},\nORCID-Numbers = {Bitsina, Christina/0000-0002-4808-945X\n   Gray, Janine/0000-0001-8679-2499\n   Thompson, Andrew Philip/0000-0002-3910-2317},\nUnique-ID = {WOS:000672866400495},\n}\n\n
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\n  \n 2020\n \n \n (7)\n \n \n
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\n \n\n \n \n \n \n \n Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.\n \n \n \n\n\n \n Vilema-Enriquez, G.; Quinlan, R.; Kilfeather, P.; Mazzone, R.; Saqlain, S.; del Molino del Barrio, I.; Donato, A.; Corda, G.; Li, F.; Vedadi, M.; Nemeth, A. H.; Brennan, P. E.; and Wade-Martins, R.\n\n\n \n\n\n\n JOURNAL OF BIOLOGICAL CHEMISTRY, 295(52): 17973-17985. DEC 25 2020.\n \n\n\n\n
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@article{ WOS:000603645900006,\nAuthor = {Vilema-Enriquez, Gabriela and Quinlan, Robert and Kilfeather, Peter and\n   Mazzone, Roberta and Saqlain, Saba and del Molino del Barrio, Irene and\n   Donato, Annalidia and Corda, Gabriele and Li, Fengling and Vedadi,\n   Masoud and Nemeth, Andrea H. and Brennan, Paul E. and Wade-Martins,\n   Richard},\nTitle = {Inhibition of the SUV4-20 H1 histone methyltransferase increases\n   frataxin expression in Friedreich's ataxia patient cells},\nJournal = {JOURNAL OF BIOLOGICAL CHEMISTRY},\nYear = {2020},\nVolume = {295},\nNumber = {52},\nPages = {17973-17985},\nMonth = {DEC 25},\nDOI = {10.1074/jbc.RA120.015533},\nEISSN = {1083-351X},\nResearcherID-Numbers = {Nemeth, Andrea/AGJ-1121-2022\n   },\nORCID-Numbers = {Vilema-Enriquez, Gabriela/0000-0003-0110-5894\n   Quinlan, Robert/0000-0002-7257-8878\n   Nemeth, Andrea/0000-0002-2941-7657\n   del Molino del Barrio, Irene/0000-0001-8906-805X},\nUnique-ID = {WOS:000603645900006},\n}\n\n
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\n \n\n \n \n \n \n \n Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death.\n \n \n \n\n\n \n Cottone, L.; Cribbs, A. P.; Khandelwal, G.; Wells, G.; Ligammari, L.; Philpott, M.; Tumber, A.; Lombard, P.; Hookway, E. S.; Szommer, T.; Johansson, C.; Brennan, P. E.; Pillay, N.; Jenner, R. G.; Oppermann, U.; and Flanagan, A. M.\n\n\n \n\n\n\n CANCER RESEARCH, 80(20): 4540-4551. OCT 15 2020.\n \n\n\n\n
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@article{ WOS:000582353000021,\nAuthor = {Cottone, Lucia and Cribbs, Adam P. and Khandelwal, Garima and Wells,\n   Graham and Ligammari, Lorena and Philpott, Martin and Tumber, Anthony\n   and Lombard, Patrick and Hookway, Edward S. and Szommer, Tamas and\n   Johansson, Catrine and Brennan, Paul E. and Pillay, Nischalan and\n   Jenner, Richard G. and Oppermann, Udo and Flanagan, Adrienne M.},\nTitle = {Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT)\n   and Promotes Chordoma Cell Death},\nJournal = {CANCER RESEARCH},\nYear = {2020},\nVolume = {80},\nNumber = {20},\nPages = {4540-4551},\nMonth = {OCT 15},\nDOI = {10.1158/0008-5472.CAN-20-1387},\nISSN = {0008-5472},\nEISSN = {1538-7445},\nResearcherID-Numbers = {Cottone, Lucia/W-4847-2019\n   Cribbs, Adam/AAN-4387-2020\n   Pillay, Nischalan/F-9536-2012\n   Jenner, Richard/J-8683-2012\n   Hookway, Edward/I-2613-2018\n   },\nORCID-Numbers = {Tumber, Anthony/0000-0003-1958-8353\n   Cribbs, Adam/0000-0001-5288-3077\n   Pillay, Nischalan/0000-0003-0579-4105\n   Szommer, Tamas/0000-0002-3811-4068\n   Jenner, Richard/0000-0002-2946-6811\n   Philpott, Martin/0000-0003-3632-0084\n   Flanagan, Adrienne/0000-0002-2832-1303},\nUnique-ID = {WOS:000582353000021},\n}\n\n
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\n \n\n \n \n \n \n \n Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.\n \n \n \n\n\n \n Khan Tareque, R.; Hassell-Hart, S.; Krojer, T.; Bradley, A.; Velupillai, S.; Talon, R.; Fairhead, M.; Day, I. J.; Bala, K.; Felix, R.; Kemmitt, P. D.; Brennan, P.; von Delft, F.; Diaz Saez, L.; Huber, K.; and Spencer, J.\n\n\n \n\n\n\n CHEMMEDCHEM, 15(24): 2513-2520. DEC 15 2020.\n \n\n\n\n
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@article{ WOS:000573115300001,\nAuthor = {Khan Tareque, Raysa and Hassell-Hart, Storm and Krojer, Tobias and\n   Bradley, Anthony and Velupillai, Srikannathasan and Talon, Romain and\n   Fairhead, Michael and Day, Iain J. and Bala, Kamlesh and Felix, Robert\n   and Kemmitt, Paul D. and Brennan, Paul and von Delft, Frank and Diaz\n   Saez, Laura and Huber, Kilian and Spencer, John},\nTitle = {Deliberately Losing Control of C-H Activation Processes in the Design of\n   Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism},\nJournal = {CHEMMEDCHEM},\nYear = {2020},\nVolume = {15},\nNumber = {24},\nPages = {2513-2520},\nMonth = {DEC 15},\nDOI = {10.1002/cmdc.202000543},\nEarlyAccessDate = {SEP 2020},\nISSN = {1860-7179},\nEISSN = {1860-7187},\nResearcherID-Numbers = {Krojer, Tobias/ABE-3829-2021\n   Huber, Kilian/L-6921-2015\n   },\nORCID-Numbers = {Fairhead, Michael/0000-0001-5361-3933\n   Hassell-Hart, Storm/0000-0001-6511-6037\n   Bala, Kamlesh/0000-0001-9485-424X\n   Diaz Saez, Laura/0000-0001-5814-7150\n   Day, Iain/0000-0002-2311-6837\n   Krojer, Tobias/0000-0003-0661-0814},\nUnique-ID = {WOS:000573115300001},\n}\n\n
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\n \n\n \n \n \n \n \n TargetDB: A target information aggregation tool and tractability predictor.\n \n \n \n\n\n \n De Cesco, S.; Davis, J. B.; and Brennan, P. E.\n\n\n \n\n\n\n PLOS ONE, 15(9). SEP 2 2020.\n \n\n\n\n
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@article{ WOS:000568877100052,\nAuthor = {De Cesco, Stephane and Davis, John B. and Brennan, Paul E.},\nTitle = {TargetDB: A target information aggregation tool and tractability\n   predictor},\nJournal = {PLOS ONE},\nYear = {2020},\nVolume = {15},\nNumber = {9},\nMonth = {SEP 2},\nDOI = {10.1371/journal.pone.0232644},\nArticle-Number = {e0232644},\nISSN = {1932-6203},\nResearcherID-Numbers = {De Cesco, Stephane/S-6857-2019\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   De Cesco, Stephane/0000-0003-4443-4217},\nUnique-ID = {WOS:000568877100052},\n}\n\n
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\n \n\n \n \n \n \n \n Targeting the Small GTPase Superfamily through Their Regulatory Proteins.\n \n \n \n\n\n \n Gray, J. L.; von Delft, F.; and Brennan, P. E.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59(16): 6342-6366. APR 16 2020.\n \n\n\n\n
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@article{ WOS:000523764400004,\nAuthor = {Gray, Janine L. and von Delft, Frank and Brennan, Paul E.},\nTitle = {Targeting the Small GTPase Superfamily through Their Regulatory Proteins},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2020},\nVolume = {59},\nNumber = {16},\nPages = {6342-6366},\nMonth = {APR 16},\nDOI = {10.1002/anie.201900585},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nORCID-Numbers = {von Delft, Frank/0000-0003-0378-0017\n   Brennan, Paul/0000-0002-8950-7646\n   Gray, Janine/0000-0001-8679-2499},\nUnique-ID = {WOS:000523764400004},\n}\n\n
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\n \n\n \n \n \n \n \n Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor.\n \n \n \n\n\n \n Hassell-Hart, S.; Runcie, A.; Krojer, T.; Doyle, J.; Lineham, E.; Ocasio, C. A.; Neto, B. A. D.; Fedorov, O.; Marsh, G.; Maple, H.; Felix, R.; Banks, R.; Ciulli, A.; Picaud, S.; Filippakopoulos, P.; von Delft, F.; Brennan, P. E.; Stewart, H. J. S.; Chevassut, T. J.; Walker, M.; Austin, C.; Morley, S.; and Spencer, J.\n\n\n \n\n\n\n ORGANOMETALLICS, 39(3): 408-416. FEB 10 2020.\n \n\n\n\n
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@article{ WOS:000513088500006,\nAuthor = {Hassell-Hart, Storm and Runcie, Andrew and Krojer, Tobias and Doyle,\n   Jordan and Lineham, Ella and Ocasio, Cory A. and Neto, Brenno A. D. and\n   Fedorov, Oleg and Marsh, Graham and Maple, Hannah and Felix, Robert and\n   Banks, Rebecca and Ciulli, Alessio and Picaud, Sarah and\n   Filippakopoulos, Panagis and von Delft, Frank and Brennan, Paul E. and\n   Stewart, Helen J. S. and Chevassut, Timothy J. and Walker, Martin and\n   Austin, Carol and Morley, Simon and Spencer, John},\nTitle = {Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET\n   Bromodomain Inhibitor},\nJournal = {ORGANOMETALLICS},\nYear = {2020},\nVolume = {39},\nNumber = {3},\nPages = {408-416},\nMonth = {FEB 10},\nDOI = {10.1021/acs.organomet.9b00750},\nISSN = {0276-7333},\nEISSN = {1520-6041},\nResearcherID-Numbers = {Fedorov, Oleg/A-3201-2019\n   SPENCER, John/P-5492-2019\n   Ciulli, Alessio/A-6279-2011\n   Krojer, Tobias/ABE-3829-2021\n   Spencer, John/C-2156-2008\n   A. D. Neto, Brenno/I-4579-2012},\nORCID-Numbers = {Runcie, Andrew/0000-0002-8096-9713\n   Hassell-Hart, Storm/0000-0001-6511-6037\n   Krojer, Tobias/0000-0003-0661-0814\n   Ocasio, Cory Antonio/0000-0002-4957-4131\n   Spencer, John/0000-0001-5231-8836\n   Fedorov, Oleg/0000-0001-5268-6399\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Marsh, Graham/0000-0003-0375-5145\n   A. D. Neto, Brenno/0000-0003-3783-9283},\nUnique-ID = {WOS:000513088500006},\n}\n\n
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\n \n\n \n \n \n \n \n Chemical Strategies for Evaluating New Drug Targets.\n \n \n \n\n\n \n Carter, A. J.; Seupel, R.; Brennan, P. E.; Sundstrom, M.; Introini, A.; and Mueller-Fahrnow, A.\n\n\n \n\n\n\n In Plowright, A., editor(s), TARGET DISCOVERY AND VALIDATION: METHODS AND STRATEGIES FOR DRUG DISCOVERY, of Methods and Principles in Medicinal Chemistry, pages 1-24. 2020.\n \n\n\n\n
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@incollection{ WOS:000668142800003,\nAuthor = {Carter, Adrian J. and Seupel, Raina and Brennan, Paul E. and Sundstrom,\n   Michael and Introini, Andrea and Mueller-Fahrnow, Anke},\nEditor = {Plowright, AT},\nTitle = {Chemical Strategies for Evaluating New Drug Targets},\nBooktitle = {TARGET DISCOVERY AND VALIDATION: METHODS AND STRATEGIES FOR DRUG\n   DISCOVERY},\nSeries = {Methods and Principles in Medicinal Chemistry},\nYear = {2020},\nPages = {1-24},\nISSN = {1865-0562},\nISBN = {978-3-527-81825-9; 978-3-527-34529-8},\nResearcherID-Numbers = {Introini, Andrea/ABC-9951-2020},\nUnique-ID = {WOS:000668142800003},\n}\n\n
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\n  \n 2019\n \n \n (13)\n \n \n
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\n \n\n \n \n \n \n \n Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.\n \n \n \n\n\n \n Ni, X.; Heidenreich, D.; Christott, T.; Bennet, J.; Moustakim, M.; Brennan, P. E.; Fedorov, O.; Knapp, S.; and Chaikuad, A.\n\n\n \n\n\n\n ACS MEDICINAL CHEMISTRY LETTERS, 10(12): 1661+. DEC 2019.\n \n\n\n\n
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@article{ WOS:000503114700011,\nAuthor = {Ni, Xiaomin and Heidenreich, David and Christott, Thomas and Bennet,\n   James and Moustakim, Moses and Brennan, Paul E. and Fedorov, Oleg and\n   Knapp, Stefan and Chaikuad, Apirat},\nTitle = {Structural Insights into Interaction Mechanisms of Alternative\n   Piperazine-urea YEATS Domain Binders in MLLT1},\nJournal = {ACS MEDICINAL CHEMISTRY LETTERS},\nYear = {2019},\nVolume = {10},\nNumber = {12},\nPages = {1661+},\nMonth = {DEC},\nDOI = {10.1021/acsmedchemlett.9b00460},\nISSN = {1948-5875},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Fedorov, Oleg/A-3201-2019\n   Moustakim, Moses/LKM-9655-2024\n   },\nORCID-Numbers = {Fedorov, Oleg/0000-0001-5268-6399\n   Ni, Xiaomin/0000-0002-7769-8297\n   Bennett, James/0000-0003-1396-8400\n   Brennan, Paul/0000-0002-8950-7646\n   Chaikuad, Apirat/0000-0003-1120-2209\n   Knapp, Stefan/0000-0001-5995-6494},\nUnique-ID = {WOS:000503114700011},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).\n \n \n \n\n\n \n Xiong, Y.; Greschik, H.; Johansson, C.; Seifert, L.; Bacher, J.; Park, K.; Babault, N.; Martini, M.; Fagan, V.; Li, F.; Chau, I.; Christott, T.; Dilworth, D.; Barsyte-Lovejoy, D.; Vedadi, M.; Arrowsmith, C. H.; Brennan, P.; Fedorov, O.; Jung, M.; Farnie, G.; Liu, J.; Oppermann, U.; Schuele, R.; and Jin, J.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 62(20): 8996-9007. OCT 24 2019.\n \n\n\n\n
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@article{ WOS:000492801800007,\nAuthor = {Xiong, Yan and Greschik, Holger and Johansson, Catrine and Seifert,\n   Ludwig and Bacher, Johannes and Park, Kwang-su and Babault, Nicolas and\n   Martini, Michael and Fagan, Vincent and Li, Fengling and Chau, Irene and\n   Christott, Thomas and Dilworth, David and Barsyte-Lovejoy, Dalia and\n   Vedadi, Masoud and Arrowsmith, Cheryl H. and Brennan, Paul and Fedorov,\n   Oleg and Jung, Manfred and Farnie, Gillian and Liu, Jing and Oppermann,\n   Udo and Schuele, Roland and Jin, Jian},\nTitle = {Discovery of a Potent and Selective Fragment-like Inhibitor of\n   Methyllysine Reader Protein Spindlin 1 (SPIN1)},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2019},\nVolume = {62},\nNumber = {20},\nPages = {8996-9007},\nMonth = {OCT 24},\nDOI = {10.1021/acs.jmedchem.9b00522},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Schüle, Rebecca/B-5763-2019\n   liu, jing/G-3957-2011\n   Jung, Manfred/Q-8029-2016\n   farnie, gillian/GLT-8777-2022\n   Fedorov, Oleg/A-3201-2019\n   Park, Kwangsu/AAJ-7411-2021\n   },\nORCID-Numbers = {Park, Kwangsu/0000-0002-1910-3937\n   Fedorov, Oleg/0000-0001-5268-6399\n   Seifert, Ludwig/0000-0003-3203-7361\n   Fagan, Vincent/0000-0001-9714-2790\n   Liu, Jing/0000-0003-4740-243X},\nUnique-ID = {WOS:000492801800007},\n}\n\n
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\n \n\n \n \n \n \n \n A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.\n \n \n \n\n\n \n Fagan, V.; Johansson, C.; Gileadi, C.; Monteiro, O.; Dunford, J. E.; Nibhani, R.; Philpott, M.; Malzahn, J.; Wells, G.; Faram, R.; Cribbs, A. P.; Halidi, N.; Li, F.; Chau, I.; Greschik, H.; Velupillai, S.; Allali-Hassani, A.; Bennett, J.; Christott, T.; Giroud, C.; Lewis, A. M.; Huber, K. V. M.; Athanasou, N.; Bountrat, C.; Jung, M.; Schuele, R.; Vedadi, M.; Arrowsmith, C.; Xion, Y.; Jin, J.; Fedorov, O.; Farnie, G.; Brennan, P. E.; and Oppermann, U.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 62(20): 9008-9025. OCT 24 2019.\n \n\n\n\n
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@article{ WOS:000492801800008,\nAuthor = {Fagan, Vincent and Johansson, Catrine and Gileadi, Carina and Monteiro,\n   Octovia and Dunford, James E. and Nibhani, Reshma and Philpott, Martin\n   and Malzahn, Jessica and Wells, Graham and Faram, Ruth and Cribbs, Adam\n   P. and Halidi, Nadia and Li, Fengling and Chau, Irene and Greschik,\n   Holger and Velupillai, Srikannathasan and Allali-Hassani, Abdellah and\n   Bennett, James and Christott, Thomas and Giroud, Charline and Lewis,\n   Andrew M. and Huber, Kilian V. M. and Athanasou, Nick and Bountrat, Chas\n   and Jung, Manfred and Schuele, Roland and Vedadi, Masoud and Arrowsmith,\n   Cheryl and Xion, Yan and Jin, Jian and Fedorov, Oleg and Farnie, Gillian\n   and Brennan, Paul E. and Oppermann, Udo},\nTitle = {A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate\n   Chromatin Function},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2019},\nVolume = {62},\nNumber = {20},\nPages = {9008-9025},\nMonth = {OCT 24},\nDOI = {10.1021/acs.jmedchem.9b00562},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Jung, Manfred/Q-8029-2016\n   Fedorov, Oleg/A-3201-2019\n   farnie, gillian/GLT-8777-2022\n   Cribbs, Adam/AAN-4387-2020\n   Schüle, Rebecca/B-5763-2019\n   Huber, Kilian/L-6921-2015\n   Brown, Tom/A-6655-2010\n   },\nORCID-Numbers = {Nibhani, Reshma/0000-0002-4344-2795\n   Dunford, James/0000-0002-9932-4042\n   Fagan, Vincent/0000-0001-9714-2790\n   Halidi, Nadia/0000-0003-0613-2365\n   Philpott, Martin/0000-0003-3632-0084\n   Cribbs, Adam/0000-0001-5288-3077\n   Fedorov, Oleg/0000-0001-5268-6399},\nUnique-ID = {WOS:000492801800008},\n}\n\n
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\n \n\n \n \n \n \n \n C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.\n \n \n \n\n\n \n Le Bihan, Y.; Lanigan, R. M.; Atrash, B.; McLaughlin, M. G.; Velupillai, S.; Malcolm, A. G.; England, K. S.; Ruda, G. F.; Mok, N. Y.; Tumber, A.; Tomlin, K.; Saville, H.; Shehu, E.; McAndrew, C.; Carmichael, L.; Bennett, J. M.; Jeganathan, F.; Eve, P.; Donovan, A.; Hayes, A.; Wood, F.; Raynaud, F. I.; Fedorov, O.; Brennan, P. E.; Burke, R.; van Montfort, R. L. M.; Rossanese, O. W.; Blagg, J.; and Bavetsias, V.\n\n\n \n\n\n\n EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 177: 316-337. SEP 1 2019.\n \n\n\n\n
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@article{ WOS:000474316600022,\nAuthor = {Le Bihan, Yann-Vai and Lanigan, Rachel M. and Atrash, Butrus and\n   McLaughlin, Mark G. and Velupillai, Srikannathasan and Malcolm, Andrew\n   G. and England, Katherine S. and Ruda, Gian Filippo and Mok, N. Yi and\n   Tumber, Anthony and Tomlin, Kathy and Saville, Harry and Shehu, Erald\n   and McAndrew, Craig and Carmichael, LeAnne and Bennett, James M. and\n   Jeganathan, Fiona and Eve, Paul and Donovan, Adam and Hayes, Angela and\n   Wood, Francesca and Raynaud, Florence I. and Fedorov, Oleg and Brennan,\n   Paul E. and Burke, Rosemary and van Montfort, Rob L. M. and Rossanese,\n   Olivia W. and Blagg, Julian and Bavetsias, Vassilios},\nTitle = {C8-substituted pyrido{[}3,4-d]pyrimidin-4(3H)-ones:\n   Studies towards the identification of potent, cell penetrant Jumonji C\n   domain containing histone lysine demethylase 4 subfamily (KDM4)\n   inhibitors, compound profiling in cell-based target engagement assays},\nJournal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2019},\nVolume = {177},\nPages = {316-337},\nMonth = {SEP 1},\nDOI = {10.1016/j.ejmech.2019.05.041},\nISSN = {0223-5234},\nEISSN = {1768-3254},\nResearcherID-Numbers = {Fedorov, Oleg/A-3201-2019\n   McLaughlin, Mark/N-8192-2019\n   Lanigan, Rachel/B-4830-2015\n   },\nORCID-Numbers = {Le Bihan, Yann-Vai/0000-0002-6850-9706\n   Rossanese, Olivia/0000-0002-1262-9522\n   England, Katherine/0000-0002-4921-7505\n   Fedorov, Oleg/0000-0001-5268-6399\n   Tumber, Anthony/0000-0003-1958-8353\n   Raynaud, Florence/0000-0003-0957-6279\n   McLaughlin, Mark/0000-0002-5999-4703},\nUnique-ID = {WOS:000474316600022},\n}\n\n
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\n \n\n \n \n \n \n \n A genetics-led approach defines the drug target landscape of 30 immune-related traits.\n \n \n \n\n\n \n Fang, H.; Beckmann, G.; Bountra, C.; Bowness, P.; Burgess-Brown, N.; Carpenter, L.; Chen, L.; Damerell, D.; Egner, U.; Fujii, R.; Howe, T.; Jakobsson, P.; Katopodis, A.; Knight, J. C.; Marsden, B. D.; De Martino, J.; Matthias, G.; McVean, G.; Mueller-Fahrnow, A.; Malarstig, A.; O'Callaghan, C. A.; Ostermann, N.; Paez-cortez, J. R.; Peeters, P. J.; Prinz, F.; Soulard, P.; Sundstrom, M.; Yabuki, C.; Vlach, J.; De Wolf, H.; Knezevic, B.; Burnham, K. L.; Osgood, J.; Sanniti, A.; Lara, A. L.; Kasela, S.; De Cesco, S.; Wegner, J. K.; Handunnetthi, L.; McCann, F. E.; Sekine, T.; Brennan, P. E.; Sundstrom, Y.; Milani, L.; Berg, L.; Gohlmann, H. W.; Fairfax, B. P.; and Consortium, U.\n\n\n \n\n\n\n NATURE GENETICS, 51(7): 1082+. JUL 2019.\n \n\n\n\n
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@article{ WOS:000473491900006,\nAuthor = {Fang, Hai and Beckmann, Georg and Bountra, Chas and Bowness, Paul and\n   Burgess-Brown, Nicola and Carpenter, Liz and Chen, Liye and Damerell,\n   David and Egner, Ursula and Fujii, Ryo and Howe, Trevor and Jakobsson,\n   Per-Johan and Katopodis, Andreas and Knight, Julian C. and Marsden,\n   Brian D. and De Martino, Julie and Matthias, Gstaiger and McVean, Gilean\n   and Mueller-Fahrnow, Anke and Malarstig, Anders and O'Callaghan, Chris\n   A. and Ostermann, Nils and Paez-cortez, Jesus R. and Peeters, Pieter J.\n   and Prinz, Florian and Soulard, Patricia and Sundstrom, Michael and\n   Yabuki, Chiori and Vlach, Jaromir and De Wolf, Hans and Knezevic, Bogdan\n   and Burnham, Katie L. and Osgood, Julie and Sanniti, Anna and Lara,\n   Alicia Lledo and Kasela, Silva and De Cesco, Stephane and Wegner, Jorg\n   K. and Handunnetthi, Lahiru and McCann, Fiona E. and Sekine, Takuya and\n   Brennan, Paul E. and Sundstrom, Yvonne and Milani, Lili and Berg, Louise\n   and Gohlmann, Hinrich W. and Fairfax, Benjamin P. and ULTRA-DD\n   Consortium},\nTitle = {A genetics-led approach defines the drug target landscape of 30\n   immune-related traits},\nJournal = {NATURE GENETICS},\nYear = {2019},\nVolume = {51},\nNumber = {7},\nPages = {1082+},\nMonth = {JUL},\nDOI = {10.1038/s41588-019-0456-1},\nISSN = {1061-4036},\nEISSN = {1546-1718},\nResearcherID-Numbers = {Göhlmann, Hinrich/T-9848-2019\n   De Cesco, Stephane/S-6857-2019\n   Chen, Li-Ye/AAE-3399-2019\n   Sekine, Takuya/LRD-1464-2024\n   Jakobsson, Per-Johan/ABC-5594-2021\n   Wegner, Jörg/C-6598-2009\n   Bowness, Paul/AAH-2484-2019\n   Fang, Hai/H-7879-2012\n   Milani, Lili/C-8759-2011\n   Knight, Julian/W-2399-2019\n   },\nORCID-Numbers = {Knezevic, Bogdan/0000-0002-2598-0629\n   Berg, Louise/0000-0001-6538-2837\n   Fairfax, Benjamin/0000-0001-7413-5002\n   Milani, Lili/0000-0002-5323-3102\n   Knight, Julian/0000-0002-0377-5536\n   Wegner, Jorg Kurt/0000-0002-1852-9434\n   De Cesco, Stephane/0000-0003-4443-4217\n   Handunnetthi, Lahiru/0000-0002-8242-3722\n   Jakobson, Per-Johan/0000-0001-7665-9715\n   Burnham, Katie/0000-0001-8680-2933\n   Peeters, Pieter Johan/0000-0003-1252-8139\n   McCann, Fiona/0000-0001-8151-8781\n   Fang, Hai/0000-0003-3961-8572},\nUnique-ID = {WOS:000473491900006},\n}\n\n
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\n \n\n \n \n \n \n \n Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.\n \n \n \n\n\n \n Resnick, E.; Bradley, A.; Gan, J.; Douangamath, A.; Krojer, T.; Sethi, R.; Geurink, P. P.; Aimon, A.; Amitai, G.; Bellini, D.; Bennett, J.; Fairhead, M.; Fedorov, O.; Gabizon, R.; Gan, J.; Gu, J.; Plotnikov, A.; Reznik, N.; Ruda, G. F.; Diaz-Saez, L.; Straub, V. M.; Szommer, T.; Velupillai, S.; Zaidman, D.; Zhang, Y.; Coker, A. R.; Dowson, C. G.; Barr, H. M.; Wang, C.; Huber, K. V. M.; Brennan, P. E.; Ovaa, H.; von Delft, F.; and London, N.\n\n\n \n\n\n\n JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141(22): 8951-8968. JUN 5 2019.\n \n\n\n\n
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@article{ WOS:000470939200044,\nAuthor = {Resnick, Efrat and Bradley, Anthony and Gan, Jinrui and Douangamath,\n   Alice and Krojer, Tobias and Sethi, Ritika and Geurink, Paul P. and\n   Aimon, Anthony and Amitai, Gabriel and Bellini, Dom and Bennett, James\n   and Fairhead, Michael and Fedorov, Oleg and Gabizon, Ronen and Gan, Jin\n   and Gu, Jingxu and Plotnikov, Alexander and Reznik, Nava and Ruda, Gian\n   Filippo and Diaz-Saez, Laura and Straub, Verena M. and Szommer, Tamas\n   and Velupillai, Srikannathasan and Zaidman, Daniel and Zhang, Yanling\n   and Coker, Alun R. and Dowson, Christopher G. and Barr, Haim M. and\n   Wang, Chu and Huber, Kilian V. M. and Brennan, Paul E. and Ovaa, Huib\n   and von Delft, Frank and London, Nir},\nTitle = {Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening},\nJournal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2019},\nVolume = {141},\nNumber = {22},\nPages = {8951-8968},\nMonth = {JUN 5},\nDOI = {10.1021/jacs.9b02822},\nISSN = {0002-7863},\nEISSN = {1520-5126},\nResearcherID-Numbers = {Wang, Chu/AAE-8759-2021\n   Gabizon, Ronen/KVY-7919-2024\n   Fedorov, Oleg/A-3201-2019\n   Huber, Kilian/L-6921-2015\n   Krojer, Tobias/ABE-3829-2021\n   Gan, Jin/HHZ-1763-2022\n   ovaa, huib/M-2334-2016\n   Dowson, Christopher/ABG-5083-2021\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Gan, Jin/0000-0002-8785-3035\n   Aimon, Anthony/0000-0002-9135-129X\n   ovaa, huib/0000-0002-0068-054X\n   Szommer, Tamas/0000-0002-3811-4068\n   Straub, Volker/0000-0001-9046-3540\n   London, Nir/0000-0003-2687-0699\n   Dowson, Christopher/0000-0002-8294-8836\n   Fairhead, Michael/0000-0001-5361-3933\n   Fedorov, Oleg/0000-0001-5268-6399\n   Sethi, Ritika/0000-0001-6015-7710\n   Guo, Jingxu/0000-0002-1568-4842\n   Zaidman, Daniel/0000-0003-2695-1675\n   Krojer, Tobias/0000-0003-0661-0814\n   Straub, Verena M./0000-0001-5013-5569\n   Gabizon, Ronen/0000-0002-3626-5073\n   Bennett, James/0000-0003-1396-8400\n   von Delft, Frank/0000-0003-0378-0017\n   Diaz Saez, Laura/0000-0001-5814-7150},\nUnique-ID = {WOS:000470939200044},\n}\n\n
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\n \n\n \n \n \n \n \n ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.\n \n \n \n\n\n \n Carvalho, D.; Taylor, K. R.; Olaciregui, N. G.; Molinari, V.; Clarke, M.; Mackay, A.; Ruddle, R.; Henley, A.; Valenti, M.; Hayes, A.; Brandon, A. D. H.; Eccles, S. A.; Raynaud, F.; Boudhar, A.; Monje, M.; Popov, S.; Moore, A. S.; Mora, J.; Cruz, O.; Vinci, M.; Brennan, P. E.; Bullock, A. N.; Carcaboso, A. M.; and Jones, C.\n\n\n \n\n\n\n COMMUNICATIONS BIOLOGY, 2. MAY 9 2019.\n \n\n\n\n
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@article{ WOS:000468005700001,\nAuthor = {Carvalho, Diana and Taylor, Kathryn R. and Olaciregui, Nagore Gene and\n   Molinari, Valeria and Clarke, Matthew and Mackay, Alan and Ruddle, Ruth\n   and Henley, Alan and Valenti, Melanie and Hayes, Angela and Brandon,\n   Alexis De Haven and Eccles, Suzanne A. and Raynaud, Florence and\n   Boudhar, Aicha and Monje, Michelle and Popov, Sergey and Moore, Andrew\n   S. and Mora, Jaume and Cruz, Ofelia and Vinci, Mara and Brennan, Paul E.\n   and Bullock, Alex N. and Carcaboso, Angel Montero and Jones, Chris},\nTitle = {ALK2 inhibitors display beneficial effects in preclinical models of\n   ACVR1 mutant diffuse intrinsic pontine glioma},\nJournal = {COMMUNICATIONS BIOLOGY},\nYear = {2019},\nVolume = {2},\nMonth = {MAY 9},\nDOI = {10.1038/s42003-019-0420-8},\nArticle-Number = {156},\nEISSN = {2399-3642},\nResearcherID-Numbers = {Jones, Chris/ABE-6059-2021\n   Moore, Andrew/I-6275-2012\n   Ruddle, Ruth/MTD-4041-2025\n   Maio, Michele/AEV-2647-2022\n   cruz, ofelia/AAE-7058-2020\n   Vinci, Maria/AAI-1092-2019\n   },\nORCID-Numbers = {Raynaud, Florence/0000-0003-0957-6279\n   Carvalho, Diana/0000-0001-6881-6151\n   Carcaboso, Angel/0000-0002-8485-426X\n   Vinci, Maria/0000-0002-7952-6771\n   Brennan, Paul/0000-0002-8950-7646\n   cruz, ofelia/0000-0001-7102-3283\n   Moore, Andrew/0000-0001-8062-1779},\nUnique-ID = {WOS:000468005700001},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery of Pyrrolo[3,2-d]pyrimidin-4-one Derivatives as a New Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor Bromodomain.\n \n \n \n\n\n \n Huang, L.; Li, H.; Li, L.; Niu, L.; Seupel, R.; Wu, C.; Cheng, W.; Chen, C.; Ding, B.; Brennan, P. E.; and Yang, S.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 62(9): 4526-4542. MAY 9 2019.\n \n\n\n\n
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@article{ WOS:000467781700017,\nAuthor = {Huang, Luyi and Li, Hui and Li, Linli and Niu, Lu and Seupel, Raina and\n   Wu, Chengyong and Cheng, Wei and Chen, Chong and Ding, Bisen and\n   Brennan, Paul E. and Yang, Shengyong},\nTitle = {Discovery of Pyrrolo{[}3,2-d]pyrimidin-4-one Derivatives as a New\n   Class of Potent and Cell-Active Inhibitors of P300/CBP-Associated Factor\n   Bromodomain},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2019},\nVolume = {62},\nNumber = {9},\nPages = {4526-4542},\nMonth = {MAY 9},\nDOI = {10.1021/acs.jmedchem.9b00096},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Chen, Yu-Wen/AAU-8885-2020\n   },\nORCID-Numbers = {Huang, Luyi/0000-0002-0377-877X\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000467781700017},\n}\n\n
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\n \n\n \n \n \n \n \n A chemical toolbox for the study of bromodomains and epigenetic signaling.\n \n \n \n\n\n \n Wu, Q.; Heidenreich, D.; Zhou, S.; Ackloo, S.; Kraemer, A.; Nakka, K.; Lima-Fernandes, E.; Deblois, G.; Duan, S.; Vellanki, R. N.; Li, F.; Vedadi, M.; Dilworth, J.; Lupien, M.; Brennan, P. E.; Arrowsmith, C. H.; Mueller, S.; Fedorov, O.; Filippakopoulos, P.; and Knapp, S.\n\n\n \n\n\n\n NATURE COMMUNICATIONS, 10. APR 23 2019.\n \n\n\n\n
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@article{ WOS:000465202900005,\nAuthor = {Wu, Qin and Heidenreich, David and Zhou, Stanley and Ackloo, Suzanne and\n   Kraemer, Andreas and Nakka, Kiran and Lima-Fernandes, Evelyne and\n   Deblois, Genevieve and Duan, Shili and Vellanki, Ravi N. and Li,\n   Fengling and Vedadi, Masoud and Dilworth, Jeffrey and Lupien, Mathieu\n   and Brennan, Paul E. and Arrowsmith, Cheryl H. and Mueller, Susanne and\n   Fedorov, Oleg and Filippakopoulos, Panagis and Knapp, Stefan},\nTitle = {A chemical toolbox for the study of bromodomains and epigenetic\n   signaling},\nJournal = {NATURE COMMUNICATIONS},\nYear = {2019},\nVolume = {10},\nMonth = {APR 23},\nDOI = {10.1038/s41467-019-09672-2},\nArticle-Number = {1915},\nISSN = {2041-1723},\nResearcherID-Numbers = {Vellanki, Ravi/M-8738-2019\n   Knapp, Stefan/AAG-2347-2019\n   Zhou, Stanley/H-8466-2019\n   Nakka, Kiran/CAJ-3374-2022\n   Fedorov, Oleg/A-3201-2019\n   Lupien, Mathieu/KFB-6691-2024\n   },\nORCID-Numbers = {Lima Fernandes, Evelyne/0000-0002-3628-9745\n   Lupien, Mathieu/0000-0003-0929-9478\n   Nakka, Kiran/0000-0002-8418-9343\n   Deblois, Genevieve/0000-0002-3067-2807\n   Brennan, Paul/0000-0002-8950-7646\n   Wu, Qin/0009-0008-0901-9943\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Arrowsmith, Cheryl/0000-0002-4971-3250\n   Vellanki, Ravi/0000-0002-5081-3187\n   Fedorov, Oleg/0000-0001-5268-6399\n   Kramer, Andreas/0000-0003-3294-2660\n   Ackloo, Suzanne/0000-0002-9696-1839},\nUnique-ID = {WOS:000465202900005},\n}\n\n
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\n \n\n \n \n \n \n \n SuCOS: A pharmacophoric-shape overlap metric for comparing binding modes.\n \n \n \n\n\n \n Leung, S.; Bodkin, M.; von Delft, F.; Brennan, P.; and Morris, G.\n\n\n \n\n\n\n ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 257. MAR 31 2019.\n National Meeting of the American-Chemical-Society (ACS), Orlando, FL, MAR 31-APR 04, 2019\n\n\n\n
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@article{ WOS:000478860503841,\nAuthor = {Leung, Susan and Bodkin, Michael and von Delft, Frank and Brennan, Paul\n   and Morris, Garrett},\nTitle = {SuCOS: A pharmacophoric-shape overlap metric for comparing binding modes},\nJournal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2019},\nVolume = {257},\nMeeting = {14},\nMonth = {MAR 31},\nNote = {National Meeting of the American-Chemical-Society (ACS), Orlando, FL,\n   MAR 31-APR 04, 2019},\nOrganization = {Amer Chem Soc},\nISSN = {0065-7727},\nResearcherID-Numbers = {Morris, Garrett/F-2465-2019},\nUnique-ID = {WOS:000478860503841},\n}\n\n
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\n \n\n \n \n \n \n \n An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.\n \n \n \n\n\n \n D'Ascenzio, M.; Pugh, K. M.; Konietzny, R.; Berridge, G.; Tallant, C.; Hashem, S.; Monteiro, O.; Thomas, J. R.; Schirle, M.; Knapp, S.; Marsden, B.; Fedorov, O.; Bountra, C.; Kessler, B. M.; and Brennan, P. E.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(4): 1007-1012. JAN 21 2019.\n \n\n\n\n
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@article{ WOS:000456260200007,\nAuthor = {D'Ascenzio, Melissa and Pugh, Kathryn M. and Konietzny, Rebecca and\n   Berridge, Georgina and Tallant, Cynthia and Hashem, Shaima and Monteiro,\n   Octovia and Thomas, Jason R. and Schirle, Markus and Knapp, Stefan and\n   Marsden, Brian and Fedorov, Oleg and Bountra, Chas and Kessler, Benedikt\n   M. and Brennan, Paul E.},\nTitle = {An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino\n   Acid Residues within Bromodomains},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2019},\nVolume = {58},\nNumber = {4},\nPages = {1007-1012},\nMonth = {JAN 21},\nDOI = {10.1002/anie.201807825},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nResearcherID-Numbers = {Fedorov, Oleg/A-3201-2019\n   Knapp, Stefan/AAG-2347-2019\n   Kessler, Benedikt/JGC-6978-2023\n   Thomas, Jason/LQJ-9980-2024\n   },\nORCID-Numbers = {Kessler, Benedikt/0000-0002-8160-2446\n   Tallant, Cynthia/0000-0001-5645-435X\n   Brennan, Paul/0000-0002-8950-7646\n   Hashem, Shaima/0000-0003-1693-3473\n   Fedorov, Oleg/0000-0001-5268-6399},\nUnique-ID = {WOS:000456260200007},\n}\n\n
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\n \n\n \n \n \n \n \n Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.\n \n \n \n\n\n \n Vazquez-Rodriguez, S.; Wright, M.; Rogers, C. M.; Cribbs, A. P.; Velupillai, S.; Philpott, M.; Lee, H.; Dunford, J. E.; Huber, K. V. M.; Robers, M. B.; Vasta, J. D.; Thezenas, M.; Bonham, S.; Kessler, B.; Bennett, J.; Fedorov, O.; Raynaud, F.; Donovan, A.; Blagg, J.; Bavetsias, V.; Oppermann, U.; Bountra, C.; Kawamura, A.; and Brennan, P. E.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(2): 515-519. JAN 8 2019.\n \n\n\n\n
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@article{ WOS:000454944900022,\nAuthor = {Vazquez-Rodriguez, Saleta and Wright, Miranda and Rogers, Catherine M.\n   and Cribbs, Adam P. and Velupillai, Srikannathasan and Philpott, Martin\n   and Lee, Henry and Dunford, James E. and Huber, Kilian V. M. and Robers,\n   Matthew B. and Vasta, James D. and Thezenas, Marie-Laetitia and Bonham,\n   Sarah and Kessler, Benedikt and Bennett, James and Fedorov, Oleg and\n   Raynaud, Florence and Donovan, Adam and Blagg, Julian and Bavetsias,\n   Vassilios and Oppermann, Udo and Bountra, Chas and Kawamura, Akane and\n   Brennan, Paul E.},\nTitle = {Design, Synthesis and Characterization of Covalent KDM5 Inhibitors},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2019},\nVolume = {58},\nNumber = {2},\nPages = {515-519},\nMonth = {JAN 8},\nDOI = {10.1002/anie.201810179},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nResearcherID-Numbers = {Cribbs, Adam/U-4055-2019\n   Kessler, Benedikt/JGC-6978-2023\n   Fedorov, Oleg/A-3201-2019\n   Brown, Tom/A-6655-2010\n   Kawamura, Akane/I-4047-2018\n   Vazquez-Rodriguez, Saleta/L-4047-2014\n   Huber, Kilian/L-6921-2015\n   },\nORCID-Numbers = {Fedorov, Oleg/0000-0001-5268-6399\n   Kessler, Benedikt/0000-0002-8160-2446\n   Vazquez-Rodriguez, Saleta/0000-0003-1356-8984\n   Huber, Kilian/0000-0002-1103-5300\n   Cribbs, Adam/0000-0001-5288-3077\n   Brennan, Paul/0000-0002-8950-7646\n   Philpott, Martin/0000-0003-3632-0084\n   Dunford, James/0000-0002-9932-4042\n   Raynaud, Florence/0000-0003-0957-6279\n   Bennett, James/0000-0003-1396-8400},\nUnique-ID = {WOS:000454944900022},\n}\n\n
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\n \n\n \n \n \n \n \n Chemical Probes.\n \n \n \n\n\n \n Donner, A.; King, H.; Brennan, P. E.; Moustakim, M.; and Zuercher, W. J.\n\n\n \n\n\n\n In Sippl, W; and Jung, M, editor(s), EPIGENETIC DRUG DISCOVERY, pages 133-152. 2019.\n \n\n\n\n
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@incollection{ WOS:000483635500008,\nAuthor = {Donner, Amy and King, Heather and Brennan, Paul E. and Moustakim, Moses\n   and Zuercher, William J.},\nEditor = {Sippl, W and Jung, M},\nTitle = {Chemical Probes},\nBooktitle = {EPIGENETIC DRUG DISCOVERY},\nYear = {2019},\nPages = {133-152},\nISBN = {978-3-527-80928-8; 978-3-527-34314-0},\nResearcherID-Numbers = {Moustakim, Moses/LKM-9655-2024\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000483635500008},\n}\n\n
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\n \n\n \n \n \n \n \n Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL).\n \n \n \n\n\n \n Heidenreich, D.; Moustakim, M.; Schmidt, J.; Merk, D.; Brennan, P. E.; Fedorov, O.; Chaikuad, A.; and Knapp, S.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 61(23): 10929-10934. DEC 13 2018.\n \n\n\n\n
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@article{ WOS:000453488200038,\nAuthor = {Heidenreich, David and Moustakim, Moses and Schmidt, Jurema and Merk,\n   Daniel and Brennan, Paul E. and Fedorov, Oleg and Chaikuad, Apirat and\n   Knapp, Stefan},\nTitle = {Structure-Based Approach toward Identification of Inhibitory Fragments\n   for Eleven-Nineteen-Leukemia Protein (ENL)},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2018},\nVolume = {61},\nNumber = {23},\nPages = {10929-10934},\nMonth = {DEC 13},\nDOI = {10.1021/acs.jmedchem.8b01457},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Merk, Daniel/AAA-6279-2019\n   Fedorov, Oleg/A-3201-2019\n   Moustakim, Moses/LKM-9655-2024\n   Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {Chaikuad, Apirat/0000-0003-1120-2209\n   Fedorov, Oleg/0000-0001-5268-6399\n   Knapp, Stefan/0000-0001-5995-6494\n   Heidenreich, David/0000-0003-2806-8835\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000453488200038},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery of an MLLT1/3 YEATS Domain Chemical Probe.\n \n \n \n\n\n \n Moustakim, M.; Christott, T.; Monteiro, O. P.; Bennett, J.; Giroud, C.; Ward, J.; Rogers, C. M.; Smith, P.; Panagakou, I.; Diaz-Saez, L.; Felce, S. L.; Gamble, V.; Gileadi, C.; Halidi, N.; Heidenreich, D.; Chaikuad, A.; Knapp, S.; Huber, K. V. M.; Farnie, G.; Heer, J.; Manevski, N.; Poda, G.; Al-awar, R.; Dixon, D. J.; Brennan, P. E.; and Fedorov, O.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57(50): 16302-16307. DEC 10 2018.\n \n\n\n\n
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@article{ WOS:000453346300006,\nAuthor = {Moustakim, Moses and Christott, Thomas and Monteiro, Octovia P. and\n   Bennett, James and Giroud, Charline and Ward, Jennifer and Rogers,\n   Catherine M. and Smith, Paul and Panagakou, Ioanna and Diaz-Saez, Laura\n   and Felce, Suet Ling and Gamble, Vicki and Gileadi, Carina and Halidi,\n   Nadia and Heidenreich, David and Chaikuad, Apirat and Knapp, Stefan and\n   Huber, Kilian V. M. and Farnie, Gillian and Heer, Jag and Manevski,\n   Nenad and Poda, Gennady and Al-awar, Rima and Dixon, Darren J. and\n   Brennan, Paul E. and Fedorov, Oleg},\nTitle = {Discovery of an MLLT1/3 YEATS Domain Chemical Probe},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2018},\nVolume = {57},\nNumber = {50},\nPages = {16302-16307},\nMonth = {DEC 10},\nDOI = {10.1002/anie.201810617},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nResearcherID-Numbers = {Moustakim, Moses/LKM-9655-2024\n   farnie, gillian/GLT-8777-2022\n   Fedorov, Oleg/A-3201-2019\n   Knapp, Stefan/AAG-2347-2019\n   Huber, Kilian/L-6921-2015\n   },\nORCID-Numbers = {Farnie, Gillian/0000-0002-1407-2529\n   Halidi, Nadia/0000-0003-0613-2365\n   Huber, Kilian/0000-0002-1103-5300\n   Chaikuad, Apirat/0000-0003-1120-2209\n   Diaz Saez, Laura/0000-0001-5814-7150\n   Heidenreich, David/0000-0003-2806-8835\n   Felce, Ling/0000-0001-8534-1629\n   Fedorov, Oleg/0000-0001-5268-6399\n   Bennett, James/0000-0003-1396-8400\n   Smith, Paul/0000-0003-1079-9330\n   Moustakim, Moses/0000-0002-5006-5684},\nUnique-ID = {WOS:000453346300006},\n}\n\n
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\n \n\n \n \n \n \n \n Bench-Stable Transfer Reagent Facilitates the Generation of Trifluoromethyl-sulfonimidamides.\n \n \n \n\n\n \n Wright, M.; Martinez-Lamenca, C.; Leenaerts, J. E.; Brennan, P. E.; Trabanco, A. A.; and Oehlrich, D.\n\n\n \n\n\n\n JOURNAL OF ORGANIC CHEMISTRY, 83(16): 9510-9516. AUG 17 2018.\n \n\n\n\n
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@article{ WOS:000442451500062,\nAuthor = {Wright, Miranda and Martinez-Lamenca, Carolina and Leenaerts, Joseph E.\n   and Brennan, Paul E. and Trabanco, Andres A. and Oehlrich, Daniel},\nTitle = {Bench-Stable Transfer Reagent Facilitates the Generation of\n   Trifluoromethyl-sulfonimidamides},\nJournal = {JOURNAL OF ORGANIC CHEMISTRY},\nYear = {2018},\nVolume = {83},\nNumber = {16},\nPages = {9510-9516},\nMonth = {AUG 17},\nDOI = {10.1021/acs.joc.8b01244},\nISSN = {0022-3263},\nORCID-Numbers = {Trabanco, Andres A./0000-0002-4225-758X\n   Brennan, Paul/0000-0002-8950-7646\n   Oehlrich, Daniel/0000-0002-3392-1952},\nUnique-ID = {WOS:000442451500062},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery of a novel allosteric inhibitor scaffold for polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2.\n \n \n \n\n\n \n Moustakim, M.; Riedel, K.; Schuller, M.; Gehring, A. P.; Monteiro, O. P.; Martin, S. P.; Fedorov, O.; Heer, J.; Dixon, D. J.; Elkins, J. M.; Knapp, S.; Bracher, F.; and Brennan, P. E.\n\n\n \n\n\n\n BIOORGANIC & MEDICINAL CHEMISTRY, 26(11): 2965-2972. JUL 15 2018.\n \n\n\n\n
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@article{ WOS:000434682900006,\nAuthor = {Moustakim, Moses and Riedel, Kerstin and Schuller, Marion and Gehring,\n   Andre P. and Monteiro, Octovia P. and Martin, Sarah P. and Fedorov, Oleg\n   and Heer, Jag and Dixon, Darren J. and Elkins, Jonathan M. and Knapp,\n   Stefan and Bracher, Franz and Brennan, Paul E.},\nTitle = {Discovery of a novel allosteric inhibitor scaffold for\n   polyadenosine-diphosphate-ribose polymerase 14 (PARP14) macrodomain 2},\nJournal = {BIOORGANIC \\& MEDICINAL CHEMISTRY},\nYear = {2018},\nVolume = {26},\nNumber = {11},\nPages = {2965-2972},\nMonth = {JUL 15},\nDOI = {10.1016/j.bmc.2018.03.020},\nISSN = {0968-0896},\nEISSN = {1464-3391},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Moustakim, Moses/LKM-9655-2024\n   Fedorov, Oleg/A-3201-2019\n   },\nORCID-Numbers = {Fedorov, Oleg/0000-0001-5268-6399\n   Brennan, Paul/0000-0002-8950-7646\n   Schuller, Marion/0000-0002-1551-0359\n   Moustakim, Moses/0000-0002-5006-5684},\nUnique-ID = {WOS:000434682900006},\n}\n\n
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\n \n\n \n \n \n \n \n Halogen-Aromatic Interactions Modulate Inhibitor Residence Times.\n \n \n \n\n\n \n Heroven, C.; Georgi, V.; Ganotra, G. K.; Brennan, P.; Wolfreys, F.; Wade, R. C.; Fernandez-Montalvan, A. E.; Chaikuad, A.; and Knapp, S.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57(24): 7220-7224. JUN 11 2018.\n \n\n\n\n
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@article{ WOS:000434350400045,\nAuthor = {Heroven, Christina and Georgi, Victoria and Ganotra, Gaurav K. and\n   Brennan, Paul and Wolfreys, Finn and Wade, Rebecca C. and\n   Fernandez-Montalvan, Amaury E. and Chaikuad, Apirat and Knapp, Stefan},\nTitle = {Halogen-Aromatic Interactions Modulate Inhibitor Residence Times},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2018},\nVolume = {57},\nNumber = {24},\nPages = {7220-7224},\nMonth = {JUN 11},\nDOI = {10.1002/anie.201801666},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Wade, Rebecca/L-1489-2019\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Chaikuad, Apirat/0000-0003-1120-2209\n   Heroven, Christina/0000-0001-9413-2108\n   Fernandez-Montalvan, Amaury/0000-0001-9156-0000\n   Ganotra, Gaurav Kumar/0000-0002-1791-1113},\nUnique-ID = {WOS:000434350400045},\n}\n\n
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\n \n\n \n \n \n \n \n Identifying Small-Molecule Binding Sites for Epigenetic Proteins at Domain-Domain Interfaces.\n \n \n \n\n\n \n Bowkett, D.; Talon, R.; Tallant, C.; Schofield, C.; von Delft, F.; Knapp, S.; Bruton, G.; and Brennan, P. E.\n\n\n \n\n\n\n CHEMMEDCHEM, 13(10): 1051-1057. MAY 23 2018.\n \n\n\n\n
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@article{ WOS:000434077400008,\nAuthor = {Bowkett, David and Talon, Romain and Tallant, Cynthia and Schofield,\n   Chris and von Delft, Frank and Knapp, Stefan and Bruton, Gordon and\n   Brennan, Paul E.},\nTitle = {Identifying Small-Molecule Binding Sites for Epigenetic Proteins at\n   Domain-Domain Interfaces},\nJournal = {CHEMMEDCHEM},\nYear = {2018},\nVolume = {13},\nNumber = {10},\nPages = {1051-1057},\nMonth = {MAY 23},\nDOI = {10.1002/cmdc.201800030},\nISSN = {1860-7179},\nEISSN = {1860-7187},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {von Delft, Frank/0000-0003-0378-0017\n   Schofield, Chris/0009-0008-4988-0199\n   Tallant, Cynthia/0000-0001-5645-435X\n   Talon, Romain/0000-0003-1123-7241\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000434077400008},\n}\n\n
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\n \n\n \n \n \n \n \n Mild, calcium catalysed Beckmann rearrangements.\n \n \n \n\n\n \n Kiely-Collins, H. J.; Sechi, I.; Brennan, P. E.; and McLaughlin, M. G.\n\n\n \n\n\n\n CHEMICAL COMMUNICATIONS, 54(6): 654-657. JAN 18 2018.\n \n\n\n\n
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@article{ WOS:000422861900019,\nAuthor = {Kiely-Collins, H. J. and Sechi, I. and Brennan, P. E. and McLaughlin, M.\n   G.},\nTitle = {Mild, calcium catalysed Beckmann rearrangements},\nJournal = {CHEMICAL COMMUNICATIONS},\nYear = {2018},\nVolume = {54},\nNumber = {6},\nPages = {654-657},\nMonth = {JAN 18},\nDOI = {10.1039/c7cc09491d},\nISSN = {1359-7345},\nEISSN = {1364-548X},\nResearcherID-Numbers = {McLaughlin, Mark/N-8192-2019\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Kiely-Collins, Hannah/0000-0002-6258-5484\n   McLaughlin, Mark/0000-0002-5999-4703},\nUnique-ID = {WOS:000422861900019},\n}\n\n
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\n \n\n \n \n \n \n \n Target Identification Using Chemical Probes.\n \n \n \n\n\n \n Moustakim, M.; Felce, S. L.; Zaarour, N.; Farnie, G.; McCann, F. E.; and Brennan, P. E.\n\n\n \n\n\n\n In Lesburg, C., editor(s), MODERN APPROACHES IN DRUG DISCOVERY, volume 610, of Methods in Enzymology, pages 27-58. 2018.\n \n\n\n\n
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@incollection{ WOS:000452354600003,\nAuthor = {Moustakim, Moses and Felce, Suet Ling and Zaarour, Nancy and Farnie,\n   Gillian and McCann, Fiona E. and Brennan, Paul E.},\nEditor = {Lesburg, CA},\nTitle = {Target Identification Using Chemical Probes},\nBooktitle = {MODERN APPROACHES IN DRUG DISCOVERY},\nSeries = {Methods in Enzymology},\nYear = {2018},\nVolume = {610},\nPages = {27-58},\nDOI = {10.1016/bs.mie.2018.09.013},\nISSN = {0076-6879},\nISBN = {978-0-12-815383-3},\nResearcherID-Numbers = {Moustakim, Moses/LKM-9655-2024\n   farnie, gillian/GLT-8777-2022\n   },\nORCID-Numbers = {Felce, Ling/0000-0001-8534-1629\n   McCann, Fiona/0000-0001-8151-8781\n   Farnie, Gillian/0000-0002-1407-2529},\nUnique-ID = {WOS:000452354600003},\n}\n\n
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\n \n\n \n \n \n \n \n Principles and Applications of Fragment-based Drug Discovery for Chemical Probes.\n \n \n \n\n\n \n Moustakim, M.; and Brennan, P. E.\n\n\n \n\n\n\n In Westwood, N.; and Nelson, A, editor(s), CHEMICAL AND BIOLOGICAL SYNTHESIS: ENABLING APPROACHES FOR UNDERSTANDING BIOLOGY, volume 10, of Chemical Biology, pages 114-137. 2018.\n \n\n\n\n
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@incollection{ WOS:000568594300005,\nAuthor = {Moustakim, Moses and Brennan, Paul E.},\nEditor = {Westwood, NJ and Nelson, A},\nTitle = {Principles and Applications of Fragment-based Drug Discovery for\n   Chemical Probes},\nBooktitle = {CHEMICAL AND BIOLOGICAL SYNTHESIS: ENABLING APPROACHES FOR UNDERSTANDING\n   BIOLOGY},\nSeries = {Chemical Biology},\nYear = {2018},\nVolume = {10},\nPages = {114-137},\nISSN = {2055-1975},\nISBN = {978-1-78801-280-5; 978-1-78262-948-1},\nResearcherID-Numbers = {Moustakim, Moses/LKM-9655-2024},\nUnique-ID = {WOS:000568594300005},\n}\n\n
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\n  \n 2017\n \n \n (12)\n \n \n
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\n \n\n \n \n \n \n \n Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.\n \n \n \n\n\n \n Gerken, P. A.; Wolstenhulme, J. R.; Tumber, A.; Hatch, S. B.; Zhang, Y.; Mueller, S.; Chandler, S. A.; Mair, B.; Li, F.; Nijman, S. M. B.; Konietzny, R.; Szommer, T.; Yapp, C.; Fedorov, O.; Benesch, J. L. P.; Vedadi, M.; Kessler, B. M.; Kawamura, A.; Brennan, P. E.; and Smith, M. D.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(49): 15555-15559. DEC 4 2017.\n \n\n\n\n
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@article{ WOS:000416244200008,\nAuthor = {Gerken, Philip A. and Wolstenhulme, Jamie R. and Tumber, Anthony and\n   Hatch, Stephanie B. and Zhang, Yijia and Mueller, Susanne and Chandler,\n   Shane A. and Mair, Barbara and Li, Fengling and Nijman, Sebastian M. B.\n   and Konietzny, Rebecca and Szommer, Tamas and Yapp, Clarence and\n   Fedorov, Oleg and Benesch, Justin L. P. and Vedadi, Masoud and Kessler,\n   Benedikt M. and Kawamura, Akane and Brennan, Paul E. and Smith, Martin\n   D.},\nTitle = {Discovery of a Highly Selective Cell-Active Inhibitor of the Histone\n   Lysine Demethylases KDM2/7},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2017},\nVolume = {56},\nNumber = {49},\nPages = {15555-15559},\nMonth = {DEC 4},\nDOI = {10.1002/anie.201706788},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nResearcherID-Numbers = {Li, Xiaotian/ABI-3309-2020\n   Smith, Martin/W-3914-2019\n   Benesch, Justin/A-4250-2008\n   Fedorov, Oleg/A-3201-2019\n   Knapp, Stefan/AAG-2347-2019\n   Kessler, Benedikt/JGC-6978-2023\n   Kawamura, Akane/I-4047-2018\n   },\nORCID-Numbers = {Kessler, Benedikt/0000-0002-8160-2446\n   Mair, Barbara/0000-0001-6982-2529\n   Brennan, Paul/0000-0002-8950-7646\n   Fedorov, Oleg/0000-0001-5268-6399\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Hatch, Stephanie/0000-0002-7401-9279\n   Kawamura, Akane/0000-0003-1169-5082\n   Szommer, Tamas/0000-0002-3811-4068},\nUnique-ID = {WOS:000416244200008},\n}\n\n
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\n \n\n \n \n \n \n \n Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.\n \n \n \n\n\n \n Meier, J. C.; Tallant, C.; Fedorov, O.; Witwicka, H.; Hwang, S.; van Stiphout, R. G.; Lambert, J.; Rogers, C.; Yapp, C.; Gerstenberger, B. S.; Fedele, V.; Savitsky, P.; Heidenreich, D.; Daniels, D. L.; Owen, D. R.; Fish, P. V.; Igoe, N. M.; Bayle, E. D.; Haendler, B.; Oppermann, U. C. T.; Buffa, F.; Brennan, P. E.; Mueller, S.; Gingras, A. C.; Odgren, P. R.; Birnbaum, M. J.; and Knapp, S.\n\n\n \n\n\n\n ACS CHEMICAL BIOLOGY, 12(10): 2619-2630. OCT 2017.\n \n\n\n\n
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@article{ WOS:000413709700020,\nAuthor = {Meier, Julia C. and Tallant, Cynthia and Fedorov, Oleg and Witwicka,\n   Hanna and Hwang, Sung-Yong and van Stiphout, Ruud G. and Lambert,\n   Jean-Philippe and Rogers, Catherine and Yapp, Clarence and\n   Gerstenberger, Brian S. and Fedele, Vita and Savitsky, Pavel and\n   Heidenreich, David and Daniels, Danette L. and Owen, Dafydd R. and Fish,\n   Paul V. and Igoe, Niall M. and Bayle, Elliott D. and Haendler, Bernard\n   and Oppermann, Udo C. T. and Buffa, Francesca and Brennan, Paul E. and\n   Mueller, Susanne and Gingras, Anne Claude and Odgren, Paul R. and\n   Birnbaum, Mark J. and Knapp, Stefan},\nTitle = {Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers\n   Family Impairs Osteoclast Differentiation},\nJournal = {ACS CHEMICAL BIOLOGY},\nYear = {2017},\nVolume = {12},\nNumber = {10},\nPages = {2619-2630},\nMonth = {OCT},\nDOI = {10.1021/acschembio.7b00481},\nISSN = {1554-8929},\nEISSN = {1554-8937},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Fedorov, Oleg/A-3201-2019\n   Buffa, Francesca/D-2574-2013\n   Gingras, Anne-Claude/E-9982-2010\n   },\nORCID-Numbers = {Bayle, Elliott D./0000-0002-7089-3858\n   Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Fedorov, Oleg/0000-0001-5268-6399\n   Lambert, Jean-Philippe/0000-0002-0833-1221\n   Knapp, Stefan/0000-0001-5995-6494\n   Gingras, Anne-Claude/0000-0002-6090-4437\n   Tallant, Cynthia/0000-0001-5645-435X\n   Heidenreich, David/0000-0003-2806-8835\n   Savitsky, Pavel/0000-0001-8584-7750},\nUnique-ID = {WOS:000413709700020},\n}\n\n
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\n \n\n \n \n \n \n \n Design of a Chemical Probe for the Bromodomain and Plant Homeodomain Finger-Containing (BRPF) Family of Proteins.\n \n \n \n\n\n \n Igoe, N.; Bayle, E. D.; Tallant, C.; Fedorov, O.; Meier, J. C.; Savitsky, P.; Rogers, C.; Morias, Y.; Scholze, S.; Boyd, H.; Cunoosarny, D.; Andrews, D. M.; Cheasty, A.; Brennan, P. E.; Mueller, S.; Knapp, S.; and Fish, P. V.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 60(16): 6998-7011. AUG 24 2017.\n \n\n\n\n
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@article{ WOS:000408598500012,\nAuthor = {Igoe, Niall and Bayle, Elliott D. and Tallant, Cynthia and Fedorov, Oleg\n   and Meier, Julia C. and Savitsky, Pavel and Rogers, Catherine and\n   Morias, Yannick and Scholze, Sarah and Boyd, Helen and Cunoosarny, Danen\n   and Andrews, David M. and Cheasty, Anne and Brennan, Paul E. and\n   Mueller, Susanne and Knapp, Stefan and Fish, Paul V.},\nTitle = {Design of a Chemical Probe for the Bromodomain and Plant Homeodomain\n   Finger-Containing (BRPF) Family of Proteins},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2017},\nVolume = {60},\nNumber = {16},\nPages = {6998-7011},\nMonth = {AUG 24},\nDOI = {10.1021/acs.jmedchem.7b00611},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Fedorov, Oleg/A-3201-2019\n   },\nORCID-Numbers = {Bayle, Elliott D./0000-0002-7089-3858\n   Fedorov, Oleg/0000-0001-5268-6399\n   Tallant, Cynthia/0000-0001-5645-435X\n   Savitsky, Pavel/0000-0001-8584-7750\n   Brennan, Paul/0000-0002-8950-7646\n   Knapp, Stefan/0000-0001-5995-6494\n   Andrews, David/0000-0002-6716-6270},\nUnique-ID = {WOS:000408598500012},\n}\n\n
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\n \n\n \n \n \n \n \n BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis.\n \n \n \n\n\n \n Roberts, T. C.; Etxaniz, U.; Dall'Agnese, A.; Wu, S.; Chiang, C.; Brennan, P. E.; Wood, M. J. A.; and Puri, P. L.\n\n\n \n\n\n\n SCIENTIFIC REPORTS, 7. JUL 21 2017.\n \n\n\n\n
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@article{ WOS:000406285700061,\nAuthor = {Roberts, Thomas C. and Etxaniz, Usue and Dall'Agnese, Alessandra and Wu,\n   Shwu-Yuan and Chiang, Cheng-Ming and Brennan, Paul E. and Wood, Matthew\n   J. A. and Puri, Pier Lorenzo},\nTitle = {BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal\n   Myogenesis},\nJournal = {SCIENTIFIC REPORTS},\nYear = {2017},\nVolume = {7},\nMonth = {JUL 21},\nDOI = {10.1038/s41598-017-06483-7},\nArticle-Number = {6153},\nISSN = {2045-2322},\nResearcherID-Numbers = {Wood, Matthew/HDN-1469-2022\n   Roberts, Thomas/AAI-3183-2020\n   Puri, Pankaj/KYQ-4180-2024\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Wood, Matthew/0000-0002-5436-6011},\nUnique-ID = {WOS:000406285700061},\n}\n\n
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\n \n\n \n \n \n \n \n Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.\n \n \n \n\n\n \n Denny, R. A.; Flick, A. C.; Coe, J.; Langille, J.; Basak, A.; Liu, S.; Stock, I.; Sahasrabudhe, P.; Bonin, P.; Hay, D. A.; Brennan, P. E.; Pletcher, M.; Jones, L. H.; and Chekler, E. L. P.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 60(13): 5349-5363. JUL 13 2017.\n \n\n\n\n
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@article{ WOS:000405764900007,\nAuthor = {Denny, R. Aldrin and Flick, Andrew C. and Coe, Jotham and Langille,\n   Jonathan and Basak, Arindrajit and Liu, Shenping and Stock, Ingrid and\n   Sahasrabudhe, Parag and Bonin, Paul and Hay, Duncan A. and Brennan, Paul\n   E. and Pletcher, Mathew and Jones, Lyn H. and Chekler, Eugene L.\n   Piatnitski},\nTitle = {Structure-Based Design of Highly Selective Inhibitors of the CREB\n   Binding Protein Bromodomain},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2017},\nVolume = {60},\nNumber = {13},\nPages = {5349-5363},\nMonth = {JUL 13},\nDOI = {10.1021/acs.jmedchem.6b01839},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Jones, Lyn/HPG-6706-2023\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Jones, Lyn/0000-0002-8388-5865},\nUnique-ID = {WOS:000405764900007},\n}\n\n
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\n \n\n \n \n \n \n \n Di-iodotyrosinated peptide imaging of cartilage (DIPIC).\n \n \n \n\n\n \n Fowkes, M. M.; Borges, P. d. N.; Brennan, P. E.; Vincent, T. L.; and Lim, N. H.\n\n\n \n\n\n\n INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 98(3): A7. JUN 2017.\n Spring Meeting of the British-Society-for-Matrix-Biology (BSMB), Univ Oxford, Oxford, ENGLAND, APR 03-04, 2017\n\n\n\n
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@article{ WOS:000408620000013,\nAuthor = {Fowkes, M. M. and Borges, P. das Neves and Brennan, P. E. and Vincent,\n   T. L. and Lim, N. H.},\nTitle = {Di-iodotyrosinated peptide imaging of cartilage (DIPIC)},\nJournal = {INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY},\nYear = {2017},\nVolume = {98},\nNumber = {3},\nPages = {A7},\nMonth = {JUN},\nNote = {Spring Meeting of the British-Society-for-Matrix-Biology (BSMB), Univ\n   Oxford, Oxford, ENGLAND, APR 03-04, 2017},\nOrganization = {British Soc Matrix Biol},\nISSN = {0959-9673},\nEISSN = {1365-2613},\nResearcherID-Numbers = {Lim, Ngee/B-4226-2011\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000408620000013},\n}\n\n
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\n \n\n \n \n \n \n \n Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.\n \n \n \n\n\n \n Kawamura, A.; Muenzel, M.; Kojima, T.; Yapp, C.; Bhushan, B.; Goto, Y.; Tumber, A.; Katoh, T.; King, O. N. F.; Passioura, T.; Walport, L. J.; Hatch, S. B.; Madden, S.; Mueller, S.; Brennan, P. E.; Chowdhury, R.; Hopkinson, R. J.; Suga, H.; and Schofield, C. J.\n\n\n \n\n\n\n NATURE COMMUNICATIONS, 8. APR 6 2017.\n \n\n\n\n
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@article{ WOS:000398410700001,\nAuthor = {Kawamura, Akane and Muenzel, Martin and Kojima, Tatsuya and Yapp,\n   Clarence and Bhushan, Bhaskar and Goto, Yuki and Tumber, Anthony and\n   Katoh, Takayuki and King, Oliver N. F. and Passioura, Toby and Walport,\n   Louise J. and Hatch, Stephanie B. and Madden, Sarah and Mueller, Susanne\n   and Brennan, Paul E. and Chowdhury, Rasheduzzaman and Hopkinson, Richard\n   J. and Suga, Hiroaki and Schofield, Christopher J.},\nTitle = {Highly selective inhibition of histone demethylases by de novo\n   macrocyclic peptides},\nJournal = {NATURE COMMUNICATIONS},\nYear = {2017},\nVolume = {8},\nMonth = {APR 6},\nDOI = {10.1038/ncomms14773},\nArticle-Number = {14773},\nISSN = {2041-1723},\nResearcherID-Numbers = {Walport, Louise/ABB-3578-2020\n   Muenzel, Martin/B-3360-2011\n   Knapp, Stefan/AAG-2347-2019\n   Bhushan, Bharat/G-3530-2016\n   GOTO, YUKI/G-5037-2014\n   Chowdhury, Rasheduzzaman/I-7697-2014\n   Hopkinson, Richard/K-8372-2013\n   Kawamura, Akane/I-4047-2018\n   },\nORCID-Numbers = {Katoh, Takayuki/0000-0001-6550-6203\n   Hatch, Stephanie/0000-0002-7401-9279\n   Chowdhury, Rasheduzzaman/0000-0002-8058-6149\n   Schofield, Christopher/0000-0002-0290-6565\n   Passioura, Toby/0000-0002-6089-5067\n   Madden, Sarah/0000-0001-6858-7651\n   Bhushan, Bhaskar/0000-0001-6136-8616\n   King, Oliver/0000-0002-6152-7207\n   Schofield, Chris/0009-0008-4988-0199\n   Hopkinson, Richard/0000-0001-7610-8163\n   Kawamura, Akane/0000-0003-1169-5082\n   Brennan, Paul/0000-0002-8950-7646\n   Muenzel, Martin/0000-0002-4504-8281\n   Muller-Knapp, Susanne/0000-0003-2402-4157},\nUnique-ID = {WOS:000398410700001},\n}\n\n
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\n \n\n \n \n \n \n \n Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.\n \n \n \n\n\n \n Tumber, A.; Nuzzi, A.; Hookway, E. S.; Hatch, S. B.; Velupillai, S.; Johansson, C.; Kawamura, A.; Savitsky, P.; Yapp, C.; Szykowska, A.; Wu, N.; Bountra, C.; Strain-Damerell, C.; Burgess-Brown, N. A.; Ruda, G. F.; Fedorov, O.; Munro, S.; England, K. S.; Nowak, R. P.; Schofield, C. J.; La Thangue, N. B.; Pawlyn, C.; Davies, F.; Morgan, G.; Athanasou, N.; Mueller, S.; Oppermann, U.; and Brennan, P. E.\n\n\n \n\n\n\n CELL CHEMICAL BIOLOGY, 24(3): 371-380. MAR 16 2017.\n \n\n\n\n
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@article{ WOS:000397424600014,\nAuthor = {Tumber, Anthony and Nuzzi, Andrea and Hookway, Edward S. and Hatch,\n   Stephanie B. and Velupillai, Srikannathasan and Johansson, Catrine and\n   Kawamura, Akane and Savitsky, Pavel and Yapp, Clarence and Szykowska,\n   Aleksandra and Wu, Na and Bountra, Chas and Strain-Damerell, Claire and\n   Burgess-Brown, Nicola A. and Ruda, Gian Filippo and Fedorov, Oleg and\n   Munro, Shonagh and England, Katherine S. and Nowak, Radoslaw P. and\n   Schofield, Christopher J. and La Thangue, Nicholas B. and Pawlyn,\n   Charlotte and Davies, Faith and Morgan, Gareth and Athanasou, Nick and\n   Mueller, Susanne and Oppermann, Udo and Brennan, Paul E.},\nTitle = {Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of\n   H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma\n   Cells},\nJournal = {CELL CHEMICAL BIOLOGY},\nYear = {2017},\nVolume = {24},\nNumber = {3},\nPages = {371-380},\nMonth = {MAR 16},\nDOI = {10.1016/j.chembiol.2017.02.006},\nISSN = {2451-9448},\nResearcherID-Numbers = {Fedorov, Oleg/A-3201-2019\n   Morgan, Gareth/G-3603-2010\n   Hookway, Edward/I-2613-2018\n   Nowak, Radosław/JLM-2338-2023\n   Knapp, Stefan/AAG-2347-2019\n   Kawamura, Akane/I-4047-2018\n   },\nORCID-Numbers = {England, Katherine/0000-0002-4921-7505\n   Schofield, Christopher/0000-0002-0290-6565\n   Fedorov, Oleg/0000-0001-5268-6399\n   Hatch, Stephanie/0000-0002-7401-9279\n   Pawlyn, Charlotte/0000-0002-7190-0028\n   Davies, Faith/0000-0002-3971-2393\n   Schofield, Chris/0009-0008-4988-0199\n   Savitsky, Pavel/0000-0001-8584-7750\n   Kawamura, Akane/0000-0003-1169-5082\n   Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   morgan, gareth/0000-0002-4271-6360\n   Ruda, Gian Filippo/0000-0001-6150-2715\n   Nowak, Radoslaw/0000-0002-0605-0071},\nUnique-ID = {WOS:000397424600014},\n}\n\n
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\n \n\n \n \n \n \n \n Assessing histone demethylase inhibitors in cells: lessons learned.\n \n \n \n\n\n \n Hatch, S. B.; Yapp, C.; Montenegro, R. C.; Savitsky, P.; Gamble, V.; Tumber, A.; Ruda, G. F.; Bavetsias, V.; Fedorov, O.; Atrash, B.; Raynaud, F.; Lanigan, R.; Carmichael, L.; Tomlin, K.; Burke, R.; Westaway, S. M.; Brown, J. A.; Prinjha, R. K.; Martinez, E. D.; Oppermann, U.; Schofield, C. J.; Bountra, C.; Kawamura, A.; Blagg, J.; Brennan, P. E.; Rossanese, O.; and Mueller, S.\n\n\n \n\n\n\n EPIGENETICS & CHROMATIN, 10. MAR 1 2017.\n \n\n\n\n
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@article{ WOS:000395485100001,\nAuthor = {Hatch, Stephanie B. and Yapp, Clarence and Montenegro, Raquel C. and\n   Savitsky, Pavel and Gamble, Vicki and Tumber, Anthony and Ruda, Gian\n   Filippo and Bavetsias, Vassilios and Fedorov, Oleg and Atrash, Butrus\n   and Raynaud, Florence and Lanigan, Rachel and Carmichael, LeAnne and\n   Tomlin, Kathy and Burke, Rosemary and Westaway, Susan M. and Brown, Jack\n   A. and Prinjha, Rab K. and Martinez, Elisabeth D. and Oppermann, Udo and\n   Schofield, Christopher J. and Bountra, Chas and Kawamura, Akane and\n   Blagg, Julian and Brennan, Paul E. and Rossanese, Olivia and Mueller,\n   Susanne},\nTitle = {Assessing histone demethylase inhibitors in cells: lessons learned},\nJournal = {EPIGENETICS \\& CHROMATIN},\nYear = {2017},\nVolume = {10},\nMonth = {MAR 1},\nDOI = {10.1186/s13072-017-0116-6},\nArticle-Number = {9},\nISSN = {1756-8935},\nResearcherID-Numbers = {Fedorov, Oleg/A-3201-2019\n   Montenegro, Raquel/I-1260-2013\n   Knapp, Stefan/AAG-2347-2019\n   Lanigan, Rachel/B-4830-2015\n   Kawamura, Akane/I-4047-2018\n   },\nORCID-Numbers = {Ruda, Gian Filippo/0000-0001-6150-2715\n   Rossanese, Olivia/0000-0002-1262-9522\n   Fedorov, Oleg/0000-0001-5268-6399\n   Savitsky, Pavel/0000-0001-8584-7750\n   Kawamura, Akane/0000-0003-1169-5082\n   Schofield, Christopher/0000-0002-0290-6565\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Brennan, Paul/0000-0002-8950-7646\n   Montenegro, Raquel/0000-0002-3861-293X\n   Schofield, Chris/0009-0008-4988-0199\n   Hatch, Stephanie/0000-0002-7401-9279\n   Raynaud, Florence/0000-0003-0957-6279\n   Carmichael, LeAnne/0000-0003-3362-0276},\nUnique-ID = {WOS:000395485100001},\n}\n\n
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\n \n\n \n \n \n \n \n Design of a Biased Potent Small Molecule Inhibitor of the Bromodonnain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.\n \n \n \n\n\n \n Igoe, N.; Bayle, E. D.; Fedorov, O.; Tallant, C.; Savitsky, P.; Rogers, C.; Owen, D. R.; Deb, G.; Somervaille, T. C. P.; Andrews, D. M.; Jones, N.; Cheasty, A.; Ryder, H.; Brennan, P. E.; Mueller, S.; Knapp, S.; and Fish, P. V.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 60(2): 668-680. JAN 26 2017.\n \n\n\n\n
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@article{ WOS:000393009500010,\nAuthor = {Igoe, Niall and Bayle, Elliott D. and Fedorov, Oleg and Tallant, Cynthia\n   and Savitsky, Pavel and Rogers, Catherine and Owen, Dafydd R. and Deb,\n   Gauri and Somervaille, Tim C. P. and Andrews, David M. and Jones, Neil\n   and Cheasty, Anne and Ryder, Hamish and Brennan, Paul E. and Mueller,\n   Susanne and Knapp, Stefan and Fish, Paul V.},\nTitle = {Design of a Biased Potent Small Molecule Inhibitor of the Bromodonnain\n   and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in\n   Vivo Studies},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2017},\nVolume = {60},\nNumber = {2},\nPages = {668-680},\nMonth = {JAN 26},\nDOI = {10.1021/acs.jmedchem.6b01583},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Fedorov, Oleg/A-3201-2019\n   Deb, Gauri/T-8429-2019\n   Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {Muller-Knapp, Susanne/0000-0003-2402-4157\n   Bayle, Elliott D./0000-0002-7089-3858\n   Brennan, Paul/0000-0002-8950-7646\n   Andrews, David/0000-0002-6716-6270\n   Tallant, Cynthia/0000-0001-5645-435X\n   Fedorov, Oleg/0000-0001-5268-6399\n   Savitsky, Pavel/0000-0001-8584-7750},\nUnique-ID = {WOS:000393009500010},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery of a PCAF Bromodomain Chemical Probe.\n \n \n \n\n\n \n Moustakim, M.; Clark, P. G. K.; Trulli, L.; de Arriba, A. L. F.; Ehebauer, M. T.; Chaikuad, A.; Murphy, E. J.; Mendez-Johnson, J.; Daniels, D.; Hou, C. D.; Lin, Y.; Walker, J. R.; Hui, R.; Yang, H.; Dorrell, L.; Rogers, C. M.; Monteiro, O. P.; Fedorov, O.; Huber, K. V. M.; Knapp, S.; Heer, J.; Dixon, D. J.; and Brennan, P. E.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(3): 827-831. JAN 16 2017.\n \n\n\n\n
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@article{ WOS:000394996900027,\nAuthor = {Moustakim, Moses and Clark, Peter G. K. and Trulli, Laura and de Arriba,\n   Angel L. Fuentes and Ehebauer, Matthias T. and Chaikuad, Apirat and\n   Murphy, Emma J. and Mendez-Johnson, Jacqui and Daniels, Danette and Hou,\n   Chun-Feng D. and Lin, Yu-Hui and Walker, John R. and Hui, Raymond and\n   Yang, Hongbing and Dorrell, Lucy and Rogers, Catherine M. and Monteiro,\n   Octovia P. and Fedorov, Oleg and Huber, Kilian V. M. and Knapp, Stefan\n   and Heer, Jag and Dixon, Darren J. and Brennan, Paul E.},\nTitle = {Discovery of a PCAF Bromodomain Chemical Probe},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2017},\nVolume = {56},\nNumber = {3},\nPages = {827-831},\nMonth = {JAN 16},\nDOI = {10.1002/anie.201610816},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nResearcherID-Numbers = {Moustakim, Moses/LKM-9655-2024\n   Knapp, Stefan/AAG-2347-2019\n   Fedorov, Oleg/A-3201-2019\n   Huber, Kilian/L-6921-2015\n   Fuentes de Arriba, Angel Luis/J-8201-2014\n   },\nORCID-Numbers = {Murphy, Emma/0000-0003-4551-8068\n   /0000-0002-5255-895X\n   Knapp, Stefan/0000-0001-5995-6494\n   Chaikuad, Apirat/0000-0003-1120-2209\n   Huber, Kilian/0000-0002-1103-5300\n   Ehebauer, Matthias/0000-0002-3148-8390\n   Fedorov, Oleg/0000-0001-5268-6399\n   Moustakim, Moses/0000-0002-5006-5684\n   Fuentes de Arriba, Angel Luis/0000-0001-7424-8146\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000394996900027},\n}\n\n
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\n \n\n \n \n \n \n \n The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.\n \n \n \n\n\n \n Bradley, A. R.; Echalier, A.; Fairhead, M.; Strain-Damerell, C.; Brennan, P.; Bullock, A. N.; Burgess-Brown, N. A.; Carpenter, E. P.; Gileadi, O.; Marsden, B. D.; Lee, W. H.; Yue, W.; Bountra, C.; and von Delft, F.\n\n\n \n\n\n\n In VanMontfort, R.; and Workman, P, editor(s), STRUCTURE-BASED DRUG DESIGN: INSIGHTS FROM ACADEMIA AND INDUSTRY, volume 61, of Essays in Biochemistry, pages 495-503. 2017.\n \n\n\n\n
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@incollection{ WOS:000450231200007,\nAuthor = {Bradley, Anthony R. and Echalier, Aude and Fairhead, Michael and\n   Strain-Damerell, Claire and Brennan, Paul and Bullock, Alex N. and\n   Burgess-Brown, Nicola A. and Carpenter, Elisabeth P. and Gileadi, Opher\n   and Marsden, Brian D. and Lee, Wen Hwa and Yue, Wyatt and Bountra, Chas\n   and von Delft, Frank},\nEditor = {VanMontfort, RLM and Workman, P},\nTitle = {The SGC beyond structural genomics: redefining the role of 3D structures\n   by coupling genomic stratification with fragment-based discovery},\nBooktitle = {STRUCTURE-BASED DRUG DESIGN: INSIGHTS FROM ACADEMIA AND INDUSTRY},\nSeries = {Essays in Biochemistry},\nYear = {2017},\nVolume = {61},\nNumber = {5},\nPages = {495-503},\nDOI = {10.1042/EBC20170051},\nISSN = {0071-1365},\nEISSN = {1744-1358},\nResearcherID-Numbers = {Lee, Wen Hwa/GZA-8183-2022\n   Gileadi, Opher/F-1105-2013\n   Echalier, Aude/JDM-4324-2023\n   Lee, Wen Hwa/G-1250-2013\n   },\nORCID-Numbers = {Yue, Wyatt/0000-0001-6959-6007\n   Brennan, Paul/0000-0002-8950-7646\n   Lee, Wen Hwa/0000-0002-4098-5225\n   Carpenter, Liz/0000-0001-9138-2937\n   Fairhead, Michael/0000-0001-5361-3933\n   von Delft, Frank/0000-0003-0378-0017},\nUnique-ID = {WOS:000450231200007},\n}\n\n
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\n \n\n \n \n \n \n \n Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors.\n \n \n \n\n\n \n Popp, T. A.; Tallant, C.; Rogers, C.; Fedorov, O.; Brennan, P. E.; Mueller, S.; Knapp, S.; and Bracher, F.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 59(19): 8889-8912. OCT 13 2016.\n \n\n\n\n
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@article{ WOS:000385607100015,\nAuthor = {Popp, Tobias A. and Tallant, Cynthia and Rogers, Catherine and Fedorov,\n   Oleg and Brennan, Paul E. and Mueller, Susanne and Knapp, Stefan and\n   Bracher, Franz},\nTitle = {Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2016},\nVolume = {59},\nNumber = {19},\nPages = {8889-8912},\nMonth = {OCT 13},\nDOI = {10.1021/acs.jmedchem.6b00774},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Fedorov, Oleg/B-6412-2014\n   Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Knapp, Stefan/0000-0001-5995-6494\n   Tallant, Cynthia/0000-0001-5645-435X},\nUnique-ID = {WOS:000385607100015},\n}\n\n
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\n \n\n \n \n \n \n \n Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.\n \n \n \n\n\n \n Picaud, S.; Leonards, K.; Lambert, J.; Dovey, O.; Wells, C.; Fedorov, O.; Monteiro, O.; Fujisawa, T.; Wang, C.; Lingard, H.; Tallant, C.; Nikbin, N.; Guetzoyan, L.; Ingham, R.; Ley, S. V.; Brennan, P.; Muller, S.; Samsonova, A.; Gingras, A.; Schwaller, J.; Vassiliou, G.; Knapp, S.; and Filippakopoulos, P.\n\n\n \n\n\n\n SCIENCE ADVANCES, 2(10). OCT 2016.\n \n\n\n\n
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@article{ WOS:000387991500017,\nAuthor = {Picaud, Sarah and Leonards, Katharina and Lambert, Jean-Philippe and\n   Dovey, Oliver and Wells, Christopher and Fedorov, Oleg and Monteiro,\n   Octovia and Fujisawa, Takao and Wang, Chen-Yi and Lingard, Hannah and\n   Tallant, Cynthia and Nikbin, Nikzad and Guetzoyan, Lucie and Ingham,\n   Richard and Ley, Steven V. and Brennan, Paul and Muller, Susanne and\n   Samsonova, Anastasia and Gingras, Anne-Claude and Schwaller, Juerg and\n   Vassiliou, George and Knapp, Stefan and Filippakopoulos, Panagis},\nTitle = {Promiscuous targeting of bromodomains by bromosporine identifies BET\n   proteins as master regulators of primary transcription response in\n   leukemia},\nJournal = {SCIENCE ADVANCES},\nYear = {2016},\nVolume = {2},\nNumber = {10},\nMonth = {OCT},\nDOI = {10.1126/sciadv.1600760},\nArticle-Number = {e1600760},\nISSN = {2375-2548},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Ley, Steven/O-7712-2016\n   Samsonova, Anastasia/AAU-7269-2021\n   Schwaller, Juerg/A-3044-2016\n   Samsonova, Anastasia/Q-7591-2016\n   Gingras, Anne-Claude/E-9982-2010\n   },\nORCID-Numbers = {Lambert, Jean-Philippe/0000-0002-0833-1221\n   Vassiliou, George/0000-0003-4337-8022\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Knapp, Stefan/0000-0001-5995-6494\n   Fujisawa, Takao/0000-0001-7401-5457\n   Wells-Holland, Chris/0000-0001-9985-9816\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Samsonova, Anastasia/0000-0002-9353-9173\n   Lingard, Hannah/0000-0003-2571-2496\n   Fedorov, Oleg/0000-0002-8662-7300\n   Gingras, Anne-Claude/0000-0002-6090-4437\n   Tallant, Cynthia/0000-0001-5645-435X},\nUnique-ID = {WOS:000387991500017},\n}\n\n
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\n \n\n \n \n \n \n \n Exploring the role of water in molecular recognition: predicting protein ligandability using a combinatorial search of surface hydration sites.\n \n \n \n\n\n \n Vukovic, S.; Brennan, P. E.; and Huggins, D. J.\n\n\n \n\n\n\n JOURNAL OF PHYSICS-CONDENSED MATTER, 28(34). SEP 1 2016.\n \n\n\n\n
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@article{ WOS:000379555600008,\nAuthor = {Vukovic, Sinisa and Brennan, Paul E. and Huggins, David J.},\nTitle = {Exploring the role of water in molecular recognition: predicting protein\n   ligandability using a combinatorial search of surface hydration sites},\nJournal = {JOURNAL OF PHYSICS-CONDENSED MATTER},\nYear = {2016},\nVolume = {28},\nNumber = {34},\nMonth = {SEP 1},\nDOI = {10.1088/0953-8984/28/34/344007},\nArticle-Number = {344007},\nISSN = {0953-8984},\nEISSN = {1361-648X},\nResearcherID-Numbers = {Huggins, David/B-5511-2012\n   Vukovic, Sinisa/J-3106-2013\n   },\nORCID-Numbers = {Vukovic, Sinisa/0000-0002-7682-0705\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000379555600008},\n}\n\n
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\n \n\n \n \n \n \n \n Advances and challenges in understanding histone demethylase biology.\n \n \n \n\n\n \n Nowak, R. P.; Tumber, A.; Johansson, C.; Che, K. H.; Brennan, P.; Owen, D.; and Oppermann, U.\n\n\n \n\n\n\n CURRENT OPINION IN CHEMICAL BIOLOGY, 33: 151-159. AUG 2016.\n \n\n\n\n
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@article{ WOS:000383937200022,\nAuthor = {Nowak, Radoslaw P. and Tumber, Anthony and Johansson, Catrine and Che,\n   Ka Hing and Brennan, Paul and Owen, Dafydd and Oppermann, Udo},\nTitle = {Advances and challenges in understanding histone demethylase biology},\nJournal = {CURRENT OPINION IN CHEMICAL BIOLOGY},\nYear = {2016},\nVolume = {33},\nPages = {151-159},\nMonth = {AUG},\nDOI = {10.1016/j.cbpa.2016.06.021},\nISSN = {1367-5931},\nEISSN = {1879-0402},\nResearcherID-Numbers = {Nowak, Radosław/JLM-2338-2023\n   },\nORCID-Numbers = {Nowak, Radoslaw/0000-0002-0605-0071\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000383937200022},\n}\n\n
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\n \n\n \n \n \n \n \n BET inhibition as a new strategy for the treatment of gastric cancer.\n \n \n \n\n\n \n Montenegro, R. C.; Clark, P. G. K.; Howarth, A.; Wan, X.; Ceroni, A.; Siejka, P.; Nunez-Alonso, G. A.; Monteiro, O.; Rogers, C.; Gamble, V.; Burbano, R.; Brennan, P. E.; Tallant, C.; Ebner, D.; Fedorov, O.; O'Neill, E.; Knapp, S.; Dixon, D.; and Muller, S.\n\n\n \n\n\n\n ONCOTARGET, 7(28): 43997-44012. JUL 12 2016.\n \n\n\n\n
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@article{ WOS:000385395700084,\nAuthor = {Montenegro, Raquel C. and Clark, Peter G. K. and Howarth, Alison and\n   Wan, Xiao and Ceroni, Alessandro and Siejka, Paulina and Nunez-Alonso,\n   Graciela A. and Monteiro, Octovia and Rogers, Catherine and Gamble,\n   Vicki and Burbano, Rommel and Brennan, Paul E. and Tallant, Cynthia and\n   Ebner, Daniel and Fedorov, Oleg and O'Neill, Eric and Knapp, Stefan and\n   Dixon, Darren and Muller, Susanne},\nTitle = {BET inhibition as a new strategy for the treatment of gastric cancer},\nJournal = {ONCOTARGET},\nYear = {2016},\nVolume = {7},\nNumber = {28},\nPages = {43997-44012},\nMonth = {JUL 12},\nDOI = {10.18632/oncotarget.9766},\nEISSN = {1949-2553},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Montenegro, Raquel/I-1260-2013\n   Fedorov, Oleg/B-6412-2014\n   Burbano, Rommel/C-4149-2012\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Montenegro, Raquel/0000-0002-3861-293X\n   Burbano, Rommel/0000-0002-4872-234X\n   Wan, Xiao/0000-0003-3600-7928\n   Ebner, Daniel/0000-0002-6495-7026\n   Tallant, Cynthia/0000-0001-5645-435X\n   Knapp, Stefan/0000-0001-5995-6494\n   Muller-Knapp, Susanne/0000-0003-2402-4157},\nUnique-ID = {WOS:000385395700084},\n}\n\n
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\n \n\n \n \n \n \n \n Structural analysis of human KDM5B guides histone demethylase inhibitor development.\n \n \n \n\n\n \n Johansson, C.; Velupillai, S.; Tumber, A.; Szykowska, A.; Hookway, E. S.; Nowak, R. P.; Strain-Damerell, C.; Gileadi, C.; Philpott, M.; Burgess-Brown, N.; Wu, N.; Kopec, J.; Nuzzi, A.; Steuber, H.; Egner, U.; Badock, V.; Munro, S.; LaThangue, N. B.; Westaway, S.; Brown, J.; Athanasou, N.; Prinjha, R.; Brennan, P. E.; and Oppermann, U.\n\n\n \n\n\n\n NATURE CHEMICAL BIOLOGY, 12(7): 539+. JUL 2016.\n \n\n\n\n
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@article{ WOS:000378087500014,\nAuthor = {Johansson, Catrine and Velupillai, Srikannathasan and Tumber, Anthony\n   and Szykowska, Aleksandra and Hookway, Edward S. and Nowak, Radoslaw P.\n   and Strain-Damerell, Claire and Gileadi, Carina and Philpott, Martin and\n   Burgess-Brown, Nicola and Wu, Na and Kopec, Jola and Nuzzi, Andrea and\n   Steuber, Holger and Egner, Ursula and Badock, Volker and Munro, Shonagh\n   and LaThangue, Nicholas B. and Westaway, Sue and Brown, Jack and\n   Athanasou, Nick and Prinjha, Rab and Brennan, Paul E. and Oppermann, Udo},\nTitle = {Structural analysis of human KDM5B guides histone demethylase inhibitor\n   development},\nJournal = {NATURE CHEMICAL BIOLOGY},\nYear = {2016},\nVolume = {12},\nNumber = {7},\nPages = {539+},\nMonth = {JUL},\nDOI = {10.1038/NCHEMBIO.2087},\nISSN = {1552-4450},\nEISSN = {1552-4469},\nResearcherID-Numbers = {Nowak, Radosław/JLM-2338-2023\n   Hookway, Edward/I-2613-2018\n   Brown, Tom/A-6655-2010\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Nowak, Radoslaw/0000-0002-0605-0071\n   Philpott, Martin/0000-0003-3632-0084},\nUnique-ID = {WOS:000378087500014},\n}\n\n
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\n \n\n \n \n \n \n \n Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.\n \n \n \n\n\n \n Mathea, S.; Azeez, K. R. A.; Salah, E.; Tallant, C.; Wolfreys, F.; Konietzny, R.; Fischer, R.; Lou, H. J.; Brennan, P. E.; Schnapp, G.; Pautsch, A.; Kessler, B. M.; Turk, B. E.; and Knapp, S.\n\n\n \n\n\n\n ACS CHEMICAL BIOLOGY, 11(6): 1595-1602. JUN 2016.\n \n\n\n\n
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@article{ WOS:000378302500015,\nAuthor = {Mathea, Sebastian and Azeez, Kamal R. Abdul and Salah, Eidarus and\n   Tallant, Cynthia and Wolfreys, Finn and Konietzny, Rebecca and Fischer,\n   Roman and Lou, Hua Jane and Brennan, Paul E. and Schnapp, Gisela and\n   Pautsch, Alexander and Kessler, Benedikt M. and Turk, Benjamin E. and\n   Knapp, Stefan},\nTitle = {Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib},\nJournal = {ACS CHEMICAL BIOLOGY},\nYear = {2016},\nVolume = {11},\nNumber = {6},\nPages = {1595-1602},\nMonth = {JUN},\nDOI = {10.1021/acschembio.6b00043},\nISSN = {1554-8929},\nEISSN = {1554-8937},\nResearcherID-Numbers = {Kessler, Benedikt/JGC-6978-2023\n   Knapp, Stefan/AAG-2347-2019\n   Fischer, Roman/N-4408-2017},\nORCID-Numbers = {Kessler, Benedikt/0000-0002-8160-2446\n   Mathea, Sebastian/0000-0001-8500-4569\n   Schnapp, Gisela/0000-0002-1529-0130\n   Knapp, Stefan/0000-0001-5995-6494\n   Tallant, Cynthia/0000-0001-5645-435X\n   Brennan, Paul/0000-0002-8950-7646\n   Fischer, Roman/0000-0002-9715-5951},\nUnique-ID = {WOS:000378302500015},\n}\n\n
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\n \n\n \n \n \n \n \n Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit.\n \n \n \n\n\n \n Gerstenberger, B. S.; Trzupek, J. D.; Tallant, C.; Fedorov, O.; Filippakopoulos, P.; Brennan, P. E.; Fedele, V.; Martin, S.; Picaud, S.; Rogers, C.; Parikh, M.; Taylor, A.; Samas, B.; O'Mahony, A.; Berg, E.; Pallares, G.; Torrey, A. D.; Treiber, D. K.; Samardjiev, I. J.; Nasipak, B. T.; Padilla-Benavides, T.; Wu, Q.; Imbalzano, A. N.; Nickerson, J. A.; Bunnage, M. E.; Muller, S.; Knapp, S.; and Owen, D. R.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 59(10): 4800-4811. MAY 26 2016.\n \n\n\n\n
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@article{ WOS:000376840600030,\nAuthor = {Gerstenberger, Brian S. and Trzupek, John D. and Tallant, Cynthia and\n   Fedorov, Oleg and Filippakopoulos, Panagis and Brennan, Paul E. and\n   Fedele, Vita and Martin, Sarah and Picaud, Sarah and Rogers, Catherine\n   and Parikh, Mihir and Taylor, Alexandria and Samas, Brian and O'Mahony,\n   Alison and Berg, Ellen and Pallares, Gabriel and Torrey, Adam D. and\n   Treiber, Daniel K. and Samardjiev, Ivan J. and Nasipak, Brian T. and\n   Padilla-Benavides, Teresita and Wu, Qiong and Imbalzano, Anthony N. and\n   Nickerson, Jeffrey A. and Bunnage, Mark E. and Muller, Susanne and\n   Knapp, Stefan and Owen, Dafydd R.},\nTitle = {Identification of a Chemical Probe for Family VIII Bromodomains through\n   Optimization of a Fragment Hit},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2016},\nVolume = {59},\nNumber = {10},\nPages = {4800-4811},\nMonth = {MAY 26},\nDOI = {10.1021/acs.jmedchem.6b00012},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Berg, Ellen/T-8827-2019\n   Fedorov, Oleg/B-6412-2014\n   Berg, Ellen/D-9076-2014\n   PADILLA-BENAVIDES, TERESITA/K-1968-2012\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Berg, Ellen/0000-0001-5149-6665\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Knapp, Stefan/0000-0001-5995-6494\n   Bunnage, Mark/0009-0002-6063-8041\n   PADILLA-BENAVIDES, TERESITA/0000-0002-4624-0822\n   Tallant, Cynthia/0000-0001-5645-435X\n   Muller-Knapp, Susanne/0000-0003-2402-4157},\nUnique-ID = {WOS:000376840600030},\n}\n\n
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\n \n\n \n \n \n \n \n Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.\n \n \n \n\n\n \n Sutherell, C. L.; Tallant, C.; Monteiro, O. P.; Yapp, C.; Fuchs, J. E.; Fedorov, O.; Siejka, P.; Muller, S.; Knapp, S.; Brenton, J. D.; Brennan, P. E.; and Ley, S. V.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 59(10): 5095-5101. MAY 26 2016.\n \n\n\n\n
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@article{ WOS:000376840600052,\nAuthor = {Sutherell, Charlotte L. and Tallant, Cynthia and Monteiro, Octovia P.\n   and Yapp, Clarence and Fuchs, Julian E. and Fedorov, Oleg and Siejka,\n   Paulina and Muller, Suzanne and Knapp, Stefan and Brenton, James D. and\n   Brennan, Paul E. and Ley, Steven V.},\nTitle = {Identification and Development of\n   2,3-Dihydropyrrolo{[}1,2-a]quinazolin-5(1H)-one Inhibitors\n   Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2016},\nVolume = {59},\nNumber = {10},\nPages = {5095-5101},\nMonth = {MAY 26},\nDOI = {10.1021/acs.jmedchem.5b01997},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Brenton, James/B-3174-2008\n   Fedorov, Oleg/B-6412-2014\n   Knapp, Stefan/AAG-2347-2019\n   Ley, Steven/O-7712-2016\n   },\nORCID-Numbers = {Tallant, Cynthia/0000-0001-5645-435X\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Knapp, Stefan/0000-0001-5995-6494\n   Ley, Steven/0000-0002-7816-0042\n   Brennan, Paul/0000-0002-8950-7646\n   Sutherell, Charlotte Louise/0000-0001-5987-4149},\nUnique-ID = {WOS:000376840600052},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.\n \n \n \n\n\n \n Bennett, J.; Fedorov, O.; Tallant, C.; Monteiro, O.; Meier, J.; Gamble, V.; Savitsky, P.; Nunez-Alonso, G. A.; Haendler, B.; Rogers, C.; Brennan, P. E.; Mueller, S.; and Knapp, S.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 59(4, SI): 1642-1647. FEB 25 2016.\n \n\n\n\n
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@article{ WOS:000371103600028,\nAuthor = {Bennett, James and Fedorov, Oleg and Tallant, Cynthia and Monteiro,\n   Octovia and Meier, Julia and Gamble, Vicky and Savitsky, Pavel and\n   Nunez-Alonso, Graciela A. and Haendler, Bernard and Rogers, Catherine\n   and Brennan, Paul E. and Mueller, Susanne and Knapp, Stefan},\nTitle = {Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of\n   TRIM24 and BRPF},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2016},\nVolume = {59},\nNumber = {4, SI},\nPages = {1642-1647},\nMonth = {FEB 25},\nDOI = {10.1021/acs.jmedchem.5b00458},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Fedorov, Oleg/B-6412-2014\n   Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {Tallant, Cynthia/0000-0001-5645-435X\n   Bennett, James/0000-0003-1396-8400\n   Savitsky, Pavel/0000-0001-8584-7750\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Knapp, Stefan/0000-0001-5995-6494\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000371103600028},\n}\n\n
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\n \n\n \n \n \n \n \n Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain.\n \n \n \n\n\n \n Chaikuad, A.; Lang, S.; Brennan, P. E.; Temperini, C.; Fedorov, O.; Hollander, J.; Nachane, R.; Abell, C.; Mueller, S.; Siegal, G.; and Knapp, S.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 59(4, SI): 1648-1653. FEB 25 2016.\n \n\n\n\n
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@article{ WOS:000371103600029,\nAuthor = {Chaikuad, Apirat and Lang, Steffen and Brennan, Paul E. and Temperini,\n   Claudia and Fedorov, Oleg and Hollander, Johan and Nachane, Ruta and\n   Abell, Chris and Mueller, Susanne and Siegal, Gregg and Knapp, Stefan},\nTitle = {Structure-Based Identification of Inhibitory Fragments Targeting the\n   p300/CBP-Associated Factor Bromodomain},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2016},\nVolume = {59},\nNumber = {4, SI},\nPages = {1648-1653},\nMonth = {FEB 25},\nDOI = {10.1021/acs.jmedchem.5b01719},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Chaikuad, Apirat/0000-0003-1120-2209\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Brennan, Paul/0000-0002-8950-7646\n   Knapp, Stefan/0000-0001-5995-6494\n   Siegal, Gregg/0000-0003-3806-4811},\nUnique-ID = {WOS:000371103600029},\n}\n\n
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\n \n\n \n \n \n \n \n Recent Progress in Histone Demethylase Inhibitors.\n \n \n \n\n\n \n McAllister, T. E.; England, K. S.; Hopkinson, R. J.; Brennan, P. E.; Kawamura, A.; and Schofield, C. J.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 59(4, SI): 1308-1329. FEB 25 2016.\n \n\n\n\n
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@article{ WOS:000371103600005,\nAuthor = {McAllister, Tom E. and England, Katherine S. and Hopkinson, Richard J.\n   and Brennan, Paul E. and Kawamura, Akane and Schofield, Christopher J.},\nTitle = {Recent Progress in Histone Demethylase Inhibitors},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2016},\nVolume = {59},\nNumber = {4, SI},\nPages = {1308-1329},\nMonth = {FEB 25},\nDOI = {10.1021/acs.jmedchem.5b01758},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Kawamura, Akane/I-4047-2018\n   Hopkinson, Richard/K-8372-2013\n   McAllister, Tom/AAU-6698-2020\n   },\nORCID-Numbers = {Kawamura, Akane/0000-0003-1169-5082\n   England, Katherine/0000-0002-4921-7505\n   Schofield, Chris/0009-0008-4988-0199\n   Schofield, Christopher/0000-0002-0290-6565\n   Hopkinson, Richard/0000-0001-7610-8163\n   McAllister, Tom/0000-0001-6906-4510\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000371103600005},\n}\n\n
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\n \n\n \n \n \n \n \n 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.\n \n \n \n\n\n \n Bavetsias, V.; Lanigan, R. M.; Ruda, G. F.; Atrash, B.; McLaughlin, M. G.; Tumber, A.; Mok, N. Y.; Le Bihan, Y.; Dempster, S.; Boxall, K. J.; Jeganathan, F.; Hatch, S. B.; Savitsky, P.; Velupillai, S.; Krojer, T.; England, K. S.; Sejberg, J.; Thai, C.; Donovan, A.; Pal, A.; Scozzafava, G.; Bennett, J. M.; Kawamura, A.; Johansson, C.; Szykowska, A.; Gileadi, C.; Burgess-Brown, N. A.; von Delft, F.; Oppermann, U.; Walters, Z.; Shipley, J.; Raynaud, F. I.; Westaway, S. M.; Prinjha, R. K.; Fedorov, O.; Burke, R.; Schofield, C. J.; Westwood, I. M.; Bountra, C.; Mueller, S.; van Montfort, R. L. M.; Brennan, P. E.; and Blagg, J.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 59(4, SI): 1388-1409. FEB 25 2016.\n \n\n\n\n
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@article{ WOS:000371103600011,\nAuthor = {Bavetsias, Vassilios and Lanigan, Rachel M. and Ruda, Gian Filippo and\n   Atrash, Butrus and McLaughlin, Mark G. and Tumber, Anthony and Mok, N.\n   Yi and Le Bihan, Yann-Vai and Dempster, Sally and Boxall, Katherine J.\n   and Jeganathan, Fiona and Hatch, Stephanie B. and Savitsky, Pavel and\n   Velupillai, Srikannathasan and Krojer, Tobias and England, Katherine S.\n   and Sejberg, Jimmy and Thai, Ching and Donovan, Adam and Pal, Akos and\n   Scozzafava, Giuseppe and Bennett, James M. and Kawamura, Akane and\n   Johansson, Catrine and Szykowska, Aleksandra and Gileadi, Carina and\n   Burgess-Brown, Nicola A. and von Delft, Frank and Oppermann, Udo and\n   Walters, Zoe and Shipley, Janet and Raynaud, Florence I. and Westaway,\n   Susan M. and Prinjha, Rab K. and Fedorov, Oleg and Burke, Rosemary and\n   Schofield, Christopher J. and Westwood, Isaac M. and Bountra, Chas and\n   Mueller, Susanne and van Montfort, Rob L. M. and Brennan, Paul E. and\n   Blagg, Julian},\nTitle = {8-Substituted Pyrido{[}3,4-d]pyrimidin-4(3H)-one\n   Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1)\n   Histone Lysine Demethylase Inhibitors},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2016},\nVolume = {59},\nNumber = {4, SI},\nPages = {1388-1409},\nMonth = {FEB 25},\nDOI = {10.1021/acs.jmedchem.5b01635},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Krojer, Tobias/ABE-3829-2021\n   Lanigan, Rachel/B-4830-2015\n   Fedorov, Oleg/B-6412-2014\n   McLaughlin, Mark/N-8192-2019\n   Knapp, Stefan/AAG-2347-2019\n   Kawamura, Akane/I-4047-2018\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Raynaud, Florence/0000-0003-0957-6279\n   Bennett, James/0000-0003-1396-8400\n   Hatch, Stephanie/0000-0002-7401-9279\n   England, Katherine/0000-0002-4921-7505\n   Le Bihan, Yann-Vai/0000-0002-6850-9706\n   McLaughlin, Mark/0000-0002-5999-4703\n   Walters, Zoe/0000-0002-1835-5868\n   Schofield, Christopher/0000-0002-0290-6565\n   Savitsky, Pavel/0000-0001-8584-7750\n   Kawamura, Akane/0000-0003-1169-5082\n   Ruda, Gian Filippo/0000-0001-6150-2715\n   von Delft, Frank/0000-0003-0378-0017\n   Shipley, Janet/0000-0001-6748-8678\n   Krojer, Tobias/0000-0003-0661-0814\n   Schofield, Chris/0009-0008-4988-0199},\nUnique-ID = {WOS:000371103600011},\n}\n\n
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\n \n\n \n \n \n \n \n Deciphering the true antiproliferative target of an MK2 activation inhibitor in glioblastoma.\n \n \n \n\n\n \n Brennan, P. E.\n\n\n \n\n\n\n CELL DEATH & DISEASE, 7. JAN 2016.\n \n\n\n\n
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@article{ WOS:000369181000027,\nAuthor = {Brennan, P. E.},\nTitle = {Deciphering the true antiproliferative target of an MK2 activation\n   inhibitor in glioblastoma},\nJournal = {CELL DEATH \\& DISEASE},\nYear = {2016},\nVolume = {7},\nMonth = {JAN},\nDOI = {10.1038/cddis.2015.384},\nArticle-Number = {e2069},\nISSN = {2041-4889},\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000369181000027},\n}\n\n
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\n \n\n \n \n \n \n \n A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain.\n \n \n \n\n\n \n Cox, O. B.; Krojer, T.; Collins, P.; Monteiro, O.; Talon, R.; Bradley, A.; Fedorov, O.; Amin, J.; Marsden, B. D.; Spencer, J.; von Delft, F.; and Brennan, P. E.\n\n\n \n\n\n\n CHEMICAL SCIENCE, 7(3): 2322-2330. 2016.\n \n\n\n\n
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@article{ WOS:000371021900087,\nAuthor = {Cox, Oakley B. and Krojer, Tobias and Collins, Patrick and Monteiro,\n   Octovia and Talon, Romain and Bradley, Anthony and Fedorov, Oleg and\n   Amin, Jahangir and Marsden, Brian D. and Spencer, John and von Delft,\n   Frank and Brennan, Paul E.},\nTitle = {A poised fragment library enables rapid synthetic expansion yielding the\n   first reported inhibitors of PHIP(2), an atypical bromodomain},\nJournal = {CHEMICAL SCIENCE},\nYear = {2016},\nVolume = {7},\nNumber = {3},\nPages = {2322-2330},\nDOI = {10.1039/c5sc03115j},\nISSN = {2041-6520},\nEISSN = {2041-6539},\nResearcherID-Numbers = {SPENCER, John/P-5492-2019\n   Krojer, Tobias/ABE-3829-2021\n   Collins, Patrick/C-7960-2016\n   Spencer, John/C-2156-2008\n   },\nORCID-Numbers = {Talon, Romain/0000-0003-1123-7241\n   Brennan, Paul/0000-0002-8950-7646\n   Collins, Patrick/0000-0002-6265-9922\n   von Delft, Frank/0000-0003-0378-0017\n   Spencer, John/0000-0001-5231-8836\n   Krojer, Tobias/0000-0003-0661-0814},\nUnique-ID = {WOS:000371021900087},\n}\n\n
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\n \n\n \n \n \n \n \n Chemical probes and inhibitors of bromodomains outside the BET family.\n \n \n \n\n\n \n Moustakim, M.; Clark, P. G. K.; Hay, D. A.; Dixon, D. J.; and Brennan, P. E.\n\n\n \n\n\n\n MEDCHEMCOMM, 7(12): 2246-2264. 2016.\n \n\n\n\n
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@article{ WOS:000390552300004,\nAuthor = {Moustakim, Moses and Clark, Peter G. K. and Hay, Duncan A. and Dixon,\n   Darren J. and Brennan, Paul E.},\nTitle = {Chemical probes and inhibitors of bromodomains outside the BET family},\nJournal = {MEDCHEMCOMM},\nYear = {2016},\nVolume = {7},\nNumber = {12},\nPages = {2246-2264},\nDOI = {10.1039/c6md00373g},\nISSN = {2040-2503},\nEISSN = {2040-2511},\nResearcherID-Numbers = {Moustakim, Moses/LKM-9655-2024\n   },\nORCID-Numbers = {Moustakim, Moses/0000-0002-5006-5684},\nUnique-ID = {WOS:000390552300004},\n}\n\n
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\n  \n 2015\n \n \n (9)\n \n \n
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\n \n\n \n \n \n \n \n Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.\n \n \n \n\n\n \n Picaud, S.; Fedorov, O.; Thanasopoulou, A.; Leonards, K.; Jones, K.; Meier, J.; Olzscha, H.; Monteiro, O.; Martin, S.; Philpott, M.; Tumber, A.; Filippakopoulos, P.; Yapp, C.; Wells, C.; Che, K. H.; Bannister, A.; Robson, S.; Kumar, U.; Parr, N.; Lee, K.; Lugo, D.; Jeffrey, P.; Taylor, S.; Vecellio, M. L.; Bountra, C.; Brennan, P. E.; O'Mahony, A.; Velichko, S.; Mueller, S.; Hay, D.; Daniels, D. L.; Urh, M.; La Thangue, N. B.; Kouzarides, T.; Prinjha, R.; Schwaller, J.; and Knapp, S.\n\n\n \n\n\n\n CANCER RESEARCH, 75(23): 5106-5119. DEC 1 2015.\n \n\n\n\n
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@article{ WOS:000365603000011,\nAuthor = {Picaud, Sarah and Fedorov, Oleg and Thanasopoulou, Angeliki and\n   Leonards, Katharina and Jones, Katherine and Meier, Julia and Olzscha,\n   Heidi and Monteiro, Octovia and Martin, Sarah and Philpott, Martin and\n   Tumber, Anthony and Filippakopoulos, Panagis and Yapp, Clarence and\n   Wells, Christopher and Che, Ka Hing and Bannister, Andrew and Robson,\n   Samuel and Kumar, Umesh and Parr, Nigel and Lee, Kevin and Lugo, Dave\n   and Jeffrey, Philip and Taylor, Simon and Vecellio, Matteo L. and\n   Bountra, Chas and Brennan, Paul E. and O'Mahony, Alison and Velichko,\n   Sharlene and Mueller, Susanne and Hay, Duncan and Daniels, Danette L.\n   and Urh, Marjeta and La Thangue, Nicholas B. and Kouzarides, Tony and\n   Prinjha, Rab and Schwaller, Juerg and Knapp, Stefan},\nTitle = {Generation of a Selective Small Molecule Inhibitor of the CBP/p300\n   Bromodomain for Leukemia Therapy},\nJournal = {CANCER RESEARCH},\nYear = {2015},\nVolume = {75},\nNumber = {23},\nPages = {5106-5119},\nMonth = {DEC 1},\nDOI = {10.1158/0008-5472.CAN-15-0236},\nISSN = {0008-5472},\nEISSN = {1538-7445},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Olzscha, Heidi/AAU-1296-2020\n   Vecellio, Matteo Luca/HGB-6768-2022\n   Schwaller, Juerg/A-3044-2016\n   Fedorov, Oleg/B-6412-2014\n   Brown, Tom/A-6655-2010\n   },\nORCID-Numbers = {Knapp, Stefan/0000-0001-5995-6494\n   Philpott, Martin/0000-0003-3632-0084\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Brennan, Paul/0000-0002-8950-7646\n   Robson, Samuel Charles/0000-0001-5702-9160\n   Vecellio, Matteo Luca/0000-0002-8643-1316\n   Bannister, Andrew/0000-0002-6312-4436\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Kouzarides, Tony/0000-0002-8918-4162\n   Olzscha, Heidi/0000-0002-1929-1384},\nUnique-ID = {WOS:000365603000011},\n}\n\n
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\n \n\n \n \n \n \n \n Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.\n \n \n \n\n\n \n Fedorov, O.; Castex, J.; Tallant, C.; Owen, D. R.; Martin, S.; Aldeghi, M.; Monteiro, O.; Filippakopoulos, P.; Picaud, S.; Trzupek, J. D.; Gerstenberger, B. S.; Bountra, C.; Willmann, D.; Wells, C.; Philpott, M.; Rogers, C.; Biggin, P. C.; Brennan, P. E.; Bunnage, M. E.; Schuele, R.; Guenther, T.; Knapp, S.; and Mueller, S.\n\n\n \n\n\n\n SCIENCE ADVANCES, 1(10). NOV 2015.\n \n\n\n\n
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@article{ WOS:000216599300015,\nAuthor = {Fedorov, Oleg and Castex, Josefina and Tallant, Cynthia and Owen, Dafydd\n   R. and Martin, Sarah and Aldeghi, Matteo and Monteiro, Octovia and\n   Filippakopoulos, Panagis and Picaud, Sarah and Trzupek, John D. and\n   Gerstenberger, Brian S. and Bountra, Chas and Willmann, Dominica and\n   Wells, Christopher and Philpott, Martin and Rogers, Catherine and\n   Biggin, Philip C. and Brennan, Paul E. and Bunnage, Mark E. and Schuele,\n   Roland and Guenther, Thomas and Knapp, Stefan and Mueller, Susanne},\nTitle = {Selective targeting of the BRG/PB1 bromodomains impairs embryonic and\n   trophoblast stem cell maintenance},\nJournal = {SCIENCE ADVANCES},\nYear = {2015},\nVolume = {1},\nNumber = {10},\nMonth = {NOV},\nDOI = {10.1126/sciadv.1500723},\nArticle-Number = {e1500723},\nISSN = {2375-2548},\nResearcherID-Numbers = {Schüle, Rebecca/B-5763-2019\n   Knapp, Stefan/AAG-2347-2019\n   Brown, Tom/A-6655-2010\n   },\nORCID-Numbers = {Bunnage, Mark/0009-0002-6063-8041\n   Gunther, Thomas/0000-0003-3903-9490\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Aldeghi, Matteo/0000-0003-0019-8806\n   Philpott, Martin/0000-0003-3632-0084\n   Knapp, Stefan/0000-0001-5995-6494\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Biggin, Philip/0000-0001-5100-8836\n   Fedorov, Oleg/0000-0002-8662-7300\n   Tallant, Cynthia/0000-0001-5645-435X\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000216599300015},\n}\n\n
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\n \n\n \n \n \n \n \n Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.\n \n \n \n\n\n \n Canning, P.; Ruan, Q.; Schwerd, T.; Hrdinka, M.; Maki, J. L.; Saleh, D.; Suebsuwong, C.; Ray, S.; Brennan, P. E.; Cuny, G. D.; Uhlig, H. H.; Gyrd-Hansen, M.; Degterev, A.; and Bullock, A. N.\n\n\n \n\n\n\n CHEMISTRY & BIOLOGY, 22(9): 1174-1184. SEP 17 2015.\n \n\n\n\n
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@article{ WOS:000364012100003,\nAuthor = {Canning, Peter and Ruan, Qui and Schwerd, Tobias and Hrdinka, Matous and\n   Maki, Jenny L. and Saleh, Danish and Suebsuwong, Chalada and Ray, Soumya\n   and Brennan, Paul E. and Cuny, Gregory D. and Uhlig, Holm H. and\n   Gyrd-Hansen, Mads and Degterev, Alexei and Bullock, Alex N.},\nTitle = {Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant\n   Type II Kinase Inhibitors},\nJournal = {CHEMISTRY \\& BIOLOGY},\nYear = {2015},\nVolume = {22},\nNumber = {9},\nPages = {1174-1184},\nMonth = {SEP 17},\nDOI = {10.1016/j.chembiol.2015.07.017},\nISSN = {1074-5521},\nEISSN = {1879-1301},\nResearcherID-Numbers = {Hrdinka, Matous/B-9187-2011\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Suebsuwong, Chalada/0000-0001-9406-0386\n   Canning, Peter/0000-0001-9678-4169\n   Uhlig, Holm/0000-0002-6111-7355\n   Gyrd-Hansen, Mads/0000-0001-5641-5019\n   Cuny, Gregory/0000-0002-3188-4748\n   Hrdinka, Matous/0000-0002-2981-2825},\nUnique-ID = {WOS:000364012100003},\n}\n\n
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\n \n\n \n \n \n \n \n CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.\n \n \n \n\n\n \n Hammitzsch, A.; Tallant, C.; Fedorov, O.; O'Mahony, A.; Brennan, P. E.; Hay, D. A.; Martinez, F. O.; Al-Mossawi, M. H.; de Wit, J.; Vecellio, M.; Wells, C.; Wordsworth, P.; Mueller, S.; Knapp, S.; and Bowness, P.\n\n\n \n\n\n\n PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(34): 10768-10773. AUG 25 2015.\n \n\n\n\n
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@article{ WOS:000360005600065,\nAuthor = {Hammitzsch, Ariane and Tallant, Cynthia and Fedorov, Oleg and O'Mahony,\n   Alison and Brennan, Paul E. and Hay, Duncan A. and Martinez, Fernando O.\n   and Al-Mossawi, M. Hussein and de Wit, Jelle and Vecellio, Matteo and\n   Wells, Christopher and Wordsworth, Paul and Mueller, Susanne and Knapp,\n   Stefan and Bowness, Paul},\nTitle = {CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17\n   responses},\nJournal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF\n   AMERICA},\nYear = {2015},\nVolume = {112},\nNumber = {34},\nPages = {10768-10773},\nMonth = {AUG 25},\nDOI = {10.1073/pnas.1501956112},\nISSN = {0027-8424},\nResearcherID-Numbers = {Bowness, Paul/AAH-2484-2019\n   Knapp, Stefan/AAG-2347-2019\n   Hammitzsch, Ariane/M-6890-2019\n   Fedorov, Oleg/B-6412-2014\n   Vecellio, Matteo Luca/HGB-6768-2022\n   Martinez Estrada, Fernando O/AAW-9409-2021\n   de Wit, Jelle/W-7035-2019\n   Al-Mossawi, Hussein/I-5903-2015\n   },\nORCID-Numbers = {de Wit, Jelle/0000-0003-2444-6050\n   Martinez Estrada, Fernando O/0000-0003-0908-9366\n   bowness, paul/0000-0003-4597-0484\n   Hammitzsch, Ariane/0000-0003-2658-4764\n   Tallant, Cynthia/0000-0001-5645-435X\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Vecellio, Matteo Luca/0000-0002-8643-1316\n   Brennan, Paul/0000-0002-8950-7646\n   Al-Mossawi, Hussein/0000-0002-2312-3754\n   Knapp, Stefan/0000-0001-5995-6494},\nUnique-ID = {WOS:000360005600065},\n}\n\n
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\n \n\n \n \n \n \n \n The promise and peril of chemical probes.\n \n \n \n\n\n \n Arrowsmith, C. H.; Audia, J. E.; Austin, C.; Baell, J.; Bennett, J.; Blagg, J.; Bountra, C.; Brennan, P. E.; Brown, P. J.; Bunnage, M. E.; Buser-Doepner, C.; Campbell, R. M.; Carter, A. J.; Cohen, P.; Copeland, R. A.; Cravatt, B.; Dahlin, J. L.; Dhanak, D.; Edwards, A. M.; Frye, S. V.; Gray, N.; Grimshaw, C. E.; Hepworth, D.; Howe, T.; Huber, K. V. M.; Jin, J.; Knapp, S.; Kotz, J. D.; Kruger, R. G.; Lowe, D.; Mader, M. M.; Marsden, B.; Mueller-Fahrnow, A.; Mueller, S.; O'Hagan, R. C.; Overington, J. P.; Owen, D. R.; Rosenberg, S. H.; Roth, B.; Ross, R.; Schapira, M.; Schreiber, S. L.; Shoichet, B.; Sundstrom, M.; Superti-Furga, G.; Taunton, J.; Toledo-Sherman, L.; Walpole, C.; Walters, M. A.; Willson, T. M.; Workman, P.; Young, R. N.; and Zuercher, W. J.\n\n\n \n\n\n\n NATURE CHEMICAL BIOLOGY, 11(8): 536-541. AUG 2015.\n \n\n\n\n
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@article{ WOS:000358255300003,\nAuthor = {Arrowsmith, Cheryl H. and Audia, James E. and Austin, Christopher and\n   Baell, Jonathan and Bennett, Jonathan and Blagg, Julian and Bountra,\n   Chas and Brennan, Paul E. and Brown, Peter J. and Bunnage, Mark E. and\n   Buser-Doepner, Carolyn and Campbell, Robert M. and Carter, Adrian J. and\n   Cohen, Philip and Copeland, Robert A. and Cravatt, Ben and Dahlin, Jayme\n   L. and Dhanak, Dashyant and Edwards, Aled M. and Frye, Stephen V. and\n   Gray, Nathanael and Grimshaw, Charles E. and Hepworth, David and Howe,\n   Trevor and Huber, Kilian V. M. and Jin, Jian and Knapp, Stefan and Kotz,\n   Joanne D. and Kruger, Ryan G. and Lowe, Derek and Mader, Mary M. and\n   Marsden, Brian and Mueller-Fahrnow, Anke and Mueller, Susanne and\n   O'Hagan, Ronan C. and Overington, John P. and Owen, Dafydd R. and\n   Rosenberg, Saul H. and Roth, Brian and Ross, Ruth and Schapira, Matthieu\n   and Schreiber, Stuart L. and Shoichet, Brian and Sundstrom, Michael and\n   Superti-Furga, Giulio and Taunton, Jack and Toledo-Sherman, Leticia and\n   Walpole, Chris and Walters, Michael A. and Willson, Timothy M. and\n   Workman, Paul and Young, Robert N. and Zuercher, William J.},\nTitle = {The promise and peril of chemical probes},\nJournal = {NATURE CHEMICAL BIOLOGY},\nYear = {2015},\nVolume = {11},\nNumber = {8},\nPages = {536-541},\nMonth = {AUG},\nDOI = {10.1038/nchembio.1867},\nISSN = {1552-4450},\nEISSN = {1552-4469},\nResearcherID-Numbers = {Walters, Michael/AFL-5751-2022\n   feinstein, doug/M-9414-2019\n   Superti-Furga, Giulio/AAE-5681-2019\n   Copeland, Robert/KTI-3412-2024\n   Dahlin, Jayme/AAM-2306-2021\n   Knapp, Stefan/AAG-2347-2019\n   Shoichet, Brian/AEJ-0474-2022\n   Baell, Jonathan/E-5844-2017\n   Schreiber, Stuart L./HGD-6678-2022\n   Cohen, Pascale/I-5875-2012\n   Huber, Kilian/L-6921-2015\n   Overington, John/G-8607-2015},\nORCID-Numbers = {Arrowsmith, Cheryl/0000-0002-4971-3250\n   Copeland, Robert/0000-0002-1897-6533\n   Dahlin, Jayme/0000-0003-4151-9944\n   Willson, Timothy/0000-0003-4181-8223\n   Huber, Kilian/0000-0002-1103-5300\n   Baell, Jonathan/0000-0003-2114-8242\n   Bunnage, Mark/0009-0002-6063-8041\n   Carter, Adrian/0000-0001-6564-7161\n   Knapp, Stefan/0000-0001-5995-6494\n   Young, Robert/0000-0002-8235-6080\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Edwards, Aled/0000-0002-4782-6016\n   Brown, Peter J/0000-0002-8454-0367\n   Cohen, Philip/0000-0001-7632-9492\n   Walters, Michael/0000-0001-5650-9277\n   Brennan, Paul/0000-0002-8950-7646\n   Overington, John/0000-0002-5859-1064},\nUnique-ID = {WOS:000358255300003},\n}\n\n
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\n \n\n \n \n \n \n \n LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor.\n \n \n \n\n\n \n Clark, P. G. K.; Vieira, L. C. C.; Tallant, C.; Fedorov, O.; Singleton, D. C.; Rogers, C. M.; Monteiro, O. P.; Bennett, J. M.; Baronio, R.; Mueller, S.; Daniels, D. L.; Mendez, J.; Knapp, S.; Brennan, P. E.; and Dixon, D. J.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(21): 6217-6221. MAY 18 2015.\n \n\n\n\n
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@article{ WOS:000354260000017,\nAuthor = {Clark, Peter G. K. and Vieira, Lucas C. C. and Tallant, Cynthia and\n   Fedorov, Oleg and Singleton, Dean C. and Rogers, Catherine M. and\n   Monteiro, Octovia P. and Bennett, James M. and Baronio, Roberta and\n   Mueller, Susanne and Daniels, Danette L. and Mendez, Jacqui and Knapp,\n   Stefan and Brennan, Paul E. and Dixon, Darren J.},\nTitle = {LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain\n   Inhibitor},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2015},\nVolume = {54},\nNumber = {21},\nPages = {6217-6221},\nMonth = {MAY 18},\nDOI = {10.1002/anie.201501394},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Singleton, Dean/HJY-8924-2023\n   Campos Curcino Vieira, Lucas/V-2535-2019\n   },\nORCID-Numbers = {Knapp, Stefan/0000-0001-5995-6494\n   Brennan, Paul/0000-0002-8950-7646\n   Bennett, James/0000-0003-1396-8400\n   Singleton, Dean/0000-0002-2044-8078\n   Campos Curcino Vieira, Lucas/0000-0002-1138-9117\n   Tallant, Cynthia/0000-0001-5645-435X\n   Muller-Knapp, Susanne/0000-0003-2402-4157},\nUnique-ID = {WOS:000354260000017},\n}\n\n
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\n \n\n \n \n \n \n \n K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.\n \n \n \n\n\n \n Dong, Y. Y.; Pike, A. C. W.; Mackenzie, A.; McClenaghan, C.; Aryal, P.; Dong, L.; Quigley, A.; Grieben, M.; Goubin, S.; Mukhopadhyay, S.; Ruda, G. F.; Clausen, M. V.; Cao, L.; Brennan, P. E.; Burgess-Brown, N. A.; Sansom, M. S. P.; Tucker, S. J.; and Carpenter, E. P.\n\n\n \n\n\n\n SCIENCE, 347(6227): 1256-1259. MAR 13 2015.\n \n\n\n\n
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@article{ WOS:000350824300040,\nAuthor = {Dong, Yin Yao and Pike, Ashley C. W. and Mackenzie, Alexandra and\n   McClenaghan, Conor and Aryal, Prafulla and Dong, Liang and Quigley,\n   Andrew and Grieben, Mariana and Goubin, Solenne and Mukhopadhyay,\n   Shubhashish and Ruda, Gian Filippo and Clausen, Michael V. and Cao,\n   Lishuang and Brennan, Paul E. and Burgess-Brown, Nicola A. and Sansom,\n   Mark S. P. and Tucker, Stephen J. and Carpenter, Elisabeth P.},\nTitle = {K2P channel gating mechanisms revealed by structures of TREK-2 and a\n   complex with Prozac},\nJournal = {SCIENCE},\nYear = {2015},\nVolume = {347},\nNumber = {6227},\nPages = {1256-1259},\nMonth = {MAR 13},\nDOI = {10.1126/science.1261512},\nISSN = {0036-8075},\nEISSN = {1095-9203},\nResearcherID-Numbers = {Tucker, Stephen/ABE-7468-2020\n   Sansom, Mark/C-5157-2009\n   Dong, Liang/IAR-4638-2023\n   },\nORCID-Numbers = {Quigley, Andrew/0000-0002-5022-9845\n   Mukhopadhyay, Shubhashish M M/0000-0003-1430-5529\n   Carpenter, Liz/0000-0001-9138-2937\n   Voldsgaard Clausen, Michael/0000-0002-7176-5524\n   Pike, Ashley/0000-0001-9661-2607\n   Dong, Yin/0000-0001-8600-6988\n   McClenaghan, Conor/0000-0002-0859-3854\n   Ruda, Gian Filippo/0000-0001-6150-2715\n   Brennan, Paul/0000-0002-8950-7646\n   Tucker, Stephen/0000-0001-8996-2000},\nUnique-ID = {WOS:000350824300040},\n}\n\n
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\n \n\n \n \n \n \n \n Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.\n \n \n \n\n\n \n Thinnes, C. C.; Tumber, A.; Yapp, C.; Scozzafava, G.; Yeh, T.; Chan, M. C.; Tran, T. A.; Hsu, K.; Tarhonskaya, H.; Walport, L. J.; Wilkins, S. E.; Martinez, E. D.; Mueller, S.; Pugh, C. W.; Ratcliffe, P. J.; Brennan, P. E.; Kawamura, A.; and Schofield, C. J.\n\n\n \n\n\n\n CHEMICAL COMMUNICATIONS, 51(84): 15458-15461. 2015.\n \n\n\n\n
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@article{ WOS:000363167600026,\nAuthor = {Thinnes, C. C. and Tumber, A. and Yapp, C. and Scozzafava, G. and Yeh,\n   T. and Chan, M. C. and Tran, T. A. and Hsu, K. and Tarhonskaya, H. and\n   Walport, L. J. and Wilkins, S. E. and Martinez, E. D. and Mueller, S.\n   and Pugh, C. W. and Ratcliffe, P. J. and Brennan, P. E. and Kawamura, A.\n   and Schofield, C. J.},\nTitle = {Betti reaction enables efficient synthesis of 8-hydroxyquinoline\n   inhibitors of 2-oxoglutarate oxygenases},\nJournal = {CHEMICAL COMMUNICATIONS},\nYear = {2015},\nVolume = {51},\nNumber = {84},\nPages = {15458-15461},\nDOI = {10.1039/c5cc06095h},\nISSN = {1359-7345},\nEISSN = {1364-548X},\nResearcherID-Numbers = {Walport, Louise/ABB-3578-2020\n   Chan, Mun/T-4867-2019\n   Kawamura, Akane/I-4047-2018},\nORCID-Numbers = {Hsu, Kuo-Feng/0000-0001-9556-9221\n   Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Wilkins, Sarah/0000-0003-1347-3328\n   Schofield, Chris/0009-0008-4988-0199\n   Ratcliffe, Peter/0000-0002-2853-806X\n   Pugh, Chris/0000-0002-5170-1662\n   Schofield, Christopher/0000-0002-0290-6565\n   Chan, Mun Chiang/0000-0002-3162-6036\n   Walport, Louise/0000-0002-3795-8365\n   Kawamura, Akane/0000-0003-1169-5082},\nUnique-ID = {WOS:000363167600026},\n}\n\n
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\n \n\n \n \n \n \n \n Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains.\n \n \n \n\n\n \n Hay, D. A.; Rogers, C. M.; Fedorov, O.; Tallant, C.; Martin, S.; Monteiro, O. P.; Mueller, S.; Knapp, S.; Schofield, C. J.; and Brennan, P. E.\n\n\n \n\n\n\n MEDCHEMCOMM, 6(7): 1381-1386. 2015.\n \n\n\n\n
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@article{ WOS:000357786200021,\nAuthor = {Hay, Duncan A. and Rogers, Catherine M. and Fedorov, Oleg and Tallant,\n   Cynthia and Martin, Sarah and Monteiro, Octovia P. and Mueller, Susanne\n   and Knapp, Stefan and Schofield, Christopher J. and Brennan, Paul E.},\nTitle = {Design and synthesis of potent and selective inhibitors of BRD7 and BRD9\n   bromodomains},\nJournal = {MEDCHEMCOMM},\nYear = {2015},\nVolume = {6},\nNumber = {7},\nPages = {1381-1386},\nDOI = {10.1039/c5md00152h},\nISSN = {2040-2503},\nEISSN = {2040-2511},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Tallant, Cynthia/0000-0001-5645-435X\n   Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Schofield, Chris/0009-0008-4988-0199},\nUnique-ID = {WOS:000357786200021},\n}\n\n
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\n  \n 2014\n \n \n (7)\n \n \n
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\n \n\n \n \n \n \n \n Optimizing in vivo probes for the BET bromodomains.\n \n \n \n\n\n \n Jennings, L. E.; Hewings, D. S.; Humphreys, P. G.; Brennan, P. E.; and Conway, S. J.\n\n\n \n\n\n\n ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 248. AUG 10 2014.\n 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA, AUG 10-14, 2014\n\n\n\n
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@article{ WOS:000349167402158,\nAuthor = {Jennings, Laura E. and Hewings, David S. and Humphreys, Philip G. and\n   Brennan, Paul E. and Conway, Stuart J.},\nTitle = {Optimizing in vivo probes for the BET bromodomains},\nJournal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2014},\nVolume = {248},\nMeeting = {353-MEDI},\nMonth = {AUG 10},\nNote = {248th National Meeting of the American-Chemical-Society (ACS), San\n   Francisco, CA, AUG 10-14, 2014},\nOrganization = {Amer Chem Soc},\nISSN = {0065-7727},\nResearcherID-Numbers = {Conway, Stuart/AAP-3526-2020\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000349167402158},\n}\n\n
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\n \n\n \n \n \n \n \n Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains.\n \n \n \n\n\n \n Hay, D. A.; Fedorov, O.; Martin, S.; Singleton, D. C.; Tallant, C.; Wells, C.; Picaud, S.; Philpott, M.; Monteiro, O. P.; Rogers, C. M.; Conway, S. J.; Rooney, T. P. C.; Tumber, A.; Yapp, C.; Filippakopoulos, P.; Bunnage, M. E.; Mueller, S.; Knapp, S.; Schofield, C. J.; and Brennan, P. E.\n\n\n \n\n\n\n JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(26): 9308-9319. JUL 2 2014.\n \n\n\n\n
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@article{ WOS:000338692700017,\nAuthor = {Hay, Duncan A. and Fedorov, Oleg and Martin, Sarah and Singleton, Dean\n   C. and Tallant, Cynthia and Wells, Christopher and Picaud, Sarah and\n   Philpott, Martin and Monteiro, Octovia P. and Rogers, Catherine M. and\n   Conway, Stuart J. and Rooney, Timothy P. C. and Tumber, Anthony and\n   Yapp, Clarence and Filippakopoulos, Panagis and Bunnage, Mark E. and\n   Mueller, Susanne and Knapp, Stefan and Schofield, Christopher J. and\n   Brennan, Paul E.},\nTitle = {Discovery and Optimization of Small-Molecule Ligands for the CBP/p300\n   Bromodomains},\nJournal = {JOURNAL OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2014},\nVolume = {136},\nNumber = {26},\nPages = {9308-9319},\nMonth = {JUL 2},\nDOI = {10.1021/ja412434f},\nISSN = {0002-7863},\nEISSN = {1520-5126},\nResearcherID-Numbers = {Brown, Tom/A-6655-2010\n   Singleton, Dean/HJY-8924-2023\n   Knapp, Stefan/AAG-2347-2019\n   Conway, Stuart/AAP-3526-2020\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Singleton, Dean/0000-0002-2044-8078\n   Schofield, Chris/0009-0008-4988-0199\n   Rooney, Timothy/0000-0001-6788-5526\n   Conway, Stuart/0000-0002-5148-117X\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Knapp, Stefan/0000-0001-5995-6494\n   Schofield, Christopher/0000-0002-0290-6565\n   Tallant, Cynthia/0000-0001-5645-435X\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Wells-Holland, Chris/0000-0001-9985-9816\n   Philpott, Martin/0000-0003-3632-0084\n   Bunnage, Mark/0009-0002-6063-8041},\nUnique-ID = {WOS:000338692700017},\n}\n\n
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\n \n\n \n \n \n \n \n A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction.\n \n \n \n\n\n \n Rooney, T. P. C.; Filippakopoulos, P.; Fedorov, O.; Picaud, S.; Cortopassi, W. A.; Hay, D. A.; Martin, S.; Tumber, A.; Rogers, C. M.; Philpott, M.; Wang, M.; Thompson, A. L.; Heightman, T. D.; Pryde, D. C.; Cook, A.; Paton, R. S.; Mueller, S.; Knapp, S.; Brennan, P. E.; and Conway, S. J.\n\n\n \n\n\n\n ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(24): 6126-6130. JUN 2014.\n \n\n\n\n
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@article{ WOS:000337095000015,\nAuthor = {Rooney, Timothy P. C. and Filippakopoulos, Panagis and Fedorov, Oleg and\n   Picaud, Sarah and Cortopassi, Wilian A. and Hay, Duncan A. and Martin,\n   Sarah and Tumber, Anthony and Rogers, Catherine M. and Philpott, Martin\n   and Wang, Minghua and Thompson, Amber L. and Heightman, Tom D. and\n   Pryde, David C. and Cook, Andrew and Paton, Robert S. and Mueller,\n   Susanne and Knapp, Stefan and Brennan, Paul E. and Conway, Stuart J.},\nTitle = {A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit\n   Pocket Stabilized by a Cation-π Interaction},\nJournal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION},\nYear = {2014},\nVolume = {53},\nNumber = {24},\nPages = {6126-6130},\nMonth = {JUN},\nDOI = {10.1002/anie.201402750},\nISSN = {1433-7851},\nEISSN = {1521-3773},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Conway, Stuart/AAP-3526-2020\n   Cook, Andrew/A-8652-2015\n   Paton, Robert/A-4564-2010\n   Brown, Tom/A-6655-2010\n   Cortopassi, Wilian/P-3136-2014\n   },\nORCID-Numbers = {Filippakopoulos, Panagis/0000-0002-1515-1317\n   Rooney, Timothy/0000-0001-6788-5526\n   Conway, Stuart/0000-0002-5148-117X\n   Philpott, Martin/0000-0003-3632-0084\n   Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Cortopassi, Wilian/0000-0001-8038-7847\n   Knapp, Stefan/0000-0001-5995-6494\n   Paton, Robert/0000-0002-0104-4166},\nUnique-ID = {WOS:000337095000015},\n}\n\n
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\n \n\n \n \n \n \n \n Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography.\n \n \n \n\n\n \n Guetzoyan, L.; Ingham, R. J.; Nikbin, N.; Rossignol, J.; Wolling, M.; Baumert, M.; Burgess-Brown, N. A.; Strain-Damerell, C. M.; Shrestha, L.; Brennan, P. E.; Fedorov, O.; Knapp, S.; and Ley, S. V.\n\n\n \n\n\n\n MEDCHEMCOMM, 5(4): 540-546. APR 2014.\n \n\n\n\n
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@article{ WOS:000333580000019,\nAuthor = {Guetzoyan, Lucie and Ingham, Richard J. and Nikbin, Nikzad and\n   Rossignol, Julien and Wolling, Michael and Baumert, Mark and\n   Burgess-Brown, Nicola A. and Strain-Damerell, Claire M. and Shrestha,\n   Leela and Brennan, Paul E. and Fedorov, Oleg and Knapp, Stefan and Ley,\n   Steven V.},\nTitle = {Machine-assisted synthesis of modulators of the histone reader BRD9\n   using flow methods of chemistry and frontal affinity chromatography},\nJournal = {MEDCHEMCOMM},\nYear = {2014},\nVolume = {5},\nNumber = {4},\nPages = {540-546},\nMonth = {APR},\nDOI = {10.1039/c4md00007b},\nISSN = {2040-2503},\nEISSN = {2040-2511},\nResearcherID-Numbers = {Fedorov, Oleg/B-6412-2014\n   Rossignol, Julien/MYS-5360-2025\n   Knapp, Stefan/AAG-2347-2019\n   Ley, Steven/O-7712-2016\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646\n   Ley, Steven/0000-0002-7816-0042\n   Ingham, Richard/0000-0003-2463-3323},\nUnique-ID = {WOS:000333580000019},\n}\n\n
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\n \n\n \n \n \n \n \n [1,2,4]Triazolo[4,3-a]phthalazines: Inhibitors of Diverse Bromodomains.\n \n \n \n\n\n \n Fedorov, O.; Lingard, H.; Wells, C.; Monteiro, O. P.; Picaud, S.; Keates, T.; Yapp, C.; Philpott, M.; Martin, S. J.; Felletar, I.; Marsden, B. D.; Filippakopoulos, P.; Mueller, S.; Knapp, S.; and Brennan, P. E.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 57(2): 462-476. JAN 23 2014.\n \n\n\n\n
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@article{ WOS:000330252500016,\nAuthor = {Fedorov, Oleg and Lingard, Hannah and Wells, Chris and Monteiro, Octovia\n   P. and Picaud, Sarah and Keates, Tracy and Yapp, Clarence and Philpott,\n   Martin and Martin, Sarah J. and Felletar, Ildiko and Marsden, Brian D.\n   and Filippakopoulos, Panagis and Mueller, Susanne and Knapp, Stefan and\n   Brennan, Paul E.},\nTitle = {{[}1,2,4]Triazolo{[}4,3-a]phthalazines: Inhibitors of Diverse\n   Bromodomains},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2014},\nVolume = {57},\nNumber = {2},\nPages = {462-476},\nMonth = {JAN 23},\nDOI = {10.1021/jm401568s},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Martin, Seamus/F-6701-2013\n   Brown, Tom/A-6655-2010\n   Fedorov, Oleg/B-6412-2014\n   Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {Muller-Knapp, Susanne/0000-0003-2402-4157\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Knapp, Stefan/0000-0001-5995-6494\n   Lingard, Hannah/0000-0003-2571-2496\n   Philpott, Martin/0000-0003-3632-0084\n   Wells-Holland, Chris/0000-0001-9985-9816\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000330252500016},\n}\n\n
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\n \n\n \n \n \n \n \n The Role of Protein Structural Analysis in the Next Generation Sequencing Era.\n \n \n \n\n\n \n Yue, W. W.; Froese, D. S.; and Brennan, P. E.\n\n\n \n\n\n\n In Tang, N.; and Poon, T, editor(s), CHEMICAL DIAGNOSTICS: FROM BENCH TO BEDSIDE, volume 336, of Topics in Current Chemistry-Series, pages 67-98. 2014.\n \n\n\n\n
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@incollection{ WOS:000331048900005,\nAuthor = {Yue, Wyatt W. and Froese, D. Sean and Brennan, Paul E.},\nEditor = {Tang, NLS and Poon, T},\nTitle = {The Role of Protein Structural Analysis in the Next Generation\n   Sequencing Era},\nBooktitle = {CHEMICAL DIAGNOSTICS: FROM BENCH TO BEDSIDE},\nSeries = {Topics in Current Chemistry-Series},\nYear = {2014},\nVolume = {336},\nPages = {67-98},\nDOI = {10.1007/128\\_2012\\_326},\nISSN = {0340-1022},\nISBN = {978-3-642-39942-8; 978-3-642-39941-1},\nResearcherID-Numbers = {Froese, D. Sean/AAW-6899-2021\n   Froese, D. Sean/J-6665-2017},\nORCID-Numbers = {Yue, Wyatt/0000-0001-6959-6007\n   Froese, D. Sean/0000-0003-1557-3517},\nUnique-ID = {WOS:000331048900005},\n}\n\n
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\n \n\n \n \n \n \n \n Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.\n \n \n \n\n\n \n England, K. S.; Tumber, A.; Krojer, T.; Scozzafava, G.; Ng, S. S.; Daniel, M.; Szykowska, A.; Che, K.; von Delft, F.; Burgess-Brown, N. A.; Kawamura, A.; Schofield, C. J.; and Brennan, P. E.\n\n\n \n\n\n\n MEDCHEMCOMM, 5(12): 1879-1886. 2014.\n \n\n\n\n
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@article{ WOS:000345455600013,\nAuthor = {England, Katherine S. and Tumber, Anthony and Krojer, Tobias and\n   Scozzafava, Giuseppe and Ng, Stanley S. and Daniel, Michelle and\n   Szykowska, Aleksandra and Che, KaHing and von Delft, Frank and\n   Burgess-Brown, Nicola A. and Kawamura, Akane and Schofield, Christopher\n   J. and Brennan, Paul E.},\nTitle = {Optimisation of a triazolopyridine based histone demethylase inhibitor\n   yields a potent and selective KDM2A (FBXL11) inhibitor},\nJournal = {MEDCHEMCOMM},\nYear = {2014},\nVolume = {5},\nNumber = {12},\nPages = {1879-1886},\nDOI = {10.1039/c4md00291a},\nISSN = {2040-2503},\nEISSN = {2040-2511},\nResearcherID-Numbers = {Krojer, Tobias/ABE-3829-2021\n   Kawamura, Akane/I-4047-2018\n   },\nORCID-Numbers = {Kawamura, Akane/0000-0003-1169-5082\n   Krojer, Tobias/0000-0003-0661-0814\n   Schofield, Chris/0009-0008-4988-0199\n   von Delft, Frank/0000-0003-0378-0017\n   Schofield, Christopher/0000-0002-0290-6565\n   England, Katherine/0000-0002-4921-7505},\nUnique-ID = {WOS:000345455600013},\n}\n\n
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\n  \n 2013\n \n \n (7)\n \n \n
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\n \n\n \n \n \n \n \n RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.\n \n \n \n\n\n \n Picaud, S.; Wells, C.; Felletar, I.; Brotherton, D.; Martin, S.; Savitsky, P.; Diez-Dacal, B.; Philpott, M.; Bountra, C.; Lingard, H.; Fedorov, O.; Mueller, S.; Brennan, P. E.; Knapp, S.; and Filippakopoulos, P.\n\n\n \n\n\n\n PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 110(49): 19754-19759. DEC 3 2013.\n \n\n\n\n
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@article{ WOS:000327744900034,\nAuthor = {Picaud, Sarah and Wells, Christopher and Felletar, Ildiko and\n   Brotherton, Deborah and Martin, Sarah and Savitsky, Pavel and\n   Diez-Dacal, Beatriz and Philpott, Martin and Bountra, Chas and Lingard,\n   Hannah and Fedorov, Oleg and Mueller, Susanne and Brennan, Paul E. and\n   Knapp, Stefan and Filippakopoulos, Panagis},\nTitle = {RVX-208, an inhibitor of BET transcriptional regulators with selectivity\n   for the second bromodomain},\nJournal = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF\n   AMERICA},\nYear = {2013},\nVolume = {110},\nNumber = {49},\nPages = {19754-19759},\nMonth = {DEC 3},\nDOI = {10.1073/pnas.1310658110},\nISSN = {0027-8424},\nResearcherID-Numbers = {Brown, Tom/A-6655-2010\n   Knapp, Stefan/AAG-2347-2019\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Lingard, Hannah/0000-0003-2571-2496\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Brennan, Paul/0000-0002-8950-7646\n   Savitsky, Pavel/0000-0001-8584-7750\n   Knapp, Stefan/0000-0001-5995-6494\n   Wells-Holland, Chris/0000-0001-9985-9816\n   Fedorov, Oleg/0000-0001-9004-1815\n   Philpott, Martin/0000-0003-3632-0084\n   Muller-Knapp, Susanne/0000-0003-2402-4157},\nUnique-ID = {WOS:000327744900034},\n}\n\n
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\n \n\n \n \n \n \n \n Fragment-based hit identification: thinking in 3D.\n \n \n \n\n\n \n Morley, A. D.; Pugliese, A.; Birchall, K.; Bower, J.; Brennan, P.; Brown, N.; Chapman, T.; Drysdale, M.; Gilbert, I. H.; Hoelder, S.; Jordan, A.; Ley, S. V.; Merritt, A.; Miller, D.; Swarbrick, M. E.; and Wyatt, P. G.\n\n\n \n\n\n\n DRUG DISCOVERY TODAY, 18(23-24): 1221-1227. DEC 2013.\n \n\n\n\n
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@article{ WOS:000328876500011,\nAuthor = {Morley, Andrew D. and Pugliese, Angelo and Birchall, Kristian and Bower,\n   Justin and Brennan, Paul and Brown, Nathan and Chapman, Tim and\n   Drysdale, Martin and Gilbert, Ian H. and Hoelder, Swen and Jordan, Allan\n   and Ley, Steven V. and Merritt, Andy and Miller, David and Swarbrick,\n   Martin E. and Wyatt, Paul G.},\nTitle = {Fragment-based hit identification: thinking in 3D},\nJournal = {DRUG DISCOVERY TODAY},\nYear = {2013},\nVolume = {18},\nNumber = {23-24},\nPages = {1221-1227},\nMonth = {DEC},\nDOI = {10.1016/j.drudis.2013.07.011},\nISSN = {1359-6446},\nEISSN = {1878-5832},\nResearcherID-Numbers = {pugliese, angelo/C-1729-2008\n   Gilbert, Ian/HQY-5739-2023\n   Ley, Steven/O-7712-2016\n   Brown, Nathan/I-7711-2016},\nORCID-Numbers = {Gilbert, Ian/0000-0002-5238-1314\n   Ley, Steven/0000-0002-7816-0042\n   Brennan, Paul/0000-0002-8950-7646\n   Jordan, Allan/0000-0003-3449-3993\n   Wyatt, Paul/0000-0002-0397-245X\n   Brown, Nathan/0000-0001-9243-8699},\nUnique-ID = {WOS:000328876500011},\n}\n\n
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\n \n\n \n \n \n \n \n Chemical probes for bromodomains outside the BET family.\n \n \n \n\n\n \n Brennan, P. E.; Martin, S. J.; Monteiro, O.; Fedorov, O.; Knapp, S.; Hay, D.; Wells, C.; Filippakopoulos, P.; Picaud, S.; Muller-Knapp, S.; Keates, T.; Yapp, C.; Philpott, M.; Schofield, C.; Burgess-Brown, N.; Shrestha, L.; and Strain-Damerell, C.\n\n\n \n\n\n\n ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 246. SEP 8 2013.\n 246th National Meeting of the American-Chemical-Society (ACS), Indianapolis, IN, SEP 08-12, 2013\n\n\n\n
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@article{ WOS:000329618404684,\nAuthor = {Brennan, Paul E. and Martin, Sarah J. and Monteiro, Octovia and Fedorov,\n   Oleg and Knapp, Stefan and Hay, Duncan and Wells, Chris and\n   Filippakopoulos, Panagis and Picaud, Sarah and Muller-Knapp, Susanne and\n   Keates, Tracy and Yapp, Clarence and Philpott, Martin and Schofield,\n   Chris and Burgess-Brown, Nicola and Shrestha, Leela and Strain-Damerell,\n   Claire},\nTitle = {Chemical probes for bromodomains outside the BET family},\nJournal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2013},\nVolume = {246},\nMeeting = {23-MEDI},\nMonth = {SEP 8},\nNote = {246th National Meeting of the American-Chemical-Society (ACS),\n   Indianapolis, IN, SEP 08-12, 2013},\nOrganization = {Amer Chem Soc},\nISSN = {0065-7727},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Martin, Seamus/F-6701-2013\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000329618404684},\n}\n\n
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\n \n\n \n \n \n \n \n PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains.\n \n \n \n\n\n \n Picaud, S.; Da Costa, D.; Thanasopoulou, A.; Filippakopoulos, P.; Fish, P. V.; Philpott, M.; Fedorov, O.; Brennan, P.; Bunnage, M. E.; Owen, D. R.; Bradner, J. E.; Taniere, P.; O'Sullivan, B.; Mueller, S.; Schwaller, J.; Stankovic, T.; and Knapp, S.\n\n\n \n\n\n\n CANCER RESEARCH, 73(11): 3336-3346. JUN 1 2013.\n \n\n\n\n
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@article{ WOS:000319736800015,\nAuthor = {Picaud, Sarah and Da Costa, David and Thanasopoulou, Angeliki and\n   Filippakopoulos, Panagis and Fish, Paul V. and Philpott, Martin and\n   Fedorov, Oleg and Brennan, Paul and Bunnage, Mark E. and Owen, Dafydd R.\n   and Bradner, James E. and Taniere, Philippe and O'Sullivan, Brendan and\n   Mueller, Susanne and Schwaller, Juerg and Stankovic, Tatjana and Knapp,\n   Stefan},\nTitle = {PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET\n   Bromodomains},\nJournal = {CANCER RESEARCH},\nYear = {2013},\nVolume = {73},\nNumber = {11},\nPages = {3336-3346},\nMonth = {JUN 1},\nDOI = {10.1158/0008-5472.CAN-12-3292},\nISSN = {0008-5472},\nEISSN = {1538-7445},\nResearcherID-Numbers = {Brown, Tom/A-6655-2010\n   Stankovic, Tatjana/AHA-2713-2022\n   Knapp, Stefan/AAG-2347-2019\n   Schwaller, Juerg/A-3044-2016\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Bunnage, Mark/0009-0002-6063-8041\n   Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Fedorov, Oleg/0000-0001-9004-1815\n   Stankovic, Tatjana/0000-0002-3780-274X\n   Philpott, Martin/0000-0003-3632-0084\n   Knapp, Stefan/0000-0001-5995-6494\n   Filippakopoulos, Panagis/0000-0002-1515-1317},\nUnique-ID = {WOS:000319736800015},\n}\n\n
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\n \n\n \n \n \n \n \n Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands.\n \n \n \n\n\n \n Hewings, D. S.; Fedorov, O.; Filippakopoulos, P.; Martin, S.; Picaud, S.; Tumber, A.; Wells, C.; Olcina, M. M.; Freeman, K.; Gill, A.; Ritchie, A. J.; Sheppard, D. W.; Russell, A. J.; Hammond, E. M.; Knapp, S.; Brennan, P. E.; and Conway, S. J.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 56(8): 3217-3227. APR 25 2013.\n \n\n\n\n
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@article{ WOS:000318211100007,\nAuthor = {Hewings, David S. and Fedorov, Oleg and Filippakopoulos, Panagis and\n   Martin, Sarah and Picaud, Sarah and Tumber, Anthony and Wells,\n   Christopher and Olcina, Monica M. and Freeman, Katherine and Gill,\n   Andrew and Ritchie, Alison J. and Sheppard, David W. and Russell, Angela\n   J. and Hammond, Ester M. and Knapp, Stefan and Brennan, Paul E. and\n   Conway, Stuart J.},\nTitle = {Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain\n   Ligands},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2013},\nVolume = {56},\nNumber = {8},\nPages = {3217-3227},\nMonth = {APR 25},\nDOI = {10.1021/jm301588r},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Conway, Stuart/AAP-3526-2020\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Filippakopoulos, Panagis/0000-0002-1515-1317\n   Knapp, Stefan/0000-0001-5995-6494\n   Russell, Angela/0000-0003-3610-9369\n   Conway, Stuart/0000-0002-5148-117X\n   Hammond, Ester/0000-0002-2335-3146\n   Hewings, David/0000-0001-9451-8959\n   Fedorov, Oleg/0000-0001-9004-1815\n   Wells-Holland, Chris/0000-0001-9985-9816},\nUnique-ID = {WOS:000318211100007},\n}\n\n
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\n \n\n \n \n \n \n \n The design and synthesis of 5-and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains.\n \n \n \n\n\n \n Hay, D.; Fedorov, O.; Filippakopoulos, P.; Martin, S.; Philpott, M.; Picaud, S.; Hewings, D. S.; Uttakar, S.; Heightman, T. D.; Conway, S. J.; Knapp, S.; and Brennan, P. E.\n\n\n \n\n\n\n MEDCHEMCOMM, 4(1): 140-144. JAN 2013.\n \n\n\n\n
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@article{ WOS:000312547200020,\nAuthor = {Hay, Duncan and Fedorov, Oleg and Filippakopoulos, Panagis and Martin,\n   Sarah and Philpott, Martin and Picaud, Sarah and Hewings, David S. and\n   Uttakar, Sagar and Heightman, Tom D. and Conway, Stuart J. and Knapp,\n   Stefan and Brennan, Paul E.},\nTitle = {The design and synthesis of 5-and 6-isoxazolylbenzimidazoles as\n   selective inhibitors of the BET bromodomains},\nJournal = {MEDCHEMCOMM},\nYear = {2013},\nVolume = {4},\nNumber = {1},\nPages = {140-144},\nMonth = {JAN},\nDOI = {10.1039/c2md20189e},\nISSN = {2040-2503},\nEISSN = {2040-2511},\nResearcherID-Numbers = {Brown, Tom/A-6655-2010\n   Knapp, Stefan/AAG-2347-2019\n   Conway, Stuart/AAP-3526-2020\n   Fedorov, Oleg/B-6412-2014},\nORCID-Numbers = {Knapp, Stefan/0000-0001-5995-6494\n   Conway, Stuart/0000-0002-5148-117X\n   Philpott, Martin/0000-0003-3632-0084\n   Hewings, David/0000-0001-9451-8959\n   Filippakopoulos, Panagis/0000-0002-1515-1317\n   Brennan, Paul/0000-0002-8950-7646\n   Fedorov, Oleg/0000-0001-9004-1815},\nUnique-ID = {WOS:000312547200020},\n}\n\n
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\n \n\n \n \n \n \n \n 5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation.\n \n \n \n\n\n \n Hopkinson, R. J.; Tumber, A.; Yapp, C.; Chowdhury, R.; Aik, W.; Che, K. H.; Li, X. S.; Kristensen, J. B. L.; King, O. N. F.; Chan, M. C.; Yeoh, K. K.; Choi, H.; Walport, L. J.; Thinnes, C. C.; Bush, J. T.; Lejeune, C.; Rydzik, A. M.; Rose, N. R.; Bagg, E. A.; McDonough, M. A.; Krojer, T. J.; Yue, W. W.; Ng, S. S.; Olsen, L.; Brennan, P. E.; Oppermann, U.; Mueller, S.; Klose, R. J.; Ratcliffe, P. J.; Schofield, C. J.; and Kawamura, A.\n\n\n \n\n\n\n CHEMICAL SCIENCE, 4(8): 3110-3117. 2013.\n \n\n\n\n
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@article{ WOS:000321307000014,\nAuthor = {Hopkinson, Richard J. and Tumber, Anthony and Yapp, Clarence and\n   Chowdhury, Rasheduzzaman and Aik, WeiShen and Che, Ka Hing and Li, Xuan\n   Shirley and Kristensen, Jan B. L. and King, Oliver N. F. and Chan, Mun\n   Chiang and Yeoh, Kar Kheng and Choi, Hwanho and Walport, Louise J. and\n   Thinnes, Cyrille C. and Bush, Jacob T. and Lejeune, Clarisse and Rydzik,\n   Anna M. and Rose, Nathan R. and Bagg, Eleanor A. and McDonough, Michael\n   A. and Krojer, Tobias J. and Yue, Wyatt W. and Ng, Stanley S. and Olsen,\n   Lars and Brennan, Paul E. and Oppermann, Udo and Mueller, Susanne and\n   Klose, Robert J. and Ratcliffe, Peter J. and Schofield, Christopher J.\n   and Kawamura, Akane},\nTitle = {5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate\n   oxygenase inhibitor which causes iron translocation},\nJournal = {CHEMICAL SCIENCE},\nYear = {2013},\nVolume = {4},\nNumber = {8},\nPages = {3110-3117},\nDOI = {10.1039/c3sc51122g},\nISSN = {2041-6520},\nEISSN = {2041-6539},\nResearcherID-Numbers = {Li, Bingshan/ABE-6104-2020\n   Krojer, Tobias/ABE-3829-2021\n   Knapp, Stefan/AAG-2347-2019\n   Rydzik, Anna/V-1178-2019\n   McDonough, Michael/N-8913-2019\n   Olsen, Lars/AAY-8278-2020\n   Walport, Louise/ABB-3578-2020\n   Chan, Mun/T-4867-2019\n   Chowdhury, Rasheduzzaman/I-7697-2014\n   Rose, Nathan/A-9270-2013\n   Kawamura, Akane/I-4047-2018\n   McDonough, Michael/G-2744-2013\n   Hopkinson, Richard/K-8372-2013\n   },\nORCID-Numbers = {Bagg, Eleanor/0000-0001-9209-1891\n   Yue, Wyatt/0000-0001-6959-6007\n   Chowdhury, Rasheduzzaman/0000-0002-8058-6149\n   Krojer, Tobias/0000-0003-0661-0814\n   Schofield, Chris/0009-0008-4988-0199\n   Chan, Mun Chiang/0000-0002-3162-6036\n   Olsen, Lars/0000-0002-7607-7130\n   Aik, Wei Shen/0000-0003-4414-173X\n   Bush, Jacob/0000-0001-7165-0092\n   Rydzik, Anna/0000-0003-3158-0493\n   Rose, Nathan/0000-0002-1871-1156\n   Kawamura, Akane/0000-0003-1169-5082\n   Walport, Louise/0000-0002-3795-8365\n   Schofield, Christopher/0000-0002-0290-6565\n   King, Oliver/0000-0002-6152-7207\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   McDonough, Michael/0000-0003-4664-6942\n   Hopkinson, Richard/0000-0001-7610-8163\n   Ratcliffe, Peter/0000-0002-2853-806X},\nUnique-ID = {WOS:000321307000014},\n}\n\n
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\n  \n 2012\n \n \n (6)\n \n \n
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\n \n\n \n \n \n \n \n Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions.\n \n \n \n\n\n \n Hewings, D. S.; Rooney, T. P. C.; Jennings, L. E.; Hay, D. A.; Schofield, C. J.; Brennan, P. E.; Knapp, S.; and Conway, S. J.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 55(22): 9393-9413. NOV 22 2012.\n \n\n\n\n
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@article{ WOS:000311461500002,\nAuthor = {Hewings, David S. and Rooney, Timothy P. C. and Jennings, Laura E. and\n   Hay, Duncan A. and Schofield, Christopher J. and Brennan, Paul E. and\n   Knapp, Stefan and Conway, Stuart J.},\nTitle = {Progress in the Development and Application of Small Molecule Inhibitors\n   of Bromodomain-Acetyl-lysine Interactions},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2012},\nVolume = {55},\nNumber = {22},\nPages = {9393-9413},\nMonth = {NOV 22},\nDOI = {10.1021/jm300915b},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Conway, Stuart/AAP-3526-2020\n   Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {Schofield, Chris/0009-0008-4988-0199\n   Conway, Stuart/0000-0002-5148-117X\n   Schofield, Christopher/0000-0002-0290-6565\n   Hewings, David/0000-0001-9451-8959\n   Knapp, Stefan/0000-0001-5995-6494\n   Rooney, Timothy/0000-0001-6788-5526\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000311461500002},\n}\n\n
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\n \n\n \n \n \n \n \n Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit.\n \n \n \n\n\n \n Fish, P. V.; Filippakopoulos, P.; Bish, G.; Brennan, P. E.; Bunnage, M. E.; Cook, A. S.; Federov, O.; Gerstenberger, B. S.; Jones, H.; Knapp, S.; Marsden, B.; Nocka, K.; Owen, D. R.; Philpott, M.; Picaud, S.; Primiano, M. J.; Ralph, M. J.; Sciammetta, N.; and Trzupek, J. D.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 55(22): 9831-9837. NOV 22 2012.\n \n\n\n\n
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@article{ WOS:000311461500035,\nAuthor = {Fish, Paul V. and Filippakopoulos, Panagis and Bish, Gerwyn and Brennan,\n   Paul E. and Bunnage, Mark E. and Cook, Andrew S. and Federov, Oleg and\n   Gerstenberger, Brian S. and Jones, Hannah and Knapp, Stefan and Marsden,\n   Brian and Nocka, Karl and Owen, Dafydd R. and Philpott, Martin and\n   Picaud, Sarah and Primiano, Michael J. and Ralph, Michael J. and\n   Sciammetta, Nunzio and Trzupek, John D.},\nTitle = {Identification of a Chemical Probe for Bromo and Extra C-Terminal\n   Bromodomain Inhibition through Optimization of a Fragment-Derived Hit},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2012},\nVolume = {55},\nNumber = {22},\nPages = {9831-9837},\nMonth = {NOV 22},\nDOI = {10.1021/jm3010515},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Brown, Tom/A-6655-2010\n   Primiano, Michael/HPD-4541-2023\n   Jones, Hannah/AAM-5162-2020\n   Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {Filippakopoulos, Panagis/0000-0002-1515-1317\n   Knapp, Stefan/0000-0001-5995-6494\n   Philpott, Martin/0000-0003-3632-0084\n   Bunnage, Mark/0009-0002-6063-8041},\nUnique-ID = {WOS:000311461500035},\n}\n\n
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\n \n\n \n \n \n \n \n Developing small molecule inhibitors of the CREBBP bromodomain-histone interaction.\n \n \n \n\n\n \n Rooney, T. P. C.; Fedorov, O.; Filippakopoulos, P.; Wang, M.; Philpott, M.; Cook, A.; Heightman, T. D.; Knapp, S.; Pryde, D.; Brennan, P. E.; and Conway, S. J.\n\n\n \n\n\n\n ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 244. AUG 19 2012.\n 244th National Fall Meeting of the American-Chemical-Society (ACS), Philadelphia, PA, AUG 19-23, 2012\n\n\n\n
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@article{ WOS:000324621806042,\nAuthor = {Rooney, Timothy P. C. and Fedorov, Oleg and Filippakopoulos, Panagis and\n   Wang, Minghua and Philpott, Martin and Cook, Andrew and Heightman, Tom\n   D. and Knapp, Stefan and Pryde, David and Brennan, Paul E. and Conway,\n   Stuart J.},\nTitle = {Developing small molecule inhibitors of the CREBBP bromodomain-histone\n   interaction},\nJournal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2012},\nVolume = {244},\nMeeting = {314-MEDI},\nMonth = {AUG 19},\nNote = {244th National Fall Meeting of the American-Chemical-Society (ACS),\n   Philadelphia, PA, AUG 19-23, 2012},\nOrganization = {Amer Chem Soc, Div Hist Chem; Amer Chem Soc; Amer Chem Soc, Div Chem\n   Educ; Amer Chem Soc, Div Inorgan Chem; Soc Biol Inorgan Chem; Amer Chem\n   Soc, Div Polymer Chem Inc},\nISSN = {0065-7727},\nResearcherID-Numbers = {Wang, Ming/ISV-2749-2023\n   Cook, Andrew/A-8652-2015\n   Fedorov, Oleg/B-6412-2014\n   Conway, Stuart/AAP-3526-2020\n   Knapp, Stefan/AAG-2347-2019\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000324621806042},\n}\n\n
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\n \n\n \n \n \n \n \n Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases.\n \n \n \n\n\n \n Rose, N. R.; Woon, E. C. Y.; Tumber, A.; Walport, L. J.; Chowdhury, R.; Li, X. S.; King, O. N. F.; Lejeune, C.; Ng, S. S.; Krojer, T.; Chan, M. C.; Rydzik, A. M.; Hopkinson, R. J.; Che, K. H.; Daniel, M.; Strain-Damerell, C.; Gileadi, C.; Kochan, G.; Leung, I. K. H.; Dunford, J.; Yeoh, K. K.; Ratcliffe, P. J.; Burgess-Brown, N.; von Delft, F.; Muller, S.; Marsden, B.; Brennan, P. E.; McDonough, M. A.; Oppermann, U.; Klose, R. J.; Schofield, C. J.; and Kawamura, A.\n\n\n \n\n\n\n JOURNAL OF MEDICINAL CHEMISTRY, 55(14): 6639-6643. JUL 26 2012.\n \n\n\n\n
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@article{ WOS:000306764600036,\nAuthor = {Rose, Nathan R. and Woon, Esther C. Y. and Tumber, Anthony and Walport,\n   Louise J. and Chowdhury, Rasheduzzaman and Li, Xuan Shirley and King,\n   Oliver N. F. and Lejeune, Clarisse and Ng, Stanley S. and Krojer, Tobias\n   and Chan, Mun Chiang and Rydzik, Anna M. and Hopkinson, Richard J. and\n   Che, Ka Hing and Daniel, Michelle and Strain-Damerell, Claire and\n   Gileadi, Carina and Kochan, Grazyna and Leung, Ivanhoe K. H. and\n   Dunford, James and Yeoh, Kar Kheng and Ratcliffe, Peter J. and\n   Burgess-Brown, Nicola and von Delft, Frank and Muller, Susanne and\n   Marsden, Brian and Brennan, Paul E. and McDonough, Michael A. and\n   Oppermann, Udo and Klose, Robert J. and Schofield, Christopher J. and\n   Kawamura, Akane},\nTitle = {Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human\n   KDM2/7 Histone Demethylases},\nJournal = {JOURNAL OF MEDICINAL CHEMISTRY},\nYear = {2012},\nVolume = {55},\nNumber = {14},\nPages = {6639-6643},\nMonth = {JUL 26},\nDOI = {10.1021/jm300677j},\nISSN = {0022-2623},\nEISSN = {1520-4804},\nResearcherID-Numbers = {Chan, Mun/T-4867-2019\n   Leung, Ivanhoe/G-6168-2010\n   Rydzik, Anna/V-1178-2019\n   Li, Bingshan/ABE-6104-2020\n   McDonough, Michael/N-8913-2019\n   Kochan, Grazyna/A-1094-2009\n   Krojer, Tobias/ABE-3829-2021\n   Walport, Louise/ABB-3578-2020\n   McDonough, Michael/G-2744-2013\n   Rose, Nathan/A-9270-2013\n   Kawamura, Akane/I-4047-2018\n   Woon, Esther/C-3537-2016\n   Chowdhury, Rasheduzzaman/I-7697-2014\n   Hopkinson, Richard/K-8372-2013\n   },\nORCID-Numbers = {Rydzik, Anna/0000-0003-3158-0493\n   Dunford, James/0000-0002-9932-4042\n   von Delft, Frank/0000-0003-0378-0017\n   McDonough, Michael/0000-0003-4664-6942\n   Kochan, Grazyna/0000-0002-0534-9661\n   Walport, Louise/0000-0002-3795-8365\n   Ratcliffe, Peter/0000-0002-2853-806X\n   Rose, Nathan/0000-0002-1871-1156\n   Leung, Ivanhoe/0000-0003-0633-6771\n   Kawamura, Akane/0000-0003-1169-5082\n   Brennan, Paul/0000-0002-8950-7646\n   Muller-Knapp, Susanne/0000-0003-2402-4157\n   Chan, Mun Chiang/0000-0002-3162-6036\n   Woon, Esther/0000-0001-7501-2872\n   Krojer, Tobias/0000-0003-0661-0814\n   Schofield, Chris/0009-0008-4988-0199\n   Chowdhury, Rasheduzzaman/0000-0002-8058-6149\n   Hopkinson, Richard/0000-0001-7610-8163\n   Schofield, Christopher/0000-0002-0290-6565\n   King, Oliver/0000-0002-6152-7207},\nUnique-ID = {WOS:000306764600036},\n}\n\n
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\n \n\n \n \n \n \n \n 3,5-Dimethylisoxazoles inhibit the bromodomain-histone protein-protein interaction.\n \n \n \n\n\n \n Hewings, D. S.; Wang, M.; Philpott, M.; Fedorov, O.; Uttarkar, S.; Filippakopoulos, P.; Picaud, S.; Vuppusetty, C.; Marsden, B.; Heightman, T. D.; Knapp, S.; Brennan, P.; and Conway, S. J.\n\n\n \n\n\n\n ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243. MAR 25 2012.\n 243rd National Spring Meeting of the American-Chemical-Society, San Diego, CA, MAR 25-29, 2012\n\n\n\n
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@article{ WOS:000324503201975,\nAuthor = {Hewings, David S. and Wang, Minghua and Philpott, Martin and Fedorov,\n   Oleg and Uttarkar, Sagar and Filippakopoulos, Panagis and Picaud, Sarah\n   and Vuppusetty, Chaitanya and Marsden, Brian and Heightman, Tom D. and\n   Knapp, Stefan and Brennan, Paul and Conway, Stuart J.},\nTitle = {3,5-Dimethylisoxazoles inhibit the bromodomain-histone protein-protein\n   interaction},\nJournal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2012},\nVolume = {243},\nMeeting = {326-MEDI},\nMonth = {MAR 25},\nNote = {243rd National Spring Meeting of the American-Chemical-Society, San\n   Diego, CA, MAR 25-29, 2012},\nOrganization = {Amer Chem Soc},\nISSN = {0065-7727},\nResearcherID-Numbers = {Knapp, Stefan/AAG-2347-2019\n   Wang, Minghua/LLK-7229-2024\n   Conway, Stuart/AAP-3526-2020\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000324503201975},\n}\n\n
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\n \n\n \n \n \n \n \n Developing chemical probes for the BET bromodomains.\n \n \n \n\n\n \n Hewings, D. S.; Wang, M.; Philpott, M.; Fedorov, O.; Uttarkar, S.; Filippakopoulos, P.; Picaud, S.; Vuppusetty, C.; Marsden, B.; Heightman, T. D.; Knapp, S.; Brennan, P.; and Conway, S. J.\n\n\n \n\n\n\n ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 243. MAR 25 2012.\n 243rd National Spring Meeting of the American-Chemical-Society, San Diego, CA, MAR 25-29, 2012\n\n\n\n
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@article{ WOS:000324503201772,\nAuthor = {Hewings, David S. and Wang, Minghua and Philpott, Martin and Fedorov,\n   Oleg and Uttarkar, Sagar and Filippakopoulos, Panagis and Picaud, Sarah\n   and Vuppusetty, Chaitanya and Marsden, Brian and Heightman, Tom D. and\n   Knapp, Stefan and Brennan, Paul and Conway, Stuart J.},\nTitle = {Developing chemical probes for the BET bromodomains},\nJournal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2012},\nVolume = {243},\nMeeting = {116-MEDI},\nMonth = {MAR 25},\nNote = {243rd National Spring Meeting of the American-Chemical-Society, San\n   Diego, CA, MAR 25-29, 2012},\nOrganization = {Amer Chem Soc},\nISSN = {0065-7727},\nResearcherID-Numbers = {Conway, Stuart/AAP-3526-2020\n   Knapp, Stefan/AAG-2347-2019\n   Wang, Ming/ISV-2749-2023\n   Fedorov, Oleg/B-6412-2014\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000324503201772},\n}\n\n
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\n  \n 2011\n \n \n (2)\n \n \n
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\n \n\n \n \n \n \n \n Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.\n \n \n \n\n\n \n Andrews, M. D.; Fish, P. V.; Blagg, J.; Brabham, T. K.; Brennan, P. E.; Bridgeland, A.; Brown, A. D.; Bungay, P. J.; Conlon, K. M.; Edmunds, N. J.; af Forselles, K.; Gibbons, C. P.; Green, M. P.; Hanton, G.; Holbrook, M.; Jessiman, A. S.; McIntosh, K.; McMurray, G.; Nichols, C. L.; Root, J. A.; Storer, R. I.; Sutton, M. R.; Ward, R. V.; Westbrook, D.; and Whitlock, G. A.\n\n\n \n\n\n\n BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(9): 2715-2720. MAY 1 2011.\n \n\n\n\n
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@article{ WOS:000289773300029,\nAuthor = {Andrews, Mark D. and Fish, Paul V. and Blagg, Julian and Brabham,\n   Tiffini K. and Brennan, Paul E. and Bridgeland, Alison and Brown, Alan\n   D. and Bungay, Peter J. and Conlon, Kelly M. and Edmunds, Nicholas J.\n   and af Forselles, Kerry and Gibbons, Colleen P. and Green, Martin P. and\n   Hanton, Giles and Holbrook, Mark and Jessiman, Alan S. and McIntosh,\n   Karin and McMurray, Gordon and Nichols, Carly L. and Root, James A. and\n   Storer, R. Ian and Sutton, Michael R. and Ward, Robin V. and Westbrook,\n   Dominique and Whitlock, Gavin A.},\nTitle = {Pyrimido{[}4,5-d]azepines as potent and selective\n   5-HT2C receptor agonists: Design, synthesis, and evaluation\n   of PF-3246799 as a treatment for urinary incontinence},\nJournal = {BIOORGANIC \\& MEDICINAL CHEMISTRY LETTERS},\nYear = {2011},\nVolume = {21},\nNumber = {9},\nPages = {2715-2720},\nMonth = {MAY 1},\nDOI = {10.1016/j.bmcl.2010.11.120},\nISSN = {0960-894X},\nEISSN = {1464-3405},\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000289773300029},\n}\n\n
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\n \n\n \n \n \n \n \n A tandem asymmetric synthesis approach for the efficient preparation of enantiomerically pure 9-(hydroxyethyl) anthracene.\n \n \n \n\n\n \n Ball, J. C.; Brennan, P.; Elsunaki, T. M.; Jaunet, A.; and Jones, S.\n\n\n \n\n\n\n TETRAHEDRON-ASYMMETRY, 22(3): 253-255. FEB 10 2011.\n \n\n\n\n
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@article{ WOS:000290074800001,\nAuthor = {Ball, Jennifer C. and Brennan, Paul and Elsunaki, Tareg M. and Jaunet,\n   Alexis and Jones, Simon},\nTitle = {A tandem asymmetric synthesis approach for the efficient preparation of\n   enantiomerically pure 9-(hydroxyethyl) anthracene},\nJournal = {TETRAHEDRON-ASYMMETRY},\nYear = {2011},\nVolume = {22},\nNumber = {3},\nPages = {253-255},\nMonth = {FEB 10},\nDOI = {10.1016/j.tetasy.2011.01.019},\nISSN = {0957-4166},\nResearcherID-Numbers = {Jones, Simon/F-6940-2010\n   },\nORCID-Numbers = {Jones, Simon/0000-0001-8043-7998\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000290074800001},\n}\n\n
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\n  \n 2009\n \n \n (1)\n \n \n
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\n \n\n \n \n \n \n \n Potent and selective α1A adrenoceptor partial agonists-Novel imidazole frameworks.\n \n \n \n\n\n \n Whitlock, G. A.; Brennan, P. E.; Roberts, L. R.; and Stobie, A.\n\n\n \n\n\n\n BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(11): 3118-3121. JUN 1 2009.\n \n\n\n\n
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@article{ WOS:000265981900050,\nAuthor = {Whitlock, Gavin A. and Brennan, Paul E. and Roberts, Lee R. and Stobie,\n   Alan},\nTitle = {Potent and selective α1A adrenoceptor partial agonists-Novel\n   imidazole frameworks},\nJournal = {BIOORGANIC \\& MEDICINAL CHEMISTRY LETTERS},\nYear = {2009},\nVolume = {19},\nNumber = {11},\nPages = {3118-3121},\nMonth = {JUN 1},\nDOI = {10.1016/j.bmcl.2009.03.162},\nISSN = {0960-894X},\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000265981900050},\n}\n\n
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\n  \n 2003\n \n \n (3)\n \n \n
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\n \n\n \n \n \n \n \n Palladium-containing perovskites: recoverable and reuseable catalysts for Suzuki couplings.\n \n \n \n\n\n \n Smith, M.; Stepan, A.; Ramarao, C; Brennan, P.; and Ley, S.\n\n\n \n\n\n\n CHEMICAL COMMUNICATIONS, (21): 2652-2653. NOV 7 2003.\n \n\n\n\n
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@article{ WOS:000186492000003,\nAuthor = {Smith, MD and Stepan, AF and Ramarao, C and Brennan, PE and Ley, SV},\nTitle = {Palladium-containing perovskites: recoverable and reuseable catalysts\n   for Suzuki couplings},\nJournal = {CHEMICAL COMMUNICATIONS},\nYear = {2003},\nNumber = {21},\nPages = {2652-2653},\nMonth = {NOV 7},\nDOI = {10.1039/b308465e},\nISSN = {1359-7345},\nEISSN = {1364-548X},\nResearcherID-Numbers = {Ley, Steven/O-7712-2016\n   },\nORCID-Numbers = {Ley, Steven/0000-0002-7816-0042\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000186492000003},\n}\n\n
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\n \n\n \n \n \n \n \n Studies toward a total synthesis of bengazole A utilizing BDA-protected building blocks.\n \n \n \n\n\n \n Balskus, E.; Brennan, P.; and Ley, S.\n\n\n \n\n\n\n ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 225(2): U350-U351. MAR 2003.\n 225th National Meeting of the American-Chemical-Society, NEW ORLEANS, LOUISIANA, MAR 23-27, 2003\n\n\n\n
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@article{ WOS:000187918001822,\nAuthor = {Balskus, EP and Brennan, PE and Ley, SV},\nTitle = {Studies toward a total synthesis of bengazole A utilizing BDA-protected\n   building blocks.},\nJournal = {ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY},\nYear = {2003},\nVolume = {225},\nNumber = {2},\nMeeting = {418-ORGN},\nPages = {U350-U351},\nMonth = {MAR},\nNote = {225th National Meeting of the American-Chemical-Society, NEW ORLEANS,\n   LOUISIANA, MAR 23-27, 2003},\nOrganization = {Amer Chem Soc},\nISSN = {0065-7727},\nResearcherID-Numbers = {Ley, Steven/O-7712-2016\n   },\nORCID-Numbers = {Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000187918001822},\n}\n\n
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\n \n\n \n \n \n \n \n Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques.\n \n \n \n\n\n \n MacCoss, R.; Brennan, P.; and Ley, S.\n\n\n \n\n\n\n ORGANIC & BIOMOLECULAR CHEMISTRY, 1(12): 2029-2031. 2003.\n \n\n\n\n
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@article{ WOS:000183433000002,\nAuthor = {MacCoss, RN and Brennan, PE and Ley, SV},\nTitle = {Synthesis of carbohydrate derivatives using solid-phase work-up and\n   scavenging techniques},\nJournal = {ORGANIC \\& BIOMOLECULAR CHEMISTRY},\nYear = {2003},\nVolume = {1},\nNumber = {12},\nPages = {2029-2031},\nDOI = {10.1039/b303951j},\nISSN = {1477-0520},\nEISSN = {1477-0539},\nResearcherID-Numbers = {Ley, Steven/O-7712-2016\n   },\nORCID-Numbers = {Ley, Steven/0000-0002-7816-0042\n   Brennan, Paul/0000-0002-8950-7646},\nUnique-ID = {WOS:000183433000002},\n}\n
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