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\n\n \n \n \n \n \n Radiation-free cochlear implant position estimation in pediatric patients using impedance telemetry.\n \n \n \n\n\n \n Veloso de Oliveira, J.; Rosenkranz, U.; Schraivogel, S.; Weiss, N. M.; Caversaccio, M; Hedderich, D.; and Wimmer, W.\n\n\n \n\n\n\n
BMC Pediatrics (in print). 2025.\n
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@article{veloso_de_oliveira_radiation-free_2025,\n\ttitle = {Radiation-free cochlear implant position estimation in pediatric patients using impedance telemetry},\n\tjournal = {BMC Pediatrics (in print)},\n\tauthor = {Veloso de Oliveira, Julia and Rosenkranz, Ulrike and Schraivogel, Stephan and Weiss, Nora M. and Caversaccio, M and Hedderich, Dennis and Wimmer, Wilhelm},\n\tyear = {2025},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Linking brain activation to clinical outcomes: an fNIRS study in cochlear implant users and normal hearing individuals.\n \n \n \n \n\n\n \n Bálint, A.; Wimmer, W.; Rummel, C.; Caversaccio, M.; and Weder, S.\n\n\n \n\n\n\n
Neurophotonics, 13(S1). September 2025.\n
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@article{balint_linking_2025,\n\ttitle = {Linking brain activation to clinical outcomes: an {fNIRS} study in cochlear implant users and normal hearing individuals},\n\tvolume = {13},\n\tissn = {2329-423X},\n\tshorttitle = {Linking brain activation to clinical outcomes},\n\turl = {https://www.spiedigitallibrary.org/journals/neurophotonics/volume-13/issue-S1/S13004/Linking-brain-activation-to-clinical-outcomes--an-fNIRS-study/10.1117/1.NPh.13.S1.S13004.full},\n\tdoi = {10.1117/1.NPh.13.S1.S13004},\n\tnumber = {S1},\n\turldate = {2025-09-12},\n\tjournal = {Neurophotonics},\n\tauthor = {Bálint, András and Wimmer, Wilhelm and Rummel, Christian and Caversaccio, Marco and Weder, Stefan},\n\tmonth = sep,\n\tyear = {2025},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Comprehensive decomposition of cochlear implant electrode impedances.\n \n \n \n \n\n\n \n Veloso De Oliveira, J.; Weiss, N. M.; and Wimmer, W.\n\n\n \n\n\n\n
Hearing Research, 466: 109348. October 2025.\n
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@article{veloso_de_oliveira_comprehensive_2025,\n\ttitle = {Comprehensive decomposition of cochlear implant electrode impedances},\n\tvolume = {466},\n\tissn = {03785955},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0378595525001662},\n\tdoi = {10.1016/j.heares.2025.109348},\n\tlanguage = {en},\n\turldate = {2025-07-25},\n\tjournal = {Hearing Research},\n\tauthor = {Veloso De Oliveira, Julia and Weiss, Nora M. and Wimmer, Wilhelm},\n\tmonth = oct,\n\tyear = {2025},\n\tpages = {109348},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Impedance-based tissue response modeling for the prediction of hearing preservation after cochlear implantation.\n \n \n \n \n\n\n \n Andonie, R.; Caversaccio, M.; Weder, S.; and Wimmer, W.\n\n\n \n\n\n\n
Computers in Biology and Medicine, 196: 110626. September 2025.\n
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@article{andonie_impedance-based_2025,\n\ttitle = {Impedance-based tissue response modeling for the prediction of hearing preservation after cochlear implantation},\n\tvolume = {196},\n\tissn = {00104825},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0010482525009771},\n\tdoi = {10.1016/j.compbiomed.2025.110626},\n\tlanguage = {en},\n\turldate = {2025-07-04},\n\tjournal = {Computers in Biology and Medicine},\n\tauthor = {Andonie, R. and Caversaccio, M. and Weder, S. and Wimmer, W.},\n\tmonth = sep,\n\tyear = {2025},\n\tpages = {110626},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Validation of a screw implantation safety index for bone conduction implants.\n \n \n \n \n\n\n \n Talon, E.; Bracher, S.; Aebischer, P.; Caversaccio, M.; Zysset, P.; and Wimmer, W.\n\n\n \n\n\n\n
Journal of Biomechanics, 189: 112827. August 2025.\n
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@article{talon_validation_2025,\n\ttitle = {Validation of a screw implantation safety index for bone conduction implants},\n\tvolume = {189},\n\tissn = {00219290},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0021929025003392},\n\tdoi = {10.1016/j.jbiomech.2025.112827},\n\tlanguage = {en},\n\turldate = {2025-07-02},\n\tjournal = {Journal of Biomechanics},\n\tauthor = {Talon, Emile and Bracher, Stefan and Aebischer, Philipp and Caversaccio, Marco and Zysset, Philippe and Wimmer, Wilhelm},\n\tmonth = aug,\n\tyear = {2025},\n\tpages = {112827},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Impedance-based detection of cochlear implant array migration: case report in a child with Aymé-Gripp syndrome.\n \n \n \n \n\n\n \n Schraivogel, S.; Regele, S.; Weiss, N. M.; Wirth, M.; Wollenberg, B.; Caversaccio, M.; and Wimmer, W.\n\n\n \n\n\n\n
European Archives of Oto-Rhino-Laryngology. April 2025.\n
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@article{schraivogel_impedance-based_2025,\n\ttitle = {Impedance-based detection of cochlear implant array migration: case report in a child with {Aymé}-{Gripp} syndrome},\n\tissn = {0937-4477, 1434-4726},\n\tshorttitle = {Impedance-based detection of cochlear implant array migration},\n\turl = {https://link.springer.com/10.1007/s00405-025-09397-7},\n\tdoi = {10.1007/s00405-025-09397-7},\n\tabstract = {Abstract\n \n Purpose\n Detection of complications during rehabilitation and postoperative follow-up after cochlear implantation is essential, especially in children and cognitively impaired patients. Electrode array migration can affect outcomes and must be detected early. Traditional radiographic methods, although effective, are costly and expose patients to radiation. This case report discusses the use of a previously published impedance-based model for cochlear implant array localization in a child with Aymé-Gripp syndrome.\n \n \n Methods\n Impedance telemetry data and X-ray images were collected at the time of initial surgery and before and after the required revision surgery. The impedance-based model was used to estimate the insertion depth of the most basal cochlear implant electrode within the cochlea. The resulting estimates were compared with the electrode positions from radiographs to assess the accuracy and applicability of the model.\n \n \n Results\n 20 months after implantation, the patient suddenly stopped tolerating the CI audio processor. Retrospectively, the impedance-based model revealed substantial electrode migration, which was confirmed by postoperative radiography.\n \n \n Conclusion\n The proposed model, which uses routine impedance telemetry data without radiation exposure, offers a cost-effective alternative to radiography. Early detection and intervention, particularly in complex cases, improves outcomes and reduces costs, highlighting the importance of objective monitoring.},\n\tlanguage = {en},\n\turldate = {2025-04-30},\n\tjournal = {European Archives of Oto-Rhino-Laryngology},\n\tauthor = {Schraivogel, Stephan and Regele, Sabrina and Weiss, Nora M. and Wirth, Markus and Wollenberg, Barbara and Caversaccio, Marco and Wimmer, Wilhelm},\n\tmonth = apr,\n\tyear = {2025},\n}\n\n\n\n
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\n Abstract Purpose Detection of complications during rehabilitation and postoperative follow-up after cochlear implantation is essential, especially in children and cognitively impaired patients. Electrode array migration can affect outcomes and must be detected early. Traditional radiographic methods, although effective, are costly and expose patients to radiation. This case report discusses the use of a previously published impedance-based model for cochlear implant array localization in a child with Aymé-Gripp syndrome. Methods Impedance telemetry data and X-ray images were collected at the time of initial surgery and before and after the required revision surgery. The impedance-based model was used to estimate the insertion depth of the most basal cochlear implant electrode within the cochlea. The resulting estimates were compared with the electrode positions from radiographs to assess the accuracy and applicability of the model. Results 20 months after implantation, the patient suddenly stopped tolerating the CI audio processor. Retrospectively, the impedance-based model revealed substantial electrode migration, which was confirmed by postoperative radiography. Conclusion The proposed model, which uses routine impedance telemetry data without radiation exposure, offers a cost-effective alternative to radiography. Early detection and intervention, particularly in complex cases, improves outcomes and reduces costs, highlighting the importance of objective monitoring.\n
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\n\n \n \n \n \n \n \n Comparison of Thiel-fixed and fresh-frozen temporal bones with dynamic synchrotron-based X-ray imaging.\n \n \n \n \n\n\n \n Schmeltz, M.; Ivanovic, A.; Schlepütz, C. M.; Wimmer, W.; Bonnin, A.; and Anschuetz, L.\n\n\n \n\n\n\n
Clinical Biomechanics,106522. April 2025.\n
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@article{schmeltz_comparison_2025,\n\ttitle = {Comparison of {Thiel}-fixed and fresh-frozen temporal bones with dynamic synchrotron-based {X}-ray imaging},\n\tissn = {02680033},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S0268003325000956},\n\tdoi = {10.1016/j.clinbiomech.2025.106522},\n\tlanguage = {en},\n\turldate = {2025-04-09},\n\tjournal = {Clinical Biomechanics},\n\tauthor = {Schmeltz, Margaux and Ivanovic, Aleksandra and Schlepütz, Christian M. and Wimmer, Wilhelm and Bonnin, Anne and Anschuetz, Lukas},\n\tmonth = apr,\n\tyear = {2025},\n\tpages = {106522},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Predictive Models for Radiation-Free Localization of Cochlear Implants' Most Basal Electrode Using Impedance Telemetry.\n \n \n \n \n\n\n \n Schraivogel, S.; Weder, S.; Mantokoudis, G.; Caversaccio, M.; and Wimmer, W.\n\n\n \n\n\n\n
IEEE Transactions on Biomedical Engineering, 72(4): 1453–1464. April 2025.\n
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@article{schraivogel_predictive_2025,\n\ttitle = {Predictive {Models} for {Radiation}-{Free} {Localization} of {Cochlear} {Implants}' {Most} {Basal} {Electrode} {Using} {Impedance} {Telemetry}},\n\tvolume = {72},\n\tcopyright = {https://creativecommons.org/licenses/by-nc-nd/4.0/},\n\tissn = {0018-9294, 1558-2531},\n\turl = {https://ieeexplore.ieee.org/document/10771996/},\n\tdoi = {10.1109/TBME.2024.3509527},\n\tnumber = {4},\n\turldate = {2025-03-24},\n\tjournal = {IEEE Transactions on Biomedical Engineering},\n\tauthor = {Schraivogel, Stephan and Weder, Stefan and Mantokoudis, Georgios and Caversaccio, Marco and Wimmer, Wilhelm},\n\tmonth = apr,\n\tyear = {2025},\n\tpages = {1453--1464},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Electrocochleography Latency: Correlation With Electrode Position During Cochlear Implantation.\n \n \n \n \n\n\n \n Andonie, R. R.; Wimmer, W.; Wildhaber, R. A.; Mantokoudis, G.; Caversaccio, M.; and Weder, S.\n\n\n \n\n\n\n
Ear & Hearing. February 2025.\n
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@article{andonie_electrocochleography_2025,\n\ttitle = {Electrocochleography {Latency}: {Correlation} {With} {Electrode} {Position} {During} {Cochlear} {Implantation}},\n\tissn = {1538-4667},\n\tshorttitle = {Electrocochleography {Latency}},\n\turl = {https://journals.lww.com/10.1097/AUD.0000000000001652},\n\tdoi = {10.1097/AUD.0000000000001652},\n\tabstract = {Objectives: \n Cochlear implant (CI) candidates increasingly exhibit some degree of residual hearing, which should be preserved despite the implantation. Today, cochlear health is monitored during CI surgery by tracking the cochlear microphonic (CM) amplitude from intracochlear electrocochleography (ECochG) measurements. However, recent studies indicate that the insertion depth of the measuring electrode must be considered to accurately interpret these signals. The acoustic path from the cochlear base to the apex induces excitation delays in deeper regions, which should be reflected in the CM measurements. In this study, we analyzed the potential of cochlear microphonic latency (CML) as an objective method for continuously tracking CI electrode position during cochlear implantation. In addition, we examined whether CML can be associated with residual hearing. \n \n \n Design: \n We recorded intraoperative pure-tone ECochG at maximum stimulation levels from 30 CI patients to derive CML. During CI electrode insertion, ECochG was continuously recorded at the 2 stimulation frequencies of 0.5 and 0.75 kHz. After complete insertion, ECochG was measured on all evenly numbered electrodes at frequencies of 0.25, 0.5, 0.75, and 1 kHz. The electrode locations (i.e., linear insertion depth) were identified by postoperative computed tomography (CT) scans. The location of the measuring electrode during the insertion period was then calculated backward, assuming a constant insertion speed. Finally, we used a linear regression model to relate CML to linear insertion depth. In addition, we evaluated the relationship between CML and preoperative residual hearing. \n \n \n Results: \n \n CML is significantly correlated to the linear insertion depth ( \n p \n {\\textless} 0.001) during and after electrode insertion (with restrictions on 0.25 kHz stimulus, presumably since the characteristic 0.25 kHz region is not within reach of the used CI electrode arrays). Despite high inter-individual variability, our results align with documented delays in the basilar membrane observed in other studies. However, we could not identify a significant association between CML and residual hearing. \n \n \n \n Conclusions: \n Our study demonstrates that objectively extracted CML encodes the intracochlear electrode location in CI patients but is not directly linked to residual hearing. Consequently, CML has the potential to enhance intraoperative ECochG analysis by providing real-time tracking of electrode position. To better understand the inter-individual variations in CML, future studies with larger patient cohorts are needed.},\n\tlanguage = {en},\n\turldate = {2025-02-27},\n\tjournal = {Ear \\& Hearing},\n\tauthor = {Andonie, Raphael R. and Wimmer, Wilhelm and Wildhaber, Reto A. and Mantokoudis, Georgios and Caversaccio, Marco and Weder, Stefan},\n\tmonth = feb,\n\tyear = {2025},\n}\n\n\n\n
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\n Objectives: Cochlear implant (CI) candidates increasingly exhibit some degree of residual hearing, which should be preserved despite the implantation. Today, cochlear health is monitored during CI surgery by tracking the cochlear microphonic (CM) amplitude from intracochlear electrocochleography (ECochG) measurements. However, recent studies indicate that the insertion depth of the measuring electrode must be considered to accurately interpret these signals. The acoustic path from the cochlear base to the apex induces excitation delays in deeper regions, which should be reflected in the CM measurements. In this study, we analyzed the potential of cochlear microphonic latency (CML) as an objective method for continuously tracking CI electrode position during cochlear implantation. In addition, we examined whether CML can be associated with residual hearing. Design: We recorded intraoperative pure-tone ECochG at maximum stimulation levels from 30 CI patients to derive CML. During CI electrode insertion, ECochG was continuously recorded at the 2 stimulation frequencies of 0.5 and 0.75 kHz. After complete insertion, ECochG was measured on all evenly numbered electrodes at frequencies of 0.25, 0.5, 0.75, and 1 kHz. The electrode locations (i.e., linear insertion depth) were identified by postoperative computed tomography (CT) scans. The location of the measuring electrode during the insertion period was then calculated backward, assuming a constant insertion speed. Finally, we used a linear regression model to relate CML to linear insertion depth. In addition, we evaluated the relationship between CML and preoperative residual hearing. Results: CML is significantly correlated to the linear insertion depth ( p \\textless 0.001) during and after electrode insertion (with restrictions on 0.25 kHz stimulus, presumably since the characteristic 0.25 kHz region is not within reach of the used CI electrode arrays). Despite high inter-individual variability, our results align with documented delays in the basilar membrane observed in other studies. However, we could not identify a significant association between CML and residual hearing. Conclusions: Our study demonstrates that objectively extracted CML encodes the intracochlear electrode location in CI patients but is not directly linked to residual hearing. Consequently, CML has the potential to enhance intraoperative ECochG analysis by providing real-time tracking of electrode position. To better understand the inter-individual variations in CML, future studies with larger patient cohorts are needed.\n
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\n\n \n \n \n \n \n \n Effects of early test termination in a German matrix speech test in noise in cochlear implant recipients.\n \n \n \n \n\n\n \n Schmid, C.; Kompis, M.; and Wimmer, W.\n\n\n \n\n\n\n
Acta Oto-Laryngologica,1–6. February 2025.\n
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@article{schmid_effects_2025,\n\ttitle = {Effects of early test termination in a {German} matrix speech test in noise in cochlear implant recipients},\n\tissn = {0001-6489, 1651-2251},\n\turl = {https://www.tandfonline.com/doi/full/10.1080/00016489.2025.2454479},\n\tdoi = {10.1080/00016489.2025.2454479},\n\tlanguage = {en},\n\turldate = {2025-02-21},\n\tjournal = {Acta Oto-Laryngologica},\n\tauthor = {Schmid, Christoph and Kompis, Martin and Wimmer, Wilhelm},\n\tmonth = feb,\n\tyear = {2025},\n\tpages = {1--6},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Second order kinematic surface fitting in anatomical structures.\n \n \n \n \n\n\n \n Wimmer, W.; and Delingette, H.\n\n\n \n\n\n\n
Medical Image Analysis,103488. February 2025.\n
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@article{wimmer_second_2025,\n\ttitle = {Second order kinematic surface fitting in anatomical structures},\n\tissn = {13618415},\n\turl = {https://linkinghub.elsevier.com/retrieve/pii/S1361841525000362},\n\tdoi = {10.1016/j.media.2025.103488},\n\tlanguage = {en},\n\turldate = {2025-02-08},\n\tjournal = {Medical Image Analysis},\n\tauthor = {Wimmer, Wilhelm and Delingette, Hervé},\n\tmonth = feb,\n\tyear = {2025},\n\tpages = {103488},\n}\n\n\n\n
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\n\n \n \n \n \n \n \n Dynamic X-ray Microtomography vs. Laser-Doppler Vibrometry: A Comparative Study.\n \n \n \n \n\n\n \n Ivanovic, A.; Cheng, J. T.; Schmeltz, M.; Wimmer, W.; Schlepuetz, C. M.; Remenschneider, A. K.; Bonnin, A.; and Anschuetz, L.\n\n\n \n\n\n\n
Journal of the Association for Research in Otolaryngology. January 2025.\n
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@article{ivanovic_dynamic_2025,\n\ttitle = {Dynamic {X}-ray {Microtomography} vs. {Laser}-{Doppler} {Vibrometry}: {A} {Comparative} {Study}},\n\tissn = {1438-7573},\n\tshorttitle = {Dynamic {X}-ray {Microtomography} vs. {Laser}-{Doppler} {Vibrometry}},\n\turl = {https://link.springer.com/10.1007/s10162-024-00971-0},\n\tdoi = {10.1007/s10162-024-00971-0},\n\tabstract = {Abstract\n \n Purpose\n There are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV).\n \n \n Methods\n We examined three fresh-frozen temporal bones (TB), two donated by white males and one by a Black female, using dynamic synchrotron-based X-ray microtomography for 256 and 512 Hz, stimulated at 110 dB and 120 dB sound pressure level (SPL). In addition, we performed measurements on these TBs using 1D LDV, a well-established method.\n \n \n Results\n The normalized displacement values (µm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5–10 dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques.\n \n \n Conclusion\n In conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear’s biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.},\n\tlanguage = {en},\n\turldate = {2025-01-21},\n\tjournal = {Journal of the Association for Research in Otolaryngology},\n\tauthor = {Ivanovic, Aleksandra and Cheng, Jeffrey Tao and Schmeltz, Margaux and Wimmer, Wilhelm and Schlepuetz, Christian M. and Remenschneider, Aaron K. and Bonnin, Anne and Anschuetz, Lukas},\n\tmonth = jan,\n\tyear = {2025},\n}\n\n\n\n
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\n Abstract Purpose There are challenges in understanding the biomechanics of the human middle ear, and established methods for studying this system show significant limitations. In this study, we evaluate a novel dynamic imaging technique based on synchrotron X-ray microtomography designed to assess the biomechanical properties of the human middle ear by comparing it to laser-Doppler vibrometry (LDV). Methods We examined three fresh-frozen temporal bones (TB), two donated by white males and one by a Black female, using dynamic synchrotron-based X-ray microtomography for 256 and 512 Hz, stimulated at 110 dB and 120 dB sound pressure level (SPL). In addition, we performed measurements on these TBs using 1D LDV, a well-established method. Results The normalized displacement values (µm/Pa) at the umbo and the posterior crus of the stapes are consistent or within 5–10 dB differences between all LDV and dynamic microtomography measurements and previously reported literature references. In general, the overall behavior is similar between the two measurement techniques. Conclusion In conclusion, our results demonstrate the suitability of dynamic synchrotron-based X-ray microtomography in studying the middle ear’s biomechanics. However, this study shows that better standardization regarding acoustic stimulation and measurement points is needed to better compare the two measurement techniques.\n
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\n\n \n \n \n \n \n \n Electrocochleography in Cochlear Implant Recipients: Correlating Maximum Response With Residual Hearing.\n \n \n \n \n\n\n \n Andonie, R. R.; Wimmer, W.; Schraivogel, S.; Mantokoudis, G.; Caversaccio, M.; and Weder, S.\n\n\n \n\n\n\n
Ear & Hearing, 46(1): 16–23. January 2025.\n
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@article{andonie_electrocochleography_2025,\n\ttitle = {Electrocochleography in {Cochlear} {Implant} {Recipients}: {Correlating} {Maximum} {Response} {With} {Residual} {Hearing}},\n\tvolume = {46},\n\tissn = {1538-4667},\n\tshorttitle = {Electrocochleography in {Cochlear} {Implant} {Recipients}},\n\turl = {https://journals.lww.com/10.1097/AUD.0000000000001546},\n\tdoi = {10.1097/AUD.0000000000001546},\n\tabstract = {Objectives:\n Electrocochleography (ECochG) is increasingly recognized as a biomarker for assessing inner ear function in cochlear implant patients. This study aimed to objectively determine intraoperative cochlear microphonic (CM) amplitude patterns and correlate them with residual hearing in cochlear implant recipients, addressing the limitations in current ECochG analysis that often depends on subjective visual assessment and overlook the intracochlear measurement location.\n \n \n Design:\n In this prospective study, we investigated intraoperative pure-tone ECochG following complete electrode insertion in 31 patients. We used our previously published objective analysis method to determine the maximum CM amplitude and the associated electrode position for each electrode array. Using computed tomography, we identified electrode placement and determined the corresponding tonotopic frequency using Greenwood’s function. Based on this, we calculated the tonotopic shift, that is, the difference between the stimulation frequency and the estimated frequency of the electrode with the maximum CM amplitude. We evaluated the association between CM amplitude, tonotopic shift, and preoperative hearing thresholds using linear regression analysis.\n \n \n Results:\n CM amplitudes showed high variance, with values ranging from −1.479 \n \n \n \n to 4.495 dBµV. We found a statistically significant negative correlation (\n \n \n \n ) between maximum CM amplitudes and preoperative hearing thresholds. In addition, a significant association (\n \n \n \n ) between the tonotopic shift and preoperative hearing thresholds was observed. Tonotopic shifts of the maximum CM amplitudes occurred predominantly toward the basal direction.\n \n \n Conclusions:\n The combination of objective signal analysis and the consideration of intracochlear measurement locations enhances the understanding of cochlear health and overcomes the obstacles of current ECochG analysis. We could show the link between intraoperative CM amplitudes, their spatial distributions, and preoperative hearing thresholds. Consequently, our findings enable automated analysis and bear the potential to enhance specificity of ECochG, reinforcing its role as an objective biomarker for cochlear health.},\n\tlanguage = {en},\n\tnumber = {1},\n\turldate = {2025-01-04},\n\tjournal = {Ear \\& Hearing},\n\tauthor = {Andonie, Raphael R. and Wimmer, Wilhelm and Schraivogel, Stephan and Mantokoudis, Georgios and Caversaccio, Marco and Weder, Stefan},\n\tmonth = jan,\n\tyear = {2025},\n\tpages = {16--23},\n}\n\n\n\n
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\n Objectives: Electrocochleography (ECochG) is increasingly recognized as a biomarker for assessing inner ear function in cochlear implant patients. This study aimed to objectively determine intraoperative cochlear microphonic (CM) amplitude patterns and correlate them with residual hearing in cochlear implant recipients, addressing the limitations in current ECochG analysis that often depends on subjective visual assessment and overlook the intracochlear measurement location. Design: In this prospective study, we investigated intraoperative pure-tone ECochG following complete electrode insertion in 31 patients. We used our previously published objective analysis method to determine the maximum CM amplitude and the associated electrode position for each electrode array. Using computed tomography, we identified electrode placement and determined the corresponding tonotopic frequency using Greenwood’s function. Based on this, we calculated the tonotopic shift, that is, the difference between the stimulation frequency and the estimated frequency of the electrode with the maximum CM amplitude. We evaluated the association between CM amplitude, tonotopic shift, and preoperative hearing thresholds using linear regression analysis. Results: CM amplitudes showed high variance, with values ranging from −1.479 to 4.495 dBµV. We found a statistically significant negative correlation ( ) between maximum CM amplitudes and preoperative hearing thresholds. In addition, a significant association ( ) between the tonotopic shift and preoperative hearing thresholds was observed. Tonotopic shifts of the maximum CM amplitudes occurred predominantly toward the basal direction. Conclusions: The combination of objective signal analysis and the consideration of intracochlear measurement locations enhances the understanding of cochlear health and overcomes the obstacles of current ECochG analysis. We could show the link between intraoperative CM amplitudes, their spatial distributions, and preoperative hearing thresholds. Consequently, our findings enable automated analysis and bear the potential to enhance specificity of ECochG, reinforcing its role as an objective biomarker for cochlear health.\n
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