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\n \n 2025\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Long-term outcome of oesophageal atresia in adolescence (TransEAsome): a national French cohort study protocol.\n \n \n \n \n\n\n \n Leroy, M.; Aumar, M.; Duhamel, M.; Dauchet, L.; Figeac, M.; Gaillard, S.; Hankard, R.; Labreuche, J.; Marot, G.; Reversat, J.; Armand, V.; Salzet, M.; Sfeir, R.; Vandel, J.; and Gottrand, F.\n\n\n \n\n\n\n BMJ open, 15(1): e086303. January 2025.\n \n\n\n\n
\n\n\n\n \n \n $\"Long-term$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{leroy_long-term_2025,\n\ttitle = {Long-term outcome of oesophageal atresia in adolescence ({TransEAsome}): a national {French} cohort study protocol},\n\tvolume = {15},\n\tissn = {2044-6055},\n\tshorttitle = {Long-term outcome of oesophageal atresia in adolescence ({TransEAsome})},\n\turl = {http://hdl.handle.net/20.500.12210/119304},\n\tdoi = {10.1136/bmjopen-2024-086303},\n\tabstract = {INTRODUCTION: The TransEAsome project, funded by the Agence Nationale de la Recherche, aims to evaluate the long-term outcomes of patients with oesophageal atresia (OA) between 13 and 14 years old and establish multiomics profiles using data from the world's biggest OA registry.\nMETHODS AND ANALYSIS: TransEAsome is a national multicentre population-based cohort study recruiting participants from all qualified French centres for OA surgery at birth. The primary objective is to assess the prevalence of gastro-oesophageal reflux disease in adolescence among patients with OA, with several secondary objectives including the identification of risk factors and multiomic profiles from oesophageal biopsies and blood samples collected between 13 and 14 years old, compared with a control group. This comprehensive characterisation of phenotype and omic profiles aims to enhance the understanding of disease evolution in patients with OA and inform tailored care management strategies.\nETHICS AND DISSEMINATION: The study, coconstructed with input from patients, parents and research-expert adolescents, has obtained approval from the ethics research committee: Comité de protection des personnes Est II. Findings will be disseminated to various target audiences, including the scientific community, research participants, the patient community, the general public, regulatory authorities and policymakers. Data will be made available in a Findable, Accessible, Interoperable, Reusable format on the France Cohortes platform on study completion.\nTRIAL REGISTRATION NUMBER: NCT05995171:Clinical trial.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {BMJ open},\n\tauthor = {Leroy, Mélanie and Aumar, Madeleine and Duhamel, Marie and Dauchet, Luc and Figeac, Martin and Gaillard, Segolene and Hankard, Regis and Labreuche, Julien and Marot, Guillemette and Reversat, Julie and Armand, Viviane and Salzet, Michel and Sfeir, Rony and Vandel, Jimmy and Gottrand, Frédéric},\n\tmonth = jan,\n\tyear = {2025},\n\tpmid = {39800411},\n\tkeywords = {Adolescent, Adolescents, Cohort Studies, Esophageal Atresia, Female, France, Gastroesophageal Reflux, Humans, Male, Oesophageal disease, Paediatric gastroenterology, Patient Reported Outcome Measures, Prevalence, Quality of Life, Registries, Research Design, Risk Factors},\n\tpages = {e086303},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n 2024\n \n \n (8)\n \n \n

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\n \n\n \n \n \n \n \n Causal effects of genetically determined metabolites and metabolite ratios on esophageal diseases: a two-sample Mendelian randomization study.\n \n \n \n\n\n \n Yang, H.; Wang, Y.; Zhao, Y.; Cao, L.; Chen, C.; and Yu, W.\n\n\n \n\n\n\n BMC gastroenterology, 24(1): 310. September 2024.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{yang_causal_2024,\n\ttitle = {Causal effects of genetically determined metabolites and metabolite ratios on esophageal diseases: a two-sample {Mendelian} randomization study},\n\tvolume = {24},\n\tissn = {1471-230X},\n\tshorttitle = {Causal effects of genetically determined metabolites and metabolite ratios on esophageal diseases},\n\tdoi = {10.1186/s12876-024-03411-8},\n\tabstract = {BACKGROUND: Esophageal diseases (ED) are a kind of common diseases of upper digestive tract. Previous studies have proved that metabolic disorders are closely related to the occurrence and development of ED. However, there is a lack of evidence for causal relationships between metabolites and ED, as well as between metabolite ratios representing enzyme activities and ED. Herein, we explored the causality of genetically determined metabolites (GDMs) on ED through Mendelian Randomization (MR) study.\nMETHODS: Two-sample Mendelian randomization analysis was used to assess the causal effects of genetically determined metabolites and metabolite ratios on ED. A genome-wide association analysis (GWAS) encompassing 850 individual metabolites along with 309 metabolite ratios served as the exposures. Meanwhile, the outcomes were defined by 10 types of ED phenotypes, including Congenital Malformations of Esophagus (CME), Esophageal Varices (EV), Esophageal Obstructions (EO), Esophageal Ulcers (EU), Esophageal Perforations (EP), Gastroesophageal Reflux Disease (GERD), Esophagitis, Barrett's Esophagus (BE), Benign Esophageal Tumors (BETs), and Malignant Esophageal Neoplasms (MENs). The standard inverse variance weighted (IVW) method was applied to estimate the causal relationship between exposure and outcome. Sensitivity analyses were carried out using multiple methods, including MR-Egger, Weighted Median, MR-PRESSO, Cochran's Q test, and leave-one-out analysis. P {\\textless} 0.05 was conventionally considered statistically significant. After applying the Bonferroni correction for multiple testing, a threshold of P {\\textless} 4.3E-05 (0.05/1159) was regarded as indicative of a statistically significant causal relationship. Furthermore, metabolic pathway analysis was performed using the web-based MetaboAnalyst 6.0 software.\nRESULTS: The findings revealed that initially, a total of 869 candidate causal association pairs ( P ivw   {\\textless} 0.05) were identified, involving 442 metabolites, 145 metabolite ratios and 10 types of ED. However, upon applying the Bonferroni correction for multiple testing, only 36 pairs remained significant, involving 28 metabolites (predominantly lipids and amino acids), 5 metabolite ratios and 6 types of ED. Sensitivity analyses and reverse MR were performed for these 36 causal association pairs, where the results showed that the pair of EV and 1-(1-enyl-palmitoyl)-2-linoleoyl-GPE (p-16:0/18:2) did not withstand the sensitivity tests, and Hexadecenedioate (C16:1-DC) was found to have a reverse causality with GERD. The final 34 robust causal pairs included 26 metabolites, 5 metabolite ratios and 5 types of ED. The involved 26 metabolites predominantly consisted of methylated nucleotides, glycine derivatives, sex hormones, phospholipids, bile acids, fatty acid dicarboxylic acid derivatives, and N-acetylated amino acids. Furthermore, through metabolic pathway analysis, we uncovered 8 significant pathways that played pivotal roles in five types of ED conditions.\nCONCLUSIONS: This study integrated genomics with metabolomics to assess causal relationships between ED and both metabolites and metabolite ratios, uncovering several key metabolic features in ED pathogenesis. These findings have potential as novel biomarkers for ED and provide insights into the disease's etiology and progression. However, further clinical and experimental validations are necessary.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {BMC gastroenterology},\n\tauthor = {Yang, Hanlei and Wang, Yulan and Zhao, Yuewei and Cao, Leiqun and Chen, Changqiang and Yu, Wenjun},\n\tmonth = sep,\n\tyear = {2024},\n\tpmid = {39271994},\n\tpmcid = {PMC11401347},\n\tkeywords = {Causal effects, Causality, Esophageal Diseases, Esophageal diseases, Genome-Wide Association Study, Humans, Mendelian Randomization Analysis, Mendelian randomization, Metabolite ratios, Metabolites, Phenotype, Polymorphism, Single Nucleotide},\n\tpages = {310},\n}\n\n\n\n\n\n\n\n

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\n BACKGROUND: Esophageal diseases (ED) are a kind of common diseases of upper digestive tract. Previous studies have proved that metabolic disorders are closely related to the occurrence and development of ED. However, there is a lack of evidence for causal relationships between metabolites and ED, as well as between metabolite ratios representing enzyme activities and ED. Herein, we explored the causality of genetically determined metabolites (GDMs) on ED through Mendelian Randomization (MR) study. METHODS: Two-sample Mendelian randomization analysis was used to assess the causal effects of genetically determined metabolites and metabolite ratios on ED. A genome-wide association analysis (GWAS) encompassing 850 individual metabolites along with 309 metabolite ratios served as the exposures. Meanwhile, the outcomes were defined by 10 types of ED phenotypes, including Congenital Malformations of Esophagus (CME), Esophageal Varices (EV), Esophageal Obstructions (EO), Esophageal Ulcers (EU), Esophageal Perforations (EP), Gastroesophageal Reflux Disease (GERD), Esophagitis, Barrett's Esophagus (BE), Benign Esophageal Tumors (BETs), and Malignant Esophageal Neoplasms (MENs). The standard inverse variance weighted (IVW) method was applied to estimate the causal relationship between exposure and outcome. Sensitivity analyses were carried out using multiple methods, including MR-Egger, Weighted Median, MR-PRESSO, Cochran's Q test, and leave-one-out analysis. P \\textless 0.05 was conventionally considered statistically significant. After applying the Bonferroni correction for multiple testing, a threshold of P \\textless 4.3E-05 (0.05/1159) was regarded as indicative of a statistically significant causal relationship. Furthermore, metabolic pathway analysis was performed using the web-based MetaboAnalyst 6.0 software. RESULTS: The findings revealed that initially, a total of 869 candidate causal association pairs ( P ivw \\textless 0.05) were identified, involving 442 metabolites, 145 metabolite ratios and 10 types of ED. However, upon applying the Bonferroni correction for multiple testing, only 36 pairs remained significant, involving 28 metabolites (predominantly lipids and amino acids), 5 metabolite ratios and 6 types of ED. Sensitivity analyses and reverse MR were performed for these 36 causal association pairs, where the results showed that the pair of EV and 1-(1-enyl-palmitoyl)-2-linoleoyl-GPE (p-16:0/18:2) did not withstand the sensitivity tests, and Hexadecenedioate (C16:1-DC) was found to have a reverse causality with GERD. The final 34 robust causal pairs included 26 metabolites, 5 metabolite ratios and 5 types of ED. The involved 26 metabolites predominantly consisted of methylated nucleotides, glycine derivatives, sex hormones, phospholipids, bile acids, fatty acid dicarboxylic acid derivatives, and N-acetylated amino acids. Furthermore, through metabolic pathway analysis, we uncovered 8 significant pathways that played pivotal roles in five types of ED conditions. CONCLUSIONS: This study integrated genomics with metabolomics to assess causal relationships between ED and both metabolites and metabolite ratios, uncovering several key metabolic features in ED pathogenesis. These findings have potential as novel biomarkers for ED and provide insights into the disease's etiology and progression. However, further clinical and experimental validations are necessary.\n

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\n \n\n \n \n \n \n \n Navigating global collaboration: challenges faced by the international network on esophageal atresia.\n \n \n \n\n\n \n Gottrand, F.; Krishnan, U.; Widenmann, A.; Blom, M. D.; Dall'Oglio, L.; Wijnen, R.; van Wijk, M.; Fruithof, J.; von Allmen, D.; Kovesi, T.; and Faure, C.\n\n\n \n\n\n\n Orphanet Journal of Rare Diseases, 19(1): 304. August 2024.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gottrand_navigating_2024,\n\ttitle = {Navigating global collaboration: challenges faced by the international network on esophageal atresia},\n\tvolume = {19},\n\tissn = {1750-1172},\n\tshorttitle = {Navigating global collaboration},\n\tdoi = {10.1186/s13023-024-03250-6},\n\tabstract = {The International Network on Esophageal Atresia (INoEA) stands as a beacon of collaboration in addressing the complexities of this congenital condition on a global scale. The eleven board members, from various countries (USA, Canada, France, Australia, Italy, Sweden, Germany, and The Netherlands) and backgrounds (pediatric gastroenterology, pediatric surgery, pediatric pulmonology, nursing, and parents) met in a face-to-face symposium in Lille in November 2023, to identify challenges and solutions for improving global collaboration of the network.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Orphanet Journal of Rare Diseases},\n\tauthor = {Gottrand, Frédéric and Krishnan, Usha and Widenmann, Anke and Blom, Michaela Dellenmark and Dall'Oglio, Luigi and Wijnen, Rene and van Wijk, Michiel and Fruithof, JoAnne and von Allmen, Daniel and Kovesi, Tom and Faure, Christophe},\n\tmonth = aug,\n\tyear = {2024},\n\tpmid = {39169371},\n\tpmcid = {PMC11337619},\n\tkeywords = {Australia, Esophageal Atresia, Esophageal atresia, Gastroenterology, Humans, International Cooperation, Long life disease; transition to adult medicine},\n\tpages = {304},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Time to consider oesophageal atresia as a life-long disease.\n \n \n \n \n\n\n \n Leroy, M.; Aumar, M.; Seguy, D.; Vandamme, F.; Widenmann, A.; Sfeir, R.; and Gottrand, F.\n\n\n \n\n\n\n International Journal of Surgery (London, England), 110(5): 2506–2507. May 2024.\n \n\n\n\n
\n\n\n\n \n \n $\"Time$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{leroy_time_2024,\n\ttitle = {Time to consider oesophageal atresia as a life-long disease},\n\tvolume = {110},\n\tissn = {1743-9159},\n\turl = {http://hdl.handle.net/20.500.12210/109819},\n\tdoi = {10.1097/JS9.0000000000001167},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {International Journal of Surgery (London, England)},\n\tauthor = {Leroy, Mélanie and Aumar, Madeleine and Seguy, David and Vandamme, Florent and Widenmann, Anke and Sfeir, Rony and Gottrand, Frédéric},\n\tmonth = may,\n\tyear = {2024},\n\tpmid = {38376869},\n\tpmcid = {PMC11093440},\n\tkeywords = {Esophageal Atresia, Humans, Infant, Newborn},\n\tpages = {2506--2507},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Proton pump inhibitors in esophageal atresia: A systematic review and meta-analysis.\n \n \n \n \n\n\n \n Dimitrov, G.; Aumar, M.; Duhamel, A.; Wanneveich, M.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 78(3): 457–470. March 2024.\n \n\n\n\n
\n\n\n\n \n \n $\"Proton$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{dimitrov_proton_2024,\n\ttitle = {Proton pump inhibitors in esophageal atresia: {A} systematic review and meta-analysis},\n\tvolume = {78},\n\tissn = {1536-4801},\n\tshorttitle = {Proton pump inhibitors in esophageal atresia},\n\turl = {http://hdl.handle.net/20.500.12210/105660},\n\tdoi = {10.1002/jpn3.12115},\n\tabstract = {Gastroesophageal reflux disease (GERD) is frequent and prolonged in esophageal atresia (EA) pediatric patients requiring routine use of proton pump inhibitors (PPIs). However, there are still controversies on the prophylactic use of PPIs and the efficacy of PPIs on GERD and EA complications in this special condition. The aim of the study is to assess the prophylactic use of PPIs in pediatric patients with EA and its complications. We, therefore, performed a systematic review including all reports on the subject from 1980 to 2022. We conducted meta-analysis of the pooled proportion of PPI-and no PPI groups using random effect model, meta-regression, and estimate heterogeneity by heterogeneity index I2 . Thirty-eight reports on the topic met the criteria selection, representing a cumulative 6044 patients with EA. Prophylactic PPI prescription during the first year of life does not appear to prevent GERD persistence at follow-up and is not associated with a significantly reduced rate of antireflux surgical procedures (ARP). PPIs improve peptic esophagitis and induce remission of eosinophilic esophagitis at a rate of 50\\%. Their effect on other GERD outcomes is uncertain. Evidence suggests that PPIs do not prevent anastomotic stricture, Barrett's esophagus, or respiratory complications. PPI use in EA can improve peptic and eosinophilic esophagitis but is ineffective on the other EA complications. Side effects of PPIs in EA are almost unknown.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Dimitrov, Georges and Aumar, Madeleine and Duhamel, Alain and Wanneveich, Mathilde and Gottrand, Frédéric},\n\tmonth = mar,\n\tyear = {2024},\n\tpmid = {38262739},\n\tkeywords = {Barrett's esophagus, Child, Esophageal Atresia, Gastroesophageal Reflux, Humans, Proton Pump Inhibitors, anastomotic stricture, child, eosinophilic esophagitis, gastroesophageal reflux disease},\n\tpages = {457--470},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Over-the-scope clip for closure of persistent gastrocutaneous fistula after gastrostomy tube removal: a multicenter pediatric experience.\n \n \n \n\n\n \n Corsello, A.; Antoine, M.; Sharma, S.; Bertrand, V.; Oliva, S.; Fava, G.; Destro, F.; Huang, A.; Fong, W. S. W.; Ichino, M.; Thomson, M.; and Gottrand, F.\n\n\n \n\n\n\n Surgical Endoscopy, 38(11): 6305–6311. November 2024.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{corsello_over--scope_2024,\n\ttitle = {Over-the-scope clip for closure of persistent gastrocutaneous fistula after gastrostomy tube removal: a multicenter pediatric experience},\n\tvolume = {38},\n\tissn = {1432-2218},\n\tshorttitle = {Over-the-scope clip for closure of persistent gastrocutaneous fistula after gastrostomy tube removal},\n\tdoi = {10.1007/s00464-024-11166-2},\n\tabstract = {BACKGROUND: Percutaneous endoscopic gastrostomy is commonly used for enteral nutritional access, but gastrocutaneous fistulae (GCF) may persist after tube removal, posing clinical challenges. The use of endoscopic closure devices, including over-the-scope clips (OTSC), has shown promise in managing non-healing fistulae, although data in the pediatric population are limited.\nMETHODS: A retrospective multicenter study analyzed pediatric patients who underwent GCF closure following gastrostomy tube removal. Data from seven centers across multiple countries were collected, including patient demographics, procedural details, complications, and outcomes. Closure techniques were compared between OTSC and surgical closure.\nRESULTS: Of 67 pediatric patients included, 21 underwent OTSC closure and 46 had surgical closure. Surgical closure demonstrated a higher success rate (100\\%) compared to OTSC closure (61.9\\%, P {\\textless} 0.001). While procedural duration was shorter for OTSC closure (25 vs. 40 min, P = 0.002), complications, and scar quality were comparable between techniques. A subsequent sub-analysis did not reveal differences based on center experience.\nCONCLUSION: OTSC closure is feasible and safe in pediatric patients, but surgical closure remains superior in achieving sustained GCF closure, although OTSC offers benefits, such as shorter procedural duration, potentially reducing the duration of general anesthesia exposure. Non-operative approaches, including OTSC, may be a valuable alternative to surgical closure.},\n\tlanguage = {eng},\n\tnumber = {11},\n\tjournal = {Surgical Endoscopy},\n\tauthor = {Corsello, Antonio and Antoine, Matthieu and Sharma, Shishu and Bertrand, Valérie and Oliva, Salvatore and Fava, Giorgio and Destro, Francesca and Huang, Andrew and Fong, Wei S. W. and Ichino, Martina and Thomson, Mike and Gottrand, Frederic},\n\tmonth = nov,\n\tyear = {2024},\n\tpmid = {39187732},\n\tpmcid = {PMC11525288},\n\tkeywords = {Adolescent, Child, Child, Preschool, Closure techniques, Cutaneous Fistula, Device Removal, Enteral Nutrition, Female, Gastric Fistula, Gastrocutaneous fistula, Gastrostomy, Humans, Infant, Male, OTSC, Ovesco, PEG removal, Pediatric surgery, Postoperative Complications, Retrospective Studies, Surgical Instruments, Treatment Outcome},\n\tpages = {6305--6311},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Diagnosis and management of eosinophilic esophagitis in children: An update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN).\n \n \n \n \n\n\n \n Amil-Dias, J.; Oliva, S.; Papadopoulou, A.; Thomson, M.; Gutiérrez-Junquera, C.; Kalach, N.; Orel, R.; Auth, M. K.; Nijenhuis-Hendriks, D.; Strisciuglio, C.; Bauraind, O.; Chong, S.; Ortega, G. D.; Férnandez, S. F.; Furman, M.; Garcia-Puig, R.; Gottrand, F.; Homan, M.; Huysentruyt, K.; Kostovski, A.; Otte, S.; Rea, F.; Roma, E.; Romano, C.; Tzivinikos, C.; Urbonas, V.; Velde, S. V.; Zangen, T.; and Zevit, N.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 79(2): 394–437. August 2024.\n \n\n\n\n
\n\n\n\n \n \n $\"Diagnosis$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{amil-dias_diagnosis_2024,\n\ttitle = {Diagnosis and management of eosinophilic esophagitis in children: {An} update from the {European} {Society} for {Paediatric} {Gastroenterology}, {Hepatology} and {Nutrition} ({ESPGHAN})},\n\tvolume = {79},\n\tissn = {1536-4801},\n\tshorttitle = {Diagnosis and management of eosinophilic esophagitis in children},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/38923067/},\n\tdoi = {10.1002/jpn3.12188},\n\tabstract = {INTRODUCTION: Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus characterized by symptoms of esophageal dysfunction and histologically by predominantly eosinophilic infiltration of the squamous epithelium. European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) published a guideline in 2014; however, the rapid evolution of knowledge about pathophysiology, diagnostic criteria, and therapeutic options have made an update necessary.\nMETHODS: A consensus group of pediatric gastroenterologists from the ESPGHAN Working Group on Eosinophilic Gastrointestinal Diseases (ESPGHAN EGID WG) reviewed the recent literature and proposed statements and recommendations on 28 relevant questions about EoE. A comprehensive electronic literature search was performed in MEDLINE, EMBASE, and Cochrane databases from 2014 to 2022. The Grading of Recommendations Assessment, Development and Evaluation system was used to assess the quality of evidence and formulate recommendations.\nRESULTS: A total of 52 statements based on the available evidence and 44 consensus-based recommendations are available. A revision of the diagnostic protocol, options for initial drug treatment, and the new concept of simplified empiric elimination diets are now available. Biologics are becoming a part of the potential armamentarium for refractory EoE, and systemic steroids may be considered as the initial treatment for esophageal strictures before esophageal dilation. The importance and assessment of quality of life and a planned transition to adult medical care are new areas addressed in this guideline.\nCONCLUSION: Research in recent years has led to a better understanding of childhood EoE. This guideline incorporates the new findings and provides a practical guide for clinicians treating children diagnosed with EoE.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Amil-Dias, Jorge and Oliva, Salvatore and Papadopoulou, Alexandra and Thomson, Mike and Gutiérrez-Junquera, Carolina and Kalach, Nicolas and Orel, Rok and Auth, Marcus Karl-Heinz and Nijenhuis-Hendriks, Danielle and Strisciuglio, Caterina and Bauraind, Olivia and Chong, Sonny and Ortega, Gloria Dominguez and Férnandez, Sonia Férnandez and Furman, Mark and Garcia-Puig, Roger and Gottrand, Frederic and Homan, Matjaz and Huysentruyt, Koen and Kostovski, Aco and Otte, Sebastian and Rea, Francesca and Roma, Eleftheria and Romano, Claudio and Tzivinikos, Christos and Urbonas, Vaidotas and Velde, Saskia Vande and Zangen, Tsili and Zevit, Noam},\n\tmonth = aug,\n\tyear = {2024},\n\tpmid = {38923067},\n\tkeywords = {Child, Eosinophilic Esophagitis, Europe, Gastroenterology, Humans, Societies, Medical, biopsies, endoscopy, eosinophilic esophagitis, food sensitivity, histology},\n\tpages = {394--437},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n The French Experience with a Population-Based Esophageal Atresia Registry (RENATO).\n \n \n \n \n\n\n \n Sfeir, R.; Aumar, M.; Sharma, D.; Labreuche, J.; Dauchet, L.; and Gottrand, F.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 34(2): 137–142. April 2024.\n \n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{sfeir_french_2024,\n\ttitle = {The {French} {Experience} with a {Population}-{Based} {Esophageal} {Atresia} {Registry} ({RENATO})},\n\tvolume = {34},\n\tissn = {1439-359X},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/37940126/},\n\tdoi = {10.1055/a-2206-6837},\n\tabstract = {This paper presented a national register for esophageal atresia (EA) started in January 2008. We report our experience about the conception of this database and its coordination. Data management and data quality are also detailed. In 2023, more than 2,500 patients with EA are included. Prevalence of EA in France was calculated at 1.8/10,000 live birth. Main clinical results are listed with scientific publications issued directly from the register.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Sfeir, Rony and Aumar, Madeleine and Sharma, Dyuti and Labreuche, Julien and Dauchet, Luc and Gottrand, Frederic},\n\tmonth = apr,\n\tyear = {2024},\n\tpmid = {37940126},\n\tkeywords = {Data Management, Esophageal Atresia, France, Humans, Prevalence, Registries, Tracheoesophageal Fistula},\n\tpages = {137--142},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n An International Collaborative Initiative to Establish a Quality-of-Life Questionnaire for Children and Adolescents with Repair of Esophageal Atresia in 14 Countries.\n \n \n \n \n\n\n \n The International Ea-Qol Group, n.\n\n\n \n\n\n\n Children (Basel, Switzerland), 11(3): 286. February 2024.\n \n\n\n\n
\n\n\n\n \n \n $\"An$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{the_international_ea-qol_group_international_2024,\n\ttitle = {An {International} {Collaborative} {Initiative} to {Establish} a {Quality}-of-{Life} {Questionnaire} for {Children} and {Adolescents} with {Repair} of {Esophageal} {Atresia} in 14 {Countries}},\n\tvolume = {11},\n\tissn = {2227-9067},\n\turl = {http://hdl.handle.net/20.500.12210/114129},\n\tdoi = {10.3390/children11030286},\n\tabstract = {The EA-QOL questionnaire measures quality-of-life specifically for children born with esophageal atresia (EA) aged 8-18 and was completed in Sweden and Germany. This study aimed to describe an international collaborative initiative to establish a semantically equivalent linguistic version of the EA-QOL questionnaires in 12 new countries. The 24-item EA-QOL questionnaire was translated into the target languages and the translated questionnaire was evaluated through cognitive debriefing interviews with children with EA aged 8-18 and their parents in each new country. Participants rated an item as to whether an item was easy to understand and sensitive/uncomfortable to answer. They could choose not to reply to a non-applicable/problematic item and provide open comments. Data were analyzed using predefined psychometric criteria; item clarity ≥80\\%, item sensitive/uncomfortable to answer ≤20\\%, item feasibility(missing item responses ≤5\\%). Decision to improve any translation was made by native experts-patient stakeholders and the instrument developer. Like in Sweden and Germany, all items in the cross-cultural analysis of child self-report (ntot = 82, 4-10 children/country) met the criteria for item clarity in all 12 new countries, and in parent-report (ntot = 86, 5-10 parents/country) in 8/12 countries. All items fulfilled the criteria for sensitive/uncomfortable to answer (child-report 1.2-9.9\\%; parent-report 0-11.6\\%) and item feasibility. Poor translations were resolved. Hence, this study has established semantically equivalent linguistic versions of the EA-QOL questionnaire for use in children aged 8-18 with repair of EA in and across 14 countries.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Children (Basel, Switzerland)},\n\tauthor = {The International Ea-Qol Group, null},\n\tmonth = feb,\n\tyear = {2024},\n\tpmid = {38539321},\n\tpmcid = {PMC10968779},\n\tkeywords = {children, cognitive debriefing interview, cultural adaptation, esophageal atresia, quality of life, rare disease},\n\tpages = {286},\n}\n\n\n\n

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\n \n 2023\n \n \n (10)\n \n \n

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\n \n\n \n \n \n \n \n \n The International Network on Oesophageal Atresia (INoEA) consensus guidelines on the transition of patients with oesophageal atresia-tracheoesophageal fistula.\n \n \n \n \n\n\n \n Krishnan, U.; Dumont, M. W.; Slater, H.; Gold, B. D.; Seguy, D.; Bouin, M.; Wijnen, R.; Dall'Oglio, L.; Costantini, M.; Koumbourlis, A. C.; Kovesi, T. A.; Rutter, M. J.; Soma, M.; Menzies, J.; Van Malleghem, A.; Rommel, N.; Dellenmark-Blom, M.; Wallace, V.; Culnane, E.; Slater, G.; Gottrand, F.; and Faure, C.\n\n\n \n\n\n\n Nature Reviews. Gastroenterology & Hepatology, 20(11): 735–755. November 2023.\n \n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{krishnan_international_2023,\n\ttitle = {The {International} {Network} on {Oesophageal} {Atresia} ({INoEA}) consensus guidelines on the transition of patients with oesophageal atresia-tracheoesophageal fistula},\n\tvolume = {20},\n\tissn = {1759-5053},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/37286639/},\n\tdoi = {10.1038/s41575-023-00789-w},\n\tabstract = {Oesophageal atresia-tracheoesophageal fistula (EA-TEF) is a common congenital digestive disease. Patients with EA-TEF face gastrointestinal, surgical, respiratory, otolaryngological, nutritional, psychological and quality of life issues in childhood, adolescence and adulthood. Although consensus guidelines exist for the management of gastrointestinal, nutritional, surgical and respiratory problems in childhood, a systematic approach to the care of these patients in adolescence, during transition to adulthood and in adulthood is currently lacking. The Transition Working Group of the International Network on Oesophageal Atresia (INoEA) was charged with the task of developing uniform evidence-based guidelines for the management of complications through the transition from adolescence into adulthood. Forty-two questions addressing the diagnosis, treatment and prognosis of gastrointestinal, surgical, respiratory, otolaryngological, nutritional, psychological and quality of life complications that patients with EA-TEF face during adolescence and after the transition to adulthood were formulated. A systematic literature search was performed based on which recommendations were made. All recommendations were discussed and finalized during consensus meetings, and the group members voted on each recommendation. Expert opinion was used when no randomized controlled trials were available to support the recommendation. The list of the 42 statements, all based on expert opinion, was voted on and agreed upon.},\n\tlanguage = {eng},\n\tnumber = {11},\n\tjournal = {Nature Reviews. Gastroenterology \\& Hepatology},\n\tauthor = {Krishnan, Usha and Dumont, Michael W. and Slater, Hayley and Gold, Benjamin D. and Seguy, David and Bouin, Mikael and Wijnen, Rene and Dall'Oglio, Luigi and Costantini, Mario and Koumbourlis, Anastassios C. and Kovesi, Thomas A. and Rutter, Michael J. and Soma, Marlene and Menzies, Jessica and Van Malleghem, Audrey and Rommel, Nathalie and Dellenmark-Blom, Michaela and Wallace, Vuokko and Culnane, Evelyn and Slater, Graham and Gottrand, Frederic and Faure, Christophe},\n\tmonth = nov,\n\tyear = {2023},\n\tpmid = {37286639},\n\tkeywords = {Esophageal Atresia, Gastrointestinal Diseases, Humans, Quality of Life, Tracheoesophageal Fistula},\n\tpages = {735--755},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Prophylactic Acid-suppression Medication to Prevent Anastomotic Strictures After Oesophageal Atresia Surgery: A Systematic Review and Meta-analysis.\n \n \n \n\n\n \n Wyllie, T.; Folaranmi, E.; Sekaran, P.; Watkins, W. J.; and Chakraborty, M.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 58(10): 1954–1962. October 2023.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{wyllie_prophylactic_2023,\n\ttitle = {Prophylactic {Acid}-suppression {Medication} to {Prevent} {Anastomotic} {Strictures} {After} {Oesophageal} {Atresia} {Surgery}: {A} {Systematic} {Review} and {Meta}-analysis},\n\tvolume = {58},\n\tissn = {1531-5037},\n\tshorttitle = {Prophylactic {Acid}-suppression {Medication} to {Prevent} {Anastomotic} {Strictures} {After} {Oesophageal} {Atresia} {Surgery}},\n\tdoi = {10.1016/j.jpedsurg.2023.05.024},\n\tabstract = {BACKGROUND: Anastomotic stricture is a common postoperative complication of oesophageal atresia ± tracheoesophageal fistula (OA/TOF) repair. Acid gastro-oesophageal reflux disease (GORD) is considered to be a factor in stricture formation and acid suppression medication is recommended post-operatively in consensus guidance. We aimed to investigate whether patients who were treated prophylactically with acid suppression medication had a reduced incidence of strictures compared to those who did not receive it.\nMETHODS: A systematic review of studies was performed, searching multiple databases without language or date restrictions. Multiple reviewers independently assessed study eligibility and literature quality. The primary outcome was anastomotic stricture formation, with secondary outcomes of GORD, anastomotic leak, and oesophagitis. Meta-analysis was performed using a random effects model, and the results were expressed as an odds ratio (OR) with 95\\% confidence intervals (CI).\nRESULTS: No randomised studies on the topic were identified. Twelve observational studies were included in the analysis with ten reporting the primary outcome. The quality assessment showed a high risk of bias in several papers, predominantly due to non-objective methods of assessment of oesophageal stricture and the non-prospective, non-randomised nature of the studies. Overall, 1395 patients were evaluated, of which 753 received acid suppression medication. Meta-analysis revealed a trend towards increased odds of anastomotic strictures in infants receiving prophylactic medication, but this was not statistically significant (OR 1.33; 95\\% CI 0.92, 1.92). No significant differences were found in secondary outcomes.\nCONCLUSIONS: This meta-analysis found no evidence of a statistically significant link between the prophylactic prescribing of acid suppression medication and the risk of developing anastomotic stricture after OA repair. The literature in this area is limited to observational studies and a randomised controlled trial is recommended to explore this question.\nLEVEL OF EVIDENCE: Level III.},\n\tlanguage = {eng},\n\tnumber = {10},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Wyllie, Thomas and Folaranmi, Eniola and Sekaran, Prabhu and Watkins, W. John and Chakraborty, Mallinath},\n\tmonth = oct,\n\tyear = {2023},\n\tpmid = {37355433},\n\tkeywords = {Acid suppression, Anastomosis, Anastomosis, Surgical, Constriction, Pathologic, Esophageal Atresia, Esophageal Stenosis, Esophageal atresia, Gastroesophageal Reflux, H2-blockers, Humans, Infant, Observational Studies as Topic, PPI, Postoperative Complications, Randomized Controlled Trials as Topic, Stricture, Tracheo-esophageal fistula, Tracheoesophageal Fistula},\n\tpages = {1954--1962},\n}\n\n\n\n\n\n\n\n

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\n BACKGROUND: Anastomotic stricture is a common postoperative complication of oesophageal atresia ± tracheoesophageal fistula (OA/TOF) repair. Acid gastro-oesophageal reflux disease (GORD) is considered to be a factor in stricture formation and acid suppression medication is recommended post-operatively in consensus guidance. We aimed to investigate whether patients who were treated prophylactically with acid suppression medication had a reduced incidence of strictures compared to those who did not receive it. METHODS: A systematic review of studies was performed, searching multiple databases without language or date restrictions. Multiple reviewers independently assessed study eligibility and literature quality. The primary outcome was anastomotic stricture formation, with secondary outcomes of GORD, anastomotic leak, and oesophagitis. Meta-analysis was performed using a random effects model, and the results were expressed as an odds ratio (OR) with 95% confidence intervals (CI). RESULTS: No randomised studies on the topic were identified. Twelve observational studies were included in the analysis with ten reporting the primary outcome. The quality assessment showed a high risk of bias in several papers, predominantly due to non-objective methods of assessment of oesophageal stricture and the non-prospective, non-randomised nature of the studies. Overall, 1395 patients were evaluated, of which 753 received acid suppression medication. Meta-analysis revealed a trend towards increased odds of anastomotic strictures in infants receiving prophylactic medication, but this was not statistically significant (OR 1.33; 95% CI 0.92, 1.92). No significant differences were found in secondary outcomes. CONCLUSIONS: This meta-analysis found no evidence of a statistically significant link between the prophylactic prescribing of acid suppression medication and the risk of developing anastomotic stricture after OA repair. The literature in this area is limited to observational studies and a randomised controlled trial is recommended to explore this question. LEVEL OF EVIDENCE: Level III.\n

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\n \n\n \n \n \n \n \n Respiratory physiology during NAVA ventilation in neonates born with a congenital diaphragmatic hernia: The \"NAVA-diaph\" pilot study.\n \n \n \n\n\n \n Dreyfus, L.; Butin, M.; Plaisant, F.; Claris, O.; and Baudin, F.\n\n\n \n\n\n\n Pediatric Pulmonology, 58(5): 1542–1550. May 2023.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{dreyfus_respiratory_2023,\n\ttitle = {Respiratory physiology during {NAVA} ventilation in neonates born with a congenital diaphragmatic hernia: {The} "{NAVA}-diaph" pilot study},\n\tvolume = {58},\n\tissn = {1099-0496},\n\tshorttitle = {Respiratory physiology during {NAVA} ventilation in neonates born with a congenital diaphragmatic hernia},\n\tdoi = {10.1002/ppul.26357},\n\tabstract = {BACKGROUND: Neurally adjusted ventilatory assist (NAVA) is a ventilatory mode that delivers synchronized ventilation, proportional to the electrical activity of the diaphragm (EAdi). Although it has been proposed in infants with a congenital diaphragmatic hernia (CDH), the diaphragmatic defect and the surgical repair could alter the physiology of the diaphragm.\nAIM: To evaluate, in a pilot study, the relationship between the respiratory drive (EAdi) and the respiratory effort in neonates with CDH during the postsurgical period under either NAVA ventilation or conventional ventilation (CV).\nMETHODS: This prospective physiological study included eight neonates admitted to a neonatal intensive care unit with a diagnosis of CDH. EAdi, esophageal, gastric, and transdiaphragmatic pressure, as well as clinical parameters, were recorded during NAVA and CV (synchronized intermittent mandatory pressure ventilation) in the postsurgical period.\nRESULTS: EAdi was detectable and there was a correlation between the ΔEAdi (maximal - minimal values) and the transdiaphragmatic pressure (r = 0.26, 95\\% confidence interval [CI] [0.222; 0.299]). There was no significant difference in terms of clinical or physiological parameters during NAVA compared to CV, including work of breathing.\nCONCLUSION: Respiratory drive and effort were correlated in infants with CDH and therefore NAVA is a suitable proportional mode in this population. EAdi can also be used to monitor the diaphragm for individualized support.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Pediatric Pulmonology},\n\tauthor = {Dreyfus, Lélia and Butin, Marine and Plaisant, Frank and Claris, Olivier and Baudin, Florent},\n\tmonth = may,\n\tyear = {2023},\n\tpmid = {36807570},\n\tkeywords = {Diaphragm, Hernias, Diaphragmatic, Congenital, Humans, Infant, Infant, Newborn, Interactive Ventilatory Support, NAVA ventilation, Pilot Projects, Prospective Studies, Respiration, Artificial, Respiratory Rate, congenital diaphragmatic hernia, respiratory physiology, transpulmonary pressure, work of breathing},\n\tpages = {1542--1550},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Complications of one-step button percutaneous endoscopic gastrostomy in children.\n \n \n \n \n\n\n \n Jean-Bart C, C.; Aumar, M.; Ley, D.; Antoine, M.; Cailliau, E.; Coopman, S.; Guimber, D.; Ganga, S.; Turck, D.; and Gottrand, F.\n\n\n \n\n\n\n European Journal of Pediatrics, 182(4): 1665–1672. April 2023.\n \n\n\n\n
\n\n\n\n \n \n $\"Complications$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{jean-bart_c_complications_2023,\n\ttitle = {Complications of one-step button percutaneous endoscopic gastrostomy in children},\n\tvolume = {182},\n\tissn = {1432-1076},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/36735060/},\n\tdoi = {10.1007/s00431-023-04822-7},\n\tabstract = {To assess the complications of one-step button percutaneous endoscopic gastrostomy (B-PEG) and determine risk factors for developing stomal infections or gastropexy complications. A retrospective study of 679 children who underwent a B-PEG procedure in a single tertiary care center over a 10-year period to December 2020 was conducted. Patient characteristics, early complications (occurring ≤ 7 days after the procedure), late complications ({\\textgreater} 7 days after the procedure), and outcomes were collected from medical records. A list of potential risk factors, including age at procedure, prematurity, underlying neurological disease, and undernutrition, was determined a priori. At least 1 year of follow-up was available for 513 patients. Median follow-up duration was 2.8 years (interquartile range 1.0-4.9 years). Major complications were rare ({\\textless} 2\\%), and no death was related to B-PEG. Early complications affected 15.9\\% of the study population, and 78.0\\% of children presented late complications. Development of granulation tissue was the most common complication followed in frequency by tube dislodgment and T-fastener complications. Only 24 patients (3.5\\%) presented stomal infections. Young age at the time of PEG placement (odds ratio (OR) 2.34 [1.03-5.30], p = .042) was a risk factor for developing peristomal infection. T-fastener migration occurred in 17.3\\% of children, and we found underlying neurological disease was a protective factor (OR 0.59 [0.37-0.92], p = .019).  Conclusion: B-PEG is a safe method and associated with a low rate of local infection. However, T-fasteners are associated with significant morbidity and require particular attention in young and premature infants. What is Known: • Percutaneous endoscopic gastrostomy (PEG) is the preferred method to provide long-term enteral nutrition in children to prevent malnutrition. The Pull-PEG method is still the most commonly used with complications , such as stomal infection. Since its description, only a few studies have reported postoperative complications of one-step button PEG (B-PEG). What is New: • T-fastener complications were not rare, and underlying neurologic disease was a protective factor. A very low rate of stomal infection was described, and young age at the time of PEG placement was a risk factor. The B-PEG is a safe method with fewer major complications than P-PEG in children.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {European Journal of Pediatrics},\n\tauthor = {Jean-Bart C, Charlotte and Aumar, Madeleine and Ley, Delphine and Antoine, Matthieu and Cailliau, Emeline and Coopman, Stéphanie and Guimber, Dominique and Ganga, Serge and Turck, Dominique and Gottrand, Frédéric},\n\tmonth = apr,\n\tyear = {2023},\n\tpmid = {36735060},\n\tkeywords = {Child, Enteral Nutrition, Gastropexy, Gastrostomy, Humans, Infant, Malnutrition, Postoperative Complications, Pull technique, Push technique, Retrospective Studies, Risk Factors, Stomal infection, T-bar},\n\tpages = {1665--1672},\n}\n\n\n\n

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\n To assess the complications of one-step button percutaneous endoscopic gastrostomy (B-PEG) and determine risk factors for developing stomal infections or gastropexy complications. A retrospective study of 679 children who underwent a B-PEG procedure in a single tertiary care center over a 10-year period to December 2020 was conducted. Patient characteristics, early complications (occurring ≤ 7 days after the procedure), late complications (\\textgreater 7 days after the procedure), and outcomes were collected from medical records. A list of potential risk factors, including age at procedure, prematurity, underlying neurological disease, and undernutrition, was determined a priori. At least 1 year of follow-up was available for 513 patients. Median follow-up duration was 2.8 years (interquartile range 1.0-4.9 years). Major complications were rare (\\textless 2%), and no death was related to B-PEG. Early complications affected 15.9% of the study population, and 78.0% of children presented late complications. Development of granulation tissue was the most common complication followed in frequency by tube dislodgment and T-fastener complications. Only 24 patients (3.5%) presented stomal infections. Young age at the time of PEG placement (odds ratio (OR) 2.34 [1.03-5.30], p = .042) was a risk factor for developing peristomal infection. T-fastener migration occurred in 17.3% of children, and we found underlying neurological disease was a protective factor (OR 0.59 [0.37-0.92], p = .019). Conclusion: B-PEG is a safe method and associated with a low rate of local infection. However, T-fasteners are associated with significant morbidity and require particular attention in young and premature infants. What is Known: • Percutaneous endoscopic gastrostomy (PEG) is the preferred method to provide long-term enteral nutrition in children to prevent malnutrition. The Pull-PEG method is still the most commonly used with complications , such as stomal infection. Since its description, only a few studies have reported postoperative complications of one-step button PEG (B-PEG). What is New: • T-fastener complications were not rare, and underlying neurologic disease was a protective factor. A very low rate of stomal infection was described, and young age at the time of PEG placement was a risk factor. The B-PEG is a safe method with fewer major complications than P-PEG in children.\n

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\n \n\n \n \n \n \n \n \n Outcome of long gap esophageal atresia at 6 years: A prospective case control cohort study.\n \n \n \n \n\n\n \n Bourg, A.; Gottrand, F.; Parmentier, B.; Thomas, J.; Lehn, A.; Piolat, C.; Bonnard, A.; Sfeir, R.; Lienard, J.; Rousseau, V.; Pouzac, M.; Liard, A.; Buisson, P.; Haffreingue, A.; David, L.; Branchereau, S.; Carcauzon, V.; Kalfa, N.; Leclair, M.; Lardy, H.; Irtan, S.; Varlet, F.; Gelas, T.; Potop, D.; and Auger-Hunault, M.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 58(4): 747–755. April 2023.\n \n\n\n\n
\n\n\n\n \n \n $\"Outcome$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{bourg_outcome_2023,\n\ttitle = {Outcome of long gap esophageal atresia at 6 years: {A} prospective case control cohort study},\n\tvolume = {58},\n\tissn = {1531-5037},\n\tshorttitle = {Outcome of long gap esophageal atresia at 6 years},\n\turl = {http://hdl.handle.net/20.500.12210/79268},\n\tdoi = {10.1016/j.jpedsurg.2022.07.023},\n\tabstract = {BACKGROUND DATA: EA is the most frequent congenital esophageal malformation. Long gap EA remains a therapeutic challenge for pediatric surgeons. A case case-control prospective study from a multi-institutional national French data base was performed to assess the outcome, at age of 1 and 6 years, of long gap esophageal atresia (EA) compared with non-long gap EA/tracheo-esophageal fistula (TEF). The secondary aim was to assess whether initial treatment (delayed primary anastomosis of native esophagus vs. esophageal replacement) influenced mortality and morbidity at ages 1 and 6 years.\nMETHODS: A multicentric population-based prospective study was performed and included all patients who underwent EA surgery in France from January 1, 2008 to December 31, 2010. A comparative study was performed with non-long gap EA/TEF patients. Morbidity at birth, 1 year, and 6 years was assessed.\nRESULTS: Thirty-one patients with long gap EA were compared with 62 non-long gap EA/TEF patients. At age 1 year, the long gap EA group had longer parenteral nutrition support and longer hospital stay and were significantly more likely to have complications both early post-operatively and before age 1 year compared with the non-long gap EA/TEF group. At 6 years, digestive complications were more frequent in long gap compared to non-long gap EA/TEF patients. Tracheomalacia was the only respiratory complication that differed between the groups. Spine deformation was less frequent in the long gap group. There were no differences between conservative and replacement groups at ages 1 and 6 years except feeding difficulties that were more common in the native esophagus group.\nCONCLUSIONS: Long gap strongly influenced digestive morbidity at age 6 years.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Bourg, Agate and Gottrand, Frédéric and Parmentier, Benoit and Thomas, Julie and Lehn, Anne and Piolat, Christian and Bonnard, Arnaud and Sfeir, Rony and Lienard, Julie and Rousseau, Véronique and Pouzac, Myriam and Liard, Agnès and Buisson, Philippe and Haffreingue, Aurore and David, Louis and Branchereau, Sophie and Carcauzon, Véronique and Kalfa, Nicolas and Leclair, Marc-David and Lardy, Hubert and Irtan, Sabine and Varlet, François and Gelas, Thomas and Potop, Diana and Auger-Hunault, Marie},\n\tmonth = apr,\n\tyear = {2023},\n\tpmid = {35970676},\n\tkeywords = {Case-Control Studies, Child, Child, Preschool, Complications, Dysphagia, Esophageal Atresia, Esophageal atresia, Esophageal replacement, Gastro-esophageal reflux disease, Humans, Infant, Infant, Newborn, Long gap esophageal atresia, Midterm outcomes, Prospective Studies, Retrospective Studies, Tracheoesophageal Fistula, Treatment Outcome},\n\tpages = {747--755},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Establishment of a condition-specific quality-of-life questionnaire for children born with esophageal atresia aged 2-7 across 14 countries.\n \n \n \n \n\n\n \n International EA-QOL Group\n\n\n \n\n\n\n Frontiers in Pediatrics, 11: 1253892. 2023.\n \n\n\n\n
\n\n\n\n \n \n $\"Establishment$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{international_ea-qol_group_establishment_2023,\n\ttitle = {Establishment of a condition-specific quality-of-life questionnaire for children born with esophageal atresia aged 2-7 across 14 countries},\n\tvolume = {11},\n\tissn = {2296-2360},\n\turl = {https://lilloa.univ-lille.fr/handle/20.500.12210/91130},\n\tdoi = {10.3389/fped.2023.1253892},\n\tabstract = {BACKGROUND: Esophageal atresia (EA) is a rare congenital anomaly characterized by a discontinuity of the esophagus. Following surgical repair, survival rates have improved dramatically the past decenniums and today exceed 90\\%, but the children commonly present with esophageal and respiratory morbidity. In 2018, a condition-specific quality-of-life questionnaire for children with esophageal atresia (EA) aged 2-7 in Sweden-Germany was finalized (The EA-QOL questionnaire). The study aim was to describe the evaluation of the new translations across 12 new countries in Europe, Asia, Africa, Central-and North America.\nMETHODS: Following forward-backward translation into the new languages, the 17-item EA-QOL questionnaire was tested in cognitive debriefing interviews with parents of children with EA aged 2-7. Parents rated if each item was easy to understand (clarity) and sensitive to answer (interference with personal integrity). They could skip responding to a non-applicable/problematic item and give open comments. Predefined psychometric criteria were used; item clarity ≥80\\%/item sensitive to answer ≤20\\%/item feasibility ≤5\\% missing item responses. The decision to modify the translation was based on native expert, patient stakeholder, and instrument developer review, and the need for harmonization between translations.\nRESULTS: Similar to findings in the Swedish-German cognitive debriefing, the cross-cultural analysis of input from 116 parents from 12 new countries (4-14 parents, median 9 parents/country) showed that all items in the EA-QOL questionnaire fulfilled the criteria for item clarity ≥80\\% and sensitive to answer (ranging from 1\\%-4.5\\%), although results varied between countries. Four items had missing responses between 5.2\\% and 13.4\\%, three within the same domain and were in line with parents' explanations. Poor translations and feasibility were improved.\nCONCLUSIONS: Based on parent input, the collaboration between native experts, patient stakeholders, and instrument developers, a linguistic version of the EA-QOL questionnaire for children aged 2-7 for use in and across 14 countries has been established. These efforts have set the conditions for a cross-cultural field test of the EA-QOL questionnaire and will open the doors for a new chapter in outcome research, registries, and clinical practice concerning children with EA. In the long-term, this will help increase knowledge of the disease's burden, promote patient-centeredness, exchange of information between nations, and strengthen evidence-based treatments for children born with EA.},\n\tlanguage = {eng},\n\tjournal = {Frontiers in Pediatrics},\n\tauthor = {{International EA-QOL Group}},\n\tyear = {2023},\n\tpmid = {37936889},\n\tpmcid = {PMC10626467},\n\tkeywords = {children, cognitive debriefing, esophageal atresia, quality of life, rare disease, translation, validity},\n\tpages = {1253892},\n}\n\n\n\n

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\n BACKGROUND: Esophageal atresia (EA) is a rare congenital anomaly characterized by a discontinuity of the esophagus. Following surgical repair, survival rates have improved dramatically the past decenniums and today exceed 90%, but the children commonly present with esophageal and respiratory morbidity. In 2018, a condition-specific quality-of-life questionnaire for children with esophageal atresia (EA) aged 2-7 in Sweden-Germany was finalized (The EA-QOL questionnaire). The study aim was to describe the evaluation of the new translations across 12 new countries in Europe, Asia, Africa, Central-and North America. METHODS: Following forward-backward translation into the new languages, the 17-item EA-QOL questionnaire was tested in cognitive debriefing interviews with parents of children with EA aged 2-7. Parents rated if each item was easy to understand (clarity) and sensitive to answer (interference with personal integrity). They could skip responding to a non-applicable/problematic item and give open comments. Predefined psychometric criteria were used; item clarity ≥80%/item sensitive to answer ≤20%/item feasibility ≤5% missing item responses. The decision to modify the translation was based on native expert, patient stakeholder, and instrument developer review, and the need for harmonization between translations. RESULTS: Similar to findings in the Swedish-German cognitive debriefing, the cross-cultural analysis of input from 116 parents from 12 new countries (4-14 parents, median 9 parents/country) showed that all items in the EA-QOL questionnaire fulfilled the criteria for item clarity ≥80% and sensitive to answer (ranging from 1%-4.5%), although results varied between countries. Four items had missing responses between 5.2% and 13.4%, three within the same domain and were in line with parents' explanations. Poor translations and feasibility were improved. CONCLUSIONS: Based on parent input, the collaboration between native experts, patient stakeholders, and instrument developers, a linguistic version of the EA-QOL questionnaire for children aged 2-7 for use in and across 14 countries has been established. These efforts have set the conditions for a cross-cultural field test of the EA-QOL questionnaire and will open the doors for a new chapter in outcome research, registries, and clinical practice concerning children with EA. In the long-term, this will help increase knowledge of the disease's burden, promote patient-centeredness, exchange of information between nations, and strengthen evidence-based treatments for children born with EA.\n

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\n \n\n \n \n \n \n \n \n Endoscopic management of esophageal mucosal bridges in children with esophageal atresia.\n \n \n \n \n\n\n \n Antoine, M.; Krishnan, U.; Manfredi, M.; Cervinskiene, J.; Viala, J.; Brendel, J.; Tzivinikos, C.; Vanrenterghem, A.; Dimitrov, G.; Hauser, B.; Laverdure, N.; Rohmer, B.; Behal, H.; Nicolas, A.; and Gottrand, F.\n\n\n \n\n\n\n Surgical Endoscopy, 37(12): 9167–9172. December 2023.\n \n\n\n\n
\n\n\n\n \n \n $\"Endoscopic$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{antoine_endoscopic_2023,\n\ttitle = {Endoscopic management of esophageal mucosal bridges in children with esophageal atresia},\n\tvolume = {37},\n\tissn = {1432-2218},\n\turl = {http://hdl.handle.net/20.500.12210/88775},\n\tdoi = {10.1007/s00464-023-10492-1},\n\tabstract = {BACKGROUND AND STUDY AIMS: Esophageal mucosal bridge (EMB) may be diagnosed at the anastomotic site in children operated on for esophageal atresia (EA) but so far only a few cases (n = 4) have been reported. This study aimed to characterize EMB in children with EA, risk factors, and treatment.\nPATIENTS AND METHODS: This retrospective multicenter study recorded patient's characteristics, EMB diagnosis circumstances, endoscopic management, follow-up, and EMB recurrence in children with EA aged less than 18 years, compared with paired EA patients without EMB.\nRESULTS: Thirty patients were included (60\\% male, 90\\% EA/tracheoesophageal fistula, 43\\% associated malformations). Compared to 44 paired controls, EMB was associated with a history of nasogastric tube feeding (31\\% vs. 9.1\\%, p = 0.02) and severe gastroesophageal reflux disease (history of fundoplication: 41.4\\% vs. 13.6\\%, p {\\textless} 0.01). 77\\% had symptoms (food impaction and/or dysphagia). Endoscopic management was performed in 53\\% of patients (83\\% electrocoagulation) with no technical difficulties or complications. 80\\% of the symptomatic patients with EMB improved after endoscopic treatment, independently of anastomotic stricture dilatation or not.\nCONCLUSION: EMB endoscopic management by electrocoagulation is safe and often leads to symptom improvement.},\n\tlanguage = {eng},\n\tnumber = {12},\n\tjournal = {Surgical Endoscopy},\n\tauthor = {Antoine, Matthieu and Krishnan, Usha and Manfredi, Michael and Cervinskiene, Julija and Viala, Jérôme and Brendel, Julia and Tzivinikos, Christos and Vanrenterghem, Audrey and Dimitrov, Georges and Hauser, Bruno and Laverdure, Noémie and Rohmer, Barbara and Behal, Hélène and Nicolas, Audrey and Gottrand, Frédéric},\n\tmonth = dec,\n\tyear = {2023},\n\tpmid = {37831175},\n\tpmcid = {PMC10709217},\n\tkeywords = {Child, Deglutition Disorders, Endoscopy, Esophageal Atresia, Esophageal Stenosis, Esophageal atresia, Esophageal mucosal bridge, Female, Fundoplication, Humans, Male, Pediatric gastrointestinal endoscopy, Postoperative Complications, Retrospective Studies, Tracheoesophageal Fistula, Treatment Outcome},\n\tpages = {9167--9172},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Combined esophageal and duodenal atresia: A review of the literature from 1950 to 2020.\n \n \n \n \n\n\n \n Doval, L.; Rousseau, V.; and Irtan, S.\n\n\n \n\n\n\n Archives De Pediatrie: Organe Officiel De La Societe Francaise De Pediatrie, 30(6): 420–426. August 2023.\n \n\n\n\n
\n\n\n\n \n \n $\"Combined$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{doval_combined_2023,\n\ttitle = {Combined esophageal and duodenal atresia: {A} review of the literature from 1950 to 2020},\n\tvolume = {30},\n\tissn = {1769-664X},\n\tshorttitle = {Combined esophageal and duodenal atresia},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/37328325/},\n\tdoi = {10.1016/j.arcped.2023.05.004},\n\tabstract = {The combination of duodenal atresia (DA) and esophageal atresia (EA) is very rare. With improvements in prenatal sonography and the use of fetal magnetic resonance imaging (MRI), these malformations can be diagnosed in a more accurate and timely manner; polyhydramnios remains the most common sign despite having a low specificity. The high rate of associated anomalies (in 85\\% of cases) can also impact neonatal management and increase the morbidity rate; thus, it is of paramount importance to look for every possible associated malformation, such as VACTERL and chromosomic anomalies. The surgical management of this combination of atresias is not well defined and changes according to the patient's clinical status, the type of EA, and the other associated malformations. Management ranges from a primary approach for one of the atresias with delayed correction of the other (56.8\\%) to a simultaneous repair of both atresias (33.8\\%) with or without gastrostomy, or total abstention (9.4\\%). We suggest that a simultaneous approach can be safely performed on patients in good physical condition, with a birth weight over 1500 g, and with no major respiratory distress; this method begins by closing the tracheoesophageal fistula to protect the lung and then repairing the DA. The mortality rate has decreased over the years, dropping from 71\\% before 1980 to 24\\% after 2001. In this review, we present the available evidence on these conditions, focusing mostly on the epidemiology, prenatal diagnosis, neonatal management strategies, and outcome, with the aim of determining how the different clinical features and surgical approaches may impact on morbidity and mortality.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Archives De Pediatrie: Organe Officiel De La Societe Francaise De Pediatrie},\n\tauthor = {Doval, Lauren and Rousseau, Véronique and Irtan, Sabine},\n\tmonth = aug,\n\tyear = {2023},\n\tpmid = {37328325},\n\tkeywords = {Duodenal Obstruction, Duodenal atresia, Esophageal Atresia, Esophageal atresia, Female, Humans, Infant, Newborn, Pregnancy, Retrospective Studies, Tracheoesophageal Fistula},\n\tpages = {420--426},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Perioperative anaesthetic management and short-term outcome of neonatal repair of oesophageal atresia with or without tracheo-oesophageal fistula in Europe: A sub-analysis of the neonate and children audit of anaesthesia practice in Europe (NECTARINE) prospective multicenter observational study.\n \n \n \n \n\n\n \n van den Berg, J.; Johansen, M.; Disma, N.; Engelhardt, T.; Hansen, T. G.; Veyckemans, F.; Zielinska, M.; and de Graaff, J. C.\n\n\n \n\n\n\n European Journal of Anaesthesiology, 40(12): 936–945. December 2023.\n \n\n\n\n
\n\n\n\n \n \n $\"Perioperative$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{van_den_berg_perioperative_2023,\n\ttitle = {Perioperative anaesthetic management and short-term outcome of neonatal repair of oesophageal atresia with or without tracheo-oesophageal fistula in {Europe}: {A} sub-analysis of the neonate and children audit of anaesthesia practice in {Europe} ({NECTARINE}) prospective multicenter observational study},\n\tvolume = {40},\n\tissn = {1365-2346},\n\tshorttitle = {Perioperative anaesthetic management and short-term outcome of neonatal repair of oesophageal atresia with or without tracheo-oesophageal fistula in {Europe}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/37779460/},\n\tdoi = {10.1097/EJA.0000000000001905},\n\tabstract = {BACKGROUND: Oesophageal atresia with or without a tracheo-oesophageal fistula is a congenital abnormality that usually requires surgical repair within the first days of life.\nOBJECTIVE: Description of the perioperative anaesthetic management and outcomes of neonates undergoing surgery for oesophageal atresia with or without a tracheo-oesophageal fistula, included in the 'neonate and children audit of anaesthesia practice in Europe' (NECTARINE) database.\nDESIGN: Sub-analyses of prospective observational NECTARINE study.\nSETTING: European multicentre study.\nPATIENTS: Neonates who underwent surgery for oesophageal atresia with or without a tracheo-oesophageal fistula in the NECTARINE cohort were selected.\nMAIN OUTCOME MEASURES: Incidence rates with 95\\% confidence intervals were calculated for peri-operative clinical events which required a predetermined intervention, postoperative complications, and mortality.\nRESULTS: One hundred and three neonates undergoing a first surgical intervention for oesophageal atresia with or without a tracheo-oesophageal fistula repair were identified. Their median gestational age was 38 weeks with a median birth weight of 2840 [interquartile range 2150 to 3150] grams. Invasive monitoring was used in 66\\% of the procedures. The incidence of perioperative clinical events was 69\\% (95\\% confidence interval 59 to 77\\%), of 30-day postoperative complications 47\\% (95\\% confidence interval 38 to 57\\%) and the 30- and 90 days mortality rates were 2.1\\% and 2.6\\%, respectively.\nCONCLUSION: Oesophageal atresia with or without a tracheo-oesophageal fistula repair in neonates is associated with a high number of perioperative interventions in response to clinical events, a high incidence of postoperative complications, and a substantial mortality rate.},\n\tlanguage = {eng},\n\tnumber = {12},\n\tjournal = {European Journal of Anaesthesiology},\n\tauthor = {van den Berg, Johanneke and Johansen, Mathias and Disma, Nicola and Engelhardt, Thomas and Hansen, Tom Giedsing and Veyckemans, Francis and Zielinska, Marzena and de Graaff, Jurgen C.},\n\tmonth = dec,\n\tyear = {2023},\n\tpmid = {37779460},\n\tkeywords = {Anesthesia, Anesthetics, Esophageal Atresia, Humans, Infant, Infant, Newborn, Postoperative Complications, Prospective Studies, Tracheoesophageal Fistula},\n\tpages = {936--945},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Impact of diet on sensory processing in early childhood: summary of an interactive webconference / expert roundtable discussion.\n \n \n \n \n\n\n \n Lemale, J.; Lecoufle, A.; and Bellaiche, M.\n\n\n \n\n\n\n Postgraduate Medicine, 135(2): 87–92. March 2023.\n \n\n\n\n
\n\n\n\n \n \n $\"Impact$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{lemale_impact_2023,\n\ttitle = {Impact of diet on sensory processing in early childhood: summary of an interactive webconference / expert roundtable discussion},\n\tvolume = {135},\n\tissn = {1941-9260},\n\tshorttitle = {Impact of diet on sensory processing in early childhood},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/36408583/},\n\tdoi = {10.1080/00325481.2022.2147772},\n\tabstract = {Pediatric feeding disorders can be seen in up to 45\\% of normally developing children aged under 5 years old, mainly during the first three years of life when the child has inadequate food intake and/or difficulty maintaining adequate growth, and/or lack of age-appropriate eating habit. This article describes the opinion of a group of experts on children eating patterns and how to manage pediatric feeding disorders, with the aim to improve the quality of life of children and their caregivers.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Postgraduate Medicine},\n\tauthor = {Lemale, Julie and Lecoufle, Audrey and Bellaiche, Marc},\n\tmonth = mar,\n\tyear = {2023},\n\tpmid = {36408583},\n\tkeywords = {Child, Child, Preschool, Diet, Eating, Feeding Behavior, Humans, Perception, Quality of Life, Surveys and Questionnaires, early childhood, eating habits, feeding disorders, sensory processing},\n\tpages = {87--92},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Nutritional status at age 1 year in patients born with esophageal atresia: A population-based, prospective cohort study.\n \n \n \n \n\n\n \n Depoortere, S.; Lapillonne, A.; Sfeir, R.; Bonnard, A.; Gelas, T.; Panait, N.; Rabattu, P.; Guignot, A.; Lamireau, T.; Irtan, S.; Habonimana, E.; Breton, A.; Fouquet, V.; Allal, H.; Elbaz, F.; Talon, I.; Ranke, A.; Abely, M.; Michel, J.; Lirussi Borgnon, J.; Buisson, P.; Schmitt, F.; Lardy, H.; Petit, T.; Chaussy, Y.; Borderon, C.; Levard, G.; Cremillieux, C.; Tolg, C.; Breaud, J.; Jaby, O.; Grossos, C.; De Vries, P.; Arnould, M.; Pelatan, C.; Geiss, S.; Laplace, C.; Kyheng, M.; Nicolas, A.; Aumar, M.; and Gottrand, F.\n\n\n \n\n\n\n Frontiers in Pediatrics, 10: 969617. 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Nutritional$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{depoortere_nutritional_2022,\n\ttitle = {Nutritional status at age 1 year in patients born with esophageal atresia: {A} population-based, prospective cohort study},\n\tvolume = {10},\n\tissn = {2296-2360},\n\tshorttitle = {Nutritional status at age 1 year in patients born with esophageal atresia},\n\turl = {http://hdl.handle.net/20.500.12210/79192},\n\tdoi = {10.3389/fped.2022.969617},\n\tabstract = {OBJECTIVE: Despite recent progress in caring for patients born with esophageal atresia (EA), undernutrition and stunting remain common. Our study objective was to assess nutritional status in the first year after birth with EA and to identify factors associated with growth failure.\nSTUDY DESIGN: We conducted a population-based study of all infants born in France with EA between 2010 and 2016. Through the national EA register, we collected prenatal to 1 year follow-up data. We used body mass index and length-for-age ratio Z scores to define patients who were undernourished and stunted, respectively. Factors with P {\\textless} 0.20 in univariate analyses were retained in a logistic regression model.\nRESULTS: Among 1,154 patients born with EA, body mass index and length-for-age ratio Z scores at 1 year were available for about 61\\%. Among these, 15.2\\% were undernourished and 19\\% were stunted at the age of 1 year. There was no significant catch-up between ages 6 months and 1 year. Patients born preterm (41\\%), small for gestational age (17\\%), or with associated abnormalities (55\\%) were at higher risk of undernutrition and stunting at age 1 year (P {\\textless} 0.05). Neither EA type nor surgical treatment was associated with growth failure.\nCONCLUSION: Undernutrition and stunting are common during the first year after birth in patients born with EA. These outcomes are significantly influenced by early factors, regardless of EA type or surgical management. Identifying high-risk patient groups with EA (i.e., those born preterm, small for gestational age, and/or with associated abnormalities) may guide early nutritional support strategies.},\n\tlanguage = {eng},\n\tjournal = {Frontiers in Pediatrics},\n\tauthor = {Depoortere, Suzanne and Lapillonne, Alexandre and Sfeir, Rony and Bonnard, Arnaud and Gelas, Thomas and Panait, Nicoleta and Rabattu, Pierre-Yves and Guignot, Audrey and Lamireau, Thierry and Irtan, Sabine and Habonimana, Edouard and Breton, Anne and Fouquet, Virginie and Allal, Hossein and Elbaz, Frédéric and Talon, Isabelle and Ranke, Aline and Abely, Michel and Michel, Jean-Luc and Lirussi Borgnon, Joséphine and Buisson, Philippe and Schmitt, Françoise and Lardy, Hubert and Petit, Thierry and Chaussy, Yann and Borderon, Corinne and Levard, Guillaume and Cremillieux, Clara and Tolg, Cécilia and Breaud, Jean and Jaby, Olivier and Grossos, Céline and De Vries, Philine and Arnould, Myriam and Pelatan, Cécile and Geiss, Stephan and Laplace, Christophe and Kyheng, Maéva and Nicolas, Audrey and Aumar, Madeleine and Gottrand, Frédéric},\n\tyear = {2022},\n\tpmid = {35990006},\n\tpmcid = {PMC9387303},\n\tkeywords = {catch-up, growth, prematurity, small for gestational age, stunting, syndromic, undernutrition},\n\tpages = {969617},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Postoperative morbidity and health-related quality of life in children with delayed reconstruction of esophageal atresia: a nationwide Swedish study.\n \n \n \n\n\n \n Dellenmark-Blom, M.; Örnö Ax, S.; Öst, E.; Svensson, J. F.; Kassa, A.; Jönsson, L.; Abrahamsson, K.; Gatzinsky, V.; Stenström, P.; Tollne, A.; Omling, E.; and Engstrand Lilja, H.\n\n\n \n\n\n\n Orphanet Journal of Rare Diseases, 17(1): 239. June 2022.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{dellenmark-blom_postoperative_2022,\n\ttitle = {Postoperative morbidity and health-related quality of life in children with delayed reconstruction of esophageal atresia: a nationwide {Swedish} study},\n\tvolume = {17},\n\tissn = {1750-1172},\n\tshorttitle = {Postoperative morbidity and health-related quality of life in children with delayed reconstruction of esophageal atresia},\n\tdoi = {10.1186/s13023-022-02381-y},\n\tabstract = {BACKGROUND: In 10-15\\% of children with esophageal atresia (EA) delayed reconstruction of esophageal atresia (DREA) is necessary due to long-gap EA and/or prematurity/low birth weight. They represent a patient subgroup with high risk of complications. We aimed to evaluate postoperative morbidity and health-related quality of life (HRQOL) in a Swedish national cohort of children with DREA.\nMETHODS: Postoperative morbidity, age-specific generic HRQOL (PedsQL™ 4.0) and condition-specific HRQOL (The EA-QOL questionnaires) in children with DREA were compared with children with EA who had primary anastomosis (PA). Factors associated with the DREA group's HRQOL scores were analyzed using Mann-Whitney U-test and Spearman's rho. Clinical data was extracted from the medical records. Significance level was p {\\textless} 0.05.\nRESULTS: Thirty-four out of 45 families of children with DREA were included and 30 returned the questionnaires(n = 8 children aged 2-7 years; n = 22 children aged 8-18 years). Compared to children with PA(42 children aged 2-7 years; 64 children aged 8-18 years), there were no significant differences in most early postoperative complications. At follow-up, symptom prevalence in children aged 2-7 with DREA ranged from 37.5\\% (heartburn) to 75\\% (cough). Further digestive and respiratory symptoms were present in ≥ 50\\%. In children aged 8-18, it ranged from 14.3\\% (vomiting) to 40.9\\% (cough), with other digestive and airway symptoms present in 19.0-27.3\\%. Except for chest tightness (2-7 years), there were no significant differences in symptom prevalence between children with DREA and PA, nor between their generic or condition-specific HRQOL scores (p {\\textgreater} 0.05). More children with DREA underwent esophageal dilatations (both age groups), gastrostomy feeding (2-7 years), and antireflux treatment (8-18 years), p {\\textless} 0.05. Days to hospital discharge after EA repair and a number of associated anomalies showed a strong negative correlation with HRQOL scores (2-7 years). Presence of cough, airway infection, swallowing difficulties and heartburn were associated with lower HRQOL scores (8-18 years), p {\\textless} 0.05.\nCONCLUSIONS: Although children with DREA need more treatments, they are not a risk group for postoperative morbidity and impaired HRQOL compared with children with PA. However, those with a long initial hospital stay, several associated anomalies and digestive or respiratory symptoms risk worse HRQOL. This is important information for clinical practice, families and patient stakeholders.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Orphanet Journal of Rare Diseases},\n\tauthor = {Dellenmark-Blom, Michaela and Örnö Ax, Sofie and Öst, Elin and Svensson, Jan F. and Kassa, Ann-Marie and Jönsson, Linus and Abrahamsson, Kate and Gatzinsky, Vladimir and Stenström, Pernilla and Tollne, AnnaMaria and Omling, Erik and Engstrand Lilja, Helene},\n\tmonth = jun,\n\tyear = {2022},\n\tpmid = {35725462},\n\tpmcid = {PMC9207832},\n\tkeywords = {Child, Cough, Delayed reconstruction, Esophageal Atresia, Esophageal atresia, Health-related quality of life, Heartburn, Humans, Long-gap esophageal atresia, Long-term morbidity, Morbidity, Postoperative outcomes, Quality of Life, Sweden, Treatment Outcome},\n\tpages = {239},\n}\n\n\n\n\n\n\n\n

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\n BACKGROUND: In 10-15% of children with esophageal atresia (EA) delayed reconstruction of esophageal atresia (DREA) is necessary due to long-gap EA and/or prematurity/low birth weight. They represent a patient subgroup with high risk of complications. We aimed to evaluate postoperative morbidity and health-related quality of life (HRQOL) in a Swedish national cohort of children with DREA. METHODS: Postoperative morbidity, age-specific generic HRQOL (PedsQL™ 4.0) and condition-specific HRQOL (The EA-QOL questionnaires) in children with DREA were compared with children with EA who had primary anastomosis (PA). Factors associated with the DREA group's HRQOL scores were analyzed using Mann-Whitney U-test and Spearman's rho. Clinical data was extracted from the medical records. Significance level was p \\textless 0.05. RESULTS: Thirty-four out of 45 families of children with DREA were included and 30 returned the questionnaires(n = 8 children aged 2-7 years; n = 22 children aged 8-18 years). Compared to children with PA(42 children aged 2-7 years; 64 children aged 8-18 years), there were no significant differences in most early postoperative complications. At follow-up, symptom prevalence in children aged 2-7 with DREA ranged from 37.5% (heartburn) to 75% (cough). Further digestive and respiratory symptoms were present in ≥ 50%. In children aged 8-18, it ranged from 14.3% (vomiting) to 40.9% (cough), with other digestive and airway symptoms present in 19.0-27.3%. Except for chest tightness (2-7 years), there were no significant differences in symptom prevalence between children with DREA and PA, nor between their generic or condition-specific HRQOL scores (p \\textgreater 0.05). More children with DREA underwent esophageal dilatations (both age groups), gastrostomy feeding (2-7 years), and antireflux treatment (8-18 years), p \\textless 0.05. Days to hospital discharge after EA repair and a number of associated anomalies showed a strong negative correlation with HRQOL scores (2-7 years). Presence of cough, airway infection, swallowing difficulties and heartburn were associated with lower HRQOL scores (8-18 years), p \\textless 0.05. CONCLUSIONS: Although children with DREA need more treatments, they are not a risk group for postoperative morbidity and impaired HRQOL compared with children with PA. However, those with a long initial hospital stay, several associated anomalies and digestive or respiratory symptoms risk worse HRQOL. This is important information for clinical practice, families and patient stakeholders.\n

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\n \n\n \n \n \n \n \n British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults.\n \n \n \n\n\n \n Dhar, A.; Haboubi, H. N.; Attwood, S. E.; Auth, M. K. H.; Dunn, J. M.; Sweis, R.; Morris, D.; Epstein, J.; Novelli, M. R.; Hunter, H.; Cordell, A.; Hall, S.; Hayat, J. O.; Kapur, K.; Moore, A. R.; Read, C.; Sami, S. S.; Turner, P. J.; and Trudgill, N. J.\n\n\n \n\n\n\n Gut, 71(8): 1459–1487. August 2022.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{dhar_british_2022,\n\ttitle = {British {Society} of {Gastroenterology} ({BSG}) and {British} {Society} of {Paediatric} {Gastroenterology}, {Hepatology} and {Nutrition} ({BSPGHAN}) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults},\n\tvolume = {71},\n\tissn = {1468-3288},\n\tdoi = {10.1136/gutjnl-2022-327326},\n\tabstract = {BACKGROUND: Eosinophilic oesophagitis (EoE) is an increasingly common cause of dysphagia in both children and adults, as well as one of the most prevalent oesophageal diseases with a significant impact on physical health and quality of life. We have provided a single comprehensive guideline for both paediatric and adult gastroenterologists on current best practice for the evaluation and management of EoE.\nMETHODS: The Oesophageal Section of the British Society of Gastroenterology was commissioned by the Clinical Standards Service Committee to develop these guidelines. The Guideline Development Group included adult and paediatric gastroenterologists, surgeons, dietitians, allergists, pathologists and patient representatives. The Population, Intervention, Comparator and Outcomes process was used to generate questions for a systematic review of the evidence. Published evidence was reviewed and updated to June 2021. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system was used to assess the evidence and make recommendations. Two rounds of voting were held to assess the level of agreement and the strength of recommendations, with 80\\% consensus required for acceptance.\nRESULTS: Fifty-seven statements on EoE presentation, diagnosis, investigation, management and complications were produced with further statements created on areas for future research.\nCONCLUSIONS: These comprehensive adult and paediatric guidelines of the British Society of Gastroenterology and British Society of Paediatric Gastroenterology, Hepatology and Nutrition are based on evidence and expert consensus from a multidisciplinary group of healthcare professionals, including patient advocates and patient support groups, to help clinicians with the management patients with EoE and its complications.},\n\tlanguage = {eng},\n\tnumber = {8},\n\tjournal = {Gut},\n\tauthor = {Dhar, Anjan and Haboubi, Hasan N. and Attwood, Stephen E. and Auth, Marcus K. H. and Dunn, Jason M. and Sweis, Rami and Morris, Danielle and Epstein, Jenny and Novelli, Marco R. and Hunter, Hannah and Cordell, Amanda and Hall, Sharon and Hayat, Jamal O. and Kapur, Kapil and Moore, Andrew Robert and Read, Carol and Sami, Sarmed S. and Turner, Paul J. and Trudgill, Nigel J.},\n\tmonth = aug,\n\tyear = {2022},\n\tpmid = {35606089},\n\tpmcid = {PMC9279848},\n\tkeywords = {Adult, Child, Consensus, DIET, DYSPHAGIA, ENDOSCOPY, Eosinophilic Esophagitis, Gastroenterology, Humans, OESOPHAGEAL DISEASE, PAEDIATRIC GASTROENTEROLOGY, Quality of Life, Societies, Medical},\n\tpages = {1459--1487},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Endoscopic Gastrojejunostomy in Infants and Children.\n \n \n \n \n\n\n \n Elmehdi, S.; Ley, D.; Aumar, M.; Coopman, S.; Guimber, D.; Nicolas, A.; Antoine, M.; Turck, D.; Kyheng, M.; and Gottrand, F.\n\n\n \n\n\n\n The Journal of Pediatrics, 244: 115–119.e1. May 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Endoscopic$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{elmehdi_endoscopic_2022,\n\ttitle = {Endoscopic {Gastrojejunostomy} in {Infants} and {Children}},\n\tvolume = {244},\n\tissn = {1097-6833},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/35108546/},\n\tdoi = {10.1016/j.jpeds.2022.01.039},\n\tabstract = {OBJECTIVE: To evaluate the feasibility of endoscopic gastrojejunal tube (GJT) placement in infants and children.\nSTUDY DESIGN: All children undergoing endoscopic GJT placement between January 2010 and December 2019 were included in this single-center retrospective study. Difficulties with and failure of GJT placement, complication rates, and device longevity, efficacy, and duration were assessed.\nRESULTS: A total of 107 children, median age 10 months (IQR, 5.0-23.0 months) and median weight 6.6 kg (IQR, 5.3-9.5 kg), underwent endoscopic GJT placement using the gastric stoma to introduce the endoscope (one step: n = 36 of 107; 33.6\\%). Endoscopic placement was successful in 99\\%. Eight periprocedure complications occurred, including 1 pneumoperitoneum requiring exsufflation, 2 acute pulmonary hypertension episodes leading to death in 1 case, and 5 episodes of bronchospasm. Minor complications were frequent and mostly mechanical (79\\%), whereas major complications were rare (5.6\\%): intussusception (n = 4), intestinal perforation (n = 1), and pneumoperitoneum (n = 1). Ten patients died. Of the 97 patients who lived, 85 (87\\%) were weaned from jejunal feeding at a median of 179 days (IQR, 69-295 days) after initiation. Among them, 30 (35.2\\%) required fundoplication. Weight for age z-score was significantly higher at weaning.\nCONCLUSIONS: GJT placement is feasible in children, even low-weight infants. Complications are frequent but are mostly minor.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Elmehdi, Sophia and Ley, Delphine and Aumar, Madeleine and Coopman, Stéphanie and Guimber, Dominique and Nicolas, Audrey and Antoine, Matthieu and Turck, Dominique and Kyheng, Maeva and Gottrand, Frédéric},\n\tmonth = may,\n\tyear = {2022},\n\tpmid = {35108546},\n\tkeywords = {Child, Enteral Nutrition, Gastric Bypass, Gastrostomy, Humans, Infant, Intubation, Gastrointestinal, Pneumoperitoneum, Retrospective Studies},\n\tpages = {115--119.e1},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Congenital gastrointestinal disorders. Why is it relevant to adult gastroenterologists?.\n \n \n \n \n\n\n \n Gottrand, F.; and Turck, D.\n\n\n \n\n\n\n Best Practice & Research. Clinical Gastroenterology, 56-57: 101787. 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Congenital$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gottrand_congenital_2022,\n\ttitle = {Congenital gastrointestinal disorders. {Why} is it relevant to adult gastroenterologists?},\n\tvolume = {56-57},\n\tissn = {1532-1916},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/35331398/},\n\tdoi = {10.1016/j.bpg.2022.101787},\n\tlanguage = {eng},\n\tjournal = {Best Practice \\& Research. Clinical Gastroenterology},\n\tauthor = {Gottrand, F. and Turck, D.},\n\tyear = {2022},\n\tpmid = {35331398},\n\tkeywords = {Adult, Gastroenterologists, Gastroenterology, Gastrointestinal Diseases, Humans, Practice Patterns, Physicians'},\n\tpages = {101787},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Comparison of Endoscopic Dilatation and Heller's Myotomy for Treating Esophageal Achalasia in Children: A Multicenter Study.\n \n \n \n \n\n\n \n Nicolas, A.; Aumar, M.; Tran, L. C.; Tiret, A.; Duclaux-Loras, R.; Bridoux-Henno, L.; Campeotto, F.; Fabre, A.; Breton, A.; Languepin, J.; Kyheng, M.; Viala, J.; Coopman, S.; and Gottrand, F.\n\n\n \n\n\n\n The Journal of Pediatrics, 251: 134–139.e2. December 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Comparison$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{nicolas_comparison_2022,\n\ttitle = {Comparison of {Endoscopic} {Dilatation} and {Heller}'s {Myotomy} for {Treating} {Esophageal} {Achalasia} in {Children}: {A} {Multicenter} {Study}},\n\tvolume = {251},\n\tissn = {1097-6833},\n\tshorttitle = {Comparison of {Endoscopic} {Dilatation} and {Heller}'s {Myotomy} for {Treating} {Esophageal} {Achalasia} in {Children}},\n\turl = {http://hdl.handle.net/20.500.12210/78896},\n\tdoi = {10.1016/j.jpeds.2022.07.010},\n\tabstract = {OBJECTIVE: To compare the efficacy of, and complications from, the 2 main treatments for achalasia: endoscopic dilatation and surgical cardiomyotomy (Heller's myotomy).\nSTUDY DESIGN: We retrospectively collected data on children treated for achalasia over an 11-year period from 8 tertiary pediatric centers. A line of treatment was defined as performing either Heller's myotomy or 1-3 sessions of endoscopy dilatation over 3 months. Treatment success was a priori defined as clinical improvement and no need for new treatment.\nRESULTS: Ninety-seven children (median age, 12 years; 57\\% boys) were included. The median time to diagnosis was 10.5 months, and the median follow-up period was 27 months. Thirty-seven children were treated by Heller's myotomy and 60 by endoscopy dilatation as the first-line treatment. After adjustment for potentially confounding factors, Heller's myotomy was significantly more successful than endoscopy dilatation (hazard ratio, 3.93 [1.74; 8.88]; P = .001), with a median survival without failure of 49 and 7 months, respectively, and with no significant difference in the occurrence of complications (35.2\\% for Heller's myotomy, 29.7\\% for endoscopy dilatation, P = .56). Hydrostatic dilatation was as successful as pneumatic dilatation (hazard ratio, 1.35 [0.56; 3.23]; P = .50).\nCONCLUSIONS: Heller's myotomy is more successful than endoscopy dilatation, with no significant difference in the occurrence of serious complications. This raises the potential role of peroral endoscopic myotomy as an alternative treatment to Heller's myotomy.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Nicolas, Audrey and Aumar, Madeleine and Tran, Léa Chantal and Tiret, Alice and Duclaux-Loras, Rémi and Bridoux-Henno, Laure and Campeotto, Florence and Fabre, Alexandre and Breton, Anne and Languepin, Jeanne and Kyheng, Maéva and Viala, Jérôme and Coopman, Stéphanie and Gottrand, Frédéric},\n\tmonth = dec,\n\tyear = {2022},\n\tpmid = {35853483},\n\tkeywords = {Child, Dilatation, Endoscopy, Esophageal Achalasia, Female, Heller Myotomy, Heller's myotomy, Humans, Male, Retrospective Studies, achalasia, children, endoscopic dilatation},\n\tpages = {134--139.e2},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Weaning children from prolonged enteral nutrition: A position paper.\n \n \n \n \n\n\n \n Clouzeau, H.; Dipasquale, V.; Rivard, L.; Lecoeur, K.; Lecoufle, A.; Le Ru-Raguénès, V.; Guimber, D.; Leblanc, V.; Malécot-Le Meur, G.; Baeckeroot, S.; Van Malleghem, A.; Loras-Duclaux, I.; Rubio, A.; Genevois-Peres, A.; Dubedout, S.; Bué-Chevalier, M.; Bellaïche, M.; Abadie, V.; and Gottrand, F.\n\n\n \n\n\n\n European Journal of Clinical Nutrition, 76(4): 505–515. April 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Weaning$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{clouzeau_weaning_2022,\n\ttitle = {Weaning children from prolonged enteral nutrition: {A} position paper},\n\tvolume = {76},\n\tissn = {1476-5640},\n\tshorttitle = {Weaning children from prolonged enteral nutrition},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/34462558/},\n\tdoi = {10.1038/s41430-021-00992-5},\n\tabstract = {Enteral nutrition (EN) allows adequate nutritional intake in children for whom oral intake is impossible, insufficient or unsafe. With maturation and health improvements, most children ameliorate oral skills and become able to eat orally, therefore weaning from EN becomes a therapeutic goal. No recommendations currently exist on tube weaning, and practices vary widely between centres. With this report, the French Network of Rare Digestive Diseases (FIMATHO) and the French-Speaking Group of Paediatric Hepatology, Gastroenterology and Nutrition (GFHGNP) aim to develop uniform clinical practice recommendations for weaning children from EN. A multidisciplinary working group (WG) encompassing paediatricians, paediatric gastroenterologists, speech-language therapists, psychologists, dietitians and occupational therapists, was formed in June 2018. A systematic literature search was performed on those published from January 1, 1998, to April 30, 2020, using MEDLINE. After several rounds of e-discussions, relevant items for paediatric tube weaning were identified, and recommendations were developed, discussed and finalized. The WG members voted on each recommendation using a nominal voting technique. Expert opinion was applied to support the recommendations where no high-quality studies were available.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {European Journal of Clinical Nutrition},\n\tauthor = {Clouzeau, Haude and Dipasquale, Valeria and Rivard, Laila and Lecoeur, Katia and Lecoufle, Audrey and Le Ru-Raguénès, Valérie and Guimber, Dominique and Leblanc, Véronique and Malécot-Le Meur, Gaelle and Baeckeroot, Sophie and Van Malleghem, Audrey and Loras-Duclaux, Irène and Rubio, Amandine and Genevois-Peres, Aline and Dubedout, Sophie and Bué-Chevalier, Mélanie and Bellaïche, Marc and Abadie, Véronique and Gottrand, Frédéric},\n\tmonth = apr,\n\tyear = {2022},\n\tpmid = {34462558},\n\tkeywords = {Child, Enteral Nutrition, Humans, Nutritional Status, Practice Guidelines as Topic, Weaning},\n\tpages = {505--515},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Prevalence of acid gastroesophageal reflux disease in infants with esophageal atresia/tracheoesophageal fistula.\n \n \n \n \n\n\n \n Flatrès, C.; Aumar, M.; Ley, D.; Sfeir, R.; Nicolas, A.; Bonnevalle, M.; Duhamel, A.; and Gottrand, F.\n\n\n \n\n\n\n Pediatric Research, 91(4): 977–983. March 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Prevalence$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{flatres_prevalence_2022,\n\ttitle = {Prevalence of acid gastroesophageal reflux disease in infants with esophageal atresia/tracheoesophageal fistula},\n\tvolume = {91},\n\tissn = {1530-0447},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/33864015/},\n\tdoi = {10.1038/s41390-021-01510-w},\n\tabstract = {BACKGROUND: Given the high prevalence and complication risks of acid gastroesophageal reflux (GERD) in the first months of life in infants with esophageal atresia, the ESPGHAN/NASPGHAN consensus statement recommends systematic treatment with proton pump inhibitors (PPIs) until the age of 1 year and checking for acid GERD thereafter. However, these recommendations have not been evaluated.\nMETHODS: This prospective study was conducted from 2007 to 2016. We evaluated the prevalence of acid GERD in 100 consecutive infants presenting with esophageal atresia/tracheoesophageal fistula after the age of 18 months when PPI treatment was stopped. The diagnosis of acid GERD was based on positive pH-metry and/or evidence of complications (e.g., peptic esophagitis, need for jejunal nutrition, or antireflux surgery). Those with acid GERD at a median age of 18 months received a control examination every year or adapted to their clinical situation.\nRESULTS: The prevalence rates of acid GERD were 64.3\\% at 18 months and 22.8\\% at the last follow-up (median age 65 months).There is no risk factor for acid GERD identified.\nCONCLUSIONS: This study shows a high prevalence of acid GERD in late infancy and supports the recommendation of systematic checking for acid GERD when treatment with PPI is stopped.\nIMPACT: Acid gastroesophageal reflux disease (GERD) is a frequent complication of esophageal atresia in infants. The ESPGHAN/NASPGHAN consensus, which is based on expert opinion, recommends systematic treatment of children with PPI until the age of 1 year. The prevalence rates of acid GERD were 64.3\\% at 18 months and 22.8\\% at the last follow-up. This study shows a high prevalence of acid GERD in late infancy and supports the recommendation of systematic checking for acid GERD when treatment with PPI is stopped.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Pediatric Research},\n\tauthor = {Flatrès, Charlotte and Aumar, Madeleine and Ley, Delphine and Sfeir, Rony and Nicolas, Audrey and Bonnevalle, Michel and Duhamel, Alain and Gottrand, Frédéric},\n\tmonth = mar,\n\tyear = {2022},\n\tpmid = {33864015},\n\tkeywords = {Child, Child, Preschool, Esophageal Atresia, Gastroesophageal Reflux, Humans, Infant, Prevalence, Prospective Studies, Proton Pump Inhibitors, Tracheoesophageal Fistula},\n\tpages = {977--983},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Predictors of anastomotic strictures following œsophageal atresia repair.\n \n \n \n \n\n\n \n Aumar, M.; Sfeir, R.; Pierache, A.; Turck, D.; Gottrand, F.; and CRACMO\n\n\n \n\n\n\n Archives of Disease in Childhood. Fetal and Neonatal Edition, 107(5): 545–550. September 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Predictors$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{aumar_predictors_2022,\n\ttitle = {Predictors of anastomotic strictures following œsophageal atresia repair},\n\tvolume = {107},\n\tissn = {1468-2052},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/35217569/},\n\tdoi = {10.1136/archdischild-2021-322577},\n\tabstract = {OBJECTIVES: To identify the risk factors for anastomotic, refractory and recurrent strictures and to establish whether anastomotic stricture is associated with antireflux surgery.\nDESIGN: This prospective national multicentre study included all infants born with oesophageal atresia (OA) over an 8-year period. Data on OA and complications were collected at birth and at 1 year old. Univariate and multivariate analyses were conducted.\nRESULTS: 1082 patients from 37 centres were included in the study. The prevalence of anastomotic stricture at 1 year old was 23.2\\%. Anastomosis under tension (defined by the surgeon at the time of repair) and delayed anastomosis (defined as anastomosis performed more than 15 days after birth, excluding delays due to prematurity or severe cardiac diseases) were found to be independent risk factors for anastomotic stricture (2.3 (1.42-3.74) and 4.02 (2.12-7.63), respectively). Patients with anastomotic stricture had a 2.3-fold higher rate of fundoplication compared with others (p=0.001). Anastomosis under tension and delayed anastomosis were found to be independent risk factors for recurrent stricture (1.92 (1.10-3.34) and 5.73 (2.71-12.14), respectively), while delayed anastomosis was the only risk factor for refractory stricture (8.30 (3.34-20.64)). There was a 2.39-fold (1.42-4.04) higher rate of fundoplication in the anastomotic stricture group than in the group without anastomotic stricture (p=0.001).\nCONCLUSIONS: Patient-related anatomical factors leading to anastomosis under tension and delayed anastomosis increase the risk of anastomotic stricture.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Archives of Disease in Childhood. Fetal and Neonatal Edition},\n\tauthor = {Aumar, Madeleine and Sfeir, Rony and Pierache, Adeline and Turck, Dominique and Gottrand, Frederic and {CRACMO}},\n\tmonth = sep,\n\tyear = {2022},\n\tpmid = {35217569},\n\tkeywords = {Anastomosis, Surgical, Constriction, Pathologic, Esophageal Atresia, Esophageal Stenosis, Humans, Infant, Infant, Newborn, Postoperative Complications, Prospective Studies, Retrospective Studies, epidemiology, gastroenterology, neonatology, paediatrics},\n\tpages = {545--550},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Long term digestive outcome of œsophageal atresia.\n \n \n \n \n\n\n \n Madeleine, A.; Audrey, N.; Rony, S.; David, S.; and Frédéric, G.\n\n\n \n\n\n\n Best Practice & Research. Clinical Gastroenterology, 56-57: 101771. 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Long$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{madeleine_long_2022,\n\ttitle = {Long term digestive outcome of œsophageal atresia},\n\tvolume = {56-57},\n\tissn = {1532-1916},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/35331402/},\n\tdoi = {10.1016/j.bpg.2021.101771},\n\tabstract = {Œsophageal atresia is a rare neonatal malformation consisting in an interruption of the continuity of the œsophagus, with or without a tracheo-œsophageal fistula. Although mortality rate is now low and most cases can benefit from successful surgical repair soon after birth, morbidity -specially digestive and nutritional-remains high. Many of the adults born with œsophageal atresia will suffer from dysphagia, gastro-œsophageal reflux and/or œsophageal dysmotility, leading to nutritional consequences and quality of life impairment. Barrett's œsophagus, potential risk of œsophageal cancer as well as risk of anastomotic stenosis and eosinophilic œsophagitis justify transition to adulthood and a lifelong prolonged follow-up.},\n\tlanguage = {eng},\n\tjournal = {Best Practice \\& Research. Clinical Gastroenterology},\n\tauthor = {Madeleine, Aumar and Audrey, Nicolas and Rony, Sfeir and David, Seguy and Frédéric, Gottrand},\n\tyear = {2022},\n\tpmid = {35331402},\n\tkeywords = {Adolescent, Adult, Barrett œsophagus, Dysphagia, Eosinophilic œsophagitis, Esophageal Atresia, Esophagitis, Peptic, Gastro-œsophageal reflux, Humans, Infant, Newborn, Neonatal surgery, Quality of Life, Tracheoesophageal Fistula, Transition, Œsophageal atresia, œsophageal cancer, œsophageal dysmotility},\n\tpages = {101771},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Feeding disorders in children with oesophageal atresia: a cross-sectional study.\n \n \n \n \n\n\n \n Pham, A.; Ecochard-Dugelay, E.; Bonnard, A.; Le Roux, E.; Gelas, T.; Rousseau, V.; Thomassin, N.; Cabon-Boudard, I.; Nicolas, A.; Guinot, A.; Rebeuh, J.; Le Mandat, A.; Djeddi, D.; Fouquet, V.; Boucharny, A.; Irtan, S.; Lemale, J.; Comte, A.; Bridoux-Henno, L.; Dupont-Lucas, C.; Dimitrov, G.; Turquet, A.; Borderon, C.; Pelatan, C.; Chaillou Legault, E.; Jung, C.; Willot, S.; Montalva, L.; Mitanchez, D.; Gottrand, F.; and Bellaiche, M.\n\n\n \n\n\n\n Archives of Disease in Childhood, 107(1): 52–58. January 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Feeding$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{pham_feeding_2022,\n\ttitle = {Feeding disorders in children with oesophageal atresia: a cross-sectional study},\n\tvolume = {107},\n\tissn = {1468-2044},\n\tshorttitle = {Feeding disorders in children with oesophageal atresia},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/33863700/},\n\tdoi = {10.1136/archdischild-2020-320609},\n\tabstract = {INTRODUCTION: With advances in surgical and neonatal care, the survival of patients with oesophageal atresia (OA) has improved over time. Whereas a number of OA-related conditions (delayed primary anastomosis, anastomotic stricture and oesophageal dysmotility) may have an impact on feeding development and although children with OA experience several oral aversive events, paediatric feeding disorders (PFD) remain poorly described in this population. The primary aim of our study was to describe PFD in children born with OA, using a standardised scale. The secondary aim was to determine conditions associated with PFD.\nMETHODS: The Feeding Disorders in Children with Oesophageal Atresia Study is a national cohort study based on the OA registry from the French National Network. Parents of children born with OA between 2013 and 2016 in one of the 22 participating centres were asked to complete the French version of the Montreal Children's Hospital Feeding Scale.\nRESULTS: Of the 248 eligible children, 145 children, with a median age of 2.3 years (Q1-Q3 1.8-2.9, min-max 1.1-4.0 years), were included. Sixty-one children (42\\%) developed PFD; 13\\% were tube-fed (n=19). Almost 40\\% of children with PFD failed to thrive (n=23). The presence of chronic respiratory symptoms was associated with the development of PFD. Ten children with PFD (16\\%) had no other condition or OA-related complication.\nCONCLUSION: PFD are common in children with OA, and there is no typical profile of patients at risk of PFD. Therefore, all children with OA require a systematic screening for PFD that could improve the care and outcomes of patients, especially in terms of growth.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Archives of Disease in Childhood},\n\tauthor = {Pham, Aurélie and Ecochard-Dugelay, Emmanuelle and Bonnard, Arnaud and Le Roux, Enora and Gelas, Thomas and Rousseau, Véronique and Thomassin, Nadège and Cabon-Boudard, Isabelle and Nicolas, Audrey and Guinot, Audrey and Rebeuh, Julie and Le Mandat, Aurélie and Djeddi, Djamal-Dine and Fouquet, Virginie and Boucharny, Aurélie and Irtan, Sabine and Lemale, Julie and Comte, Aurélie and Bridoux-Henno, Laure and Dupont-Lucas, Claire and Dimitrov, Georges and Turquet, Anne and Borderon, Corinne and Pelatan, Cécile and Chaillou Legault, Emilie and Jung, Camille and Willot, Stéphanie and Montalva, Louise and Mitanchez, Delphine and Gottrand, Frederic and Bellaiche, Marc},\n\tmonth = jan,\n\tyear = {2022},\n\tpmid = {33863700},\n\tkeywords = {Anastomosis, Surgical, Child, Preschool, Cohort Studies, Cross-Sectional Studies, Enteral Nutrition, Esophageal Atresia, Feeding and Eating Disorders, Female, France, Humans, Infant, Male, Postoperative Complications, Prevalence, gastroenterology, growth, neonatology, occupational therapy},\n\tpages = {52--58},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Exome sequencing efficacy and phenotypic expansions involving esophageal atresia/tracheoesophageal fistula plus.\n \n \n \n \n\n\n \n Sy, M. R.; Chauhan, J.; Prescott, K.; Imam, A.; Kraus, A.; Beleza, A.; Salkeld, L.; Hosdurga, S.; Parker, M.; Vasudevan, P.; Islam, L.; Goel, H.; Bain, N.; Park, S.; Mohammed, S.; Dieterich, K.; Coutton, C.; Satre, V.; Vieville, G.; Donaldson, A.; Beneteau, C.; Ghoumid, J.; Van Den Bogaert, K.; Boogaerts, A.; Boudry, E.; Vanlerberghe, C.; Petit, F.; Bernardini, L.; Torres, B.; Mattina, T.; Carli, D.; Mandrile, G.; Pinelli, M.; Brunetti-Pierri, N.; Neas, K.; Beddow, R.; Tørring, P. M.; Faletra, F.; Spedicati, B.; Gasparini, P.; Mussa, A.; Ferrero, G. B.; Lampe, A.; Lam, W.; Bi, W.; Bacino, C. A.; Kuwahara, A.; Bush, J. O.; Zhao, X.; Luna, P. N.; Shaw, C. A.; Rosenfeld, J. A.; and Scott, D. A.\n\n\n \n\n\n\n American Journal of Medical Genetics. Part A, 188(12): 3492–3504. December 2022.\n \n\n\n\n
\n\n\n\n \n \n $\"Exome$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{sy_exome_2022,\n\ttitle = {Exome sequencing efficacy and phenotypic expansions involving esophageal atresia/tracheoesophageal fistula plus},\n\tvolume = {188},\n\tissn = {1552-4833},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/36135330/},\n\tdoi = {10.1002/ajmg.a.62976},\n\tabstract = {Esophageal atresia/tracheoesophageal fistula (EA/TEF) is a life-threatening birth defect that often occurs with other major birth defects (EA/TEF+). Despite advances in genetic testing, a molecular diagnosis can only be made in a minority of EA/TEF+ cases. Here, we analyzed clinical exome sequencing data and data from the DECIPHER database to determine the efficacy of exome sequencing in cases of EA/TEF+ and to identify phenotypic expansions involving EA/TEF. Among 67 individuals with EA/TEF+ referred for clinical exome sequencing, a definitive or probable diagnosis was made in 11 cases for an efficacy rate of 16\\% (11/67). This efficacy rate is significantly lower than that reported for other major birth defects, suggesting that polygenic, multifactorial, epigenetic, and/or environmental factors may play a particularly important role in EA/TEF pathogenesis. Our cohort included individuals with pathogenic or likely pathogenic variants that affect TCF4 and its downstream target NRXN1, and FANCA, FANCB, and FANCC, which are associated with Fanconi anemia. These cases, previously published case reports, and comparisons to other EA/TEF genes made using a machine learning algorithm, provide evidence in support of a potential pathogenic role for these genes in the development of EA/TEF.},\n\tlanguage = {eng},\n\tnumber = {12},\n\tjournal = {American Journal of Medical Genetics. Part A},\n\tauthor = {Sy, Mary R. and Chauhan, Jaynee and Prescott, Katrina and Imam, Aliza and Kraus, Alison and Beleza, Ana and Salkeld, Lee and Hosdurga, Saraswati and Parker, Michael and Vasudevan, Pradeep and Islam, Lily and Goel, Himanshu and Bain, Nicole and Park, Soo-Mi and Mohammed, Shehla and Dieterich, Klaus and Coutton, Charles and Satre, Véronique and Vieville, Gaëlle and Donaldson, Alan and Beneteau, Claire and Ghoumid, Jamal and Van Den Bogaert, Kris and Boogaerts, Anneleen and Boudry, Elise and Vanlerberghe, Clémence and Petit, Florence and Bernardini, Laura and Torres, Barbara and Mattina, Teresa and Carli, Diana and Mandrile, Giorgia and Pinelli, Michele and Brunetti-Pierri, Nicola and Neas, Katherine and Beddow, Rachel and Tørring, Pernille M. and Faletra, Flavio and Spedicati, Beatrice and Gasparini, Paolo and Mussa, Alessandro and Ferrero, Giovanni Battista and Lampe, Anne and Lam, Wayne and Bi, Weimin and Bacino, Carlos A. and Kuwahara, Akela and Bush, Jeffrey O. and Zhao, Xiaonan and Luna, Pamela N. and Shaw, Chad A. and Rosenfeld, Jill A. and Scott, Daryl A.},\n\tmonth = dec,\n\tyear = {2022},\n\tpmid = {36135330},\n\tpmcid = {PMC9669235},\n\tkeywords = {Esophageal Atresia, Exome, Exome Sequencing, Fanconi anemia, Humans, NRXN1, TCF4, Tracheoesophageal Fistula, esophageal atresia, exome sequencing, tracheoesophageal fistula},\n\tpages = {3492--3504},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Quality of life was similar in children with congenital diaphragmatic hernia and oesophageal atresia and related to respiratory morbidity.\n \n \n \n \n\n\n \n Darmaun, L.; Lejeune, S.; Drumez, E.; Mur, S.; de Langle-Chevalier, F.; Nève, V.; Storme, L.; Michaud, L.; Gottrand, F.; Thumerelle, C.; and Deschildre, A.\n\n\n \n\n\n\n Acta Paediatrica (Oslo, Norway: 1992), 110(2): 695–703. February 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"Quality$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{darmaun_quality_2021,\n\ttitle = {Quality of life was similar in children with congenital diaphragmatic hernia and oesophageal atresia and related to respiratory morbidity},\n\tvolume = {110},\n\tissn = {1651-2227},\n\turl = {http://hdl.handle.net/20.500.12210/40704},\n\tdoi = {10.1111/apa.15426},\n\tabstract = {AIM: To assess quality of life (QoL) in children with congenital diaphragmatic hernia (CDH) and to compare it with oesophageal atresia (OA).\nMETHODS: A cross-sectional study in CDH children (≥7 years) was conducted in Lille University Hospital, France, from January 2013 to April 2014. History, lung function (rest, exercise) and Pediatric Quality of Life Inventory questionnaires (PedsQoL 4.0) were collected. Data of OA children were previously published.\nRESULTS: Fifty-four CDH patients (male: 53\\%, median age: 11 years, IQR 9-14) were compared to 54 OA patients (male: 61\\%, median age: 13 years, IQR: 11-15). CDH children had significantly more frequent history of pneumonia (30\\% vs 13\\%), exercise limitation (54\\% vs 35\\%) and chest deformity (39\\% vs 11\\%); 46\\% had an obstructive pattern and 66\\% an abnormal cardiopulmonary exercise test. The median PedsQoL total score in children was 81 (IQR 73-90) in CDH and 81 (IQR 72-91) in OA (P = .8). In CDH, duration of neonatal oxygen therapy, hospitalisation for respiratory disease, exercise limitation, inhaled corticosteroids treatment, chest deformity, abnormal cardiopulmonary exercise test and lower forced expiratory volume in one second were significantly associated with lower QoL scores.\nCONCLUSION: PedsQoL scores remained satisfactory in CDH children with CDH, with no difference compared to OA. Patients with respiratory morbidity and lung function impairment, who displayed lower scores, should be identified in order to optimise their management in reference centres.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Acta Paediatrica (Oslo, Norway: 1992)},\n\tauthor = {Darmaun, Laura and Lejeune, Stephanie and Drumez, Elodie and Mur, Sebastien and de Langle-Chevalier, Fanny and Nève, Véronique and Storme, Laurent and Michaud, Laurent and Gottrand, Frederic and Thumerelle, Caroline and Deschildre, Antoine},\n\tmonth = feb,\n\tyear = {2021},\n\tpmid = {32567053},\n\tkeywords = {Adolescent, Child, Cross-Sectional Studies, Esophageal Atresia, France, Hernias, Diaphragmatic, Congenital, Humans, Infant, Newborn, Male, Morbidity, Quality of Life, congenital diaphragmatic hernia, lung function tests, oesophageal atresia, quality of life, respiratory morbidity},\n\tpages = {695--703},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Esophageal Atresia and Respiratory Morbidity.\n \n \n \n \n\n\n \n Lejeune, S.; Sfeir, R.; Rousseau, V.; Bonnard, A.; Gelas, T.; Aumar, M.; Panait, N.; Rabattu, P.; Irtan, S.; Fouquet, V.; Le Mandat, A.; Cocci, S. D. N.; Habonimana, E.; Lamireau, T.; Lemelle, J.; Elbaz, F.; Talon, I.; Boudaoud, N.; Allal, H.; Buisson, P.; Petit, T.; Sapin, E.; Lardy, H.; Schmitt, F.; Levard, G.; Scalabre, A.; Michel, J.; Jaby, O.; Pelatan, C.; De Vries, P.; Borderon, C.; Fourcade, L.; Breaud, J.; Arnould, M.; Tolg, C.; Chaussy, Y.; Geiss, S.; Laplace, C.; Drumez, E.; El Mourad, S.; Thumerelle, C.; and Gottrand, F.\n\n\n \n\n\n\n Pediatrics, 148(3): e2020049778. September 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"Esophageal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{lejeune_esophageal_2021,\n\ttitle = {Esophageal {Atresia} and {Respiratory} {Morbidity}},\n\tvolume = {148},\n\tissn = {1098-4275},\n\turl = {http://hdl.handle.net/20.500.12210/79191},\n\tdoi = {10.1542/peds.2020-049778},\n\tabstract = {BACKGROUND AND OBJECTIVES: Respiratory diseases are common in children with esophageal atresia (EA), leading to increased morbidity and mortality in the first year. The primary study objective was to identify the factors associated with readmissions for respiratory causes in the first year in EA children.\nMETHODS: A population-based study. We included all children born between 2008 and 2016 with available data and analyzed factors at birth and 1 year follow-up. Factors with a P value {\\textless}.10 in univariate analyses were retained in logistic regression models.\nRESULTS: Among 1460 patients born with EA, 97 (7\\%) were deceased before the age of 1 year, and follow-up data were available for 1287 patients, who constituted our study population. EAs were Ladd classification type III or IV in 89\\%, preterm birth was observed in 38\\%, and associated malformations were observed in 52\\%. Collectively, 61\\% were readmitted after initial discharge in the first year, 31\\% for a respiratory cause. Among these, respiratory infections occurred in 64\\%, and 35\\% received a respiratory treatment. In logistic regression models, factors associated with readmission for a respiratory cause were recurrence of tracheoesophageal fistula, aortopexy, antireflux surgery, and tube feeding; factors associated with respiratory treatment were male sex and laryngeal cleft.\nCONCLUSIONS: Respiratory morbidity in the first year after EA repair is frequent, accounting for {\\textgreater}50\\% of readmissions. Identifying high risk groups of EA patients (ie, those with chronic aspiration, anomalies of the respiratory tract, and need for tube feeding) may guide follow-up strategies.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Pediatrics},\n\tauthor = {Lejeune, Stéphanie and Sfeir, Rony and Rousseau, Véronique and Bonnard, Arnaud and Gelas, Thomas and Aumar, Madeleine and Panait, Nicoleta and Rabattu, Pierre-Yves and Irtan, Sabine and Fouquet, Virginie and Le Mandat, Aurélie and Cocci, Stephan De Napoli and Habonimana, Edouard and Lamireau, Thierry and Lemelle, Jean-Louis and Elbaz, Frédéric and Talon, Isabelle and Boudaoud, Nadia and Allal, Hossein and Buisson, Philippe and Petit, Thierry and Sapin, Emmanuel and Lardy, Hubert and Schmitt, Françoise and Levard, Guillaume and Scalabre, Aurélien and Michel, Jean-Luc and Jaby, Olivier and Pelatan, Cécile and De Vries, Philine and Borderon, Corinne and Fourcade, Laurent and Breaud, Jean and Arnould, Myriam and Tolg, Cécilia and Chaussy, Yann and Geiss, Stephan and Laplace, Christophe and Drumez, Elodie and El Mourad, Sawsan and Thumerelle, Caroline and Gottrand, Frédéric},\n\tmonth = sep,\n\tyear = {2021},\n\tpmid = {34413249},\n\tkeywords = {Cohort Studies, Congenital Abnormalities, Enteral Nutrition, Esophageal Atresia, Female, Follow-Up Studies, France, Gastroesophageal Reflux, Humans, Infant, Infant, Small for Gestational Age, Male, Patient Readmission, Premature Birth, Registries, Respiration Disorders, Tracheoesophageal Fistula},\n\tpages = {e2020049778},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n STAT6 Variants Associate With Relapse of Eosinophilic Esophagitis in Patients Receiving Long-term Proton Pump Inhibitor Therapy.\n \n \n \n\n\n \n Mougey, E. B.; Nguyen, V.; Gutiérrez-Junquera, C.; Fernández-Fernández, S.; Cilleruelo, M. L.; Rayo, A.; Borrell, B.; Román, E.; González-Lois, C.; Chao, M.; Al-Atrash, H.; and Franciosi, J. P.\n\n\n \n\n\n\n Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 19(10): 2046–2053.e2. October 2021.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{mougey_stat6_2021,\n\ttitle = {{STAT6} {Variants} {Associate} {With} {Relapse} of {Eosinophilic} {Esophagitis} in {Patients} {Receiving} {Long}-term {Proton} {Pump} {Inhibitor} {Therapy}},\n\tvolume = {19},\n\tissn = {1542-7714},\n\tdoi = {10.1016/j.cgh.2020.08.020},\n\tabstract = {BACKGROUND \\& AIMS: Based on histologic features, variants in STAT6 are associated with a poor initial response to proton pump inhibitor (PPI) therapy in pediatric patients with eosinophilic esophagitis (EoE). We investigated whether these genetic variants are associated with a poor long-term response in children with EoE who initially responded to PPI therapy.\nMETHODS: We performed a prospective longitudinal cohort study of children ages 2 to 16 years who met the diagnostic criteria for EoE (≥15 eosinophils/high-power field [eos/hpf]), responded to 8 weeks of treatment with 2 mg/kg/d PPI ({\\textless}15 eos/hpf), and whose dose then was reduced to 1 mg/kg/d PPI (maintenance therapy) for 1 year, at which point biopsy specimens were collected by endoscopy. Genomic DNA was isolated from formalin-fixed paraffin-embedded biopsy tissue and was genotyped for variants of STAT6. Remission of inflammation was assessed at eos/hpf thresholds of {\\textless}15 and ≤5.\nRESULTS: Among 73 patients who received 1 mg/kg/d PPI maintenance therapy for 1 year, 13 patients (18\\%) had 6 to 14 eos/hpf, 36 patients (49\\%) had 5 or fewer eos/hpf, and 24 patients (33\\%) relapsed to EoE (≥15 eos/hpf). Carriage of any of 3 STAT6 variants in linkage disequilibrium (r2 ≥0.8; rs324011, rs167769, or rs12368672) was associated with a 2.3- to 2.8-fold increase in the odds of EoE relapse, and with a 2.8- to 4.1-fold increase in the odds of having 6 to 14 eos/hpf. For rs324011, the odds ratio [95\\% CI] for relapse was 2.77 [1.11, 6.92]; P = .029, and the odds ratio [95\\% CI] for having 6 to 14 eos/hpf was 3.06 [1.27, 7.36]; P = .012.\nCONCLUSIONS: Pediatric EoE patients who initially respond to PPI therapy and carry STAT6 variants rs324011, rs167769, or rs12368672 are at increased risk of relapse after 1 year of PPI maintenance therapy.},\n\tlanguage = {eng},\n\tnumber = {10},\n\tjournal = {Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association},\n\tauthor = {Mougey, Edward B. and Nguyen, Vivian and Gutiérrez-Junquera, Carolina and Fernández-Fernández, Sonia and Cilleruelo, Maria Luz and Rayo, Ana and Borrell, Belén and Román, Enriqueta and González-Lois, Carmen and Chao, Montserrat and Al-Atrash, Hadeel and Franciosi, James P.},\n\tmonth = oct,\n\tyear = {2021},\n\tpmid = {32798708},\n\tkeywords = {Adolescent, Biomarker, Child, Child, Preschool, Eosinophilic Esophagitis, Esophagus, Humans, Immune Response, Longitudinal Studies, Prospective Studies, Proton Pump Inhibitors, Recurrence, Response to Treatment, STAT6 Transcription Factor},\n\tpages = {2046--2053.e2},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Proton-Pump Inhibitors: Do Children Break a Leg by Using Them?.\n \n \n \n\n\n \n Tavares, M.; and Amil-Dias, J.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 73(6): 665–669. December 2021.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{tavares_proton-pump_2021,\n\ttitle = {Proton-{Pump} {Inhibitors}: {Do} {Children} {Break} a {Leg} by {Using} {Them}?},\n\tvolume = {73},\n\tissn = {1536-4801},\n\tshorttitle = {Proton-{Pump} {Inhibitors}},\n\tdoi = {10.1097/MPG.0000000000003246},\n\tabstract = {The risk of bone fracture in children under proton-pump inhibitors (PPI) treatment has been the subject of recent publications and naturally raises concerns among prescribing doctors, patients and their parents.Currently, there is no consistency in those risk claims according to the available evidence and an update on it is beneficial to reduce anxiety on one hand, and prompt for well-planned studies addressing the issue on the other. Furthermore, common sense and well-founded prescriptions must be the general rule for this as for any other therapeutic drug.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Tavares, Marta and Amil-Dias, Jorge},\n\tmonth = dec,\n\tyear = {2021},\n\tpmid = {34310438},\n\tkeywords = {Child, Humans, Leg, Proton Pump Inhibitors},\n\tpages = {665--669},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Radiation burden in patients with esophageal atresia: a systematic review.\n \n \n \n\n\n \n Comella, A.; Tan Tanny, S. P.; Hutson, J. M.; Omari, T. I.; Teague, W. J.; Nataraja, R. M.; and King, S. K.\n\n\n \n\n\n\n Pediatric Surgery International, 37(7): 919–927. July 2021.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{comella_radiation_2021,\n\ttitle = {Radiation burden in patients with esophageal atresia: a systematic review},\n\tvolume = {37},\n\tissn = {1437-9813},\n\tshorttitle = {Radiation burden in patients with esophageal atresia},\n\tdoi = {10.1007/s00383-021-04892-4},\n\tabstract = {Esophageal atresia (EA) is the most common congenital esophageal disorder. Radiological imaging facilitates diagnosis, surgical interventions, and follow-up. Despite this, standardized monitoring guidelines are lacking. We aimed to: (1) review the literature regarding radiation burden in children with EA; (2) establish the presence of guidelines for diagnosis and follow-up in children with EA. The systematic review was performed according to PRISMA protocol. Two investigators conducted independent searches (PubMed, Ovid, Cochrane Review) and data extraction. Analysis focused on pre- and post-operative imaging type and frequency to determine the radiation burden. Seven studies met the inclusion criteria (337 patients). All authors agreed upon the need to minimize radiation burden, recommending symptoms-guided management, use of dosimeters, and non-radiating imaging. One study identified a median 130-fold increase in cumulative lifetime cancer risk in children with EA compared with other babies in the special care unit. The most common investigations were X-ray and CT (pre-operatively), and X-ray and contrast swallow (post-operatively). Standardized guidelines focused upon the frequency and type of radiological imaging for children with EA are lacking. Children with EA are subjected to more radiation exposure than the general population. Implementation of non-radiating imaging (ultrasonography, manometry) is recommended.},\n\tlanguage = {eng},\n\tnumber = {7},\n\tjournal = {Pediatric Surgery International},\n\tauthor = {Comella, Assia and Tan Tanny, Sharman P. and Hutson, John M. and Omari, Taher I. and Teague, Warwick J. and Nataraja, Ramesh M. and King, Sebastian K.},\n\tmonth = jul,\n\tyear = {2021},\n\tpmid = {33839909},\n\tkeywords = {Esophageal Atresia, Esophageal atresia, Esophagoplasty, Exposure, Humans, Infant, Manometry, Outcomes, Radiation, Radiation Exposure, Radiography, Systematic review},\n\tpages = {919--927},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Risk Factors and Reasons for Treatment Abandonment for Patients With Esophageal Atresia: A Study From a Tertiary Care Hospital in Beijing, China.\n \n \n \n\n\n \n Yang, S.; Liao, J.; Li, S.; Hua, K.; Wang, P.; Zhang, Y.; Zhao, Y.; Gu, Y.; Li, S.; and Huang, J.\n\n\n \n\n\n\n Frontiers in Pediatrics, 9: 634573. 2021.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{yang_risk_2021,\n\ttitle = {Risk {Factors} and {Reasons} for {Treatment} {Abandonment} for {Patients} {With} {Esophageal} {Atresia}: {A} {Study} {From} a {Tertiary} {Care} {Hospital} in {Beijing}, {China}},\n\tvolume = {9},\n\tissn = {2296-2360},\n\tshorttitle = {Risk {Factors} and {Reasons} for {Treatment} {Abandonment} for {Patients} {With} {Esophageal} {Atresia}},\n\tdoi = {10.3389/fped.2021.634573},\n\tabstract = {Background: This study aims to identify the risk factors and reasons for treatment abandonment for patients with esophageal atresia (EA) in a tertiary care hospital in China. Methods: A retrospective study was conducted on 360 patients with EA admitted to Beijing Children's Hospital between January 1, 2007 and June 1, 2020. Medical records for treatment abandonment and non-treatment abandonment patients were compared. Univariate and multivariate logistic regression analyses were conducted to identify potential risk factors for treatment abandonment. Results: After the diagnosis of EA, parents of 107 patients refused surgical repair and discharged against medical advice, and 253 patients underwent surgical repair. Among these 253 patients, parents of 59 patients abandoned treatment after surgery; 52 patients were discharged in an unstable condition, and parents of seven patients abandoned resuscitation leading to death in the hospital. By comparing clinical characteristics between treatment abandonment before surgery (n = 107) and non-treatment abandonment (n = 253) groups, we found that mother's parity {\\textgreater}1, unplanned admission to intensive care unit before surgery, associated anomalies, and Gross type A/B were significant independent risk factors for treatment abandonment before surgery. Furthermore, birth weight {\\textless}2,545 g, being discharged from neonatal center/intensive care unit and other departments, unplanned admission to intensive care unit after surgery, operative time {\\textgreater}133 min, admission before 2016, pneumothorax, and anastomotic leakage were significant independent risk factors for treatment abandonment after surgery. The reasons for treatment abandonment included financial difficulties, multiple malformations with poor prognosis, belief of incurability and concerns about the prognosis of the diseases, postoperative complications, and extensive length of intensive care unit stay. Conclusions: Treatment abandonment of children with EA/TEF is still a common and serious problem in China. This study showed that EA/TEF patients in critical conditions, with associated anomalies, Gross type A/B, and who had occurrence of complications had high-risk for treatment abandonment.},\n\tlanguage = {eng},\n\tjournal = {Frontiers in Pediatrics},\n\tauthor = {Yang, Shen and Liao, Junmin and Li, Siqi and Hua, Kaiyun and Wang, Peize and Zhang, Yanan and Zhao, Yong and Gu, Yichao and Li, Shuangshuang and Huang, Jinshi},\n\tyear = {2021},\n\tpmid = {33987150},\n\tpmcid = {PMC8112547},\n\tkeywords = {children, esophageal atresia, reasons, risk factors, treatment abandonment},\n\tpages = {634573},\n}\n\n\n\n\n\n\n\n

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\n Background: This study aims to identify the risk factors and reasons for treatment abandonment for patients with esophageal atresia (EA) in a tertiary care hospital in China. Methods: A retrospective study was conducted on 360 patients with EA admitted to Beijing Children's Hospital between January 1, 2007 and June 1, 2020. Medical records for treatment abandonment and non-treatment abandonment patients were compared. Univariate and multivariate logistic regression analyses were conducted to identify potential risk factors for treatment abandonment. Results: After the diagnosis of EA, parents of 107 patients refused surgical repair and discharged against medical advice, and 253 patients underwent surgical repair. Among these 253 patients, parents of 59 patients abandoned treatment after surgery; 52 patients were discharged in an unstable condition, and parents of seven patients abandoned resuscitation leading to death in the hospital. By comparing clinical characteristics between treatment abandonment before surgery (n = 107) and non-treatment abandonment (n = 253) groups, we found that mother's parity \\textgreater1, unplanned admission to intensive care unit before surgery, associated anomalies, and Gross type A/B were significant independent risk factors for treatment abandonment before surgery. Furthermore, birth weight \\textless2,545 g, being discharged from neonatal center/intensive care unit and other departments, unplanned admission to intensive care unit after surgery, operative time \\textgreater133 min, admission before 2016, pneumothorax, and anastomotic leakage were significant independent risk factors for treatment abandonment after surgery. The reasons for treatment abandonment included financial difficulties, multiple malformations with poor prognosis, belief of incurability and concerns about the prognosis of the diseases, postoperative complications, and extensive length of intensive care unit stay. Conclusions: Treatment abandonment of children with EA/TEF is still a common and serious problem in China. This study showed that EA/TEF patients in critical conditions, with associated anomalies, Gross type A/B, and who had occurrence of complications had high-risk for treatment abandonment.\n

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\n \n\n \n \n \n \n \n Exposure to air pollutants and risk of congenital anomalies: A systematic review and metaanalysis.\n \n \n \n\n\n \n Ravindra, K.; Chanana, N.; and Mor, S.\n\n\n \n\n\n\n The Science of the Total Environment, 765: 142772. April 2021.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{ravindra_exposure_2021,\n\ttitle = {Exposure to air pollutants and risk of congenital anomalies: {A} systematic review and metaanalysis},\n\tvolume = {765},\n\tissn = {1879-1026},\n\tshorttitle = {Exposure to air pollutants and risk of congenital anomalies},\n\tdoi = {10.1016/j.scitotenv.2020.142772},\n\tabstract = {BACKGROUND: Congenital malformations are considered as one of the significant causes of preterm as well as neonatal morbidity and mortality. Literature suggests the association of diverse congenital deformities with maternal exposure to air pollutants. However, the evidence is still inconclusive on the manifestation of these during pregnancy. Thus, systematic review was done on the available epidemiological studies studying the effect of air pollutants on congenital malformations. Furthermore, the meta-analysis was conducted for several combinations of air pollutants and congenital defects.\nMETHODS: Twenty six epidemiological studies were extracted from the databases and examined for association of risk of congenital defects with air pollutant concentrations. Metaanalysis was done if the risk estimates of the same anomaly and pollutant group were reported in at least three studies.\nRESULTS: Each study reported a statistically significant increased risk of congenital malformation with some air pollutant, amid the several tested combinations. Our meta-analysis reported that nitrogen dioxide and PM2.5 were associated with the risk of pulmonary valve stenosis with OR = 1.74 and OR = 1.42 respectively. The risk of developing tetralogy of Fallot (TOF) was observed to be associated with PM2.5 with OR = 1.52. SO2 exposure was related to a high risk of the ventricular septal defect (VSD) with OR = 1.15 and orofacial defects (OR = 1.27).\nCONCLUSION: It is evidenced that ambient air pollutants have some effect on congenital malformations. Standard case definitions, improved methods of exposure, and better control of confounders will improve future research in this area.},\n\tlanguage = {eng},\n\tjournal = {The Science of the Total Environment},\n\tauthor = {Ravindra, Khaiwal and Chanana, Neha and Mor, Suman},\n\tmonth = apr,\n\tyear = {2021},\n\tpmid = {33183823},\n\tkeywords = {Air Pollutants, Air Pollution, Birth defects, Congenital Abnormalities, Congenital anomalies, Congenital malformations, Databases, Factual, Environmental Pollutants, Female, Humans, Infant, Newborn, Maternal Exposure, Meta-analysis, Nitrogen Dioxide, Particulate Matter, Pregnancy},\n\tpages = {142772},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n ERNICA Consensus Conference on the Management of Patients with Long-Gap Esophageal Atresia: Perioperative, Surgical, and Long-Term Management.\n \n \n \n \n\n\n \n Dingemann, C.; Eaton, S.; Aksnes, G.; Bagolan, P.; Cross, K. M.; De Coppi, P.; Fruithof, J.; Gamba, P.; Goldschmidt, I.; Gottrand, F.; Pirr, S.; Rasmussen, L.; Sfeir, R.; Slater, G.; Suominen, J.; Svensson, J. F.; Thorup, J. M.; Tytgat, S. H. A. J.; van der Zee, D. C.; Wessel, L.; Widenmann-Grolig, A.; Wijnen, R.; Zetterquist, W.; and Ure, B. M.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 31(3): 214–225. June 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"ERNICA$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{dingemann_ernica_2021,\n\ttitle = {{ERNICA} {Consensus} {Conference} on the {Management} of {Patients} with {Long}-{Gap} {Esophageal} {Atresia}: {Perioperative}, {Surgical}, and {Long}-{Term} {Management}},\n\tvolume = {31},\n\tissn = {1439-359X},\n\tshorttitle = {{ERNICA} {Consensus} {Conference} on the {Management} of {Patients} with {Long}-{Gap} {Esophageal} {Atresia}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/32668485/},\n\tdoi = {10.1055/s-0040-1713932},\n\tabstract = {INTRODUCTION: Evidence supporting best practice for long-gap esophageal atresia is limited. The European Reference Network for Rare Inherited Congenital Anomalies (ERNICA) organized a consensus conference on the management of patients with long-gap esophageal atresia based on expert opinion referring to the latest literature aiming to provide clear and uniform statements in this respect.\nMATERIALS AND METHODS: Twenty-four ERNICA representatives from nine European countries participated. The conference was prepared by item generation, item prioritization by online survey, formulation of a final list containing items on perioperative, surgical, and long-term management, and literature review. The 2-day conference was held in Berlin in November 2019. Anonymous voting was conducted via an internet-based system using a 1 to 9 scale. Consensus was defined as ≥75\\% of those voting scoring 6 to 9.\nRESULTS: Ninety-seven items were generated. Complete consensus (100\\%) was achieved on 56 items (58\\%), e.g., avoidance of a cervical esophagostomy, promotion of sham feeding, details of delayed anastomosis, thoracoscopic pouch mobilization and placement of traction sutures as novel technique, replacement techniques, and follow-up. Consensus ≥75\\% was achieved on 90 items (93\\%), e.g., definition of long gap, routine pyloroplasty in gastric transposition, and avoidance of preoperative bougienage to enable delayed anastomosis. Nineteen items (20\\%), e.g., methods of gap measurement were discussed controversially (range 1-9).\nCONCLUSION: This is the first consensus conference on the perioperative, surgical, and long-term management of patients with long-gap esophageal atresia. Substantial statements regarding esophageal reconstruction or replacement and follow-up were formulated which may contribute to improve patient care.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Dingemann, Carmen and Eaton, Simon and Aksnes, Gunnar and Bagolan, Pietro and Cross, Kate M. and De Coppi, Paolo and Fruithof, JoAnne and Gamba, Piergiorgio and Goldschmidt, Imeke and Gottrand, Frederic and Pirr, Sabine and Rasmussen, Lars and Sfeir, Rony and Slater, Graham and Suominen, Janne and Svensson, Jan F. and Thorup, Joergen M. and Tytgat, Stefaan H. A. J. and van der Zee, David C. and Wessel, Lucas and Widenmann-Grolig, Anke and Wijnen, René and Zetterquist, Wilhelm and Ure, Benno M.},\n\tmonth = jun,\n\tyear = {2021},\n\tpmid = {32668485},\n\tkeywords = {Aftercare, Esophageal Atresia, Esophagoplasty, Humans, Infant, Newborn, Perioperative Care, Treatment Outcome},\n\tpages = {214--225},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Risk Factors of Early Mortality and Morbidity in Esophageal Atresia with Distal Tracheoesophageal Fistula: A Population-Based Cohort Study.\n \n \n \n \n\n\n \n Sfeir, R.; Rousseau, V.; Bonnard, A.; Gelas, T.; Aumar, M.; Panait, N.; Piolat, C.; Irtan, S.; Fouquet, V.; Lemandat, A.; De Napoli, S.; Habonimana, E.; Lamireau, T.; Lemelle, J. L.; El Baz, F.; Talon, I.; Polimerol, M. L.; Allal, H.; Buisson, P.; Petit, T.; Louis, D.; Lardy, H.; Schmitt, F.; Levard, G.; Scalabre, A.; Michel, J. L.; Jaby, O.; Pelatan, C.; De Vries, P.; Borderon, C.; Fourcade, L.; Breaud, J.; Pouzac, M.; Tolg, C.; Chaussy, Y.; Ritz, S. J.; Laplace, C.; Drumez, E.; and Gottrand, F.\n\n\n \n\n\n\n The Journal of Pediatrics, 234: 99–105.e1. July 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"Risk$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{sfeir_risk_2021,\n\ttitle = {Risk {Factors} of {Early} {Mortality} and {Morbidity} in {Esophageal} {Atresia} with {Distal} {Tracheoesophageal} {Fistula}: {A} {Population}-{Based} {Cohort} {Study}},\n\tvolume = {234},\n\tissn = {1097-6833},\n\tshorttitle = {Risk {Factors} of {Early} {Mortality} and {Morbidity} in {Esophageal} {Atresia} with {Distal} {Tracheoesophageal} {Fistula}},\n\turl = {http://hdl.handle.net/20.500.12210/40495},\n\tdoi = {10.1016/j.jpeds.2021.02.064},\n\tabstract = {OBJECTIVE: To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula.\nSTUDY DESIGN: Cohort study from a national register. Main outcomes and measures included early mortality, hospital length of stay (LoS), need for nutritional support at 1 year of age as a proxy measure of morbidity, and complications during the first year of life.\nRESULTS: In total, 1008 patients with a lower esophageal fistula were included from January 1, 2008, to December 31, 2014. The survival rate at 3 months was 94.9\\%. The cumulative hospital LoS was 31.0 (17.0-64.0) days. Multivariate analysis showed that intrahospital mortality at 3 months was associated with low birth weight (OR 0.52, 95\\% CI [0.38-0.72], P {\\textless} .001), associated cardiac abnormalities (OR 6.09 [1.96-18.89], P = .002), and prenatal diagnosis (OR 2.96 [1.08-8.08], P = .034). LoS was associated with low birth weight (-0.225 ± 0.035, P {\\textless} .001), associated malformations (0.082 ± 0.118, P {\\textless} .001), surgical difficulties (0.270 ± 0.107, P {\\textless} .001), and complications (0.535 ± 0.099, P {\\textless} .001) during the first year of life. Predictive factors for dependency on nutrition support at 1 year of age were complications before 1 year (OR 3.28 [1.23-8.76], P {\\textless} .02) and initial hospital LoS (OR 1.96 [1.15-3.33], P {\\textless} .01).\nCONCLUSIONS: EA has a low rate of early mortality, but morbidity is high during the first year of life. Identifying factors associated with morbidity may help to improve neonatal care of this population.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Sfeir, Rony and Rousseau, Veronique and Bonnard, Arnaud and Gelas, Thomas and Aumar, Madeleine and Panait, Nicoleta and Piolat, Christian and Irtan, Sabine and Fouquet, Virginie and Lemandat, Aurelie and De Napoli, Stephan and Habonimana, Edouard and Lamireau, Thierry and Lemelle, Jean Louis and El Baz, Frederic and Talon, Isabelle and Polimerol, Marie Laurence and Allal, Hussein and Buisson, Philippe and Petit, Thierry and Louis, David and Lardy, Hubert and Schmitt, Francoise and Levard, Guillaume and Scalabre, Aurélien and Michel, Jean Luc and Jaby, Olivier and Pelatan, Cecile and De Vries, Philine and Borderon, Corinne and Fourcade, Laurent and Breaud, Jean and Pouzac, Myriam and Tolg, Cecilia and Chaussy, Yann and Ritz, Sandy Jochault and Laplace, Christophe and Drumez, Elodie and Gottrand, Frederic},\n\tmonth = jul,\n\tyear = {2021},\n\tpmid = {33667507},\n\tkeywords = {Esophageal Atresia, Female, France, Heart Defects, Congenital, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Length of Stay, Male, Nutritional Support, Prenatal Diagnosis, Registries, Risk Factors, Surveys and Questionnaires, Tracheoesophageal Fistula, congenital abnormalities, population-based registry, prenatal diagnosis},\n\tpages = {99--105.e1},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Prevalence of and Risk Factors for Sagittal Posture Abnormalities in Children Born With Esophageal Atresia: A Prospective Cohort Study.\n \n \n \n \n\n\n \n Bisson, B.; Gottrand, L.; Aumar, M.; Nicolas, A.; Sfeir, R.; Labreuche, J.; Thevenon, A.; and Gottrand, F.\n\n\n \n\n\n\n Frontiers in Pediatrics, 9: 762078. 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"Prevalence$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{bisson_prevalence_2021,\n\ttitle = {Prevalence of and {Risk} {Factors} for {Sagittal} {Posture} {Abnormalities} in {Children} {Born} {With} {Esophageal} {Atresia}: {A} {Prospective} {Cohort} {Study}},\n\tvolume = {9},\n\tissn = {2296-2360},\n\tshorttitle = {Prevalence of and {Risk} {Factors} for {Sagittal} {Posture} {Abnormalities} in {Children} {Born} {With} {Esophageal} {Atresia}},\n\turl = {http://hdl.handle.net/20.500.12210/60425},\n\tdoi = {10.3389/fped.2021.762078},\n\tabstract = {Introduction: Scoliosis is a well-described complication of esophageal atresia (EA) caused by the associated spine malformations and/or thoracotomy. However, the sagittal posture abnormalities in patients with EA have not been described. The aim of this study was to evaluate the prevalence of and risk factors for sagittal posture abnormalities at the age of 6 years in patients operated on for EA. Methods: A prospective cohort of 123 patients with EA was examined by the same rehabilitation doctor at the time of a multidisciplinary visit scheduled at the age of 6 years. Children presenting with scoliosis (n = 4) or who missed the consultation (n = 33) were excluded. Univariate and multivariate logistic regression models with Firth's penalized-likelihood approach were used to identify risk factors associated with sagittal posture anomalies. Candidate risk factors included neonatal characteristics, associated malformations, atresia type, postoperative complications, psychomotor development retardation, orthopedic abnormalities, and neurological hypotonia. Results: The prevalence rates of sagittal posture abnormalities were 25.6\\% (n = 22; 95\\% CI, 16.7-36.1\\%). Multivariate analysis showed that minor orthopedic abnormalities (OR: 4.02, 95\\% CI: 1.29-13.43, P = 0.021), and VACTERL (OR: 3.35, 95\\% CI: 1.09-10.71, P = 0.042) were significant risk factors for sagittal posture abnormalities. Conclusion: This study shows that sagittal posture anomalies occur frequently in children operated on at birth for EA and are not directly linked to the surgical repair. These children should be screened and treated using postural physiotherapy, especially those with VACTERL and minor orthopedic abnormalities.},\n\tlanguage = {eng},\n\tjournal = {Frontiers in Pediatrics},\n\tauthor = {Bisson, Benoit and Gottrand, Laurence and Aumar, Madeleine and Nicolas, Audrey and Sfeir, Rony and Labreuche, Julien and Thevenon, André and Gottrand, Frederic},\n\tyear = {2021},\n\tpmid = {34900868},\n\tpmcid = {PMC8656431},\n\tkeywords = {VACTERL, children, esophageal atresia, kyphosis, sagittal postural patterns},\n\tpages = {762078},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Percutaneous Endoscopic Gastrostomy in Children: An Update to the ESPGHAN Position Paper.\n \n \n \n \n\n\n \n Homan, M.; Hauser, B.; Romano, C.; Tzivinikos, C.; Torroni, F.; Gottrand, F.; Hojsak, I.; Dall'Oglio, L.; Thomson, M.; Bontems, P.; Narula, P.; Furlano, R.; Oliva, S.; and Amil-Dias, J.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 73(3): 415–426. September 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"Percutaneous$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{homan_percutaneous_2021,\n\ttitle = {Percutaneous {Endoscopic} {Gastrostomy} in {Children}: {An} {Update} to the {ESPGHAN} {Position} {Paper}},\n\tvolume = {73},\n\tissn = {1536-4801},\n\tshorttitle = {Percutaneous {Endoscopic} {Gastrostomy} in {Children}},\n\turl = {https://lilloa.univ-lille.fr/handle/20.500.12210/101121},\n\tdoi = {10.1097/MPG.0000000000003207},\n\tabstract = {BACKGROUND: The European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) position paper from 2015 on percutaneous endoscopic gastrostomy (PEG) required updating in the light of recent clinical knowledge and data published in medical journals since 2014.\nMETHODS: A systematic review of medical literature from 2014 to 2020 was carried out. Consensus on the content of the manuscript, including recommendations, was achieved by the authors through electronic and virtual means. The expert opinion of the authors is also expressed in the manuscript when there was a lack of good scientific evidence regarding PEGs in children in the literature.\nRESULTS: The authors recommend that the indication for a PEG be individualized, and that the decision for PEG insertion is arrived at by a multidisciplinary team (MDT) having considered all appropriate circumstances. Well timed enteral nutrition is optimal to treat faltering growth to avoid complications of malnutrition and body composition. Timing, device choice and method of insertion is dependent on the local expertise and after due consideration with the MDT and family. Major complications such as inadvertent bowel perforation should be avoided by attention to good technique and by ensuring the appropriate experience of the operating team. Feeding can be initiated as early as 3 hours after tube placement in a stable child with iso-osmolar feeds of standard polymeric formula. Low-profile devices can be inserted initially using the single-stage procedure or after 2-3 months by replacing a standard PEG tube, in those requiring longer-term feeding. Having had a period of non-use and reliance upon oral intake for growth and weight gain-typically 8-12 weeks-a PEG may then safely be removed after due consultation. In the event of non-closure of the fistula the most successful method for closing it, to date, has been a surgical procedure, but the Over-The-Scope-Clip (OTSC) has recently been used with considerable success in this scenario.\nCONCLUSIONS: A multidisciplinary approach is mandatory for the best possible treatment of children with PEGs. Morbidity and mortality are minimized through team decisions on indications for insertion, adequate planning and preparation before the procedure, subsequent monitoring of patients, timing of the change to low-profile devices, management of any complications, and optimal timing of removal of the PEG.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Homan, Matjaž and Hauser, Bruno and Romano, Claudio and Tzivinikos, Christos and Torroni, Filippo and Gottrand, Frédéric and Hojsak, Iva and Dall'Oglio, Luigi and Thomson, Mike and Bontems, Patrick and Narula, Priya and Furlano, Raoul and Oliva, Salvatore and Amil-Dias, Jorge},\n\tmonth = sep,\n\tyear = {2021},\n\tpmid = {34155150},\n\tkeywords = {Child, Child Nutritional Physiological Phenomena, Enteral Nutrition, Gastroenterology, Gastrostomy, Humans, Nutritional Status},\n\tpages = {415--426},\n}\n\n\n\n

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\n BACKGROUND: The European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) position paper from 2015 on percutaneous endoscopic gastrostomy (PEG) required updating in the light of recent clinical knowledge and data published in medical journals since 2014. METHODS: A systematic review of medical literature from 2014 to 2020 was carried out. Consensus on the content of the manuscript, including recommendations, was achieved by the authors through electronic and virtual means. The expert opinion of the authors is also expressed in the manuscript when there was a lack of good scientific evidence regarding PEGs in children in the literature. RESULTS: The authors recommend that the indication for a PEG be individualized, and that the decision for PEG insertion is arrived at by a multidisciplinary team (MDT) having considered all appropriate circumstances. Well timed enteral nutrition is optimal to treat faltering growth to avoid complications of malnutrition and body composition. Timing, device choice and method of insertion is dependent on the local expertise and after due consideration with the MDT and family. Major complications such as inadvertent bowel perforation should be avoided by attention to good technique and by ensuring the appropriate experience of the operating team. Feeding can be initiated as early as 3 hours after tube placement in a stable child with iso-osmolar feeds of standard polymeric formula. Low-profile devices can be inserted initially using the single-stage procedure or after 2-3 months by replacing a standard PEG tube, in those requiring longer-term feeding. Having had a period of non-use and reliance upon oral intake for growth and weight gain-typically 8-12 weeks-a PEG may then safely be removed after due consultation. In the event of non-closure of the fistula the most successful method for closing it, to date, has been a surgical procedure, but the Over-The-Scope-Clip (OTSC) has recently been used with considerable success in this scenario. CONCLUSIONS: A multidisciplinary approach is mandatory for the best possible treatment of children with PEGs. Morbidity and mortality are minimized through team decisions on indications for insertion, adequate planning and preparation before the procedure, subsequent monitoring of patients, timing of the change to low-profile devices, management of any complications, and optimal timing of removal of the PEG.\n

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\n \n\n \n \n \n \n \n \n Factors Associated With Success and Failure of Weaning Children From Prolonged Enteral Nutrition: A Retrospective Cohort Study.\n \n \n \n \n\n\n \n Dipasquale, V.; Lecoeur, K.; Aumar, M.; Guimber, D.; Coopman, S.; Nicolas, A.; Turck, D.; Gottrand, F.; and Ley, D.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 72(1): 135–140. January 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"Factors$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{dipasquale_factors_2021,\n\ttitle = {Factors {Associated} {With} {Success} and {Failure} of {Weaning} {Children} {From} {Prolonged} {Enteral} {Nutrition}: {A} {Retrospective} {Cohort} {Study}},\n\tvolume = {72},\n\tissn = {1536-4801},\n\tshorttitle = {Factors {Associated} {With} {Success} and {Failure} of {Weaning} {Children} {From} {Prolonged} {Enteral} {Nutrition}},\n\turl = {https://lilloa.univ-lille.fr/handle/20.500.12210/40784},\n\tdoi = {10.1097/MPG.0000000000002909},\n\tabstract = {OBJECTIVES: The aims of the present study were to assess the efficacy of a tube weaning program, and to identify factors associated with success and failure.\nMETHODS: This was a retrospective cohort study including all pediatric patients on enteral nutrition (EN) for ≥6 months for whom at least 1 attempt of weaning was performed in a single tertiary referral center from 2012 to 2017, with a minimum follow-up of 6 months after EN discontinuation. Weaning program was individualized to each child. Weaning success was defined a priori. Factors associated with success were investigated using multivariate analysis.\nRESULTS: Ninety-four patients were enrolled, in whom a total of 114 attempts of weaning were performed at a median age of 51 ± 40 months. Success was achieved in 80 attempts (success rate of 70\\%). One hundred three (92\\%) weaning attempts were performed at home with a follow-up in the outpatient clinic, mostly (74\\%) by a progressive ({\\textgreater}1 month) reduction of tube feeding. Patients who required psychological support during weaning had more failures than patients who did not (odds ratio = 5.7, 95\\% confidence interval [1.2-27.0], P = 0.03). The presence of impaired oral feeding skills at the time of EN discontinuation was also predictive of failure (odds ratio = 6.2, 95\\% confidence interval [0.05-0.5], P = 0.005).\nCONCLUSIONS: Our progressive, mostly outpatient-based, patient-tailored program of weaning from EN is effective for tube-dependent children. Children who need psychological support during weaning and those who present impaired oral feeding skills represent a subgroup of at-risk patients for whom alternative weaning strategies may need to be considered.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Dipasquale, Valeria and Lecoeur, Katia and Aumar, Madeleine and Guimber, Dominique and Coopman, Stéphanie and Nicolas, Audrey and Turck, Dominique and Gottrand, Frédéric and Ley, Delphine},\n\tmonth = jan,\n\tyear = {2021},\n\tpmid = {32810034},\n\tkeywords = {Child, Child, Preschool, Enteral Nutrition, Feeding Behavior, Humans, Infant, Retrospective Studies, Tertiary Care Centers, Weaning},\n\tpages = {135--140},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Clinician Knowledge of Societal Guidelines on Management of Gastrointestinal Complications in Esophageal Atresia.\n \n \n \n \n\n\n \n O'Donnell, J. E. M.; Purcell, M.; Mousa, H.; Dall'Oglio, L.; Rosen, R.; Faure, C.; Gottrand, F.; and Krishnan, U.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 72(2): 232–238. February 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"Clinician$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{odonnell_clinician_2021,\n\ttitle = {Clinician {Knowledge} of {Societal} {Guidelines} on {Management} of {Gastrointestinal} {Complications} in {Esophageal} {Atresia}},\n\tvolume = {72},\n\tissn = {1536-4801},\n\turl = {http://hdl.handle.net/20.500.12210/40560},\n\tdoi = {10.1097/MPG.0000000000002945},\n\tabstract = {OBJECTIVES: The aim of this study was to assess whether clinicians approached the management of children with esophageal atresia (EA) in accordance with the 2016 European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society of Paediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines on the management of gastrointestinal and nutritional complications in this cohort.\nMETHODS: We invited expert physicians and surgeons closely involved in the care of children with EA (members of the International network on esophageal atresia [INoEA], ESPGHAN EA working group, French national EA registry, European pediatric surgical association (EUPSA), and European rare disease reference network [ERNICA]) to participate in an anonymous online survey containing 15 multiple choice questions concerning the management of gastrointestinal and nutritional complications in children with EA. Questions were based on the management of gastroesophageal reflux disease (GERD) dysphagia, cyanotic spells, feeding and nutrition, anastamotic strictures, and transition to adult care as detailed in the 2016 guidelines.\nRESULTS: Median concordance with ESPGHAN/NASPHAN EA Guidelines was 69\\% (16-100\\%, SD 16\\%) across all responders. Areas of greatest concordance were in the fields of surveillance endoscopy and medical management of GERD. Areas for potential educational opportunities include: the differential diagnosis and appropriate investigation of dysphagia and the diagnostic evaluation of extraesophageal symptoms.\nCONCLUSIONS: This survey highlights the importance of improving the understanding and adherence to the EA guidelines amongst clinicians involved in the care of these patients.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {O'Donnell, Jonathan E. M. and Purcell, Michael and Mousa, Hayat and Dall'Oglio, Luigi and Rosen, Rachel and Faure, Christophe and Gottrand, Frédéric and Krishnan, Usha},\n\tmonth = feb,\n\tyear = {2021},\n\tpmid = {32932384},\n\tkeywords = {Adult, Child, Deglutition Disorders, Esophageal Atresia, Gastroenterology, Gastroesophageal Reflux, Humans, Surveys and Questionnaires},\n\tpages = {232--238},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n An international survey on anastomotic stricture management after esophageal atresia repair: considerations and advisory statements.\n \n \n \n \n\n\n \n Ten Kate, C. A.; Tambucci, R.; Vlot, J.; Spaander, M. C. W.; Gottrand, F.; Wijnen, R. M. H.; and Dall'Oglio, L.\n\n\n \n\n\n\n Surgical Endoscopy, 35(7): 3653–3661. July 2021.\n \n\n\n\n
\n\n\n\n \n \n $\"An$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{ten_kate_international_2021,\n\ttitle = {An international survey on anastomotic stricture management after esophageal atresia repair: considerations and advisory statements},\n\tvolume = {35},\n\tissn = {1432-2218},\n\tshorttitle = {An international survey on anastomotic stricture management after esophageal atresia repair},\n\turl = {http://hdl.handle.net/20.500.12210/40714},\n\tdoi = {10.1007/s00464-020-07844-6},\n\tabstract = {BACKGROUND: Endoscopic dilatation is the first-line treatment of stricture formation after esophageal atresia (EA) repair. However, there is no consensus on how to perform these dilatation procedures which may lead to a large variation between centers, countries and doctor's experience. This is the first cross-sectional study to provide an overview on differences in endoscopic dilatation treatment of pediatric anastomotic strictures worldwide.\nMETHODS: An online questionnaire was sent to members of five pediatric medical networks, experienced in treating anastomotic strictures in children with EA. The main outcome was the difference in endoscopic dilatation procedures in various centers worldwide, including technical details, dilatation approach (routine or only in symptomatic patients), and adjuvant treatment options. Descriptive statistics were performed with SPSS.\nRESULTS: Responses from 115 centers from 32 countries worldwide were analyzed. The preferred approach was balloon dilatation (68\\%) with a guidewire (66\\%), performed by a pediatric gastroenterologist (n = 103) or pediatric surgeon (n = 48) in symptomatic patients (68\\%). In most centers, hydrostatic pressure was used for balloon dilatation. The insufflation duration was standardized in 59 centers with a median duration of 60 (range 5-300) seconds. The preferred first-line adjunctive treatments in case of recurrent strictures were intralesional steroids and topical mitomycin C, in respectively 47\\% and 31\\% of the centers.\nCONCLUSIONS: We found a large variation in stricture management in children with EA, which confirms the current lack of consensus. International networks for rare diseases are required for harmonizing and comparing the procedures, for which we give several suggestions.},\n\tlanguage = {eng},\n\tnumber = {7},\n\tjournal = {Surgical Endoscopy},\n\tauthor = {Ten Kate, Chantal A. and Tambucci, Renato and Vlot, John and Spaander, Manon C. W. and Gottrand, Frederic and Wijnen, Rene M. H. and Dall'Oglio, Luigi},\n\tmonth = jul,\n\tyear = {2021},\n\tpmid = {32748272},\n\tpmcid = {PMC8195894},\n\tkeywords = {Anastomotic strictures, Child, Constriction, Pathologic, Cross-Sectional Studies, Dilatation, Dilatation management, Esophageal Atresia, Esophageal Stenosis, Esophageal atresia, Humans, Postoperative Complications, Retrospective Studies, Surveys and Questionnaires, Treatment Outcome},\n\tpages = {3653--3661},\n}\n\n\n\n

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\n \n 2020\n \n \n (8)\n \n \n

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\n \n\n \n \n \n \n \n \n Esophageal perforation in eosinophilic esophagitis: five cases in children.\n \n \n \n \n\n\n \n Donnet, C.; Destombe, S.; Lachaux, A.; Michaud, L.; Triolo, V.; Heissat, S.; Stephan, J.; and Patural, H.\n\n\n \n\n\n\n Endoscopy International Open, 8(7): E830–E833. July 2020.\n \n\n\n\n
\n\n\n\n \n \n $\"Esophageal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@article{donnet_esophageal_2020,\n\ttitle = {Esophageal perforation in eosinophilic esophagitis: five cases in children},\n\tvolume = {8},\n\tissn = {2364-3722},\n\tshorttitle = {Esophageal perforation in eosinophilic esophagitis},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/32617387/},\n\tdoi = {10.1055/a-0914-2711},\n\tabstract = {Background and study aims  Eosinophilic esophagitis (EoE) is a chronic immune disease with increasing incidence. It is clinically defined by symptoms of esophageal dysfunction and histologically by eosinophilic polynuclear cell infiltration of the esophageal mucosa. Symptoms are not specific and include gastroesophageal reflux disease (GERD), dysphagia, vomiting or dietary blockages. Chronic inflammation of the mucosa may lead to narrowing of the esophageal lumen responsible for impactions. Extraction procedures can be complicated by dissection and perforation. Rare spontaneous ruptures of the esophagus known as Boerhaave syndrome are also possible. We report five cases of esophageal perforation in children with EoE, three with spontaneous rupture and two after an endoscopic procedure. The evolution was favorable under medical treatment.},\n\tlanguage = {eng},\n\tnumber = {7},\n\tjournal = {Endoscopy International Open},\n\tauthor = {Donnet, Camille and Destombe, Sylvie and Lachaux, Alain and Michaud, Laurent and Triolo, Valérie and Heissat, Sophie and Stephan, Jean-Louis and Patural, Hugues},\n\tmonth = jul,\n\tyear = {2020},\n\tpmid = {32617387},\n\tpmcid = {PMC7297612},\n\tpages = {E830--E833},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Bronchopulmonary and vascular anomalies are frequent in children with oesophageal atresia.\n \n \n \n \n\n\n \n Lejeune, S.; Le Mee, A.; Petyt, L.; Hutt, A.; Sfeir, R.; Michaud, L.; Fayoux, P.; Deschildre, A.; Gottrand, F.; and Thumerelle, C.\n\n\n \n\n\n\n Acta Paediatrica (Oslo, Norway: 1992), 109(6): 1221–1228. June 2020.\n \n\n\n\n
\n\n\n\n \n \n $\"Bronchopulmonary$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{lejeune_bronchopulmonary_2020,\n\ttitle = {Bronchopulmonary and vascular anomalies are frequent in children with oesophageal atresia},\n\tvolume = {109},\n\tissn = {1651-2227},\n\turl = {http://hdl.handle.net/20.500.12210/79209},\n\tdoi = {10.1111/apa.15086},\n\tabstract = {AIM: Oesophageal atresia is frequently associated with other malformations, and our aim was to use computed tomography (CT) to explore intrathoracic malformations in patients with this condition.\nMETHOD: This was retrospective study of children aged 0-16 with oesophageal atresia who were born in 1996-2013 and followed up at the French reference centre for rare oesophageal diseases at the University of Lille. Computed tomography scans were available for 48 of the 234 patients during follow-up visits, and these were reviewed by a thoracic radiologist.\nRESULTS: More than two-thirds of the scans were performed to explore persistent respiratory symptoms. We found that six patients had a pulmonary malformations: four lobar agenesis, one right pulmonary aplasia and one congenital cystic adenomatoid malformation. Computed tomography enabled us to diagnose unexpected thoracic malformations in 16 patients: four lobar agenesis, six arteria lusoria, five persistent left superior vena cava and one partial anomalous pulmonary venous return. It also confirmed the diagnoses of suspected malformations in five patients: one congenital cystic adenomatoid malformation, one pulmonary hypoplasia, two right-sided aortic arches and one communicating bronchopulmonary foregut malformation.\nCONCLUSION: Intrathoracic anomalies were frequently associated with oesophageal atresia, and contrast-enhanced chest CT scans should be performed on patients with persistent respiratory symptoms.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Acta Paediatrica (Oslo, Norway: 1992)},\n\tauthor = {Lejeune, Stephanie and Le Mee, Armelle and Petyt, Laurent and Hutt, Antoine and Sfeir, Rony and Michaud, Laurent and Fayoux, Pierre and Deschildre, Antoine and Gottrand, Frederic and Thumerelle, Caroline},\n\tmonth = jun,\n\tyear = {2020},\n\tpmid = {31710383},\n\tkeywords = {Adolescent, Adult, Child, Child, Preschool, Cystic Adenomatoid Malformation of Lung, Congenital, Esophageal Atresia, Humans, Infant, Infant, Newborn, Lung, Retrospective Studies, Vena Cava, Superior, computed tomography, congenital malformations, diagnostic imaging, oesophageal atresia, thoracic malformations},\n\tpages = {1221--1228},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Long-term survival of children born with congenital anomalies: A systematic review and meta-analysis of population-based studies.\n \n \n \n\n\n \n Glinianaia, S. V.; Morris, J. K.; Best, K. E.; Santoro, M.; Coi, A.; Armaroli, A.; and Rankin, J.\n\n\n \n\n\n\n PLoS medicine, 17(9): e1003356. September 2020.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{glinianaia_long-term_2020,\n\ttitle = {Long-term survival of children born with congenital anomalies: {A} systematic review and meta-analysis of population-based studies},\n\tvolume = {17},\n\tissn = {1549-1676},\n\tshorttitle = {Long-term survival of children born with congenital anomalies},\n\tdoi = {10.1371/journal.pmed.1003356},\n\tabstract = {BACKGROUND: Following a reduction in global child mortality due to communicable diseases, the relative contribution of congenital anomalies to child mortality is increasing. Although infant survival of children born with congenital anomalies has improved for many anomaly types in recent decades, there is less evidence on survival beyond infancy. We aimed to systematically review, summarise, and quantify the existing population-based data on long-term survival of individuals born with specific major congenital anomalies and examine the factors associated with survival.\nMETHODS AND FINDINGS: Seven electronic databases (Medline, Embase, Scopus, PsycINFO, CINAHL, ProQuest Natural, and Biological Science Collections), reference lists, and citations of the included articles for studies published 1 January 1995 to 30 April 2020 were searched. Screening for eligibility, data extraction, and quality appraisal were performed in duplicate. We included original population-based studies that reported long-term survival (beyond 1 year of life) of children born with a major congenital anomaly with the follow-up starting from birth that were published in the English language as peer-reviewed papers. Studies on congenital heart defects (CHDs) were excluded because of a recent systematic review of population-based studies of CHD survival. Meta-analysis was performed to pool survival estimates, accounting for trends over time. Of 10,888 identified articles, 55 (n = 367,801 live births) met the inclusion criteria and were summarised narratively, 41 studies (n = 54,676) investigating eight congenital anomaly types (spina bifida [n = 7,422], encephalocele [n = 1,562], oesophageal atresia [n = 6,303], biliary atresia [n = 3,877], diaphragmatic hernia [n = 6,176], gastroschisis [n = 4,845], Down syndrome by presence of CHD [n = 22,317], and trisomy 18 [n = 2,174]) were included in the meta-analysis. These studies covered birth years from 1970 to 2015. Survival for children with spina bifida, oesophageal atresia, biliary atresia, diaphragmatic hernia, gastroschisis, and Down syndrome with an associated CHD has significantly improved over time, with the pooled odds ratios (ORs) of surviving per 10-year increase in birth year being OR = 1.34 (95\\% confidence interval [95\\% CI] 1.24-1.46), OR = 1.50 (95\\% CI 1.38-1.62), OR = 1.62 (95\\% CI 1.28-2.05), OR = 1.57 (95\\% CI 1.37-1.81), OR = 1.24 (95\\% CI 1.02-1.5), and OR = 1.99 (95\\% CI 1.67-2.37), respectively (p {\\textless} 0.001 for all, except for gastroschisis [p = 0.029]). There was no observed improvement for children with encephalocele (OR = 0.98, 95\\% CI 0.95-1.01, p = 0.19) and children with biliary atresia surviving with native liver (OR = 0.96, 95\\% CI 0.88-1.03, p = 0.26). The presence of additional structural anomalies, low birth weight, and earlier year of birth were the most commonly reported predictors of reduced survival for any congenital anomaly type. The main limitation of the meta-analysis was the small number of studies and the small size of the cohorts, which limited the predictive capabilities of the models resulting in wide confidence intervals.\nCONCLUSIONS: This systematic review and meta-analysis summarises estimates of long-term survival associated with major congenital anomalies. We report a significant improvement in survival of children with specific congenital anomalies over the last few decades and predict survival estimates up to 20 years of age for those born in 2020. This information is important for the planning and delivery of specialised medical, social, and education services and for counselling affected families. This trial was registered on the PROSPERO database (CRD42017074675).},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {PLoS medicine},\n\tauthor = {Glinianaia, Svetlana V. and Morris, Joan K. and Best, Kate E. and Santoro, Michele and Coi, Alessio and Armaroli, Annarita and Rankin, Judith},\n\tmonth = sep,\n\tyear = {2020},\n\tpmid = {32986711},\n\tpmcid = {PMC7521740},\n\tkeywords = {Adult, Age Factors, Child, Child Mortality, Child, Preschool, Congenital Abnormalities, Female, Humans, Infant, Live Birth, Parturition, Pregnancy, Registries, Young Adult},\n\tpages = {e1003356},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n BACKGROUND: Following a reduction in global child mortality due to communicable diseases, the relative contribution of congenital anomalies to child mortality is increasing. Although infant survival of children born with congenital anomalies has improved for many anomaly types in recent decades, there is less evidence on survival beyond infancy. We aimed to systematically review, summarise, and quantify the existing population-based data on long-term survival of individuals born with specific major congenital anomalies and examine the factors associated with survival. METHODS AND FINDINGS: Seven electronic databases (Medline, Embase, Scopus, PsycINFO, CINAHL, ProQuest Natural, and Biological Science Collections), reference lists, and citations of the included articles for studies published 1 January 1995 to 30 April 2020 were searched. Screening for eligibility, data extraction, and quality appraisal were performed in duplicate. We included original population-based studies that reported long-term survival (beyond 1 year of life) of children born with a major congenital anomaly with the follow-up starting from birth that were published in the English language as peer-reviewed papers. Studies on congenital heart defects (CHDs) were excluded because of a recent systematic review of population-based studies of CHD survival. Meta-analysis was performed to pool survival estimates, accounting for trends over time. Of 10,888 identified articles, 55 (n = 367,801 live births) met the inclusion criteria and were summarised narratively, 41 studies (n = 54,676) investigating eight congenital anomaly types (spina bifida [n = 7,422], encephalocele [n = 1,562], oesophageal atresia [n = 6,303], biliary atresia [n = 3,877], diaphragmatic hernia [n = 6,176], gastroschisis [n = 4,845], Down syndrome by presence of CHD [n = 22,317], and trisomy 18 [n = 2,174]) were included in the meta-analysis. These studies covered birth years from 1970 to 2015. Survival for children with spina bifida, oesophageal atresia, biliary atresia, diaphragmatic hernia, gastroschisis, and Down syndrome with an associated CHD has significantly improved over time, with the pooled odds ratios (ORs) of surviving per 10-year increase in birth year being OR = 1.34 (95% confidence interval [95% CI] 1.24-1.46), OR = 1.50 (95% CI 1.38-1.62), OR = 1.62 (95% CI 1.28-2.05), OR = 1.57 (95% CI 1.37-1.81), OR = 1.24 (95% CI 1.02-1.5), and OR = 1.99 (95% CI 1.67-2.37), respectively (p \\textless 0.001 for all, except for gastroschisis [p = 0.029]). There was no observed improvement for children with encephalocele (OR = 0.98, 95% CI 0.95-1.01, p = 0.19) and children with biliary atresia surviving with native liver (OR = 0.96, 95% CI 0.88-1.03, p = 0.26). The presence of additional structural anomalies, low birth weight, and earlier year of birth were the most commonly reported predictors of reduced survival for any congenital anomaly type. The main limitation of the meta-analysis was the small number of studies and the small size of the cohorts, which limited the predictive capabilities of the models resulting in wide confidence intervals. CONCLUSIONS: This systematic review and meta-analysis summarises estimates of long-term survival associated with major congenital anomalies. We report a significant improvement in survival of children with specific congenital anomalies over the last few decades and predict survival estimates up to 20 years of age for those born in 2020. This information is important for the planning and delivery of specialised medical, social, and education services and for counselling affected families. This trial was registered on the PROSPERO database (CRD42017074675).\n

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\n \n\n \n \n \n \n \n Characterization of Esophageal Motility in Children With Operated Esophageal Atresia Using High-resolution Impedance Manometry and Pressure Flow Analysis.\n \n \n \n\n\n \n Courbette, O.; Omari, T.; Aspirot, A.; and Faure, C.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 71(3): 304–309. September 2020.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{courbette_characterization_2020,\n\ttitle = {Characterization of {Esophageal} {Motility} in {Children} {With} {Operated} {Esophageal} {Atresia} {Using} {High}-resolution {Impedance} {Manometry} and {Pressure} {Flow} {Analysis}},\n\tvolume = {71},\n\tissn = {1536-4801},\n\tdoi = {10.1097/MPG.0000000000002806},\n\tabstract = {OBJECTIVES: Esophageal dysmotility is common in patients with esophageal atresia (EA). High-resolution impedance manometry and pressure flow analysis (PFA) allow characterization of biomechanical events that drive bolus flow. The aims were to assess esophageal motility in children with EA, using PFA, and to test whether there is a correlation between PFA parameters and symptoms or endoscopic/histologic findings.\nMETHODS: High-resolution impedance manometry was performed in 16 children with EA (median age 11 years), compared with 13 patient controls (median age 14 years; P = NS vs patients). Wet swallows were analyzed using PFA. Medical charts were reviewed for symptoms and pathology results of the attendant esophagoscopy. Patients with EA were arbitrarily subgrouped according to their motility pattern: group A with presence of distal contraction in ≥50\\% of the swallows and group B with presence of distal contractions in {\\textless}50\\% of the swallows.\nRESULTS: Esophageal peristaltic motor patterns were abnormal in all patients with EA. Bolus transport was impaired as shown by the higher impedance ratio in EA than in controls (0.47 vs 0.22; P {\\textless} 0.001). Impedance ratio was also higher in group B (n = 8) versus group A (n = 8) (P {\\textless} 0.001). Symptoms of dysphagia were not correlated with the PFA measures. Contractile segment impedance, a marker of mucosal integrity, was significantly lower in the EA group.\nCONCLUSIONS: Bolus transport was severely altered in patients with EA but was not predictive of symptoms. The presence of residual distal contractions is associated with a more efficient bolus propulsion.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Courbette, Olivier and Omari, Taher and Aspirot, Ann and Faure, Christophe},\n\tmonth = sep,\n\tyear = {2020},\n\tpmid = {32541198},\n\tkeywords = {Adolescent, Child, Deglutition, Electric Impedance, Esophageal Atresia, Esophageal Motility Disorders, Humans, Manometry},\n\tpages = {304--309},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Developmental changes of upper airway dimensions in children.\n \n \n \n \n\n\n \n Luscan, R.; Leboulanger, N.; Fayoux, P.; Kerner, G.; Belhous, K.; Couloigner, V.; Garabedian, E.; Simon, F.; Denoyelle, F.; and Thierry, B.\n\n\n \n\n\n\n Paediatric Anaesthesia, 30(4): 435–445. April 2020.\n \n\n\n\n
\n\n\n\n \n \n $\"Developmental$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{luscan_developmental_2020,\n\ttitle = {Developmental changes of upper airway dimensions in children},\n\tvolume = {30},\n\tissn = {1460-9592},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/31995659/},\n\tdoi = {10.1111/pan.13832},\n\tabstract = {BACKGROUND: Knowledge about airway dimensions during child growth is of paramount importance for pediatric clinical practice. Decisions about airway management in children are based on relatively limited, imprecise, or incomplete data about airway size.\nAIMS: The aim of this work was to determine the anatomical development and size of airway structures from birth to adolescence using high-resolution computed tomography scans and to study the correlation between airway measurements and biometric data.\nMETHODS: We conducted a retrospective study of all high-resolution computed tomography scans including the respiratory tract, performed in our tertiary pediatric center (for reasons unrelated to airway symptoms) between June 1, 2016, and October 15, 2017, on children aged from 1 day to 14 years old. On each scan, 23 measurements of the larynx, trachea, and mainstem bronchi were performed. Patients were stratified into 16 groups according to their age. We calculated median value for each measurement in each group. Statistical models were calculated to explore correlation between measurements and age or weight.\nRESULTS: A total of 192 scans were included (127 boys/65 girls). The mean age was 7 years. The correlations between airway measurements and age or weight were always significant. The relationship between measurements and age was found to be suitably represented by a cubic polynomial equation suggesting that the airway has a rapid growth phase in the first 3 years, followed by a slow growth phase and a second rapid growth phase during adolescence. The most relevant biometric parameter was age concerning 21 of the measurements.\nCONCLUSION: This comprehensive anatomical database of upper airway dimensions provides important data in the field of pediatric airway anatomy, particularly relating to the cricoid. We demonstrated that laryngeal, tracheal, and bronchial parameters correlate better to age and have three different growth phases.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Paediatric Anaesthesia},\n\tauthor = {Luscan, Romain and Leboulanger, Nicolas and Fayoux, Pierre and Kerner, Gaspard and Belhous, Kahina and Couloigner, Vincent and Garabedian, Erea-Noël and Simon, François and Denoyelle, Françoise and Thierry, Briac},\n\tmonth = apr,\n\tyear = {2020},\n\tpmid = {31995659},\n\tkeywords = {Adolescent, Age Factors, Body Weights and Measures, Bronchi, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Larynx, Male, Retrospective Studies, Tomography, X-Ray Computed, Trachea, age, dimensions, endotracheal tube, pediatric airway, weight},\n\tpages = {435--445},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Frequency of Abnormal Glucose Tolerance Test Suggestive of Dumping Syndrome Following Oesophageal Atresia Repair.\n \n \n \n \n\n\n \n Aumar, M.; Gottrand, F.; Chalouhi, C.; Blanc, S.; Thomassin, N.; Piloquet, H.; Gastineau, S.; Schneider, A.; Krishnan, U.; Duvoisin, G.; Turck, D.; Coopman, S.; and Michaud, L.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 70(6): 820–824. June 2020.\n \n\n\n\n
\n\n\n\n \n \n $\"Frequency$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{aumar_frequency_2020,\n\ttitle = {Frequency of {Abnormal} {Glucose} {Tolerance} {Test} {Suggestive} of {Dumping} {Syndrome} {Following} {Oesophageal} {Atresia} {Repair}},\n\tvolume = {70},\n\tissn = {1536-4801},\n\turl = {https://lilloa.univ-lille.fr/handle/20.500.12210/40722},\n\tdoi = {10.1097/MPG.0000000000002651},\n\tabstract = {OBJECTIVES: Dumping syndrome (DS) is mostly described as a complication of antireflux surgery in oesophageal atresia (OA) but we previously reported 2 cases of DS before any other surgery in infants operated at birth for OA. The objectives of the present study were to assess the prevalence of abnormal oral glucose tolerance test (OGTT) at 3 months of age in infants operated at birth with type C OA, to describe symptoms and clinical features, and to assess risk factors in infants presenting with abnormal OGTT suggestive of DS.\nMETHODS: A prospective case series study including infants with type C OA without fundoplication, born between 2013 and 2016 in 8 centres was conducted. An OGTT was performed between 2.5 and 3.5 months. Abnormal OGTT was defined as early hyperglycaemia ({\\textgreater}1.8 g/L until 30 minutes; {\\textgreater}1.7 g/L between 30 minutes and 2 hours; and {\\textgreater}1.4 g/L between 2 and 3 hours) and/or late hypoglycaemia ({\\textless}0.6 g/L after 2 hours).\nRESULTS: Eleven of the 38 OGTT (29\\%) showed abnormalities. None of the patients' demographics (birth weight, sex, prematurity, associated malformation, use of enteral nutrition) or conditions of the surgery tested was associated with abnormal OGTT. No clinical sign was specific for it.\nCONCLUSIONS: DS should be considered in every infant operated at birth for OA presenting with digestive symptoms. No risk factor was predictive for abnormal OGTT. An OGTT to screen for potential DS around 3 months of age should be considered in infants born with EA.\nCLINICAL TRIAL NAME AND REGISTRATION NUMBER: DUMPING NCT02525705.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Aumar, Madeleine and Gottrand, Frédéric and Chalouhi, Christel and Blanc, Sébastien and Thomassin, Nadège and Piloquet, Hugues and Gastineau, Swellen and Schneider, Anne and Krishnan, Usha and Duvoisin, Gilles and Turck, Dominique and Coopman, Stéphanie and Michaud, Laurent},\n\tmonth = jun,\n\tyear = {2020},\n\tpmid = {32443041},\n\tkeywords = {Dumping Syndrome, Esophageal Atresia, Fundoplication, Glucose Tolerance Test, Humans, Infant, Infant, Newborn, Prospective Studies},\n\tpages = {820--824},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n International Pediatric Otolaryngology Group (IPOG): Consensus recommendations on the prenatal and perinatal management of anticipated airway obstruction.\n \n \n \n \n\n\n \n Puricelli, M. D.; Rahbar, R.; Allen, G. C.; Balakrishnan, K.; Brigger, M. T.; Daniel, S. J.; Fayoux, P.; Goudy, S.; Hewitt, R.; Hsu, W.; Ida, J. B.; Johnson, R.; Leboulanger, N.; Rickert, S. M.; Roy, S.; Russell, J.; Rutter, M.; Sidell, D.; Soma, M.; Thierry, B.; Trozzi, M.; Zalzal, G.; Zdanski, C. J.; and Smith, R. J. H.\n\n\n \n\n\n\n International Journal of Pediatric Otorhinolaryngology, 138: 110281. November 2020.\n \n\n\n\n
\n\n\n\n \n \n $\"International$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{puricelli_international_2020,\n\ttitle = {International {Pediatric} {Otolaryngology} {Group} ({IPOG}): {Consensus} recommendations on the prenatal and perinatal management of anticipated airway obstruction},\n\tvolume = {138},\n\tissn = {1872-8464},\n\tshorttitle = {International {Pediatric} {Otolaryngology} {Group} ({IPOG})},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/32891939/},\n\tdoi = {10.1016/j.ijporl.2020.110281},\n\tabstract = {OBJECTIVE: To make recommendations on the identification, routine evaluation, and management of fetuses at risk for airway compromise at delivery.\nMETHODS: Recommendations are based on expert opinion by members of the International Pediatric Otolaryngology Group (IPOG). A two-iterative Delphi method questionnaire was distributed to all members of the IPOG and responses recorded. The respondents were given the opportunity to comment on the content and format of the survey, which was modified for the second round. "Consensus" was defined by {\\textgreater}80\\% respondent affirmative responses, "agreement" by 51-80\\% affirmative responses, and "no agreement" by 50\\% or less affirmative responses.\nRESULTS: Recommendations are provided regarding etiologies of perinatal airway obstruction, imaging evaluation, adjunct evaluation, multidisciplinary team and decision factors, micrognathia management, congenital high airway obstruction syndrome management, head and neck mass management, attended delivery procedure, and delivery on placental support procedure.\nCONCLUSIONS: Thorough evaluation and thoughtful decision making are required to optimally balance fetal and maternal risks/benefits.},\n\tlanguage = {eng},\n\tjournal = {International Journal of Pediatric Otorhinolaryngology},\n\tauthor = {Puricelli, Michael D. and Rahbar, Reza and Allen, Gregory C. and Balakrishnan, Karthik and Brigger, Matthew T. and Daniel, Sam J. and Fayoux, Pierre and Goudy, Steven and Hewitt, Richard and Hsu, Wei-Chung and Ida, Jonathan B. and Johnson, Romaine and Leboulanger, Nicolas and Rickert, Scott M. and Roy, Soham and Russell, John and Rutter, Michael and Sidell, Douglas and Soma, Marlene and Thierry, Briac and Trozzi, Marilena and Zalzal, George and Zdanski, Carlton J. and Smith, Richard J. H.},\n\tmonth = nov,\n\tyear = {2020},\n\tpmid = {32891939},\n\tkeywords = {Airway Management, Airway Obstruction, Attended delivery, Child, Congenital high airway obstruction syndrome (CHAOS), Consensus, Delivery on placental support, Ex utero intrapartum treatment (EXIT), Female, Fetal head and neck mass, Humans, Micrognathia, Operation on placental support (OOPS), Otolaryngology, Placenta, Pregnancy},\n\tpages = {110281},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n ERNICA Consensus Conference on the Management of Patients with Esophageal Atresia and Tracheoesophageal Fistula: Diagnostics, Preoperative, Operative, and Postoperative Management.\n \n \n \n \n\n\n \n Dingemann, C.; Eaton, S.; Aksnes, G.; Bagolan, P.; Cross, K. M.; De Coppi, P.; Fruithof, J.; Gamba, P.; Husby, S.; Koivusalo, A.; Rasmussen, L.; Sfeir, R.; Slater, G.; Svensson, J. F.; Van der Zee, D. C.; Wessel, L. M.; Widenmann-Grolig, A.; Wijnen, R.; and Ure, B. M.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 30(4): 326–336. August 2020.\n \n\n\n\n
\n\n\n\n \n \n $\"ERNICA$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{dingemann_ernica_2020,\n\ttitle = {{ERNICA} {Consensus} {Conference} on the {Management} of {Patients} with {Esophageal} {Atresia} and {Tracheoesophageal} {Fistula}: {Diagnostics}, {Preoperative}, {Operative}, and {Postoperative} {Management}},\n\tvolume = {30},\n\tissn = {1439-359X},\n\tshorttitle = {{ERNICA} {Consensus} {Conference} on the {Management} of {Patients} with {Esophageal} {Atresia} and {Tracheoesophageal} {Fistula}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/31266084/},\n\tdoi = {10.1055/s-0039-1693116},\n\tabstract = {INTRODUCTION: Many aspects of the management of esophageal atresia (EA) and tracheoesophageal fistula (TEF) are controversial and the evidence for decision making is limited. Members of the European Reference Network for Rare Inherited Congenital Anomalies (ERNICA) conducted a consensus conference on the surgical management of EA/TEF based on expert opinions referring to the latest literature.\nMATERIALS AND METHODS: Nineteen ERNICA representatives from nine European countries participated in the conference. The conference was prepared by item generation, item prioritization by online survey, formulation of a final list containing the domains diagnostics, preoperative, operative, and postoperative management, and literature review. The 2-day conference was held in Berlin in October 2018. Anonymous voting was conducted via an internet-based system. Consensus was defined when 75\\% of the votes scored 6 to 9.\nRESULTS: Fifty-two items were generated with 116 relevant articles of which five studies (4.3\\%) were assigned as level-1evidence. Complete consensus (100\\%) was achieved on 20 items (38\\%), such as TEF closure by transfixing suture, esophageal anastomosis by interrupted sutures, and initiation of feeding 24 hours postoperatively. Consensus ≥75\\% was achieved on 37 items (71\\%), such as routine insertion of transanastomotic tube or maximum duration of thoracoscopy of 3 hours. Thirteen items (25\\%) were controversial (range of scores, 1-9). Eight of these (62\\%) did not reach consensus.\nCONCLUSION: Participants of the conference reached significant consensus on the management of patients with EA/TEF. The consensus may facilitate standardization and development of generally accepted guidelines. The conference methodology may serve as a blueprint for further conferences on the management of congenital malformations in pediatric surgery.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Dingemann, Carmen and Eaton, Simon and Aksnes, Gunnar and Bagolan, Pietro and Cross, Kate M. and De Coppi, Paolo and Fruithof, JoAnne and Gamba, Piergiorgio and Husby, Steffen and Koivusalo, Antti and Rasmussen, Lars and Sfeir, Rony and Slater, Graham and Svensson, Jan F. and Van der Zee, David C. and Wessel, Lucas M. and Widenmann-Grolig, Anke and Wijnen, Rene and Ure, Benno M.},\n\tmonth = aug,\n\tyear = {2020},\n\tpmid = {31266084},\n\tkeywords = {Esophageal Atresia, Esophagoplasty, Humans, Infant, Newborn, Perioperative Care, Postoperative Complications, Thoracoscopy, Thoracotomy, Tracheoesophageal Fistula},\n\tpages = {326--336},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Oesophageal atresia.\n \n \n \n \n\n\n \n van Lennep, M.; Singendonk, M. M. J.; Dall'Oglio, L.; Gottrand, F.; Krishnan, U.; Terheggen-Lagro, S. W. J.; Omari, T. I.; Benninga, M. A.; and van Wijk, M. P.\n\n\n \n\n\n\n Nature Reviews. Disease Primers, 5(1): 26. April 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"Oesophageal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{van_lennep_oesophageal_2019,\n\ttitle = {Oesophageal atresia},\n\tvolume = {5},\n\tissn = {2056-676X},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/31000707/},\n\tdoi = {10.1038/s41572-019-0077-0},\n\tabstract = {Oesophageal atresia (EA) is a congenital abnormality of the oesophagus that is caused by incomplete embryonic compartmentalization of the foregut. EA commonly occurs with a tracheo-oesophageal fistula (TEF). Associated birth defects or anomalies, such as VACTERL association, trisomy 18 or 21 and CHARGE syndrome, occur in the majority of patients born with EA. Although several studies have revealed signalling pathways and genes potentially involved in the development of EA, our understanding of the pathophysiology of EA lags behind the improvements in surgical and clinical care of patients born with this anomaly. EA is treated surgically to restore the oesophageal interruption and, if present, ligate and divide the TEF. Survival is now {\\textasciitilde}90\\% in those born with EA with severe associated anomalies and even higher in those born with EA alone. Despite these achievements, long-term gastrointestinal and respiratory complications and comorbidities in patients born with EA are common and lead to decreased quality of life. Oesophageal motility disorders are probably ubiquitous in patients after undergoing EA repair and often underlie these complications and comorbidities. The implementation of several new diagnostic and screening tools in clinical care, including high-resolution impedance manometry, pH-multichannel intraluminal impedance testing and disease-specific quality of life questionnaires now provide better insight into these problems and may contribute to better long-term outcomes in the future.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Nature Reviews. Disease Primers},\n\tauthor = {van Lennep, Marinde and Singendonk, Maartje M. J. and Dall'Oglio, Luigi and Gottrand, Fréderic and Krishnan, Usha and Terheggen-Lagro, Suzanne W. J. and Omari, Taher I. and Benninga, Marc A. and van Wijk, Michiel P.},\n\tmonth = apr,\n\tyear = {2019},\n\tpmid = {31000707},\n\tkeywords = {Comorbidity, Congenital Abnormalities, Esophageal Atresia, Esophagoscopy, Gastroesophageal Reflux, Humans, Magnetic Resonance Imaging, Mass Screening, Tracheoesophageal Fistula, Ultrasonography},\n\tpages = {26},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Efficacy and Safety of the Local Application of Mitomycin C to Recurrent Esophageal Strictures in Children.\n \n \n \n \n\n\n \n Ley, D.; Bridenne, M.; Gottrand, F.; Lemale, J.; Hauser, B.; Lachaux, A.; Rebouissoux, L.; Viala, J.; Fayoux, P.; and Michaud, L.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 69(5): 528–532. November 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"Efficacy$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{ley_efficacy_2019,\n\ttitle = {Efficacy and {Safety} of the {Local} {Application} of {Mitomycin} {C} to {Recurrent} {Esophageal} {Strictures} in {Children}},\n\tvolume = {69},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/31436711/},\n\tdoi = {10.1097/MPG.0000000000002445},\n\tabstract = {OBJECTIVES: Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children.\nMETHODS: This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4-196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90\\%) patients and multiple in 4 (10\\%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2-26]) over a median period of 7 months (range: 2.6-49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC.\nRESULTS: For 26 (67\\%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P {\\textless} 0.0001). Sixteen (41\\%) patients never required additional dilation during the follow-up after MC application (median: 3.1 years [range: 0.6-8.5]). No complication related to MC was observed. Biopsies at the site of MC application were performed at maximal follow-up in 16 patients and revealed no dysplasia. Three factors were associated with success of MC: single stenosis, short stenosis, and esophageal atresia type III.\nCONCLUSIONS: This study is the largest series reported showing that topical application of MC is an efficient and safe treatment for recurrent esophageal stenosis in children.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Ley, Delphine and Bridenne, Marie and Gottrand, Frédéric and Lemale, Julie and Hauser, Bruno and Lachaux, Alain and Rebouissoux, Laurent and Viala, Jérôme and Fayoux, Pierre and Michaud, Laurent},\n\tmonth = nov,\n\tyear = {2019},\n\tpmid = {31436711},\n\tkeywords = {Administration, Mucosal, Adolescent, Antibiotics, Antineoplastic, Child, Child, Preschool, Esophageal Stenosis, Esophagoscopy, Female, Humans, Infant, Male, Mitomycin, Postoperative Complications, Retrospective Studies},\n\tpages = {528--532},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Epidemiology and Outcome of Major Congenital Malformations in a Large German County.\n \n \n \n\n\n \n Wittekindt, B.; Schloesser, R.; Doberschuetz, N.; Salzmann-Manrique, E.; Grossmann, J.; Misselwitz, B.; and Rolle, U.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 29(3): 282–289. June 2019.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{wittekindt_epidemiology_2019,\n\ttitle = {Epidemiology and {Outcome} of {Major} {Congenital} {Malformations} in a {Large} {German} {County}},\n\tvolume = {29},\n\tissn = {1439-359X},\n\tdoi = {10.1055/s-0038-1642630},\n\tabstract = {INTRODUCTION: Congenital malformations are associated with substantial neonatal morbidity and mortality. Furthermore, only sparse data are available on the modalities of care provided to and the associated clinical outcomes in affected neonates. In this study, we focused on five malformations that require surgery during the neonatal period: duodenal stenosis and atresia (DA), gastroschisis (GA), omphalocele (OM), congenital diaphragmatic herniation (CDH), and esophageal atresia (EA).\nMATERIALS AND METHODS: We reviewed the Hessian neonatal registry (2010-2015) to identify records including the ICD-10 (International Classification of Diseases, Tenth Edition) codes for the aforementioned diagnoses and identified 283 patients who were affected by at least one of these conditions. Multiple regression analyses were performed to further identify risk factors for mortality and extended length of hospital stay.\nRESULTS: The incidence rates per 10,000 live births and inhospital mortality rates were as follows: DA: 1.79 and 3.6\\%; GA: 1.79 and 1.8\\%; OM: 1.60 and 24\\%; CDH: 1.32 and 27.5\\%; and EA: 2.67 and 11.1\\%, respectively. Thirty-three percent of the patients had not been born in a perinatal center in which corrective surgeries were performed. The following risk factors were significantly associated with early mortality: trisomy 13 and 18, congenital heart defects, prematurity, and high-risk malformations (OM and CDH). The predictors of length of stay were as follows: gestational age, number of additional malformations, and treatment in the center with the highest patient volume.\nCONCLUSION: Epidemiology and outcome of major congenital malformations in Hesse, Germany, are comparable to previously published data. In addition, our data revealed a volume-outcome association with regard to the length of hospital stay.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Wittekindt, Boris and Schloesser, Rolf and Doberschuetz, Nora and Salzmann-Manrique, Emilia and Grossmann, Jasmin and Misselwitz, Bjoern and Rolle, Udo},\n\tmonth = jun,\n\tyear = {2019},\n\tpmid = {29715697},\n\tkeywords = {Congenital Abnormalities, Female, Germany, Humans, Infant, Newborn, Length of Stay, Logistic Models, Male, Registries, Risk Factors, Survival Analysis, Treatment Outcome},\n\tpages = {282--289},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Pediatric Feeding Disorder: Consensus Definition and Conceptual Framework.\n \n \n \n\n\n \n Goday, P. S.; Huh, S. Y.; Silverman, A.; Lukens, C. T.; Dodrill, P.; Cohen, S. S.; Delaney, A. L.; Feuling, M. B.; Noel, R. J.; Gisel, E.; Kenzer, A.; Kessler, D. B.; Kraus de Camargo, O.; Browne, J.; and Phalen, J. A.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 68(1): 124–129. January 2019.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{goday_pediatric_2019,\n\ttitle = {Pediatric {Feeding} {Disorder}: {Consensus} {Definition} and {Conceptual} {Framework}},\n\tvolume = {68},\n\tissn = {1536-4801},\n\tshorttitle = {Pediatric {Feeding} {Disorder}},\n\tdoi = {10.1097/MPG.0000000000002188},\n\tabstract = {Pediatric feeding disorders (PFDs) lack a universally accepted definition. Feeding disorders require comprehensive assessment and treatment of 4 closely related, complementary domains (medical, psychosocial, and feeding skill-based systems and associated nutritional complications). Previous diagnostic paradigms have, however, typically defined feeding disorders using the lens of a single professional discipline and fail to characterize associated functional limitations that are critical to plan appropriate interventions and improve quality of life. Using the framework of the World Health Organization International Classification of Functioning, Disability, and Health, a unifying diagnostic term is proposed: "Pediatric Feeding Disorder" (PFD), defined as impaired oral intake that is not age-appropriate, and is associated with medical, nutritional, feeding skill, and/or psychosocial dysfunction. By incorporating associated functional limitations, the proposed diagnostic criteria for PFD should enable practitioners and researchers to better characterize the needs of heterogeneous patient populations, facilitate inclusion of all relevant disciplines in treatment planning, and promote the use of common, precise, terminology necessary to advance clinical practice, research, and health-care policy.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Goday, Praveen S. and Huh, Susanna Y. and Silverman, Alan and Lukens, Colleen T. and Dodrill, Pamela and Cohen, Sherri S. and Delaney, Amy L. and Feuling, Mary B. and Noel, Richard J. and Gisel, Erika and Kenzer, Amy and Kessler, Daniel B. and Kraus de Camargo, Olaf and Browne, Joy and Phalen, James A.},\n\tmonth = jan,\n\tyear = {2019},\n\tpmid = {30358739},\n\tpmcid = {PMC6314510},\n\tkeywords = {Child, Child Nutrition Sciences, Child Nutritional Physiological Phenomena, Consensus, Feeding and Eating Disorders, Gastroenterology, Humans, International Classification of Diseases, International Classification of Functioning, Disability and Health, Pediatrics, World Health Organization},\n\tpages = {124--129},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies.\n \n \n \n\n\n \n Navarro, P.; Arias, Á.; Arias-González, L.; Laserna-Mendieta, E. J.; Ruiz-Ponce, M.; and Lucendo, A. J.\n\n\n \n\n\n\n Alimentary Pharmacology & Therapeutics, 49(9): 1116–1125. May 2019.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{navarro_systematic_2019,\n\ttitle = {Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies},\n\tvolume = {49},\n\tissn = {1365-2036},\n\tshorttitle = {Systematic review with meta-analysis},\n\tdoi = {10.1111/apt.15231},\n\tabstract = {BACKGROUND: The frequency of eosinophilic oesophagitis (EoE) occurrence is escalating. Current diagnostic criteria recently proposed for the disease, determine that previous estimates of incidence and prevalence are outdated.\nAIM: To gauge the current incidence and prevalence of EoE by performing a systematic review of population-based studies.\nMETHODS: Three electronic databases were searched from their inception dates to September 2018. A total of 2386 documents were screened; 29 studies reported on the prevalence and incidence of EoE in the general population.\nRESULTS: The pooled prevalence of EoE was 34.4 cases per 100 000 inhabitants (95\\% CI, 23.1-47.5), and was higher for adults (42.2; 95\\% CI, 31.1-55) than for children (34; 95\\% CI, 22.3-49.2). The pooled EoE incidence rates were 6.6/100 000 person-years (95\\% CI, 3-11.7) in children and 7.7/100 000 (95\\% CI, 1.8-17.8) in adults. No differences were found between North American and European studies using varied sources of data (insurance and administrative databases compared to hospital-bases case series). Subgroup analysis according to risk of bias did not change results significantly. A steady rise in EoE incidence and prevalence rates was observed over time, comparing studies conducted under subsequent definitions for EoE. No significant publication bias was found.\nCONCLUSIONS: In a systematic review and meta-analysis, we found a sharp increase, higher than previous estimates, in the incidence and prevalence of EoE in population based studies. Results from studies carried out in developed countries show broad consistency and provide evidence of increasing pooled prevalence and incidence of EoE rates over time.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Alimentary Pharmacology \\& Therapeutics},\n\tauthor = {Navarro, Pilar and Arias, Ángel and Arias-González, Laura and Laserna-Mendieta, Emilio J. and Ruiz-Ponce, Miriam and Lucendo, Alfredo J.},\n\tmonth = may,\n\tyear = {2019},\n\tpmid = {30887555},\n\tkeywords = {Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Databases, Factual, Developed Countries, Eosinophilic Esophagitis, Female, Humans, Incidence, Male, Middle Aged, Prevalence, Young Adult},\n\tpages = {1116--1125},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n Gastrointestinal diseases among relatives of patients with esophageal atresia with or without tracheoesophageal fistula.\n \n \n \n\n\n \n Zeck, F.; and Reutter, H.\n\n\n \n\n\n\n Translational Pediatrics, 8(5): 378–382. December 2019.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{zeck_gastrointestinal_2019,\n\ttitle = {Gastrointestinal diseases among relatives of patients with esophageal atresia with or without tracheoesophageal fistula},\n\tvolume = {8},\n\tissn = {2224-4344},\n\tdoi = {10.21037/tp.2019.04.01},\n\tabstract = {BACKGROUND: Several studies have identified genetic factors that are associated with the formation of isolated and non-isolated esophageal atresia with or without tracheoesophageal fistula (EA/TEF) in human and mice. Some of these genetic factors like FOXF1/Foxf1 are associated with Barrett syndrome, esophageal carcinoma or tumors of the gastrointestinal tract. Here, we investigated the prevalence of common gastrointestinal diseases among EA/TEF patients and their first- and second-degree relatives (parents and grandparents).\nMETHODS: We send out a questionnaire to 280 EA/TEF families asking for the presence of Barrett syndrome, Achalasia and carcinoma of the esophagus, the stomach, the small and large intestine among first- and second-degree relatives.\nRESULTS: In 32 of 124 families we found at least one affected family member with a possible association of colon carcinoma and the occurrence of EA/TEF within the same family.\nCONCLUSIONS: Further studies are needed to evaluate a possible association.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Translational Pediatrics},\n\tauthor = {Zeck, Florian and Reutter, Heiko},\n\tmonth = dec,\n\tyear = {2019},\n\tpmid = {31993350},\n\tpmcid = {PMC6970114},\n\tkeywords = {Esophageal atresia (EA), gastrointestinal disease, genetic risk factors},\n\tpages = {378--382},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Correlation Between Clinical Signs and High-resolution Manometry Data in Children.\n \n \n \n \n\n\n \n Juzaud, M.; Lamblin, M.; Fabre, A.; Alessandrini, M.; Baumstarck, K.; Bazin, C.; Esteve, C.; Laborde, N.; Osei, L.; Michaud, L.; Gottrand, F.; and Vitton, V.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 68(5): 642–647. May 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"Correlation$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{juzaud_correlation_2019,\n\ttitle = {Correlation {Between} {Clinical} {Signs} and {High}-resolution {Manometry} {Data} in {Children}},\n\tvolume = {68},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/30628985/},\n\tdoi = {10.1097/MPG.0000000000002232},\n\tabstract = {OBJECTIVES: High-resolution manometry (HRM) is the gold standard for diagnosis of esophageal motility disorders. However, clinical signs associated with these disorders are nonspecific, and it is difficult to correlate clinical signs with HRM data. The main objective of our study was to assess the positive predictive value (PPV) and negative predictive value (NPV) of each clinical sign, as well as their sensitivity and specificity in the diagnosis of esophageal motility disorders.\nMETHODS: This is a bicentric retrospective cohort study based on HRM data collected between May 2012 and May 2016. The studied symptoms were weight loss, feeding difficulties, swallowing disorders, dysphagia, food blockages, vomiting, gastroesophageal reflux disease (GERD), belching, and respiratory symptoms. HRM data were analyzed according to the Chicago Classification (3.0).\nRESULTS: In total, 271 HRM data were analyzed, of which 90.4\\% showed abnormal results. HRM was well tolerated in 91\\% of the cases. The most common esophageal motility disorder was ineffective esophageal motility (38\\%). Weight loss was significantly associated (P = 0.003) with an abnormal HRM with a 96\\% PPV.\nCONCLUSIONS: With nonspecific clinical signs suggesting an esophageal motility disorder, weight loss was a predictive sign of abnormal HRM results. HRM was well tolerated in pediatric patients, and ineffective esophageal motility appears to be the most frequent motility disorder in our cohort, as already observed in adult patient studies.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Juzaud, Marine and Lamblin, Marie-Dominique and Fabre, Alexandre and Alessandrini, Marine and Baumstarck, Karine and Bazin, Camille and Esteve, Clothilde and Laborde, Nolwenn and Osei, Lindsay and Michaud, Laurent and Gottrand, Frederic and Vitton, Veronique},\n\tmonth = may,\n\tyear = {2019},\n\tpmid = {30628985},\n\tkeywords = {Adolescent, Child, Child, Preschool, Esophageal Motility Disorders, Female, Humans, Infant, Infant, Newborn, Male, Manometry, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Symptom Assessment, Weight Loss, Young Adult},\n\tpages = {642--647},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Prevalence of Eosinophilic Esophagitis in Adolescents With Esophageal Atresia.\n \n \n \n \n\n\n \n Lardenois, E.; Michaud, L.; Schneider, A.; Onea, M.; Rebeuh, J.; Gottrand-Aumar, M.; Renaud, F.; Gottrand, F.; and Leteurtre, E.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 69(1): 52–56. July 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"Prevalence$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{lardenois_prevalence_2019,\n\ttitle = {Prevalence of {Eosinophilic} {Esophagitis} in {Adolescents} {With} {Esophageal} {Atresia}},\n\tvolume = {69},\n\tissn = {1536-4801},\n\turl = {http://hdl.handle.net/20.500.12210/13784},\n\tdoi = {10.1097/MPG.0000000000002261},\n\tabstract = {BACKGROUND AND OBJECTIVE: Eosinophilic esophagitis (EoE) is an increasingly recognized childhood disease. Esophageal atresia (EA) is the most frequent congenital malformation of the esophagus. Recently, cases of EoE occurring in patients with EA have been reported, although the exact prevalence of EoE in EA remains unknown. The aim is to investigate the prevalence of EoE among EA in adolescents and to describe these patients' characteristics.\nMETHODS: Systematic upper gastrointestinal endoscopies with multistage esophageal biopsies were prospectively performed in 63 adolescents with EA. A standardized form was used to collect clinical and endoscopic data. Diagnosis of EoE was made as ≥15 intraepithelial eosinophils/high power field, whatever the response on proton pump inhibitors therapy.\nRESULTS: Six patients (9.5\\%) presented an EoE (17-100 eosinophils/high power field). An atopic condition was reported more frequently in the eosinophil ≥15 group than in patients with no EoE (66\\% vs 16\\%; P = 0.014). Except for chest pain, symptoms and endoscopic features were similar in patients with EoE and patients with no EoE.\nCONCLUSION: In our series of 63 patients born with EA, mainly distal tracheoesophageal fistula, the prevalence of EoE is increased, and therefore should be considered in adolescents with EA.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Lardenois, Emilie and Michaud, Laurent and Schneider, Anne and Onea, Mihaela and Rebeuh, Julie and Gottrand-Aumar, Madeleine and Renaud, Florence and Gottrand, Frederic and Leteurtre, Emmanuelle},\n\tmonth = jul,\n\tyear = {2019},\n\tpmid = {30614952},\n\tkeywords = {Adolescent, Case-Control Studies, Chest Pain, Endoscopy, Gastrointestinal, Eosinophilic Esophagitis, Eosinophils, Erythema, Esophageal Atresia, Female, Humans, Hypersensitivity, Leukocyte Count, Male, Prevalence, Prospective Studies, Proton Pump Inhibitors, Tracheoesophageal Fistula, Ulcer},\n\tpages = {52--56},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n The Use of Jejunal Tube Feeding in Children: A Position Paper by the Gastroenterology and Nutrition Committees of the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition 2019.\n \n \n \n \n\n\n \n Broekaert, I. J.; Falconer, J.; Bronsky, J.; Gottrand, F.; Dall'Oglio, L.; Goto, E.; Hojsak, I.; Hulst, J.; Kochavi, B.; Papadopoulou, A.; Ribes-Koninckx, C.; Schaeppi, M.; Werlin, S.; Wilschanski, M.; and Thapar, N.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 69(2): 239–258. August 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{broekaert_use_2019,\n\ttitle = {The {Use} of {Jejunal} {Tube} {Feeding} in {Children}: {A} {Position} {Paper} by the {Gastroenterology} and {Nutrition} {Committees} of the {European} {Society} for {Paediatric} {Gastroenterology}, {Hepatology}, and {Nutrition} 2019},\n\tvolume = {69},\n\tissn = {1536-4801},\n\tshorttitle = {The {Use} of {Jejunal} {Tube} {Feeding} in {Children}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/31169666/},\n\tdoi = {10.1097/MPG.0000000000002379},\n\tabstract = {OBJECTIVES: Jejunal tube feeding (JTF) is increasingly becoming the standard of care for children in whom gastric tube feeding is insufficient to achieve caloric needs. Given a lack of a systematic approach to the care of JTF in paediatric patients, the aim of this position paper is to provide expert guidance regarding the indications for its use and practical considerations to optimize its utility and safety.\nMETHODS: A group of members of the Gastroenterology and Nutrition Committees of the European Society of Paediatric Gastroenterology Hepatology and Nutrition and of invited experts in the field was formed in September 2016 to produce this clinical guide. Seventeen clinical questions treating indications and contraindications, investigations before placement, techniques of placement, suitable feeds and feeding regimen, weaning from JTF, complications, long-term care, and ethical considerations were addressed.A systematic literature search was performed from 1982 to November 2018 using PubMed, the MEDLINE, and Cochrane Database of Systematic Reviews. Grading of Recommendations, Assessment, Development, and Evaluation was applied to evaluate the outcomes.During a consensus meeting, all recommendations were discussed and finalized. In the absence of evidence from randomized controlled trials, recommendations reflect the expert opinion of the authors.\nRESULTS: A total of 33 recommendations were voted on using the nominal voting technique.\nCONCLUSIONS: JTF is a safe and effective means of enteral feeding when gastric feeding is insufficient to meet caloric needs or is not possible. The decision to place a jejunal tube has to be made by close cooperation of a multidisciplinary team providing active follow-up and care.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Broekaert, Ilse J. and Falconer, Jackie and Bronsky, Jiri and Gottrand, Frederic and Dall'Oglio, Luigi and Goto, Eunice and Hojsak, Iva and Hulst, Jessie and Kochavi, Brigitte and Papadopoulou, Alexandra and Ribes-Koninckx, Carmen and Schaeppi, Michela and Werlin, Steven and Wilschanski, Michael and Thapar, Nikhil},\n\tmonth = aug,\n\tyear = {2019},\n\tpmid = {31169666},\n\tkeywords = {Child, Child Nutritional Physiological Phenomena, Enteral Nutrition, Europe, Gastrointestinal Diseases, Humans, Jejunostomy, Jejunum, Nutritional Requirements, Practice Guidelines as Topic, Societies, Medical},\n\tpages = {239--258},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Protocole national de diagnostic et de soins (PNDS) : atrésie de l’œsophage.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Perfectionnement en Pédiatrie, 2(2): 98–115. June 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"Protocole$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@article{noauthor_protocole_2019,\n\ttitle = {Protocole national de diagnostic et de soins ({PNDS}) : atrésie de l’œsophage},\n\tvolume = {2},\n\tissn = {2588932X},\n\tshorttitle = {Protocole national de diagnostic et de soins ({PNDS})},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S2588932X19300452},\n\tdoi = {10.1016/j.perped.2019.04.002},\n\tlanguage = {fr},\n\tnumber = {2},\n\turldate = {2022-03-11},\n\tjournal = {Perfectionnement en Pédiatrie},\n\tmonth = jun,\n\tyear = {2019},\n\tpages = {98--115},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Predictors of the Performance of Early Antireflux Surgery in Esophageal Atresia.\n \n \n \n \n\n\n \n François, B.; Michaud, L.; Sfeir, R.; Bonnard, A.; Rousseau, V.; Blanc, S.; Gelas, T.; Boubnova, J.; Jacquier, C.; Irtan, S.; Breton, A.; Fouquet, V.; Guinot, A.; Lamireau, T.; Habounimana, E.; Schneider, A.; Elbaz, F.; Ranke, A.; Poli-Merol, M.; Kalfa, N.; Dupont-Lucas, C.; Petit, T.; Michel, J.; Buisson, P.; Lirussi-Borgnon, J.; Sapin, E.; Lardy, H.; Levard, G.; Parmentier, B.; Cremillieux, C.; Lopez, M.; Podevin, G.; Schmitt, F.; Borderon, C.; Jaby, O.; Pelatan, C.; De Vries, P.; Pouzac-Arnould, M.; Grosos, C.; Breaud, J.; Laplace, C.; Tolg, C.; Sika, A.; Auber, F.; Labreuche, J.; Duhamel, A.; and Gottrand, F.\n\n\n \n\n\n\n The Journal of Pediatrics, 211: 120–125.e1. August 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"Predictors$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{francois_predictors_2019,\n\ttitle = {Predictors of the {Performance} of {Early} {Antireflux} {Surgery} in {Esophageal} {Atresia}},\n\tvolume = {211},\n\tissn = {1097-6833},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/31072651/},\n\tdoi = {10.1016/j.jpeds.2019.03.045},\n\tabstract = {OBJECTIVE: To identify predictors of and factors associated with the performance of antireflux surgery during the first year of life in children born with esophageal atresia.\nSTUDY DESIGN: All patients were included in a French registry for esophageal atresia. All 38 multidisciplinary French centers completed questionnaires about perinatal characteristics and one-year outcome for children born with esophageal atresia.\nRESULTS: Of 835 infants with esophageal atresia born in France from 2010 to 2014, 682 patients, excluding those with long-gap esophageal atresia, were included. Three patients had type I, 669 had type III, and 10 had type IV esophageal atresia. Fifty-three children (7.8\\%) received fundoplication during the first year of life. The median age at the time of the end-to-end esophageal anastomosis was 1.1 day (range 0-15). Multivariate analysis identified three perioperative factors that predicted the need for early antireflux surgery: anastomotic tension (P = .004), associated malformations (P = .019), and low birth weight (P = .018). Six other factors, measured during the first year of life, were associated with the need for antireflux surgery: gastroesophageal reflux (P {\\textless} .001), anastomotic stricture (P {\\textless} .001), gastrostomy (P {\\textless} .001), acute life-threatening event (P = .002), respiratory complications (P = .045), and poor nutritional status (P {\\textless} .001).\nCONCLUSIONS: Gastroesophageal reflux disease, low birth weight, poor nutrition, and surgical anastomosis difficulties predicted the performance of antireflux surgery in the first year of life in infants with esophageal atresia.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {François, Berengere and Michaud, Laurent and Sfeir, Rony and Bonnard, Arnaud and Rousseau, Veronique and Blanc, Sebastien and Gelas, Thomas and Boubnova, Julia and Jacquier, Catherine and Irtan, Sabine and Breton, Anne and Fouquet, Virginie and Guinot, Audrey and Lamireau, Thierry and Habounimana, Edouard and Schneider, Anne and Elbaz, Frederic and Ranke, Aline and Poli-Merol, Marie-Laurence and Kalfa, Nicolas and Dupont-Lucas, Claire and Petit, Thierry and Michel, Jean-Luc and Buisson, Philippe and Lirussi-Borgnon, Josephine and Sapin, Emmanuel and Lardy, Hubert and Levard, Guillaume and Parmentier, Benoit and Cremillieux, Clara and Lopez, Manuel and Podevin, Guillaume and Schmitt, Françoise and Borderon, Corinne and Jaby, Olivier and Pelatan, Cecile and De Vries, Philine and Pouzac-Arnould, Myriam and Grosos, Celine and Breaud, Jean and Laplace, Christophe and Tolg, Cecilia and Sika, Anicet and Auber, Frederic and Labreuche, Julien and Duhamel, Alain and Gottrand, Frederic},\n\tmonth = aug,\n\tyear = {2019},\n\tpmid = {31072651},\n\tkeywords = {Anastomosis, Surgical, Constriction, Pathologic, Esophageal Atresia, Female, France, Fundoplication, Gastroesophageal Reflux, Gastrostomy, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Male, Multivariate Analysis, Nutritional Status, Registries, antireflux surgery, esophageal atresia, fundoplication, gastroesophageal reflux disease, infant},\n\tpages = {120--125.e1},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER).\n \n \n \n \n\n\n \n Hoofien, A.; Dias, J. A.; Malamisura, M.; Rea, F.; Chong, S.; Oudshoorn, J.; Nijenhuis-Hendriks, D.; Otte, S.; Papadopoulou, A.; Romano, C.; Gottrand, F.; Miravet, V. V.; Orel, R.; Oliva, S.; Junquera, C. G.; Załęski, A.; Urbonas, V.; Garcia-Puig, R.; Gomez, M. J. M.; Dominguez-Ortega, G.; Auth, M. K.; Kori, M.; Ben Tov, A.; Kalach, N.; Velde, S. V.; Furman, M.; Miele, E.; Marderfeld, L.; Roma, E.; and Zevit, N.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 68(4): 552–558. April 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"Pediatric$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{hoofien_pediatric_2019,\n\ttitle = {Pediatric {Eosinophilic} {Esophagitis}: {Results} of the {European} {Retrospective} {Pediatric} {Eosinophilic} {Esophagitis} {Registry} ({RetroPEER})},\n\tvolume = {68},\n\tissn = {1536-4801},\n\tshorttitle = {Pediatric {Eosinophilic} {Esophagitis}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/30540712/},\n\tdoi = {10.1097/MPG.0000000000002215},\n\tabstract = {OBJECTIVES: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists diagnosing and treating EoE and to identify the triggering allergens in European children.\nMETHODS: Retrospective anonymized data were collected from 26 European pediatric gastroenterology centers in 13 countries. Inclusion criteria were: Patients diagnosis with EoE, completed investigations prescribed by the treating physician, and were on stable medical or dietary interventions.\nRESULTS: In total, 410 patients diagnosed between December 1999 and June 2016 were analyzed, 76.3\\% boys. The time from symptoms to diagnosis was 12 ± 33.5 months and age at diagnosis was 8.9 ± 4.75 years. The most frequent indications for endoscopy were: dysphagia (38\\%), gastroesophageal reflux (31.2\\%), bolus impaction (24.4\\%), and failure to thrive (10.5\\%). Approximately 70.3\\% had failed proton pump inhibitor treatment. The foods found to be causative of EoE by elimination and rechallenge were milk (42\\%), egg (21.5\\%), wheat/gluten (10.9\\%), and peanut (9.9\\%). Elimination diets were used exclusively in 154 of 410 (37.5\\%), topical steroids without elimination diets in 52 of 410 (12.6\\%), both diet and steroids in 183 of 410 (44.6\\%), systemic steroids in 22 of 410 (5.3\\%), and esophageal dilation in 7 of 410 (1.7\\%). Patient refusal, shortage of endoscopy time, and reluctance to perform multiple endoscopies per patient were noted as factors justifying deviation from guidelines.\nCONCLUSIONS: In this "real world" pediatric European cohort, milk and egg were the most common allergens triggering EoE. Although high-dose proton pump inhibitor trials have increased, attempted PPI treatment is not universal.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Hoofien, Assaf and Dias, Jorge A. and Malamisura, Monica and Rea, Francesca and Chong, Sonny and Oudshoorn, Johanna and Nijenhuis-Hendriks, Danielle and Otte, Sebastian and Papadopoulou, Alexandra and Romano, Claudio and Gottrand, Frederic and Miravet, Victor V. and Orel, Rok and Oliva, Salvatore and Junquera, Carolina G. and Załęski, Andrzej and Urbonas, Vaidotas and Garcia-Puig, Roger and Gomez, Maria J. M. and Dominguez-Ortega, Gloria and Auth, Marcus K.-H. and Kori, Michal and Ben Tov, Amir and Kalach, Nicolas and Velde, Saskia V. and Furman, Mark and Miele, Erasmo and Marderfeld, Luba and Roma, Eleftheria and Zevit, Noam},\n\tmonth = apr,\n\tyear = {2019},\n\tpmid = {30540712},\n\tkeywords = {Adolescent, Child, Child, Preschool, Eosinophilic Esophagitis, Europe, Female, Humans, Male, Registries, Retrospective Studies},\n\tpages = {552--558},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n DOZ047.22: FEED-EASY: feeding disorders in children with esophageal atresia study.\n \n \n \n \n\n\n \n Pham, A; Dugelay, E; Bonnard, A; Gelas, T; Rousseau, V; Thomassin, N; Cabon-Boudard, I; Michaud, L; Guinot, A; Rebeuh, J; Mandat, A L E; Djeddi, D; Fouquet, V; Bourchany, A; Irtan, S; Comte, A; Bridoux-Henno, L; Dupont, C; Dimitrov, G; Turquet, A; Borderon, C; Pelatan, C; Legault, E C; Jung, C; Willot, S; Gottrand, F; and Bellaiche, M\n\n\n \n\n\n\n Diseases of the Esophagus, 32(Supplement_1): doz047.22. June 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"DOZ047.22:$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@article{pham_doz04722_2019,\n\ttitle = {{DOZ047}.22: {FEED}-{EASY}: feeding disorders in children with esophageal atresia study},\n\tvolume = {32},\n\tissn = {1120-8694},\n\tshorttitle = {{DOZ047}.22},\n\turl = {https://doi.org/10.1093/dote/doz047.22},\n\tdoi = {10.1093/dote/doz047.22},\n\tabstract = {With advances in surgical and neonatal care, survival of patients with esophageal atresia (EA) has improved over time. While a number of conditions associated with EA may have an impact on feeding development (delayed primary anastomosis, anastomotic leaks, recurrent tracheoesophageal fistula, anastomotic stricture, gastroesophageal reflux, esophageal dysmotility, etc.) and although children with EA experience a number of oral aversive events in their first year of life, feeding disorders (FD) are poorly described and frequently unrecognized. The primary aim of this study was to describe FD in children born with EA, with a standardized scale. The secondary aim was to describe conditions associated with FD.FEED-EASY is a multicentric French study. Parents of children born with EA between 2013 and 2016 in one of the 22 participating centers were asked to participate and received the French version of the standardized and reproductive ‘Montreal Children's Hospital Feeding Scale (MCH-FS)’.One hundred and forty-five children were included; 61 (42\\%) had FD according to the MCH-FS. These children were characterized by disinterest in food, oral hypersensitivity, difficulty in touching some textures and food avoidance, with an influence in quality of life. Nineteen (13\\%) were tube-fed between 1 and 4 years of age. Birth weight and chronic respiratory difficulties were associated with FD in children with EA. Anastomotic stricture (present in 31\\% of the included children) was not associated with FD.FD is frequent and unrecognized in children with EA, and can influence growth and quality of life. MCH-FS allows pediatricians to identify FD in children with EA within a couple of minutes.},\n\tnumber = {Supplement\\_1},\n\turldate = {2024-08-21},\n\tjournal = {Diseases of the Esophagus},\n\tauthor = {Pham, A and Dugelay, E and Bonnard, A and Gelas, T and Rousseau, V and Thomassin, N and Cabon-Boudard, I and Michaud, L and Guinot, A and Rebeuh, J and Mandat, A L E and Djeddi, D and Fouquet, V and Bourchany, A and Irtan, S and Comte, A and Bridoux-Henno, L and Dupont, C and Dimitrov, G and Turquet, A and Borderon, C and Pelatan, C and Legault, E C and Jung, C and Willot, S and Gottrand, F and Bellaiche, M},\n\tmonth = jun,\n\tyear = {2019},\n\tpages = {doz047.22},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n DOZ047.09: Experience of speech therapy follow-up for children with esophageal atresia.\n \n \n \n \n\n\n \n Lecoufle, A; Michaud, L; Hanafi, M; Lejeune, S; Gottrand, L; Sfeir, R; and Gottrand, F\n\n\n \n\n\n\n Diseases of the Esophagus, 32(Supplement_1): doz047.09. June 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"DOZ047.09:$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@article{lecoufle_doz04709_2019,\n\ttitle = {{DOZ047}.09: {Experience} of speech therapy follow-up for children with esophageal atresia},\n\tvolume = {32},\n\tissn = {1120-8694},\n\tshorttitle = {{DOZ047}.09},\n\turl = {https://doi.org/10.1093/dote/doz047.09},\n\tdoi = {10.1093/dote/doz047.09},\n\tnumber = {Supplement\\_1},\n\turldate = {2024-08-21},\n\tjournal = {Diseases of the Esophagus},\n\tauthor = {Lecoufle, A and Michaud, L and Hanafi, M and Lejeune, S and Gottrand, L and Sfeir, R and Gottrand, F},\n\tmonth = jun,\n\tyear = {2019},\n\tpages = {doz047.09},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n DOZ047.01: Risk factors for anastomotic strictures in the first year after esophageal atresia repair: data from a prospective multicentric cohort.\n \n \n \n \n\n\n \n Aumar, M; Rousseau, V; Bonnard, A; Sfeir, R; Gelas, T; Boubnova, J; Jacquier, C; Irtan, S; Breton, A; Guinot, A; Lamireau, T; Fouquet, V; Habonimana, E; Schneider, A; Elbaz, F; Ranke, A; Polimerol, M L; Allal, H; Michel, J L; Buisson, P; Petit, T; Sapin, E; Lopez, M; Levard, G; Schmitt, F; Lardy, H; Borderon, C; Jaby, O; Breaud, J; Pelatan, C; Auber, F; Tolg, C; De Vries, P; Pouzac, M; Grosos, C; Geiss, S; Laplace, C; Pierache, A; Gottrand, F; and Michaud, L\n\n\n \n\n\n\n Diseases of the Esophagus, 32(Supplement_1): doz047.01. June 2019.\n \n\n\n\n
\n\n\n\n \n \n $\"DOZ047.01:$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@article{aumar_doz04701_2019,\n\ttitle = {{DOZ047}.01: {Risk} factors for anastomotic strictures in the first year after esophageal atresia repair: data from a prospective multicentric cohort},\n\tvolume = {32},\n\tissn = {1120-8694},\n\tshorttitle = {{DOZ047}.01},\n\turl = {https://doi.org/10.1093/dote/doz047.01},\n\tdoi = {10.1093/dote/doz047.01},\n\tabstract = {Anastomotic stricture (AS) is a frequent complication of the surgery for œsophageal atresia (OA) during the first year of life. The primary objective of this study was to evaluate the prevalence of AS before 1 year old in infants with type A and C OA who were operated on. Secondary objectives were to determine risk factors for AS in OA, for recurrent and refractory AS, and to establish if AS is associated with antireflux surgery.A prospective national multicentric study was conducted including all infants born with OA between 2008 and 2015. Patients deceased before one year old, OA types B and E, and patients for whom data about AS were missing were excluded from the study. Data were collected at birth and at 12 months of age. Anastomosis under tension was defined by the surgeon and a delayed anastomosis was defined by an anastomosis after 15 days of life. Recurrent stricture was defined by the need of ≥3 dilations and refractory stricture was defined by the need of ≥5 dilations. Univariate and multivariate statistical analyses were conducted.Of the 1258 eligible patients (84\\%), 1054 were included in the study from 38 centers. The prevalence of AS in the first year of life was 23.3\\% [20.7–28.9]. Anastomosis under tension (AUT) and delayed anastomosis (DA) were found to be independent risk factors for AS (respectively 2.5 [1.73–3.45] and 3.7 [1.95–7.2] (OR [CL 95\\%])) in the total population. Neither sex, birth weight, prematurity, intrauterine growth retardation, associated malformations, type A OA, nor the type of surgical approach was a risk factor for AS. In type C OA, DA was the only risk factor for AS (OR: 3.1 [1.65–5.86]). The group with AS had 2.5-fold more fundoplication compared to the patients without AS (P = 0.0005) in the total population and in type C OA. AUT and DA were found to be independent risk factors for recurrent stricture (OR: 2.4 [1.47–3.9] and 4.7 [2.2–10.4], respectively) and DA was the only risk factor for refractory stricture (OR: 6.23 [2.4–16.2]).Surgical factors at the time of first repair of OA are the only risk factors for AS.},\n\tnumber = {Supplement\\_1},\n\turldate = {2024-08-21},\n\tjournal = {Diseases of the Esophagus},\n\tauthor = {Aumar, M and Rousseau, V and Bonnard, A and Sfeir, R and Gelas, T and Boubnova, J and Jacquier, C and Irtan, S and Breton, A and Guinot, A and Lamireau, T and Fouquet, V and Habonimana, E and Schneider, A and Elbaz, F and Ranke, A and Polimerol, M L and Allal, H and Michel, J L and Buisson, P and Petit, T and Sapin, E and Lopez, M and Levard, G and Schmitt, F and Lardy, H and Borderon, C and Jaby, O and Breaud, J and Pelatan, C and Auber, F and Tolg, C and De Vries, P and Pouzac, M and Grosos, C and Geiss, S and Laplace, C and Pierache, A and Gottrand, F and Michaud, L},\n\tmonth = jun,\n\tyear = {2019},\n\tpages = {doz047.01},\n}\n\n\n\n

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\n Anastomotic stricture (AS) is a frequent complication of the surgery for œsophageal atresia (OA) during the first year of life. The primary objective of this study was to evaluate the prevalence of AS before 1 year old in infants with type A and C OA who were operated on. Secondary objectives were to determine risk factors for AS in OA, for recurrent and refractory AS, and to establish if AS is associated with antireflux surgery.A prospective national multicentric study was conducted including all infants born with OA between 2008 and 2015. Patients deceased before one year old, OA types B and E, and patients for whom data about AS were missing were excluded from the study. Data were collected at birth and at 12 months of age. Anastomosis under tension was defined by the surgeon and a delayed anastomosis was defined by an anastomosis after 15 days of life. Recurrent stricture was defined by the need of ≥3 dilations and refractory stricture was defined by the need of ≥5 dilations. Univariate and multivariate statistical analyses were conducted.Of the 1258 eligible patients (84%), 1054 were included in the study from 38 centers. The prevalence of AS in the first year of life was 23.3% [20.7–28.9]. Anastomosis under tension (AUT) and delayed anastomosis (DA) were found to be independent risk factors for AS (respectively 2.5 [1.73–3.45] and 3.7 [1.95–7.2] (OR [CL 95%])) in the total population. Neither sex, birth weight, prematurity, intrauterine growth retardation, associated malformations, type A OA, nor the type of surgical approach was a risk factor for AS. In type C OA, DA was the only risk factor for AS (OR: 3.1 [1.65–5.86]). The group with AS had 2.5-fold more fundoplication compared to the patients without AS (P = 0.0005) in the total population and in type C OA. AUT and DA were found to be independent risk factors for recurrent stricture (OR: 2.4 [1.47–3.9] and 4.7 [2.2–10.4], respectively) and DA was the only risk factor for refractory stricture (OR: 6.23 [2.4–16.2]).Surgical factors at the time of first repair of OA are the only risk factors for AS.\n

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\n \n\n \n \n \n \n \n \n Thoracic skeletal anomalies following surgical treatment of esophageal atresia. Lessons from a national cohort.\n \n \n \n \n\n\n \n Bastard, F.; Bonnard, A.; Rousseau, V.; Gelas, T.; Michaud, L.; Irtan, S.; Piolat, C.; Ranke-Chrétien, A.; Becmeur, F.; Dariel, A.; Lamireau, T.; Petit, T.; Fouquet, V.; Le Mandat, A.; Lefebvre, F.; Allal, H.; Borgnon, J.; Boubnova, J.; Habonimana, E.; Panait, N.; Buisson, P.; Margaryan, M.; Michel, J.; Gaudin, J.; Lardy, H.; Auber, F.; Borderon, C.; De Vries, P.; Jaby, O.; Fourcade, L.; Lecompte, J. F.; Tolg, C.; Delorme, B.; Schmitt, F.; and Podevin, G.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 53(4): 605–609. April 2018.\n \n\n\n\n
\n\n\n\n \n \n $\"Thoracic$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{bastard_thoracic_2018,\n\ttitle = {Thoracic skeletal anomalies following surgical treatment of esophageal atresia. {Lessons} from a national cohort},\n\tvolume = {53},\n\tissn = {1531-5037},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/28778692/},\n\tdoi = {10.1016/j.jpedsurg.2017.07.013},\n\tabstract = {INTRODUCTION: Thoracotomy as surgical approach for esophageal atresia treatment entails the risk of deformation of the rib cage and consequently secondary thoracogenic scoliosis. The aim of our study was to assess these thoracic wall anomalies on a large national cohort and search for factors influencing this morbidity.\nMATERIALS AND METHODS: Pediatric surgery departments from our national network were asked to send recent thoracic X-ray and operative reports for patients born between 2008 and 2010 with esophageal atresia. The X-rays were read in a double-blind manner to detect costal and vertebral anomalies.\nRESULTS: Among 322 inclusions from 32 centers, 110 (34.2\\%) X-rays were normal and 25 (7.7\\%) displayed thoracic malformations, including 14 hemivertebrae. We found 187 (58.1\\%) sequelae of surgery, including 85 costal hypoplasia, 47 other types of costal anomalies, 46 intercostal space anomalies, 21 costal fusions and 12 scoliosis, with some patients suffering from several lesions. The rate of patients with these sequelae was not influenced by age at intervention, weight at birth, type of atresia, number of thoracotomy or size of the center. The rate of sequelae was higher following a classical thoracotomy (59.1\\%), whatever the way that thoracotomy was performed, compared to nonconverted thoracoscopy (22.2\\%; p=0.04).\nCONCLUSION: About 60 \\% of the patients suffered from a thoracic wall morbidity caused by the thoracotomy performed as part of surgical treatment of esophageal atresia. Minimally invasive techniques reduced thoracic wall morbidity. Further studies should be carried out to assess the potential benefit of minimally invasive approaches to patient pulmonary functions and on the occurrence of thoracogenic scoliosis in adulthood.\nLEVELS OF EVIDENCE: Level III retrospective comparative treatment study.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Bastard, François and Bonnard, Arnaud and Rousseau, Véronique and Gelas, Thomas and Michaud, Laurent and Irtan, Sabine and Piolat, Christian and Ranke-Chrétien, Aline and Becmeur, François and Dariel, Anne and Lamireau, Thierry and Petit, Thierry and Fouquet, Virginie and Le Mandat, Aurélie and Lefebvre, Francis and Allal, Hossein and Borgnon, Josephine and Boubnova, Julia and Habonimana, Edouard and Panait, Nicoleta and Buisson, Philippe and Margaryan, Marc and Michel, Jean-Luc and Gaudin, Jean and Lardy, Hubert and Auber, Frédéric and Borderon, Corinne and De Vries, Philine and Jaby, Olivier and Fourcade, Laurent and Lecompte, Jean François and Tolg, Cécilia and Delorme, Benoit and Schmitt, Françoise and Podevin, Guillaume},\n\tmonth = apr,\n\tyear = {2018},\n\tpmid = {28778692},\n\tkeywords = {Child, Digestive System Surgical Procedures, Esophageal Atresia, Esophageal atresia, Female, Humans, Male, Musculoskeletal Abnormalities, Radiography, Radiography, Thoracic, Retrospective Studies, Thoracic Diseases, Thoracic wall, Thoracoscopy, Thoracotomy, Treatment Outcome},\n\tpages = {605--609},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Laryngotracheal anomalies associated with esophageal atresia: importance of early diagnosis.\n \n \n \n \n\n\n \n Fayoux, P.; Morisse, M.; Sfeir, R.; Michaud, L.; and Daniel, S.\n\n\n \n\n\n\n European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 275(2): 477–481. February 2018.\n \n\n\n\n
\n\n\n\n \n \n $\"Laryngotracheal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{fayoux_laryngotracheal_2018,\n\ttitle = {Laryngotracheal anomalies associated with esophageal atresia: importance of early diagnosis},\n\tvolume = {275},\n\tissn = {1434-4726},\n\tshorttitle = {Laryngotracheal anomalies associated with esophageal atresia},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/29299746/},\n\tdoi = {10.1007/s00405-017-4856-5},\n\tabstract = {OBJECTIVE: Esophageal atresia (EA) is the most common congenital esophageal malformation. Airway pathology, in particular, tracheomalacia and laryngotracheal anomalies is a major cause of morbidity and mortalilty in patients with EA. The aim of this study was to report the incidence and type of laryngotracheal anomalies seen in a large series of patients with EA, and to evaluate their impact on the management of children with EA.\nSTUDY DESIGN: Retrospective study.\nMATERIALS AND METHODS: Retrospective cohort including all patients referred to the EA National Reference Center from January 2002 to December 2014. Airway assessment was based on endoscopy performed before, during and/or after esophageal surgery.\nRESULTS: One-hundred and fifty-eight patients were included in the study. Endoscopy revealed tracheomalacia in 141 cases (89.2\\%) and other laryngotracheal anomalies in 43 patients (27.2\\%). Ninety-six patients (60.7\\%) presented with persistent respiratory symptoms, including acute life-threatening events in 21 cases, leading to death in 6 cases. A correlation was observed between degree of tracheal collapse and presence of acute life-threatening events. Laryngotracheal surgery was required in 35 cases (22\\%).\nCONCLUSION: Laryngotracheal anomalies are frequently associated with EA and represent an important etiology of morbidity and mortality that can be prevented by early and systematic diagnosis and aggressive management. An early systematic endoscopic evaluation is recommended to coordinate the airway management with the EA surgery.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery},\n\tauthor = {Fayoux, Pierre and Morisse, Martin and Sfeir, Rony and Michaud, Laurent and Daniel, Sam},\n\tmonth = feb,\n\tyear = {2018},\n\tpmid = {29299746},\n\tkeywords = {Abnormalities, Multiple, Early Diagnosis, Endoscopy, Esophageal Atresia, Esophageal atresia, Esophagoscopy, Female, Humans, Infant, Infant, Newborn, Laryngeal cleft, Laryngotracheal anomalies, Larynx, Male, Retrospective Studies, Surgery, Trachea, Tracheomalacia},\n\tpages = {477--481},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Can Patients With Neonatal Digestive Diseases Be Protected From Unnecessary Radiation?.\n \n \n \n \n\n\n \n Gottrand, F.; and Avni, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 66(2): 187. February 2018.\n \n\n\n\n
\n\n\n\n \n \n $\"Can$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gottrand_can_2018,\n\ttitle = {Can {Patients} {With} {Neonatal} {Digestive} {Diseases} {Be} {Protected} {From} {Unnecessary} {Radiation}?},\n\tvolume = {66},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/28937542/},\n\tdoi = {10.1097/MPG.0000000000001751},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Gottrand, Frédéric and Avni, Freddy},\n\tmonth = feb,\n\tyear = {2018},\n\tpmid = {28937542},\n\tkeywords = {Digestion, Digestive System Diseases, Esophageal Atresia, Humans, Infant, Newborn, Neoplasms, Radiation Exposure},\n\tpages = {187},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Congenital Esophageal Atresia and Microtia in a Newborn Secondary to Mycophenolate Mofetil Exposure During Pregnancy: A Case Report and Review of the Literature.\n \n \n \n\n\n \n Alsebayel, M. M.; Abaalkhail, F. A.; Alsebayel, F. M.; Alissa, D. A.; Al-Jedai, A. H.; and Elsiesy, H.\n\n\n \n\n\n\n The American Journal of Case Reports, 19: 523–526. May 2018.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{alsebayel_congenital_2018,\n\ttitle = {Congenital {Esophageal} {Atresia} and {Microtia} in a {Newborn} {Secondary} to {Mycophenolate} {Mofetil} {Exposure} {During} {Pregnancy}: {A} {Case} {Report} and {Review} of the {Literature}},\n\tvolume = {19},\n\tissn = {1941-5923},\n\tshorttitle = {Congenital {Esophageal} {Atresia} and {Microtia} in a {Newborn} {Secondary} to {Mycophenolate} {Mofetil} {Exposure} {During} {Pregnancy}},\n\tdoi = {10.12659/AJCR.908433},\n\tabstract = {BACKGROUND Mycophenolate mofetil (MMF) is one of the most commonly prescribed drugs to prevent organ transplant rejection in combination with calcineurin inhibitors and steroids. It has a different toxicity profile than tacrolimus and cyclosporine.  Gastrointestinal tract disturbances are the most common adverse effects. The use of MMF in pregnant women, however, holds great risk of miscarriage and fetal development defects such as external ear malformation, ocular anomalies, cleft lip and palate, and abnormality of distal limbs, heart, esophagus, and kidneys. Based on post-marketing studies, its pregnancy category was reclassified as category D by the US FDA in 2007. CASE REPORT A 20-year-old woman received a deceased-donor liver transplant for end-stage liver disease secondary to autoimmune hepatitis. She had 3 miscarriages while on MMF. In her fourth pregnancy she was exposed to MMF in the first trimester, which was stopped by week 20 of the pregnancy. Obstetric ultrasound suggested a cephalic presentation fetus with abdominal circumference. Her pregnancy resulted in an infant with tracheoesophageal fistula, esophageal atresia, and a bilateral ear canal atresia (microtia) with normal sensorineural conduction. There were no other congenital abnormalities. Thoracoscopic ligation of fistula and thoracotomy with esophageal repair were performed and a bone-anchored hearing aid for conductive hearing loss was implanted. Here, we report a case of congenital esophageal atresia and microtia secondary to mycophenolate mofetil. CONCLUSIONS MMF should be avoided during pregnancy. Transplanted female patients of reproductive age should receive appropriate counseling.},\n\tlanguage = {eng},\n\tjournal = {The American Journal of Case Reports},\n\tauthor = {Alsebayel, Musaed Mohammed and Abaalkhail, Faisal Abdulrahman and Alsebayel, Faisal Mohammed and Alissa, Dema A. and Al-Jedai, Ahmed Hamdan and Elsiesy, Hussien},\n\tmonth = may,\n\tyear = {2018},\n\tpmid = {29720579},\n\tpmcid = {PMC5952718},\n\tkeywords = {Congenital Microtia, Enzyme Inhibitors, Esophageal Atresia, Female, Humans, Infant, Newborn, Liver Transplantation, Maternal-Fetal Exchange, Mycophenolic Acid, Pregnancy, Transplant Recipients},\n\tpages = {523--526},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Trends in congenital anomalies in Europe from 1980 to 2012.\n \n \n \n\n\n \n Morris, J. K.; Springett, A. L.; Greenlees, R.; Loane, M.; Addor, M.; Arriola, L.; Barisic, I.; Bergman, J. E. H.; Csaky-Szunyogh, M.; Dias, C.; Draper, E. S.; Garne, E.; Gatt, M.; Khoshnood, B.; Klungsoyr, K.; Lynch, C.; McDonnell, R.; Nelen, V.; Neville, A. J.; O'Mahony, M.; Pierini, A.; Queisser-Luft, A.; Randrianaivo, H.; Rankin, J.; Rissmann, A.; Kurinczuk, J.; Tucker, D.; Verellen-Dumoulin, C.; Wellesley, D.; and Dolk, H.\n\n\n \n\n\n\n PloS One, 13(4): e0194986. 2018.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{morris_trends_2018,\n\ttitle = {Trends in congenital anomalies in {Europe} from 1980 to 2012},\n\tvolume = {13},\n\tissn = {1932-6203},\n\tdoi = {10.1371/journal.pone.0194986},\n\tabstract = {BACKGROUND: Surveillance of congenital anomalies is important to identify potential teratogens.\nMETHODS: This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models.\nRESULTS: Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing.\nCONCLUSIONS: The annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4\\% (95\\% CI: 0.7\\% to 2.0\\%), 4.6\\% (1.0\\% to 8.2\\%), 3.4\\% (1.3\\% to 5.5\\%) and 4.1\\% (2.4\\% to 5.7\\%) respectively may reflect increases in maternal obesity and diabetes (known risk factors). The increased prevalence of cystic adenomatous malformation of the lung [6.5\\% (3.5\\% to 9.4\\%)] and decreased prevalence of limb reduction defects [-2.8\\% (-4.2\\% to -1.5\\%)] are unexplained. For renal dysplasia and maternal infections, increasing trends may be explained by increased screening, and deceases in patent ductus arteriosus at term and increases in craniosynostosis, by improved follow up period after birth and improved diagnosis. For oesophageal atresia, duodenal atresia/stenosis and ano-rectal atresia/stenosis recent changes in prevalence appeared incidental when compared with larger long term fluctuations. For microcephaly and congenital hydronephrosis trends could not be interpreted due to discrepancies in diagnostic criteria. The trends for club foot and syndactyly disappeared once registries with disparate results were excluded. No decrease in neural tube defects was detected, despite efforts at prevention through folic acid supplementation.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {PloS One},\n\tauthor = {Morris, Joan K. and Springett, Anna L. and Greenlees, Ruth and Loane, Maria and Addor, Marie-Claude and Arriola, Larraitz and Barisic, Ingeborg and Bergman, Jorieke E. H. and Csaky-Szunyogh, Melinda and Dias, Carlos and Draper, Elizabeth S. and Garne, Ester and Gatt, Miriam and Khoshnood, Babak and Klungsoyr, Kari and Lynch, Catherine and McDonnell, Robert and Nelen, Vera and Neville, Amanda J. and O'Mahony, Mary and Pierini, Anna and Queisser-Luft, Annette and Randrianaivo, Hanitra and Rankin, Judith and Rissmann, Anke and Kurinczuk, Jennifer and Tucker, David and Verellen-Dumoulin, Christine and Wellesley, Diana and Dolk, Helen},\n\tyear = {2018},\n\tpmid = {29621304},\n\tpmcid = {PMC5886482},\n\tkeywords = {Congenital Abnormalities, Europe, Female, History, 20th Century, History, 21st Century, Humans, Male, Population Surveillance, Pregnancy, Prevalence, Registries},\n\tpages = {e0194986},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Impact of Esophageal Atresia on the Success of Fundoplication for Gastroesophageal Reflux.\n \n \n \n\n\n \n Pellegrino, S. A.; King, S. K.; McLeod, E.; Hawley, A.; Brooks, J.; Hutson, J. M.; and Teague, W. J.\n\n\n \n\n\n\n The Journal of Pediatrics, 198: 60–66. July 2018.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{pellegrino_impact_2018,\n\ttitle = {Impact of {Esophageal} {Atresia} on the {Success} of {Fundoplication} for {Gastroesophageal} {Reflux}},\n\tvolume = {198},\n\tissn = {1097-6833},\n\tdoi = {10.1016/j.jpeds.2018.02.059},\n\tabstract = {OBJECTIVES: Fundoplication is commonly performed in patients with a history of esophageal atresia (EA), however, the success of this surgery is reduced, as reflected by an increased rate of redo fundoplication. We aimed to determine whether EA impacts the prevalence of fundoplication, its timing, and performance of a redo operation.\nSTUDY DESIGN: A single-center, retrospective review of all patients undergoing fundoplication over a 20-year period (1994-2013) was performed. Redo fundoplication was used as a surrogate for surgical failure.\nRESULTS: A total of 767 patients (patients with EA 85, those who did not have EA 682) underwent fundoplication during the study period. Median age (months) at primary fundoplication was lower in patients with EA (7.2 vs those who did not have EA 23.3; P {\\textless} .001). Redo fundoplication rates between groups were not significantly different (EA 11/85 vs 53/682; P = .14). Median time (months) between primary and redo fundoplication was greater in patients with EA (36.2 vs 11.7; P = .03).\nCONCLUSIONS: Contrary to popular belief, the incidence of redo fundoplication was not significantly increased in patients with a history of EA. However, patients with EA underwent fundoplication at younger ages, which may be related to early life-threatening events in these patients. These results inform perioperative counseling, and highlight the importance of sustained surgical follow-up in patients with EA.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Pellegrino, Samantha A. and King, Sebastian K. and McLeod, Elizabeth and Hawley, Alisa and Brooks, Jo-Anne and Hutson, John M. and Teague, Warwick J.},\n\tmonth = jul,\n\tyear = {2018},\n\tpmid = {29628411},\n\tkeywords = {Child, Preschool, Esophageal Atresia, Female, Follow-Up Studies, Fundoplication, Gastroesophageal Reflux, Humans, Infant, Laparoscopy, Male, Reoperation, Retrospective Studies, Treatment Outcome, esophageal atresia, fundoplication, gastroesophageal reflux, postoperative complication},\n\tpages = {60--66},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Endoscopic Electrocautery Incisional Therapy as a Treatment for Refractory Benign Pediatric Esophageal Strictures.\n \n \n \n\n\n \n Manfredi, M. A.; Clark, S. J.; Medford, S.; Staffa, S. J.; Ngo, P. D.; Hamilton, T. E.; Smithers, C. J.; and Jennings, R. W.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 67(4): 464–468. October 2018.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{manfredi_endoscopic_2018,\n\ttitle = {Endoscopic {Electrocautery} {Incisional} {Therapy} as a {Treatment} for {Refractory} {Benign} {Pediatric} {Esophageal} {Strictures}},\n\tvolume = {67},\n\tissn = {1536-4801},\n\tdoi = {10.1097/MPG.0000000000002008},\n\tabstract = {BACKGROUND AND AIM: Refractory esophageal strictures are rare conditions in pediatrics, and are often due to anastomotic, congenital, or caustic strictures. Traditional treatment options include serial dilation and surgical stricture resection; endoscopic intralesional steroid injections, mitomycin C, and externally removable stents combined with dilation have had variable success rates. Although not as widely used, endoscopic electrocautery incisional therapy (EIT) has been reported as an alternative treatment for refractory strictures in a small number of adult series. The aim of the study was to evaluate the safety and efficacy of EIT in a pediatric population with refractory esophageal strictures.\nMETHODS: A retrospective chart review was conducted on all patients who underwent EIT for esophageal strictures (May 2011-September 2017) at our tertiary-care referral center. A total of 57 patients underwent EIT. Procedural success was defined as no stricture resection, appropriate diameter for age, and fewer than 7 dilations within 24 months of first EIT session. This corresponded to the 90th percentile of the observed number of dilations in the data. All patients included in the study had at least 2-year follow-up.\nRESULTS: A total of 133 EIT sessions on 58 distinct anastomotic strictures were performed on 57 patients (24 girls). The youngest patient to have EIT was 3 months old and 4.8 kg. There were 36 strictures that met the criteria for refractory stricture and 22 non-refractory (NR) strictures. The median number of dilations before EIT therapy was 8 (interquartile range [IQR]: 6-10) in the refractory group and 3 (IQR: 0-3) in the NR group. In the refractory group, 61\\% of the patients met the criteria for treatment success. The median number of dilations within 2 years of EIT in the refractory group was 2 (IQR: 0-4). In the NR group, 100\\% of the patients met criteria for success. The median number of dilations within 2 years of EIT in the NR was 1 (IQR: 0-2). The overall adverse event rate was 5.3\\% (7/133), with 3 major (2.3\\%) and 4 minor events (3\\%).\nCONCLUSIONS: EIT shows promise as an adjunct treatment option for pediatric refractory esophageal strictures and may be considered before surgical resection even in severe cases. The complication rate, albeit low, is significant, and EIT should only be considered by experienced endoscopists in close consultation with surgery. Further prospective longitudinal studies are needed to validate this treatment.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Manfredi, Michael A. and Clark, Susannah J. and Medford, Shawn and Staffa, Steven J. and Ngo, Peter D. and Hamilton, Thomas E. and Smithers, C. Jason and Jennings, Russell W.},\n\tmonth = oct,\n\tyear = {2018},\n\tpmid = {29697549},\n\tkeywords = {Child, Child, Preschool, Electrocoagulation, Esophageal Stenosis, Esophagoscopy, Female, Humans, Infant, Male, Postoperative Complications, Retrospective Studies, Treatment Outcome},\n\tpages = {464--468},\n}\n\n\n\n\n\n\n\n

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\n BACKGROUND AND AIM: Refractory esophageal strictures are rare conditions in pediatrics, and are often due to anastomotic, congenital, or caustic strictures. Traditional treatment options include serial dilation and surgical stricture resection; endoscopic intralesional steroid injections, mitomycin C, and externally removable stents combined with dilation have had variable success rates. Although not as widely used, endoscopic electrocautery incisional therapy (EIT) has been reported as an alternative treatment for refractory strictures in a small number of adult series. The aim of the study was to evaluate the safety and efficacy of EIT in a pediatric population with refractory esophageal strictures. METHODS: A retrospective chart review was conducted on all patients who underwent EIT for esophageal strictures (May 2011-September 2017) at our tertiary-care referral center. A total of 57 patients underwent EIT. Procedural success was defined as no stricture resection, appropriate diameter for age, and fewer than 7 dilations within 24 months of first EIT session. This corresponded to the 90th percentile of the observed number of dilations in the data. All patients included in the study had at least 2-year follow-up. RESULTS: A total of 133 EIT sessions on 58 distinct anastomotic strictures were performed on 57 patients (24 girls). The youngest patient to have EIT was 3 months old and 4.8 kg. There were 36 strictures that met the criteria for refractory stricture and 22 non-refractory (NR) strictures. The median number of dilations before EIT therapy was 8 (interquartile range [IQR]: 6-10) in the refractory group and 3 (IQR: 0-3) in the NR group. In the refractory group, 61% of the patients met the criteria for treatment success. The median number of dilations within 2 years of EIT in the refractory group was 2 (IQR: 0-4). In the NR group, 100% of the patients met criteria for success. The median number of dilations within 2 years of EIT in the NR was 1 (IQR: 0-2). The overall adverse event rate was 5.3% (7/133), with 3 major (2.3%) and 4 minor events (3%). CONCLUSIONS: EIT shows promise as an adjunct treatment option for pediatric refractory esophageal strictures and may be considered before surgical resection even in severe cases. The complication rate, albeit low, is significant, and EIT should only be considered by experienced endoscopists in close consultation with surgery. Further prospective longitudinal studies are needed to validate this treatment.\n

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\n \n\n \n \n \n \n \n Radiation Exposure and Attributable Cancer Risk in Patients With Esophageal Atresia.\n \n \n \n\n\n \n Yousef, Y.; and Baird, R.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 66(2): 234–238. February 2018.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{yousef_radiation_2018,\n\ttitle = {Radiation {Exposure} and {Attributable} {Cancer} {Risk} in {Patients} {With} {Esophageal} {Atresia}},\n\tvolume = {66},\n\tissn = {1536-4801},\n\tdoi = {10.1097/MPG.0000000000001701},\n\tabstract = {OBJECTIVES: Cases of esophageal carcinoma have been documented in survivors of esophageal atresia (EA). Children with EA undergo considerable amounts of diagnostic imaging and consequent radiation exposure potentially increasing their lifetime cancer mortality risk. This study evaluates the radiological procedures performed on patients with EA and estimates their cumulative radiation exposure and attributable lifetime cancer mortality risk.\nMETHODS: Medical records of patients with EA managed at a tertiary care center were reviewed for demographics, EA subtype, and number and type of radiological investigations. Existing normative data were used to estimate the cumulative radiation exposure and lifetime cancer risk per patient.\nRESULTS: The present study included 53 patients with a mean follow-up of 5.7 years. The overall median and maximum estimated effective radiation dose in the neonatal period was 5521.4 μSv/patient and 66638.6 μSv/patient, respectively. This correlates to a median and maximum estimated cumulative lifetime cancer mortality risk of 1:1530 and 1:130, respectively. Hence, radiation exposure in the neonatal period increased the cumulative cancer mortality risk a median of 130-fold and a maximum of 1575-fold in EA survivors.\nCONCLUSIONS: Children with EA are exposed to significant amounts of radiation and an increased estimated cumulative cancer mortality risk. Efforts should be made to eliminate superfluous imaging.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Yousef, Yasmine and Baird, Robert},\n\tmonth = feb,\n\tyear = {2018},\n\tpmid = {28753184},\n\tkeywords = {Esophageal Atresia, Esophageal Neoplasms, Female, Humans, Infant, Newborn, Male, Radiation Dosage, Radiation Exposure, Retrospective Studies, Risk Assessment, Risk Factors},\n\tpages = {234--238},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n The Case for Thoughtful Prescribing of Proton Pump Inhibitors in Infants.\n \n \n \n \n\n\n \n Rosen, R. L.; Krishnan, U.; Mousa, H.; Dall'oglio, L.; Faure, C.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 66(1): e26–e27. January 2018.\n \n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{rosen_case_2018,\n\ttitle = {The {Case} for {Thoughtful} {Prescribing} of {Proton} {Pump} {Inhibitors} in {Infants}},\n\tvolume = {66},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/29045354/},\n\tdoi = {10.1097/MPG.0000000000001794},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Rosen, Rachel L. and Krishnan, Usha and Mousa, Hayat and Dall'oglio, Luigi and Faure, Christophe and Gottrand, Frederic},\n\tmonth = jan,\n\tyear = {2018},\n\tpmid = {29045354},\n\tpmcid = {PMC5765768},\n\tkeywords = {Drug Prescriptions, Gastroesophageal Reflux, Humans, Infant, Proton Pump Inhibitors},\n\tpages = {e26--e27},\n}\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Management and outcome of neonates with a prenatal diagnosis of esophageal atresia type A: A population-based study.\n \n \n \n \n\n\n \n Garabedian, C.; Bonnard, A.; Rousseau, V.; Sfeir, R.; CRACMO; Drumez, E.; Michaud, L.; Gottrand, F.; and Houfflin-Debarge, V.\n\n\n \n\n\n\n Prenatal Diagnosis, 38(7): 517–522. June 2018.\n \n\n\n\n
\n\n\n\n \n \n $\"Management$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{garabedian_management_2018,\n\ttitle = {Management and outcome of neonates with a prenatal diagnosis of esophageal atresia type {A}: {A} population-based study},\n\tvolume = {38},\n\tissn = {1097-0223},\n\tshorttitle = {Management and outcome of neonates with a prenatal diagnosis of esophageal atresia type {A}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/29739032/},\n\tdoi = {10.1002/pd.5273},\n\tabstract = {OBJECTIVE: Evaluate the neonatal management and outcomes of neonates with prenatal diagnosis of esophageal atresia (EA) type A.\nMETHODS: This population-based study was conducted using data from the French National Register for infants with EA born from 2008 to 2014, including all cases of EA type A. We compared prenatal and neonatal characteristics and outcomes in children with prenatal diagnosis of EA type A with those with a postnatal diagnosis until the age of 1.\nRESULTS: A total of 1118 live births with EA were recorded among which 88 (7.9\\%) were EA type A. Prenatal diagnoses were performed in 75 cases (85.2\\%), and counselling with a prenatal specialist was conducted in 84.8\\% of the prenatal group. Still within that group, the gestational age at delivery was significantly higher than in the postnatal group (36 [35-38] versus 34 [32-36] weeks; P = .048). Inborn births were more frequent in the prenatal group (86.1\\% vs 7.7\\%, P {\\textless} .0001), and mortality and outcome were similar in both groups.\nCONCLUSION: Prenatal diagnosis is high in EA type A, which enables to offer an antenatal parental counseling and which avoids postnatal transfers. Prognosis of EA types A does not appear to be influenced by the prenatal diagnosis.},\n\tlanguage = {eng},\n\tnumber = {7},\n\tjournal = {Prenatal Diagnosis},\n\tauthor = {Garabedian, C. and Bonnard, A. and Rousseau, V. and Sfeir, R. and {CRACMO} and Drumez, E. and Michaud, L. and Gottrand, F. and Houfflin-Debarge, V.},\n\tmonth = jun,\n\tyear = {2018},\n\tpmid = {29739032},\n\tkeywords = {Esophageal Atresia, France, Humans, Infant, Newborn, Prenatal Diagnosis, Registries},\n\tpages = {517--522},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Influence of Percutaneous Endoscopic Gastrostomy on Gastroesophageal Reflux Disease in Children.\n \n \n \n \n\n\n \n Aumar, M.; Lalanne, A.; Guimber, D.; Coopman, S.; Turck, D.; Michaud, L.; and Gottrand, F.\n\n\n \n\n\n\n The Journal of Pediatrics, 197: 116–120. June 2018.\n \n\n\n\n
\n\n\n\n \n \n $\"Influence$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{aumar_influence_2018,\n\ttitle = {Influence of {Percutaneous} {Endoscopic} {Gastrostomy} on {Gastroesophageal} {Reflux} {Disease} in {Children}},\n\tvolume = {197},\n\tissn = {1097-6833},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/29655862/},\n\tdoi = {10.1016/j.jpeds.2018.02.003},\n\tabstract = {OBJECTIVE: To determine if gastroesophageal reflux disease (GERD) is present at long-term follow-up after percutaneous endoscopic gastrostomy (PEG), and to identify factors associated with the occurrence or aggravation of GERD after PEG placement.\nSTUDY DESIGN: This prospective, observational study was conducted in our single tertiary center over a 13-year period (gastrostomy performed from 1990 to 2003 and follow-up to 2015). Every child who underwent PEG in our center (N = 368) from 1990 to 2003 was eligible. GERD was defined by clinical manifestations requiring antisecretory or prokinetic treatment, occurrence of a GERD-related complication, or the need for antireflux surgery. Outcomes among patients without antireflux surgery were also assessed. Multivariate analysis was used to identify factors aggravating GERD after PEG placement.\nRESULTS: A total 326 patients (89\\%; 56\\% with a neurologic impairment) were studied with a median follow-up after 3.5 years (range, 2.0-13.5 years). After PEG placement, GERD appeared in 11\\% of patients and was aggravated in 25\\% of patients with preexisting GERD. Factors associated with GERD worsening after PEG placement were neurologic impairment and preexisting GERD. Only 53 patients (16\\%) required antireflux surgery, among whom 22 required surgery in the year after PEG. Neurologic impairment was the only factor significantly associated with the need for antireflux surgery.\nCONCLUSIONS: GERD predominantly remains clinically controlled after PEG placement. Routine antireflux surgery at the time of PEG placement is not justified.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Aumar, Madeleine and Lalanne, Arnaud and Guimber, Dominique and Coopman, Stéphanie and Turck, Dominique and Michaud, Laurent and Gottrand, Frédéric},\n\tmonth = jun,\n\tyear = {2018},\n\tpmid = {29655862},\n\tkeywords = {Adolescent, Adult, Child, Child, Preschool, Female, Follow-Up Studies, France, Gastroesophageal Reflux, Gastroscopy, Gastrostomy, Humans, Incidence, Infant, Male, Postoperative Complications, Prospective Studies, Retrospective Studies, Risk Factors, Young Adult},\n\tpages = {116--120},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Position Paper of INoEA Working Group on Long-Gap Esophageal Atresia: For Better Care.\n \n \n \n \n\n\n \n van der Zee, D. C.; Bagolan, P.; Faure, C.; Gottrand, F.; Jennings, R.; Laberge, J.; Martinez Ferro, M. H.; Parmentier, B.; Sfeir, R.; and Teague, W.\n\n\n \n\n\n\n Frontiers in Pediatrics, 5: 63. 2017.\n \n\n\n\n
\n\n\n\n \n \n $\"Position$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{van_der_zee_position_2017,\n\ttitle = {Position {Paper} of {INoEA} {Working} {Group} on {Long}-{Gap} {Esophageal} {Atresia}: {For} {Better} {Care}},\n\tvolume = {5},\n\tissn = {2296-2360},\n\tshorttitle = {Position {Paper} of {INoEA} {Working} {Group} on {Long}-{Gap} {Esophageal} {Atresia}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/28409148/},\n\tdoi = {10.3389/fped.2017.00063},\n\tabstract = {INoEA is the International Network of Esophageal Atresia and consists of a broad spectrum of pediatric specialties and patient societies. The working group on long-gap esophageal atresia (LGEA) set out to develop guidelines regarding the definition of LGEA, the best diagnostic and treatment strategies, and highlight the necessity of experience and communication in the management of these challenging patients. Review of the literature and expert discussion concluded that LGEA should be defined as any esophageal atresia (EA) that has no intra-abdominal air, realizing that this defines EA with no distal tracheoesophageal fistula (TEF). LGEA is considerably more complex than EA with distal TEFs and should be referred to a center of expertise. The first choice is to preserve the native esophagus and pursue primary repair, delayed primary anastomosis, or traction/growth techniques to achieve anastomosis. A cervical esophagostomy should be avoided if possible. Only if primary anastomosis is not possible, replacement techniques should be used. Jejunal interposition is proposed as the best option among the major EA centers. In light of the infrequent occurrence of LGEA and the technically demanding techniques involved to achieve esophageal continuity, it is strongly advised to develop regional or national centers of expertise for the management and follow-up of these very complex patients.},\n\tlanguage = {eng},\n\tjournal = {Frontiers in Pediatrics},\n\tauthor = {van der Zee, David C. and Bagolan, Pietro and Faure, Christophe and Gottrand, Frederic and Jennings, Russell and Laberge, Jean-Martin and Martinez Ferro, Marcela Hernan and Parmentier, Benoît and Sfeir, Rony and Teague, Warwick},\n\tyear = {2017},\n\tpmid = {28409148},\n\tpmcid = {PMC5374143},\n\tkeywords = {centers of expertise, definition, diagnosis, long-gap esophageal atresia, management},\n\tpages = {63},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n Determinants of exercise capacity in school-aged esophageal atresia patients.\n \n \n \n\n\n \n Toussaint-Duyster, L. C. C.; van der Cammen-van Zijp, M. H. M.; Spoel, M.; Lam, M.; Wijnen, R. M. H.; de Jongste, J. C.; Tibboel, D.; van Rosmalen, J.; and IJsselstijn, H.\n\n\n \n\n\n\n Pediatric Pulmonology, 52(9): 1198–1205. September 2017.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{toussaint-duyster_determinants_2017,\n\ttitle = {Determinants of exercise capacity in school-aged esophageal atresia patients},\n\tvolume = {52},\n\tissn = {1099-0496},\n\tdoi = {10.1002/ppul.23687},\n\tabstract = {BACKGROUND AND AIMS: Data on long-term outcome of exercise capacity in school-aged children with esophageal atresia (EA) are scarce. We evaluated maximal exercise capacity and its relation to lung function. Moreover, we studied other possible determinants of exercise capacity and lung function.\nMETHODS: Exercise capacity of 63 children with EA born 1999-2007 was evaluated at the age of 8 years with the Bruce-protocol. Dynamic and static lung volumes, bronchodilator response and diffusion capacity were measured. Furthermore, perinatal characteristics, hospital admissions for lower respiratory tract infections (RTIs), RTIs treated with antibiotics in the past year, symptoms of gastroesophageal reflux, weight-for-height, and sports participation were evaluated as other potential determinants.\nRESULTS: Exercise capacity was significantly below normal: mean (SD) SDS -0.91 (0.97); P {\\textless} 0.001. All spirometric parameters were significantly below normal with significant reversibility of airflow obstruction in 13.5\\% of patients. Static lung volumes were significantly decreased (mean (SD) SDS TLChe -1.06 (1.29); P {\\textless} 0.001). Diffusion capacity corrected for alveolar volume was normal (mean (SD) SDS KCO -0.12 (1.04)). Exercise capacity was positively associated with total lung capacity and negatively with SDS weight-for-height. Spirometric parameters were negatively associated with congenital cardiac malformation, duration of ventilation, and persistent respiratory morbidity.\nCONCLUSION: Eight-year-old children with EA had reduced exercise capacity which was only associated with the reduction in TLChe and higher SDS weight-for-height. We speculate that diminished physical activity with recurrent respiratory tract infections may also play a role in reduced exercise capacity. This should be subject to further research to optimize appropriate intervention.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Pediatric Pulmonology},\n\tauthor = {Toussaint-Duyster, Leontien C. C. and van der Cammen-van Zijp, Monique H. M. and Spoel, Marjolein and Lam, Mhanfei and Wijnen, Rene M. H. and de Jongste, Johan C. and Tibboel, Dick and van Rosmalen, Joost and IJsselstijn, Hanneke},\n\tmonth = sep,\n\tyear = {2017},\n\tpmid = {28244688},\n\tkeywords = {Anti-Bacterial Agents, Bronchodilator Agents, Child, Esophageal Atresia, Exercise, Exercise Test, Female, Gastroesophageal Reflux, Humans, Lung, Male, Respiratory Tract Infections, Spirometry, Total Lung Capacity, congenital malformations, esophageal atresia, exercise capacity, pulmonary function testing, respiratory tract infections, school-aged children},\n\tpages = {1198--1205},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Longitudinal evaluation of growth in oesophageal atresia patients up to 12 years.\n \n \n \n\n\n \n Vergouwe, F. W. T.; Spoel, M.; van Beelen, N. W. G.; Gischler, S. J.; Wijnen, R. M. H.; van Rosmalen, J.; and IJsselstijn, H.\n\n\n \n\n\n\n Archives of Disease in Childhood. Fetal and Neonatal Edition, 102(5): F417–F422. September 2017.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{vergouwe_longitudinal_2017,\n\ttitle = {Longitudinal evaluation of growth in oesophageal atresia patients up to 12 years},\n\tvolume = {102},\n\tissn = {1468-2052},\n\tdoi = {10.1136/archdischild-2016-311598},\n\tabstract = {OBJECTIVE: Previous studies reported diminished growth after oesophageal atresia (OA) repair. We evaluated long-term follow-up data on growth.\nMETHODS: Longitudinal cohort study up to 12 years. Patients with OA, born 1999-2013, who participated in a longitudinal follow-up programme were included. Children with genetic syndromes associated with growth disorders were excluded. SD scores (SDS) for height-for-age (HFA), weight-for-height (WFH) and distance-to-target-height were calculated for routine visits (0.5/1/2/5/8/12 years). Linear mixed models were used to estimate SDS until 12 years of age and to evaluate explanatory factors for growth.\nRESULTS: We included 126/155 children (32\\% prematurely born, 20\\% small for gestational age), 32 reached the age of 12 years. Fundoplication surgery was performed in 24\\%. SDS-HFA was below normal up to 8 years but improved over these years (mean (SE) -0.48 (0.09), -0.31 (0.09) and -0.20 (0.13) at 0.5, 8 and 12 years). Scores improved after correction for target height (mean (SE) -0.29 (0.10), -0.17 (0.09) and -0.10 (0.14) at 0.5, 8 and 12 years). SDS-WFH was below normal from age 1-5 years (mean (SE) -0.53 (0.09), -0.24 (0.09) and 0.03 (0.14) at 1, 5 and 12 years). Low birth weight and fundoplication surgery were negatively associated with growth.\nCONCLUSIONS: The growth of patients with OA was below the reference norm during the first years of life, but normalised at 12 years. Large longitudinal cohort studies should evaluate if normal growth persists into adolescence. Early nutritional assessment with timely dietary intervention should be considered especially in those with low birth weight or following fundoplication surgery.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Archives of Disease in Childhood. Fetal and Neonatal Edition},\n\tauthor = {Vergouwe, Floor W. T. and Spoel, Marjolein and van Beelen, Nicole W. G. and Gischler, Saskia J. and Wijnen, René M. H. and van Rosmalen, Joost and IJsselstijn, Hanneke},\n\tmonth = sep,\n\tyear = {2017},\n\tpmid = {28292964},\n\tkeywords = {Body Height, Body Weight, Child, Child Development, Cohort Studies, Esophageal Atresia, Female, Fundoplication, Growth, Humans, Infant, Low Birth Weight, Infant, Newborn, Linear Models, Longitudinal Studies, Male, Malnutrition, Netherlands, Oesophageal atresia, Outcome, Reference Values, Risk factors},\n\tpages = {F417--F422},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Endoscopic management of Barrett's esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.\n \n \n \n\n\n \n Weusten, B.; Bisschops, R.; Coron, E.; Dinis-Ribeiro, M.; Dumonceau, J.; Esteban, J.; Hassan, C.; Pech, O.; Repici, A.; Bergman, J.; and di Pietro, M.\n\n\n \n\n\n\n Endoscopy, 49(2): 191–198. February 2017.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{weusten_endoscopic_2017,\n\ttitle = {Endoscopic management of {Barrett}'s esophagus: {European} {Society} of {Gastrointestinal} {Endoscopy} ({ESGE}) {Position} {Statement}},\n\tvolume = {49},\n\tissn = {1438-8812},\n\tshorttitle = {Endoscopic management of {Barrett}'s esophagus},\n\tdoi = {10.1055/s-0042-122140},\n\tabstract = {Current practices for the management of Barrett's esophagus (BE) vary across Europe, as several national European guidelines exist. This Position Statement from the European Society of Gastrointestinal Endoscopy (ESGE) is an attempt to homogenize recommendations and, hence, patient management according to the best scientific evidence and other considerations (e.g. health policy). A Working Group developed consensus statements, using the existing national guidelines as a starting point and considering new evidence in the literature. The Position Statement wishes to contribute to a more cost-effective approach to the care of patients with BE by reducing the number of surveillance endoscopies for patients with a low risk of malignant progression and centralizing care in expert centers for those with high progression rates.Main statements MS1 The diagnosis of BE is made if the distal esophagus is lined with columnar epithelium with a minimum length of 1 cm (tongues or circular) containing specialized intestinal metaplasia at histopathological examination. MS2 The ESGE recommends varying surveillance intervals for different BE lengths. For patients with an irregular Z-line/columnar-lined esophagus of {\\textless} 1 cm, no routine biopsies or endoscopic surveillance is advised. For BE ≥ 1 cm and {\\textless} 3 cm, BE surveillance should be repeated every 5 years. For BE ≥ 3 cm and {\\textless} 10 cm, the interval for endoscopic surveillance should be 3 years. Patients with BE with a maximum extent ≥ 10 cm should be referred to a BE expert center for surveillance endoscopies. Patients with limited life expectancy and advanced age should be discharged from endoscopic surveillance. MS3 The diagnosis of any degree of dysplasia (including "indefinite for dysplasia") in BE requires confirmation by an expert gastrointestinal pathologist. MS4 Patients with visible lesions in BE diagnosed as dysplasia or early cancer should be referred to a BE expert center. All visible abnormalities, regardless of the degree of dysplasia, should be removed by means of endoscopic resection techniques in order to obtain optimal histopathological staging MS5 All patients with a BE ≥ 10 cm, a confirmed diagnosis of low grade dysplasia, high grade dysplasia (HGD), or early cancer should be referred to a BE expert center for surveillance and/or treatment. BE expert centers should meet the following criteria: annual case load of ≥10 new patients undergoing endoscopic treatment for HGD or early carcinoma per BE expert endoscopist; endoscopic and histological care provided by endoscopists and pathologists who have followed additional training; at least 30 supervised endoscopic resection and 30 endoscopic ablation procedures to acquire competence in technical skills, management pathways, and complications; multidisciplinary meetings with gastroenterologists, surgeons, oncologists, and pathologists to discuss patients with Barrett's neoplasia; access to experienced esophageal surgery; and all BE patients registered prospectively in a database.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Endoscopy},\n\tauthor = {Weusten, Bas and Bisschops, Raf and Coron, Emanuel and Dinis-Ribeiro, Mário and Dumonceau, Jean-Marc and Esteban, José-Miguel and Hassan, Cesare and Pech, Oliver and Repici, Alessandro and Bergman, Jacques and di Pietro, Massimiliano},\n\tmonth = feb,\n\tyear = {2017},\n\tpmid = {28122386},\n\tkeywords = {Barrett Esophagus, Consensus, Endoscopy, Gastrointestinal, Europe, Humans, Patient Care Management, Practice Guidelines as Topic, Societies, Medical},\n\tpages = {191--198},\n}\n\n\n\n\n\n\n\n

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\n Current practices for the management of Barrett's esophagus (BE) vary across Europe, as several national European guidelines exist. This Position Statement from the European Society of Gastrointestinal Endoscopy (ESGE) is an attempt to homogenize recommendations and, hence, patient management according to the best scientific evidence and other considerations (e.g. health policy). A Working Group developed consensus statements, using the existing national guidelines as a starting point and considering new evidence in the literature. The Position Statement wishes to contribute to a more cost-effective approach to the care of patients with BE by reducing the number of surveillance endoscopies for patients with a low risk of malignant progression and centralizing care in expert centers for those with high progression rates.Main statements MS1 The diagnosis of BE is made if the distal esophagus is lined with columnar epithelium with a minimum length of 1 cm (tongues or circular) containing specialized intestinal metaplasia at histopathological examination. MS2 The ESGE recommends varying surveillance intervals for different BE lengths. For patients with an irregular Z-line/columnar-lined esophagus of \\textless 1 cm, no routine biopsies or endoscopic surveillance is advised. For BE ≥ 1 cm and \\textless 3 cm, BE surveillance should be repeated every 5 years. For BE ≥ 3 cm and \\textless 10 cm, the interval for endoscopic surveillance should be 3 years. Patients with BE with a maximum extent ≥ 10 cm should be referred to a BE expert center for surveillance endoscopies. Patients with limited life expectancy and advanced age should be discharged from endoscopic surveillance. MS3 The diagnosis of any degree of dysplasia (including \"indefinite for dysplasia\") in BE requires confirmation by an expert gastrointestinal pathologist. MS4 Patients with visible lesions in BE diagnosed as dysplasia or early cancer should be referred to a BE expert center. All visible abnormalities, regardless of the degree of dysplasia, should be removed by means of endoscopic resection techniques in order to obtain optimal histopathological staging MS5 All patients with a BE ≥ 10 cm, a confirmed diagnosis of low grade dysplasia, high grade dysplasia (HGD), or early cancer should be referred to a BE expert center for surveillance and/or treatment. BE expert centers should meet the following criteria: annual case load of ≥10 new patients undergoing endoscopic treatment for HGD or early carcinoma per BE expert endoscopist; endoscopic and histological care provided by endoscopists and pathologists who have followed additional training; at least 30 supervised endoscopic resection and 30 endoscopic ablation procedures to acquire competence in technical skills, management pathways, and complications; multidisciplinary meetings with gastroenterologists, surgeons, oncologists, and pathologists to discuss patients with Barrett's neoplasia; access to experienced esophageal surgery; and all BE patients registered prospectively in a database.\n

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\n \n\n \n \n \n \n \n \n Circumferential Esophageal Replacement by a Tissue-engineered Substitute Using Mesenchymal Stem Cells: An Experimental Study in Mini Pigs.\n \n \n \n \n\n\n \n Catry, J.; Luong-Nguyen, M.; Arakelian, L.; Poghosyan, T.; Bruneval, P.; Domet, T.; Michaud, L.; Sfeir, R.; Gottrand, F.; Larghero, J.; Vanneaux, V.; and Cattan, P.\n\n\n \n\n\n\n Cell Transplantation, 26(12): 1831–1839. December 2017.\n \n\n\n\n
\n\n\n\n \n \n $\"Circumferential$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{catry_circumferential_2017,\n\ttitle = {Circumferential {Esophageal} {Replacement} by a {Tissue}-engineered {Substitute} {Using} {Mesenchymal} {Stem} {Cells}: {An} {Experimental} {Study} in {Mini} {Pigs}},\n\tvolume = {26},\n\tissn = {1555-3892},\n\tshorttitle = {Circumferential {Esophageal} {Replacement} by a {Tissue}-engineered {Substitute} {Using} {Mesenchymal} {Stem} {Cells}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/29390879/},\n\tdoi = {10.1177/0963689717741498},\n\tabstract = {Tissue engineering appears promising as an alternative technique for esophageal replacement. Mesenchymal stem cells (MSCs) could be of interest for esophageal regeneration. Evaluation of the ability of an acellular matrix seeded with autologous MSCs to promote tissue remodeling toward an esophageal phenotype after circumferential replacement of the esophagus in a mini pig model. A 3 cm long circumferential replacement of the abdominal esophagus was performed with an MSC-seeded matrix (MSC group, n = 10) versus a matrix alone (control group, n = 10), which has previously been matured into the great omentum. The graft area was covered with an esophageal removable stent. A comparative histological analysis of the graft area after animals were euthanized sequentially is the primary outcome of the study. Histological findings after maturation, overall animal survival, and postoperative morbidity were also compared between groups. At postoperative day 45 (POD 45), a mature squamous epithelium covering the entire surface of the graft area was observed in all the MSC group specimens but in none of the control group before POD 95. Starting at POD 45, desmin positive cells were seen in the graft area in the MSC group but never in the control group. There were no differences between groups in the incidence of surgical complications and postoperative death. In this model, MSCs accelerate the mature re-epitheliazation and early initiation of muscle cell colonization. Further studies will focus on the use of cell tracking tools in order to analyze the becoming of these cells and the mechanisms involved in this tissue regeneration.},\n\tlanguage = {eng},\n\tnumber = {12},\n\tjournal = {Cell Transplantation},\n\tauthor = {Catry, Jonathan and Luong-Nguyen, Minh and Arakelian, Lousineh and Poghosyan, Tigran and Bruneval, Patrick and Domet, Thomas and Michaud, Laurent and Sfeir, Rony and Gottrand, Frederic and Larghero, Jerome and Vanneaux, Valerie and Cattan, Pierre},\n\tmonth = dec,\n\tyear = {2017},\n\tpmid = {29390879},\n\tpmcid = {PMC5802636},\n\tkeywords = {Animals, Esophagus, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Swine, Swine, Miniature, Tissue Engineering, Tissue Scaffolds, acellular matrix, esophageal stenting, esophagus, large animal model, mesenchymal stem cells, tissue engineering, translational research},\n\tpages = {1831--1839},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Pilot Mindfulness Intervention for Children Born with Esophageal Atresia and Their Parents.\n \n \n \n \n\n\n \n Andreotti, E.; Antoine, P.; Hanafi, M.; Michaud, L.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Child and Family Studies, 26(5): 1432–1444. May 2017.\n \n\n\n\n
\n\n\n\n \n \n $\"Pilot$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{andreotti_pilot_2017,\n\ttitle = {Pilot {Mindfulness} {Intervention} for {Children} {Born} with {Esophageal} {Atresia} and {Their} {Parents}},\n\tvolume = {26},\n\tissn = {1573-2843},\n\turl = {https://doi.org/10.1007/s10826-017-0657-0},\n\tdoi = {10.1007/s10826-017-0657-0},\n\tabstract = {A pilot mindfulness home intervention was conducted for 6 weeks among 8–12-year-old children born with esophageal atresia and their parents. Participants were randomly assigned to a waiting list control (WLC) group (n = 8) and an experimental group (n = 12). When all participants had completed the mindfulness-based program, data were pooled and treated for the entire sample (n = 19). Self-assessment measures included the Mindful Attention Awareness Scale for Adolescents (MAAS-A), the Child and Adolescent Mindfulness Measure (CAMM), the modified Spielberger State-Trait Anxiety Inventory—Child (STAI-C), the Children’s Depression Inventory (CDI), and the Cognitive Emotion Regulation Questionnaire Kids version (CERQ-k). Parental assessment measures included the modified STAI-C. The results underlined the program’s feasibility and acceptability. Clinical effects of the mindfulness-based program were observed. Self-assessed data for children who had practiced mindfulness compared to the WLC group showed increased mindfulness and decreased depression. Reduced anxiety was found in all groups. Positive affect tended to improve from pre-test to post-test in children who had practiced mindfulness compared to the WLC group. Parental assessments showed significant improvement in positive affect and decreases in anxiety and negative affect in the intervention group compared to the WLC group. Cognitive emotion regulation strategies were also affected by the mindfulness-based program. Rumination scores significantly decreased from pre-test to post-test in the intervention group. This preliminary study suggests that regular mindfulness practice presents a promising approach to reducing the burden of this neonatal malformation.},\n\tlanguage = {en},\n\tnumber = {5},\n\turldate = {2024-08-21},\n\tjournal = {Journal of Child and Family Studies},\n\tauthor = {Andreotti, Eva and Antoine, Pascal and Hanafi, Manel and Michaud, Laurent and Gottrand, Fréderic},\n\tmonth = may,\n\tyear = {2017},\n\tkeywords = {Anxiety, Children, Depression, Emotion regulation, Medical Ethics, Mindfulness},\n\tpages = {1432--1444},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Intestinal Metaplasia of the Esophagus in Children With Esophageal Atresia.\n \n \n \n \n\n\n \n Hsieh, H.; Frenette, A.; Michaud, L.; Krishnan, U.; Dal-Soglio, D. B.; Gottrand, F.; and Faure, C.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 65(1): e1–e4. July 2017.\n \n\n\n\n
\n\n\n\n \n \n $\"Intestinal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{hsieh_intestinal_2017,\n\ttitle = {Intestinal {Metaplasia} of the {Esophagus} in {Children} {With} {Esophageal} {Atresia}},\n\tvolume = {65},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/28248794/},\n\tdoi = {10.1097/MPG.0000000000001558},\n\tabstract = {OBJECTIVES: Patients with esophageal atresia/tracheoesophageal fistula (EA-TEF) can develop Barrett esophagus as a long-term consequence of their condition. Intestinal metaplasia (IM), a risk factor for developing adenocarcinoma of the esophagus, has not been well characterized in the pediatric population.\nMETHODS: Retrospective review of patients with EA-TEF followed at 3 academic pediatric centers between the years 1997 and 2014.\nRESULTS: Among 542 children and adolescents, 1.3\\% (7 patients, 5 girls) were diagnosed with IM based on endoscopy and pathology. Six of the patients had EA-TEF type C, whereas the last patient had a "long gap" type A atresia. Patients were diagnosed with gastric metaplasia either before the IM diagnosis in 4 patients or concomitantly in 3. The median (range) age of diagnosis for gastric metaplasia was 7.9 (range 2-17.2) and for IM 10.9 (2-17.2) years. Gastroesophageal reflux (GER) symptoms were nonspecific. Five patients were on proton pump inhibitor therapy for symptomatic GER at the time of diagnosis of IM. 2 of the 7 patients had previously undergone Nissen fundoplication. One patient, who had undergone a Nissen fundoplication, was restarted on proton pump inhibitor once the diagnosis of IM was made. All patients had repeated endoscopy and dysplasia was not observed with a median follow-up of 1.7 (range 1-4.9) years.\nCONCLUSIONS: IM occurs in patients with EA-TEF, some as young as 2 years. Therefore, early endoscopic surveillance should be considered in this GER-prone population.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Hsieh, Helen and Frenette, Adam and Michaud, Laurent and Krishnan, Usha and Dal-Soglio, Dorothée B. and Gottrand, Frederic and Faure, Christophe},\n\tmonth = jul,\n\tyear = {2017},\n\tpmid = {28248794},\n\tkeywords = {Adolescent, Aftercare, Barrett Esophagus, Child, Child, Preschool, Esophageal Atresia, Esophagoscopy, Esophagus, Female, Follow-Up Studies, Gastroesophageal Reflux, Humans, Intestines, Male, Metaplasia, Retrospective Studies, Tracheoesophageal Fistula},\n\tpages = {e1--e4},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Importance of an International Registry for and Collaborative Research on Esophageal Atresia.\n \n \n \n \n\n\n \n Gottrand, F.; Ley, D.; Michaud, L.; and Sfeir, R.\n\n\n \n\n\n\n Frontiers in Pediatrics, 5: 81. 2017.\n \n\n\n\n
\n\n\n\n \n \n $\"Importance$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gottrand_importance_2017,\n\ttitle = {Importance of an {International} {Registry} for and {Collaborative} {Research} on {Esophageal} {Atresia}},\n\tvolume = {5},\n\tissn = {2296-2360},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/28473972/},\n\tdoi = {10.3389/fped.2017.00081},\n\tabstract = {Esophageal atresia (EA) is a rare congenital defect. Data on EA prevalence, management, and long-term outcome are lacking because the available data come from small retrospective series from tertiary referral centers. An international multicenter registry would provide strong epidemiological data from large population-based cohorts on EA prevalence and incidence, treatment, long-term morbidity, and prognosis and would thus provide accurate data for evaluation of the current guidelines for EA management. The future challenge of the new international network on EA, which was created in 2013, is to promote the creation of a collaborative database and further studies.},\n\tlanguage = {eng},\n\tjournal = {Frontiers in Pediatrics},\n\tauthor = {Gottrand, Frédéric and Ley, Delphine and Michaud, Laurent and Sfeir, Rony},\n\tyear = {2017},\n\tpmid = {28473972},\n\tpmcid = {PMC5397510},\n\tkeywords = {collaborative research, congenital defect, esophageal atresia, international registry, population-based cohort},\n\tpages = {81},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n How to Care for Patients with EA-TEF: The Known and the Unknown.\n \n \n \n \n\n\n \n Mousa, H.; Krishnan, U.; Hassan, M.; Dall'Oglio, L.; Rosen, R.; Gottrand, F.; and Faure, C.\n\n\n \n\n\n\n Current Gastroenterology Reports, 19(12): 65. November 2017.\n \n\n\n\n
\n\n\n\n \n \n $\"How$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{mousa_how_2017,\n\ttitle = {How to {Care} for {Patients} with {EA}-{TEF}: {The} {Known} and the {Unknown}},\n\tvolume = {19},\n\tissn = {1534-312X},\n\tshorttitle = {How to {Care} for {Patients} with {EA}-{TEF}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/29177550/},\n\tdoi = {10.1007/s11894-017-0605-6},\n\tabstract = {PURPOSE OF REVIEW: Guidelines were recently published highlighting why esophageal atresia (EA) patients are prone to complication risks, and the need for long-term follow-up. In this review, we will focus on how to investigate and treat potential complications, as well as the pros and cons of different investigative and treatment modalities, and what areas continue to need further research.\nRECENT FINDINGS: EA patients are at high risk for gastroesophageal reflux and esophageal strictures, and the sequela that result. Extraintestinal manifestations of gastroesophageal reflux disease (GERD) can appear similar to other pathologic diagnoses commonly found in EA patients, such as congenital stricture, eosinophilic esophagitis, esophageal dysmotility, tracheomalacia, recurrent fistula, aspiration, etc. Therefore, it is important to have a standardized way to monitor for these issues. pH impedance allows for detection of nonacid reflux and the height of reflux, which are important in correlating symptoms with reflux episodes. A multidisciplinary approach is beneficial in evaluating and monitoring EA patients in the long term.},\n\tlanguage = {eng},\n\tnumber = {12},\n\tjournal = {Current Gastroenterology Reports},\n\tauthor = {Mousa, Hayat and Krishnan, Usha and Hassan, Maheen and Dall'Oglio, Luigi and Rosen, Rachel and Gottrand, Frédéric and Faure, Christophe},\n\tmonth = nov,\n\tyear = {2017},\n\tpmid = {29177550},\n\tpmcid = {PMC6450800},\n\tkeywords = {Anastamotic strictures, Antacids, Complications, Eosinophilic Esophagitis, Eosinophilic esophagitis, Esophageal Atresia, Esophageal Stenosis, Esophageal atresia, Esophageal pH Monitoring, Gastroesophageal Reflux, Gastroesophageal reflux disease, Humans, Long-Term Care, Long-term follow-up, Multichannel intraluminal impedance, Review, Tracheoesophageal Fistula, Tracheoesophageal fistula},\n\tpages = {65},\n}\n\n\n\n

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\n \n 2016\n \n \n (5)\n \n \n

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\n \n\n \n \n \n \n \n \n Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia.\n \n \n \n \n\n\n \n Schneider, A.; Gottrand, F.; Bellaiche, M.; Becmeur, F.; Lachaux, A.; Bridoux-Henno, L.; Michel, J.; Faure, C.; Philippe, P.; Vandenplas, Y.; Dupont, C.; Breton, A.; Gaudin, J.; Lamireau, T.; Muyshont, L.; Podevin, G.; Viola, S.; Bertrand, V.; Caldari, D.; Colinet, S.; Wanty, C.; Sauleau, E.; Leteurtre, E.; and Michaud, L.\n\n\n \n\n\n\n Annals of Surgery, 264(6): 1004–1008. December 2016.\n \n\n\n\n
\n\n\n\n \n \n $\"Prevalence$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{schneider_prevalence_2016,\n\ttitle = {Prevalence of {Barrett} {Esophagus} in {Adolescents} and {Young} {Adults} {With} {Esophageal} {Atresia}},\n\tvolume = {264},\n\tissn = {1528-1140},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/26720426/},\n\tdoi = {10.1097/SLA.0000000000001540},\n\tabstract = {OBJECTIVE: To study the prevalence of Barrett esophagus (BE) (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia (EA).\nSUMMARY OF BACKGROUND DATA: EA patients are at high risk of BE.\nMETHODS: This multicenter prospective study included EA patients aged 15 to 19 years. All eligible patients were proposed an upper endoscopy with multistaged esophageal biopsies under general anesthesia. Histological suspicion of metaplasia was confirmed centrally.\nRESULTS: One hundred twenty patients [mean age, 16.5 years (±1.4)] were included; 70\\% had been treated for gastroesophageal reflux disease (GERD) during infancy. At evaluation, 8\\% were undernourished, 41\\% had received antireflux surgery, and 41\\% presented with GERD symptoms, although only 28\\% were receiving medical treatment. Esophagitis was found at endoscopy in 34\\% and confirmed at histology in 67\\%. BE was suspected after endoscopy in 37\\% and was confirmed by histology for 43\\% of patients (50 gastric and 1 intestinal metaplasia). No endoscopic or histological anomalies were found at the anastomosis site. BE was not significantly related to clinical symptoms. In multivariate analysis, BE was associated with EA without fistula (P = 0.03), previous multiple antireflux surgery (P = 0.04), esophageal dilation (P = 0.04), suspicion of BE at endoscopy (P {\\textless} 0.001), and histological esophagitis (P = 0.02).\nCONCLUSIONS: Patients with EA are at high risk of persistent GERD and BE. The development of BE is related to GERD history. Long-term systematic follow-up of the esophageal mucosa including multistaged biopsies is required, even in asymptomatic patients. (NCT02495051).},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Annals of Surgery},\n\tauthor = {Schneider, Anne and Gottrand, Frédéric and Bellaiche, Marc and Becmeur, François and Lachaux, Alain and Bridoux-Henno, Laure and Michel, Jean-Luc and Faure, Christophe and Philippe, Paul and Vandenplas, Yvan and Dupont, Claire and Breton, Anne and Gaudin, Jean and Lamireau, Thierry and Muyshont, Laurence and Podevin, Guillaume and Viola, Sheila and Bertrand, Valérie and Caldari, Dominique and Colinet, Stéphanie and Wanty, Catherine and Sauleau, Erik and Leteurtre, Emmanuelle and Michaud, Laurent},\n\tmonth = dec,\n\tyear = {2016},\n\tpmid = {26720426},\n\tkeywords = {Adolescent, Barrett Esophagus, Biopsy, Esophageal Atresia, Esophagitis, Esophagoscopy, Female, France, Gastroesophageal Reflux, Humans, Male, Prevalence, Prospective Studies, Young Adult},\n\tpages = {1004--1008},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Motility, digestive and nutritional problems in Esophageal Atresia.\n \n \n \n \n\n\n \n Gottrand, M.; Michaud, L.; Sfeir, R.; and Gottrand, F.\n\n\n \n\n\n\n Paediatric Respiratory Reviews, 19: 28–33. June 2016.\n \n\n\n\n
\n\n\n\n \n \n $\"Motility,$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gottrand_motility_2016,\n\ttitle = {Motility, digestive and nutritional problems in {Esophageal} {Atresia}},\n\tvolume = {19},\n\tissn = {1526-0550},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/26752295/},\n\tdoi = {10.1016/j.prrv.2015.11.005},\n\tabstract = {Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is a rare congenital malformation. Digestive and nutritional problems remain frequent in children with EA both in early infancy and at long-term follow-up. These patients are at major risk of presenting with gastroesophageal reflux and its complications, such as anastomotic strictures. Esophageal dysmotility is constant, and can have important consequences on feeding and nutritional status. Patients with EA need a systematic follow-up with a multidisciplinary team.},\n\tlanguage = {eng},\n\tjournal = {Paediatric Respiratory Reviews},\n\tauthor = {Gottrand, Madeleine and Michaud, Laurent and Sfeir, Rony and Gottrand, Frédéric},\n\tmonth = jun,\n\tyear = {2016},\n\tpmid = {26752295},\n\tkeywords = {Anastomotic stricture, Children, Constriction, Pathologic, Deglutition Disorders, Diagnostic Imaging, Dysmotility, Dysphagia, Esophageal Atresia, Esophageal Motility Disorders, Esophageal pH Monitoring, Esophagitis, Esophagoscopy, Gastro-Esophageal Reflux, Gastroesophageal Reflux, Growth Disorders, Growth Retardation, Humans, Infant, Infant, Newborn, Nutrition, Tracheoesophageal Fistula},\n\tpages = {28--33},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Pediatric Achalasia in the Netherlands: Incidence, Clinical Course, and Quality of Life.\n \n \n \n\n\n \n Smits, M.; van Lennep, M.; Vrijlandt, R.; Benninga, M.; Oors, J.; Houwen, R.; Kokke, F.; van der Zee, D.; Escher, J.; van den Neucker, A.; de Meij, T.; Bodewes, F.; Schweizer, J.; Damen, G.; Busch, O.; and van Wijk, M.\n\n\n \n\n\n\n The Journal of Pediatrics, 169: 110–115.e3. February 2016.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{smits_pediatric_2016,\n\ttitle = {Pediatric {Achalasia} in the {Netherlands}: {Incidence}, {Clinical} {Course}, and {Quality} of {Life}},\n\tvolume = {169},\n\tissn = {1097-6833},\n\tshorttitle = {Pediatric {Achalasia} in the {Netherlands}},\n\tdoi = {10.1016/j.jpeds.2015.10.057},\n\tabstract = {OBJECTIVE: To assess incidence and clinical course of Dutch patients with achalasia diagnosed before 18 years of age as well as their current symptoms and quality of life (QoL).\nSTUDY DESIGN: Retrospective medical chart review and a cross-sectional study assessing current clinical status using the Eckardt score and reflux disease questionnaire. General QoL was measured using Kidscreen-52 for patients {\\textless}18 years of age or to 36-Item Short Form Health Survey for patients ≥18 years of age.\nRESULTS: Between 1990 and 2013, 87 children (mean age 11.4 ± 3.4 years, 60\\% male) diagnosed with achalasia in the Netherlands were included. Mean incidence was 0.1/100,000/y (range 0.03-0.21). Initial treatment was pneumodilation (PD) in 68 (79\\%) patients and Heller myotomy (HM) in 18 (21\\%) patients. Retreatment was required more often after initial PD compared with initial HM (88\\% vs 22\\%; P {\\textless} .0001). More complications of initial treatment occurred after HM compared with PD (55.6\\% vs 1.5\\%; P {\\textless} .0001). Three esophageal perforations were seen after HM (16.7\\%), 1 after PD (1.5\\%). Sixty-three of 87 (72\\%) patients were prospectively contacted. Median Eckardt score was 3 (IQR 2-5), with 32 patients (44.5\\%) having positive scores suggesting active disease. Reflux disease questionnaire scores were higher after initial HM vs PD (1.71 [0.96-2.90] vs 0.58 [0-1.56]; P = .005). The 36-Item Short Form Health Survey (n = 52) was lower compared with healthy population norms for 7/8 domains. Kidscreen-52 (n = 20) was similar to population norms.\nCONCLUSIONS: Pediatric achalasia is rare and relapse rates are high after initial treatment, especially after pneumodilation, but with more complications after HM. Symptoms often persist into adulthood, without any clinical follow-up. QoL in adulthood was decreased.},\n\tlanguage = {eng},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Smits, Marije and van Lennep, Marinde and Vrijlandt, Remy and Benninga, Marc and Oors, Jac and Houwen, Roderick and Kokke, Freddy and van der Zee, David and Escher, Johanne and van den Neucker, Anita and de Meij, Tim and Bodewes, Frank and Schweizer, Joachim and Damen, Gerard and Busch, Olivier and van Wijk, Michiel},\n\tmonth = feb,\n\tyear = {2016},\n\tpmid = {26616251},\n\tkeywords = {Adolescent, Child, Cross-Sectional Studies, Esophageal Achalasia, Female, Humans, Incidence, Male, Netherlands, Quality of Life, Retrospective Studies},\n\tpages = {110--115.e3},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n ESPGHAN-NASPGHAN Guidelines for the Evaluation and Treatment of Gastrointestinal and Nutritional Complications in Children With Esophageal Atresia-Tracheoesophageal Fistula.\n \n \n \n \n\n\n \n Krishnan, U.; Mousa, H.; Dall'Oglio, L.; Homaira, N.; Rosen, R.; Faure, C.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 63(5): 550–570. November 2016.\n \n\n\n\n
\n\n\n\n \n \n $\"ESPGHAN-NASPGHAN$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{krishnan_espghan-naspghan_2016,\n\ttitle = {{ESPGHAN}-{NASPGHAN} {Guidelines} for the {Evaluation} and {Treatment} of {Gastrointestinal} and {Nutritional} {Complications} in {Children} {With} {Esophageal} {Atresia}-{Tracheoesophageal} {Fistula}},\n\tvolume = {63},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/27579697/},\n\tdoi = {10.1097/MPG.0000000000001401},\n\tabstract = {BACKGROUND: Esophageal atresia (EA) is one of the most common congenital digestive anomalies. With improvements in surgical techniques and intensive care treatments, the focus of care of these patients has shifted from mortality to morbidity and quality-of-life issues. These children face gastrointestinal (GI) problems not only in early childhood but also through adolescence and adulthood. There is, however, currently a lack of a systematic approach to the care of these patients. The GI working group of International Network on Esophageal Atresia comprises members from ESPGHAN/NASPGHAN and was charged with the task of developing uniform evidence-based guidelines for the management of GI complications in children with EA.\nMETHODS: Thirty-six clinical questions addressing the diagnosis, treatment, and prognosis of the common GI complications in patients with EA were formulated. Questions on the diagnosis, and treatment of gastroesophageal reflux, management of "cyanotic spells," etiology, investigation and management of dysphagia, feeding difficulties, anastomotic strictures, congenital esophageal stenosis in EA patients were addressed. The importance of excluding eosinophilic esophagitis and associated GI anomalies in symptomatic patients with EA is discussed as is the quality of life of these patients and the importance of a systematic transition of care to adulthood. A systematic literature search was performed from inception to March 2014 using Embase, MEDLINE, the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Clinical Trials, and PsychInfo databases. The approach of the Grading of Recommendations Assessment, Development and Evaluation was applied to evaluate outcomes. During 2 consensus meetings, all recommendations were discussed and finalized. The group members voted on each recommendation, using the nominal voting technique. Expert opinion was used where no randomized controlled trials were available to support the recommendation.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Krishnan, Usha and Mousa, Hayat and Dall'Oglio, Luigi and Homaira, Nusrat and Rosen, Rachel and Faure, Christophe and Gottrand, Frédéric},\n\tmonth = nov,\n\tyear = {2016},\n\tpmid = {27579697},\n\tkeywords = {Adolescent, Child, Disease Management, Esophageal Atresia, Guidelines as Topic, Humans, Quality of Life, Tracheoesophageal Fistula},\n\tpages = {550--570},\n}\n\n\n\n

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\n BACKGROUND: Esophageal atresia (EA) is one of the most common congenital digestive anomalies. With improvements in surgical techniques and intensive care treatments, the focus of care of these patients has shifted from mortality to morbidity and quality-of-life issues. These children face gastrointestinal (GI) problems not only in early childhood but also through adolescence and adulthood. There is, however, currently a lack of a systematic approach to the care of these patients. The GI working group of International Network on Esophageal Atresia comprises members from ESPGHAN/NASPGHAN and was charged with the task of developing uniform evidence-based guidelines for the management of GI complications in children with EA. METHODS: Thirty-six clinical questions addressing the diagnosis, treatment, and prognosis of the common GI complications in patients with EA were formulated. Questions on the diagnosis, and treatment of gastroesophageal reflux, management of \"cyanotic spells,\" etiology, investigation and management of dysphagia, feeding difficulties, anastomotic strictures, congenital esophageal stenosis in EA patients were addressed. The importance of excluding eosinophilic esophagitis and associated GI anomalies in symptomatic patients with EA is discussed as is the quality of life of these patients and the importance of a systematic transition of care to adulthood. A systematic literature search was performed from inception to March 2014 using Embase, MEDLINE, the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Clinical Trials, and PsychInfo databases. The approach of the Grading of Recommendations Assessment, Development and Evaluation was applied to evaluate outcomes. During 2 consensus meetings, all recommendations were discussed and finalized. The group members voted on each recommendation, using the nominal voting technique. Expert opinion was used where no randomized controlled trials were available to support the recommendation.\n

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\n \n\n \n \n \n \n \n \n Esophageal tissue engineering: Current status and perspectives.\n \n \n \n \n\n\n \n Poghosyan, T.; Catry, J.; Luong-Nguyen, M.; Bruneval, P.; Domet, T.; Arakelian, L.; Sfeir, R.; Michaud, L.; Vanneaux, V.; Gottrand, F.; Larghero, J.; and Cattan, P.\n\n\n \n\n\n\n Journal of Visceral Surgery, 153(1): 21–29. February 2016.\n \n\n\n\n
\n\n\n\n \n \n $\"Esophageal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{poghosyan_esophageal_2016,\n\ttitle = {Esophageal tissue engineering: {Current} status and perspectives},\n\tvolume = {153},\n\tissn = {1878-7886},\n\tshorttitle = {Esophageal tissue engineering},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/26711880/},\n\tdoi = {10.1016/j.jviscsurg.2015.11.009},\n\tabstract = {Tissue engineering, which consists of the combination and in vivo implantation of elements required for tissue remodeling toward a specific organ phenotype, could be an alternative for classical techniques of esophageal replacement. The current hybrid approach entails creation of an esophageal substitute composed of an acellular matrix and autologous epithelial and muscle cells provides the most successful results. Current research is based on the use of mesenchymal stem cells, whose potential for differentiation and proangioogenic, immune-modulator and anti-inflammatory properties are important assets. In the near future, esophageal substitutes could be constructed from acellular "intelligent matrices" that contain the molecules necessary for tissue regeneration; this should allow circumvention of the implantation step and still obtain standardized in vivo biological responses. At present, tissue engineering applications to esophageal replacement are limited to enlargement plasties with absorbable, non-cellular matrices. Nevertheless, the application of existing clinical techniques for replacement of other organs by tissue engineering in combination with a multiplication of translational research protocols for esophageal replacement in large animals should soon pave the way for health agencies to authorize clinical trials.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Visceral Surgery},\n\tauthor = {Poghosyan, T. and Catry, J. and Luong-Nguyen, M. and Bruneval, P. and Domet, T. and Arakelian, L. and Sfeir, R. and Michaud, L. and Vanneaux, V. and Gottrand, F. and Larghero, J. and Cattan, P.},\n\tmonth = feb,\n\tyear = {2016},\n\tpmid = {26711880},\n\tkeywords = {Absorbable scaffold, Animals, Bioengineering, Bioreactors, Esophagus, Humans, Mesenchymal Stem Cells, Plastic Surgery Procedures, Tissue Engineering, Tissue Scaffolds, Tissue engineering},\n\tpages = {21--29},\n}\n\n\n\n

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\n \n 2015\n \n \n (8)\n \n \n

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\n \n\n \n \n \n \n \n \n The contribution of fetal MR imaging to the assessment of oesophageal atresia.\n \n \n \n \n\n\n \n Hochart, V.; Verpillat, P.; Langlois, C.; Garabedian, C.; Bigot, J.; Debarge, V. H.; Sfeir, R.; and Avni, F. E.\n\n\n \n\n\n\n European Radiology, 25(2): 306–314. February 2015.\n \n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{hochart_contribution_2015,\n\ttitle = {The contribution of fetal {MR} imaging to the assessment of oesophageal atresia},\n\tvolume = {25},\n\tissn = {1432-1084},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/25304819/},\n\tdoi = {10.1007/s00330-014-3444-y},\n\tabstract = {OBJECTIVE: Present challenges are to improve the diagnosis rate of oesophageal atresia (OA) and evaluate as completely as possible a fetus affected by OA, specifically the type of OA and the length of the gap. Our aim was to evaluate the accuracy of fetal MR imaging (fMRI) for diagnosis of OA.\nMETHODS: We reviewed fMRI performed because of sonographic suspicion of an OA. The signs reviewed included stomach size, "pouch sign", bowing of the trachea and visualization of the lower oesophageal lumen. The fetuses were assigned by consensus as having or not having EA, as well as having a tracheaoesophageal fistula (TOF). All findings were correlated with postnatal data. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were calculated.\nRESULTS: Se, Sp, PPV and NPV of the technique were respectively 91\\%, 100\\%, 100\\% and 88\\%. The presence of the pouch sign yielded corresponding values of 82\\%, 100\\%, 100\\% and 78\\%. Mid-tracheal bowing was correlated positively with EA. The type of atresia was correctly evaluated in 90\\% of patients.\nCONCLUSION: fMRI is useful for the diagnosis of EA through the visualization of the oesophageal pouch or through associated signs such as tracheal bowing. Visualization of the lower oesophageal lumen seems to be a good sign of TEF.\nKEY POINTS: • Challenges are to improve the prenatal diagnosis of EA and associated malformations. • fMRI is able to diagnose EA through demonstration of the pouch sign. • Tracheal bowing is a promising indirect sign of EA. • Tracheoesophageal fistula can also be suspected thanks to fMRI. • Obstetrical US, fMRI and fetal CT are complementary for assessing associated malformations.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {European Radiology},\n\tauthor = {Hochart, V. and Verpillat, P. and Langlois, C. and Garabedian, C. and Bigot, J. and Debarge, V. Houfflin and Sfeir, R. and Avni, F. E.},\n\tmonth = feb,\n\tyear = {2015},\n\tpmid = {25304819},\n\tkeywords = {Adult, Esophageal Atresia, Female, Fetal Diseases, Gestational Age, Humans, Magnetic Resonance Imaging, Pregnancy, Prenatal Diagnosis, Retrospective Studies, Sensitivity and Specificity, Stomach, Tracheoesophageal Fistula},\n\tpages = {306--314},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Safety of the One-Step Percutaneous Endoscopic Gastrostomy Button in Children.\n \n \n \n \n\n\n \n Jacob, A.; Delesalle, D.; Coopman, S.; Bridenne, M.; Guimber, D.; Turck, D.; Gottrand, F.; and Michaud, L.\n\n\n \n\n\n\n The Journal of Pediatrics, 166(6): 1526–1528. June 2015.\n \n\n\n\n
\n\n\n\n \n \n $\"Safety$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{jacob_safety_2015,\n\ttitle = {Safety of the {One}-{Step} {Percutaneous} {Endoscopic} {Gastrostomy} {Button} in {Children}},\n\tvolume = {166},\n\tissn = {1097-6833},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/25868429/},\n\tdoi = {10.1016/j.jpeds.2015.03.008},\n\tabstract = {Pediatric experience using the single-stage percutaneous endoscopic gastrostomy button has been reported anecdotally. This 3-year prospective monocentric study, including 183 children, demonstrates that this technique is safe, with a low rate of infection, and compares favorably with the pull technique of percutaneous endoscopic gastrostomy while necessitating only one general anesthesia.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {The Journal of Pediatrics},\n\tauthor = {Jacob, Anne and Delesalle, Dorothée and Coopman, Stéphanie and Bridenne, Marie and Guimber, Dominique and Turck, Dominique and Gottrand, Frédéric and Michaud, Laurent},\n\tmonth = jun,\n\tyear = {2015},\n\tpmid = {25868429},\n\tkeywords = {Adolescent, Child, Child, Preschool, Costs and Cost Analysis, Feasibility Studies, Female, Gastroscopy, Gastrostomy, Humans, Infant, Male, Postoperative Complications, Prospective Studies},\n\tpages = {1526--1528},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n ESPGHAN position paper on management of percutaneous endoscopic gastrostomy in children and adolescents.\n \n \n \n \n\n\n \n Heuschkel, R. B.; Gottrand, F.; Devarajan, K.; Poole, H.; Callan, J.; Dias, J. A.; Karkelis, S.; Papadopoulou, A.; Husby, S.; Ruemmele, F.; Schäppi, M. G.; Wilschanski, M.; Lionetti, P.; Orel, R.; Tovar, J.; Thapar, N.; Vandenplas, Y.; European Society for Pediatric Gastroenterology, Hepatology,; and Nutrition\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 60(1): 131–141. January 2015.\n \n\n\n\n
\n\n\n\n \n \n $\"ESPGHAN$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{heuschkel_espghan_2015,\n\ttitle = {{ESPGHAN} position paper on management of percutaneous endoscopic gastrostomy in children and adolescents},\n\tvolume = {60},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/25023584/},\n\tdoi = {10.1097/MPG.0000000000000501},\n\tabstract = {OBJECTIVES: This European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) position statement provides a comprehensive guide for health care providers to manage percutaneous endoscopic gastrostomy tubes in a safe, effective, and appropriate way.\nMETHODS: Relevant literature from searches of PubMed, CINAHL, and recent guidelines was reviewed. In the absence of evidence, recommendations reflect the expert opinion of the authors. Final consensus was obtained by multiple e-mail exchange and during 3 face-to-face meetings of the gastroenterology committee of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.\nRESULTS: Endoscopically placed gastrostomy devices are essential in the management of children with feeding and nutritional problems. The article focuses on practical issues such as indications and contraindications.\nCONCLUSIONS: The decision to place an endoscopic gastrostomy has to be made by an appropriate multidisciplinary team, which then provides active follow-up and care for the child and the device.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Heuschkel, R. B. and Gottrand, F. and Devarajan, K. and Poole, H. and Callan, J. and Dias, J. A. and Karkelis, S. and Papadopoulou, A. and Husby, S. and Ruemmele, F. and Schäppi, M. G. and Wilschanski, M. and Lionetti, P. and Orel, R. and Tovar, J. and Thapar, N. and Vandenplas, Y. and {European Society for Pediatric Gastroenterology, Hepatology, and Nutrition}},\n\tmonth = jan,\n\tyear = {2015},\n\tpmid = {25023584},\n\tkeywords = {Adolescent, Adolescent Nutritional Physiological Phenomena, Child, Child Nutritional Physiological Phenomena, Enteral Nutrition, Europe, Evidence-Based Medicine, Gastrostomy, Humans, Infant, Infant Nutritional Physiological Phenomena, Interdisciplinary Communication, Postoperative Complications, Societies, Scientific},\n\tpages = {131--141},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?.\n \n \n \n \n\n\n \n Garabedian, C.; Sfeir, R.; Langlois, C.; Bonnard, A.; Khen-Dunlop, N.; Gelas, T.; Michaud, L.; Auber, F.; Gottrand, F.; Houfflin-Debarge, V.; and French Network on Esophageal Atresia\n\n\n \n\n\n\n American Journal of Obstetrics and Gynecology, 212(3): 340.e1–7. March 2015.\n \n\n\n\n
\n\n\n\n \n \n $\"Does$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{garabedian_does_2015,\n\ttitle = {Does prenatal diagnosis modify neonatal treatment and early outcome of children with esophageal atresia?},\n\tvolume = {212},\n\tissn = {1097-6868},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/25265404/},\n\tdoi = {10.1016/j.ajog.2014.09.030},\n\tabstract = {OBJECTIVE: Our study aimed at (1) evaluating neonatal treatment and outcome of neonates with either a prenatal or a postnatal diagnosis of esophageal atresia (EA) and (2) analyzing the impact of prenatal diagnosis on outcome based on the type of EA.\nSTUDY DESIGN: We conducted a population-based study using data from the French National Register for infants with EA born from 2008-2010. We compared prenatal, maternal, and neonatal characteristics among children with prenatal vs postnatal diagnosis and EA types I and III. We defined a composite variable of morbidity (anastomotic esophageal leaks, recurrent fistula, stenosis) and death at 1 year.\nRESULTS: Four hundred sixty-nine live births with EA were recorded with a prenatal diagnosis rate of 24.3\\%; 82.2\\% of EA type I were diagnosed prenatally compared with 17.9\\% of EA type III (P {\\textless} .001). Transfer after birth was lower in case of prenatal diagnosis (25.6\\% vs 82.5\\%; P {\\textless} .001). The delay between birth and first intervention did not differ significantly among groups. The defect size was longer among the prenatal diagnosis group (2.61 vs 1.48 cm; P {\\textless} .001). The composite variables were higher in prenatal diagnosis subset (44\\% vs 27.6\\%; P = .003) and in EA type I than in type III (58.1\\% vs 28.3\\%; P {\\textless} .001).\nCONCLUSION: Despite the excellent survival rate of EA, cases with antenatal detection have a higher morbidity rate related to the EA type (type I and/or long gap). Even though it does not modify neonatal treatment and the 1-year outcome, prenatal diagnosis allows antenatal parental counselling and avoids postnatal transfers.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {American Journal of Obstetrics and Gynecology},\n\tauthor = {Garabedian, Charles and Sfeir, Rony and Langlois, Carole and Bonnard, Arnaud and Khen-Dunlop, Naziha and Gelas, Thomas and Michaud, Laurent and Auber, Fréderic and Gottrand, Fréderic and Houfflin-Debarge, Véronique and {French Network on Esophageal Atresia}},\n\tmonth = mar,\n\tyear = {2015},\n\tpmid = {25265404},\n\tkeywords = {Combined Modality Therapy, Esophageal Atresia, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Pregnancy, Prenatal Diagnosis, Registries, Survival Analysis, Treatment Outcome, associated anomaly, esophageal atresia, outcome, postnatal diagnosis, prenatal diagnosis},\n\tpages = {340.e1--7},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Congenital esophageal stenosis associated with esophageal atresia.\n \n \n \n \n\n\n \n McCann, F.; Michaud, L.; Aspirot, A.; Levesque, D.; Gottrand, F.; and Faure, C.\n\n\n \n\n\n\n Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus, 28(3): 211–215. April 2015.\n \n\n\n\n
\n\n\n\n \n \n $\"Congenital$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{mccann_congenital_2015,\n\ttitle = {Congenital esophageal stenosis associated with esophageal atresia},\n\tvolume = {28},\n\tissn = {1442-2050},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/24446921/},\n\tdoi = {10.1111/dote.12176},\n\tabstract = {Congenital esophageal stenosis (CES) is a rare clinical condition but is frequently associated with esophageal atresia (EA). The aim of this study is to report the diagnosis, management, and outcome of CES associated with EA. Medical charts of CES-EA patients from Lille University Hospital, Sainte-Justine Hospital, and Montreal Children's Hospital were retrospectively reviewed. Seventeen patients (13 boys) were included. The incidence of CES in patients with EA was 3.6\\%. Fifteen patients had a type C EA, one had a type A EA, and one had an isolated tracheoesophageal fistula. Seven patients had associated additional malformations. The mean age at diagnosis was 11.6 months. All but two patients had non-specific symptoms such as regurgitations or dysphagia. One CES was diagnosed at the time of surgical repair of EA. In 12 patients, CES was suspected based on abnormal barium swallow. In the remaining four, the diagnostic was confirmed by esophagoscopy. Eleven patients were treated by dilation only (1-3 dilations/patient). Six patients underwent surgery (resection and anastomosis) because of failure of attempted dilations (1-7 dilations/patient). Esophageal perforation was encountered in three patients (18\\%). Three patients had histologically proven tracheobronchial remnants. CES associated with EA is frequent. A high index of suspicion for CES must remain in the presence of EA. Dilatation may be effective to treat some of them, but perforation is frequent. Surgery may be required, especially in CES secondary to ectopic tracheobronchial remnants.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus},\n\tauthor = {McCann, F. and Michaud, L. and Aspirot, A. and Levesque, D. and Gottrand, F. and Faure, C.},\n\tmonth = apr,\n\tyear = {2015},\n\tpmid = {24446921},\n\tkeywords = {Abnormalities, Multiple, Anastomosis, Surgical, Child, Preschool, Deglutition Disorders, Dilatation, Esophageal Atresia, Esophageal Perforation, Esophageal Stenosis, Esophagoscopy, Female, Gastroesophageal Reflux, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Tracheoesophageal Fistula, children, congenital stenosis, esophageal atresia},\n\tpages = {211--215},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Circumferential esophageal replacement using a tube-shaped tissue-engineered substitute: An experimental study in minipigs.\n \n \n \n \n\n\n \n Poghosyan, T.; Sfeir, R.; Michaud, L.; Bruneval, P.; Domet, T.; Vanneaux, V.; Luong-Nguyen, M.; Gaujoux, S.; Gottrand, F.; Larghero, J.; and Cattan, P.\n\n\n \n\n\n\n Surgery, 158(1): 266–277. July 2015.\n \n\n\n\n
\n\n\n\n \n \n $\"Circumferential$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{poghosyan_circumferential_2015,\n\ttitle = {Circumferential esophageal replacement using a tube-shaped tissue-engineered substitute: {An} experimental study in minipigs},\n\tvolume = {158},\n\tissn = {1532-7361},\n\tshorttitle = {Circumferential esophageal replacement using a tube-shaped tissue-engineered substitute},\n\turl = {http://hdl.handle.net/20.500.12210/4703},\n\tdoi = {10.1016/j.surg.2015.01.020},\n\tabstract = {BACKGROUND: Esophageal replacement by the colon or the stomach for malignant and nonmalignant esophageal diseases exposes to significant morbidity and mortality. In this setting, tissue engineering seems to be a seductive alternative.\nMETHODS: In a porcine model, we performed a 5-cm-long circumferential replacement of the cervical esophagus by a tubulized acellular matrix (small intestinal submucosa) cellularized with autologous skeletal myoblasts and covered by a human amniotic membrane seeded with autologous oral epithelial cells. The substitute was grown for 2 weeks in the great omentum before esophageal replacement. Eighteen minipigs (divided into 3 groups: group A [substitute with esophageal endoprothesis; n = 6], group B [substitute alone; n = 6], and group C [endoprothesis alone; n = 6]) were included. The esophageal endoprothesis was removed at 6 months. Animals were killed sequentially over a 12 month-period. Clinical, endoscopic, radiologic and histologic outcomes were analyzed.\nRESULTS: All animals except 1 of in groups B and C died during the first 2 months owing to refractory esophageal stenosis or endoprothesis extrusion. Nutritional autonomy without endoprothesis was observed in all animals of group A with a follow-up of {\\textgreater}6 months (n = 3). A phenotype similar to that of native esophagus, consisting of a mature epithelium, submucosal glands, and a circular muscular layer, was observed after 9 months.\nCONCLUSION: In this model, the circumferential replacement of the cervical esophagus by a tube-shaped tissue-engineered substitute under the temporary cover of an esophageal endoprothesis allowed nutritional autonomy and tissue remodeling toward an esophageal phenotype.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Surgery},\n\tauthor = {Poghosyan, Tigran and Sfeir, Rony and Michaud, Laurent and Bruneval, Patrick and Domet, Thomas and Vanneaux, Valerie and Luong-Nguyen, Minh and Gaujoux, Sebastien and Gottrand, Frederic and Larghero, Jerome and Cattan, Pierre},\n\tmonth = jul,\n\tyear = {2015},\n\tpmid = {25796416},\n\tkeywords = {Animals, Artificial Organs, Esophagus, Intestine, Small, Male, Models, Animal, Swine, Swine, Miniature, Tissue Engineering, Tissue Scaffolds},\n\tpages = {266--277},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n National Esophageal Atresia Register.\n \n \n \n \n\n\n \n Sfeir, R.; Michaud, L.; Sharma, D.; Richard, F.; and Gottrand, F.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 25(6): 497–499. December 2015.\n \n\n\n\n
\n\n\n\n \n \n $\"National$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{sfeir_national_2015,\n\ttitle = {National {Esophageal} {Atresia} {Register}},\n\tvolume = {25},\n\tissn = {1439-359X},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/26642387/},\n\tdoi = {10.1055/s-0035-1569466},\n\tabstract = {National Esophageal Atresia was created in 2008 by the National Reference Center for Esophageal Congenital Abnormalities created in 2006. Primary goal was estimation of live birth prevalence in France. A national network of surgeons and pediatricians was initiated and entire teams dealing with esophageal atresia accepted to participate in an exhaustive national register. A questionnaire was validated by a national committee and data were centralized in our center. Scientific exploitation showed that such database is useful for health authorities as for medical professionals. Live birth prevalence in France is at 1.9/10,000 births. Prenatal diagnosis is more common but its effect on prevalence is not yet fully understood. Associated congenital abnormalities are frequent and major malformations with termination of pregnancy can influence prevalence.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Sfeir, Rony and Michaud, Laurent and Sharma, Duyti and Richard, Florence and Gottrand, Frédéric},\n\tmonth = dec,\n\tyear = {2015},\n\tpmid = {26642387},\n\tkeywords = {Esophageal Atresia, Female, France, Humans, Pregnancy, Prenatal Diagnosis, Prevalence, Registries},\n\tpages = {497--499},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Amniotic fluid biochemistry in isolated polyhydramnios: a series of 464 cases.\n \n \n \n \n\n\n \n Allaf, B.; Dreux, S.; Schmitz, T.; Czerkiewicz, I.; Le Vaillant, C.; Benachi, A.; Houfflin-Debarge, V.; Maréchaud, M.; Oury, J.; and Muller, F.\n\n\n \n\n\n\n Prenatal Diagnosis, 35(13): 1331–1335. December 2015.\n \n\n\n\n
\n\n\n\n \n \n $\"Amniotic$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{allaf_amniotic_2015,\n\ttitle = {Amniotic fluid biochemistry in isolated polyhydramnios: a series of 464 cases},\n\tvolume = {35},\n\tissn = {1097-0223},\n\tshorttitle = {Amniotic fluid biochemistry in isolated polyhydramnios},\n\turl = {http://hdl.handle.net/20.500.12210/116422},\n\tdoi = {10.1002/pd.4700},\n\tabstract = {OBJECTIVE: To report amniotic fluid biochemistry in a large series of 464 cases of isolated polyhydramnios in order to analyze both the outcome and the benefit of amniotic fluid biochemistry.\nMETHODS: This retrospective cohort (2008-2012) included polyhydramnios cases for which amniotic fluid samples were sent to our laboratory for biochemical analysis (total protein, alpha-fetoprotein and gamma-glutamyl transpeptidase) so as to investigate the etiology. A Bartter index and an esophageal atresia index were defined. Final diagnoses were compared between groups to determine the association between these indices and the frequency and type of adverse outcomes.\nRESULTS: Among 464 cases of polyhydramnios considered isolated at ultrasound examination, severe fetal diseases were diagnosed in 136 (29.3\\%): 46 (9.9\\%) chromosomal anomalies, 28 (6\\%) Bartter syndrome, 23 (4.95\\%) other genetic syndromes, 22 (4.75\\%) swallowing disorders and 17 (3.7\\%) uro-nephrological disorders. Amniotic fluid biochemistry identified esophageal atresia with 66.6\\% (10/15) sensitivity and 100\\% specificity and Bartter syndrome with 85.7\\% (24/28) sensitivity and 84.2\\% specificity.\nCONCLUSION: Isolated polyhydramnios is associated with a high risk of severe fetal diseases. Molecular cytogenetics and amniotic fluid biochemistry are helpful tools.},\n\tlanguage = {eng},\n\tnumber = {13},\n\tjournal = {Prenatal Diagnosis},\n\tauthor = {Allaf, Bichr and Dreux, Sophie and Schmitz, Thomas and Czerkiewicz, Isabelle and Le Vaillant, Claudine and Benachi, Alexandra and Houfflin-Debarge, Véronique and Maréchaud, Martine and Oury, Jean-François and Muller, Françoise},\n\tmonth = dec,\n\tyear = {2015},\n\tpmid = {26426702},\n\tkeywords = {Amniotic Fluid, Chromosome Disorders, Female, Humans, Polyhydramnios, Pregnancy},\n\tpages = {1331--1335},\n}\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Results from the French National Esophageal Atresia register: one-year outcome.\n \n \n \n \n\n\n \n Schneider, A.; Blanc, S.; Bonnard, A.; Khen-Dunlop, N.; Auber, F.; Breton, A.; Podevin, G.; Sfeir, R.; Fouquet, V.; Jacquier, C.; Lemelle, J.; Lavrand, F.; Becmeur, F.; Petit, T.; Poli-Merol, M.; Elbaz, F.; Merrot, T.; Michel, J.; Hossein, A.; Lopez, M.; Habonimana, E.; Pelatan, C.; De Lagausie, P.; Buisson, P.; de Vries, P.; Gaudin, J.; Lardy, H.; Borderon, C.; Borgnon, J.; Jaby, O.; Weil, D.; Aubert, D.; Geiss, S.; Breaud, J.; Echaieb, A.; Languepin, J.; Laplace, C.; Pouzac, M.; Lefebvre, F.; Gottrand, F.; and Michaud, L.\n\n\n \n\n\n\n Orphanet Journal of Rare Diseases, 9: 206. December 2014.\n \n\n\n\n
\n\n\n\n \n \n $\"Results$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{schneider_results_2014,\n\ttitle = {Results from the {French} {National} {Esophageal} {Atresia} register: one-year outcome},\n\tvolume = {9},\n\tissn = {1750-1172},\n\tshorttitle = {Results from the {French} {National} {Esophageal} {Atresia} register},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/25496976/},\n\tdoi = {10.1186/s13023-014-0206-5},\n\tabstract = {BACKGROUND: The aim of the present national prospective population-based study was to assess the early morbidity of esophageal atresia (EA).\nMETHODS: All 38 multidisciplinary French centers that care for patients with EA returned a specific questionnaire about the 1-year outcome for each patient. This information was centralized, checked, and entered into a database.\nRESULTS: From the total population of 307 EA patients born in 2008 and 2009, data about the 1-year outcome were obtained from 301 (98\\%) patients, of whom 4\\% were lost to follow-up and 5\\% died. Medical complications occurred in 34\\% of the patients: anastomotic leaks (8\\%), recurrent tracheoesophageal fistula (4\\%), and anastomotic stenosis (22\\%); all of the latter group needed dilation (median, 2 dilations/patient). A new hospitalization was required for 59\\% of patients (2.5 hospitalizations/patient) for digestive (52\\%) or respiratory (48\\%) reasons. Twelve percent of patients required antireflux surgery at a median age of 164 days (range, 33-398 days), and 1\\% underwent an aortopexy for severe tracheomalacia. The weight/age Z-score was -0.8 (range, -5.5 to 3.7 months) at 12 months. Fifteen percent of patients were undernourished at 12 months of age, whereas 37\\% presented with respiratory symptoms and 15\\% had dysphagia at the last follow-up. Significant independent factors associated with medical complications were anastomotic esophageal tension (p = .0009) and presence of a gastrostomy (p = .0002); exclusive oral feeding at discharge was associated with a decreased risk of complications (p = .007).\nCONCLUSIONS: Digestive and respiratory morbidities remain frequent during the first year of life and are associated with difficult anastomosis and lack of full oral feeding.},\n\tlanguage = {eng},\n\tjournal = {Orphanet Journal of Rare Diseases},\n\tauthor = {Schneider, Anne and Blanc, Sébastien and Bonnard, Arnaud and Khen-Dunlop, Naziha and Auber, Frédéric and Breton, Anne and Podevin, Guillaume and Sfeir, Rony and Fouquet, Virginie and Jacquier, Catherine and Lemelle, Jean-Louis and Lavrand, Frédéric and Becmeur, François and Petit, Thierry and Poli-Merol, Marie-Laurence and Elbaz, Frédéric and Merrot, Thierry and Michel, Jean-Luc and Hossein, Allal and Lopez, Manuel and Habonimana, Edouard and Pelatan, Cécile and De Lagausie, Pascal and Buisson, Philippe and de Vries, Philine and Gaudin, Jean and Lardy, Hubert and Borderon, Corine and Borgnon, Joséphine and Jaby, Olivier and Weil, Dominique and Aubert, Didier and Geiss, Stephan and Breaud, Jean and Echaieb, Anis and Languepin, Jane and Laplace, Christophe and Pouzac, Myriam and Lefebvre, François and Gottrand, Frédéric and Michaud, Laurent},\n\tmonth = dec,\n\tyear = {2014},\n\tpmid = {25496976},\n\tpmcid = {PMC4265341},\n\tkeywords = {Esophageal Atresia, Female, Follow-Up Studies, France, Hospitalization, Humans, Infant, Infant, Newborn, Male, Population Surveillance, Registries, Time Factors, Treatment Outcome},\n\tpages = {206},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n [Esophageal atresia: prevalence, prenatal diagnosis and prognosis].\n \n \n \n\n\n \n Garabedian, C.; Vaast, P.; Bigot, J.; Sfeir, R.; Michaud, L.; Gottrand, F.; Verpillat, P.; Coulon, C.; Subtil, D.; and Houfflin Debarge, V.\n\n\n \n\n\n\n Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction, 43(6): 424–430. June 2014.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{garabedian_esophageal_2014,\n\ttitle = {[{Esophageal} atresia: prevalence, prenatal diagnosis and prognosis]},\n\tvolume = {43},\n\tissn = {1773-0430},\n\tshorttitle = {[{Esophageal} atresia},\n\tdoi = {10.1016/j.jgyn.2013.11.014},\n\tabstract = {Esophageal atresia (EA) is a rare congenital malformation (1 in 2,500 to 3,500 births). Prenatal diagnosis (PN) is particularly interesting allowing search for associated malformations related to worse prognosis forms (reference ultrasound, MRI and amniocentesis) and planning the birth in an adapted medico-surgical center. Diagnosis of EA is usually suspected because of indirect and non-specific signs: association of polyhydramnios and absent or small stomach bubble. The visualization in ultrasound or MRI of cervical or thoracic fluid image corresponding to the expansion of the bottom of upper esophageal ("pouch sign") increases the specificity of diagnosis. However, prenatal diagnosis remains difficult and less than 50 \\% of EA are diagnosed prenatally. Biochemical analysis could improve these results. If EA is confirmed at birth, surgical management consists in a primary end-to-end anastomosis in first days of life, or in two-steps surgery if the defect is too large. Although current prognosis of EA is good, frequency of surgical complications and esophageal lesions secondary to gastroesophageal reflux justify a systematic and multidisciplinary extended follow-up.},\n\tlanguage = {fre},\n\tnumber = {6},\n\tjournal = {Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction},\n\tauthor = {Garabedian, C. and Vaast, P. and Bigot, J. and Sfeir, R. and Michaud, L. and Gottrand, F. and Verpillat, P. and Coulon, C. and Subtil, D. and Houfflin Debarge, V.},\n\tmonth = jun,\n\tyear = {2014},\n\tpmid = {24440126},\n\tkeywords = {Analyse biochimique amniotique, Atrésie de l’œsophage, Biochemical amniotic fluid, Diagnostic anténatal, Esophageal Atresia, Esophageal atresia, Female, Fetal Diseases, Fetal ultrasound, Humans, IRM, MRI, Pregnancy, Prenatal Diagnosis, Prenatal diagnosis, Prognosis, Échographie fœtale},\n\tpages = {424--430},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Does a combination of ultrasound, MRI, and biochemical amniotic fluid analysis improve prenatal diagnosis of esophageal atresia?.\n \n \n \n \n\n\n \n Garabedian, C.; Verpillat, P.; Czerkiewicz, I.; Langlois, C.; Muller, F.; Avni, F.; Bigot, J.; Sfeir, R.; Vaast, P.; Coulon, C.; Subtil, D.; and Houfflin-Debarge, V.\n\n\n \n\n\n\n Prenatal Diagnosis, 34(9): 839–842. September 2014.\n \n\n\n\n
\n\n\n\n \n \n $\"Does$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{garabedian_does_2014,\n\ttitle = {Does a combination of ultrasound, {MRI}, and biochemical amniotic fluid analysis improve prenatal diagnosis of esophageal atresia?},\n\tvolume = {34},\n\tissn = {1097-0223},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/24706336/},\n\tdoi = {10.1002/pd.4376},\n\tabstract = {OBJECTIVE: Prenatal diagnosis of esophageal atresia (EA) remains a challenge. Our objective was to evaluate the combination of sonography, magnetic resonance imaging (MRI), and amniotic fluid biochemical markers in prenatal diagnosis of EA.\nSTUDY DESIGN: A retrospective study of all cases with prenatal suspicion of EA from January 2008 to May 2013 in our regional reference center was carried out. Patients were included if all the three tests were performed. For each test, sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) were evaluated. Each test was compared using Fisher's exact test.\nRESULTS: Fifteen patients were referred at a median gestational age of 28(+5)  weeks (24-36) for suspicion of EA on the basis of small or non-visualized fetal stomach bubble and/or polyhydramnios. Se, Sp, PPV, and NPV for sonographic pouch sign/MRI/biochemical amniotic fluid were respectively 40/100/100/45.5\\%, 80/100/100/71.4\\%, and 90/60/81.8/75\\%. MRI was the best predictive test (p = 0.007).\nCONCLUSION: In case of ultrasound prenatal suspicion of EA (with or without visualization of the pouch sign), an MRI at 30-32 weeks using fast imaging employing steady-state acquisition should be proposed. Biochemical amniotic fluid may be helpful and should be evaluated in a larger study.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Prenatal Diagnosis},\n\tauthor = {Garabedian, C. and Verpillat, P. and Czerkiewicz, I. and Langlois, C. and Muller, F. and Avni, F. and Bigot, J. and Sfeir, R. and Vaast, P. and Coulon, C. and Subtil, D. and Houfflin-Debarge, V.},\n\tmonth = sep,\n\tyear = {2014},\n\tpmid = {24706336},\n\tkeywords = {Amniocentesis, Amniotic Fluid, Biomarkers, Esophageal Atresia, Female, Humans, Magnetic Resonance Imaging, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Retrospective Studies, Sensitivity and Specificity, Ultrasonography, Prenatal},\n\tpages = {839--842},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Short-term neurodevelopmental outcome of babies operated on for low-risk esophageal atresia: a pilot study.\n \n \n \n\n\n \n Aite, L.; Bevilacqua, F.; Zaccara, A.; Ravà, L.; Valfrè, L.; Conforti, A.; Braguglia, A.; and Bagolan, P.\n\n\n \n\n\n\n Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus, 27(4): 330–334. 2014.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{aite_short-term_2014,\n\ttitle = {Short-term neurodevelopmental outcome of babies operated on for low-risk esophageal atresia: a pilot study},\n\tvolume = {27},\n\tissn = {1442-2050},\n\tshorttitle = {Short-term neurodevelopmental outcome of babies operated on for low-risk esophageal atresia},\n\tdoi = {10.1111/dote.12114},\n\tabstract = {Data on the neurodevelopmental outcome of esophageal atresia (EA) survivors are scarce, controversial, and based on small samples. This is an observational prospective longitudinal study on a selected cohort of low-risk EA survivors. We considered a low-risk EA survivor a patient with the following characteristics: gestational age {\\textgreater}32 weeks, no long gap, no genetic or chromosomic anomaly associated with neurodevelopmental delay, and no further major surgical congenital anomalies. Infants were evaluated with scales derived from the Bayley Scales of Infant and Toddler Development - 3rd Edition at 6 and 12 months, with a score of 100 considered normal for each scale. Analysis of variance was used to assess differences of cognitive and motor development. Linear regression was used to assess the impact of the following clinical and sociodemographic variables: gender, birthweight, gestational age, length of hospital stay, number of surgeries and number of esophageal dilatations during first hospitalization, days of mechanical ventilation, weight at follow up, number of surgeries and esophageal dilatations at follow up, parental age, educational level, and socioeconomic status. Thirty children form the object of the study. The mean (standard deviation [SD]) cognitive scale's score was 93.7 (7.5) and 98.2 (9.6) at 6 and 12 months, respectively (P {\\textless} 0.05). The mean (SD) motor scale's score was 97.6 (9.3) and 98.0 (12.1) at 6 and 12 months, respectively (P = n.s.). Children with a body weight {\\textless}5° percentile at 12 months showed a mean (SD) cognitive score significantly lower when compared with those with a body weight {\\textgreater}5° percentile: 88.8 (6.3) and 100.5 (8.9), respectively. At 12 months, children with unemployed mothers had a mean (SD) motor score significantly lower when compared with those in the other socioeconomic classes: 87.7 (9.8) and 100.6 (12.4), respectively. In conclusion, parents of babies operated on for low-risk EA can be reassured about neurodevelopmental outcome at least up to 1 year of age. When offering a multidisciplinary follow-up program, underweight patients should deserve particular attention to promote their quality of life and support their global development.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus},\n\tauthor = {Aite, L. and Bevilacqua, F. and Zaccara, A. and Ravà, L. and Valfrè, L. and Conforti, A. and Braguglia, A. and Bagolan, P.},\n\tyear = {2014},\n\tpmid = {23980587},\n\tkeywords = {Child Development, Cognition, Cohort Studies, Esophageal Atresia, Female, Humans, Infant, Linear Models, Longitudinal Studies, Male, Motor Skills, Pilot Projects, Prospective Studies, Risk Factors, Socioeconomic Factors, Thinness, esophageal atresia, follow up, neurodevelopmental outcome},\n\tpages = {330--334},\n}\n\n\n\n\n\n\n\n

\n

\n\n\n

\n Data on the neurodevelopmental outcome of esophageal atresia (EA) survivors are scarce, controversial, and based on small samples. This is an observational prospective longitudinal study on a selected cohort of low-risk EA survivors. We considered a low-risk EA survivor a patient with the following characteristics: gestational age \\textgreater32 weeks, no long gap, no genetic or chromosomic anomaly associated with neurodevelopmental delay, and no further major surgical congenital anomalies. Infants were evaluated with scales derived from the Bayley Scales of Infant and Toddler Development - 3rd Edition at 6 and 12 months, with a score of 100 considered normal for each scale. Analysis of variance was used to assess differences of cognitive and motor development. Linear regression was used to assess the impact of the following clinical and sociodemographic variables: gender, birthweight, gestational age, length of hospital stay, number of surgeries and number of esophageal dilatations during first hospitalization, days of mechanical ventilation, weight at follow up, number of surgeries and esophageal dilatations at follow up, parental age, educational level, and socioeconomic status. Thirty children form the object of the study. The mean (standard deviation [SD]) cognitive scale's score was 93.7 (7.5) and 98.2 (9.6) at 6 and 12 months, respectively (P \\textless 0.05). The mean (SD) motor scale's score was 97.6 (9.3) and 98.0 (12.1) at 6 and 12 months, respectively (P = n.s.). Children with a body weight \\textless5° percentile at 12 months showed a mean (SD) cognitive score significantly lower when compared with those with a body weight \\textgreater5° percentile: 88.8 (6.3) and 100.5 (8.9), respectively. At 12 months, children with unemployed mothers had a mean (SD) motor score significantly lower when compared with those in the other socioeconomic classes: 87.7 (9.8) and 100.6 (12.4), respectively. In conclusion, parents of babies operated on for low-risk EA can be reassured about neurodevelopmental outcome at least up to 1 year of age. When offering a multidisciplinary follow-up program, underweight patients should deserve particular attention to promote their quality of life and support their global development.\n

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\n \n\n \n \n \n \n \n \n Management guidelines of eosinophilic esophagitis in childhood.\n \n \n \n \n\n\n \n Papadopoulou, A.; Koletzko, S.; Heuschkel, R.; Dias, J. A.; Allen, K. J.; Murch, S. H.; Chong, S.; Gottrand, F.; Husby, S.; Lionetti, P.; Mearin, M. L.; Ruemmele, F. M.; Schäppi, M. G.; Staiano, A.; Wilschanski, M.; Vandenplas, Y.; ESPGHAN Eosinophilic Esophagitis Working Group; and Committee, t. G.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 58(1): 107–118. January 2014.\n \n\n\n\n
\n\n\n\n \n \n $\"Management$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{papadopoulou_management_2014,\n\ttitle = {Management guidelines of eosinophilic esophagitis in childhood},\n\tvolume = {58},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/24378521/},\n\tdoi = {10.1097/MPG.0b013e3182a80be1},\n\tabstract = {OBJECTIVES: Eosinophilic esophagitis (EoE) represents a chronic, immune/antigen-mediated esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. With few exceptions, 15 eosinophils per high-power field (peak value) in ≥1 biopsy specimens are considered a minimum threshold for a diagnosis of EoE. The disease is restricted to the esophagus, and other causes of esophageal eosinophilia should be excluded, specifically proton pump inhibitor-responsive esophageal eosinophilia. This position paper aims at providing practical guidelines for the management of children and adolescents with EoE.\nMETHODS: Relevant literature from searches of PubMed, CINAHL, and recent guidelines was reviewed. In the absence of an evidence base, recommendations reflect the expert opinion of the authors. Final consensus was obtained during 3 face-to-face meetings of the Gastroenterology Committee and 1 teleconference.\nRESULTS: The cornerstone of treatment is an elimination diet (targeted or empiric elimination diet, amino acid-based formula) and/or swallowed, topical corticosteroids. Systemic corticosteroids are reserved for severe symptoms requiring rapid relief or where other treatments have failed. Esophageal dilatation is an option in children with EoE who have esophageal stenosis unresponsive to drug therapy. Maintenance treatment may be required in case of frequent relapse, although an optimal regimen still needs to be determined.\nCONCLUSIONS: EoE is a chronic, relapsing inflammatory disease with largely unquantified long-term consequences. Investigations and treatment are tailored to the individual and must not create more morbidity for the patient and family than the disease itself. Better maintenance treatment as well as biomarkers for assessing treatment response and predicting long-term complications is urgently needed.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Papadopoulou, A. and Koletzko, S. and Heuschkel, R. and Dias, J. A. and Allen, K. J. and Murch, S. H. and Chong, S. and Gottrand, F. and Husby, S. and Lionetti, P. and Mearin, M. L. and Ruemmele, F. M. and Schäppi, M. G. and Staiano, A. and Wilschanski, M. and Vandenplas, Y. and {ESPGHAN Eosinophilic Esophagitis Working Group and the Gastroenterology Committee}},\n\tmonth = jan,\n\tyear = {2014},\n\tpmid = {24378521},\n\tkeywords = {Adrenal Cortex Hormones, Child, Consensus, Eosinophilic Esophagitis, Eosinophils, Esophageal Stenosis, Esophagus, Humans, Recurrence},\n\tpages = {107--118},\n}\n\n\n\n

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\n \n 2013\n \n \n (15)\n \n \n

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\n \n\n \n \n \n \n \n \n Esophageal atresia: metaplasia, Barrett.\n \n \n \n \n\n\n \n Schneider, A.; Michaud, L.; and Gottrand, F.\n\n\n \n\n\n\n Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus, 26(4): 425–427. 2013.\n \n\n\n\n
\n\n\n\n \n \n $\"Esophageal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{schneider_esophageal_2013,\n\ttitle = {Esophageal atresia: metaplasia, {Barrett}},\n\tvolume = {26},\n\tissn = {1442-2050},\n\tshorttitle = {Esophageal atresia},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23679037/},\n\tdoi = {10.1111/dote.12057},\n\tabstract = {Barrett's esophagus is characterized by the replacement of squamous epithelium by columnar epithelium that is intestinal metaplasia-positive or -negative in the distal esophagus. Gastroesophageal reflux disease, which is frequent and prolonged in esophageal atresia, probably plays a major role in the development of Barrett's esophagus through repeated mucosal damage. Long-term acid exposure contributes to carcinogenesis in Barrett's esophagus of intestinal type, but its effect on gastric metaplasia is less well defined. Recent studies have suggest that metaplasia arises in about 15\\% of patients with esophageal atresia, with a lag time to developing metaplasia from initial surgical correction of about 10 years. Preliminary data from an ongoing multicenter study including 88 patients with esophageal atresia aged 15-19 years showed gastric metaplasia in 42\\% of patients (29 fundic and 7 cardial metaplasia), while one patient presented intestinal metaplasia. Esophageal mucosal abnormalities can be observed in esophageal atresia patients at endoscopy despite the absence of symptoms. Whether prolonged, aggressive, acid suppression is beneficial in these situations remains to be determined. Barrett's metaplasia can be removed by endoscopic mucosal resection or destroyed with endoscopic ablative techniques, such as photodynamic therapy, radiofrequency ablation, and cryotherapy. The risk of developing esophageal carcinoma is still a controversial issue as only a few clinical cases have been reported in young adults with esophageal atresia. As late complications of esophageal atresia, particularly esophagitis and Barrett's esophagus, are increasingly being recognized, long-time systematic follow up of the esophageal mucosa including multistage biopsies is therefore required even in asymptomatic patients.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus},\n\tauthor = {Schneider, A. and Michaud, L. and Gottrand, F.},\n\tyear = {2013},\n\tpmid = {23679037},\n\tkeywords = {Barrett Esophagus, Esophageal Atresia, Esophagoscopy, Humans},\n\tpages = {425--427},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Esophageal atresia: data from a national cohort.\n \n \n \n \n\n\n \n Sfeir, R.; Bonnard, A.; Khen-Dunlop, N.; Auber, F.; Gelas, T.; Michaud, L.; Podevin, G.; Breton, A.; Fouquet, V.; Piolat, C.; Lemelle, J. L.; Petit, T.; Lavrand, F.; Becmeur, F.; Polimerol, M. L.; Michel, J. L.; Elbaz, F.; Habonimana, E.; Allal, H.; Lopez, E.; Lardy, H.; Morineau, M.; Pelatan, C.; Merrot, T.; Delagausie, P.; de Vries, P.; Levard, G.; Buisson, P.; Sapin, E.; Jaby, O.; Borderon, C.; Weil, D.; Gueiss, S.; Aubert, D.; Echaieb, A.; Fourcade, L.; Breaud, J.; Laplace, C.; Pouzac, M.; Duhamel, A.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 48(8): 1664–1669. August 2013.\n \n\n\n\n
\n\n\n\n \n \n $\"Esophageal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{sfeir_esophageal_2013,\n\ttitle = {Esophageal atresia: data from a national cohort},\n\tvolume = {48},\n\tissn = {1531-5037},\n\tshorttitle = {Esophageal atresia},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23932604/},\n\tdoi = {10.1016/j.jpedsurg.2013.03.075},\n\tabstract = {PURPOSE: A prospective national register was established in 2008 to record all new cases of live-birth newborns with esophageal atresia (EA). This epidemiological survey was recommended as part of a national rare diseases plan.\nMETHODS: All 38 national centers treating EA participated by completing for each patient at first discharge a questionnaire validated by a national committee of experts. Data were centralized by the national reference center for esophageal anomalies. Quantitative and qualitative analyses were performed, with P-values of less than 0.05 considered statistically significant. Results of the 2008-2009 data collection are presented in this report.\nRESULTS: Three hundred seven new living cases of EA were recorded between January 1, 2008, and December 31, 2009. The male/female sex ratio was 1.3, and the live-birth prevalence of EA was 1.8 per 10,000 births. Major characteristics were comparable to those reported in the literature. Survival was 95\\%, and no correlation with caseload was noted.\nCONCLUSIONS: Epidemiologic surveys of congenital anomalies such as EA, which is a rare disease, provide valuable data for public health authorities and fulfill one important mission of reference centers. When compared with previous epidemiological data, this national population-based registry suggests that the incidence of EA remains stable.},\n\tlanguage = {eng},\n\tnumber = {8},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Sfeir, Rony and Bonnard, Arnaud and Khen-Dunlop, Naziha and Auber, Frederic and Gelas, Thomas and Michaud, Laurent and Podevin, Guillaume and Breton, Anne and Fouquet, Virginie and Piolat, Christian and Lemelle, Jean Louis and Petit, Thierry and Lavrand, Frederic and Becmeur, Francis and Polimerol, Marie Laurence and Michel, Jean Luc and Elbaz, Frederic and Habonimana, Eric and Allal, Hassan and Lopez, Emmanuel and Lardy, Hubert and Morineau, Marianne and Pelatan, Cécile and Merrot, Thierry and Delagausie, Pascal and de Vries, Philline and Levard, Guillaume and Buisson, Phillippe and Sapin, Emmanuel and Jaby, Olivier and Borderon, Corinne and Weil, Dominique and Gueiss, Stephane and Aubert, Didier and Echaieb, Anais and Fourcade, Laurent and Breaud, Jean and Laplace, Christophe and Pouzac, Myriam and Duhamel, Alain and Gottrand, Frederic},\n\tmonth = aug,\n\tyear = {2013},\n\tpmid = {23932604},\n\tkeywords = {Abnormalities, Multiple, Adolescent, Adult, Birth Weight, Cohort Studies, Cohort study, Combined Modality Therapy, Epidemiology, Esophageal Atresia, Esophageal atresia, Female, France, Gestational Age, Humans, Incidence, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Maternal Age, Middle Aged, Neonatal surgery, Polyhydramnios, Population Surveillance, Population-based registry, Pregnancy, Prenatal Diagnosis, Prenatal diagnosis, Prevalence, Prospective Studies, Rare disease, Registries, Surveys and Questionnaires, Survival Rate, Workload, Young Adult},\n\tpages = {1664--1669},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Epidemiology of esophageal atresia.\n \n \n \n \n\n\n \n Sfeir, R.; Michaud, L.; Salleron, J.; and Gottrand, F.\n\n\n \n\n\n\n Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus, 26(4): 354–355. 2013.\n \n\n\n\n
\n\n\n\n \n \n $\"Epidemiology$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{sfeir_epidemiology_2013,\n\ttitle = {Epidemiology of esophageal atresia},\n\tvolume = {26},\n\tissn = {1442-2050},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23679022/},\n\tdoi = {10.1111/dote.12051},\n\tabstract = {Esophageal atresia (EA) is a rare congenital malformation consisting of a lack of continuity between the upper and lower esophageal pouches, frequently associated with tracheoesophageal fistula. The prevalence of such rare abnormalities is established by global birth surveillance programs over the world. EUROCAT is a European program covering 1.7 million births since its creation. The prevalence of EA in Europe seems stable over decades. The National Birth Defects Prevention Network in the USA also shows a stable prevalence with a wide range between states or regions. In France, with the implementation of the national rare diseases plan, a reference center for congenital abnormalities of the esophagus was created in 2006 and a national registry for EA began patient inclusion in 2008. This has resulted in the establishment of the national live birth prevalence for EA, prenatal diagnosis rates, and clinical characteristics of EA patients, early survival, and early morbidity. Prevalence rates seem stable all over the world since many decades. Continuous surveillance of congenital abnormalities and specific registries are useful for epidemiologic data but also for public health authorities for helping families of rare diseases patients.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus},\n\tauthor = {Sfeir, R. and Michaud, L. and Salleron, J. and Gottrand, F.},\n\tyear = {2013},\n\tpmid = {23679022},\n\tkeywords = {Esophageal Atresia, Europe, Female, Global Health, Humans, Population Surveillance, Pregnancy, Prenatal Diagnosis, Prevalence, Registries, United States},\n\tpages = {354--355},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Characteristics and management of congenital esophageal stenosis: findings from a multicenter study.\n \n \n \n \n\n\n \n Michaud, L.; Coutenier, F.; Podevin, G.; Bonnard, A.; Becmeur, F.; Khen-Dunlop, N.; Auber, F.; Maurel, A.; Gelas, T.; Dassonville, M.; Borderon, C.; Dabadie, A.; Weil, D.; Piolat, C.; Breton, A.; Djeddi, D.; Morali, A.; Bastiani, F.; Lamireau, T.; and Gottrand, F.\n\n\n \n\n\n\n Orphanet Journal of Rare Diseases, 8: 186. December 2013.\n \n\n\n\n
\n\n\n\n \n \n $\"Characteristics$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{michaud_characteristics_2013,\n\ttitle = {Characteristics and management of congenital esophageal stenosis: findings from a multicenter study},\n\tvolume = {8},\n\tissn = {1750-1172},\n\tshorttitle = {Characteristics and management of congenital esophageal stenosis},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/24289834/},\n\tdoi = {10.1186/1750-1172-8-186},\n\tabstract = {BACKGROUND: Congenital esophageal stenosis (CES) is a rare condition frequently associated with esophageal atresia (EA). There are limited data from small series about the presentation, treatment, and outcomes of CES.\nMETHODS: Medical records of all patients with CES included in the French Network on Esophageal Malformations and Congenital Diseases were reviewed retrospectively with regard to diagnosis, treatment, and outcome.\nRESULTS: Over 18 years, 61 patients (30 boys) had CES, and 29 (47\\%) of these patients also had EA. The mean age at diagnosis was 24 months (1 day to 14 years) and was younger in patients with CES and EA than in those with isolated CES (7 vs. 126 months, p {\\textless} 0.05). Twenty-one of the 61 patients with CES had no clinical symptoms: in three patients, the findings were incidental, and in 18 of the 29 patients with associated EA, CES was diagnosed at the time of surgical repair of EA or during a postoperative systematic esophageal barium study. In the 40 other patients, at diagnosis, 50\\% presented with dysphasia, 40\\% with vomiting, 50\\% with food impaction, and 42\\% with respiratory symptoms. Diagnosis of CES was confirmed by esophageal barium study (56/61) and/or esophageal endoscopy (50/61). Sixteen patients had tracheobronchial remnants (TBR), 40 had fibromuscular stenosis (FMS), and five had membrane stenosis (MS). Thirty-four patients (56\\%) were treated by dilation only (13/34 remained asymptomatic at follow-up); 15 patients were treated by dilation but required later surgery because of failure (4/15 remained asymptomatic at follow-up); and nine patients had a primary surgical intervention (4/9 were asymptomatic at follow-up). Dilation was complicated by esophageal perforation in two patients (3.4\\%). At follow-up, dysphagia remained in 36\\% (21/58) of patients, but the incidence did not differ between the EA and the isolated CS groups (10/29 vs. 7/32, p = 0.27).\nCONCLUSIONS: CS diagnosis can be delayed when associated with EA. Dilation may be effective for treating patients with FMS and MS, but surgical repair is often required for those with TBR. Our results show clearly that, regardless of the therapeutic option, dysphagia occurs frequently, and patients with CES should be followed over the long term.},\n\tlanguage = {eng},\n\tjournal = {Orphanet Journal of Rare Diseases},\n\tauthor = {Michaud, Laurent and Coutenier, Frédéric and Podevin, Guillaume and Bonnard, Arnaud and Becmeur, François and Khen-Dunlop, Naziha and Auber, Frédéric and Maurel, Aude and Gelas, Thomas and Dassonville, Martine and Borderon, Corinne and Dabadie, Alain and Weil, Dominique and Piolat, Christian and Breton, Anne and Djeddi, Djamal and Morali, Alain and Bastiani, Florence and Lamireau, Thierry and Gottrand, Frédéric},\n\tmonth = dec,\n\tyear = {2013},\n\tpmid = {24289834},\n\tpmcid = {PMC4222067},\n\tkeywords = {Adolescent, Child, Child, Preschool, Esophageal Atresia, Esophageal Stenosis, Female, Humans, Infant, Infant, Newborn, Male, Retrospective Studies},\n\tpages = {186},\n}\n\n\n\n

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\n BACKGROUND: Congenital esophageal stenosis (CES) is a rare condition frequently associated with esophageal atresia (EA). There are limited data from small series about the presentation, treatment, and outcomes of CES. METHODS: Medical records of all patients with CES included in the French Network on Esophageal Malformations and Congenital Diseases were reviewed retrospectively with regard to diagnosis, treatment, and outcome. RESULTS: Over 18 years, 61 patients (30 boys) had CES, and 29 (47%) of these patients also had EA. The mean age at diagnosis was 24 months (1 day to 14 years) and was younger in patients with CES and EA than in those with isolated CES (7 vs. 126 months, p \\textless 0.05). Twenty-one of the 61 patients with CES had no clinical symptoms: in three patients, the findings were incidental, and in 18 of the 29 patients with associated EA, CES was diagnosed at the time of surgical repair of EA or during a postoperative systematic esophageal barium study. In the 40 other patients, at diagnosis, 50% presented with dysphasia, 40% with vomiting, 50% with food impaction, and 42% with respiratory symptoms. Diagnosis of CES was confirmed by esophageal barium study (56/61) and/or esophageal endoscopy (50/61). Sixteen patients had tracheobronchial remnants (TBR), 40 had fibromuscular stenosis (FMS), and five had membrane stenosis (MS). Thirty-four patients (56%) were treated by dilation only (13/34 remained asymptomatic at follow-up); 15 patients were treated by dilation but required later surgery because of failure (4/15 remained asymptomatic at follow-up); and nine patients had a primary surgical intervention (4/9 were asymptomatic at follow-up). Dilation was complicated by esophageal perforation in two patients (3.4%). At follow-up, dysphagia remained in 36% (21/58) of patients, but the incidence did not differ between the EA and the isolated CS groups (10/29 vs. 7/32, p = 0.27). CONCLUSIONS: CS diagnosis can be delayed when associated with EA. Dilation may be effective for treating patients with FMS and MS, but surgical repair is often required for those with TBR. Our results show clearly that, regardless of the therapeutic option, dysphagia occurs frequently, and patients with CES should be followed over the long term.\n

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\n \n\n \n \n \n \n \n \n Barrett esophagus and esophagojejunal anastomotic stenosis as complications of esophagogastric disconnection in children with esophageal atresia.\n \n \n \n \n\n\n \n Gottrand, M.; Michaud, L.; Guimber, D.; Coopman, S.; Sfeir, R.; Bonnevalle, M.; Leteurtre, E.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 57(1): 93–95. July 2013.\n \n\n\n\n
\n\n\n\n \n \n $\"Barrett$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gottrand_barrett_2013,\n\ttitle = {Barrett esophagus and esophagojejunal anastomotic stenosis as complications of esophagogastric disconnection in children with esophageal atresia},\n\tvolume = {57},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23535759/},\n\tdoi = {10.1097/MPG.0b013e3182929ec2},\n\tabstract = {Total esophagogastric disconnection (TED) is an alternative surgical procedure in resistant gastroesophageal reflux disease. We report 2 severe, not yet described long-term complications of TED occurring in 4 children with a history of esophageal atresia. Three children presented with stenosis of the esophagojejunal anastomosis 5 months to 9 years after TED, requiring repeated dilations associated with mitomycin C application in one of them. Barrett esophagus was observed in 3 children 8 to 9 years after TED. Careful long-term clinical and endoscopic follow-up of children who underwent TED is required.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Gottrand, Madeleine and Michaud, Laurent and Guimber, Dominique and Coopman, Stéphanie and Sfeir, Rony and Bonnevalle, Michel and Leteurtre, Emmanuelle and Gottrand, Frédéric},\n\tmonth = jul,\n\tyear = {2013},\n\tpmid = {23535759},\n\tkeywords = {Barrett Esophagus, Child, Child, Preschool, Esophageal Atresia, Esophageal Stenosis, Esophagogastric Junction, France, Humans, Male, Postoperative Complications, Severity of Illness Index},\n\tpages = {93--95},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n Chromosome aberrations and gene mutations in patients with esophageal atresia.\n \n \n \n\n\n \n Bednarczyk, D.; Sasiadek, M. M.; and Smigiel, R.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 57(6): 688–693. December 2013.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{bednarczyk_chromosome_2013,\n\ttitle = {Chromosome aberrations and gene mutations in patients with esophageal atresia},\n\tvolume = {57},\n\tissn = {1536-4801},\n\tdoi = {10.1097/MPG.0b013e3182a373dc},\n\tabstract = {Esophageal atresia (EA) is one of the most frequent congenital malformations of the gastrointestinal tract. Many genetic alterations in patients with EA have been described in the literature. It is thought that the etiology of EA is heterogeneous. This review of the literature provides detailed information about chromosomal aberrations, gene mutations, and clinical features of neonates with EA, and serves as an excellent source to compare newly diagnosed patients with those described in the literature.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Bednarczyk, Damian and Sasiadek, Maria M. and Smigiel, Robert},\n\tmonth = dec,\n\tyear = {2013},\n\tpmid = {23857338},\n\tkeywords = {Chromosome Aberrations, Esophageal Atresia, Esophagus, Humans, Mutation, Tracheoesophageal Fistula},\n\tpages = {688--693},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Esophagitis with eosinophil infiltration associated with congenital esophageal atresia and stenosis.\n \n \n \n\n\n \n Yamada, Y.; Nishi, A.; Kato, M.; Toki, F.; Yamamoto, H.; Suzuki, N.; Hirato, J.; and Hayashi, Y.\n\n\n \n\n\n\n International Archives of Allergy and Immunology, 161 Suppl 2: 159–163. 2013.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{yamada_esophagitis_2013,\n\ttitle = {Esophagitis with eosinophil infiltration associated with congenital esophageal atresia and stenosis},\n\tvolume = {161 Suppl 2},\n\tissn = {1423-0097},\n\tdoi = {10.1159/000350400},\n\tabstract = {BACKGROUND: The esophagus is physiologically devoid of eosinophils, so their presence would suggest some underlying pathology. The prevalence of eosinophilic esophagitis (EoE) has steadily increased in Western countries. Previous studies have described EoE in association with congenital esophageal atresia (CEA), which is the most common congenital anomaly of the esophagus. However, the association remains unclear.\nMETHODS: We performed a retrospective histological analysis examining for eosinophil infiltration in the esophagus of patients with CEA following surgical repair or congenital esophageal stenosis (CES) who underwent esophageal biopsy or surgical resection in our hospital between 2005 and 2012.\nRESULTS: There were 6 patients with CEA following surgical repair or CES who had eosinophil-dominant infiltration in the esophagus. All had associated allergic disorders, including food allergies in 4. Moreover, all except for one fulfilled the histological criteria of EoE. Impairment of eosinophil infiltration and symptomatic improvement were observed in those treated with a proton pump inhibitor (PPI), either alone or in combination with steroids after esophageal dilatation.\nCONCLUSIONS: These findings suggest that CEA repair or CES in conjunction with allergic conditions and coexisting gastroesophageal reflux disease (GERD) may induce greater esophageal eosinophilic inflammation. In addition, esophageal dilatation followed by PPI treatment, alone or with steroids, may be a therapeutic strategy that can provide symptomatic relief by reducing eosinophilic inflammation in esophageal strictures or GERD associated with CEA or CES.},\n\tlanguage = {eng},\n\tjournal = {International Archives of Allergy and Immunology},\n\tauthor = {Yamada, Yoshiyuki and Nishi, Akira and Kato, Masahiko and Toki, Fumiaki and Yamamoto, Hideki and Suzuki, Norio and Hirato, Junko and Hayashi, Yasuhide},\n\tyear = {2013},\n\tpmid = {23711868},\n\tkeywords = {Adolescent, Child, Child, Preschool, Eosinophilic Esophagitis, Esophageal Atresia, Esophageal Stenosis, Esophagoscopy, Female, Humans, Infant, Male, Retrospective Studies},\n\tpages = {159--163},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n [Medium-term outcome, follow-up, and quality of life in children treated for type III esophageal atresia].\n \n \n \n\n\n \n Lepeytre, C.; De Lagausie, P.; Merrot, T.; Baumstarck, K.; Oudyi, M.; and Dubus, J.\n\n\n \n\n\n\n Archives De Pediatrie: Organe Officiel De La Societe Francaise De Pediatrie, 20(10): 1096–1104. October 2013.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{lepeytre_medium-term_2013,\n\ttitle = {[{Medium}-term outcome, follow-up, and quality of life in children treated for type {III} esophageal atresia]},\n\tvolume = {20},\n\tissn = {1769-664X},\n\tdoi = {10.1016/j.arcped.2013.06.035},\n\tabstract = {The aim of this study was to evaluate the medium-term outcome (health status, medical and surgical French National Health Authority-recommended follow-up, and quality of life) of children born with type III esophageal atresia (EA). Previous events (during the perinatal period, associated abnormalities, respiratory and digestive complications) of children treated for type III EA at the Marseille university hospitals between 1999 and 2009 were noted. Parents completed a standardized questionnaire concerning the health of their children during the previous year, and a quality-of-life questionnaire (PedsQL 4.0) was also completed by children aged more than 8 years. Among the 68 children treated, 44 responded to our solicitation (mean age, 7.6 years; range, 3-12.8 years). Previous important events were : pneumonia(s) (65\\%), asthma before the age of 3 years (66\\%), hospitalization for a respiratory event (45\\%), fundoplication (20\\%), and esophageal dilatation (45\\%). We noted current chronic cough (16\\%), asthma (30\\%), dysphagia (39\\%), and symptomatic gastroesophageal reflux (9\\%). National guidelines were not respected, except for the surgical indications in children aged less than 6 years. The quality-of-life scores (n=43 children) were similar to healthy controls but were negatively influenced by a gastrostomy procedure (P=0.020), pneumonia (P=0.013), and hospitalization due to a respiratory event (P=0.006) or a digestive event (P=0.010), and also by current asthma (P=0.004). In conclusion, despite recurrent respiratory or digestive symptoms and inadequate recommended follow-up, the quality of life of children treated for type III of EA is good.},\n\tlanguage = {fre},\n\tnumber = {10},\n\tjournal = {Archives De Pediatrie: Organe Officiel De La Societe Francaise De Pediatrie},\n\tauthor = {Lepeytre, C. and De Lagausie, P. and Merrot, T. and Baumstarck, K. and Oudyi, M. and Dubus, J.-C.},\n\tmonth = oct,\n\tyear = {2013},\n\tpmid = {23932659},\n\tkeywords = {Body Mass Index, Child, Child, Preschool, Deglutition Disorders, Esophageal Atresia, Female, Follow-Up Studies, Gastrostomy, Humans, Male, Patient Outcome Assessment, Quality of Life, Respiratory Tract Diseases, Surveys and Questionnaires},\n\tpages = {1096--1104},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Long-term outcome of esophageal anastomosis.\n \n \n \n\n\n \n Rintala, R. J.; and Pakarinen, M. P.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 23(3): 219–225. June 2013.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{rintala_long-term_2013,\n\ttitle = {Long-term outcome of esophageal anastomosis},\n\tvolume = {23},\n\tissn = {1439-359X},\n\tdoi = {10.1055/s-0033-1347912},\n\tabstract = {After repair of esophageal atresia (EA) in a newborn, esophageal dysmotility presenting as dysphagia and symptomatic gastroesophageal reflux are common. Significant esophageal morbidity associated with EA extends into adulthood. In adulthood approximately one-fifth of the patients have developed epithelial metaplastic changes, one-third of these have intestinal metaplasia (Barrett esophagus). Surgical complications, increasing age, and impaired esophageal motility predict the development of epithelial metaplasia after repair of EA. To date, worldwide, eight cases of esophageal cancer have been reported in young adults treated for EA. Incidence of esophageal cancer after EA repair is very much likely to increase in the future. Life-long endoscopic follow-up is warranted in patients with EA.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Rintala, R. J. and Pakarinen, M. P.},\n\tmonth = jun,\n\tyear = {2013},\n\tpmid = {23737132},\n\tkeywords = {Anastomosis, Surgical, Esophageal Atresia, Esophagus, Follow-Up Studies, Humans, Postoperative Complications, Time Factors, Treatment Outcome},\n\tpages = {219--225},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Long-gap esophageal atresia: traction-growth and anastomosis - before and beyond.\n \n \n \n\n\n \n Bagolan, P.; Valfrè, L.; Morini, F.; and Conforti, A.\n\n\n \n\n\n\n Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus, 26(4): 372–379. 2013.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{bagolan_long-gap_2013,\n\ttitle = {Long-gap esophageal atresia: traction-growth and anastomosis - before and beyond},\n\tvolume = {26},\n\tissn = {1442-2050},\n\tshorttitle = {Long-gap esophageal atresia},\n\tdoi = {10.1111/dote.12050},\n\tabstract = {Long-gap esophageal atresia (LGEA) is still a major surgical challenge. Options for esophageal reconstruction include the use of native esophagus or esophageal replacement with stomach, colon, or small intestine. Nonetheless, there is a consensus among most pediatric surgeons that the preservation of the native esophagus is associated with better postoperative outcomes. Thus, every effort should be made to conserve the native esophagus. The present study is aimed at critically reporting our experience focused on a standardized protocol based on the preoperative assessment of the gap in all cases and reviewing the present literature because no consensus is available regarding many aspects of LGEA (from definition to treatment). All newborn infants treated since 1995 for esophageal atresia (EA), regardless of type, were included in the present study. Identification of LGEA patients (gap ≥3 vertebral bodies) was performed based on preoperative esophageal gap measurement. The selected patients were grouped based on EA type (A/B vs. C/D) and whether they were referred from an outside institution or not. Postoperative outcome was compared. Statistical analysis was performed with the Fisher's exact test and Mann-Whitney test as appropriate, with P {\\textless} 0.05 considered statistically significant. Two hundred and nineteen patients have been consecutively treated between 1995 and 2012 with the following EA subtypes: type: A 25 (11.4\\%); B 6 (2.7\\%); C 182 (83.1\\%); D 3 (1.4\\%); E 3 (1.4\\%). Fifty-seven patients (26\\%) were classified as LGEA: type A-B, 31 (54.4\\%); type C-D, 26 (45.6\\%). Twenty seven (47\\%) of these patients were referred after at least one failed attempt at esophageal correction: type A-B, 15 (55\\%); type C-D, 12 (45\\%). Only one patient ultimately required esophageal substitution, with an overall survival rate of 94\\%. A standardized perioperative protocol enhances the possibility of preserving the native esophagus in cases of LGEA. Gap measurement can be accurately defined before surgery in all patients with EA. Esophageal anastomosis (either immediate or delayed repair) is almost always feasible; esophageal substitution should only be considered after a rigorous attempt at achieving end-to-end esophageal anastomosis.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus},\n\tauthor = {Bagolan, P. and Valfrè, L. and Morini, F. and Conforti, A.},\n\tyear = {2013},\n\tpmid = {23679026},\n\tkeywords = {Anastomosis, Surgical, Clinical Protocols, Esophageal Atresia, Esophagoplasty, Esophagus, Humans, Infant, Newborn, Postoperative Complications, Preoperative Care, Tissue Expansion, Tracheoesophageal Fistula, Treatment Outcome},\n\tpages = {372--379},\n}\n\n\n\n\n\n\n\n

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\n Long-gap esophageal atresia (LGEA) is still a major surgical challenge. Options for esophageal reconstruction include the use of native esophagus or esophageal replacement with stomach, colon, or small intestine. Nonetheless, there is a consensus among most pediatric surgeons that the preservation of the native esophagus is associated with better postoperative outcomes. Thus, every effort should be made to conserve the native esophagus. The present study is aimed at critically reporting our experience focused on a standardized protocol based on the preoperative assessment of the gap in all cases and reviewing the present literature because no consensus is available regarding many aspects of LGEA (from definition to treatment). All newborn infants treated since 1995 for esophageal atresia (EA), regardless of type, were included in the present study. Identification of LGEA patients (gap ≥3 vertebral bodies) was performed based on preoperative esophageal gap measurement. The selected patients were grouped based on EA type (A/B vs. C/D) and whether they were referred from an outside institution or not. Postoperative outcome was compared. Statistical analysis was performed with the Fisher's exact test and Mann-Whitney test as appropriate, with P \\textless 0.05 considered statistically significant. Two hundred and nineteen patients have been consecutively treated between 1995 and 2012 with the following EA subtypes: type: A 25 (11.4%); B 6 (2.7%); C 182 (83.1%); D 3 (1.4%); E 3 (1.4%). Fifty-seven patients (26%) were classified as LGEA: type A-B, 31 (54.4%); type C-D, 26 (45.6%). Twenty seven (47%) of these patients were referred after at least one failed attempt at esophageal correction: type A-B, 15 (55%); type C-D, 12 (45%). Only one patient ultimately required esophageal substitution, with an overall survival rate of 94%. A standardized perioperative protocol enhances the possibility of preserving the native esophagus in cases of LGEA. Gap measurement can be accurately defined before surgery in all patients with EA. Esophageal anastomosis (either immediate or delayed repair) is almost always feasible; esophageal substitution should only be considered after a rigorous attempt at achieving end-to-end esophageal anastomosis.\n

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\n \n\n \n \n \n \n \n Early developmental outcome following surgery for oesophageal atresia.\n \n \n \n\n\n \n Walker, K.; Halliday, R.; Badawi, N.; Stewart, J.; and Holland, A. J.\n\n\n \n\n\n\n Journal of Paediatrics and Child Health, 49(6): 467–470. June 2013.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{walker_early_2013,\n\ttitle = {Early developmental outcome following surgery for oesophageal atresia},\n\tvolume = {49},\n\tissn = {1440-1754},\n\tdoi = {10.1111/jpc.12206},\n\tabstract = {AIM: To compare the developmental outcome of infants with oesophageal atresia with or without trachea-oesophageal fistula (OA/TOF) who underwent surgery in early infancy with healthy control infants in New South Wales, Australia.\nMETHODS: Infants diagnosed with OA/TOF requiring surgical intervention were enrolled prospectively between 1 August 2006 and the 31 December 2008. Healthy control infants were enrolled in the same time period. The children underwent a developmental assessment at 1 year of age (corrected) using the Bayley Scales of Infant and Toddler Development (Version III).\nRESULTS: Of 34 infants with OA/TOF that were enrolled, 31 had developmental assessments. The majority (75\\%) were term infants (≥37 weeks gestation) with a mean birth weight of 2717 g. Fourteen infants (44\\%) had an associated birth defect and one infant with multiple associated anomalies subsequently died. Developmental assessments were also performed on 62 control infants matched for gestational age. Infants with OA/TOF had a mean score significantly lower on the expressive language subscale (P {\\textless} 0.05) compared with the control infants.\nCONCLUSIONS: This study found a lower than expected developmental score for infants following surgery for OA/TOF in the expressive language subscale compared with the healthy control infants. These findings support concerns over the potential impact of OA/TOF and its effects on development. Further studies, including continuing developmental review to determine whether these differences persist and their functional importance, should be performed.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Journal of Paediatrics and Child Health},\n\tauthor = {Walker, Karen and Halliday, Robert and Badawi, Nadia and Stewart, Jan and Holland, Andrew Ja},\n\tmonth = jun,\n\tyear = {2013},\n\tpmid = {23600846},\n\tkeywords = {Case-Control Studies, Child Development, Child Language, Developmental Disabilities, Esophageal Atresia, Humans, Infant, Prospective Studies, Tracheoesophageal Fistula, Treatment Outcome},\n\tpages = {467--470},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n Peroral endoscopic myotomy for the treatment of achalasia in children.\n \n \n \n\n\n \n Familiari, P.; Marchese, M.; Gigante, G.; Boskoski, I.; Tringali, A.; Perri, V.; and Costamagna, G.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 57(6): 794–797. December 2013.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{familiari_peroral_2013,\n\ttitle = {Peroral endoscopic myotomy for the treatment of achalasia in children},\n\tvolume = {57},\n\tissn = {1536-4801},\n\tdoi = {10.1097/MPG.0b013e3182a803f7},\n\tabstract = {Peroral endoscopic myotomy (POEM) is a new endoscopic technique for the treatment of esophageal achalasia, with excellent results in adults. Three children with classic-type achalasia (mean age 9.6 years) underwent POEM in a single center. Mean basal lower esophageal sphincter pressure and Eckard score were 34.6 mmHg and 5.3, respectively. Mean length of myotomy was 10 cm. On average, POEM was completed in 60.6 minutes. No patients experienced postoperative complications or gastroesophageal reflux disease. In the 2 patients who completed a 12-month follow-up, complete symptoms relief was documented (Eckard score 0), as well as a significant drop of the basal lower esophageal sphincter pressure.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Familiari, Pietro and Marchese, Michele and Gigante, Giovanni and Boskoski, Ivo and Tringali, Andrea and Perri, Vincenzo and Costamagna, Guido},\n\tmonth = dec,\n\tyear = {2013},\n\tpmid = {23941997},\n\tkeywords = {Child, Esophageal Achalasia, Esophageal Sphincter, Lower, Esophagoscopy, Female, Follow-Up Studies, Gastroesophageal Reflux, Humans, Incidence, Muscles, Postoperative Complications, Pressure, Treatment Outcome},\n\tpages = {794--797},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Traffic-related air pollution and selected birth defects in the San Joaquin Valley of California.\n \n \n \n\n\n \n Padula, A. M.; Tager, I. B.; Carmichael, S. L.; Hammond, S. K.; Yang, W.; Lurmann, F. W.; and Shaw, G. M.\n\n\n \n\n\n\n Birth Defects Research. Part A, Clinical and Molecular Teratology, 97(11): 730–735. November 2013.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{padula_traffic-related_2013,\n\ttitle = {Traffic-related air pollution and selected birth defects in the {San} {Joaquin} {Valley} of {California}},\n\tvolume = {97},\n\tissn = {1542-0760},\n\tdoi = {10.1002/bdra.23175},\n\tabstract = {BACKGROUND: Birth defects are a leading cause of infant morbidity and mortality. Studies suggest associations between environmental contaminants and some structural anomalies, although evidence is limited and several anomalies have not been investigated previously.\nMETHODS: We used data from the California Center of the National Birth Defects Prevention Study and the Children's Health and Air Pollution Study to estimate the odds of 26 congenital birth defect phenotypes with respect to quartiles of seven ambient air pollutant and traffic exposures in California during the first 2 months of pregnancy, 1997 to 2006 (874 cases and 849 controls). We calculated odds ratios (adjusted for maternal race/ethnicity, education, and vitamin use; aOR) for 11 phenotypes that had at least 40 cases.\nRESULTS: Few odds ratios had confidence intervals that did not include 1.0. Odds of esophageal atresia were increased for the highest versus lowest of traffic density (aOR = 2.8, 95\\% confidence interval [CI], 1.1-7.4) and PM10 exposure (aOR 4.9; 95\\% CI, 1.4-17.2). PM₁₀ was associated with a decreased risk of hydrocephaly (aOR= 0.3; 95\\% CI, 0.1-0.9) and CO with decreased risk of anotia/microtia (aOR = 0.4; 95\\% CI, 0.2-0.8) and transverse limb deficiency (aOR = 0.4; 95\\% CI, 0.2-0.9), again reflecting highest versus lowest quartile comparisons.\nCONCLUSION: Most analyses showed no substantive association between air pollution and the selected birth defects with few exceptions of mixed results.},\n\tlanguage = {eng},\n\tnumber = {11},\n\tjournal = {Birth Defects Research. Part A, Clinical and Molecular Teratology},\n\tauthor = {Padula, Amy M. and Tager, Ira B. and Carmichael, Suzan L. and Hammond, S. Katharine and Yang, Wei and Lurmann, Frederick W. and Shaw, Gary M.},\n\tmonth = nov,\n\tyear = {2013},\n\tpmid = {24108522},\n\tpmcid = {PMC4264633},\n\tkeywords = {Adult, Air Pollutants, Air Pollution, California, Congenital Abnormalities, Congenital Microtia, Ear, Female, Humans, Hydrocephalus, Maternal Exposure, Pregnancy, Retrospective Studies, air pollution, birth outcomes, congenital anomalies, traffic},\n\tpages = {730--735},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Micronutrient status of children receiving prolonged enteral nutrition.\n \n \n \n \n\n\n \n Gottrand, M.; Muyshont, L.; Couttenier, F.; Beghin, L.; Martigne, L.; Coopman, S.; Turck, D.; Michaud, L.; Guimber, D.; and Gottrand, F.\n\n\n \n\n\n\n Annals of Nutrition & Metabolism, 63(1-2): 152–158. 2013.\n \n\n\n\n
\n\n\n\n \n \n $\"Micronutrient$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gottrand_micronutrient_2013,\n\ttitle = {Micronutrient status of children receiving prolonged enteral nutrition},\n\tvolume = {63},\n\tissn = {1421-9697},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/24008240/},\n\tdoi = {10.1159/000353704},\n\tabstract = {BACKGROUND AND AIMS: The aim of this study was to assess the micronutrient status of children receiving prolonged enteral nutrition.\nMETHODS: This cross-sectional single-center study included all 64 children (median age 6.8 years) receiving enteral nutrition providing {\\textgreater}50\\% of daily energy intake for more than 6 months (median duration of enteral nutrition 43 months). The characteristics of the patients and mode of enteral nutrition were recorded. The concentrations of iron, zinc, copper, selenium and vitamins A, D, E and C were measured in plasma.\nRESULTS: Twelve children (19\\%) had iron deficiency. A high 25-hydroxyvitamin D concentration was recorded in 20\\% of the children, but none had associated hypercalcemia. Fifty-two children (81\\%) had low zinc concentrations in both plasma and erythrocytes. Plasma zinc, calcium, phosphorus and vitamin D concentrations were significantly lower in children receiving fiber supplementation. Abnormal micronutrient concentrations were found more frequently in the children receiving fiber supplementation. No other predisposing factors were associated with micronutrient deficiencies.\nCONCLUSION: Long-term enteral nutrition can lead to micronutrient deficiencies in children, whose micronutrient concentrations may require regular checking. Fiber supplementation might reduce the bioavailability of zinc, calcium, phosphorus and vitamin D.},\n\tlanguage = {eng},\n\tnumber = {1-2},\n\tjournal = {Annals of Nutrition \\& Metabolism},\n\tauthor = {Gottrand, M. and Muyshont, L. and Couttenier, F. and Beghin, L. and Martigne, L. and Coopman, S. and Turck, D. and Michaud, L. and Guimber, D. and Gottrand, F.},\n\tyear = {2013},\n\tpmid = {24008240},\n\tkeywords = {Adolescent, Ascorbic Acid, Body Height, Body Weight, Child, Child, Preschool, Copper, Cross-Sectional Studies, Dietary Fiber, Dietary Supplements, Energy Intake, Enteral Nutrition, Female, Follow-Up Studies, Humans, Infant, Iron, Dietary, Male, Micronutrients, Nutritional Status, Selenium, Time Factors, Vitamin A, Vitamin D, Zinc},\n\tpages = {152--158},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n In vitro development and characterization of a tissue-engineered conduit resembling esophageal wall using human and pig skeletal myoblast, oral epithelial cells, and biologic scaffolds.\n \n \n \n \n\n\n \n Poghosyan, T.; Gaujoux, S.; Vanneaux, V.; Bruneval, P.; Domet, T.; Lecourt, S.; Jarraya, M.; Sfeir, R.; Larghero, J.; and Cattan, P.\n\n\n \n\n\n\n Tissue Engineering. Part A, 19(19-20): 2242–2252. October 2013.\n \n\n\n\n
\n\n\n\n \n \n $\"In$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{poghosyan_vitro_2013,\n\ttitle = {In vitro development and characterization of a tissue-engineered conduit resembling esophageal wall using human and pig skeletal myoblast, oral epithelial cells, and biologic scaffolds},\n\tvolume = {19},\n\tissn = {1937-335X},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23672649/},\n\tdoi = {10.1089/ten.TEA.2012.0565},\n\tabstract = {INTRODUCTION: Tissue engineering represents a promising approach for esophageal replacement, considering the complexity and drawbacks of conventional techniques.\nAIM: To create the components necessary to reconstruct in vitro or in vivo an esophageal wall, we analyzed the feasibility and the optimal conditions of human and pig skeletal myoblast (HSM and PSM) and porcine oral epithelial cell (OEC) culture on biologic scaffolds.\nMATERIALS AND METHODS: PSM and HSM were isolated from striated muscle and porcine OECs were extracted from oral mucosa biopsies. Myoblasts were seeded on an acellular scaffold issue from porcine small intestinal submucosa (SIS) and OEC on decellularized human amniotic membrane (HAM). Seeding conditions (cell concentrations [0.5×10(6) versus 10(6) cells/cm(2)] and culture periods [7, 14 and 21 days]), were analyzed using the methyl thiazoltetrazolium assay, quantitative PCR, flow cytometry, and immunohistochemistry.\nRESULTS: Phenotypic stability was observed after cellular expansion for PSM and HSM (85\\% and 97\\% CD56-positive cells, respectively), and OECs (90\\% AE1/AE3- positive cells). After PSM and HSM seeding, quantities of viable cells were similar whatever the initial cell concentration used and remained stable at all time points. During cell culture on SIS, a decrease of CD56-positive cells was observed (76\\% and 76\\% by D7, 56\\% and 70\\% by D14, 28\\% and 60\\% by D21, for PSM and HSM, respectively). Multilayered surface of α-actin smooth muscle and Desmine-positive cells organized in bundles was seen as soon as D7, with no evidence of cell within the SIS. Myoblasts fusion was observed at D21. Pax3 and Pax7 expression was downregulated and MyoD expression upregulated, at D14.OEC proliferation was observed on HAM with both cell concentrations from D7 to D21. The cell metabolism activity was more important on matrix seeded by 10(6) cells/cm(2). With 0.5×10(6) OEC/cm(2), a single layer of pancytokeratin-positive cells was seen at D7, which became pluristratified by D14, while when 10(6) OEC/cm(2) were used, a pluristratified epithelial structure was seen as soon as D7. Proliferative cells (Proliferating Cell Nuclear Antigen staining) were mainly located at the basal layer.\nCONCLUSION: In this model, the optimal conditions of cell seeding in terms of cell concentration and culture duration were 0.5×10(6) myoblasts/cm(2) and 10(6) OEC/cm(2), and 7 days.},\n\tlanguage = {eng},\n\tnumber = {19-20},\n\tjournal = {Tissue Engineering. Part A},\n\tauthor = {Poghosyan, Tigran and Gaujoux, Sebastien and Vanneaux, Valerie and Bruneval, Patrick and Domet, Thomas and Lecourt, Severine and Jarraya, Mohamed and Sfeir, Rony and Larghero, Jerome and Cattan, Pierre},\n\tmonth = oct,\n\tyear = {2013},\n\tpmid = {23672649},\n\tpmcid = {PMC3761407},\n\tkeywords = {Animals, Cells, Cultured, Epithelial Cells, Esophagus, Humans, Myoblasts, Swine, Tissue Engineering, Tissue Scaffolds},\n\tpages = {2242--2252},\n}\n\n\n\n

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\n INTRODUCTION: Tissue engineering represents a promising approach for esophageal replacement, considering the complexity and drawbacks of conventional techniques. AIM: To create the components necessary to reconstruct in vitro or in vivo an esophageal wall, we analyzed the feasibility and the optimal conditions of human and pig skeletal myoblast (HSM and PSM) and porcine oral epithelial cell (OEC) culture on biologic scaffolds. MATERIALS AND METHODS: PSM and HSM were isolated from striated muscle and porcine OECs were extracted from oral mucosa biopsies. Myoblasts were seeded on an acellular scaffold issue from porcine small intestinal submucosa (SIS) and OEC on decellularized human amniotic membrane (HAM). Seeding conditions (cell concentrations [0.5×10(6) versus 10(6) cells/cm(2)] and culture periods [7, 14 and 21 days]), were analyzed using the methyl thiazoltetrazolium assay, quantitative PCR, flow cytometry, and immunohistochemistry. RESULTS: Phenotypic stability was observed after cellular expansion for PSM and HSM (85% and 97% CD56-positive cells, respectively), and OECs (90% AE1/AE3- positive cells). After PSM and HSM seeding, quantities of viable cells were similar whatever the initial cell concentration used and remained stable at all time points. During cell culture on SIS, a decrease of CD56-positive cells was observed (76% and 76% by D7, 56% and 70% by D14, 28% and 60% by D21, for PSM and HSM, respectively). Multilayered surface of α-actin smooth muscle and Desmine-positive cells organized in bundles was seen as soon as D7, with no evidence of cell within the SIS. Myoblasts fusion was observed at D21. Pax3 and Pax7 expression was downregulated and MyoD expression upregulated, at D14.OEC proliferation was observed on HAM with both cell concentrations from D7 to D21. The cell metabolism activity was more important on matrix seeded by 10(6) cells/cm(2). With 0.5×10(6) OEC/cm(2), a single layer of pancytokeratin-positive cells was seen at D7, which became pluristratified by D14, while when 10(6) OEC/cm(2) were used, a pluristratified epithelial structure was seen as soon as D7. Proliferative cells (Proliferating Cell Nuclear Antigen staining) were mainly located at the basal layer. CONCLUSION: In this model, the optimal conditions of cell seeding in terms of cell concentration and culture duration were 0.5×10(6) myoblasts/cm(2) and 10(6) OEC/cm(2), and 7 days.\n

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\n \n\n \n \n \n \n \n \n Postoperative lower esophageal dilation in children following the performance of Nissen fundoplication.\n \n \n \n \n\n\n \n Schneider, A.; Gottrand, F.; Sfeir, R.; Duhamel, A.; Bonnevalle, M.; Guimber, D.; and Michaud, L.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 22(5): 399–403. October 2012.\n \n\n\n\n
\n\n\n\n \n \n $\"Postoperative$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{schneider_postoperative_2012,\n\ttitle = {Postoperative lower esophageal dilation in children following the performance of {Nissen} fundoplication},\n\tvolume = {22},\n\tissn = {1439-359X},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/22773348/},\n\tdoi = {10.1055/s-0032-1315807},\n\tabstract = {OBJECTIVES: The purpose of this study is to study the frequency and factors associated with lower esophageal dilation (LED) after Nissen fundoplication.\nMETHODS: This retrospective monocentric study included 288 patients who had undergone Nissen fundoplication from 1998 to 2009. The frequency of children requiring LED was assessed. The clinical characteristics of the patients at the time of fundoplication, their symptoms, and outcomes were recorded. The population with LED (group 1) was compared with the population without LED (group 2) to identify factors associated with postfundoplication LED using multivariate analysis.\nRESULTS: LED was required by 70 patients (24\\%) because of postoperative dysphagia, and 45/70 were dilated within the first 6 months. The mean age at dilation was 72 months (standard deviation [SD] 65), with an average post-Nissen delay of 9 months (SD 13). Surgical revision was required by 11 patients because of LED failure (n = 10) or postdilation perforation (n = 1). Patients who required post-Nissen dilation were significantly more frequently fed orally than those in group 2 and had more postoperative complications (dumping syndrome, surgical revision).\nCONCLUSIONS: A significant frequency of postfundoplication LED was observed in this pediatric population. Dilation was associated in children with preoperative feeding or postoperative complications (dumping syndrome, surgical revision).},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Schneider, Anne and Gottrand, Frédéric and Sfeir, Rony and Duhamel, Alain and Bonnevalle, Michel and Guimber, Dominique and Michaud, Laurent},\n\tmonth = oct,\n\tyear = {2012},\n\tpmid = {22773348},\n\tkeywords = {Adolescent, Adult, Child, Child, Preschool, Deglutition Disorders, Dilatation, Dumping Syndrome, Enteral Nutrition, Female, France, Fundoplication, Humans, Infant, Male, Multivariate Analysis, Proportional Hazards Models, Reoperation, Retrospective Studies, Risk Factors, Treatment Outcome},\n\tpages = {399--403},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n EFTUD2 haploinsufficiency leads to syndromic oesophageal atresia.\n \n \n \n \n\n\n \n Gordon, C. T.; Petit, F.; Oufadem, M.; Decaestecker, C.; Jourdain, A.; Andrieux, J.; Malan, V.; Alessandri, J.; Baujat, G.; Baumann, C.; Boute-Benejean, O.; Caumes, R.; Delobel, B.; Dieterich, K.; Gaillard, D.; Gonzales, M.; Lacombe, D.; Escande, F.; Manouvrier-Hanu, S.; Marlin, S.; Mathieu-Dramard, M.; Mehta, S. G.; Simonic, I.; Munnich, A.; Vekemans, M.; Porchet, N.; de Pontual, L.; Sarnacki, S.; Attie-Bitach, T.; Lyonnet, S.; Holder-Espinasse, M.; and Amiel, J.\n\n\n \n\n\n\n Journal of Medical Genetics, 49(12): 737–746. December 2012.\n \n\n\n\n
\n\n\n\n \n \n $\"EFTUD2$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gordon_eftud2_2012,\n\ttitle = {{EFTUD2} haploinsufficiency leads to syndromic oesophageal atresia},\n\tvolume = {49},\n\tissn = {1468-6244},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23188108/},\n\tdoi = {10.1136/jmedgenet-2012-101173},\n\tabstract = {BACKGROUND: Oesophageal atresia (OA) and mandibulofacial dysostosis (MFD) are two congenital malformations for which the molecular bases of syndromic forms are being identified at a rapid rate. In particular, the EFTUD2 gene encoding a protein of the spliceosome complex has been found mutated in patients with MFD and microcephaly (MIM610536). Until now, no syndrome featuring both MFD and OA has been clearly delineated.\nRESULTS: We report on 10 cases presenting with MFD, eight of whom had OA, either due to de novo 17q21.31 deletions encompassing EFTUD2 and neighbouring genes or de novo heterozygous EFTUD2 loss-of-function mutations. No EFTUD2 deletions or mutations were found in a series of patients with isolated OA or isolated oculoauriculovertebral spectrum (OAVS).\nCONCLUSIONS: These data exclude a contiguous gene syndrome for the association of MFD and OA, broaden the spectrum of clinical features ascribed to EFTUD2 haploinsufficiency, define a novel syndromic OA entity, and emphasise the necessity of mRNA maturation through the spliceosome complex for global growth and within specific regions of the embryo during development. Importantly, the majority of patients reported here with EFTUD2 lesions were previously diagnosed with Feingold or CHARGE syndromes or presented with OAVS plus OA, highlighting the variability of expression and the wide range of differential diagnoses.},\n\tlanguage = {eng},\n\tnumber = {12},\n\tjournal = {Journal of Medical Genetics},\n\tauthor = {Gordon, Christopher T. and Petit, Florence and Oufadem, Myriam and Decaestecker, Charles and Jourdain, Anne-Sophie and Andrieux, Joris and Malan, Valérie and Alessandri, Jean-Luc and Baujat, Geneviève and Baumann, Clarisse and Boute-Benejean, Odile and Caumes, Roseline and Delobel, Bruno and Dieterich, Klaus and Gaillard, Dominique and Gonzales, Marie and Lacombe, Didier and Escande, Fabienne and Manouvrier-Hanu, Sylvie and Marlin, Sandrine and Mathieu-Dramard, Michèle and Mehta, Sarju G. and Simonic, Ingrid and Munnich, Arnold and Vekemans, Michel and Porchet, Nicole and de Pontual, Loïc and Sarnacki, Sabine and Attie-Bitach, Tania and Lyonnet, Stanislas and Holder-Espinasse, Muriel and Amiel, Jeanne},\n\tmonth = dec,\n\tyear = {2012},\n\tpmid = {23188108},\n\tkeywords = {Adolescent, Child, Child, Preschool, Chromosome Deletion, Chromosomes, Human, Pair 17, Comparative Genomic Hybridization, Esophageal Atresia, Facies, Female, Haploinsufficiency, Humans, Infant, Male, Peptide Elongation Factors, Phenotype, Ribonucleoprotein, U5 Small Nuclear, Syndrome},\n\tpages = {737--746},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n A simple technique of oblique anastomosis can prevent stricture formation in primary repair of esophageal atresia.\n \n \n \n\n\n \n Catalano, P.; Di Pace, M. R.; Caruso, A. M.; Salerno, S.; Cimador, M.; and De Grazia, E.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 47(9): 1767–1771. September 2012.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{catalano_simple_2012,\n\ttitle = {A simple technique of oblique anastomosis can prevent stricture formation in primary repair of esophageal atresia},\n\tvolume = {47},\n\tissn = {1531-5037},\n\tdoi = {10.1016/j.jpedsurg.2012.04.021},\n\tabstract = {BACKGROUND: Anastomotic stricture is an important problem after esophageal atresia (EA) repair. This study evaluates a technique of oblique esophageal anastomosis without use of a flap in order to prevent stricture formation.\nMETHODS: Medical records of 16 patients (14 with EA type III and 2 with EA type IV Ladd-Gross classification) who underwent primary repair of EA at birth without anastomotic tension were reviewed, evaluating long-term follow-up results. All patients were studied with esophageal contrast study, pH-multichannel intraluminal impedance, and endoscopy. The incidence of complications and their management were analysed.\nRESULTS: Contrast esophagogram and esophagoscopy always showed regular patency of the suture line.\nCONCLUSIONS: Our technique of oblique anastomosis is simple, safe, and effective in preventing stricture formation even in the long-term follow-up.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Catalano, Pieralba and Di Pace, Maria Rita and Caruso, Anna Maria and Salerno, Sergio and Cimador, Marcello and De Grazia, Enrico},\n\tmonth = sep,\n\tyear = {2012},\n\tpmid = {22974622},\n\tkeywords = {Anastomosis, Surgical, Esophageal Atresia, Esophageal Stenosis, Esophagoplasty, Female, Follow-Up Studies, Humans, Incidence, Infant, Newborn, Male, Postoperative Complications, Retrospective Studies, Treatment Outcome},\n\tpages = {1767--1771},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Peroral endoscopic myotomy (POEM) in a 3-year-old girl with severe growth retardation, achalasia, and Down syndrome.\n \n \n \n\n\n \n Maselli, R.; Inoue, H.; Misawa, M.; Ikeda, H.; Hosoya, T.; Onimaru, M.; Yoshida, A.; Eleftheriadis, N.; Suzuki, K.; and Kudo, S.\n\n\n \n\n\n\n Endoscopy, 44 Suppl 2 UCTN: E285–287. 2012.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{maselli_peroral_2012,\n\ttitle = {Peroral endoscopic myotomy ({POEM}) in a 3-year-old girl with severe growth retardation, achalasia, and {Down} syndrome},\n\tvolume = {44 Suppl 2 UCTN},\n\tissn = {1438-8812},\n\tdoi = {10.1055/s-0032-1309924},\n\tlanguage = {eng},\n\tjournal = {Endoscopy},\n\tauthor = {Maselli, R. and Inoue, H. and Misawa, M. and Ikeda, H. and Hosoya, T. and Onimaru, M. and Yoshida, A. and Eleftheriadis, N. and Suzuki, K. and Kudo, S.},\n\tyear = {2012},\n\tpmid = {22933258},\n\tkeywords = {Child, Preschool, Down Syndrome, Esophageal Achalasia, Esophageal Sphincter, Lower, Female, Growth Disorders, Humans, Natural Orifice Endoscopic Surgery},\n\tpages = {E285--287},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Surgical advances in the fetus and neonate: esophageal atresia.\n \n \n \n\n\n \n Kunisaki, S. M.; and Foker, J. E.\n\n\n \n\n\n\n Clinics in Perinatology, 39(2): 349–361. June 2012.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{kunisaki_surgical_2012,\n\ttitle = {Surgical advances in the fetus and neonate: esophageal atresia},\n\tvolume = {39},\n\tissn = {1557-9840},\n\tshorttitle = {Surgical advances in the fetus and neonate},\n\tdoi = {10.1016/j.clp.2012.04.007},\n\tabstract = {This article focuses on selected topics in the diagnosis and management of patients with esophageal atresia (EA) with or without tracheoesophageal fistula. The current status of prenatal diagnosis and recent advances in surgical techniques, including thoracoscopic repair for short-gap EA and tension-induced esophageal growth for long-gap EA, are reviewed. Although no consensus exists among pediatric surgeons regarding the role of these procedures in the treatment of EA, one can reasonably expect that, as they evolve, their application will become more widespread in this challenging patient population.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Clinics in Perinatology},\n\tauthor = {Kunisaki, Shaun M. and Foker, John E.},\n\tmonth = jun,\n\tyear = {2012},\n\tpmid = {22682384},\n\tkeywords = {Child, Digestive System Surgical Procedures, Esophageal Atresia, Female, Fetus, Humans, Infant, Newborn, Male, Thoracoscopy, Tracheoesophageal Fistula, Ultrasonography, Prenatal},\n\tpages = {349--361},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Nine new twin pairs with esophageal atresia: a review of the literature and performance of a twin study of the disorder.\n \n \n \n\n\n \n Schulz, A. C.; Bartels, E.; Stressig, R.; Ritgen, J.; Schmiedeke, E.; Mattheisen, M.; Draaken, M.; Ludwig, M.; Bagci, S.; Müller, A.; Gembruch, U.; Geipel, A.; Berg, C.; Heydweiller, A.; Bachour, H.; Schumacher, J.; Bartmann, P.; Nöthen, M. M.; and Reutter, H.\n\n\n \n\n\n\n Birth Defects Research. Part A, Clinical and Molecular Teratology, 94(3): 182–186. March 2012.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{schulz_nine_2012,\n\ttitle = {Nine new twin pairs with esophageal atresia: a review of the literature and performance of a twin study of the disorder},\n\tvolume = {94},\n\tissn = {1542-0760},\n\tshorttitle = {Nine new twin pairs with esophageal atresia},\n\tdoi = {10.1002/bdra.22879},\n\tabstract = {BACKGROUND: Isolated esophageal atresia (EA) is a rare congenital malformation whose etiology remains largely unknown. Nine twin pairs with EA were identified from our clinical service, prompting the performance of a systematic review of the literature and the first reported twin study of isolated EA.\nMETHODS: A total of 330 twin pairs with EA were identified from the literature. The zygosity, concordance, and malformation (isolated vs. nonisolated) status of all 339 twin pairs were evaluated. A total of 72 twin pairs (4 of 9 / 68 of 330) fulfilled the criteria for inclusion in a classic twin study of isolated EA.\nRESULTS: The pairwise concordance rates were 50\\% (95\\% confidence interval [CI], 34-66\\%) for monozygous (MZ) twin pairs and 26\\% (95\\% CI, 15-42\\%) for dizygous (DZ) twin pairs (p = 0.033). The probandwise concordance rates were 67\\% (95\\% CI, 53-78\\%) for MZ twin pairs and 42\\% (95\\% CI, 29-56\\%) for DZ twin pairs (p = 0.011). The MZ/DZ ratios were 1.9 for pairwise analysis and 1.6 for probandwise analysis. The familial risk ratios for MZ and DZ twin pairs were 1700 and 900, respectively.\nCONCLUSION: The observation of higher concordance rates for MZ compared to DZ twin pairs indicates that genetic factors contribute to isolated EA.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Birth Defects Research. Part A, Clinical and Molecular Teratology},\n\tauthor = {Schulz, Anna Carina and Bartels, Enrika and Stressig, Rüdiger and Ritgen, Jochen and Schmiedeke, Eberhard and Mattheisen, Manuel and Draaken, Markus and Ludwig, Michael and Bagci, Soyhan and Müller, Andreas and Gembruch, Ulrich and Geipel, Annegret and Berg, Christoph and Heydweiller, Andreas and Bachour, Haitham and Schumacher, Johannes and Bartmann, Peter and Nöthen, Markus M. and Reutter, Heiko},\n\tmonth = mar,\n\tyear = {2012},\n\tpmid = {22287212},\n\tkeywords = {Diseases in Twins, Esophageal Atresia, Female, Genetic Predisposition to Disease, Humans, Male, Twins, Dizygotic, Twins, Monozygotic},\n\tpages = {182--186},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n Eosinophilic esophagitis after esophageal atresia: is there an association? Case presentation and literature review.\n \n \n \n\n\n \n Gorter, R. R.; Heij, H. A.; van der Voorn, J. P.; and Kneepkens, C. M. F.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 47(6): e9–13. June 2012.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gorter_eosinophilic_2012,\n\ttitle = {Eosinophilic esophagitis after esophageal atresia: is there an association? {Case} presentation and literature review},\n\tvolume = {47},\n\tissn = {1531-5037},\n\tshorttitle = {Eosinophilic esophagitis after esophageal atresia},\n\tdoi = {10.1016/j.jpedsurg.2012.01.079},\n\tabstract = {Eosinophilic esophagitis (EoE) is a relatively new condition resulting in dysphagia or symptoms resembling gastroesophageal reflux disease, symptoms that also are common in patients with a history of esophageal atresia. We present 2 patients with persistent dysphagia after repair of esophageal atresia that was caused by EoE. Although the exact etiology and pathogenesis of EoE remain unclear, it is now generally accepted that it is the result of a T-helper cell 2-type immune response with a crucial role for the eosinophil-specific chemotaxis factor eotaxin 3 and eosinophils. Because there are genetic similarities between esophageal atresia and EoE, we speculate that patients with esophageal atresia are at increased risk for developing EoE.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Gorter, Ramon R. and Heij, Hugo A. and van der Voorn, J. Patrick and Kneepkens, C. M. Frank},\n\tmonth = jun,\n\tyear = {2012},\n\tpmid = {22703825},\n\tkeywords = {Abnormalities, Multiple, Anal Canal, Anti-Ulcer Agents, Barrett Esophagus, Chemokine CCL26, Chemokines, CC, Child, Combined Modality Therapy, Deglutition Disorders, Disease Susceptibility, Eosinophilia, Esophageal Atresia, Esophagitis, Esophagus, Female, Follow-Up Studies, Food Hypersensitivity, Forkhead Transcription Factors, Fundoplication, Gastroesophageal Reflux, Gene Deletion, Heart Defects, Congenital, Hernia, Hiatal, Humans, Infant, Newborn, Kidney, Limb Deformities, Congenital, Male, Postoperative Complications, Spine, Th2 Cells, Trachea, Tracheoesophageal Fistula},\n\tpages = {e9--13},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Colonic conduit for esophageal replacement: long-term endoscopic and histopathologic changes in colonic mucosa.\n \n \n \n\n\n \n Elshafei, H.; Elshafei, E.; ElDebeiky, M.; Hegazy, N.; Zaki, A.; and Abdel Hay, S.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 47(9): 1658–1661. September 2012.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{elshafei_colonic_2012,\n\ttitle = {Colonic conduit for esophageal replacement: long-term endoscopic and histopathologic changes in colonic mucosa},\n\tvolume = {47},\n\tissn = {1531-5037},\n\tshorttitle = {Colonic conduit for esophageal replacement},\n\tdoi = {10.1016/j.jpedsurg.2012.04.002},\n\tabstract = {BACKGROUND: Long-term follow-up has substantiated the colon as a durable and highly acceptable esophageal substitute. Exposure of colonic conduit to gastric acid may lead to histopathologic changes in the form of chronic inflammation.\nMATERIALS/METHODS: Thirty children with esophageal replacement were studied from 2 to 12 years (mean, 5.20 years) postoperatively. All cases underwent upper gastrointestinal tract endoscopy to evaluate the gross appearance of colonic conduit mucosa, and punch biopsies were taken from upper and lower junctions of the conduit. All biopsies were submitted to histopathologic examination.\nRESULTS: Endoscopic findings were comparable with normal regarding the gross appearance of colonic mucosa in both upper and lower junctions (25 cases/83.3\\%). Some abnormalities were seen including cervical anastomosis stricture (2 cases/6.7\\%), redundancy (3 cases/10\\%), mucosal ulcer in the lower residual esophagus (1 case/3.3\\%), and hyperemia (3 cases/10\\%). Pathologic changes were minimal regarding the change in position of the colon to a thoracic organ during follow-up. Most of the cases were normal (22 cases/73.3\\%). Seven cases (23.4\\%) showed mild chronic nonspecific inflammation of the colonic mucosa, whereas only 1 case (3.3\\%) showed mildly active inflammation of colonic mucosa.\nCONCLUSION: The use of the colon for esophageal replacement showed that no significant pathologic changes affecting its function as a conduit because its mucosa showed no significant change in response to gastric acid reflux in long-term follow-up and can be further protected by an antireflux procedure.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Elshafei, Hossam and Elshafei, Ehab and ElDebeiky, Mohamed and Hegazy, Nedal and Zaki, Ahmed and Abdel Hay, Sameh},\n\tmonth = sep,\n\tyear = {2012},\n\tpmid = {22974602},\n\tkeywords = {Adolescent, Anastomosis, Surgical, Biopsy, Child, Child, Preschool, Colon, Esophageal Atresia, Esophagoscopy, Esophagus, Female, Follow-Up Studies, Gastroesophageal Reflux, Humans, Infant, Infant, Newborn, Intestinal Mucosa, Male, Postoperative Complications, Stomach, Treatment Outcome},\n\tpages = {1658--1661},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n Current knowledge on esophageal atresia.\n \n \n \n\n\n \n Pinheiro, P. F. M.; Simões e Silva, A. C.; and Pereira, R. M.\n\n\n \n\n\n\n World Journal of Gastroenterology, 18(28): 3662–3672. July 2012.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{pinheiro_current_2012,\n\ttitle = {Current knowledge on esophageal atresia},\n\tvolume = {18},\n\tissn = {2219-2840},\n\tdoi = {10.3748/wjg.v18.i28.3662},\n\tabstract = {Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is the most common congenital anomaly of the esophagus. The improvement of survival observed over the previous two decades is multifactorial and largely attributable to advances in neonatal intensive care, neonatal anesthesia, ventilatory and nutritional support, antibiotics, early surgical intervention, surgical materials and techniques. Indeed, mortality is currently limited to those cases with coexisting severe life-threatening anomalies. The diagnosis of EA is most commonly made during the first 24 h of life but may occur either antenatally or may be delayed. The primary surgical correction for EA and TEF is the best option in the absence of severe malformations. There is no ideal replacement for the esophagus and the optimal surgical treatment for patients with long-gap EA is still controversial. The primary complications during the postoperative period are leak and stenosis of the anastomosis, gastro-esophageal reflux, esophageal dysmotility, fistula recurrence, respiratory disorders and deformities of the thoracic wall. Data regarding long-term outcomes and follow-ups are limited for patients following EA/TEF repair. The determination of the risk factors for the complicated evolution following EA/TEF repair may positively impact long-term prognoses. Much remains to be studied regarding this condition. This manuscript provides a literature review of the current knowledge regarding EA.},\n\tlanguage = {eng},\n\tnumber = {28},\n\tjournal = {World Journal of Gastroenterology},\n\tauthor = {Pinheiro, Paulo Fernando Martins and Simões e Silva, Ana Cristina and Pereira, Regina Maria},\n\tmonth = jul,\n\tyear = {2012},\n\tpmid = {22851858},\n\tpmcid = {PMC3406418},\n\tkeywords = {Adult, Anastomosis, Surgical, Child, Child, Preschool, Esophageal Atresia, Esophageal Stenosis, Esophageal atresia, Esophageal stenosis, Esophagus, Gastro-esophageal reflux, Gastroenterology, Gastroesophageal Reflux, Humans, Infant, Infant, Newborn, Long-gap, Prognosis, Risk Factors, Surgical Procedures, Operative, Time Factors, Tracheoesophageal Fistula, Tracheoesophageal fistula, Treatment Outcome},\n\tpages = {3662--3672},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Long-term outcome of children with oesophageal atresia type III.\n \n \n \n \n\n\n \n Legrand, C.; Michaud, L.; Salleron, J.; Neut, D.; Sfeir, R.; Thumerelle, C.; Bonnevalle, M.; Turck, D.; and Gottrand, F.\n\n\n \n\n\n\n Archives of Disease in Childhood, 97(9): 808–811. September 2012.\n \n\n\n\n
\n\n\n\n \n \n $\"Long-term$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{legrand_long-term_2012,\n\ttitle = {Long-term outcome of children with oesophageal atresia type {III}},\n\tvolume = {97},\n\tissn = {1468-2044},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/22753768/},\n\tdoi = {10.1136/archdischild-2012-301730},\n\tabstract = {OBJECTIVE: The aim of this study was to evaluate the outcome of patients with oesophageal atresia type III (EA), focusing on the presence of late sequelae and quality of life.\nMETHODS: This was a retrospective case ascertainment followed by clinical assessment of patients. The study parameters included the patients' demographic characteristics, associated abnormalities, presence of gastro-oesophageal reflux disease (GERD) and digestive or respiratory symptoms, results of a clinical examination to evaluate nutritional status, spirometry results and quality of life assessed using the PedsQL 4.0 questionnaire.\nRESULTS: Of 81 patients with EA type III treated in our institution over a 10-year period, 57 (mean age 13.3 (SE 2.8) years) participated in the study. 39\\% of the patients underwent fundoplication and 46\\% presented with anastomotic stenosis requiring dilation. 75\\% of patients had normal nutritional status (16\\% were obese, 9\\% were undernourished). Only 19\\% of participants had no digestive symptoms; 61\\% had dysphagia and 35\\% had symptoms of GERD at the last follow-up. The main respiratory symptoms were chronic cough (19\\%) and dyspnoea on exertion (37\\%). Only 37\\% of patients had no respiratory symptoms. Spirometry showed that 50\\% of patients had proximal obstruction and/or pulmonary distension, and 11\\% had restriction syndrome. Their quality of life was good but was lower than in healthy controls (80 vs 84, p{\\textless}0.05) and lower in patients born prematurely, with symptoms of GERD and with a barky cough.\nCONCLUSION: The high frequency of late sequelae in EA type III justifies regular and multidisciplinary follow-up through to adulthood.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Archives of Disease in Childhood},\n\tauthor = {Legrand, Céline and Michaud, Laurent and Salleron, Julia and Neut, Dorothée and Sfeir, Rony and Thumerelle, Caroline and Bonnevalle, Michel and Turck, Dominique and Gottrand, Frederic},\n\tmonth = sep,\n\tyear = {2012},\n\tpmid = {22753768},\n\tkeywords = {Adolescent, Child, Deglutition Disorders, Esophageal Atresia, Female, Gastroesophageal Reflux, Humans, Male, Nutritional Status, Prognosis, Quality of Life, Respiration Disorders, Retrospective Studies},\n\tpages = {808--811},\n}\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Percutaneous gastrojejunostomy in children: efficacy and safety.\n \n \n \n \n\n\n \n Michaud, L.; Coopman, S.; Guimber, D.; Sfeir, R.; Turck, D.; and Gottrand, F.\n\n\n \n\n\n\n Archives of Disease in Childhood, 97(8): 733–734. August 2012.\n \n\n\n\n
\n\n\n\n \n \n $\"Percutaneous$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{michaud_percutaneous_2012,\n\ttitle = {Percutaneous gastrojejunostomy in children: efficacy and safety},\n\tvolume = {97},\n\tissn = {1468-2044},\n\tshorttitle = {Percutaneous gastrojejunostomy in children},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/22504731/},\n\tdoi = {10.1136/archdischild-2011-300653},\n\tabstract = {Transgastric jejunal intubation via gastrostomy (GJ) can be indicated when enteral nutrition via gastrostomy is not possible. Between 2001 and 2008, the authors prospectively assessed the outcomes in 29 patients (median age, 10 months) after GJ. Indications for jejunal feeding were severe gastro-oesophageal reflux (n=27) and intestinal dysmotility (n=2). The GJ was successfully placed in 27/29 patients. Complications were: 31 tube dislodgements, 16 obstructions, 7 leakages around the tube, 6 internal balloon ruptures and 1 intussusception. The median lifetime of the tube was 3 months. 9/27 patients died during the study period, 11 patients required surgery, 2 required parenteral nutrition, gastric feeding became tolerated in 3 and the gastrojejunal feeding tube was kept in place in the remaining 2. A transgastric jejunal feeding tube may constitute a transitory alternative to antireflux surgery or prolonged parenteral nutrition. However, the high frequency of complications and tube replacement limits its use.},\n\tlanguage = {eng},\n\tnumber = {8},\n\tjournal = {Archives of Disease in Childhood},\n\tauthor = {Michaud, Laurent and Coopman, Stéphanie and Guimber, Dominique and Sfeir, Rony and Turck, Dominique and Gottrand, Frédéric},\n\tmonth = aug,\n\tyear = {2012},\n\tpmid = {22504731},\n\tkeywords = {Adolescent, Child, Child, Preschool, Enteral Nutrition, Gastric Bypass, Gastroesophageal Reflux, Humans, Infant, Intestinal Diseases, Jejunostomy, Nutritional Status, Prospective Studies, Risk Factors, Treatment Outcome, Young Adult},\n\tpages = {733--734},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n One-step percutaneous gastrojejunostomy in early infancy.\n \n \n \n \n\n\n \n Michaud, L.; Robert-Dehault, A.; Coopman, S.; Guimber, D.; Turck, D.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 54(6): 820–821. June 2012.\n \n\n\n\n
\n\n\n\n \n \n $\"One-step$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{michaud_one-step_2012,\n\ttitle = {One-step percutaneous gastrojejunostomy in early infancy},\n\tvolume = {54},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/22331018/},\n\tdoi = {10.1097/MPG.0b013e31824d970f},\n\tabstract = {In certain conditions that obviate the use of gastric feedings, the insertion of a jejunal feeding tube via gastrostomy constitutes an alternative to jejunostomy but requires a preexisting gastrostomy. Our aim was to assess a new technique of 1-step gastrojejunal tube insertion through a de novo gastrostomy. A total of 3 infants between 3 and 7 months old and weighing between 4.1 and 5.4 kg had a gastrojejunal feeding tube inserted using a 16-CH French introducer percutaneous endoscopic gastrostomy kit and a transgastric-jejunal feeding tube. No technical difficulties occurred and the gastrojejunal feeding tube was placed successfully in the 3 patients, the total procedure lasting 15 to 20 minutes. Enteral feeding was started within 4 to 6 hours of the procedure. Neither immediate ({\\textless}24 hours) nor late complications related to the gastrojejunostomy occurred. Nissen fundoplication was performed in 2 of our patients at 12 and 15 months of age, respectively. The gastrojejunostomy tube was still in place in the third patient at age 15 months. Our first experience suggests that 1-step endoscopic placement of a transgastric-jejunal feeding tube without a preexisting gastrostomy tract is feasible in young and low-weight infants.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Michaud, Laurent and Robert-Dehault, Amélie and Coopman, Stéphanie and Guimber, Dominique and Turck, Dominique and Gottrand, Frédéric},\n\tmonth = jun,\n\tyear = {2012},\n\tpmid = {22331018},\n\tkeywords = {Body Weight, Endoscopy, Gastrointestinal, Enteral Nutrition, Fundoplication, Gastric Bypass, Gastrostomy, Humans, Infant, Intubation, Gastrointestinal, Jejunostomy, Jejunum, Outcome Assessment, Health Care},\n\tpages = {820--821},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Functional gastrointestinal disorders induced by esophageal atresia surgery: is it valid in humans?.\n \n \n \n \n\n\n \n Halac, U.; Revillion, M.; Michaud, L.; Gottrand, F.; and Faure, C.\n\n\n \n\n\n\n Journal of Neurogastroenterology and Motility, 18(4): 406–411. October 2012.\n \n\n\n\n
\n\n\n\n \n \n $\"Functional$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{halac_functional_2012,\n\ttitle = {Functional gastrointestinal disorders induced by esophageal atresia surgery: is it valid in humans?},\n\tvolume = {18},\n\tissn = {2093-0887},\n\tshorttitle = {Functional gastrointestinal disorders induced by esophageal atresia surgery},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23106001/},\n\tdoi = {10.5056/jnm.2012.18.4.406},\n\tabstract = {BACKGROUND/AIMS: Functional gastrointestinal disorders (FGID) affect 15\\%-20\\% of the general pediatric and adult population. Animal models suggest that a neonatal stress such as invasive procedures and maternal separation could be responsible for visceral hypersensitivity and FGID. We tested the hypothesis that congenital esophageal atresia (EA), a condition corrected during the neonatal period and associated with multiple stresses, is a clinically significant risk factor for the development of FGID later in life. We postulated that, to be clinically significant, the effect of neonatal stress on the incidence of FGID should be as strong as that of enteric infections in the development of irritable bowel syndrome in children.\nMETHODS: Subjects with EA and healthy controls were enrolled in this multicenter cohort study. Gastrointestinal symptoms were assessed by a questionnaire and FGID was diagnosed using the Rome III criteria.\nRESULTS: Fifty-three children (25 girls; median age, 12 years) with EA were compared to 72 age- and sex-matched controls. Although 11 children with EA (21\\%) had a FGID diagnosis versus 8 controls (11\\%), this difference was not significant (χ(2) = 2.20, P {\\textgreater} 0.05). In subjects with EA, the presence of associated malformations, the occurrence of complications during the first month, and the length of hospital stay {\\textgreater} 30 days did not influence the incidence of FGID. Chronic abdominal pain was present in 38\\% of subjects with EA versus 25\\% of controls (P {\\textgreater} 0.05).\nCONCLUSIONS: Neonatal stress secondary to surgical correction of EA is not a clinically significant risk factor for the development of FGID in childhood.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Neurogastroenterology and Motility},\n\tauthor = {Halac, Ugur and Revillion, Marine and Michaud, Laurent and Gottrand, Frédéric and Faure, Christophe},\n\tmonth = oct,\n\tyear = {2012},\n\tpmid = {23106001},\n\tpmcid = {PMC3479254},\n\tkeywords = {Esophageal atresia, Irritable bowel syndrome, Life change events},\n\tpages = {406--411},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n A preliminary study of computer assisted evaluation of congenital tracheal stenosis: a new tool for surgical decision-making.\n \n \n \n \n\n\n \n Mimouni-Benabu, O.; Meister, L.; Giordano, J.; Fayoux, P.; Loundon, N.; Triglia, J. M.; and Nicollas, R.\n\n\n \n\n\n\n International Journal of Pediatric Otorhinolaryngology, 76(11): 1552–1557. November 2012.\n \n\n\n\n
\n\n\n\n \n \n $\"A$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{mimouni-benabu_preliminary_2012,\n\ttitle = {A preliminary study of computer assisted evaluation of congenital tracheal stenosis: a new tool for surgical decision-making},\n\tvolume = {76},\n\tissn = {1872-8464},\n\tshorttitle = {A preliminary study of computer assisted evaluation of congenital tracheal stenosis},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/22874591/},\n\tdoi = {10.1016/j.ijporl.2012.07.009},\n\tabstract = {OBJECTIVE: Congenital tracheal stenosis is a rare but severe condition with tracheal narrowing. There is no absolute correlation between luminal diameter and prognosis, and therapeutic decisions are difficult for intermediate cases. The aim of this study was to develop a dynamic model of the ventilatory consequences of congenital tracheal stenosis using computational fluid dynamics.\nMETHODS: In 8 children with congenital tracheal stenosis and 1 healthy child, 3-dimensional geometries of the trachea were constructed with computed tomography images and specialized software (ITK-SNAP). Airflow simulations were performed for each geometry using 2 physiologic inhalation flow rates under steady and laminar flow conditions. Flow velocity, static and total airway pressure, and pressure drop across the entire trachea were determined.\nRESULTS: In the patients with congenital tracheal stenosis, the pressure drop from the tracheal inlet to outlet, at flow rate 3L/min, ranged from 14 to 430Pa; the pressure drop at flow rate 7.3L/min ranged from 60 to 1825Pa. The pressure drop enabled a classification based on the severity of stenosis. The classification based on pressure drop was retrospectively consistent with the classification based on clinical data from the patients.\nCONCLUSIONS: Simulations with computational fluid dynamics may provide an objective method to evaluate the severity of the symptoms in patients with congenital tracheal stenosis and may help guide treatment.},\n\tlanguage = {eng},\n\tnumber = {11},\n\tjournal = {International Journal of Pediatric Otorhinolaryngology},\n\tauthor = {Mimouni-Benabu, Olivia and Meister, Lionel and Giordano, Jérôme and Fayoux, Pierre and Loundon, Natalie and Triglia, Jean Michel and Nicollas, Richard},\n\tmonth = nov,\n\tyear = {2012},\n\tpmid = {22874591},\n\tkeywords = {Computer Simulation, Decision Making, Humans, Hydrodynamics, Image Processing, Computer-Assisted, Infant, Infant, Newborn, Models, Biological, Pressure, Respiratory Mechanics, Retrospective Studies, Severity of Illness Index, Software, Tomography, X-Ray Computed, Trachea, Tracheal Stenosis},\n\tpages = {1552--1557},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n What is the incidence of Barrett's and gastric metaplasia in esophageal atresia/tracheoesophageal fistula (EA/TEF) patients?.\n \n \n \n\n\n \n Burjonrappa, S. C.; Youssef, S.; and St-Vil, D.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 21(1): 25–29. January 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{burjonrappa_what_2011,\n\ttitle = {What is the incidence of {Barrett}'s and gastric metaplasia in esophageal atresia/tracheoesophageal fistula ({EA}/{TEF}) patients?},\n\tvolume = {21},\n\tissn = {1439-359X},\n\tdoi = {10.1055/s-0030-1262861},\n\tabstract = {OBJECTIVE: Aim of the study was to document the incidence of gastric and intestinal metaplasia (Barrett's esophagus) in a closely followed group with EA/TEF, determine the efficacy of pH probe studies in diagnosing reflux and, moreover, to determine the lag period between the development of gastroesophageal reflux disease (GERD) and metaplasia.\nMATERIALS AND METHODS: Patients who underwent EA/TEF correction were followed up over an 18-year period (1990-2009) with regular pH probe and endoscopy investigations. Biopsies were performed at 3 year intervals to evaluate for metaplastic changes in the esophageal epithelium. The interval between esophageal atresia correction and the development of erosive esophagitis, gastric metaplasia and Barrett's esophagus was determined. The development of complicated GERD was statistically correlated to age at detection.\nRESULTS: 51 patients (28 male) underwent EA/TEF correction during the study period. The ages of the children followed up ranged from 7 months to 19 years. There were 5 Type A, 44 Type C and 2 Type D fistulas. 37 patients (5 Type A, 31 Type C, 1 Type D) had documented reflux and 14 did not. 17 (46\\%) of the patients with reflux underwent an anti-reflux operation. 4 of the 17 underwent 2 or more anti-reflux procedures. 21 patients had pH probe studies positive for reflux, 3 had negative pH probe studies after an anti-reflux operation. 18 of the 37 patients with reflux (about 50\\%) needed esophageal dilatation for either anastamotic or non-anastamotic strictures. Only 4/14 (28.5\\%) patients without reflux underwent dilatations and only in their first year of life (p=NS). 15 patients had mucosal abnormalities in endoscopic biopsies. 8 patients had gastric metaplasia and 1 patient had Barrett's esophagus. The mean age in the group with metaplasia (gastric and intestinal) was 13 years, which was significantly different from the mean age of the group (5.2 years) without mucosal changes (p{\\textless}0.001). 2 patients with normal pH probe studies had metaplasia on biopsies.\nCONCLUSION: Metaplasia arises in about 15\\% of patients with EA/TEF. The lag time to developing metaplasia from the time of initial surgical correction is about 10 years. Endoscopy and biopsies are the best way of detecting mucosal changes.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Burjonrappa, S. C. and Youssef, S. and St-Vil, D.},\n\tmonth = jan,\n\tyear = {2011},\n\tpmid = {20954108},\n\tkeywords = {Adolescent, Barrett Esophagus, Child, Child, Preschool, Esophageal Atresia, Esophagus, Female, Gastroesophageal Reflux, Humans, Incidence, Infant, Male, Metaplasia, Tracheoesophageal Fistula, Young Adult},\n\tpages = {25--29},\n}\n\n\n\n\n\n\n\n

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\n OBJECTIVE: Aim of the study was to document the incidence of gastric and intestinal metaplasia (Barrett's esophagus) in a closely followed group with EA/TEF, determine the efficacy of pH probe studies in diagnosing reflux and, moreover, to determine the lag period between the development of gastroesophageal reflux disease (GERD) and metaplasia. MATERIALS AND METHODS: Patients who underwent EA/TEF correction were followed up over an 18-year period (1990-2009) with regular pH probe and endoscopy investigations. Biopsies were performed at 3 year intervals to evaluate for metaplastic changes in the esophageal epithelium. The interval between esophageal atresia correction and the development of erosive esophagitis, gastric metaplasia and Barrett's esophagus was determined. The development of complicated GERD was statistically correlated to age at detection. RESULTS: 51 patients (28 male) underwent EA/TEF correction during the study period. The ages of the children followed up ranged from 7 months to 19 years. There were 5 Type A, 44 Type C and 2 Type D fistulas. 37 patients (5 Type A, 31 Type C, 1 Type D) had documented reflux and 14 did not. 17 (46%) of the patients with reflux underwent an anti-reflux operation. 4 of the 17 underwent 2 or more anti-reflux procedures. 21 patients had pH probe studies positive for reflux, 3 had negative pH probe studies after an anti-reflux operation. 18 of the 37 patients with reflux (about 50%) needed esophageal dilatation for either anastamotic or non-anastamotic strictures. Only 4/14 (28.5%) patients without reflux underwent dilatations and only in their first year of life (p=NS). 15 patients had mucosal abnormalities in endoscopic biopsies. 8 patients had gastric metaplasia and 1 patient had Barrett's esophagus. The mean age in the group with metaplasia (gastric and intestinal) was 13 years, which was significantly different from the mean age of the group (5.2 years) without mucosal changes (p\\textless0.001). 2 patients with normal pH probe studies had metaplasia on biopsies. CONCLUSION: Metaplasia arises in about 15% of patients with EA/TEF. The lag time to developing metaplasia from the time of initial surgical correction is about 10 years. Endoscopy and biopsies are the best way of detecting mucosal changes.\n

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\n \n\n \n \n \n \n \n \n Pseudostratified ciliated metaplasia of the distal esophagus diagnosed at adolescence.\n \n \n \n \n\n\n \n Schneider, A.; Maunoury, V.; Leteurtre, E.; Turck, D.; Gottrand, F.; and Michaud, L.\n\n\n \n\n\n\n Endoscopy, 43 Suppl 2 UCTN: E184. 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Pseudostratified$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{schneider_pseudostratified_2011,\n\ttitle = {Pseudostratified ciliated metaplasia of the distal esophagus diagnosed at adolescence},\n\tvolume = {43 Suppl 2 UCTN},\n\tissn = {1438-8812},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21557159/},\n\tdoi = {10.1055/s-0030-1256301},\n\tlanguage = {eng},\n\tjournal = {Endoscopy},\n\tauthor = {Schneider, A. and Maunoury, V. and Leteurtre, E. and Turck, D. and Gottrand, F. and Michaud, L.},\n\tyear = {2011},\n\tpmid = {21557159},\n\tkeywords = {Adolescent, Barrett Esophagus, Esophagus, Humans, Male, Metaplasia, Proton Pump Inhibitors},\n\tpages = {E184},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Another case of idiopathic megaesophagus in a girl with growth hormone deficiency.\n \n \n \n \n\n\n \n Djeddi, D.; Vanrenterghem, A.; Léké, A.; Boudailliez, B.; and Gottrand, F.\n\n\n \n\n\n\n Clinics and Research in Hepatology and Gastroenterology, 35(11): 768–770. November 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Another$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{djeddi_another_2011,\n\ttitle = {Another case of idiopathic megaesophagus in a girl with growth hormone deficiency},\n\tvolume = {35},\n\tissn = {2210-741X},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21778130/},\n\tdoi = {10.1016/j.clinre.2011.05.013},\n\tabstract = {BACKGROUND: Achalasia or idiopathic megaesophagus is rare in children, and an association with growth hormone (GH) deficiency has rarely been described.\nCASE REPORT: This report is of a girl treated with recombinant GH (rGH) for isolated GH deficiency who simultaneously presented with idiopathic megaesophagus.\nCONCLUSION: This case report highlights the fact that practitioners need to be aware of this possible morbid association.},\n\tlanguage = {eng},\n\tnumber = {11},\n\tjournal = {Clinics and Research in Hepatology and Gastroenterology},\n\tauthor = {Djeddi, D. and Vanrenterghem, A. and Léké, A. and Boudailliez, B. and Gottrand, F.},\n\tmonth = nov,\n\tyear = {2011},\n\tpmid = {21778130},\n\tkeywords = {Child, Esophageal Achalasia, Female, Human Growth Hormone, Humans},\n\tpages = {768--770},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Long-term follow-up of patients with esophageal replacement by reversed gastric tube.\n \n \n \n\n\n \n Gupta, L.; Bhatnagar, V.; Gupta, A. K.; and Kumar, R.\n\n\n \n\n\n\n European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie, 21(2): 88–93. March 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gupta_long-term_2011,\n\ttitle = {Long-term follow-up of patients with esophageal replacement by reversed gastric tube},\n\tvolume = {21},\n\tissn = {1439-359X},\n\tdoi = {10.1055/s-0030-1267240},\n\tabstract = {PURPOSE: Various surgical procedures are used for esophageal substitution in children. The purpose of this study was to evaluate the long-term outcome in children who underwent esophageal replacement by reversed gastric tube and to assess some aspects of the physiological function and behavior of the reversed gastric tube.\nMETHODS: This study was a retrospective and prospective review of 16 patients who had undergone reversed gastric tube esophagoplasty between March 1990 and March 2009. Indications for esophageal replacement included esophageal atresia with or without fistula (10) and caustic injury (6). There were 10 boys and 6 girls. Age at the time of this study varied from 1.7-20 years. The interval between operation and follow-up varied; it was more than 3 months in all cases, with an average of 8 months. Follow-up studies included clinical evaluation, anthropometry, barium study (to look for anastomotic leak, stricture, passage of contrast, ulcer, diverticulum, peristalsis and emptying), neoesophagus motility patterns by manometry, 24-h pH monitoring and radionuclide studies (to investigate esophageal transit and gastric emptying times and gastroesophageal reflux). Statistical analysis was carried out using STATA 9.0 and continuous variables were compared between the tests using the Wilcoxon rank sum test.\nRESULTS: Of the 16 children, 12 were between the 3 (rd) and 97 (th) percentiles for weight and 10 were between the 3 (rd) and 97 (th) percentiles for height for their respective age group. 14 were eating and swallowing normally. 2 patients had slight swallowing difficulties with lumpy foods but did not require dilatations. None of our patients had respiratory problems. The children with corrosive stricture were almost normal in growth and development compared to esophageal atresia patients. Barium swallow showed normal swallowing in all patients and did not show gastroesophageal reflux. Mass contractions were seen in two-thirds of the patients on manometry. 24-h pH monitoring showed that the intraluminal pH remained consistently low, even long after operative treatment. Scintigraphy and barium swallow showed almost similar results except that scintigraphy was much more sensitive in detecting reflux.\nCONCLUSION: Almost all children remained asymptomatic and led a normal life. The function of the neoesophagus was good and growth and nutrition in the majority of patients was satisfactory.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Fur Kinderchirurgie},\n\tauthor = {Gupta, L. and Bhatnagar, V. and Gupta, A. K. and Kumar, R.},\n\tmonth = mar,\n\tyear = {2011},\n\tpmid = {21058245},\n\tkeywords = {Burns, Chemical, Child, Preschool, Deglutition, Esophageal Atresia, Esophagoplasty, Esophagus, Female, Follow-Up Studies, Humans, Infant, Male, Prospective Studies, Recovery of Function, Retrospective Studies, Stomach, Time Factors, Treatment Outcome},\n\tpages = {88--93},\n}\n\n\n\n\n\n\n\n

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\n PURPOSE: Various surgical procedures are used for esophageal substitution in children. The purpose of this study was to evaluate the long-term outcome in children who underwent esophageal replacement by reversed gastric tube and to assess some aspects of the physiological function and behavior of the reversed gastric tube. METHODS: This study was a retrospective and prospective review of 16 patients who had undergone reversed gastric tube esophagoplasty between March 1990 and March 2009. Indications for esophageal replacement included esophageal atresia with or without fistula (10) and caustic injury (6). There were 10 boys and 6 girls. Age at the time of this study varied from 1.7-20 years. The interval between operation and follow-up varied; it was more than 3 months in all cases, with an average of 8 months. Follow-up studies included clinical evaluation, anthropometry, barium study (to look for anastomotic leak, stricture, passage of contrast, ulcer, diverticulum, peristalsis and emptying), neoesophagus motility patterns by manometry, 24-h pH monitoring and radionuclide studies (to investigate esophageal transit and gastric emptying times and gastroesophageal reflux). Statistical analysis was carried out using STATA 9.0 and continuous variables were compared between the tests using the Wilcoxon rank sum test. RESULTS: Of the 16 children, 12 were between the 3 (rd) and 97 (th) percentiles for weight and 10 were between the 3 (rd) and 97 (th) percentiles for height for their respective age group. 14 were eating and swallowing normally. 2 patients had slight swallowing difficulties with lumpy foods but did not require dilatations. None of our patients had respiratory problems. The children with corrosive stricture were almost normal in growth and development compared to esophageal atresia patients. Barium swallow showed normal swallowing in all patients and did not show gastroesophageal reflux. Mass contractions were seen in two-thirds of the patients on manometry. 24-h pH monitoring showed that the intraluminal pH remained consistently low, even long after operative treatment. Scintigraphy and barium swallow showed almost similar results except that scintigraphy was much more sensitive in detecting reflux. CONCLUSION: Almost all children remained asymptomatic and led a normal life. The function of the neoesophagus was good and growth and nutrition in the majority of patients was satisfactory.\n

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\n \n\n \n \n \n \n \n Long-term outcomes of adults with features of VACTERL association.\n \n \n \n\n\n \n Raam, M. S.; Pineda-Alvarez, D. E.; Hadley, D. W.; and Solomon, B. D.\n\n\n \n\n\n\n European Journal of Medical Genetics, 54(1): 34–41. 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{raam_long-term_2011,\n\ttitle = {Long-term outcomes of adults with features of {VACTERL} association},\n\tvolume = {54},\n\tissn = {1878-0849},\n\tdoi = {10.1016/j.ejmg.2010.09.007},\n\tabstract = {VACTERL association involves the presence of specific congenital, multi-organ malformations that tend to co-occur. Clinical and research efforts typically center on pediatric patients, and there is a scarcity of information in the literature regarding VACTERL-related issues and outcomes in adulthood. We describe here 11 adults with features of VACTERL association ascertained through our research study on the condition. In our cohort of adult patients, approximately 25\\% of medically significant malformations that are component features of VACTERL association, including 40\\% of vertebral, 50\\% of cardiac, and 50\\% of renal anomalies, were not identified during childhood. Additionally, medical sequelae of many of the primary malformations identified in infancy or early childhood persist or are first reported in adulthood. These sequelae can involve challenging medical and surgical management in adulthood. As most adults with VACTERL association are not specifically followed for VACTERL-related issues, a more uniform diagnostic work-up and a low threshold for investigation of medical sequelae of the primary disorder may enhance the quality of clinical management in these patients.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {European Journal of Medical Genetics},\n\tauthor = {Raam, Manu S. and Pineda-Alvarez, Daniel E. and Hadley, Donald W. and Solomon, Benjamin D.},\n\tyear = {2011},\n\tpmid = {20888933},\n\tpmcid = {PMC3033487},\n\tkeywords = {Abnormalities, Multiple, Adult, Anal Canal, Cohort Studies, Esophagus, Female, Heart Defects, Congenital, Humans, Kidney, Limb Deformities, Congenital, Male, Middle Aged, Spine, Time Factors, Trachea},\n\tpages = {34--41},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n Health-related quality of life in children with achalasia.\n \n \n \n\n\n \n Marlais, M.; Fishman, J. R.; Fell, J. M.; Rawat, D. J.; and Haddad, M. J.\n\n\n \n\n\n\n Journal of Paediatrics and Child Health, 47(1-2): 18–21. January 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{marlais_health-related_2011,\n\ttitle = {Health-related quality of life in children with achalasia},\n\tvolume = {47},\n\tissn = {1440-1754},\n\tdoi = {10.1111/j.1440-1754.2010.01884.x},\n\tabstract = {AIMS: To assess self-reported QoL in children with achalasia aged 5-18 and compare this with both disease and healthy control children in a prospective study.\nMETHODS: All children diagnosed with achalasia at one hospital were asked to participate in this study by completing the self-report module of the validated PedsQL™ generic QoL assessment. All children attending a tertiary paediatric gastroenterology clinic from February 2009 to May 2009 with chronic constipation or inflammatory bowel disease were asked to participate in this study as disease controls. The PedsQL™ considers physical, emotional, social and school domains and is scored from 0-100. Healthy children were also recruited from the same site. Groups were compared using Analysis of Variance with Tukey's post-hoc test.\nRESULTS: One hundred and sixty one children completed the assessment (90 (56\\%) male, mean age 11.3 yrs ± 3.4 years) including 17 children with achalasia, 44 with chronic constipation, 59 with inflammatory bowel disease and 41 healthy children. QoL was significantly lower in the achalasia group compared to both children with IBD (73 vs. 82, p = 0.035) and healthy children (73 vs. 84, p = 0.005), and was comparable to that of children with chronic constipation (73 vs. 74, p = 0.99).\nCONCLUSION: Children with achalasia report a significantly lower QoL compared to children with inflammatory bowel disease and healthy children.},\n\tlanguage = {eng},\n\tnumber = {1-2},\n\tjournal = {Journal of Paediatrics and Child Health},\n\tauthor = {Marlais, Matko and Fishman, Julia R. and Fell, John Me and Rawat, David J. and Haddad, Munther J.},\n\tmonth = jan,\n\tyear = {2011},\n\tpmid = {20973860},\n\tkeywords = {Adolescent, Case-Control Studies, Child, Constipation, Esophageal Achalasia, Female, Humans, Inflammatory Bowel Diseases, London, Male, Prospective Studies, Quality of Life, Sickness Impact Profile},\n\tpages = {18--21},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Evaluation of esophageal motility and reflux in children treated for esophageal atresia with the use of combined multichannel intraluminal impedance and pH monitoring.\n \n \n \n\n\n \n Di Pace, M. R.; Caruso, A. M.; Catalano, P.; Casuccio, A.; Cimador, M.; and De Grazia, E.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 46(3): 443–451. March 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{di_pace_evaluation_2011,\n\ttitle = {Evaluation of esophageal motility and reflux in children treated for esophageal atresia with the use of combined multichannel intraluminal impedance and {pH} monitoring},\n\tvolume = {46},\n\tissn = {1531-5037},\n\tdoi = {10.1016/j.jpedsurg.2010.08.012},\n\tabstract = {BACKGROUND: Gastroesophageal reflux (GER) and dysmotility are frequent in patients treated for esophageal atresia (EA). This aim of this study is to evaluate GER and dysmotility in young EA patients using pH-multichannel intraluminal impedance (pH-MII).\nMETHODS: Fifteen patients with a mean age of 7.5 years (group 1) have been studied and compared with 15 children without congenital malformation, submitted to pH-MII for suspected GER (group 2). These latter patients serve as a control group of healthy subjects. The following impedance reflux and motility parameters have been studied on 10 standardized swallows: number of reflux episodes, mean acid clearing time, median bolus clearing time, bolus presence time, total bolus transit time, segmental transit time, and total propagation velocity.\nRESULTS: In the group of EA patients, mean acid clearing time and median bolus clearing time were pathological. In the control group, all reflux parameters were normal. Patients with EA had significantly longer median bolus presence time at each measuring site, median total bolus transit time, and median segmental transit time and slower total propagation velocity (P {\\textless} .001).\nCONCLUSIONS: pH-multichannel intraluminal impedance evaluates both GER and motility patterns. Our report studies impedance parameters of esophageal motility in healthy children and in EA patients using only pH-MII.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Di Pace, Maria Rita and Caruso, Anna Maria and Catalano, Pieralba and Casuccio, Alessandra and Cimador, Marcello and De Grazia, Enrico},\n\tmonth = mar,\n\tyear = {2011},\n\tpmid = {21376190},\n\tkeywords = {Child, Child, Preschool, Deglutition, Electric Impedance, Esophageal Atresia, Esophageal Motility Disorders, Esophageal pH Monitoring, Esophagitis, Esophagoscopy, Esophagus, Female, Gastroesophageal Reflux, Humans, Male, Monitoring, Ambulatory, Peristalsis, Postoperative Complications, Rheology, Tracheoesophageal Fistula},\n\tpages = {443--451},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Repair of esophageal atresia with tracheoesophageal fistula via thoracotomy: a contemporary series.\n \n \n \n\n\n \n Burford, J. M.; Dassinger, M. S.; Copeland, D. R.; Keller, J. E.; and Smith, S. D.\n\n\n \n\n\n\n American Journal of Surgery, 202(2): 203–206. August 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{burford_repair_2011,\n\ttitle = {Repair of esophageal atresia with tracheoesophageal fistula via thoracotomy: a contemporary series},\n\tvolume = {202},\n\tissn = {1879-1883},\n\tshorttitle = {Repair of esophageal atresia with tracheoesophageal fistula via thoracotomy},\n\tdoi = {10.1016/j.amjsurg.2010.09.035},\n\tabstract = {BACKGROUND: A recent series detailing thoracoscopic repair of esophageal atresia with tracheoesophageal fistula (EA/TEF) reported lower complication rates compared with historic controls. This study provides a contemporary cohort of patients repaired via thoracotomy for comparison with the recent large multi-institutional thoracoscopic series.\nMETHODS: Records of patients with EA/TEF between 1993 and 2008 were reviewed. Attention was focused on demographics and complications including anastomotic leak, recurrent fistulae, stricture formation, and need for fundoplication.\nRESULTS: Seventy-two patients underwent repair of EA/TEF via thoracotomy. Complication rates in the current series compared with the thoracoscopic series were anastomotic leak, 2.7\\% versus 7.6\\%; recurrent fistulae, 2.7\\% versus 1.9\\%; stricture, 5.5\\% versus 3.8\\%; and need for fundoplication, 12\\% versus 24\\%. Differences in complication rates did not reach statistical significance. Two children in this cohort developed mild scoliosis attributed to congenital vertebral anomalies, neither of whom required intervention.\nCONCLUSIONS: Thoracoscopic repair of EA/TEF yielded complication rates similar to this contemporary series; however, trends toward increased anastomotic leaks and greater need for fundoplication were noted. No musculoskeletal sequelae were directly attributable to thoracotomy.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {American Journal of Surgery},\n\tauthor = {Burford, Jeffrey M. and Dassinger, Melvin S. and Copeland, Daniel R. and Keller, Jennifer E. and Smith, Samuel D.},\n\tmonth = aug,\n\tyear = {2011},\n\tpmid = {21810502},\n\tkeywords = {Abnormalities, Multiple, Esophageal Atresia, Female, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Thoracoscopy, Thoracotomy, Tracheoesophageal Fistula, Treatment Outcome},\n\tpages = {203--206},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Perioperative outcome of patients with esophageal atresia and tracheo-esophageal fistula undergoing open versus thoracoscopic surgery.\n \n \n \n\n\n \n Szavay, P. O.; Zundel, S.; Blumenstock, G.; Kirschner, H. J.; Luithle, T.; Girisch, M.; Luenig, H.; and Fuchs, J.\n\n\n \n\n\n\n Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A, 21(5): 439–443. June 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{szavay_perioperative_2011,\n\ttitle = {Perioperative outcome of patients with esophageal atresia and tracheo-esophageal fistula undergoing open versus thoracoscopic surgery},\n\tvolume = {21},\n\tissn = {1557-9034},\n\tdoi = {10.1089/lap.2010.0349},\n\tabstract = {INTRODUCTION: Thoracoscopic approach for repair of esophageal atresia (EA) and tracheo-esophageal fistula (TEF) has become a standard procedure in many pediatric surgical centers. Thoracoscopic surgery in a newborn is demanding from both the surgeon and the patient. The potential benefits for the newborn are still discussed by neonatologists, pediatric intensive care physicians, and also parents. The aim of our investigation was to clearly define perioperative outcome and complication rates in children undergoing thoracoscopic versus open surgery for EA and TEF repair.\nPATIENTS AND METHODS: We reviewed the records of 68 newborns undergoing surgery for EA and TEF between March 2002 and February 2010. Patient data of open versus thoracoscopic approach were compared regarding operating time, intraoperative as well as postoperative pCO(2)max values, postoperative ventilation time, and complications. Specific patient data are reported with the median and range. Data analysis was done with the JMP(®) 7.0.2 statistical software (SAS Institute, Cary, NC).\nRESULTS: For the 68 patients, the mean gestational age was 35 weeks (28-41), the median birth weight was 2720 g (1500-3510 g) in the thoracoscopic group and 2090 g (780-3340 g) in the open group. There were 36 girls and 32 boys. Thirty-two children had associated anomalies. Twenty-five children were undergoing a thoracoscopic procedure. In 8 cases, the operation was converted to open thoracotomy. Another 32 children received a thoracotomy. In 11 newborns, a cervical esophagostomy was performed because of long-gap EA and these patients were excluded from the study. Operating time was 141 minutes (77-201 minutes) in the thoracoscopic group and 106 minutes (48-264 minutes) in the thoracotomy group, with significant difference (P=.014). Values of pCO(2)max during operation were 62 mm Hg (34-101 mm Hg) in the thoracoscopic group and 48 mm Hg (28-89 mm Hg) in the open group, with significant difference (P=.014). Postoperative ventilation time was 3 days (1-51 days) in all groups, with no significant difference (P=.79). Early complications were noticed in 9 children undergoing thoracoscopy and in 8 patients of the thoracotomy group, again with no significant difference (P{\\textgreater}.05).\nCONCLUSION: Thoracoscopic repair of EA with TEF is justified because of a comparable perioperative outcome to open surgery, competitive operating times, decreased trauma to the thoracic cavity, and improved cosmesis despite skeptical considerations. Complication rates are not higher than in children operated on through a thoracotomy. However, a learning curve has to be taken into account and large experience in minimal invasive surgery is mandatory for this procedure. Larger series have to be expected for a more objective evaluation of perioperative as well as long-term outcomes. To our opinion, the thoracoscopic approach appears to be favorable and could be a future standard.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Journal of Laparoendoscopic \\& Advanced Surgical Techniques. Part A},\n\tauthor = {Szavay, Philipp O. and Zundel, Sabine and Blumenstock, Gunnar and Kirschner, Hans Joachim and Luithle, Tobias and Girisch, Monika and Luenig, Holger and Fuchs, Joerg},\n\tmonth = jun,\n\tyear = {2011},\n\tpmid = {21486154},\n\tkeywords = {Digestive System Surgical Procedures, Esophageal Atresia, Female, Humans, Infant, Newborn, Male, Retrospective Studies, Thoracoscopy, Tracheoesophageal Fistula, Treatment Outcome},\n\tpages = {439--443},\n}\n\n\n\n\n\n\n\n

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\n INTRODUCTION: Thoracoscopic approach for repair of esophageal atresia (EA) and tracheo-esophageal fistula (TEF) has become a standard procedure in many pediatric surgical centers. Thoracoscopic surgery in a newborn is demanding from both the surgeon and the patient. The potential benefits for the newborn are still discussed by neonatologists, pediatric intensive care physicians, and also parents. The aim of our investigation was to clearly define perioperative outcome and complication rates in children undergoing thoracoscopic versus open surgery for EA and TEF repair. PATIENTS AND METHODS: We reviewed the records of 68 newborns undergoing surgery for EA and TEF between March 2002 and February 2010. Patient data of open versus thoracoscopic approach were compared regarding operating time, intraoperative as well as postoperative pCO(2)max values, postoperative ventilation time, and complications. Specific patient data are reported with the median and range. Data analysis was done with the JMP(®) 7.0.2 statistical software (SAS Institute, Cary, NC). RESULTS: For the 68 patients, the mean gestational age was 35 weeks (28-41), the median birth weight was 2720 g (1500-3510 g) in the thoracoscopic group and 2090 g (780-3340 g) in the open group. There were 36 girls and 32 boys. Thirty-two children had associated anomalies. Twenty-five children were undergoing a thoracoscopic procedure. In 8 cases, the operation was converted to open thoracotomy. Another 32 children received a thoracotomy. In 11 newborns, a cervical esophagostomy was performed because of long-gap EA and these patients were excluded from the study. Operating time was 141 minutes (77-201 minutes) in the thoracoscopic group and 106 minutes (48-264 minutes) in the thoracotomy group, with significant difference (P=.014). Values of pCO(2)max during operation were 62 mm Hg (34-101 mm Hg) in the thoracoscopic group and 48 mm Hg (28-89 mm Hg) in the open group, with significant difference (P=.014). Postoperative ventilation time was 3 days (1-51 days) in all groups, with no significant difference (P=.79). Early complications were noticed in 9 children undergoing thoracoscopy and in 8 patients of the thoracotomy group, again with no significant difference (P\\textgreater.05). CONCLUSION: Thoracoscopic repair of EA with TEF is justified because of a comparable perioperative outcome to open surgery, competitive operating times, decreased trauma to the thoracic cavity, and improved cosmesis despite skeptical considerations. Complication rates are not higher than in children operated on through a thoracotomy. However, a learning curve has to be taken into account and large experience in minimal invasive surgery is mandatory for this procedure. Larger series have to be expected for a more objective evaluation of perioperative as well as long-term outcomes. To our opinion, the thoracoscopic approach appears to be favorable and could be a future standard.\n

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\n \n\n \n \n \n \n \n Endoscopic balloon dilatation for esophageal strictures in children younger than 6 years: experience in a medical center.\n \n \n \n\n\n \n Chang, C.; Kuo, S.; Lin, H.; Chuang, C.; Tsai, T.; Wu, S.; Chen, A.; Chen, W.; and Peng, C.\n\n\n \n\n\n\n Pediatrics and Neonatology, 52(4): 196–202. August 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{chang_endoscopic_2011,\n\ttitle = {Endoscopic balloon dilatation for esophageal strictures in children younger than 6 years: experience in a medical center},\n\tvolume = {52},\n\tissn = {1875-9572},\n\tshorttitle = {Endoscopic balloon dilatation for esophageal strictures in children younger than 6 years},\n\tdoi = {10.1016/j.pedneo.2011.05.005},\n\tabstract = {Esophageal strictures in children may be caused by congenital anomaly, caustic agent or foreign body ingestion, complication of reflux esophagitis, and after esophageal surgery. Accidental ingestion of alkaline fluid is the most common cause of corrosive esophagitis in children in Taiwan. In this article, we studied 10 pediatric patients who had esophageal strictures and required endoscopic balloon dilatation (EBD) therapy under general anesthesia from January 2003 to June 2009. The median age of the studied children who received their first EBD treatment was 36.2 months (13.4-60.9 months), with a dilator size of 8.0mm (5-12 mm). The interval between injury and initial EBD was 3.0 months (1.3-60.8 months). The treatment duration averaged 16.7 months (3.0-69.3 months), with 13.5 (4-31) instances of EBD therapy per patient. The greater the length of stricture, the more number of times EBD was needed. In these cases, no severe complication was found after the procedure. The result indicated that EBD under general anesthesia was a safe and effective method to resolve the symptom of dysphagia and diet condition. Because of the limited number of study cases, long-term studies are required to further confirm the clinical effect of EBD under general anesthesia.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Pediatrics and Neonatology},\n\tauthor = {Chang, Chih-Feng and Kuo, Shih-Pin and Lin, Hung-Chih and Chuang, Chun-Chun and Tsai, Tien-Kai and Wu, Shu-Fen and Chen, An-Chyi and Chen, Walter and Peng, Ching-Tien},\n\tmonth = aug,\n\tyear = {2011},\n\tpmid = {21835364},\n\tkeywords = {Catheterization, Child, Preschool, Esophageal Stenosis, Esophagoscopy, Female, Humans, Infant, Male, Retrospective Studies},\n\tpages = {196--202},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Gastroesophageal reflux in young children treated for esophageal atresia: evaluation with pH-multichannel intraluminal impedance.\n \n \n \n\n\n \n Catalano, P.; Di Pace, M. R.; Caruso, A. M.; Casuccio, A.; and De Grazia, E.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 52(6): 686–690. June 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{catalano_gastroesophageal_2011,\n\ttitle = {Gastroesophageal reflux in young children treated for esophageal atresia: evaluation with {pH}-multichannel intraluminal impedance},\n\tvolume = {52},\n\tissn = {1536-4801},\n\tshorttitle = {Gastroesophageal reflux in young children treated for esophageal atresia},\n\tdoi = {10.1097/MPG.0b013e318202a3e5},\n\tabstract = {OBJECTIVES: Gastroesophageal reflux (GER) and dismotility occur frequently after repair of esophageal atresia (EA). GER-associated complications can manifest either early or later; then precocious diagnosis and treatment are essential. The aim of the study was to evaluate characteristics of GER and esophageal clearance in children treated for EA with distal tracheoesophageal fistula, using pH-multichannel intraluminal impedance (pH-MII).\nPATIENTS AND METHODS: Twenty-two children (ages 3-40 months) treated for EA at birth, and 20 normal children of similar age with suspected GER disease were included in the study. Impedance parameters were analyzed according to age and symptoms.\nRESULTS: Reflux events were mainly nonacidic. About bolus exposure index, mean acid clearing time (MACT), and mean bolus clearing time (MBCT), a significant difference was found between 2 groups: the median MACT and MBCT were longer, with values of 281 and 39 seconds, respectively, in the EA group and 110 and 15 seconds in the control group (P {\\textless} 0.0005).\nCONCLUSIONS: Our data show that in young patients the majority of refluxes are not acid. This implies that the incidence of GER may be underestimated if pH-metry is used. The pH-MII is an ideal test in children because it studies both GER with its characteristics and motility pattern. The quality of reflux does not seem to influence the onset of symptoms that are related to an impaired esophageal clearance. Hence, this technique could be useful to study patients treated for EA, avoiding the onset of complications.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Catalano, Pieralba and Di Pace, Maria R. and Caruso, Anna M. and Casuccio, Alessandra and De Grazia, Enrico},\n\tmonth = jun,\n\tyear = {2011},\n\tpmid = {21597403},\n\tkeywords = {Case-Control Studies, Child, Preschool, Esophageal Atresia, Esophageal pH Monitoring, Esophagus, Gastric Acid, Gastroesophageal Reflux, Gastrointestinal Transit, Humans, Hydrogen-Ion Concentration, Infant, Postoperative Complications, Tracheoesophageal Fistula},\n\tpages = {686--690},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Safety and efficacy of high-dose acarbose treatment for dumping syndrome.\n \n \n \n\n\n \n De Cunto, A.; Barbi, E.; Minen, F.; and Ventura, A.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 53(1): 113–114. July 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{de_cunto_safety_2011,\n\ttitle = {Safety and efficacy of high-dose acarbose treatment for dumping syndrome},\n\tvolume = {53},\n\tissn = {1536-4801},\n\tdoi = {10.1097/MPG.0b013e31820ae6d1},\n\tabstract = {Dumping syndrome (DS) is a complication of Nissen fundoplication. Dietary strategies can ameliorate symptoms, but this approach is not always foolproof. Limited evidence reports the efficacy of acarbose for children who are unresponsive to feeding manipulations. We report 8 patients with DS aged between 7 and 24 months. In 4 of 8 nutritional strategies failed, and acarbose treatment was started. The initial dose was 25 mg for meals, and increased until postprandial glucose was stable. In 3 of 4 children the final dose was higher than previously reported, without adverse effects. Acarbose is useful to treat DS in cases of failure of dietary strategies.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {De Cunto, Angela and Barbi, Egidio and Minen, Federico and Ventura, Alessandro},\n\tmonth = jul,\n\tyear = {2011},\n\tpmid = {21694549},\n\tkeywords = {Acarbose, Child, Preschool, Dumping Syndrome, Female, Humans, Hyperglycemia, Hypoglycemic Agents, Infant, Male, Postprandial Period, Treatment Outcome},\n\tpages = {113--114},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n A rare association of inlet patch with laryngospasm: a report of two children and literature review.\n \n \n \n\n\n \n di Palmo, E.; Cazzato, S.; Tursini, S.; Salfi, N. C. M.; Mazzotta, A.; Di Silverio Carulli, C.; Lima, M.; Bergamaschi, R.; Bernardi, F.; and Cicognani, A.\n\n\n \n\n\n\n Pediatric Pulmonology, 46(9): 934–938. September 2011.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{di_palmo_rare_2011,\n\ttitle = {A rare association of inlet patch with laryngospasm: a report of two children and literature review},\n\tvolume = {46},\n\tissn = {1099-0496},\n\tshorttitle = {A rare association of inlet patch with laryngospasm},\n\tdoi = {10.1002/ppul.21457},\n\tabstract = {The inlet patch (IP) is an area of heterotopic gastric mucosa in the cervical esophagus commonly seen during upper endoscopy. Although generally asymptomatic IP has been associated with esophageal and supraesophageal symptoms and, though rare, in adult with malignant transformation. We describe two cases of recurrent episodes of laryngospasm associated with IP. In both cases there was a good response to prolonged acid suppression therapy.},\n\tlanguage = {eng},\n\tnumber = {9},\n\tjournal = {Pediatric Pulmonology},\n\tauthor = {di Palmo, E. and Cazzato, S. and Tursini, S. and Salfi, N. C. M. and Mazzotta, A. and Di Silverio Carulli, C. and Lima, M. and Bergamaschi, R. and Bernardi, F. and Cicognani, A.},\n\tmonth = sep,\n\tyear = {2011},\n\tpmid = {21462362},\n\tkeywords = {Alginates, Anti-Ulcer Agents, Child, Child, Preschool, Esophageal Diseases, Female, Gastric Mucosa, Glucuronic Acid, Hexuronic Acids, Humans, Laryngismus, Omeprazole, Ranitidine, Severity of Illness Index, Treatment Outcome},\n\tpages = {934--938},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Why organize a workshop on esophageal atresia?.\n \n \n \n \n\n\n \n Gottrand, F.; Sfeir, R.; and Michaud, L.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 52 Suppl 1: S1. May 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Why$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{gottrand_why_2011,\n\ttitle = {Why organize a workshop on esophageal atresia?},\n\tvolume = {52 Suppl 1},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21499033/},\n\tdoi = {10.1097/MPG.0b013e3182116187},\n\tlanguage = {eng},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Gottrand, Frédéric and Sfeir, Rony and Michaud, Laurent},\n\tmonth = may,\n\tyear = {2011},\n\tpmid = {21499033},\n\tkeywords = {Esophageal Atresia, Humans, Incidence, Infant, Newborn, Neonatal Screening, Prognosis, Rare Diseases, Survival Rate},\n\tpages = {S1},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Management of severe tracheomalacia.\n \n \n \n \n\n\n \n Fayoux, P.; and Sfeir, R.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 52 Suppl 1: S33–34. May 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Management$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{fayoux_management_2011,\n\ttitle = {Management of severe tracheomalacia},\n\tvolume = {52 Suppl 1},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21499044/},\n\tdoi = {10.1097/MPG.0b013e3182132d76},\n\tlanguage = {eng},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Fayoux, Pierre and Sfeir, Rony},\n\tmonth = may,\n\tyear = {2011},\n\tpmid = {21499044},\n\tkeywords = {Esophageal Atresia, Humans, Trachea, Tracheal Stenosis, Tracheomalacia},\n\tpages = {S33--34},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Inlet patch: clinical presentation and outcome in children.\n \n \n \n \n\n\n \n Georges, A.; Coopman, S.; Rebeuh, J.; Molitor, G.; Rebouissoux, L.; Dabadie, A.; Kalach, N.; Lachaux, A.; and Michaud, L.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 52(4): 419–423. April 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Inlet$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{georges_inlet_2011,\n\ttitle = {Inlet patch: clinical presentation and outcome in children},\n\tvolume = {52},\n\tissn = {1536-4801},\n\tshorttitle = {Inlet patch},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21499037/},\n\tdoi = {10.1097/MPG.0b013e3181f2a913},\n\tabstract = {OBJECTIVES: An inlet patch (IP) is defined as heterotopic gastric mucosa located in the proximal esophagus. Little information is available in children. The aim of this retrospective study was to assess clinical significance, endoscopic and histological characteristics, and natural history of IP in children.\nPATIENTS AND METHODS: This retrospective multicenter study included all of the cases of IP recorded in 7 tertiary French pediatric gastrointestinal centers. Information about demographics, clinical symptoms, endoscopic characteristics, histology, treatment, and evolution was collected.\nRESULTS: Fifteen children were included (8 boys, 7 girls). The median age at diagnosis was 9.5 years (range 3.3-15 years). Five children had esophageal atresia and 9 had gastroesophageal reflux. Only 1 child was asymptomatic. Digestive symptoms (dysphagia, food impaction) were noted in 14 patients and respiratory or ear, nose, and throat symptoms in 6. At endoscopy, IP was characterized by a small, round salmon-pink lesion of the proximal esophagus. Helicobacter pylori was found in 2 patients. Proton pump inhibitor treatment was initiated in 14 children for a mean duration of 4.7 months (range 1-12 months). Two patients were lost to follow-up. Clinical symptoms disappeared in 5 patients and decreased in 3 others. One case of hematemesis was noted after a mean follow-up of 9 months. Recurrent symptoms were noted in 2 patients after treatment discontinuation.\nCONCLUSIONS: IP is an uncommon but almost certainly underrecognized lesion in children, and may be the cause of digestive and respiratory symptoms in some children.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Georges, Amandine and Coopman, Stéphanie and Rebeuh, Julie and Molitor, Guy and Rebouissoux, Laurent and Dabadie, Alain and Kalach, Nicolas and Lachaux, Alain and Michaud, Laurent},\n\tmonth = apr,\n\tyear = {2011},\n\tpmid = {21240021},\n\tkeywords = {Adolescent, Child, Child, Preschool, Choristoma, Endoscopy, Gastrointestinal, Esophageal Atresia, Esophageal Diseases, Female, France, Gastric Mucosa, Gastroesophageal Reflux, Humans, Male, Proton Pump Inhibitors, Retrospective Studies},\n\tpages = {419--423},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Hypopharyngeal pharyngoplasty in the treatment of severe aspiration following skull base tumor removal: experience in pediatric patients.\n \n \n \n \n\n\n \n Fayoux, P.; Bonne, N. X.; and Hosana, G.\n\n\n \n\n\n\n Archives of Otolaryngology–Head & Neck Surgery, 137(1): 60–64. January 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Hypopharyngeal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{fayoux_hypopharyngeal_2011,\n\ttitle = {Hypopharyngeal pharyngoplasty in the treatment of severe aspiration following skull base tumor removal: experience in pediatric patients},\n\tvolume = {137},\n\tissn = {1538-361X},\n\tshorttitle = {Hypopharyngeal pharyngoplasty in the treatment of severe aspiration following skull base tumor removal},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21242548/},\n\tdoi = {10.1001/archoto.2010.233},\n\tabstract = {OBJECTIVE: To report the surgical treatment of severe swallowing disorders associated with skull base surgery resulting in unilateral pharyngolaryngeal paralysis in pediatric patients.\nDESIGN: Retrospective case review.\nSETTING: Tertiary referral center for pediatric otolaryngology.\nPATIENTS: Five infants undergoing swallowing rehabilitation surgery for severe dysphagia and aspiration resulting from skull base or brainstem surgery.\nINTERVENTION: A hypopharyngeal pharyngoplasty, consisting of the partial resection of the inferior constrictor and cricopharyngeal muscles, was performed for the treatment of severe swallowing disorders. A thyroplasty was also performed if clinically significant glottic incompetence was present.\nMAIN OUTCOME MEASURES: Functional outcomes after surgery were evaluated with a videoendoscopic swallowing study and videofluoroscopy. Postoperative clinical evaluation included respiratory, swallowing, and nutritional outcomes.\nRESULTS: A hypopharyngeal pharyngoplasty was performed following a mean period of 6 weeks (range, 1-10 weeks) after skull base surgery. In 3 patients a thyroplasty and a temporary tracheotomy were performed. Oral feeding was reintroduced after a mean period of 6 days (range, 4-20 days). Complete oral feeding autonomy was obtained after 13 days (range, 7-25 days). Postoperative swallowing assessment revealed the disappearance of pharyngeal stasis and aspiration in all patients. Three infants died because of tumor recurrence. Neither dysphagia or bronchopulmonary infections were observed after a mean follow-up period of 33 months (range, 6-61 months).\nCONCLUSIONS: Pharyngolaryngeal paralysis represents a severe consequence of skull base and brainstem surgery. This condition leads to high morbidity, particularly in the pediatric population. The hypopharyngeal pharyngoplasty, with a possible thyroplasty, may be considered to treat patients with severe pharyngolaryngeal paralysis after skull base or brainstem surgery.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Archives of Otolaryngology--Head \\& Neck Surgery},\n\tauthor = {Fayoux, Pierre and Bonne, Nicolas X. and Hosana, Gregory},\n\tmonth = jan,\n\tyear = {2011},\n\tpmid = {21242548},\n\tkeywords = {Child, Preschool, Deglutition Disorders, Ependymoma, Female, Humans, Hypopharynx, Infant, Laryngoscopy, Male, Neurosurgical Procedures, Paralysis, Pharynx, Pneumonia, Aspiration, Postoperative Complications, Prognosis, Retrospective Studies, Risk Assessment, Severity of Illness Index, Skull Base Neoplasms, Survival Rate, Treatment Outcome, Vocal Cord Paralysis},\n\tpages = {60--64},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Clinical and manometric characteristics of Allgrove syndrome.\n \n \n \n \n\n\n \n Alhussaini, B.; Gottrand, F.; Goutet, J.; Scaillon, M.; Michaud, L.; Spyckerelle, C.; Viola, S.; and Lamblin, M.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 53(3): 271–274. September 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Clinical$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{alhussaini_clinical_2011,\n\ttitle = {Clinical and manometric characteristics of {Allgrove} syndrome},\n\tvolume = {53},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21865973/},\n\tdoi = {10.1097/MPG.0b013e31821456ba},\n\tabstract = {OBJECTIVE: The association of adrenocorticotropic hormone (ACTH) insensitivity with achalasia and alacrimia (Allgrove syndrome, 3A) constitutes a rare multisystem disorder. Its evolution is not well known. The aim of this study was to describe clinical and esophageal manometric characteristics and outcomes in Allgrove syndrome.\nPATIENTS AND METHODS: This multicenter retrospective study compared clinical and manometric characteristics at diagnosis and on follow-up of 9 children presenting with 3A (mean age at diagnosis 7.1 years) with those of 9 children with idiopathic achalasia (IA) (mean age at diagnosis 8.3 years).\nRESULTS: At the time of diagnosis, 3 children with 3A presented with no digestive or respiratory signs because they were identified during a family screening; 1 remained asymptomatic 8 years later. ACTH levels were high in patients with 3A. All of the patients with IA were symptomatic at diagnosis. No significant difference was observed when comparing any of the manometric parameters of the first esophageal manometry of 3A with those of IA. Seven children with 3A were operated on using the Heller procedure, completed by pneumatic esophageal dilation in 2 of these 7. One patient with 3A was treated only by nifedipine. Failure of treatment was observed in 3 children with 3A and 1 child with IA, partial success in 4 with 3A and 1 with IA, and total success in 2 with 3A and 7 with IA (P {\\textless} 0.03). Control manometry showed that in the 3A group, partial success after surgery was always associated with abnormally low or normal lower esophageal sphincter (LES) pressure, whereas failure after surgery was associated with high LES pressure.\nCONCLUSIONS: Our data showed that 3A presented a more severe course than IA despite presymptomatic diagnosis in cases of family screening. The high LES pressure noted in some patients with 3A is suggestive of a peculiar pattern in 3A affecting the LES and the lower part of the esophagus.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Alhussaini, Bakr and Gottrand, Frédéric and Goutet, Jean-Michel and Scaillon, Michèle and Michaud, Laurent and Spyckerelle, Claire and Viola, Sheila and Lamblin, Marie-Dominique},\n\tmonth = sep,\n\tyear = {2011},\n\tpmid = {21865973},\n\tkeywords = {Adrenal Insufficiency, Child, Child, Preschool, Esophageal Achalasia, Esophageal Sphincter, Lower, Female, Follow-Up Studies, Humans, Male, Manometry, Retrospective Studies},\n\tpages = {271--274},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Choanal atresia associated with tracheoesophageal fistula: the spectrum of carbimazole embryopathy.\n \n \n \n \n\n\n \n Douchement, D.; Rakza, T.; Holder, M.; Bonne, N.; and Fayoux, P.\n\n\n \n\n\n\n Pediatrics, 128(3): e703–706. September 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Choanal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{douchement_choanal_2011,\n\ttitle = {Choanal atresia associated with tracheoesophageal fistula: the spectrum of carbimazole embryopathy},\n\tvolume = {128},\n\tissn = {1098-4275},\n\tshorttitle = {Choanal atresia associated with tracheoesophageal fistula},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21807695/},\n\tdoi = {10.1542/peds.2010-0945},\n\tabstract = {This article focuses on the case of a newborn infant boy with bilateral choanal atresia, tracheoesophageal fistula, and bilateral fifth-finger clinodactyly. This infant had been exposed to carbimazole in utero during the treatment of maternal Graves disease. Teratogenic defects caused by carbimazole were recently recognized, and their phenotypes have been defined. Choanal atresia, esophageal atresia, athelia or hypothelia, developmental delay, hearing loss, and dysmorphic facial features have all been reported. To our knowledge, this is the first documented case of tracheoesophageal fistula without esophageal atresia (H type). Knowledge of the teratogenic potential of carbimazole is important when managing Graves disease in women of childbearing age.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Pediatrics},\n\tauthor = {Douchement, Dorothée and Rakza, Thameur and Holder, Muriel and Bonne, Nicolas-Xavier and Fayoux, Pierre},\n\tmonth = sep,\n\tyear = {2011},\n\tpmid = {21807695},\n\tkeywords = {Antithyroid Agents, Carbimazole, Choanal Atresia, Endoscopy, Female, Graves Disease, Humans, Infant, Newborn, Male, Pregnancy, Prenatal Exposure Delayed Effects, Tracheoesophageal Fistula},\n\tpages = {e703--706},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Anastomotic strictures: conservative treatment.\n \n \n \n \n\n\n \n Michaud, L.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 52 Suppl 1: S18–19. May 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Anastomotic$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{michaud_anastomotic_2011,\n\ttitle = {Anastomotic strictures: conservative treatment},\n\tvolume = {52 Suppl 1},\n\tissn = {1536-4801},\n\tshorttitle = {Anastomotic strictures},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21499037/},\n\tdoi = {10.1097/MPG.0b013e3182105ad1},\n\tlanguage = {eng},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Michaud, Laurent and Gottrand, Frédéric},\n\tmonth = may,\n\tyear = {2011},\n\tpmid = {21499037},\n\tkeywords = {Anastomosis, Surgical, Antibiotics, Antineoplastic, Constriction, Pathologic, Esophageal Atresia, Humans, Mitomycin, Postoperative Complications, Recurrence},\n\tpages = {S18--19},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Bioartificial oesophagus in the era of tissue engineering.\n \n \n \n \n\n\n \n Poghosyan, T.; Gaujoux, S.; Sfeir, R.; Larghero, J.; and Cattan, P.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 52 Suppl 1: S16–17. May 2011.\n \n\n\n\n
\n\n\n\n \n \n $\"Bioartificial$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{poghosyan_bioartificial_2011,\n\ttitle = {Bioartificial oesophagus in the era of tissue engineering},\n\tvolume = {52 Suppl 1},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21499036/},\n\tdoi = {10.1097/MPG.0b013e3182105964},\n\tlanguage = {eng},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Poghosyan, Tigran and Gaujoux, Sebastien and Sfeir, Rony and Larghero, Jerome and Cattan, Pierre},\n\tmonth = may,\n\tyear = {2011},\n\tpmid = {21499036},\n\tkeywords = {Bioartificial Organs, Esophageal Atresia, Humans, Infant, Newborn, Intercellular Signaling Peptides and Proteins, Tissue Culture Techniques, Tissue Engineering},\n\tpages = {S16--17},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Dumping syndrome after esophageal atresia repair without antireflux surgery.\n \n \n \n \n\n\n \n Michaud, L.; Sfeir, R.; Couttenier, F.; Turck, D.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 45(4): E13–15. April 2010.\n \n\n\n\n
\n\n\n\n \n \n $\"Dumping$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{michaud_dumping_2010,\n\ttitle = {Dumping syndrome after esophageal atresia repair without antireflux surgery},\n\tvolume = {45},\n\tissn = {1531-5037},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/20385264/},\n\tdoi = {10.1016/j.jpedsurg.2010.01.016},\n\tabstract = {In childhood, the surgical treatment of gastroesophageal reflux is the main cause of dumping syndrome. We report the cases of 2 children with esophageal atresia who presented with dumping syndrome without any precipitating known factors, such as gastroesophageal reflux surgery or associated microgastria. Our data suggest (1) that dumping syndrome can occur after primary anastomosis of esophageal atresia without antireflux surgery and (2) that dumping syndrome should be considered in every child treated surgically for esophageal atresia presenting with digestive symptoms, malaise, failure to thrive, or refusal to eat.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Michaud, Laurent and Sfeir, Rony and Couttenier, Frédéric and Turck, Dominique and Gottrand, Frédéric},\n\tmonth = apr,\n\tyear = {2010},\n\tpmid = {20385264},\n\tkeywords = {Anastomosis, Surgical, Dumping Syndrome, Esophageal Atresia, Humans, Infant, Male},\n\tpages = {E13--15},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n 13-year follow-up of a prospective comparison of the long-term clinical efficacy of temporary self-expanding metallic stents and pneumatic dilatation for the treatment of achalasia in 120 patients.\n \n \n \n\n\n \n Li, Y.; Tang, G.; Cheng, Y.; Chen, N.; Chen, W.; and Zhao, J.\n\n\n \n\n\n\n AJR. American journal of roentgenology, 195(6): 1429–1437. December 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{li_13-year_2010,\n\ttitle = {13-year follow-up of a prospective comparison of the long-term clinical efficacy of temporary self-expanding metallic stents and pneumatic dilatation for the treatment of achalasia in 120 patients},\n\tvolume = {195},\n\tissn = {1546-3141},\n\tdoi = {10.2214/AJR.10.4407},\n\tabstract = {OBJECTIVE: The purpose of this article is to compare the efficacy of self-expanding metallic stents and pneumatic dilation for the long-term clinical treatment of achalasia.\nSUBJECTS AND METHODS: Patients diagnosed with achalasia (n = 120) were allocated for treatment with pneumatic dilation (n = 30; group A) or a temporary self-expanding metallic stent with a diameter of 20 mm (n = 30; group B), 25 mm (n = 30; group C), or 30 mm (n = 30; group D). Data on clinical symptoms, complications, and long-term clinical outcomes were collected, and follow-up was performed at 6 months and at 1, 3-5, 5-8, 8-10, and more than 10 years after surgery.\nRESULTS: Pneumatic dilation and stent placement were technically successful in all patients. The follow-up at more than 10 years revealed that the clinical remission rate in group D (83.3\\%) was higher than that in groups A (0\\%), B (0\\%), and C (28.6\\%), and the overall cumulative clinical failure rate in group D (13\\%) was lower than that in groups A (76.7\\%), B (53.3\\%), and C (26.7\\%). Patients in group D exhibited reduced dysphagia scores and lower esophageal sphincter pressures and had normal levels of barium height and width during the follow-up periods, whereas these markers increased with time in the other groups. The duration of primary patency in group D was also longer than that in groups A, B, and C.\nCONCLUSION: A temporary self-expanding metallic stent with a diameter of 30 mm has superior clinical efficacy for the treatment of achalasia compared with pneumatic dilation or self-expanding metallic stents with diameters of 20 or 25 mm.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {AJR. American journal of roentgenology},\n\tauthor = {Li, Yong-Dong and Tang, Guang-Yu and Cheng, Ying-Sheng and Chen, Ni-Wei and Chen, Wei-Xiong and Zhao, Jun-Gong},\n\tmonth = dec,\n\tyear = {2010},\n\tpmid = {21098206},\n\tkeywords = {Adolescent, Adult, Aged, Aged, 80 and over, Chi-Square Distribution, Child, Contrast Media, Device Removal, Dilatation, Esophageal Achalasia, Female, Follow-Up Studies, Gastroscopy, Humans, Iohexol, Male, Metals, Middle Aged, Pilot Projects, Prospective Studies, Radiography, Interventional, Statistics, Nonparametric, Stents, Treatment Outcome},\n\tpages = {1429--1437},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Laparoscopic extended cardiomyotomy in children: an effective procedure for the treatment of esophageal achalasia.\n \n \n \n\n\n \n Tannuri, A. C. A.; Tannuri, U.; Velhote, M. C. P.; and Romão, R. L. P.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 45(7): 1463–1466. July 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{tannuri_laparoscopic_2010,\n\ttitle = {Laparoscopic extended cardiomyotomy in children: an effective procedure for the treatment of esophageal achalasia},\n\tvolume = {45},\n\tissn = {1531-5037},\n\tshorttitle = {Laparoscopic extended cardiomyotomy in children},\n\tdoi = {10.1016/j.jpedsurg.2009.08.023},\n\tabstract = {PURPOSE: Achalasia of the esophagus is characterized by aperistalsis and incomplete relaxation of the lower esophageal sphincter in response to swallowing. The objective of the present study is to present the experience of a modified Heller myotomy via a laparoscopic approach for the treatment of children who had this condition.\nMETHODS: A retrospective review of medical records of all patients who underwent this procedure from 2000 to 2009 was performed. The procedure consisted of an extended esophagomyotomy beginning on the lower part of the lower esophageal sphincter and continuing 5 to 6 cm above on the lower third of the esophagus, and then extended 3 to 4 cm below to the stomach, associated with an anterior 180-degree hemi-fundoplication according to Dor's technique.\nRESULTS: Fifteen patients were included in the study. There were 8 female and 7 male patients. Mean operating time was 190 minutes with no intraoperative complications and 1 conversion to open surgery because of difficulty in dissecting an inflamed distal esophagus. In a mean follow-up period of 32.3 months, 2 patients had recurrence of mild dysphagia that disappeared spontaneously, and 1 required a single botulinum toxin injection with complete resolution of symptoms.\nCONCLUSION: We conclude that the laparoscopic extended Heller myotomy with Dor fundoplication is a safe and effective method for the treatment for achalasia in the pediatric population even in advanced cases.},\n\tlanguage = {eng},\n\tnumber = {7},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Tannuri, Ana Cristina Aoun and Tannuri, Uenis and Velhote, Manoel Carlos Prieto and Romão, Rodrigo Luiz Pinto},\n\tmonth = jul,\n\tyear = {2010},\n\tpmid = {20638525},\n\tkeywords = {Adolescent, Cardia, Child, Esophageal Achalasia, Female, Fundoplication, Humans, Laparoscopy, Male, Minimally Invasive Surgical Procedures, Retrospective Studies},\n\tpages = {1463--1466},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Long-term esophageal cancer risk in patients with primary achalasia: a prospective study.\n \n \n \n\n\n \n Leeuwenburgh, I.; Scholten, P.; Alderliesten, J.; Tilanus, H. W.; Looman, C. W. N.; Steijerberg, E. W.; and Kuipers, E. J.\n\n\n \n\n\n\n The American Journal of Gastroenterology, 105(10): 2144–2149. October 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{leeuwenburgh_long-term_2010,\n\ttitle = {Long-term esophageal cancer risk in patients with primary achalasia: a prospective study},\n\tvolume = {105},\n\tissn = {1572-0241},\n\tshorttitle = {Long-term esophageal cancer risk in patients with primary achalasia},\n\tdoi = {10.1038/ajg.2010.263},\n\tabstract = {OBJECTIVES: Achalasia patients are considered at increased risk for esophageal cancer, but the reported relative risks vary. Identification of this risk is relevant for patient management. We performed a prospective evaluation of the esophageal cancer risk in a large cohort of achalasia patients with long-term follow-up.\nMETHODS: Between 1975 and 2006, all patients diagnosed with primary achalasia in our hospital were treated and followed by the same protocol. After graded pneumatic dilatation, all patients were offered a fixed surveillance protocol including gastrointestinal endoscopy with esophageal biopsy sampling.\nRESULTS: We surveyed a cohort of 448 achalasia patients (218 men, mean age 51 years at diagnosis, range 4-92 years) for a mean follow-up of 9.6 years (range 0.1-32). Overall, 15 (3.3\\%) patients (10 men) developed esophageal cancer (annual incidence 0.34 (95\\% confidence interval 0.20-0.56)). The mean age at cancer diagnosis was 71 years (range 36-90) after a mean of 11 years (range 2-23) following initial presentation, and a mean of 24 years (range 10-43) after symptom onset. The relative hazard rate of esophageal cancer was 28 (confidence interval 17-46) compared with an age- and sex-identical population in the same timeframe. Five patients received a potential curative treatment.\nCONCLUSIONS: Although the gastro-esophageal cancer risk in patients with longstanding achalasia is much higher than in the general population, the absolute risk is rather low. Despite structured endoscopical surveillance, most neoplastic lesions remain undetected until an advanced stage. Efforts should be made to identify high-risk groups and develop adequate surveillance strategies.},\n\tlanguage = {eng},\n\tnumber = {10},\n\tjournal = {The American Journal of Gastroenterology},\n\tauthor = {Leeuwenburgh, I. and Scholten, P. and Alderliesten, J. and Tilanus, H. W. and Looman, C. W. N. and Steijerberg, E. W. and Kuipers, E. J.},\n\tmonth = oct,\n\tyear = {2010},\n\tpmid = {20588263},\n\tkeywords = {Adolescent, Adult, Aged, Aged, 80 and over, Catheterization, Child, Child, Preschool, Cohort Studies, Esophageal Achalasia, Esophageal Neoplasms, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Prospective Studies, Risk, Risk Assessment},\n\tpages = {2144--2149},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n Health-related quality of life and its determinants in children and adolescents born with oesophageal atresia.\n \n \n \n\n\n \n Peetsold, M. G.; Heij, H. A.; Deurloo, J. A.; and Gemke, R. J. B. J.\n\n\n \n\n\n\n Acta Paediatrica (Oslo, Norway: 1992), 99(3): 411–417. March 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{peetsold_health-related_2010,\n\ttitle = {Health-related quality of life and its determinants in children and adolescents born with oesophageal atresia},\n\tvolume = {99},\n\tissn = {1651-2227},\n\tdoi = {10.1111/j.1651-2227.2009.01579.x},\n\tabstract = {AIM: Following surgical correction in the neonatal period, patients born with oesophageal atresia have significant co-morbidity, particularly in childhood. This study evaluates health-related quality of life and its determinants such as concomitant anomalies and the presence of respiratory and/or gastro-intestinal symptoms 6-18 years after repair of oesophageal atresia.\nMETHODS: Parents of 24 patients with oesophageal atresia completed the child health questionnaire for parents and 37 patients completed the child form. Gastro-intestinal symptoms were assessed by a validated standardized reflux questionnaire. Results were compared with a healthy reference population.\nRESULTS: Parents as well as patients themselves scored significantly lower on the domain general health perception. According to parents, general health perception was negatively affected by age at follow-up and concomitant anomalies. Patients reported that reflux symptoms reduced general health perception.\nCONCLUSION: In this first study describing health-related quality of life in children and adolescents born with oesophageal atresia, we demonstrated that general health remains impaired because of a high incidence of concomitant anomalies and gastrointestinal symptoms in patients with oesophageal atresia when compared with the healthy reference population.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Acta Paediatrica (Oslo, Norway: 1992)},\n\tauthor = {Peetsold, M. G. and Heij, H. A. and Deurloo, J. A. and Gemke, R. J. B. J.},\n\tmonth = mar,\n\tyear = {2010},\n\tpmid = {19912137},\n\tkeywords = {Adolescent, Case-Control Studies, Child, Comorbidity, Esophageal Atresia, Female, Follow-Up Studies, Gastroesophageal Reflux, Health Status, Health Surveys, Humans, Male, Outcome Assessment, Health Care, Parents, Quality of Life, Regression Analysis, Surveys and Questionnaires},\n\tpages = {411--417},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Polyalanine expansion in the ZIC3 gene leading to X-linked heterotaxy with VACTERL association: a new polyalanine disorder?.\n \n \n \n\n\n \n Wessels, M. W.; Kuchinka, B.; Heydanus, R.; Smit, B. J.; Dooijes, D.; de Krijger, R. R.; Lequin, M. H.; de Jong, E. M.; Husen, M.; Willems, P. J.; and Casey, B.\n\n\n \n\n\n\n Journal of Medical Genetics, 47(5): 351–355. May 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{wessels_polyalanine_2010,\n\ttitle = {Polyalanine expansion in the {ZIC3} gene leading to {X}-linked heterotaxy with {VACTERL} association: a new polyalanine disorder?},\n\tvolume = {47},\n\tissn = {1468-6244},\n\tshorttitle = {Polyalanine expansion in the {ZIC3} gene leading to {X}-linked heterotaxy with {VACTERL} association},\n\tdoi = {10.1136/jmg.2008.060913},\n\tabstract = {BACKGROUND: The VACTERL association is a non-random association of congenital defects with an unknown aetiology in the majority of patients.\nMETHODS: A male newborn is reported with features of the VACTERL association, including anal atresia, laryngeal and oesophageal atresia with tracheo-oesophageal fistula, dextroposition of the heart with persistent left superior vena cava, and unilateral multicystic kidney. As the clinical picture of this patient overlaps with that of X-linked heterotaxy caused by ZIC3 mutations, the ZIC3 coding region was sequenced.\nRESULTS: In a patient with the VACTERL association a 6-nucleotide insertion was found in the GCC repeat of the ZIC3 gene, which is predicted to expand the amino-terminal polyalanine repeat from 10 to 12 polyalanines. The polyalanine expansion is a novel ZIC3 mutation which was not found in 336 chromosomes from 192 ethnically matched controls. The mutation was also not present in the mother, suggesting it occurred de novo in the patient and is therefore a pathogenetic mutation.\nCONCLUSION: It is hypothesized that this novel and de novo polyalanine expansion in ZIC3 contributes to the VACTERL association in this patient. A newborn male is described with features of the VACTERL association, including anal atresia, laryngeal and oesophageal atresia with tracheo-oesophageal fistula, dextroposition of the heart with persistent left superior vena cava, and unilateral multicystic kidney. As the clinical picture of the VACTERL association overlaps with X-linked heterotaxy caused by ZIC3 mutations, the ZIC3 coding region was sequenced, and a 6-nucleotide insertion was found that is predicted to expand the amino-terminal polyalanine repeat from 10 to 12 polyalanines. This novel mutation was not present in the mother, nor in 336 chromosomes from 192 ethnically matched controls. It is hypothesised that this novel and de novo polyalanine expansion in the ZIC3 gene contributes to the VACTERL association in this patient.},\n\tlanguage = {eng},\n\tnumber = {5},\n\tjournal = {Journal of Medical Genetics},\n\tauthor = {Wessels, Marja W. and Kuchinka, Brian and Heydanus, Rogier and Smit, Bert J. and Dooijes, Dennis and de Krijger, Ronald R. and Lequin, Maarten H. and de Jong, Elisabeth M. and Husen, Margreet and Willems, Patrick J. and Casey, Brett},\n\tmonth = may,\n\tyear = {2010},\n\tpmid = {20452998},\n\tkeywords = {Abnormalities, Multiple, Anus, Imperforate, Female, Genes, X-Linked, Genetic Diseases, X-Linked, Heart Defects, Congenital, Homeodomain Proteins, Humans, Infant, Newborn, Male, Peptides, Pregnancy, Transcription Factors, Trinucleotide Repeat Expansion, Zinc Fingers},\n\tpages = {351--355},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Esophageal morbidity and function in adults with repaired esophageal atresia with tracheoesophageal fistula: a population-based long-term follow-up.\n \n \n \n\n\n \n Sistonen, S. J.; Koivusalo, A.; Nieminen, U.; Lindahl, H.; Lohi, J.; Kero, M.; Kärkkäinen, P. A.; Färkkilä, M. A.; Sarna, S.; Rintala, R. J.; and Pakarinen, M. P.\n\n\n \n\n\n\n Annals of Surgery, 251(6): 1167–1173. June 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{sistonen_esophageal_2010,\n\ttitle = {Esophageal morbidity and function in adults with repaired esophageal atresia with tracheoesophageal fistula: a population-based long-term follow-up},\n\tvolume = {251},\n\tissn = {1528-1140},\n\tshorttitle = {Esophageal morbidity and function in adults with repaired esophageal atresia with tracheoesophageal fistula},\n\tdoi = {10.1097/SLA.0b013e3181c9b613},\n\tabstract = {OBJECTIVE: We assessed esophageal morbidity and relationships between surgical complications, symptoms, endoscopic findings, immunohistochemistry, and esophageal motility in adults with repaired esophageal atresia (EA).\nSUMMARY OF BACKGROUND DATA: There exist no previous population-based long-term follow-up studies on EA.\nMETHODS: Participants were interviewed, and they underwent esophageal endoscopy and manometry. Matched control subjects (n = 287) served as controls.\nRESULTS: A total of 101 (42\\%) individuals representative of the entire study population participated at a mean age of 36 years (range, 21-57). Symptomatic gastroesophageal reflux had occurred in 34\\% and dysphagia in 85\\% of the patients and in 8\\% and 2\\% of the controls (P {\\textless} 0.001 for both). Endoscopic findings included hiatal hernia (28\\%), Barrett's esophagus (11\\%), esophagitis (8\\%), and anastomotic stricture (8\\%). Immunohistochemistry revealed esophagitis in 25\\%, and CDX2-positive columnar epithelial metaplasia in 21\\%, with additional goblet cells and MUC2 positivity in 6\\%. Gastroesophageal reflux and dysphagia were equally common in individuals with normal histology, esophagitis, or epithelial metaplasia. Manometry demonstrated nonpropagating peristalsis in 80\\% of the patients, and low distal wave amplitudes of the esophagus in all the changes being significantly worse in those with epithelial metaplasia (P {\\textless} or = 0.022 metaplasia vs. esophagitis/normal). Anastomotic complications (odds ratio [OR]: 8.6-24, 95\\% confidence interval [CI]: 1.7-260, P = 0.011-0.008), age (OR: 20, 95\\% CI: 1.3-310, P = 0.034), low distal esophageal body pressure (OR: 2.6, 95\\% CI: 0.7-10, P = 0.002), and defective esophageal peristalsis (OR: 2.2, 95\\% CI: 0.4-11, P = 0.014) predicted development of epithelial metaplasia.\nCONCLUSIONS: Significant esophageal morbidity associated with EA extends into adulthood. Surgical complications, increasing age, and impaired esophageal motility predict development of epithelial metaplasia after repair of EA.},\n\tlanguage = {eng},\n\tnumber = {6},\n\tjournal = {Annals of Surgery},\n\tauthor = {Sistonen, Saara J. and Koivusalo, Antti and Nieminen, Urpo and Lindahl, Harry and Lohi, Jouko and Kero, Mia and Kärkkäinen, Päivi A. and Färkkilä, Martti A. and Sarna, Seppo and Rintala, Risto J. and Pakarinen, Mikko P.},\n\tmonth = jun,\n\tyear = {2010},\n\tpmid = {20485152},\n\tkeywords = {Adult, Barrett Esophagus, Endoscopy, Gastrointestinal, Esophageal Atresia, Esophageal Diseases, Esophagitis, Esophagus, Female, Follow-Up Studies, Gastroesophageal Reflux, Humans, Male, Manometry, Middle Aged, Tracheoesophageal Fistula},\n\tpages = {1167--1173},\n}\n\n\n\n\n\n\n\n

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\n OBJECTIVE: We assessed esophageal morbidity and relationships between surgical complications, symptoms, endoscopic findings, immunohistochemistry, and esophageal motility in adults with repaired esophageal atresia (EA). SUMMARY OF BACKGROUND DATA: There exist no previous population-based long-term follow-up studies on EA. METHODS: Participants were interviewed, and they underwent esophageal endoscopy and manometry. Matched control subjects (n = 287) served as controls. RESULTS: A total of 101 (42%) individuals representative of the entire study population participated at a mean age of 36 years (range, 21-57). Symptomatic gastroesophageal reflux had occurred in 34% and dysphagia in 85% of the patients and in 8% and 2% of the controls (P \\textless 0.001 for both). Endoscopic findings included hiatal hernia (28%), Barrett's esophagus (11%), esophagitis (8%), and anastomotic stricture (8%). Immunohistochemistry revealed esophagitis in 25%, and CDX2-positive columnar epithelial metaplasia in 21%, with additional goblet cells and MUC2 positivity in 6%. Gastroesophageal reflux and dysphagia were equally common in individuals with normal histology, esophagitis, or epithelial metaplasia. Manometry demonstrated nonpropagating peristalsis in 80% of the patients, and low distal wave amplitudes of the esophagus in all the changes being significantly worse in those with epithelial metaplasia (P \\textless or = 0.022 metaplasia vs. esophagitis/normal). Anastomotic complications (odds ratio [OR]: 8.6-24, 95% confidence interval [CI]: 1.7-260, P = 0.011-0.008), age (OR: 20, 95% CI: 1.3-310, P = 0.034), low distal esophageal body pressure (OR: 2.6, 95% CI: 0.7-10, P = 0.002), and defective esophageal peristalsis (OR: 2.2, 95% CI: 0.4-11, P = 0.014) predicted development of epithelial metaplasia. CONCLUSIONS: Significant esophageal morbidity associated with EA extends into adulthood. Surgical complications, increasing age, and impaired esophageal motility predict development of epithelial metaplasia after repair of EA.\n

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\n \n\n \n \n \n \n \n Heterotopic pancreas of the esophagus and stomach associated with pure esophageal atresia.\n \n \n \n\n\n \n Park, J.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 45(3): E25–27. March 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{park_heterotopic_2010,\n\ttitle = {Heterotopic pancreas of the esophagus and stomach associated with pure esophageal atresia},\n\tvolume = {45},\n\tissn = {1531-5037},\n\tdoi = {10.1016/j.jpedsurg.2009.12.018},\n\tabstract = {Esophageal atresia with or without tracheoeosphageal fistula is a frequent congenital malformation that may be associated with other congenital anomalies. The combination of heterotopic pancreas of the esophagus and pure esophageal atresia, however, is rare. We treated a patient with esophageal atresia without tracheoesophageal fistula (type A) associated with heterotopic pancreas of the esophagus and stomach who developed a gastric perforation.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Park, Jinyoung},\n\tmonth = mar,\n\tyear = {2010},\n\tpmid = {20223305},\n\tkeywords = {Abnormalities, Multiple, Choristoma, Digestive System Surgical Procedures, Esophageal Atresia, Esophageal Diseases, Esophagoscopy, Female, Follow-Up Studies, Humans, Immunohistochemistry, Infant, Newborn, Laparotomy, Pancreas, Risk Assessment, Stomach Diseases, Treatment Outcome},\n\tpages = {E25--27},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Congenital esophageal stenosis associated with esophageal atresia/tracheoesophageal fistula: clinical and radiologic features.\n \n \n \n\n\n \n Yoo, H. J.; Kim, W. S.; Cheon, J.; Yoo, S.; Park, K.; Jung, S.; Shin, S.; Kim, I.; and Yeon, K. M.\n\n\n \n\n\n\n Pediatric Radiology, 40(8): 1353–1359. August 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{yoo_congenital_2010,\n\ttitle = {Congenital esophageal stenosis associated with esophageal atresia/tracheoesophageal fistula: clinical and radiologic features},\n\tvolume = {40},\n\tissn = {1432-1998},\n\tshorttitle = {Congenital esophageal stenosis associated with esophageal atresia/tracheoesophageal fistula},\n\tdoi = {10.1007/s00247-010-1603-0},\n\tabstract = {BACKGROUND: Congenital esophageal stenosis (CES) can be associated with esophageal atresia/tracheoesophageal fistula (EA/TEF). Because there are a variety of degrees of obstruction and symptoms of CES, it is frequently difficult to make a pre- and post-operative diagnosis of the distal CES associated with EA/TEF.\nOBJECTIVE: To evaluate the clinical and radiologic features of congenital esophageal stenosis associated with esophageal atresia/tracheoesophageal fistula.\nMATERIALS AND METHODS: We retrospectively reviewed postoperative esophagograms and medical records of 187 children (107 boys, 80 girls) who had primary repair of EA/TEF from 1992 to 2009 at our institution. We evaluated the incidence of CES, clinical findings, radiologic features and management of CES in these children.\nRESULTS: CES was diagnosed in 22 of 187 EA/TEF children (12\\%); one child had double CES lesions, for a total of 23 lesions. Ten of those 22 children (45\\%) had presented with significant symptoms of esophageal obstruction. The diagnosis of CES was delayed in 10 children (45\\%) until 1-10 years of age. On esophagogram, CES (n = 23) was located in the distal esophagus (n = 20, 87\\%) or mid-esophagus (n = 3, 13\\%). The degree of stenosis was severe (n = 6, 26\\%), moderate (n = 10, 43\\%), or mild (n = 7, 30\\%). Eight children, including two with unsuccessful esophageal balloon dilatation of CES, were treated surgically. Histologic examination revealed tracheobronchial remnant (n = 7) or fibromuscular hyperplasia (n = 1). One child with surgically treated CES developed achalasia at the age of 3 years 9 months.\nCONCLUSION: Esophagography after EA/TEF repair should be performed with a high index of suspicion for the presence of distal CES, because the diagnosis and adequate management of CES can often be delayed.},\n\tlanguage = {eng},\n\tnumber = {8},\n\tjournal = {Pediatric Radiology},\n\tauthor = {Yoo, Hye Jin and Kim, Woo Sun and Cheon, Jung-Eun and Yoo, So-Young and Park, Kwi-Won and Jung, Sung-Eun and Shin, Su-Mi and Kim, In-One and Yeon, Kyung Mo},\n\tmonth = aug,\n\tyear = {2010},\n\tpmid = {20221592},\n\tkeywords = {Child, Digestive System Abnormalities, Esophageal Atresia, Esophageal Stenosis, Female, Humans, Longitudinal Studies, Male, Radiography, Retrospective Studies, Treatment Outcome},\n\tpages = {1353--1359},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia.\n \n \n \n\n\n \n Esquibies, A. E.; Zambrano, E.; Ziai, J.; Kesebir, D.; Touloukian, R. J.; Egan, M. E.; Reyes-Múgica, M.; and Bazzy-Asaad, A.\n\n\n \n\n\n\n Pediatric Pulmonology, 45(2): 202–204. February 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{esquibies_pulmonary_2010,\n\ttitle = {Pulmonary squamous cell carcinoma associated with repaired congenital tracheoesophageal fistula and esophageal atresia},\n\tvolume = {45},\n\tissn = {1099-0496},\n\tdoi = {10.1002/ppul.21148},\n\tabstract = {We report a 19-year-old man with pulmonary squamous cell carcinoma (SCC) who had a history of vertebral, anal, cardiac, tracheal, esophageal, renal, and radial limb defects (VACTERL) association and tracheoesophageal fistula (TEF) + esophageal atresia (EA) repair as an infant. Children that undergo TEF + EA repair may have an increased risk for developing cancer as they reach adulthood.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Pediatric Pulmonology},\n\tauthor = {Esquibies, Americo E. and Zambrano, Eduardo and Ziai, James and Kesebir, Deniz and Touloukian, Robert J. and Egan, Marie E. and Reyes-Múgica, Miguel and Bazzy-Asaad, Alia},\n\tmonth = feb,\n\tyear = {2010},\n\tpmid = {20054858},\n\tkeywords = {Abnormalities, Multiple, Carcinoma, Squamous Cell, Esophageal Atresia, Fatal Outcome, Humans, Lung Neoplasms, Male, Postoperative Complications, Risk Factors, Tracheoesophageal Fistula, Treatment Outcome, Young Adult},\n\tpages = {202--204},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Colonic interposition for esophageal replacement in children remains a good choice: 33-year median follow-up of 65 patients.\n \n \n \n\n\n \n Burgos, L.; Barrena, S.; Andrés, A. M.; Martínez, L.; Hernández, F.; Olivares, P.; Lassaletta, L.; and Tovar, J. A.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 45(2): 341–345. February 2010.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{burgos_colonic_2010,\n\ttitle = {Colonic interposition for esophageal replacement in children remains a good choice: 33-year median follow-up of 65 patients},\n\tvolume = {45},\n\tissn = {1531-5037},\n\tshorttitle = {Colonic interposition for esophageal replacement in children remains a good choice},\n\tdoi = {10.1016/j.jpedsurg.2009.10.065},\n\tabstract = {INTRODUCTION: Gastric pull-up has become the predominant technique for esophageal replacement because of allegedly deficient results of colon grafts. This retrospective study examines the long-term results in a large series of colonic interpositions.\nPATIENTS AND METHOD: One hundred six children (median, 2.9 years; range, 0.32-15 years) had their esophagus replaced between 1965 and 2008, of which 96 had colon grafts. Those survivors who were 18 years and older were contacted and, if willing, interviewed, examined, and had their functional ability rated using the Karnofsky index.\nRESULTS: Ninety-six children had undergone a colon graft, and of these, 9 (9.3\\%) died. There were 65 long-term survivors whose indications for surgery included caustic injury (n = 32), failed tracheoesophageal fistula repair (n = 16), pure esophageal atresia (n = 14), and others (n = 3). The graft was either retrosternal (n = 49) or mediastinal (n = 16 patients). Twelve patients were unavailable for long-term assessment. After a median follow-up of 33.3 (11-41) years, 23 (43\\%) of 53 individuals experienced mild symptoms of reflux; scoliosis, 12 (22\\%) of 53, and/or other complications, 15 (27\\%) of 53 required further surgery. Thirty-two patients (60\\%) with Karnofsky indexes of 80\\% or higher felt healthy, 19 (36\\%) had mild life-style limitations (index, 40\\%-80\\%), and 2 had indexes less than 40\\%. Most patients live normal lives.\nCONCLUSIONS: Colon conduits restored gastrointestinal continuity with limited mortality and considerable morbidity but good functional outcome and health perception in the long-term. Our study suggests that colon grafts are no worse than gastric pull-ups in the long-term.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Burgos, Laura and Barrena, Saturnino and Andrés, Ane M. and Martínez, Leopoldo and Hernández, Francisco and Olivares, Pedro and Lassaletta, Luis and Tovar, Juan A.},\n\tmonth = feb,\n\tyear = {2010},\n\tpmid = {20152348},\n\tkeywords = {Adult, Anastomosis, Surgical, Child, Child, Preschool, Colon, Digestive System Surgical Procedures, Disease-Free Survival, Esophageal Atresia, Esophagoplasty, Esophagus, Female, Humans, Infant, Karnofsky Performance Status, Longitudinal Studies, Male, Quality of Life, Retrospective Studies, Trachea, Tracheoesophageal Fistula, Treatment Outcome, Young Adult},\n\tpages = {341--345},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Prolonged enteral feeding is often required to avoid long-term nutritional and metabolic complications after esophagogastric dissociation.\n \n \n \n \n\n\n \n Madre, C.; Serhal, L.; Michaud, L.; Bonnevalle, M.; de Lagausie, P.; Gottrand, F.; Bonnard, A.; and Hugot, J.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 50(3): 280–286. March 2010.\n \n\n\n\n
\n\n\n\n \n \n $\"Prolonged$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{madre_prolonged_2010,\n\ttitle = {Prolonged enteral feeding is often required to avoid long-term nutritional and metabolic complications after esophagogastric dissociation},\n\tvolume = {50},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/19668010/},\n\tdoi = {10.1097/MPG.0b013e3181a159fa},\n\tabstract = {BACKGROUND: Total esophagogastric dissociation (TED) was first described in 1997 by Bianchi as a new surgical procedure to treat severe gastroesophageal reflux disease (GERD) in children with neurological impairment. Recently, TED has been proposed in other conditions, such as esophageal atresia, esotracheal cleft, or caustic esophageal lesions. Although the long-term results in terms of GERD control have been previously reported, those regarding the nutritional and metabolic status have never been documented.\nPATIENTS AND METHODS: All patients without neurological impairment with TED between 1999 and 2004 at Robert Debre Hospital and Jeanne de Flandre Hospital, France, were prospectively investigated, paying particular attention to their metabolic and nutritional status (blood concentration of iron and vitamins A, D, E, and B12; lipid malabsorption; and hyperglycemia test) and growth.\nRESULTS: Seventeen children underwent TED. Six received primary procedures, whereas 11 were operated on because of severe respiratory diseases or failure to thrive. The mean follow-up was 6 years (range 3-8 years). Two children died (12\\%). Seven children were weaned from enteral nutrition support, but 5 of them had failure to thrive, steatorrhea, and/or malabsorption of vitamin B12 and/or fat-soluble vitamins. Eight patients had dumping syndrome, which was symptomatic in 6 cases.\nCONCLUSIONS: TED is an effective procedure for treatment of GERD. However, nutritional and metabolic complications including dumping syndrome and chronic digestive malabsorption are frequent after TED, especially after enteral nutrition weaning. A long-term follow-up of these patients is thus necessary and prolonged enteral nutrition support is recommended.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Madre, Chrystèle and Serhal, Lydia and Michaud, Laurent and Bonnevalle, Michel and de Lagausie, Pascal and Gottrand, Frédéric and Bonnard, Arnaud and Hugot, Jean-Pierre},\n\tmonth = mar,\n\tyear = {2010},\n\tpmid = {19668010},\n\tkeywords = {Adolescent, Avitaminosis, Child, Child, Preschool, Dumping Syndrome, Enteral Nutrition, Esophagus, Failure to Thrive, Female, Gastroesophageal Reflux, Humans, Infant, Infant, Newborn, Malabsorption Syndromes, Male, Outcome Assessment, Health Care, Postoperative Complications, Respiratory Tract Diseases, Steatorrhea},\n\tpages = {280--286},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Anastomotic stricture after surgical repair of esophageal atresia: frequency, risk factors, and efficacy of esophageal bougie dilatations.\n \n \n \n \n\n\n \n Serhal, L.; Gottrand, F.; Sfeir, R.; Guimber, D.; Devos, P.; Bonnevalle, M.; Storme, L.; Turck, D.; and Michaud, L.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 45(7): 1459–1462. July 2010.\n \n\n\n\n
\n\n\n\n \n \n $\"Anastomotic$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{serhal_anastomotic_2010,\n\ttitle = {Anastomotic stricture after surgical repair of esophageal atresia: frequency, risk factors, and efficacy of esophageal bougie dilatations},\n\tvolume = {45},\n\tissn = {1531-5037},\n\tshorttitle = {Anastomotic stricture after surgical repair of esophageal atresia},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/20638524/},\n\tdoi = {10.1016/j.jpedsurg.2009.11.002},\n\tabstract = {AIMS: The aim of this study was to evaluate the frequency and risk factors of postoperative anastomotic stricture, and the efficacy and complications of esophageal bougie dilatations for symptomatic anastomotic stricture in a population of children with esophageal atresia.\nPATIENTS AND METHODS: The medical records of 62 children operated on for esophageal atresia type III (Ladd and Gross) over a 5-year period were retrospectively reviewed.\nRESULTS: Anastomotic stricture developed in 23 (37\\%) of patients. Anastomotic tension during primary repair of esophageal atresia was associated with subsequent stricture formation (P {\\textless} .05). Patients required esophageal dilation at a mean age of 149 days (range, 30-600 days). Stricture resolution occurred after a mean of 3.2 dilatations per patient (range, 1-7). Dilation was successful in 87\\% of patients. Three patients continued to present mild (n = 1) to severe (n = 2) dysphagia, mainly related to esophageal dysmotility. No complications were observed during or after the dilatation sessions.\nCONCLUSIONS: Anastomotic stricture, secondary to the surgical treatment of esophageal atresia, remains a frequent complication in patients with esophageal atresia. Esophageal dilation with Savary-Gilliard bougies is a safe and effective procedure in the management of strictures.},\n\tlanguage = {eng},\n\tnumber = {7},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Serhal, Lydia and Gottrand, Frédéric and Sfeir, Rony and Guimber, Dominique and Devos, Patrick and Bonnevalle, Michel and Storme, Laurent and Turck, Dominique and Michaud, Laurent},\n\tmonth = jul,\n\tyear = {2010},\n\tpmid = {20638524},\n\tkeywords = {Anastomosis, Surgical, Dilatation, Esophageal Atresia, Esophageal Stenosis, Esophagoscopy, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Multivariate Analysis, Retrospective Studies, Risk Factors},\n\tpages = {1459--1462},\n}\n\n\n\n

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\n \n 2009\n \n \n (4)\n \n \n

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\n \n \n

\n \n\n \n \n \n \n \n \n Retrograde dilatation via gastrostomy of a proximal esophagoileal anastomotic stricture in an infant with esophageal atresia.\n \n \n \n \n\n\n \n Macher, E.; Michaud, L.; Guimber, D.; Bonnevalle, M.; Turck, D.; and Gottrand, F.\n\n\n \n\n\n\n Endoscopy, 41 Suppl 2: E10. 2009.\n \n\n\n\n
\n\n\n\n \n \n $\"Retrograde$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{macher_retrograde_2009,\n\ttitle = {Retrograde dilatation via gastrostomy of a proximal esophagoileal anastomotic stricture in an infant with esophageal atresia},\n\tvolume = {41 Suppl 2},\n\tissn = {1438-8812},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/19668010/},\n\tdoi = {10.1055/s-2008-1077649},\n\tlanguage = {eng},\n\tjournal = {Endoscopy},\n\tauthor = {Macher, E. and Michaud, L. and Guimber, D. and Bonnevalle, M. and Turck, D. and Gottrand, F.},\n\tyear = {2009},\n\tpmid = {19177290},\n\tkeywords = {Anastomosis, Surgical, Catheterization, Constriction, Pathologic, Esophageal Atresia, Esophageal Stenosis, Esophagus, Follow-Up Studies, Gastrostomy, Humans, Ileum, Infant, Male, Risk Assessment, Treatment Outcome},\n\tpages = {E10},\n}\n\n\n\n\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Mental health and psychosocial functioning in adolescents with esophageal atresia.\n \n \n \n\n\n \n Faugli, A.; Bjørnland, K.; Emblem, R.; Nøvik, T. S.; and Diseth, T. H.\n\n\n \n\n\n\n Journal of Pediatric Surgery, 44(4): 729–737. April 2009.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{faugli_mental_2009,\n\ttitle = {Mental health and psychosocial functioning in adolescents with esophageal atresia},\n\tvolume = {44},\n\tissn = {1531-5037},\n\tdoi = {10.1016/j.jpedsurg.2008.09.027},\n\tabstract = {PURPOSE: We examined mental health and psychosocial functioning in adolescents with esophageal atresia (EA) and searched for predictors of impaired outcome.\nMETHODS: The study group comprised 21 adolescents with EA and 1 or both parents. A comparison group comprised 36 adolescents from the general population. Mental health, self-esteem, psychosocial functioning, and parental/family functioning were assessed by standardized questionnaires and semistructured interviews. Physical health was assessed by growth and clinical symptoms.\nRESULTS: Mental health and psychosocial functioning did not differ from the comparison group. Seven of 21 EA adolescents had special education. Dilatations of esophagus, birth weight, well-being, and maternal psychological distress were prognostic factors predicting mental health. Height, birth weight, well-being, dissociative symptoms, and family strain were prognostic factors predicting psychosocial functioning.\nCONCLUSION: Adolescents with EA adjusted well, and mental health and psychosocial functioning did not differ from controls. Dilatations of esophagus and birth weight were significant predictors of mental health and psychosocial functioning.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Surgery},\n\tauthor = {Faugli, Anne and Bjørnland, Kristin and Emblem, Ragnhild and Nøvik, Torunn S. and Diseth, Trond H.},\n\tmonth = apr,\n\tyear = {2009},\n\tpmid = {19361632},\n\tkeywords = {Adaptation, Physiological, Adaptation, Psychological, Adolescent, Esophageal Atresia, Female, Humans, Interpersonal Relations, Male, Mental Health, Norway, Parent-Child Relations, Psychology, Quality of Life, Reference Values, Retrospective Studies, Risk Assessment, Self Concept, Sex Factors, Sickness Impact Profile, Statistics, Nonparametric, Surveys and Questionnaires},\n\tpages = {729--737},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n Outcome of esophageal atresia beyond childhood.\n \n \n \n\n\n \n Rintala, R. J.; Sistonen, S.; and Pakarinen, M. P.\n\n\n \n\n\n\n Seminars in Pediatric Surgery, 18(1): 50–56. February 2009.\n \n\n\n\n
\n\n\n\n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{rintala_outcome_2009,\n\ttitle = {Outcome of esophageal atresia beyond childhood},\n\tvolume = {18},\n\tissn = {1055-8586},\n\tdoi = {10.1053/j.sempedsurg.2008.10.010},\n\tabstract = {Survivors of esophageal atresia are reaching their adulthood in large numbers for the first time enabling assessment of true long-term outcome among this group of patients. This review summarizes the current knowledge on the subject focusing on late symptoms and complications, esophageal pathology and pulmonary function. Relationships between esophageal dysmotility, gastroesophageal reflux, esophagitis and epithelial metaplastic changes including esophageal cancer are outlined. In addition to pertinent literature, institutional experience, and follow-up of patients with esophageal atresia for more than 60 years is included.},\n\tlanguage = {eng},\n\tnumber = {1},\n\tjournal = {Seminars in Pediatric Surgery},\n\tauthor = {Rintala, R. J. and Sistonen, S. and Pakarinen, M. P.},\n\tmonth = feb,\n\tyear = {2009},\n\tpmid = {19103423},\n\tkeywords = {Adult, Age Factors, Anastomosis, Surgical, Esophageal Atresia, Esophagus, Humans, Survival Analysis, Thoracotomy, Time Factors, Treatment Outcome},\n\tpages = {50--56},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Influence of esophageal pH recording on physical activity in children.\n \n \n \n \n\n\n \n Michaud, L.; Troadec, F.; Béghin, L.; El Rifai, N.; Guimber, D.; Turck, D.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 48(4): 426–430. April 2009.\n \n\n\n\n
\n\n\n\n \n \n $\"Influence$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{michaud_influence_2009,\n\ttitle = {Influence of esophageal {pH} recording on physical activity in children},\n\tvolume = {48},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21242548/},\n\tdoi = {10.1097/mpg.0b013e31817f2827},\n\tabstract = {OBJECTIVES: Twenty-four-hour pH-metry represents the gold standard for the diagnosis of gastroesophageal reflux. Ambulatory esophageal pH recording provides a better reflection of occurrences under normal domestic living conditions, but it may influence physical activity. The aim of this study was to assess the influence of ambulatory esophageal pH recording on physical activity in children.\nPATIENTS AND METHODS: This prospective study included 22 patients (18 boys, 4 girls) 3 to 15 years old (mean age 6.9 +/- 2.3 years) who had been referred for ambulatory pH-metry. The 24-hour physical activity was measured twice in each child using a triaxial accelerometer 1 week before or after pH-metry and during pH-metry. Levels of intensity of physical activity (low: sedentary activities; moderate: walking; high: intense activities such as jumping, running, and sport) were compared by the paired nonparametric Wilcoxon test.\nRESULTS: Physical activity was 53\\% lower during 24-hour pH-metry than when it was not present (P {\\textless} 0.0005). The duration of low-level physical activity was longer during pH-metry (84\\% vs 73\\%; P {\\textless} 0.01). The duration of moderate-intensity and high-intensity physical activity was shorter during pH-metry (16\\% vs 24\\% and 0.2\\% vs 2.2\\%, respectively; P {\\textless} 0.005 and P {\\textless} 0.0001).\nCONCLUSIONS: Ambulatory 24-hour esophageal pH recording substantially decreases physical activity, mainly high-level physical activity. Whether such changes in activity decrease the sensitivity of pH-metry and lead to false negative results in some children remains to be assessed.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Michaud, Laurent and Troadec, Françoise and Béghin, Laurent and El Rifai, Nahida and Guimber, Dominique and Turck, Dominique and Gottrand, Frédéric},\n\tmonth = apr,\n\tyear = {2009},\n\tpmid = {19330930},\n\tkeywords = {Activities of Daily Living, Adolescent, Child, Child, Preschool, Esophageal pH Monitoring, Female, Gastroesophageal Reflux, Humans, Male, Monitoring, Ambulatory, Motor Activity, Prospective Studies},\n\tpages = {426--430},\n}\n\n\n\n

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\n \n 2008\n \n \n (2)\n \n \n

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\n \n \n

\n \n\n \n \n \n \n \n \n Prenatal and early postnatal morphogenesis and growth of human laryngotracheal structures.\n \n \n \n \n\n\n \n Fayoux, P.; Marciniak, B.; Devisme, L.; and Storme, L.\n\n\n \n\n\n\n Journal of Anatomy, 213(2): 86–92. August 2008.\n \n\n\n\n
\n\n\n\n \n \n $\"Prenatal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{fayoux_prenatal_2008,\n\ttitle = {Prenatal and early postnatal morphogenesis and growth of human laryngotracheal structures},\n\tvolume = {213},\n\tissn = {0021-8782},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/19172727/},\n\tdoi = {10.1111/j.1469-7580.2008.00935.x},\n\tabstract = {Advances in neonatal medicine have resulted in increased care of fetal and neonatal airways. These advances have required an exhaustive knowledge of fetal airway anatomy and development. The aim of this study was to determine the anatomical development of laryngotracheal structures during the fetal and immediate postnatal period and to correlate these observations with other fetal biometric parameters to estimate developmental particularities of the fetal airway. An anatomical prospective study was based on examination of larynx and trachea from 300 routine autopsies of fetuses and infants, free of malformation and never intubated. Anatomical measurements of cricoid cartilage, thyroid cartilage, glottis, arytenoid cartilage and trachea were performed using a precision calliper and precision divider. Statistical analysis was performed to represent the growth of anatomical structures and to evaluate the correlation with biometric data. Raw data and 10th and 90th percentile curves were fitted satisfactorily with a linear model for gestational age. A linear relationship between laryngotracheal measurement and body weight and height was observed except for glottis length, interarytenoid distance and anterior cricoid height. The diameter of the cricoid lumen was significantly less than that of the trachea and glottis lumen. A sexual dysmorphism was noted for thyroid cartilage measurements and interarytenoid distance, with measurements significantly smaller in females. This study reports the anatomical development of normal laryngotracheal structures during the fetal period. Despite the fact that this study was performed during postmortem examination, these observations can be useful to develop criteria, materials and surgical procedures adapted to fetal and neonatal airways as well as for the purposes of early diagnosis and management of laryngotracheal malformations.},\n\tlanguage = {eng},\n\tnumber = {2},\n\tjournal = {Journal of Anatomy},\n\tauthor = {Fayoux, Pierre and Marciniak, Bruno and Devisme, Louise and Storme, Laurent},\n\tmonth = aug,\n\tyear = {2008},\n\tpmid = {19172727},\n\tpmcid = {PMC2526109},\n\tkeywords = {Anthropometry, Female, Fetal Development, Gestational Age, Humans, Infant, Newborn, Laryngeal Cartilages, Male, Morphogenesis, Prospective Studies, Sex Characteristics, Trachea},\n\tpages = {86--92},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Long-term outcome of colon interposition after esophagectomy in children.\n \n \n \n \n\n\n \n Coopman, S.; Michaud, L.; Halna-Tamine, M.; Bonnevalle, M.; Bourgois, B.; Turck, D.; and Gottrand, F.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 47(4): 458–462. October 2008.\n \n\n\n\n
\n\n\n\n \n \n $\"Long-term$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{coopman_long-term_2008,\n\ttitle = {Long-term outcome of colon interposition after esophagectomy in children},\n\tvolume = {47},\n\tissn = {1536-4801},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/18852638/},\n\tdoi = {10.1097/MPG.0b013e31815ce55c},\n\tabstract = {BACKGROUND AND OBJECTIVES: Tissues derived from the colon, stomach, and jejunum have been used to replace the esophagus in childhood to cure esophageal atresia or stricture secondary to gastroesophageal reflux or the ingestion of corrosive agents. The outcome in adulthood of colon interposition performed at an early age has yet to be satisfactorily assessed. The aim of this single-center retrospective study was to evaluate the long-term nutritional, digestive, and respiratory outcome of all patients (n = 32) who underwent colon interposition during childhood in our hospital (1970-2001).\nPATIENTS AND METHODS: Medical records of these subjects were reviewed and their nutritional (weight, height, 24-hour food diary), digestive (questionnaire), and pulmonary function status evaluated.\nRESULTS: Of the patients, 17 had esophageal atresia (7 males, median age at surgery 11 months, range 0.5-61) and 15 had ingested corrosive substances (10 males, median age at surgery 50 months, range 22-113). Complications occurred less than 1 year postoperatively in 53\\% and long-term complications (occurring {\\textgreater}1 year after surgery) in 84\\%. Long-term complications were common: digestive symptoms were found in 85\\% (most frequently observed during the first 5 years of follow-up), abnormal lung function in 7 (58\\%) of those tested (n = 12), feeding difficulties in 50\\%, scoliosis in 35\\%, and nutritional complications in 25\\%.\nCONCLUSIONS: Our study showed a high rate of sequelae following esophageal replacement. This highlights the need for multidisciplinary long-term follow-up into adulthood, and research into alternatives to colon interposition as treatment for esophageal strictures.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Coopman, S. and Michaud, L. and Halna-Tamine, M. and Bonnevalle, M. and Bourgois, B. and Turck, D. and Gottrand, F.},\n\tmonth = oct,\n\tyear = {2008},\n\tpmid = {18852638},\n\tkeywords = {Adolescent, Caustics, Child, Child, Preschool, Colon, Esophageal Atresia, Esophageal Stenosis, Esophagectomy, Esophagus, Female, Follow-Up Studies, France, Humans, Infant, Male, Nutritional Status, Postoperative Complications, Retrospective Studies, Time Factors, Treatment Outcome},\n\tpages = {458--462},\n}\n\n\n\n

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\n \n 2006\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Mitomycin C: an alternative conservative treatment for refractory esophageal stricture in children?.\n \n \n \n \n\n\n \n Uhlen, S.; Fayoux, P.; Vachin, F.; Guimber, D.; Gottrand, F.; Turck, D.; and Michaud, L.\n\n\n \n\n\n\n Endoscopy, 38(4): 404–407. April 2006.\n \n\n\n\n
\n\n\n\n \n \n $\"Mitomycin$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{uhlen_mitomycin_2006,\n\ttitle = {Mitomycin {C}: an alternative conservative treatment for refractory esophageal stricture in children?},\n\tvolume = {38},\n\tissn = {0013-726X},\n\tshorttitle = {Mitomycin {C}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/16586239/},\n\tdoi = {10.1055/s-2006-925054},\n\tabstract = {BACKGROUND AND STUDY AIMS: Mitomycin C is an antiproliferative agent that has been used successfully as an adjunct treatment in ophthalmological procedures, in the management of laryngeal and tracheal stenosis, and more recently to prevent the recurrence of caustic esophageal strictures in children. The aim of this study was to assess the efficacy and safety of local application of mitomycin C to refractory esophageal strictures in children.\nPATIENTS AND METHODS: We performed a preliminary prospective study of local application of mitomycin C in four children, aged between 1 year and 6 years, who had refractory esophageal strictures. Two of the children presented with strictures caused by caustic ingestion and the other two children had anastomotic strictures following surgical repair of congenital esophageal atresia. The patients had required between four and ten esophageal dilations over a 5-24-month period before mitomycin C application. After an endoscopic dilation, mitomycin C was applied onto the dilation wound using a rigid endoscope.\nRESULTS: No complications were observed after the procedure. One child required a second application of mitomycin C 2 weeks after the first application because of recurrence of dysphagia. All the children remained asymptomatic and none of them required further dilation over a mean follow-up period of 24 months. Radiological control examinations revealed that there was no recurrence of the esophageal strictures and esophageal biopsies performed during follow-up showed no signs of dysplasia.\nCONCLUSIONS: Local application of mitomycin C is a potential alternative to iterative dilations, surgery, or stent placement for the treatment of refractory esophageal strictures in children. However, prospective, long-term assessment of outcomes is needed before any definitive conclusion can be drawn about the usefulness of mitomycin C in these patients.},\n\tlanguage = {eng},\n\tnumber = {4},\n\tjournal = {Endoscopy},\n\tauthor = {Uhlen, S. and Fayoux, P. and Vachin, F. and Guimber, D. and Gottrand, F. and Turck, D. and Michaud, L.},\n\tmonth = apr,\n\tyear = {2006},\n\tpmid = {16586239},\n\tkeywords = {Administration, Topical, Antibiotics, Antineoplastic, Article original, Dilatation, Esophageal Stenosis, Follow-Up Studies, Mitomycin, Retrospective Studies, Treatment Outcome},\n\tpages = {404--407},\n}\n\n\n\n

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\n \n 1999\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Nitrous oxide sedation in pediatric patients undergoing gastrointestinal endoscopy.\n \n \n \n \n\n\n \n Michaud, L.; Gottrand, F.; Ganga-Zandzou, P. S.; Ouali, M.; Vetter-Laffargue, A.; Lambilliotte, A.; Dalmas, S.; and Turck, D.\n\n\n \n\n\n\n Journal of Pediatric Gastroenterology and Nutrition, 28(3): 310–314. March 1999.\n \n\n\n\n
\n\n\n\n \n \n $\"Nitrous$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n \n \n \n \n \n \n \n \n\n\n\n

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@article{michaud_nitrous_1999,\n\ttitle = {Nitrous oxide sedation in pediatric patients undergoing gastrointestinal endoscopy},\n\tvolume = {28},\n\tissn = {0277-2116},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/10067734/},\n\tdoi = {10.1097/00005176-199903000-00018},\n\tabstract = {BACKGROUND: The ideal medication to administer to children before gastrointestinal endoscopy procedures has yet to be found. The efficacy of using inhaled nitrous oxide during endoscopy in children was assessed in a pilot study.\nMETHODS: Patients aged 5 to 17 years, referred to our hospital for diagnostic upper gastrointestinal endoscopy or rectosigmoidoscopy procedures, were eligible for enrollment in this study. All received 50\\% nitrous oxide in oxygen (Entonox; AGA, Rueil-Malmaison, France) before endoscopy and some of them again during endoscopy. The pediatric endoscopist and the nurse performing the procedure were separately asked to rate cooperation, emotional state, drowsiness and overall efficacy of sedation. Oxygen saturation and adverse effects were recorded throughout the procedure. After endoscopy, children scored their degree of pain during the procedures on a visual analog scale (0, no pain; 100, agony) and on a body outline (projective method). Any adverse effects were noted.\nRESULTS: Thirty-seven patients were enrolled in the study. Thirty patients underwent diagnostic upper gastrointestinal endoscopy and seven diagnostic rectosigmoidoscopy. The median time from administration of nitrous oxide until insertion of the endoscope was 5 minutes (range, 3-8 minutes). Good or excellent efficacy of the sedation was noted in 92\\% of children by the endoscopist and in 89\\% by the nurses. Good or excellent cooperation was noted in 92\\% of the children by the endoscopist and in 78\\% by the nurses. The children's pain score on the visual analog scale ranged from 5 to 100 (median, 20) for upper gastrointestinal endoscopy and from 0 to 30 (median, 0) for rectosigmoidoscopy. The time of discharge after endoscopy, defined as the time elapsed between the end of the endoscopy and discharge from the endoscopy suite, varied from 1 to 7 minutes (median, 1.5 minutes).\nCONCLUSION: Entonox provides rapid and effective analgesia without heavy sedation, leads to adequate relaxation and cooperation, and facilitates quick and efficient endoscopy. The effect of Entonox was of short duration, allowing the children to leave the endoscopy unit without need for a long recovery period. The adverse effects of Entonox appeared to be minor, and their duration was always brief. Nitrous oxide-oxygen inhalation may provide a valuable alternative to conventional sedation regimens during gastrointestinal endoscopy in children, but randomized and prospective studies comparing nitrous oxide sedation and conventional sedation regimens are necessary.},\n\tlanguage = {eng},\n\tnumber = {3},\n\tjournal = {Journal of Pediatric Gastroenterology and Nutrition},\n\tauthor = {Michaud, L. and Gottrand, F. and Ganga-Zandzou, P. S. and Ouali, M. and Vetter-Laffargue, A. and Lambilliotte, A. and Dalmas, S. and Turck, D.},\n\tmonth = mar,\n\tyear = {1999},\n\tpmid = {10067734},\n\tkeywords = {Anesthetics, Inhalation, Original article, pH-monitoring},\n\tpages = {310--314},\n}\n\n\n\n

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\n BACKGROUND: The ideal medication to administer to children before gastrointestinal endoscopy procedures has yet to be found. The efficacy of using inhaled nitrous oxide during endoscopy in children was assessed in a pilot study. METHODS: Patients aged 5 to 17 years, referred to our hospital for diagnostic upper gastrointestinal endoscopy or rectosigmoidoscopy procedures, were eligible for enrollment in this study. All received 50% nitrous oxide in oxygen (Entonox; AGA, Rueil-Malmaison, France) before endoscopy and some of them again during endoscopy. The pediatric endoscopist and the nurse performing the procedure were separately asked to rate cooperation, emotional state, drowsiness and overall efficacy of sedation. Oxygen saturation and adverse effects were recorded throughout the procedure. After endoscopy, children scored their degree of pain during the procedures on a visual analog scale (0, no pain; 100, agony) and on a body outline (projective method). Any adverse effects were noted. RESULTS: Thirty-seven patients were enrolled in the study. Thirty patients underwent diagnostic upper gastrointestinal endoscopy and seven diagnostic rectosigmoidoscopy. The median time from administration of nitrous oxide until insertion of the endoscope was 5 minutes (range, 3-8 minutes). Good or excellent efficacy of the sedation was noted in 92% of children by the endoscopist and in 89% by the nurses. Good or excellent cooperation was noted in 92% of the children by the endoscopist and in 78% by the nurses. The children's pain score on the visual analog scale ranged from 5 to 100 (median, 20) for upper gastrointestinal endoscopy and from 0 to 30 (median, 0) for rectosigmoidoscopy. The time of discharge after endoscopy, defined as the time elapsed between the end of the endoscopy and discharge from the endoscopy suite, varied from 1 to 7 minutes (median, 1.5 minutes). CONCLUSION: Entonox provides rapid and effective analgesia without heavy sedation, leads to adequate relaxation and cooperation, and facilitates quick and efficient endoscopy. The effect of Entonox was of short duration, allowing the children to leave the endoscopy unit without need for a long recovery period. The adverse effects of Entonox appeared to be minor, and their duration was always brief. Nitrous oxide-oxygen inhalation may provide a valuable alternative to conventional sedation regimens during gastrointestinal endoscopy in children, but randomized and prospective studies comparing nitrous oxide sedation and conventional sedation regimens are necessary.\n

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\n \n\n \n \n \n \n \n \n Outcomes of treatment of childhood achalasia - PubMed.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"Outcomes$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_outcomes_nodate,\n\ttitle = {Outcomes of treatment of childhood achalasia - {PubMed}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/20620315/},\n\turldate = {2025-01-09},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Postoperative appearances of esophageal atresia repair: retrospective study of 210 patients with review of literature - what the radiologist should know - PubMed.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"Postoperative$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_postoperative_nodate,\n\ttitle = {Postoperative appearances of esophageal atresia repair: retrospective study of 210 patients with review of literature - what the radiologist should know - {PubMed}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23117198/},\n\turldate = {2025-01-09},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Peut-on diagnostiquer l’atrésie de l’œsophage en prénatal ? \\textbar Revue de médecine périnatale.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
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@misc{noauthor_peut-diagnostiquer_nodate,\n\ttitle = {Peut-on diagnostiquer l’atrésie de l’œsophage en prénatal ? {\\textbar} {Revue} de médecine périnatale},\n\turl = {https://link.springer.com/article/10.1007/s12611-012-0189-1},\n\turldate = {2025-01-09},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Long-term outcome of children with oesophageal atresia type III - PubMed.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"Long-term$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_long-term_nodate,\n\ttitle = {Long-term outcome of children with oesophageal atresia type {III} - {PubMed}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/22753768/},\n\turldate = {2025-01-09},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Terminal 4q deletion and 8q duplication in a patient with CHARGE-like features - PubMed.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"Terminal$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_terminal_nodate,\n\ttitle = {Terminal 4q deletion and 8q duplication in a patient with {CHARGE}-like features - {PubMed}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/21094707/},\n\turldate = {2025-01-09},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Contemporary management and outcomes for infants born with oesophageal atresia - PubMed.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"Contemporary$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_contemporary_nodate,\n\ttitle = {Contemporary management and outcomes for infants born with oesophageal atresia - {PubMed}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23334932/},\n\turldate = {2025-01-09},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n Topical mitomycin C application is effective in management of localized caustic esophageal stricture: a double-blinded, randomized, placebo-controlled trial - PubMed.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"Topical$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_topical_nodate,\n\ttitle = {Topical mitomycin {C} application is effective in management of localized caustic esophageal stricture: a double-blinded, randomized, placebo-controlled trial - {PubMed}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/23895984/},\n\turldate = {2025-01-09},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Congenital esophageal stenosis associated with esophageal atresia - PubMed.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"Congenital$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_congenital_nodate,\n\ttitle = {Congenital esophageal stenosis associated with esophageal atresia - {PubMed}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/24446921/},\n\turldate = {2025-01-09},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n Endoscopic incision plus esophageal stenting for refractory esophageal stricture in children - PubMed.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"Endoscopic$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_endoscopic_nodate,\n\ttitle = {Endoscopic incision plus esophageal stenting for refractory esophageal stricture in children - {PubMed}},\n\turl = {https://pubmed.ncbi.nlm.nih.gov/24676814/},\n\turldate = {2025-01-09},\n}\n\n\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n DOZ047.55: Midterm follow-up of long-gap esophageal atresia national cohort: study of feeding difficulties and morbidity \\textbar Diseases of the Esophagus \\textbar Oxford Academic.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
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@misc{noauthor_doz04755_nodate,\n\ttitle = {{DOZ047}.55: {Midterm} follow-up of long-gap esophageal atresia national cohort: study of feeding difficulties and morbidity {\\textbar} {Diseases} of the {Esophagus} {\\textbar} {Oxford} {Academic}},\n\turl = {https://academic.oup.com/dote/article/32/Supplement_1/doz047.55/5518533?login=true},\n\turldate = {2024-08-21},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n DOZ047.39: Respiratory morbidity at the age of one year in children with esophageal atresia: data from the French National Esophageal Atresia Register \\textbar Diseases of the Esophagus \\textbar Oxford Academic.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"DOZ047.39:$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n \n \n 1 download\n \n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_doz04739_nodate,\n\ttitle = {{DOZ047}.39: {Respiratory} morbidity at the age of one year in children with esophageal atresia: data from the {French} {National} {Esophageal} {Atresia} {Register} {\\textbar} {Diseases} of the {Esophagus} {\\textbar} {Oxford} {Academic}},\n\turl = {https://academic.oup.com/dote/article/32/Supplement_1/doz047.39/5518450?login=true},\n\turldate = {2024-08-21},\n}\n\n\n\n

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\n \n\n \n \n \n \n \n \n DOZ047.35: Early parental adjustment in esophageal atresia and other rare abdominothoracic malformations \\textbar Diseases of the Esophagus \\textbar Oxford Academic.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n \n \n\n\n\n
\n\n\n\n \n \n $\"DOZ047.35:$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@misc{noauthor_doz04735_nodate,\n\ttitle = {{DOZ047}.35: {Early} parental adjustment in esophageal atresia and other rare abdominothoracic malformations {\\textbar} {Diseases} of the {Esophagus} {\\textbar} {Oxford} {Academic}},\n\turl = {https://academic.oup.com/dote/article/32/Supplement_1/doz047.35/5518529?login=true},\n\turldate = {2024-08-21},\n}\n\n\n\n

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