var bibbase_data = {"data":"<img src=\"//bibbase.org/img/ajax-loader.gif\" id=\"spinner\"\n  style=\"display: none;\" alt=\"Loading..\" />\n\n<div id=\"bibbase\">\n\n  <script type=\"text/javascript\">\n    var bibbase = {\n      params: {\"bib\":\"https://bio.pnpi.nrcki.ru/wp-content/uploads/2019/12/cdki_2019_10.txt\",\"jsonp\":\"1\",\"host\":\"bibbase.org\",\"ssl\":false},\n      data: [{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Litvinenko\"],\"firstnames\":[\"I.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yakovleva\"],\"firstnames\":[\"V.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ryabtsev\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Churilov\"],\"firstnames\":[\"L.P.\"],\"suffixes\":[]}],\"title\":\"Autoimmunity in acute ischemic stroke and the role of blood-brain barrier: the dark side or the light one?\",\"journal\":\"Frontiers of Medicine\",\"year\":\"2019\",\"volume\":\"13\",\"number\":\"4\",\"pages\":\"420-426\",\"doi\":\"10.1007/s11684-019-0688-6\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064341869&doi=10.1007%2fs11684-019-0688-6&partnerID=40&md5=4e09f1f2e1fb7a496df0344ab1b0ee31\",\"affiliation\":\"Department of Molecular and Radiation Biophysics, B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Leningrad Region, 188300, Russian Federation; Department of Nervous Diseases, S.M. Kirov Military Medical Academy, Saint Petersburg, 194044, Russian Federation; Department of Experimental Pharmacology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Saint Petersburg, 194223, Russian Federation; Department of Pathological Physiology with the Course of Immunopathology, Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation; Department of Pathology, Laboratory of the Mosaic of Autoimmunity, Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation\",\"abstract\":\"This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia-reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising. © 2019, Higher Education Press and Springer-Verlag GmbH, Germany, part of Springer Nature.\",\"author_keywords\":\"autoimmunity; blood-brain barrier; cell death; inflammation; innate immunity; stroke\",\"funding_details\":\"Government Council on Grants, Russian FederationW03.31.0009, 15.34.3.2017\",\"key\":\"Tsygan2019420\",\"id\":\"Tsygan2019420\",\"bibbaseid\":\"anonymous-autoimmunityinacuteischemicstrokeandtheroleofbloodbrainbarrierthedarksideorthelightone-2019\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064341869&doi=10.1007%2fs11684-019-0688-6&partnerID=40&md5=4e09f1f2e1fb7a496df0344ab1b0ee31\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Litvinenko\"],\"firstnames\":[\"I.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Odinak\"],\"firstnames\":[\"M.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Andreev\"],\"firstnames\":[\"R.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Peleshok\"],\"firstnames\":[\"A.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kurasov\"],\"firstnames\":[\"E.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yakovleva\"],\"firstnames\":[\"V.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ryabtsev\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]}],\"title\":\"Characteristics of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve\",\"journal\":\"Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova\",\"year\":\"2019\",\"volume\":\"119\",\"number\":\"2\",\"pages\":\"18-22\",\"doi\":\"10.17116/jnevro201911902118\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&doi=10.17116%2fjnevro201911902118&partnerID=40&md5=361a4ae7b1be819ac3bf90149cfd0de6\",\"affiliation\":\"Kirov Military Medical Academy, St.-Petersburg, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Leningrad region, Russian Federation; Dzhanelidze St.-Petersburg Research Institute of Emergency Medicine, St.-Petersburg, Russian Federation\",\"abstract\":\"Objective. To study the prevalence and structure of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve in patients who underwent surgery for the acquired heart valve disease. Material and methods. The study included 115 patients (70 men and 45 women; 64 [56; 72] years old), who underwent elective replacement or repair surgery for the acquired heart valve disease. Results and conclusion. The postoperative cerebral dysfunction was diagnosed in 40.9% patients, including replacement in the aortic position (45.5%), in the mitral position (55%), in several positions (20%). Replacement surgery was accompanied by three clinical types of postoperative cerebral dysfunction and repair surgery — by deferred cognitive impairment only. Postoperative cerebral dysfunction after the replacement in the mitral position was more common (odds ratio 4.47, 95% confidence interval 1.21—18.35, p=0.041), including its acute clinical types — perioperative stroke and symptomatic delirium of the early postoperative period (p=0.029), compared to that after the repair heart valve surgery. After the replacement in the aortic position, acute clinical types of postoperative cerebral dysfunction were more common (p=0.036). After the replacement with biological prosthesis, symptomatic delirium of the early postoperative period was more common (p=0.047). The occurrence of the deferred cognitive impairment didn’t depend on the type and position of the implanted prosthetic heart valve. © 2019, Media Sphera Publishing Group. All right reserved.\",\"author_keywords\":\"Acquired heart valve disease; Deferred cognitive impairment; Heart valve repair surgery; Heart valve replacement surgery; Perioperative stroke; Postoperative cerebral dysfunction; Symptomatic delirium of the early postoperative period\",\"correspondence_address1\":\"Tsygan, N.V.; Kirov Military Medical AcademyRussian Federation; email: 77tn77@gmail.com\",\"publisher\":\"Media Sphera Publishing Group\",\"issn\":\"19977298\",\"pubmed_id\":\"30874521\",\"language\":\"Russian\",\"abbrev_source_title\":\"Zh. Nevrologii Psihiatrii im. S.S. Korsakova\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Litvinenko201918,\\r\\nauthor={Litvinenko, I.V. and Odinak, M.M. and Tsygan, N.V. and Andreev, R.V. and Peleshok, A.S. and Kurasov, E.S. and Yakovleva, V.A. and Ryabtsev, A.V.},\\r\\ntitle={Characteristics of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve},\\r\\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\\r\\nyear={2019},\\r\\nvolume={119},\\r\\nnumber={2},\\r\\npages={18-22},\\r\\ndoi={10.17116/jnevro201911902118},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&doi=10.17116%2fjnevro201911902118&partnerID=40&md5=361a4ae7b1be819ac3bf90149cfd0de6},\\r\\naffiliation={Kirov Military Medical Academy, St.-Petersburg, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Leningrad region, Russian Federation; Dzhanelidze St.-Petersburg Research Institute of Emergency Medicine, St.-Petersburg, Russian Federation},\\r\\nabstract={Objective. To study the prevalence and structure of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve in patients who underwent surgery for the acquired heart valve disease. Material and methods. The study included 115 patients (70 men and 45 women; 64 [56; 72] years old), who underwent elective replacement or repair surgery for the acquired heart valve disease. Results and conclusion. The postoperative cerebral dysfunction was diagnosed in 40.9% patients, including replacement in the aortic position (45.5%), in the mitral position (55%), in several positions (20%). Replacement surgery was accompanied by three clinical types of postoperative cerebral dysfunction and repair surgery — by deferred cognitive impairment only. Postoperative cerebral dysfunction after the replacement in the mitral position was more common (odds ratio 4.47, 95% confidence interval 1.21—18.35, p=0.041), including its acute clinical types — perioperative stroke and symptomatic delirium of the early postoperative period (p=0.029), compared to that after the repair heart valve surgery. After the replacement in the aortic position, acute clinical types of postoperative cerebral dysfunction were more common (p=0.036). After the replacement with biological prosthesis, symptomatic delirium of the early postoperative period was more common (p=0.047). The occurrence of the deferred cognitive impairment didn’t depend on the type and position of the implanted prosthetic heart valve. © 2019, Media Sphera Publishing Group. All right reserved.},\\r\\nauthor_keywords={Acquired heart valve disease;  Deferred cognitive impairment;  Heart valve repair surgery;  Heart valve replacement surgery;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},\\r\\ncorrespondence_address1={Tsygan, N.V.; Kirov Military Medical AcademyRussian Federation; email: 77tn77@gmail.com},\\r\\npublisher={Media Sphera Publishing Group},\\r\\nissn={19977298},\\r\\npubmed_id={30874521},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Litvinenko, I.\",\"Odinak, M.\",\"Tsygan, N.\",\"Andreev, R.\",\"Peleshok, A.\",\"Kurasov, E.\",\"Yakovleva, V.\",\"Ryabtsev, A.\"],\"key\":\"Litvinenko201918\",\"id\":\"Litvinenko201918\",\"bibbaseid\":\"litvinenko-odinak-tsygan-andreev-peleshok-kurasov-yakovleva-ryabtsev-characteristicsofpostoperativecerebraldysfunctiondependingonthetypeandpositionoftheimplantedprostheticheartvalve-2019\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&doi=10.17116%2fjnevro201911902118&partnerID=40&md5=361a4ae7b1be819ac3bf90149cfd0de6\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"conference\",\"type\":\"conference\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Stupin\"],\"firstnames\":[\"D.D.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Koniakhin\"],\"firstnames\":[\"S.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]}],\"title\":\"An inexpensive MP3-Player based 45-kHz band noise generator for engineering and scientific applications\",\"journal\":\"Journal of Physics: Conference Series\",\"year\":\"2018\",\"volume\":\"1038\",\"number\":\"1\",\"doi\":\"10.1088/1742-6596/1038/1/012038\",\"art_number\":\"012038\",\"note\":\"cited By 0; Conference of International Conference PhysicA.SPb 2017 ; Conference Date: 24 October 2017 Through 26 October 2017; Conference Code:137476\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049534345&doi=10.1088%2f1742-6596%2f1038%2f1%2f012038&partnerID=40&md5=98e5b7679d5b1cd056c9c5aadf028dc6\",\"affiliation\":\"St. Petersburg Academic University, Khlopina 8/3, St.-Petersburg, 194021, Russian Federation; Petersburg Nuclear Physics Institute NRC Kurchatov Institute, Gatchina, St.-Petersburg, 188300, Russian Federation\",\"abstract\":\"In this study we propose a home-made setup based on MP3 Player for producing high quality noise-like shape voltage with 45-kHz frequency band. The proposed generator's output signal is investigated both theoretically and experimentally. © Published under licence by IOP Publishing Ltd.\",\"funding_details\":\"Ministry of Education and Science of the Russian Federation16.9790.2017/BCh\",\"key\":\"Stupin2018\",\"id\":\"Stupin2018\",\"bibbaseid\":\"anonymous-aninexpensivemp3playerbased45khzbandnoisegeneratorforengineeringandscientificapplications-2018\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049534345&doi=10.1088%2f1742-6596%2f1038%2f1%2f012038&partnerID=40&md5=98e5b7679d5b1cd056c9c5aadf028dc6\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"conference\",\"type\":\"conference\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Klimenko\"],\"firstnames\":[\"V.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kaydanov\"],\"firstnames\":[\"N.E.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Emelyanov\"],\"firstnames\":[\"A.K.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shmakov\"],\"firstnames\":[\"S.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Knyazev\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bogdanov\"],\"firstnames\":[\"A.A.\"],\"suffixes\":[]}],\"title\":\"Inhibition of Taq polymerase activity by singlet oxygen generation at photodynamic therapy\",\"journal\":\"Journal of Physics: Conference Series\",\"year\":\"2018\",\"volume\":\"1038\",\"number\":\"1\",\"doi\":\"10.1088/1742-6596/1038/1/012031\",\"art_number\":\"012031\",\"note\":\"cited By 0; Conference of International Conference PhysicA.SPb 2017 ; Conference Date: 24 October 2017 Through 26 October 2017; Conference Code:137476\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049525797&doi=10.1088%2f1742-6596%2f1038%2f1%2f012031&partnerID=40&md5=86c327e5db5df3e00decc0ca9c1bc4ff\",\"affiliation\":\"St Petersburg Academic University, St-Petersburg, Russian Federation; St. Petersburg Clinical Scientific and Practical Center for Special Types of Medical Care, St.-Petersburg, Russian Federation; Petersburg Nuclear Physics Institute NRC Kurchatov Institute, Gatchina, Russian Federation; Institute of Cytology, St Petersburg, Russian Federation; ITMO University, St.-Petersburg, Russian Federation\",\"abstract\":\"The goal of this study was to assess the ability of singlet oxygen generated at PDT to inhibit the activity of the model enzyme - Taq polymerase. Experimentally were determined the laser irradiation dose and the singlet oxygen concentration (over 300 μM) that results to complete inhibition of Taq polymerase activity. The results show that enzymatic proteins have an order of magnitude higher susceptibility than DNA molecules to damage by singlet oxygen. © Published under licence by IOP Publishing Ltd.\",\"funding_details\":\"16-04-01858 a.\",\"key\":\"Klimenko2018\",\"id\":\"Klimenko2018\",\"bibbaseid\":\"anonymous-inhibitionoftaqpolymeraseactivitybysingletoxygengenerationatphotodynamictherapy-2018\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049525797&doi=10.1088%2f1742-6596%2f1038%2f1%2f012031&partnerID=40&md5=86c327e5db5df3e00decc0ca9c1bc4ff\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Shtam\"],\"firstnames\":[\"T.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Samsonov\"],\"firstnames\":[\"R.B.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Volnitskiy\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kamyshinsky\"],\"firstnames\":[\"R.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kniazeva\"],\"firstnames\":[\"M.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Korobkina\"],\"firstnames\":[\"E.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Orehov\"],\"firstnames\":[\"A.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Konevega\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Malek\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]}],\"title\":\"Isolation of Extracellular Microvesicles from Cell Culture Medium: Comparative Evaluation of Methods\",\"journal\":\"Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry\",\"year\":\"2018\",\"volume\":\"12\",\"number\":\"2\",\"pages\":\"167-175\",\"doi\":\"10.1134/S1990750818020117\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047785286&doi=10.1134%2fS1990750818020117&partnerID=40&md5=8e974b0f5e74292fce4ff3287267324b\",\"affiliation\":\"Petersburg Nuclear Physics Institute of National Research Centre Kurchatov Institute, Saint-Petersburg, Gatchina, 188300, Russian Federation; Oncosystem Ltd., Skolkovo, 143026, Russian Federation; Petrov National Medical Research Center of Oncology, St. Petersburg, 197758, Russian Federation; National Research Center Kurchatov Institute, Moscow, 123182, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, 195251, Russian Federation\",\"abstract\":\"Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by “horizontal” exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional EV features are usually studied in vitro. Several methods of EV isolation from cell culture medium are currently used; however, selection of a particular method may have a significant impact on obtained results. The choice of the optimal method is usually determined by the amount of starting biomaterial and the aims of the research. We have performed a comparative analysis of four different methods of EV isolation from cell culture medium: differential ultracentrifugation, ultracentrifugation with 30% sucrose/D 2 O “cushion,” precipitation with plant proteins and latex-based immunoaffinity capturing. EV isolated from several human glial cell lines by different approaches were compared in terms of the following parameters: size, concentration, EV morphology, contamination by non-vesicular particles, content of exosomal tetraspanins on the EV surface, content of total proteins, total RNA, and several glioma-associated miRNAs. The applied methods included nanoparticle tracking analysis (NTA), dynamic light scattering (DLS), cryo-electron microscopy, flow cytometry and RT-qPCR. Based on the obtained results, we have developed practical recommendations that may help researchers to make the best choice of the EV isolation method. © 2018, Pleiades Publishing, Ltd.\",\"author_keywords\":\"exsosomes; extracellular vesicles; immunoprecipitation; lectines; methods of isolation; ultracentrifugation\",\"funding_details\":\"Russian Science Foundation17-75-20159, 17-14-01416\",\"key\":\"Shtam2018167\",\"id\":\"Shtam2018167\",\"bibbaseid\":\"anonymous-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047785286&doi=10.1134%2fS1990750818020117&partnerID=40&md5=8e974b0f5e74292fce4ff3287267324b\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Churilov\"],\"firstnames\":[\"L.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Utekhin\"],\"firstnames\":[\"V.I.\"],\"suffixes\":[]}],\"title\":\"Evolution of the immune system and regulatory effects of antibodies\",\"journal\":\"Tsitologiya\",\"year\":\"2018\",\"volume\":\"60\",\"number\":\"2\",\"pages\":\"71-80\",\"doi\":\"10.31116/tsitol.2018.02.01\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&doi=10.31116%2ftsitol.2018.02.01&partnerID=40&md5=4f72752ca24dd84fcf15a3c741525d12\",\"affiliation\":\"St. Petersburg State Pediatric Medical University, St. Petersburg, 194353, Russian Federation; St. Petersburg State University, St. Petersburg, 199106, Russian Federation; Petersburg Nuclear Physics Institute named by, B. P. Konstantinov of National Research Centre «Kurchatov Institute», Gatchina, 188300, Russian Federation\",\"abstract\":\"The immune system is usually regarded as a tool for defense against pathogens. The review however focuses at non-traditional aspects of immune system activity that are seldom discussed. Immunoglobulins are products of genes super-family which is a part of cell adhesion molecules genes associated with multicellularity and thus in addition to regulation of immune response antibodies may accomplish integrative regulatory effects outside immune system using the very same principles (complementarity, positive and negative feedback, etc.), that are characteristic of the nervous and endocrine systems. The review sums up general principles of the antibodies’ regulatory effects in physiologic and pathologic processes as well as mechanisms that help them penetrate intact cell membrane and travel further into the nucleus and the principles of their intracellular activity by means of repression (derepression) of key cellular structures. © 2018 Sankt Peterburg.All rights reserved.\",\"author_keywords\":\"Antinuclear antibodies; Derepression; Immunoglobuline regulation; Regulatory effects of antibodies; Repression\",\"correspondence_address1\":\"Vasiliev, A.G.; St. Petersburg State Pediatric Medical UniversityRussian Federation; email: avas7@mail.ru\",\"publisher\":\"Sankt Peterburg\",\"issn\":\"00413771\",\"coden\":\"TSITA\",\"language\":\"Russian\",\"abbrev_source_title\":\"Tsitologiya\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Vasiliev201871,\\r\\nauthor={Vasiliev, A.G. and Churilov, L.P. and Trashkov, A.P. and Utekhin, V.I.},\\r\\ntitle={Evolution of the immune system and regulatory effects of antibodies},\\r\\njournal={Tsitologiya},\\r\\nyear={2018},\\r\\nvolume={60},\\r\\nnumber={2},\\r\\npages={71-80},\\r\\ndoi={10.31116/tsitol.2018.02.01},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&doi=10.31116%2ftsitol.2018.02.01&partnerID=40&md5=4f72752ca24dd84fcf15a3c741525d12},\\r\\naffiliation={St. Petersburg State Pediatric Medical University, St. Petersburg, 194353, Russian Federation; St. Petersburg State University, St. Petersburg, 199106, Russian Federation; Petersburg Nuclear Physics Institute named by, B. P. Konstantinov of National Research Centre «Kurchatov Institute», Gatchina, 188300, Russian Federation},\\r\\nabstract={The immune system is usually regarded as a tool for defense against pathogens. The review however focuses at non-traditional aspects of immune system activity that are seldom discussed. Immunoglobulins are products of genes super-family which is a part of cell adhesion molecules genes associated with multicellularity and thus in addition to regulation of immune response antibodies may accomplish integrative regulatory effects outside immune system using the very same principles (complementarity, positive and negative feedback, etc.), that are characteristic of the nervous and endocrine systems. The review sums up general principles of the antibodies’ regulatory effects in physiologic and pathologic processes as well as mechanisms that help them penetrate intact cell membrane and travel further into the nucleus and the principles of their intracellular activity by means of repression (derepression) of key cellular structures. © 2018 Sankt Peterburg.All rights reserved.},\\r\\nauthor_keywords={Antinuclear antibodies;  Derepression;  Immunoglobuline regulation;  Regulatory effects of antibodies;  Repression},\\r\\ncorrespondence_address1={Vasiliev, A.G.; St. Petersburg State Pediatric Medical UniversityRussian Federation; email: avas7@mail.ru},\\r\\npublisher={Sankt Peterburg},\\r\\nissn={00413771},\\r\\ncoden={TSITA},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Tsitologiya},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Vasiliev, A.\",\"Churilov, L.\",\"Trashkov, A.\",\"Utekhin, V.\"],\"key\":\"Vasiliev201871\",\"id\":\"Vasiliev201871\",\"bibbaseid\":\"vasiliev-churilov-trashkov-utekhin-evolutionoftheimmunesystemandregulatoryeffectsofantibodies-2018\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&doi=10.31116%2ftsitol.2018.02.01&partnerID=40&md5=4f72752ca24dd84fcf15a3c741525d12\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Andreev\"],\"firstnames\":[\"R.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Peleshok\"],\"firstnames\":[\"A.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kolomentsev\"],\"firstnames\":[\"S.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yakovleva\"],\"firstnames\":[\"V.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ryabtsev\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gumennaya\"],\"firstnames\":[\"M.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Litvinenko\"],\"firstnames\":[\"I.V.\"],\"suffixes\":[]}],\"title\":\"Perioperative stroke in heart valve surgery: Pathogenesis, clinical findings, diagnosis, prevention, treatment\",\"journal\":\"Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova\",\"year\":\"2018\",\"volume\":\"118\",\"number\":\"4\",\"pages\":\"52-60\",\"doi\":\"10.17116/jnevro20181184152-60\",\"note\":\"cited By 1\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&doi=10.17116%2fjnevro20181184152-60&partnerID=40&md5=131b0d4388095a7f8bbc47747a3505af\",\"affiliation\":\"Kirov Military Medical Academy, St. Petersburg, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russian Federation; Dzhanelidze St. Petersburg Research Institute of Emergency Medicine, St. Petersburg, Russian Federation; Sechenov Institute of Evolutionary Biochemistry and Physiology of Russian Academy of Science, St. Petersburg, Russian Federation\",\"abstract\":\"Objective. To study risk factors, characteristics of clinical symptoms and diagnosis, and possibilities of prevention of perioperative stroke and other clinical types of cerebral dysfunction in main types of heart valve surgery. Material and methods. The study included 83 patients, aged 63 (54; 70) years, undergoing heart valve surgery with cardiopulmonary bypass. Results. Postoperative cerebral dysfunction was diagnosed in 37.3% of cases, including perioperative stroke in 3.6% of cases. In cases of aortic stenosis, the frequency of perioperative stroke was 9.5%. The cardioembolic subtype of perioperative ischemic stroke in cardiac valve surgery was most likely. The risk factors of the symptomatic delirium of the early postoperative period are: age over 75 years, preoperative frontal dysfunction, duration of artificial respiratory care more than 20 hours after the surgery. Conclusion. The results suggest the efficacy of preventive use of cytoflavin for reducing the frequency and severity of perioperative stroke and symptomatic delirium of the early postoperative period in heart valve surgery with cardiopulmonary bypass. © 2018, Media Sphera Publishing Group. All Rights Reserved.\",\"author_keywords\":\"Cardiopulmonary bypass; Cytoflavin; Delayed cognitive impairment; Heart valve surgery; Perioperative stroke; Postoperative cerebral dysfunction; Symptomatic delirium of the early postoperative period\",\"publisher\":\"Media Sphera Publishing Group\",\"issn\":\"19977298\",\"pubmed_id\":\"29863693\",\"language\":\"Russian\",\"abbrev_source_title\":\"Zh. Nevrologii Psihiatrii im. S.S. Korsakova\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Tsygan201852,\\r\\nauthor={Tsygan, N.V. and Andreev, R.V. and Peleshok, A.S. and Kolomentsev, S.V. and Yakovleva, V.A. and Ryabtsev, A.V. and Gumennaya, M.A. and Litvinenko, I.V.},\\r\\ntitle={Perioperative stroke in heart valve surgery: Pathogenesis, clinical findings, diagnosis, prevention, treatment},\\r\\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\\r\\nyear={2018},\\r\\nvolume={118},\\r\\nnumber={4},\\r\\npages={52-60},\\r\\ndoi={10.17116/jnevro20181184152-60},\\r\\nnote={cited By 1},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&doi=10.17116%2fjnevro20181184152-60&partnerID=40&md5=131b0d4388095a7f8bbc47747a3505af},\\r\\naffiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russian Federation; Dzhanelidze St. Petersburg Research Institute of Emergency Medicine, St. Petersburg, Russian Federation; Sechenov Institute of Evolutionary Biochemistry and Physiology of Russian Academy of Science, St. Petersburg, Russian Federation},\\r\\nabstract={Objective. To study risk factors, characteristics of clinical symptoms and diagnosis, and possibilities of prevention of perioperative stroke and other clinical types of cerebral dysfunction in main types of heart valve surgery. Material and methods. The study included 83 patients, aged 63 (54; 70) years, undergoing heart valve surgery with cardiopulmonary bypass. Results. Postoperative cerebral dysfunction was diagnosed in 37.3% of cases, including perioperative stroke in 3.6% of cases. In cases of aortic stenosis, the frequency of perioperative stroke was 9.5%. The cardioembolic subtype of perioperative ischemic stroke in cardiac valve surgery was most likely. The risk factors of the symptomatic delirium of the early postoperative period are: age over 75 years, preoperative frontal dysfunction, duration of artificial respiratory care more than 20 hours after the surgery. Conclusion. The results suggest the efficacy of preventive use of cytoflavin for reducing the frequency and severity of perioperative stroke and symptomatic delirium of the early postoperative period in heart valve surgery with cardiopulmonary bypass. © 2018, Media Sphera Publishing Group. All Rights Reserved.},\\r\\nauthor_keywords={Cardiopulmonary bypass;  Cytoflavin;  Delayed cognitive impairment;  Heart valve surgery;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},\\r\\npublisher={Media Sphera Publishing Group},\\r\\nissn={19977298},\\r\\npubmed_id={29863693},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Tsygan, N.\",\"Andreev, R.\",\"Peleshok, A.\",\"Kolomentsev, S.\",\"Yakovleva, V.\",\"Ryabtsev, A.\",\"Gumennaya, M.\",\"Litvinenko, I.\"],\"key\":\"Tsygan201852\",\"id\":\"Tsygan201852\",\"bibbaseid\":\"tsygan-andreev-peleshok-kolomentsev-yakovleva-ryabtsev-gumennaya-litvinenko-perioperativestrokeinheartvalvesurgerypathogenesisclinicalfindingsdiagnosispreventiontreatment-2018\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&doi=10.17116%2fjnevro20181184152-60&partnerID=40&md5=131b0d4388095a7f8bbc47747a3505af\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Shtam\"],\"firstnames\":[\"T.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Samsonov\"],\"firstnames\":[\"R.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Volnitskiy\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kamyshinsky\"],\"firstnames\":[\"R.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kniazeva\"],\"firstnames\":[\"M.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Korobkina\"],\"firstnames\":[\"E.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Orehov\"],\"firstnames\":[\"A.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Konevega\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Malek\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]}],\"title\":\"Isolation of extracellular micro-vesicles from cell culture medium: Comparative evaluation of methods\",\"journal\":\"Biomeditsinskaya Khimiya\",\"year\":\"2018\",\"volume\":\"64\",\"number\":\"1\",\"pages\":\"23-30\",\"doi\":\"10.18097/PBMC20186401023\",\"note\":\"cited By 1\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&doi=10.18097%2fPBMC20186401023&partnerID=40&md5=b472419d6f68dab8bffc8f53af96f345\",\"affiliation\":\"Petersburg Nuclear Physics Institute of National Research Centre 'Kurchatov Institute', Saint-Petersburg, Gatchina, 188300, Russian Federation; 'Oncosystem' Ltd., Skolkovo, 143026, Russian Federation; N.N.Petrov National Medical Research Center of Oncology, Saint-Petersburg, 197758, Russian Federation; National Research Center 'Kurchatov Institute', Moscow, 123182, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, 195251, Russian Federation\",\"abstract\":\"Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by \\\"horizontal\\\" exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional features of the EV is being commonly studies in in vitro condition. Several methods of EV isolation from cell culture medium are established, however selection of method might influence on obtained results. The choice of the optimal method depends usually from the amount of medium and the aims of the research while is still challenging issue. We performed a comparative analysis of four different methods of EV isolation from cell culture medium: differential ultracentrifugation, ultracentrifugation with a 30% sucrose/D2O \\\"cushion\\\", precipitation with plant proteins and immune-affinity capturing. EV isolated by different approaches were compared in terms of following parameters: size, concentration, morphology of EV, contamination by non-vesicular particles, content of exosomal tetraspanins on the EV surface, content of total proteins, RNA, and several glioma-associated miRNAs. Applied methods included nano-patricle tracking analysis (NTA), dynamic light scattering (DLS), cryo-electron microscopy, flow cytometry and RT-qPCR. On the base of obtained results, we developed practical recommendations that may help researchers to make a best choice of EV isolation method. © 2018 Russian Academy of Medical Sciences. All rights reserved.\",\"author_keywords\":\"Exsosomes; Extracellular vesicles; Immunoprecipitation; Lectines; Methods of isolation; Ultracentrifugation\",\"correspondence_address1\":\"Shtam, T.A.; Petersburg Nuclear Physics Institute of National Research Centre 'Kurchatov Institute'Russian Federation; email: tatyana_shtam@mail.ru\",\"publisher\":\"Russian Academy of Medical Sciences\",\"issn\":\"23106905\",\"pubmed_id\":\"29460831\",\"language\":\"Russian\",\"abbrev_source_title\":\"Biomeditsinskaya Khim.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Shtam201823,\\r\\nauthor={Shtam, T.A. and Samsonov, R.A. and Volnitskiy, A.V. and Kamyshinsky, R.A. and Verlov, N.A. and Kniazeva, M.S. and Korobkina, E.A. and Orehov, A.S. and Vasiliev, A.L. and Konevega, A.L. and Malek, A.V.},\\r\\ntitle={Isolation of extracellular micro-vesicles from cell culture medium: Comparative evaluation of methods},\\r\\njournal={Biomeditsinskaya Khimiya},\\r\\nyear={2018},\\r\\nvolume={64},\\r\\nnumber={1},\\r\\npages={23-30},\\r\\ndoi={10.18097/PBMC20186401023},\\r\\nnote={cited By 1},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&doi=10.18097%2fPBMC20186401023&partnerID=40&md5=b472419d6f68dab8bffc8f53af96f345},\\r\\naffiliation={Petersburg Nuclear Physics Institute of National Research Centre 'Kurchatov Institute', Saint-Petersburg, Gatchina, 188300, Russian Federation; 'Oncosystem' Ltd., Skolkovo, 143026, Russian Federation; N.N.Petrov National Medical Research Center of Oncology, Saint-Petersburg, 197758, Russian Federation; National Research Center 'Kurchatov Institute', Moscow, 123182, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, 195251, Russian Federation},\\r\\nabstract={Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by \\\"horizontal\\\" exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional features of the EV is being commonly studies in in vitro condition. Several methods of EV isolation from cell culture medium are established, however selection of method might influence on obtained results. The choice of the optimal method depends usually from the amount of medium and the aims of the research while is still challenging issue. We performed a comparative analysis of four different methods of EV isolation from cell culture medium: differential ultracentrifugation, ultracentrifugation with a 30% sucrose/D2O \\\"cushion\\\", precipitation with plant proteins and immune-affinity capturing. EV isolated by different approaches were compared in terms of following parameters: size, concentration, morphology of EV, contamination by non-vesicular particles, content of exosomal tetraspanins on the EV surface, content of total proteins, RNA, and several glioma-associated miRNAs. Applied methods included nano-patricle tracking analysis (NTA), dynamic light scattering (DLS), cryo-electron microscopy, flow cytometry and RT-qPCR. On the base of obtained results, we developed practical recommendations that may help researchers to make a best choice of EV isolation method. © 2018 Russian Academy of Medical Sciences. All rights reserved.},\\r\\nauthor_keywords={Exsosomes;  Extracellular vesicles;  Immunoprecipitation;  Lectines;  Methods of isolation;  Ultracentrifugation},\\r\\ncorrespondence_address1={Shtam, T.A.; Petersburg Nuclear Physics Institute of National Research Centre 'Kurchatov Institute'Russian Federation; email: tatyana_shtam@mail.ru},\\r\\npublisher={Russian Academy of Medical Sciences},\\r\\nissn={23106905},\\r\\npubmed_id={29460831},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Biomeditsinskaya Khim.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Shtam, T.\",\"Samsonov, R.\",\"Volnitskiy, A.\",\"Kamyshinsky, R.\",\"Verlov, N.\",\"Kniazeva, M.\",\"Korobkina, E.\",\"Orehov, A.\",\"Vasiliev, A.\",\"Konevega, A.\",\"Malek, A.\"],\"key\":\"Shtam201823\",\"id\":\"Shtam201823\",\"bibbaseid\":\"shtam-samsonov-volnitskiy-kamyshinsky-verlov-kniazeva-korobkina-orehov-etal-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&doi=10.18097%2fPBMC20186401023&partnerID=40&md5=b472419d6f68dab8bffc8f53af96f345\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":0,\"html\":\"\"},{\"bibtype\":\"conference\",\"type\":\"conference\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Shtam\"],\"firstnames\":[\"T.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Samsonov\"],\"firstnames\":[\"R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kamyshinsky\"],\"firstnames\":[\"R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pantina\"],\"firstnames\":[\"R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Konevega\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Malek\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]}],\"title\":\"Exosomes: Some approaches to cancer diagnosis and therapy\",\"journal\":\"AIP Conference Proceedings\",\"year\":\"2017\",\"volume\":\"1882\",\"doi\":\"10.1063/1.5001645\",\"art_number\":\"020066\",\"note\":\"cited By 5; Conference of International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 ; Conference Date: 23 May 2017 Through 26 May 2017; Conference Code:133914\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&doi=10.1063%2f1.5001645&partnerID=40&md5=d908b66243d4ade3a27c45bad492f886\",\"affiliation\":\"Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov Institute, Gatchina, Russian Federation; Petrov Institute of Oncology, Saint-Petersburg, Russian Federation; Ltd. Oncosystem, Skolkovo, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, Russian Federation; National Research Center, Kurchatov Institute, Moscow, Russian Federation\",\"abstract\":\"Exosomes are membrane-bound, intercellular communication shuttle vesicles that are defined by their endocytic origin and size range of 30-120 nm. Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive tool in identifying cancer biomarkers and exploiting exosomes for therapy. In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. Here, we present the possibility of carrying the exogenous p53 protein by exosomes in vitro. © 2017 Author(s).\",\"correspondence_address1\":\"Shtam, T.; Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov InstituteRussian Federation; email: tatyana_shtam@mail.ru\",\"editor\":[{\"propositions\":[],\"lastnames\":[\"Gutmanas\",\"E.Y.\"],\"firstnames\":[\"Naimark\",\"O.B.\"],\"suffixes\":[]}],\"sponsors\":\"Institute of Continuous Media Mechanics of UrB RAS; Institute of Strength Physics and Materials Science of SB RAS; National Research Tomsk Polytechnic University; National Research Tomsk State University; Tomsk Research Institute of Oncology\",\"publisher\":\"American Institute of Physics Inc.\",\"issn\":\"0094243X\",\"isbn\":\"9780735415621\",\"language\":\"English\",\"abbrev_source_title\":\"AIP Conf. Proc.\",\"document_type\":\"Conference Paper\",\"source\":\"Scopus\",\"bibtex\":\"@CONFERENCE{Shtam2017,\\r\\nauthor={Shtam, T. and Samsonov, R. and Kamyshinsky, R. and Pantina, R. and Verlov, N. and Vasiliev, A. and Konevega, A.L. and Malek, A.V.},\\r\\ntitle={Exosomes: Some approaches to cancer diagnosis and therapy},\\r\\njournal={AIP Conference Proceedings},\\r\\nyear={2017},\\r\\nvolume={1882},\\r\\ndoi={10.1063/1.5001645},\\r\\nart_number={020066},\\r\\nnote={cited By 5; Conference of International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 ; Conference Date: 23 May 2017 Through 26 May 2017;  Conference Code:133914},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&doi=10.1063%2f1.5001645&partnerID=40&md5=d908b66243d4ade3a27c45bad492f886},\\r\\naffiliation={Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov Institute, Gatchina, Russian Federation; Petrov Institute of Oncology, Saint-Petersburg, Russian Federation; Ltd. Oncosystem, Skolkovo, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, Russian Federation; National Research Center, Kurchatov Institute, Moscow, Russian Federation},\\r\\nabstract={Exosomes are membrane-bound, intercellular communication shuttle vesicles that are defined by their endocytic origin and size range of 30-120 nm. Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive tool in identifying cancer biomarkers and exploiting exosomes for therapy. In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. Here, we present the possibility of carrying the exogenous p53 protein by exosomes in vitro. © 2017 Author(s).},\\r\\ncorrespondence_address1={Shtam, T.; Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov InstituteRussian Federation; email: tatyana_shtam@mail.ru},\\r\\neditor={Gutmanas E.Y., Naimark O.B., Sharkeev Y.P.},\\r\\nsponsors={Institute of Continuous Media Mechanics of UrB RAS; Institute of Strength Physics and Materials Science of SB RAS; National Research Tomsk Polytechnic University; National Research Tomsk State University; Tomsk Research Institute of Oncology},\\r\\npublisher={American Institute of Physics Inc.},\\r\\nissn={0094243X},\\r\\nisbn={9780735415621},\\r\\nlanguage={English},\\r\\nabbrev_source_title={AIP Conf. Proc.},\\r\\ndocument_type={Conference Paper},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Shtam, T.\",\"Samsonov, R.\",\"Kamyshinsky, R.\",\"Pantina, R.\",\"Verlov, N.\",\"Vasiliev, A.\",\"Konevega, A.\",\"Malek, A.\"],\"editor_short\":[\"Gutmanas E.Y., N. O.\"],\"key\":\"Shtam2017\",\"id\":\"Shtam2017\",\"bibbaseid\":\"shtam-samsonov-kamyshinsky-pantina-verlov-vasiliev-konevega-malek-exosomessomeapproachestocancerdiagnosisandtherapy-2017\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&doi=10.1063%2f1.5001645&partnerID=40&md5=d908b66243d4ade3a27c45bad492f886\"},\"metadata\":{\"authorlinks\":{}},\"downloads\":1,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Stupin\"],\"firstnames\":[\"D.D.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Koniakhin\"],\"firstnames\":[\"S.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Dubina\"],\"firstnames\":[\"M.V.\"],\"suffixes\":[]}],\"title\":\"Adaptive Filtering to Enhance Noise Immunity of Impedance and Admittance Spectroscopy: Comparison with Fourier Transformation\",\"journal\":\"Physical Review Applied\",\"year\":\"2017\",\"volume\":\"7\",\"number\":\"5\",\"doi\":\"10.1103/PhysRevApplied.7.054024\",\"art_number\":\"054024\",\"note\":\"cited By 8\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&doi=10.1103%2fPhysRevApplied.7.054024&partnerID=40&md5=58dc07671359acd5a9cf7852835d8eba\",\"affiliation\":\"St. Petersburg Academic University, Khlopina 8/3, St. Petersburg, 194021, Russian Federation; Petersburg Nuclear Physics Institute NRC Kurchatov Institute, Gatchina, St. Petersburg, 188300, Russian Federation; Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya str. 29, St. Petersburg, 195251, Russian Federation\",\"abstract\":\"The time-domain technique for impedance spectroscopy consists of computing the excitation voltage and current response Fourier images by fast or discrete Fourier transformation and calculating their relation. Here we propose an alternative method for excitation voltage and current response processing for deriving a system impedance spectrum based on a fast and flexible adaptive filtering method. We show the equivalence between the problem of adaptive filter learning and deriving the system impedance spectrum. To be specific, we express the impedance via the adaptive filter weight coefficients. The noise-canceling property of adaptive filtering is also justified. Using the RLC circuit as a model system, we experimentally show that adaptive filtering yields correct admittance spectra and elements ratings in the high-noise conditions when the Fourier-transform technique fails. Providing the additional sensitivity of impedance spectroscopy, adaptive filtering can be applied to otherwise impossible-to-interpret time-domain impedance data. The advantages of adaptive filtering are justified with practical living-cell impedance measurements. © 2017 American Physical Society.\",\"publisher\":\"American Physical Society\",\"issn\":\"23317019\",\"language\":\"English\",\"abbrev_source_title\":\"Phys. Rev. Appl.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Stupin2017,\\r\\nauthor={Stupin, D.D. and Koniakhin, S.V. and Verlov, N.A. and Dubina, M.V.},\\r\\ntitle={Adaptive Filtering to Enhance Noise Immunity of Impedance and Admittance Spectroscopy: Comparison with Fourier Transformation},\\r\\njournal={Physical Review Applied},\\r\\nyear={2017},\\r\\nvolume={7},\\r\\nnumber={5},\\r\\ndoi={10.1103/PhysRevApplied.7.054024},\\r\\nart_number={054024},\\r\\nnote={cited By 8},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&doi=10.1103%2fPhysRevApplied.7.054024&partnerID=40&md5=58dc07671359acd5a9cf7852835d8eba},\\r\\naffiliation={St. Petersburg Academic University, Khlopina 8/3, St. Petersburg, 194021, Russian Federation; Petersburg Nuclear Physics Institute NRC Kurchatov Institute, Gatchina, St. Petersburg, 188300, Russian Federation; Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya str. 29, St. Petersburg, 195251, Russian Federation},\\r\\nabstract={The time-domain technique for impedance spectroscopy consists of computing the excitation voltage and current response Fourier images by fast or discrete Fourier transformation and calculating their relation. Here we propose an alternative method for excitation voltage and current response processing for deriving a system impedance spectrum based on a fast and flexible adaptive filtering method. We show the equivalence between the problem of adaptive filter learning and deriving the system impedance spectrum. To be specific, we express the impedance via the adaptive filter weight coefficients. The noise-canceling property of adaptive filtering is also justified. Using the RLC circuit as a model system, we experimentally show that adaptive filtering yields correct admittance spectra and elements ratings in the high-noise conditions when the Fourier-transform technique fails. Providing the additional sensitivity of impedance spectroscopy, adaptive filtering can be applied to otherwise impossible-to-interpret time-domain impedance data. The advantages of adaptive filtering are justified with practical living-cell impedance measurements. © 2017 American Physical Society.},\\r\\npublisher={American Physical Society},\\r\\nissn={23317019},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Phys. Rev. Appl.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Stupin, D.\",\"Koniakhin, S.\",\"Verlov, N.\",\"Dubina, M.\"],\"key\":\"Stupin2017\",\"id\":\"Stupin2017\",\"bibbaseid\":\"stupin-koniakhin-verlov-dubina-adaptivefilteringtoenhancenoiseimmunityofimpedanceandadmittancespectroscopycomparisonwithfouriertransformation-2017\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&doi=10.1103%2fPhysRevApplied.7.054024&partnerID=40&md5=58dc07671359acd5a9cf7852835d8eba\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Derkach\"],\"firstnames\":[\"K.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bondareva\"],\"firstnames\":[\"V.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chistyakova\"],\"firstnames\":[\"O.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shpakov\"],\"firstnames\":[\"A.O.\"],\"suffixes\":[]}],\"title\":\"Metabolic and hormonal indices in rats with a prolonged model of the metabolic syndrome induced by a high-carbohydrate and high-fat diet\",\"journal\":\"Advances in Gerontology\",\"year\":\"2017\",\"volume\":\"7\",\"number\":\"2\",\"pages\":\"130-136\",\"doi\":\"10.1134/S2079057017020035\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&doi=10.1134%2fS2079057017020035&partnerID=40&md5=d87870b22f7bf0c1ea94f6adc3d657af\",\"affiliation\":\"Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russian Federation\",\"abstract\":\"To develop approaches for the prevention and treatment of the metabolic syndrome (MS), a pathological state widespread in the modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of the MS are required. One of these models is induced by the consumption of a combined high-carbohydrate and high-fat (HC/HF) diet. However, the character, temporal dynamics and severity of the metabolic abnormalities in MS induced by the HC/HF diet are still poorly understood. The aim of this work was to characterize the metabolic changes in Wistar rats with the MS induced by a 10- and 15-week HC/HF diet which included the consumption of a 30% sucrose solution (instead of drinking water) and food rich in saturated fats. The rats which received the HC/HF diet for 15 weeks had a number of features characteristic of the MS such as increased body mass and a specific content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system, hyperhomocysteinemia, a reduced level of nitric oxide and increased concentration of endothelin-1. In the rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of a 10-week duration of the HC/HF diet for the MS induction. Thus, the model of the MS induced by a 15-week HC/HF diet has the characteristic features which allow for extrapolation of the obtained data to similar pathologic changes in humans, and can be used in the study of the etiology and pathogenesis of the MS and in the search for effective ways of MS prevention and treatment. © 2017, Pleiades Publishing, Ltd.\",\"author_keywords\":\"biomodelling; dyslipidemia; endothelial dysfunction; glucose tolerance; high-carbohydrate and high-fat diet; insulin resistance; metabolic syndrome\",\"correspondence_address1\":\"Derkach, K.V.; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of SciencesRussian Federation; email: derkatch_k@list.ru\",\"publisher\":\"Maik Nauka Publishing / Springer SBM\",\"issn\":\"20790570\",\"language\":\"English\",\"abbrev_source_title\":\"Adv. Gerontol.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Derkach2017130,\\r\\nauthor={Derkach, K.V. and Bondareva, V.M. and Trashkov, A.P. and Chistyakova, O.V. and Verlov, N.A. and Shpakov, A.O.},\\r\\ntitle={Metabolic and hormonal indices in rats with a prolonged model of the metabolic syndrome induced by a high-carbohydrate and high-fat diet},\\r\\njournal={Advances in Gerontology},\\r\\nyear={2017},\\r\\nvolume={7},\\r\\nnumber={2},\\r\\npages={130-136},\\r\\ndoi={10.1134/S2079057017020035},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&doi=10.1134%2fS2079057017020035&partnerID=40&md5=d87870b22f7bf0c1ea94f6adc3d657af},\\r\\naffiliation={Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russian Federation},\\r\\nabstract={To develop approaches for the prevention and treatment of the metabolic syndrome (MS), a pathological state widespread in the modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of the MS are required. One of these models is induced by the consumption of a combined high-carbohydrate and high-fat (HC/HF) diet. However, the character, temporal dynamics and severity of the metabolic abnormalities in MS induced by the HC/HF diet are still poorly understood. The aim of this work was to characterize the metabolic changes in Wistar rats with the MS induced by a 10- and 15-week HC/HF diet which included the consumption of a 30% sucrose solution (instead of drinking water) and food rich in saturated fats. The rats which received the HC/HF diet for 15 weeks had a number of features characteristic of the MS such as increased body mass and a specific content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system, hyperhomocysteinemia, a reduced level of nitric oxide and increased concentration of endothelin-1. In the rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of a 10-week duration of the HC/HF diet for the MS induction. Thus, the model of the MS induced by a 15-week HC/HF diet has the characteristic features which allow for extrapolation of the obtained data to similar pathologic changes in humans, and can be used in the study of the etiology and pathogenesis of the MS and in the search for effective ways of MS prevention and treatment. © 2017, Pleiades Publishing, Ltd.},\\r\\nauthor_keywords={biomodelling;  dyslipidemia;  endothelial dysfunction;  glucose tolerance;  high-carbohydrate and high-fat diet;  insulin resistance;  metabolic syndrome},\\r\\ncorrespondence_address1={Derkach, K.V.; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of SciencesRussian Federation; email: derkatch_k@list.ru},\\r\\npublisher={Maik Nauka Publishing / Springer SBM},\\r\\nissn={20790570},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Adv. Gerontol.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Derkach, K.\",\"Bondareva, V.\",\"Trashkov, A.\",\"Chistyakova, O.\",\"Verlov, N.\",\"Shpakov, A.\"],\"key\":\"Derkach2017130\",\"id\":\"Derkach2017130\",\"bibbaseid\":\"derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithaprolongedmodelofthemetabolicsyndromeinducedbyahighcarbohydrateandhighfatdiet-2017\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&doi=10.1134%2fS2079057017020035&partnerID=40&md5=d87870b22f7bf0c1ea94f6adc3d657af\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Bekusova\"],\"firstnames\":[\"V.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Patsanovskii\"],\"firstnames\":[\"V.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Nozdrachev\"],\"firstnames\":[\"A.D.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Artemenko\"],\"firstnames\":[\"M.R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Anisimov\"],\"firstnames\":[\"V.N.\"],\"suffixes\":[]}],\"title\":\"Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats\",\"journal\":\"Cancer Biology and Medicine\",\"year\":\"2017\",\"volume\":\"14\",\"number\":\"1\",\"pages\":\"100-107\",\"doi\":\"10.20892/j.issn.2095-3941.2016.0088\",\"note\":\"cited By 4\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131496&doi=10.20892%2fj.issn.2095-3941.2016.0088&partnerID=40&md5=8951bfc8e9f56ba43897dfebdf580413\",\"affiliation\":\"Department of Physiology, St. Petersburg State University, St. Petersburg, 197183, Russian Federation; I.P.Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034, Russian Federation; Department of Experimental Pharmacology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, The Russian Academy of Sciences, St. Petersburg, 194223, Russian Federation; Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, 197758, Russian Federation\",\"abstract\":\"Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulinlike growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer. Copyright © 2017 by Cancer Biology & Medicine.\",\"author_keywords\":\"1,2-dimethylhydrazine; Colon cancer; Metformin; Prevention; Rat\",\"funding_details\":\"Российский Фонд Фундаментальных Исследований (РФФИ)14-04-01653\",\"key\":\"Bekusova2017100\",\"id\":\"Bekusova2017100\",\"bibbaseid\":\"anonymous-metforminpreventshormonalandmetabolicdisturbancesand12dimethylhydrazineinducedcoloncarcinogenesisinnondiabeticrats-2017\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131496&doi=10.20892%2fj.issn.2095-3941.2016.0088&partnerID=40&md5=8951bfc8e9f56ba43897dfebdf580413\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Derkach\"],\"firstnames\":[\"K.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Bondareva\"],\"firstnames\":[\"V.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chistyakova\"],\"firstnames\":[\"O.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shpakov\"],\"firstnames\":[\"A.O.\"],\"suffixes\":[]}],\"title\":\"Metabolic and hormonal indices in rats with prolonged model of metabolic syndrome induced by high-carbohydrate and high-fat diet\",\"journal\":\"Advances in gerontology = Uspekhi gerontologii\",\"year\":\"2017\",\"volume\":\"30\",\"number\":\"1\",\"pages\":\"31-38\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&partnerID=40&md5=b0a1e874778d13e5a015e02345df4028\",\"affiliation\":\"I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, Saint-Petersburg, 194223, Russian Federation; derkatch_k@list.ru\",\"abstract\":\"To develop the approaches for the prevention and treatment of metabolic syndrome (MS), a pathological state widespread in modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of MS are required. One of these models is induced by the consumption of combined high-carbohydrate and high-fat (HC/HF) diet consisting of excess amount of easily digestible carbohydrates and saturated fats. At the same time, the character, temporal dynamics and severity of metabolic abnormalities in MS induced by HC/HF diet are still poorly understood. The aim of work was the characterization of metabolic changes in Wistar rats with MS induced by 10- and 15-week HC/HF diet that includes the consumption of 30% sucrose solution (instead of drinking water) and food rich in saturated fats. Rats that received HC/HF diet for 15 weeks had a number of features characteristic of MS, such as increased body weight and content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system (hyperhomocysteinemia, the reduced level of vasodilator nitric oxide, the increased concentration of vasoconstrictor endothelin 1). In rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of 10-week duration of HC/HF diet for MS induction. Thus, the model of MS induced by 15-week HC/HF diet has the characteristic features that allow for extrapolation of the obtained data to similar pathologic changes in human, and can be used to study the etiology and pathogenesis of MS and the search of effective ways of MS prevention and treatment. Для разработки методов профилактики и лечения метаболического синдрома (МС), необходимы адекватные его модели на животных. Одна из таких моделей индуцируется потреблением комбинированного высокоуглеводного и высокожирового (ВУ/ВЖ) рациона. Однако характер, динамика во времени и степень тяжести метаболических нарушений при индукции МС с помощью ВУ/ВЖ диеты остаются мало изученными. Цель работы состояла в характеристике метаболических изменений в организме крыс линии Wistar с МС, вызванным 10- и 15-недельной ВУ/ВЖ диетой, которая включала потребление 30 % раствора сахарозы (вместо питьевой воды) и пищи, обогащенной насыщенными жирами. У крыс, получавших ВУ/ВЖ диету в течение 15 нед, отмечали признаки, характерные для МС, — повышение массы тела и удельного содержания абдоминального жира, гипергликемию, гиперинсулинемию, нарушенную толерантность к глюкозе, инсулиновую резистентность, дислипидемию, а также — маркеры нарушений функции сердечно-сосудистой системы — гипергомоцистеинемию, снижение уровня оксида азота и повышение концентрации эндотелина-1. У крыс, находящихся на диете в течение 10 нед, метаболические нарушения были выражены намного слабее, что указывает на недостаточность данной продолжительности ВУ/ВЖ диеты для индукции МС. Таким образом, модель МС, вызываемая 15-недельной ВУ/ВЖ диетой, имеет характерные признаки, позволяющие проводить экстраполяцию полученных данных на сходные патологические изменения у человека, и может быть использована для изучения этиологии и патогенеза МС и поиска эффективных путей его профилактики и лечения.\",\"author_keywords\":\"biomodeling; dyslipidemia; endothelial dysfunction; glucose tolerance; high-carbohydrate and high-fat diet; insulin resistance; metabolic syndrome\",\"issn\":\"15619125\",\"pubmed_id\":\"28557387\",\"language\":\"Russian\",\"abbrev_source_title\":\"Adv Gerontol\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Derkach201731,\\r\\nauthor={Derkach, K.V. and Bondareva, V.M. and Trashkov, A.P. and Chistyakova, O.V. and Verlov, N.A. and Shpakov, A.O.},\\r\\ntitle={Metabolic and hormonal indices in rats with prolonged model of metabolic syndrome induced by high-carbohydrate and high-fat diet},\\r\\njournal={Advances in gerontology = Uspekhi gerontologii},\\r\\nyear={2017},\\r\\nvolume={30},\\r\\nnumber={1},\\r\\npages={31-38},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&partnerID=40&md5=b0a1e874778d13e5a015e02345df4028},\\r\\naffiliation={I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, Saint-Petersburg, 194223, Russian Federation; derkatch_k@list.ru},\\r\\nabstract={To develop the approaches for the prevention and treatment of metabolic syndrome (MS), a pathological state widespread in modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of MS are required. One of these models is induced by the consumption of combined high-carbohydrate and high-fat (HC/HF) diet consisting of excess amount of easily digestible carbohydrates and saturated fats. At the same time, the character, temporal dynamics and severity of metabolic abnormalities in MS induced by HC/HF diet are still poorly understood. The aim of work was the characterization of metabolic changes in Wistar rats with MS induced by 10- and 15-week HC/HF diet that includes the consumption of 30% sucrose solution (instead of drinking water) and food rich in saturated fats. Rats that received HC/HF diet for 15 weeks had a number of features characteristic of MS, such as increased body weight and content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system (hyperhomocysteinemia, the reduced level of vasodilator nitric oxide, the increased concentration of vasoconstrictor endothelin 1). In rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of 10-week duration of HC/HF diet for MS induction. Thus, the model of MS induced by 15-week HC/HF diet has the characteristic features that allow for extrapolation of the obtained data to similar pathologic changes in human, and can be used to study the etiology and pathogenesis of MS and the search of effective ways of MS prevention and treatment.\\r\\nДля разработки методов профилактики и лечения метаболического синдрома (МС), необходимы адекватные его модели на животных. Одна из таких моделей индуцируется потреблением комбинированного высокоуглеводного и высокожирового (ВУ/ВЖ) рациона. Однако характер, динамика во времени и степень тяжести метаболических нарушений при индукции МС с помощью ВУ/ВЖ диеты остаются мало изученными. Цель работы состояла в характеристике метаболических изменений в организме крыс линии Wistar с МС, вызванным 10- и 15-недельной ВУ/ВЖ диетой, которая включала потребление 30 % раствора сахарозы (вместо питьевой воды) и пищи, обогащенной насыщенными жирами. У крыс, получавших ВУ/ВЖ диету в течение 15 нед, отмечали признаки, характерные для МС, — повышение массы тела и удельного содержания абдоминального жира, гипергликемию, гиперинсулинемию, нарушенную толерантность к глюкозе, инсулиновую резистентность, дислипидемию, а также — маркеры нарушений функции сердечно-сосудистой системы — гипергомоцистеинемию, снижение уровня оксида азота и повышение концентрации эндотелина-1. У крыс, находящихся на диете в течение 10 нед, метаболические нарушения были выражены намного слабее, что указывает на недостаточность данной продолжительности ВУ/ВЖ диеты для индукции МС. Таким образом, модель МС, вызываемая 15-недельной ВУ/ВЖ диетой, имеет характерные признаки, позволяющие проводить экстраполяцию полученных данных на сходные патологические изменения у человека, и может быть использована для изучения этиологии и патогенеза МС и поиска эффективных путей его профилактики и лечения.},\\r\\nauthor_keywords={biomodeling;  dyslipidemia;  endothelial dysfunction;  glucose tolerance;  high-carbohydrate and high-fat diet;  insulin resistance;  metabolic syndrome},\\r\\nissn={15619125},\\r\\npubmed_id={28557387},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Adv Gerontol},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Derkach, K.\",\"Bondareva, V.\",\"Trashkov, A.\",\"Chistyakova, O.\",\"Verlov, N.\",\"Shpakov, A.\"],\"key\":\"Derkach201731\",\"id\":\"Derkach201731\",\"bibbaseid\":\"derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithprolongedmodelofmetabolicsyndromeinducedbyhighcarbohydrateandhighfatdiet-2017\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&partnerID=40&md5=b0a1e874778d13e5a015e02345df4028\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Yanishevsky\"],\"firstnames\":[\"S.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Golokhvastov\"],\"firstnames\":[\"S.Y.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Andreev\"],\"firstnames\":[\"R.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Litvinenko\"],\"firstnames\":[\"I.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Karpova\"],\"firstnames\":[\"O.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yakovleva\"],\"firstnames\":[\"V.A.\"],\"suffixes\":[]}],\"title\":\"Modern strategies of protection of hypoxic-ischemic brain damage\",\"journal\":\"Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova\",\"year\":\"2017\",\"volume\":\"117\",\"number\":\"12\",\"pages\":\"78-86\",\"doi\":\"10.17116/jnevro201711712278-86\",\"note\":\"cited By 1\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&doi=10.17116%2fjnevro201711712278-86&partnerID=40&md5=76c5f916d4b4f14fdb4d0bd05109ba70\",\"affiliation\":\"Kirov Military Medical Academy, St. Petersburg, Russian Federation\",\"abstract\":\"Nowadays, there are two complementary approaches to treatment of patients with ischemic stroke: reperfusion and neuroprotection. The main purpose of neuroprotection is to intervene ischemic cascade at every stage of the pathological process and thus avoid the death of nerve cells and expand the therapeutic window for reperfusion therapy. The use of drugs with neurotrophic, antioxidant and neuroregenerative effects is pathogenically explained at all stages of post stroke rehabilitation. Ethylmethylhydroxypyridine succinate (mexidol) is a derivative of succinic acid with antihypoxic, membrane protective, nootropic, anticonvulsant and sedative action. The majority of researchers confirmed the positive effect of mexidol expressed as the marked regression of neurological deficit and wider opportunities for further early rehabilitation. The results of the randomized double blind multicenter placebo-controlled, parallel-group trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA) were published in 2017. The results of the study showed the best positive dynamics of neurological function recovery in case of timely treatment with mexidol with the following two month therapy. The safety of the long-term use of mexidol was confirmed. © 2017, Media Sphera Publishing Group. All rights reserved.\",\"author_keywords\":\"Acute period; Efficacy of treatment; Neuroprotection; Safety of therapy; Stroke; Succinate\",\"correspondence_address1\":\"Yanishevsky, S.N.; Kirov Military Medical AcademyRussian Federation; email: stasya71@yandex.ru\",\"publisher\":\"Media Sphera Publishing Group\",\"issn\":\"19977298\",\"pubmed_id\":\"29411750\",\"language\":\"Russian\",\"abbrev_source_title\":\"Zh. Nevrologii Psihiatrii im. S.S. Korsakova\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Yanishevsky201778,\\r\\nauthor={Yanishevsky, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Andreev, R.V. and Litvinenko, I.V. and Karpova, O.S. and Yakovleva, V.A.},\\r\\ntitle={Modern strategies of protection of hypoxic-ischemic brain damage},\\r\\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\\r\\nyear={2017},\\r\\nvolume={117},\\r\\nnumber={12},\\r\\npages={78-86},\\r\\ndoi={10.17116/jnevro201711712278-86},\\r\\nnote={cited By 1},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&doi=10.17116%2fjnevro201711712278-86&partnerID=40&md5=76c5f916d4b4f14fdb4d0bd05109ba70},\\r\\naffiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation},\\r\\nabstract={Nowadays, there are two complementary approaches to treatment of patients with ischemic stroke: reperfusion and neuroprotection. The main purpose of neuroprotection is to intervene ischemic cascade at every stage of the pathological process and thus avoid the death of nerve cells and expand the therapeutic window for reperfusion therapy. The use of drugs with neurotrophic, antioxidant and neuroregenerative effects is pathogenically explained at all stages of post stroke rehabilitation. Ethylmethylhydroxypyridine succinate (mexidol) is a derivative of succinic acid with antihypoxic, membrane protective, nootropic, anticonvulsant and sedative action. The majority of researchers confirmed the positive effect of mexidol expressed as the marked regression of neurological deficit and wider opportunities for further early rehabilitation. The results of the randomized double blind multicenter placebo-controlled, parallel-group trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA) were published in 2017. The results of the study showed the best positive dynamics of neurological function recovery in case of timely treatment with mexidol with the following two month therapy. The safety of the long-term use of mexidol was confirmed. © 2017, Media Sphera Publishing Group. All rights reserved.},\\r\\nauthor_keywords={Acute period;  Efficacy of treatment;  Neuroprotection;  Safety of therapy;  Stroke;  Succinate},\\r\\ncorrespondence_address1={Yanishevsky, S.N.; Kirov Military Medical AcademyRussian Federation; email: stasya71@yandex.ru},\\r\\npublisher={Media Sphera Publishing Group},\\r\\nissn={19977298},\\r\\npubmed_id={29411750},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Yanishevsky, S.\",\"Tsygan, N.\",\"Golokhvastov, S.\",\"Andreev, R.\",\"Litvinenko, I.\",\"Karpova, O.\",\"Yakovleva, V.\"],\"key\":\"Yanishevsky201778\",\"id\":\"Yanishevsky201778\",\"bibbaseid\":\"yanishevsky-tsygan-golokhvastov-andreev-litvinenko-karpova-yakovleva-modernstrategiesofprotectionofhypoxicischemicbraindamage-2017\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&doi=10.17116%2fjnevro201711712278-86&partnerID=40&md5=76c5f916d4b4f14fdb4d0bd05109ba70\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Odinak\"],\"firstnames\":[\"M.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Khubulava\"],\"firstnames\":[\"G.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"V.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Peleshok\"],\"firstnames\":[\"A.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Andreev\"],\"firstnames\":[\"R.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kurasov\"],\"firstnames\":[\"E.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Litvinenko\"],\"firstnames\":[\"I.V.\"],\"suffixes\":[]}],\"title\":\"Postoperative cerebral dysfunction\",\"journal\":\"Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova\",\"year\":\"2017\",\"volume\":\"117\",\"number\":\"4\",\"pages\":\"34-39\",\"doi\":\"10.17116/jnevro20171174134-39\",\"note\":\"cited By 3\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&doi=10.17116%2fjnevro20171174134-39&partnerID=40&md5=b6de900a49a34dcf567194a67b4eb6cb\",\"affiliation\":\"Kirov Military Medical Academy, Saint Petersburg, Russian Federation\",\"abstract\":\"Objective. To study the structure, risk factors and methods of prevention of postoperative brain dysfunction on the example of coronary artery bypass surgery with cardiopulmonary bypass. Material and methods. The study included 77 patients who undergone elective coronary artery bypass surgery at the beating heart (22 patients) or with cardiopulmonary bypass (55 patients, including 24 patients, who received cerebroprotective treatment with cytoflavin in the preoperative period). All patients underwent dynamic (pre- and postoperative) neurological, neuropsychological, instrumental examinations. Results. The postoperative cerebral dysfunction was diagnosed in 34 (44,2%) patients. The frequency of the clinical types of postoperative cerebral dysfunction significantly differed: perioperative stroke - 3 (3,9%) cases, symptomatic delirium of the early postoperative period - 11 (14,3%) cases, delayed cognitive impairment - 28 (36,4%) cases. The risk factors of postoperative cerebral dysfunction after the coronary artery bypass surgery with cardiopulmonary bypass were identified. Preventive preoperative use of the neuroprotective drug cytoflavin reduces the severity of delayed cognitive impairment after the coronary artery bypass surgery with cardiopulmonary bypass and has a good safety profile. Conclusion. An analysis of the literature data and the results of our own studies show that postoperative cerebral dysfunction is the nosological entity with various etiological factors, pathogenetic mechanisms and the characteristic clinical types, which has an effect on the outcome of surgical treatment. © 2017, Media Sphera, All rights reserved.\",\"author_keywords\":\"Cytoflavin; Deferred cognitive impairment; Neuroprotection; Perioperative stroke; Postoperative cerebral dysfunction; Symptomatic delirium of the early postoperative period\",\"publisher\":\"Media Sphera Publishing Group\",\"issn\":\"19977298\",\"pubmed_id\":\"28617376\",\"language\":\"Russian\",\"abbrev_source_title\":\"Zh. Nevrologii Psihiatrii im. S.S. Korsakova\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Tsygan201734,\\r\\nauthor={Tsygan, N.V. and Odinak, M.M. and Khubulava, G.G. and Tsygan, V.N. and Peleshok, A.S. and Andreev, R.V. and Kurasov, E.S. and Litvinenko, I.V.},\\r\\ntitle={Postoperative cerebral dysfunction},\\r\\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\\r\\nyear={2017},\\r\\nvolume={117},\\r\\nnumber={4},\\r\\npages={34-39},\\r\\ndoi={10.17116/jnevro20171174134-39},\\r\\nnote={cited By 3},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&doi=10.17116%2fjnevro20171174134-39&partnerID=40&md5=b6de900a49a34dcf567194a67b4eb6cb},\\r\\naffiliation={Kirov Military Medical Academy, Saint Petersburg, Russian Federation},\\r\\nabstract={Objective. To study the structure, risk factors and methods of prevention of postoperative brain dysfunction on the example of coronary artery bypass surgery with cardiopulmonary bypass. Material and methods. The study included 77 patients who undergone elective coronary artery bypass surgery at the beating heart (22 patients) or with cardiopulmonary bypass (55 patients, including 24 patients, who received cerebroprotective treatment with cytoflavin in the preoperative period). All patients underwent dynamic (pre- and postoperative) neurological, neuropsychological, instrumental examinations. Results. The postoperative cerebral dysfunction was diagnosed in 34 (44,2%) patients. The frequency of the clinical types of postoperative cerebral dysfunction significantly differed: perioperative stroke - 3 (3,9%) cases, symptomatic delirium of the early postoperative period - 11 (14,3%) cases, delayed cognitive impairment - 28 (36,4%) cases. The risk factors of postoperative cerebral dysfunction after the coronary artery bypass surgery with cardiopulmonary bypass were identified. Preventive preoperative use of the neuroprotective drug cytoflavin reduces the severity of delayed cognitive impairment after the coronary artery bypass surgery with cardiopulmonary bypass and has a good safety profile. Conclusion. An analysis of the literature data and the results of our own studies show that postoperative cerebral dysfunction is the nosological entity with various etiological factors, pathogenetic mechanisms and the characteristic clinical types, which has an effect on the outcome of surgical treatment. © 2017, Media Sphera, All rights reserved.},\\r\\nauthor_keywords={Cytoflavin;  Deferred cognitive impairment;  Neuroprotection;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},\\r\\npublisher={Media Sphera Publishing Group},\\r\\nissn={19977298},\\r\\npubmed_id={28617376},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Tsygan, N.\",\"Odinak, M.\",\"Khubulava, G.\",\"Tsygan, V.\",\"Peleshok, A.\",\"Andreev, R.\",\"Kurasov, E.\",\"Litvinenko, I.\"],\"key\":\"Tsygan201734\",\"id\":\"Tsygan201734\",\"bibbaseid\":\"tsygan-odinak-khubulava-tsygan-peleshok-andreev-kurasov-litvinenko-postoperativecerebraldysfunction-2017\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&doi=10.17116%2fjnevro20171174134-39&partnerID=40&md5=b6de900a49a34dcf567194a67b4eb6cb\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Valeev\"],\"firstnames\":[\"V.V.\"],\"suffixes\":[]},{\"firstnames\":[],\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kovaleko\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Petrov\"],\"firstnames\":[\"A.U.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]}],\"title\":\"Sodium-L-arginine succinate - a new vasodilating medicine for the treatment and prophylaxis of doxorubicin-induced cardiotoxicity\",\"journal\":\"Patologicheskaia fiziologiia i eksperimental'naia terapiia\",\"year\":\"2016\",\"volume\":\"60\",\"number\":\"4\",\"pages\":\"52-57\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&partnerID=40&md5=16d4946de92f1d75751f52d54696233e\",\"abstract\":\"The purpose: to ascertain possible cardioprotective effect of Sodium-L-arginine Succinate in case of myocardial lesions caused by Doxorubicin in rats. Methods. The effectiveness of the drug was assessed by morphometric and biochemical changes reflecting peroxidation intensity and structural and functional changes in myocardium. Results. Sodium-L-arginine Succinate used for the treatment and prophylaxis of antracyclic cardiomyopathy was demonstrated to decrease Doxorubicin effects lessening cardiomyocytal destruction and the left ventricular dysfunction with myocardial hypertrophy.\",\"issn\":\"00312991\",\"pubmed_id\":\"29244923\",\"language\":\"English\",\"abbrev_source_title\":\"Patol Fiziol Eksp Ter\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Valeev201652,\\r\\nauthor={Valeev, V.V. and Trashkov and Kovaleko, A.L. and Petrov, A.U. and Vasiliev, A.G.},\\r\\ntitle={Sodium-L-arginine succinate - a new vasodilating medicine for the treatment and prophylaxis of doxorubicin-induced cardiotoxicity},\\r\\njournal={Patologicheskaia fiziologiia i eksperimental'naia terapiia},\\r\\nyear={2016},\\r\\nvolume={60},\\r\\nnumber={4},\\r\\npages={52-57},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&partnerID=40&md5=16d4946de92f1d75751f52d54696233e},\\r\\nabstract={The purpose: to ascertain possible cardioprotective effect of Sodium-L-arginine Succinate in case of myocardial lesions caused by Doxorubicin in rats. Methods. The effectiveness of the drug was assessed by morphometric and biochemical changes reflecting peroxidation intensity and structural and functional changes in myocardium. Results. Sodium-L-arginine Succinate used for the treatment and prophylaxis of antracyclic cardiomyopathy was demonstrated to decrease Doxorubicin effects lessening cardiomyocytal destruction and the left ventricular dysfunction with myocardial hypertrophy.},\\r\\nissn={00312991},\\r\\npubmed_id={29244923},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Patol Fiziol Eksp Ter},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Valeev, V.\",\"Trashkov\",\"Kovaleko, A.\",\"Petrov, A.\",\"Vasiliev, A.\"],\"key\":\"Valeev201652\",\"id\":\"Valeev201652\",\"bibbaseid\":\"valeev-trashkov-kovaleko-petrov-vasiliev-sodiumlargininesuccinateanewvasodilatingmedicineforthetreatmentandprophylaxisofdoxorubicininducedcardiotoxicity-2016\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&partnerID=40&md5=16d4946de92f1d75751f52d54696233e\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Panchenko\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Popovich\"],\"firstnames\":[\"I.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Egormin\"],\"firstnames\":[\"P.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yurova\"],\"firstnames\":[\"M.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tyndyk\"],\"firstnames\":[\"M.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gubareva\"],\"firstnames\":[\"E.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Artyukin\"],\"firstnames\":[\"I.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Khaitsev\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Zabezhinski\"],\"firstnames\":[\"M.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Anisimov\"],\"firstnames\":[\"V.N.\"],\"suffixes\":[]}],\"title\":\"Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice\",\"journal\":\"Biogerontology\",\"year\":\"2016\",\"volume\":\"17\",\"number\":\"2\",\"pages\":\"317-324\",\"doi\":\"10.1007/s10522-015-9611-y\",\"note\":\"cited By 3\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&doi=10.1007%2fs10522-015-9611-y&partnerID=40&md5=fc4716a4bfbb936f6387a9fcb505bf7e\",\"affiliation\":\"Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, 197758, Russian Federation; St.Petersburg State Pediatric Medical University, 2, Litovskaya str., St. Petersburg, 194100, Russian Federation\",\"abstract\":\"FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %—800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis. © 2015, Springer Science+Business Media Dordrecht.\",\"author_keywords\":\"Biomarkers of aging; FVB/N mice; HER-2/neu; Life span; Spontaneous carcinogenesis\",\"correspondence_address1\":\"Anisimov, V.N.; Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, Russian Federation; email: aging@mail.ru\",\"publisher\":\"Springer Netherlands\",\"issn\":\"13895729\",\"coden\":\"BIOGC\",\"pubmed_id\":\"26423570\",\"language\":\"English\",\"abbrev_source_title\":\"Biogerontology\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Panchenko2016317,\\r\\nauthor={Panchenko, A.V. and Popovich, I.G. and Trashkov, A.P. and Egormin, P.A. and Yurova, M.N. and Tyndyk, M.L. and Gubareva, E.A. and Artyukin, I.N. and Vasiliev, A.G. and Khaitsev, N.V. and Zabezhinski, M.A. and Anisimov, V.N.},\\r\\ntitle={Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice},\\r\\njournal={Biogerontology},\\r\\nyear={2016},\\r\\nvolume={17},\\r\\nnumber={2},\\r\\npages={317-324},\\r\\ndoi={10.1007/s10522-015-9611-y},\\r\\nnote={cited By 3},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&doi=10.1007%2fs10522-015-9611-y&partnerID=40&md5=fc4716a4bfbb936f6387a9fcb505bf7e},\\r\\naffiliation={Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, 197758, Russian Federation; St.Petersburg State Pediatric Medical University, 2, Litovskaya str., St. Petersburg, 194100, Russian Federation},\\r\\nabstract={FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %—800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis. © 2015, Springer Science+Business Media Dordrecht.},\\r\\nauthor_keywords={Biomarkers of aging;  FVB/N mice;  HER-2/neu;  Life span;  Spontaneous carcinogenesis},\\r\\ncorrespondence_address1={Anisimov, V.N.; Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, Russian Federation; email: aging@mail.ru},\\r\\npublisher={Springer Netherlands},\\r\\nissn={13895729},\\r\\ncoden={BIOGC},\\r\\npubmed_id={26423570},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Biogerontology},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Panchenko, A.\",\"Popovich, I.\",\"Trashkov, A.\",\"Egormin, P.\",\"Yurova, M.\",\"Tyndyk, M.\",\"Gubareva, E.\",\"Artyukin, I.\",\"Vasiliev, A.\",\"Khaitsev, N.\",\"Zabezhinski, M.\",\"Anisimov, V.\"],\"key\":\"Panchenko2016317\",\"id\":\"Panchenko2016317\",\"bibbaseid\":\"panchenko-popovich-trashkov-egormin-yurova-tyndyk-gubareva-artyukin-etal-biomarkersofaginglifespanandspontaneouscarcinogenesisinthewildtypeandher2transgenicfvbnfemalemice-2016\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&doi=10.1007%2fs10522-015-9611-y&partnerID=40&md5=fc4716a4bfbb936f6387a9fcb505bf7e\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Vasllev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kovalenko\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Petrov\"],\"firstnames\":[\"A.Yu.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Valeev\"],\"firstnames\":[\"V.V.\"],\"suffixes\":[]}],\"title\":\"Assessment of specific pharmacologic activity of unifusol on endothelium dysfunction model induced by n-nitro-l-arginine methyl ether\",\"journal\":\"Eksperimental'naya i Klinicheskaya Farmakologiya\",\"year\":\"2016\",\"volume\":\"79\",\"number\":\"11\",\"pages\":\"11-14\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&partnerID=40&md5=18fb70c18a00b0d7533945e24d527a58\",\"affiliation\":\"M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, ul. Maurice Thorez44, St. Petersburg, 194223, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, ul. Bekhtereva 1, St. Petersburg, 192019, Russian Federation\",\"abstract\":\"Specific pharmacologic activity of sodium-L-arginine succinate (unifusol) was studied on endothelium dysfunction model (EDM) in rats. EDM was induced by daily administration of N-nitro-L-arginine methyl ether (L-NAME). The effectiveness of experimental therapy with unifusol was assessed by changes in the arterial pressure level, duration of endothelium-dependent and -independent vasodilation, and the blood concentration of endothelial dysfunction markers including VEGF, NO, endothelin-1 and the number of desquamated endotheliocytes. Administration of unifusol favors correction of blood vessel endothelium state as manifested by normalization of its functional activity and reduction of the apoptosis of endotheliocytes. In addition, the obtained results unambiguously confirm considerable vasodilating and antihypertensive effects of unifusol.\",\"author_keywords\":\"Arterial hypertension; Endothelial dysfunction; Rats; Sodium-L-arginine succinate; Unifusol; Vasodilation\",\"publisher\":\"Izdatel'stvo Meditsina\",\"issn\":\"08692092\",\"pubmed_id\":\"29791109\",\"language\":\"Russian\",\"abbrev_source_title\":\"Eksp. Klinicheskaya Farmakol.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Vasllev201611,\\r\\nauthor={Vasllev, A.G. and Trashkov, A.P. and Verlov, N.A. and Kovalenko, A.L. and Petrov, A.Yu. and Valeev, V.V.},\\r\\ntitle={Assessment of specific pharmacologic activity of unifusol on endothelium dysfunction model induced by n-nitro-l-arginine methyl ether},\\r\\njournal={Eksperimental'naya i Klinicheskaya Farmakologiya},\\r\\nyear={2016},\\r\\nvolume={79},\\r\\nnumber={11},\\r\\npages={11-14},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&partnerID=40&md5=18fb70c18a00b0d7533945e24d527a58},\\r\\naffiliation={M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, ul. Maurice Thorez44, St. Petersburg, 194223, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, ul. Bekhtereva 1, St. Petersburg, 192019, Russian Federation},\\r\\nabstract={Specific pharmacologic activity of sodium-L-arginine succinate (unifusol) was studied on endothelium dysfunction model (EDM) in rats. EDM was induced by daily administration of N-nitro-L-arginine methyl ether (L-NAME). The effectiveness of experimental therapy with unifusol was assessed by changes in the arterial pressure level, duration of endothelium-dependent and -independent vasodilation, and the blood concentration of endothelial dysfunction markers including VEGF, NO, endothelin-1 and the number of desquamated endotheliocytes. Administration of unifusol favors correction of blood vessel endothelium state as manifested by normalization of its functional activity and reduction of the apoptosis of endotheliocytes. In addition, the obtained results unambiguously confirm considerable vasodilating and antihypertensive effects of unifusol.},\\r\\nauthor_keywords={Arterial hypertension;  Endothelial dysfunction;  Rats;  Sodium-L-arginine succinate;  Unifusol;  Vasodilation},\\r\\npublisher={Izdatel'stvo Meditsina},\\r\\nissn={08692092},\\r\\npubmed_id={29791109},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Eksp. Klinicheskaya Farmakol.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Vasllev, A.\",\"Trashkov, A.\",\"Verlov, N.\",\"Kovalenko, A.\",\"Petrov, A.\",\"Valeev, V.\"],\"key\":\"Vasllev201611\",\"id\":\"Vasllev201611\",\"bibbaseid\":\"vasllev-trashkov-verlov-kovalenko-petrov-valeev-assessmentofspecificpharmacologicactivityofunifusolonendotheliumdysfunctionmodelinducedbynnitrolargininemethylether-2016\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&partnerID=40&md5=18fb70c18a00b0d7533945e24d527a58\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Valeev\"],\"firstnames\":[\"V.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kovalenko\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasil'ev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]}],\"title\":\"Pathophysiological and clinical aspects of using L-arginine in cardiology and angiology [Patofiziologicheskie i klinicheskie aspekty primeneniia L-arginina v kardiologii i angiologii]\",\"journal\":\"Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery\",\"year\":\"2016\",\"volume\":\"22\",\"number\":\"3\",\"pages\":\"9-15\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&partnerID=40&md5=0a98563798c83c8637d1362f919aff13\",\"affiliation\":\"Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation; Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation; Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation\",\"abstract\":\"Presented herein is a review of scientific publications dedicated to studying the pharmacodynamics of L-arginine and possibilities of its clinical application. Interest to L-arginine is associated, first of all, with its role as a precursor in endogenous synthesis of nitric oxide (NO), playing an important role in regulation of the functional state of the vascular wall. According to numerous studies, oral and parenteral administration of L-arginine restores endothelial production of NO in such diseases as atherosclerosis, hypertension, type 2 diabetes mellitus, obliterating diseases of arteries of lower extremities. The NO-mediated effect of L-arginine manifests itself in increasing the capability of vessels to dilatation, decreasing blood platelet aggregation, and inhibiting proliferation of smooth muscle cells of vessels. The effect is most pronounced in patients presenting with hypercholesterolaemia and initially decreased reactivity of the blood channel. The mostly pronounced NO-mediated effect of L-arginine is observed in parenteral route of its administration. Prolonged administration of L-arginine slows down progression of atherosclerosis.\",\"issn\":\"10276661\",\"pubmed_id\":\"27626244\",\"language\":\"Russian\",\"abbrev_source_title\":\"Angiol Sosud Khir\",\"document_type\":\"Review\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Valeev20169,\\r\\nauthor={Valeev, V.V. and Trashkov, A.P. and Kovalenko, A.L. and Vasil'ev, A.G.},\\r\\ntitle={Pathophysiological and clinical aspects of using L-arginine in cardiology and angiology [Patofiziologicheskie i klinicheskie aspekty primeneniia L-arginina v kardiologii i angiologii]},\\r\\njournal={Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery},\\r\\nyear={2016},\\r\\nvolume={22},\\r\\nnumber={3},\\r\\npages={9-15},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&partnerID=40&md5=0a98563798c83c8637d1362f919aff13},\\r\\naffiliation={Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation; Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation; Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation},\\r\\nabstract={Presented herein is a review of scientific publications dedicated to studying the pharmacodynamics of L-arginine and possibilities of its clinical application. Interest to L-arginine is associated, first of all, with its role as a precursor in endogenous synthesis of nitric oxide (NO), playing an important role in regulation of the functional state of the vascular wall. According to numerous studies, oral and parenteral administration of L-arginine restores endothelial production of NO in such diseases as atherosclerosis, hypertension, type 2 diabetes mellitus, obliterating diseases of arteries of lower extremities. The NO-mediated effect of L-arginine manifests itself in increasing the capability of vessels to dilatation, decreasing blood platelet aggregation, and inhibiting proliferation of smooth muscle cells of vessels. The effect is most pronounced in patients presenting with hypercholesterolaemia and initially decreased reactivity of the blood channel. The mostly pronounced NO-mediated effect of L-arginine is observed in parenteral route of its administration. Prolonged administration of L-arginine slows down progression of atherosclerosis.},\\r\\nissn={10276661},\\r\\npubmed_id={27626244},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Angiol Sosud Khir},\\r\\ndocument_type={Review},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Valeev, V.\",\"Trashkov, A.\",\"Kovalenko, A.\",\"Vasil'ev, A.\"],\"key\":\"Valeev20169\",\"id\":\"Valeev20169\",\"bibbaseid\":\"valeev-trashkov-kovalenko-vasilev-pathophysiologicalandclinicalaspectsofusinglarginineincardiologyandangiologypatofiziologicheskieiklinicheskieaspektyprimeneniialargininavkardiologiiiangiologii-2016\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&partnerID=40&md5=0a98563798c83c8637d1362f919aff13\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"key\":\"Stel\",\"id\":\"Stel\",\"bibbaseid\":\"anonymous-\",\"role\":\"\",\"urls\":{},\"metadata\":{\"authorlinks\":{\"moore, a\":\"https://www.cl.cam.ac.uk/~awm22/talks.html\",\"powner, m\":\"https://bibbase.org/show?bib=benjaminthoma.github.io%2Fpubs.bib&msg=embed\",\"bergmann, r\":\"https://bibbase.org/show?bib=www.wi2.uni-trier.de/publications/WI2Publikationen.bib&group0=year&css=www.wi2.uni-trier.de/publications/WI2.css&filter=authors:Bergmann\",\"van harmelen, f\":\"https://www.cs.vu.nl/\",\"figueroa, n\":\"https://nbfigueroa.github.io/\",\"sammak, s\":\"https://shervinsammak.github.io/papers/\",\"patel, n\":\"https://niravatgit.github.io/INSPIRELab/publications.html#publications\",\"kouamé, d\":\"https://bibbase.org/show?bib=https%3A%2F%2Fwww.irit.fr%2F%7EDenis.Kouame%2Fwp-content%2Fuploads%2Fsites%2F16%2F2023%2F07%2Fpubli_dk_Juillet2023.bib&commas=true&msg=embed&noBootstrap=1\",\"grossi, g\":\"https://bibbase.org/show?bib=https://homes.di.unimi.it/grossi/Grossi_Giuliano.bib\",\"alexiev, v\":\"https://rawgit2.com/VladimirAlexiev/my/master/index.html\",\"bethard, s\":\"https://bethard.github.io/publications.html\",\"homburg, t\":\"https://situx.github.io/publications/\",\"banzhaf, w\":\"https://cse.msu.edu/~banzhafw/Publications_new.html\",\"gatica, j\":\"https://bibbase.org/show?bib=www2.uca.es%2Fdept%2Fcmat_qinor%2Fnanomat%2Fpeople%2FGatica.bib&groupby=year\",\"edwards, c\":\"https://people.ucsc.edu/\",\"miyagusuku, r\":\"https://www.real.utsunomiya-u.ac.jp/invmap/\",\"stephens-davidowitz, n\":\"https://www.noahsd.com/\",\"kouam�, d\":\"https://bibbase.org/show?bib=https%3A%2F%2Fwww.irit.fr%2F%7EDenis.Kouame%2Fwp-content%2Fuploads%2Fsites%2F16%2F2020%2F08%2Fpubli_dk_pc.bib&msg=embed\",\"lee, u\":\"https://bibbase.org/show?bib=https://dblp.org/pid/172/3208.bib\",\"sohrabi, s\":\"https://www.cs.toronto.edu/~shirin/\",\"mcintire, e\":\"https://predictiveecology.org/publications\",\"mirrazavi salehian, s\":\"https://nbfigueroa.github.io/\",\"monteiro, s\":\"https://sildomar.github.io/publications/\",\"picco, m\":\"https://www.lpthe.jussieu.fr/~picco/pub.html\",\"maranas, c\":\"https://bibbase.org/show?bib=www.maranasgroup.com/pub/maranasgroup.bib\",\"romoli, j\":\"https://www.jacoporomoli.com/publications/\",\"maizel, a\":\"https://www.cos.uni-heidelberg.de/\",\"iovino, l\":\"https://www.ludovicoiovino.it/\",\"keller, a\":\"https://bibbase.org/show?bib=https://www.ccb.uni-saarland.de/wp-content/uploads/2024/11/references.bib_.txt&folding=1\",\"riviere, b\":\"https://bibbase.org/show?bib=https://compm.rice.edu/files/2025/01/publicationsRiviere.bib\",\"beyer, a\":\"https://www.klassphil.hu-berlin.de/de/personen/andrea-beyer\",\"bluestein, d\":\"https://www.bme.stonybrook.edu/labs/dbluestein/Multiscale.html\",\"sabattini, l\":\"https://1760809484-atari-embeds.googleusercontent.com/embeds/16cb204cf3a9d4d223a0a3fd8b0eec5d/inner-frame-minified.html\"}},\"downloads\":9,\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Erkudov\"],\"firstnames\":[\"V.O.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pugovkin\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sergeev\"],\"firstnames\":[\"I.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ievkov\"],\"firstnames\":[\"S.A.\"],\"suffixes\":[]}],\"title\":\"Systemic errors in the estimation of systemic arterial pressure via transfer functions after experimental changes of the circulating blood volume\",\"journal\":\"Patologicheskaia fiziologiia i eksperimental'naia terapiia\",\"year\":\"2016\",\"volume\":\"60\",\"number\":\"1\",\"pages\":\"45-49\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&partnerID=40&md5=6367ac191f1141256d9dbfd57e6f43a1\",\"abstract\":\"The results of the experimental studies reveal the decrease of vascular rigidity with the increase of systemic error of the arterial pressure values estimated via implication of transfer functions following haemorrhage modeling in rats. Compensation of the circulating blood volume by means of dextran infusion resulted in restoration of both vascular rigidity and systemic error of estimated arterial pressure. The results can be put into medical practice as an approach for testing of non-invasive methods in cardiovascular research.\",\"issn\":\"00312991\",\"pubmed_id\":\"29215248\",\"language\":\"Russian\",\"abbrev_source_title\":\"Patol Fiziol Eksp Ter\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Erkudov201645,\\r\\nauthor={Erkudov, V.O. and Pugovkin, A.P. and Verlov, N.A. and Sergeev, I.V. and Ievkov, S.A.},\\r\\ntitle={Systemic errors in the estimation of systemic arterial pressure via transfer functions after experimental changes of the circulating blood volume},\\r\\njournal={Patologicheskaia fiziologiia i eksperimental'naia terapiia},\\r\\nyear={2016},\\r\\nvolume={60},\\r\\nnumber={1},\\r\\npages={45-49},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&partnerID=40&md5=6367ac191f1141256d9dbfd57e6f43a1},\\r\\nabstract={The results of the experimental studies reveal the decrease of vascular rigidity with the increase of systemic error of the arterial pressure values estimated via implication of transfer functions following haemorrhage modeling in rats. Compensation of the circulating blood volume by means of dextran infusion resulted in restoration of both vascular rigidity and systemic error of estimated arterial pressure. The results can be put into medical practice as an approach for testing of non-invasive methods in cardiovascular research.},\\r\\nissn={00312991},\\r\\npubmed_id={29215248},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Patol Fiziol Eksp Ter},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Erkudov, V.\",\"Pugovkin, A.\",\"Verlov, N.\",\"Sergeev, I.\",\"Ievkov, S.\"],\"key\":\"Erkudov201645\",\"id\":\"Erkudov201645\",\"bibbaseid\":\"erkudov-pugovkin-verlov-sergeev-ievkov-systemicerrorsintheestimationofsystemicarterialpressureviatransferfunctionsafterexperimentalchangesofthecirculatingbloodvolume-2016\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&partnerID=40&md5=6367ac191f1141256d9dbfd57e6f43a1\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasil'Ev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kovalenko\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Petrov\"],\"firstnames\":[\"A.Yu.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Valeev\"],\"firstnames\":[\"V.V.\"],\"suffixes\":[]}],\"title\":\"Influence of angioprotector drugs on the efficacy of cytostatic therapy (experimental study)\",\"journal\":\"Eksperimental'naya i Klinicheskaya Farmakologiya\",\"year\":\"2016\",\"volume\":\"79\",\"number\":\"2\",\"pages\":\"34-39\",\"note\":\"cited By 1\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&partnerID=40&md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4\",\"affiliation\":\"St. Petersburg State Pediatric Medical University, Ul. Litovskaya 2, St.-Petersburg, 194100, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, Ul. Bekhtereva 1, St.-Petersburg, 192019, Russian Federation\",\"abstract\":\"The influence of angioprotector and endothelium-protector drugs pentoxifylline and unifuzol as components of supportive therapy on the efficacy of combined cytostatic treatment has been experimentally studied. It is established that pentoxifylline and unifuzol do not affect the antitumor and antimetastatic activity of doxorubicin and cyclophosphan with respect to Pliss lymphosarcoma and Walker 256 carcinosarcoma, and in some cases even potentiate the effect of cytostatic therapy.\",\"author_keywords\":\"Cytostatic therapy; Pentoxifylline; Pliss lymphosarcoma; Succinic acid; Tumor; Unifuzol; Walker 256 carcinosarcoma\",\"publisher\":\"Izdatel'stvo Meditsina\",\"issn\":\"08692092\",\"pubmed_id\":\"27416681\",\"language\":\"Russian\",\"abbrev_source_title\":\"Eksp. Klinicheskaya Farmakol.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Trashkov201634,\\r\\nauthor={Trashkov, A.P. and Vasil'Ev, A.G. and Kovalenko, A.L. and Petrov, A.Yu. and Valeev, V.V.},\\r\\ntitle={Influence of angioprotector drugs on the efficacy of cytostatic therapy (experimental study)},\\r\\njournal={Eksperimental'naya i Klinicheskaya Farmakologiya},\\r\\nyear={2016},\\r\\nvolume={79},\\r\\nnumber={2},\\r\\npages={34-39},\\r\\nnote={cited By 1},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&partnerID=40&md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4},\\r\\naffiliation={St. Petersburg State Pediatric Medical University, Ul. Litovskaya 2, St.-Petersburg, 194100, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, Ul. Bekhtereva 1, St.-Petersburg, 192019, Russian Federation},\\r\\nabstract={The influence of angioprotector and endothelium-protector drugs pentoxifylline and unifuzol as components of supportive therapy on the efficacy of combined cytostatic treatment has been experimentally studied. It is established that pentoxifylline and unifuzol do not affect the antitumor and antimetastatic activity of doxorubicin and cyclophosphan with respect to Pliss lymphosarcoma and Walker 256 carcinosarcoma, and in some cases even potentiate the effect of cytostatic therapy.},\\r\\nauthor_keywords={Cytostatic therapy;  Pentoxifylline;  Pliss lymphosarcoma;  Succinic acid;  Tumor;  Unifuzol;  Walker 256 carcinosarcoma},\\r\\npublisher={Izdatel'stvo Meditsina},\\r\\nissn={08692092},\\r\\npubmed_id={27416681},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Eksp. Klinicheskaya Farmakol.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Trashkov, A.\",\"Vasil'Ev, A.\",\"Kovalenko, A.\",\"Petrov, A.\",\"Valeev, V.\"],\"key\":\"Trashkov201634\",\"id\":\"Trashkov201634\",\"bibbaseid\":\"trashkov-vasilev-kovalenko-petrov-valeev-influenceofangioprotectordrugsontheefficacyofcytostatictherapyexperimentalstudy-2016\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&partnerID=40&md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Odinak\"],\"firstnames\":[\"M.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Voznyuk\"],\"firstnames\":[\"I.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yanishevsky\"],\"firstnames\":[\"S.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Golokhvastov\"],\"firstnames\":[\"S.Y.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Polushin\"],\"firstnames\":[\"A.Yu.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Andreev\"],\"firstnames\":[\"R.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Mirnaya\"],\"firstnames\":[\"D.A.\"],\"suffixes\":[]}],\"title\":\"Opportunities in multimodal neuroimaging for optimizing thrombolytic therapy for ischemic stroke\",\"journal\":\"Nevrologiya, Neiropsikhiatriya, Psikhosomatika\",\"year\":\"2016\",\"volume\":\"8\",\"number\":\"1\",\"pages\":\"9-15\",\"doi\":\"10.14412/2074-2711-2016-1-9-15\",\"note\":\"cited By 1\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&doi=10.14412%2f2074-2711-2016-1-9-15&partnerID=40&md5=f1c8a704d6aab179148bfb1ddbad5891\",\"affiliation\":\"S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg, 6, Academician Lebedev St., Saint Petersburg, 194044, Russian Federation\",\"abstract\":\"The main purpose of examination of patients before thrombolytic therapy for ischemic stroke (IS) is to timely identify contraindications to the use of recombinant tissue plasminogen activator. Objective: to estimate opportunities and benefits in applying multimodal magnetic resonance imaging (MRI) to improve clinical outcomes in acute stroke, among other processes, by enhancing the efficiency and safety of thrombolytic therapy. Patients and methods. The clinical experience of the S.M. Kirov Military Medical Academy in using multimodal MRI of the brain since 2004 was analyzed in patients with stroke. Results. Comprehensive assessment of the results of perfusion-weighted MRI of the brain and those of transcranial Doppler ultrasound identified five clinically significant variants of perfusion changes in IS: normal perfusion; postischemic hyperemia; persistent hypoperfusion; acute pathological hyperperfusion, and unrecovered perfusion. With an irreversible tissue damage volume of &gt;60 cm3 on day 1 of stroke, as evidenced by diffusion-weighted MRI, the odd ratio for cerebral edema in the acutest period of the disease is 39.4% (95% CI 2.57-2436; p&lt;0.05). The risk of hemorrhagic transformation increases with a measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct &lt;35×10-5 mm2/sec within the first 24 hours after disease onset (p&lt;0.005). Conclusion. The data of local clinical practice and the results of international clinical trials show that multimodal MRI of the brain is a reliable tool for the detailed evaluation of the expected efficiency and safety of thrombolytic therapy for IS. When persistent hypoperfusion is detected, the determination of perfusion-diffusion mismatch is of no informative value in deciding on whether thrombolytic therapy can be performed. Estimating the volume of pathological changes on diffusion-weighted images and the measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct in the measured diffusion coefficient maps allows the risk of major intracranial complications due to IS to be identified.\",\"author_keywords\":\"Diffusionweighted magnetic resonance imaging; Intracranial complications due to stroke; Ischemic stroke; Multimodal neuroimaging; Perfusion-weighted magnetic resonance imaging; Thrombolytic therapy; Variants of perfusion changes\",\"correspondence_address1\":\"Yanishevsky, S.N.; S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg, 6, Academician Lebedev St., Russian Federation; email: stasya71@yandex.ru\",\"publisher\":\"Ima-Press Publishing House\",\"issn\":\"20742711\",\"language\":\"Russian\",\"abbrev_source_title\":\"Nevrol. Neiropsikhiatr. Psikhosomat.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Odinak20169,\\r\\nauthor={Odinak, M.M. and Voznyuk, I.A. and Yanishevsky, S.N. and Golokhvastov, S.Y. and Tsygan, N.V. and Polushin, A.Yu. and Andreev, R.V. and Mirnaya, D.A.},\\r\\ntitle={Opportunities in multimodal neuroimaging for optimizing thrombolytic therapy for ischemic stroke},\\r\\njournal={Nevrologiya, Neiropsikhiatriya, Psikhosomatika},\\r\\nyear={2016},\\r\\nvolume={8},\\r\\nnumber={1},\\r\\npages={9-15},\\r\\ndoi={10.14412/2074-2711-2016-1-9-15},\\r\\nnote={cited By 1},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&doi=10.14412%2f2074-2711-2016-1-9-15&partnerID=40&md5=f1c8a704d6aab179148bfb1ddbad5891},\\r\\naffiliation={S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg, 6, Academician Lebedev St., Saint Petersburg, 194044, Russian Federation},\\r\\nabstract={The main purpose of examination of patients before thrombolytic therapy for ischemic stroke (IS) is to timely identify contraindications to the use of recombinant tissue plasminogen activator. Objective: to estimate opportunities and benefits in applying multimodal magnetic resonance imaging (MRI) to improve clinical outcomes in acute stroke, among other processes, by enhancing the efficiency and safety of thrombolytic therapy. Patients and methods. The clinical experience of the S.M. Kirov Military Medical Academy in using multimodal MRI of the brain since 2004 was analyzed in patients with stroke. Results. Comprehensive assessment of the results of perfusion-weighted MRI of the brain and those of transcranial Doppler ultrasound identified five clinically significant variants of perfusion changes in IS: normal perfusion; postischemic hyperemia; persistent hypoperfusion; acute pathological hyperperfusion, and unrecovered perfusion. With an irreversible tissue damage volume of &gt;60 cm3 on day 1 of stroke, as evidenced by diffusion-weighted MRI, the odd ratio for cerebral edema in the acutest period of the disease is 39.4% (95% CI 2.57-2436; p&lt;0.05). The risk of hemorrhagic transformation increases with a measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct &lt;35×10-5 mm2/sec within the first 24 hours after disease onset (p&lt;0.005). Conclusion. The data of local clinical practice and the results of international clinical trials show that multimodal MRI of the brain is a reliable tool for the detailed evaluation of the expected efficiency and safety of thrombolytic therapy for IS. When persistent hypoperfusion is detected, the determination of perfusion-diffusion mismatch is of no informative value in deciding on whether thrombolytic therapy can be performed. Estimating the volume of pathological changes on diffusion-weighted images and the measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct in the measured diffusion coefficient maps allows the risk of major intracranial complications due to IS to be identified.},\\r\\nauthor_keywords={Diffusionweighted magnetic resonance imaging;  Intracranial complications due to stroke;  Ischemic stroke;  Multimodal neuroimaging;  Perfusion-weighted magnetic resonance imaging;  Thrombolytic therapy;  Variants of perfusion changes},\\r\\ncorrespondence_address1={Yanishevsky, S.N.; S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg, 6, Academician Lebedev St., Russian Federation; email: stasya71@yandex.ru},\\r\\npublisher={Ima-Press Publishing House},\\r\\nissn={20742711},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Nevrol. Neiropsikhiatr. Psikhosomat.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Odinak, M.\",\"Voznyuk, I.\",\"Yanishevsky, S.\",\"Golokhvastov, S.\",\"Tsygan, N.\",\"Polushin, A.\",\"Andreev, R.\",\"Mirnaya, D.\"],\"key\":\"Odinak20169\",\"id\":\"Odinak20169\",\"bibbaseid\":\"odinak-voznyuk-yanishevsky-golokhvastov-tsygan-polushin-andreev-mirnaya-opportunitiesinmultimodalneuroimagingforoptimizingthrombolytictherapyforischemicstroke-2016\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&doi=10.14412%2f2074-2711-2016-1-9-15&partnerID=40&md5=f1c8a704d6aab179148bfb1ddbad5891\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Karabanov\"],\"firstnames\":[\"S.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Suvorov\"],\"firstnames\":[\"D.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gololobov\"],\"firstnames\":[\"G.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Slivkin\"],\"firstnames\":[\"E.V.\"],\"suffixes\":[]}],\"title\":\"Properties of contact coatings based on ruthenium nanofilms for MEMS switches\",\"journal\":\"Technical Physics Letters\",\"year\":\"2015\",\"volume\":\"41\",\"number\":\"7\",\"pages\":\"691-693\",\"doi\":\"10.1134/S1063785015070226\",\"note\":\"cited By 2\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&doi=10.1134%2fS1063785015070226&partnerID=40&md5=7efd35505f6a5b7c2f8c867e82b0ac4a\",\"affiliation\":\"Ryazan State Radioengineering University, Ryazan, 390005, Russian Federation\",\"abstract\":\"Switching properties of contact coatings based on ruthenium nanofilms obtained by electrochemical deposition have been studied. The laws of variation of the contact resistance as a function of the number of switching cycles are established as dependent on the coating thickness and surface roughness. Optimum parameters of contact coatings are determined that ensure minimum contact resistance of switches for micro-electromechanical systems (MEMS) operating in steady-state regimes. © 2015, Pleiades Publishing, Ltd.\",\"correspondence_address1\":\"Suvorov, D.V.; Ryazan State Radioengineering UniversityRussian Federation\",\"publisher\":\"Maik Nauka-Interperiodica Publishing\",\"issn\":\"10637850\",\"language\":\"English\",\"abbrev_source_title\":\"Tech. Phys. Lett.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Karabanov2015691,\\r\\nauthor={Karabanov, S.M. and Verlov, N.A. and Suvorov, D.V. and Gololobov, G.P. and Slivkin, E.V.},\\r\\ntitle={Properties of contact coatings based on ruthenium nanofilms for MEMS switches},\\r\\njournal={Technical Physics Letters},\\r\\nyear={2015},\\r\\nvolume={41},\\r\\nnumber={7},\\r\\npages={691-693},\\r\\ndoi={10.1134/S1063785015070226},\\r\\nnote={cited By 2},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&doi=10.1134%2fS1063785015070226&partnerID=40&md5=7efd35505f6a5b7c2f8c867e82b0ac4a},\\r\\naffiliation={Ryazan State Radioengineering University, Ryazan, 390005, Russian Federation},\\r\\nabstract={Switching properties of contact coatings based on ruthenium nanofilms obtained by electrochemical deposition have been studied. The laws of variation of the contact resistance as a function of the number of switching cycles are established as dependent on the coating thickness and surface roughness. Optimum parameters of contact coatings are determined that ensure minimum contact resistance of switches for micro-electromechanical systems (MEMS) operating in steady-state regimes. © 2015, Pleiades Publishing, Ltd.},\\r\\ncorrespondence_address1={Suvorov, D.V.; Ryazan State Radioengineering UniversityRussian Federation},\\r\\npublisher={Maik Nauka-Interperiodica Publishing},\\r\\nissn={10637850},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Tech. Phys. Lett.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Karabanov, S.\",\"Verlov, N.\",\"Suvorov, D.\",\"Gololobov, G.\",\"Slivkin, E.\"],\"key\":\"Karabanov2015691\",\"id\":\"Karabanov2015691\",\"bibbaseid\":\"karabanov-verlov-suvorov-gololobov-slivkin-propertiesofcontactcoatingsbasedonrutheniumnanofilmsformemsswitches-2015\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&doi=10.1134%2fS1063785015070226&partnerID=40&md5=7efd35505f6a5b7c2f8c867e82b0ac4a\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Odinak\"],\"firstnames\":[\"M.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yanishevskii\"],\"firstnames\":[\"S.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Golokhvastov\"],\"firstnames\":[\"S.Y.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Voznyuk\"],\"firstnames\":[\"I.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trufanov\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]}],\"title\":\"Use of Succinates for Correction of Metabolic Impairments in the Ischemic Penumbra Zone in Stroke Patients\",\"journal\":\"Neuroscience and Behavioral Physiology\",\"year\":\"2015\",\"volume\":\"45\",\"number\":\"5\",\"pages\":\"600-604\",\"doi\":\"10.1007/s11055-015-0118-4\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&doi=10.1007%2fs11055-015-0118-4&partnerID=40&md5=985c7310b65123e7f0e76e00e7df1c26\",\"affiliation\":\"Department of Nervous Diseases, Kirov Military Medical Academy, St. Petersburg, Russian Federation\",\"abstract\":\"The aim of the present work was to use MR spectroscopy to assess the quantitative contents and ratios of different metabolites in the infarct nucleus, ischemic penumbra, and unaltered tissue in the opposite hemisphere in patients in the acute period of ischemic stroke. A total of 72 patients were studied, of whom 37 (the study group) received the antioxidant Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) in addition to basal treatment, while 35 patients received only standard treatment without use of antioxidants. Stroke severity was assessed on the NIHSS scale and functional outcomes on day 30 were evaluated using the Bartel index and modified Rankin scale. MR proton spectroscopy was performed twice: during the first 24 h of disease onset and on day 5. Use of the succinate-containing antioxidant Mexidol (500 mg i.v. for 14 days) during the acute period of ischemic stroke significantly decreased the intracellular lactate (p = 0.002) and inositol contents (p = 0.005) from the levels in the control group, which helped restore the balance between the aerobic and anaerobic mechanisms of oxidation and had favorable influences on the rehabilitation potentials of the patients. A positive correlation was found between the lactate content in the ischemic penumbra zone and values on the NIHSS (r = 0.5786, p = 0.049), along with a negative correlation between the lactate content in the ischemic penumbra zone and the level of functional recovery assessed on the Bartel index (r = –0.6305, p = 0.028), which supports the existence of an interaction between impaired glucose metabolism in hypoxic conditions and the level of injury to nervous tissue. © 2015, Springer Science+Business Media New York.\",\"author_keywords\":\"antioxidants; ischemic stroke; magnetic resonance spectroscopy; Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate)\",\"correspondence_address1\":\"Yanishevskii, S.N.; Department of Nervous Diseases, Kirov Military Medical AcademyRussian Federation; email: stasya71@yandex.ru\",\"publisher\":\"Springer New York LLC\",\"issn\":\"00970549\",\"coden\":\"NBHPB\",\"language\":\"English\",\"abbrev_source_title\":\"Neurosci. Behav. Physiol.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Odinak2015600,\\r\\nauthor={Odinak, M.M. and Yanishevskii, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Voznyuk, I.A. and Trufanov, A.G.},\\r\\ntitle={Use of Succinates for Correction of Metabolic Impairments in the Ischemic Penumbra Zone in Stroke Patients},\\r\\njournal={Neuroscience and Behavioral Physiology},\\r\\nyear={2015},\\r\\nvolume={45},\\r\\nnumber={5},\\r\\npages={600-604},\\r\\ndoi={10.1007/s11055-015-0118-4},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&doi=10.1007%2fs11055-015-0118-4&partnerID=40&md5=985c7310b65123e7f0e76e00e7df1c26},\\r\\naffiliation={Department of Nervous Diseases, Kirov Military Medical Academy, St. Petersburg, Russian Federation},\\r\\nabstract={The aim of the present work was to use MR spectroscopy to assess the quantitative contents and ratios of different metabolites in the infarct nucleus, ischemic penumbra, and unaltered tissue in the opposite hemisphere in patients in the acute period of ischemic stroke. A total of 72 patients were studied, of whom 37 (the study group) received the antioxidant Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) in addition to basal treatment, while 35 patients received only standard treatment without use of antioxidants. Stroke severity was assessed on the NIHSS scale and functional outcomes on day 30 were evaluated using the Bartel index and modified Rankin scale. MR proton spectroscopy was performed twice: during the first 24 h of disease onset and on day 5. Use of the succinate-containing antioxidant Mexidol (500 mg i.v. for 14 days) during the acute period of ischemic stroke significantly decreased the intracellular lactate (p = 0.002) and inositol contents (p = 0.005) from the levels in the control group, which helped restore the balance between the aerobic and anaerobic mechanisms of oxidation and had favorable influences on the rehabilitation potentials of the patients. A positive correlation was found between the lactate content in the ischemic penumbra zone and values on the NIHSS (r = 0.5786, p = 0.049), along with a negative correlation between the lactate content in the ischemic penumbra zone and the level of functional recovery assessed on the Bartel index (r = –0.6305, p = 0.028), which supports the existence of an interaction between impaired glucose metabolism in hypoxic conditions and the level of injury to nervous tissue. © 2015, Springer Science+Business Media New York.},\\r\\nauthor_keywords={antioxidants;  ischemic stroke;  magnetic resonance spectroscopy;  Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate)},\\r\\ncorrespondence_address1={Yanishevskii, S.N.; Department of Nervous Diseases, Kirov Military Medical AcademyRussian Federation; email: stasya71@yandex.ru},\\r\\npublisher={Springer New York LLC},\\r\\nissn={00970549},\\r\\ncoden={NBHPB},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Neurosci. Behav. Physiol.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Odinak, M.\",\"Yanishevskii, S.\",\"Tsygan, N.\",\"Golokhvastov, S.\",\"Voznyuk, I.\",\"Trufanov, A.\"],\"key\":\"Odinak2015600\",\"id\":\"Odinak2015600\",\"bibbaseid\":\"odinak-yanishevskii-tsygan-golokhvastov-voznyuk-trufanov-useofsuccinatesforcorrectionofmetabolicimpairmentsintheischemicpenumbrazoneinstrokepatients-2015\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&doi=10.1007%2fs11055-015-0118-4&partnerID=40&md5=985c7310b65123e7f0e76e00e7df1c26\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Panchenko\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kayukova\"],\"firstnames\":[\"E.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Korablev\"],\"firstnames\":[\"R.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Pechatnikova\"],\"firstnames\":[\"V.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasil’ev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Anisimov\"],\"firstnames\":[\"V.N.\"],\"suffixes\":[]}],\"title\":\"P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation\",\"journal\":\"Bulletin of Experimental Biology and Medicine\",\"year\":\"2015\",\"volume\":\"158\",\"number\":\"4\",\"pages\":\"497-499\",\"doi\":\"10.1007/s10517-015-2793-0\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&doi=10.1007%2fs10517-015-2793-0&partnerID=40&md5=aa6957c053dc95e316a5743556578173\",\"affiliation\":\"St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation; N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation\",\"abstract\":\"Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia. © 2015, Springer Science+Business Media New York.\",\"author_keywords\":\"hemostasis; neoangiogenesis; P-388 leukemia; tumor; vascular endothelial growth factor\",\"correspondence_address1\":\"Trashkov, A.P.; St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian FederationRussian Federation; email: alexandr.trashkov@gmail.com\",\"publisher\":\"Springer New York LLC\",\"issn\":\"00074888\",\"coden\":\"BEXBA\",\"pubmed_id\":\"25708334\",\"language\":\"English\",\"abbrev_source_title\":\"Bull. Exp. Biol. Med.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Trashkov2015497,\\r\\nauthor={Trashkov, A.P. and Panchenko, A.V. and Kayukova, E.S. and Korablev, R.V. and Pechatnikova, V.A. and Vasil’ev, A.G. and Anisimov, V.N.},\\r\\ntitle={P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation},\\r\\njournal={Bulletin of Experimental Biology and Medicine},\\r\\nyear={2015},\\r\\nvolume={158},\\r\\nnumber={4},\\r\\npages={497-499},\\r\\ndoi={10.1007/s10517-015-2793-0},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&doi=10.1007%2fs10517-015-2793-0&partnerID=40&md5=aa6957c053dc95e316a5743556578173},\\r\\naffiliation={St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation; N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation},\\r\\nabstract={Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia. © 2015, Springer Science+Business Media New York.},\\r\\nauthor_keywords={hemostasis;  neoangiogenesis;  P-388 leukemia;  tumor;  vascular endothelial growth factor},\\r\\ncorrespondence_address1={Trashkov, A.P.; St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian FederationRussian Federation; email: alexandr.trashkov@gmail.com},\\r\\npublisher={Springer New York LLC},\\r\\nissn={00074888},\\r\\ncoden={BEXBA},\\r\\npubmed_id={25708334},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Bull. Exp. Biol. Med.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Trashkov, A.\",\"Panchenko, A.\",\"Kayukova, E.\",\"Korablev, R.\",\"Pechatnikova, V.\",\"Vasil’ev, A.\",\"Anisimov, V.\"],\"key\":\"Trashkov2015497\",\"id\":\"Trashkov2015497\",\"bibbaseid\":\"trashkov-panchenko-kayukova-korablev-pechatnikova-vasilev-anisimov-p388leukemiaincdf1miceasthetestsystemforstudiesoftumorassociatedneoangiogenesisandhypercoagulation-2015\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&doi=10.1007%2fs10517-015-2793-0&partnerID=40&md5=aa6957c053dc95e316a5743556578173\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yakovleva\"],\"firstnames\":[\"V.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Malkova\"],\"firstnames\":[\"V.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gracheva\"],\"firstnames\":[\"E.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kovalenko\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]}],\"title\":\"Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke\",\"journal\":\"Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova\",\"year\":\"2015\",\"volume\":\"2015\",\"number\":\"7\",\"pages\":\"112-116\",\"doi\":\"10.17116/jnevro201511571112-116\",\"note\":\"cited By 1\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&doi=10.17116%2fjnevro201511571112-116&partnerID=40&md5=d627b1d1e0674d0be3e6fa7af2c09a99\",\"affiliation\":\"Kirov Military Medical Academy, St. Petersburg, Russian Federation; St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation; Institute of Toxicology of the Federal Medical-Biological Agency, St. Petersburg, Russian Federation\",\"abstract\":\"Objective. To explore the endogenous and pharmacological activation of neurotrophic mechanisms in a model of brain ischemic lesion in rats. Material and methods. The study was performed on 170 male albino rats (195-205 g). The model of ischemic stroke was accomplished by the electrocoagulation of the proximal segment of the left middle cerebral artery and simultaneous permanent ligation of the left common carotid artery. Results and conclusion. The evaluation of NSE, NO, VEGF, NGF levels in the brain cytoplasmic lysate and plasma showed the delayed activation of neurotrophic mechanisms in astrocytes accompanied by a decrease in delayed alteration of neurons. The use of cytoflavin in the treatment of stroke was accompanied by the earlier and more intense activation of neurotrophic mechanisms in astrocytes, delayed activation of neurotrophic mechanisms in endothelial cells, which promoted neuroprotection in acute ischemic stroke. © 2015, Media Sphera. All rights reserved.\",\"author_keywords\":\"Cytoflavin; Endothelial dysfunction; Ischemic stroke; Multimodal cytoprotection; Neurotrophic factors; Neurotrophic mechanisms\",\"publisher\":\"Media Sphera\",\"issn\":\"19977298\",\"pubmed_id\":\"26356524\",\"language\":\"Russian\",\"abbrev_source_title\":\"Zh. Nevrologii Psihiatrii im. S.S. Korsakova\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Tsygan2015112,\\r\\nauthor={Tsygan, N.V. and Trashkov, A.P. and Yakovleva, V.A. and Malkova, V.M. and Gracheva, E.V. and Kovalenko, A.L. and Vasiliev, A.G.},\\r\\ntitle={Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke},\\r\\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\\r\\nyear={2015},\\r\\nvolume={2015},\\r\\nnumber={7},\\r\\npages={112-116},\\r\\ndoi={10.17116/jnevro201511571112-116},\\r\\nnote={cited By 1},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&doi=10.17116%2fjnevro201511571112-116&partnerID=40&md5=d627b1d1e0674d0be3e6fa7af2c09a99},\\r\\naffiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation; St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation; Institute of Toxicology of the Federal Medical-Biological Agency, St. Petersburg, Russian Federation},\\r\\nabstract={Objective. To explore the endogenous and pharmacological activation of neurotrophic mechanisms in a model of brain ischemic lesion in rats. Material and methods. The study was performed on 170 male albino rats (195-205 g). The model of ischemic stroke was accomplished by the electrocoagulation of the proximal segment of the left middle cerebral artery and simultaneous permanent ligation of the left common carotid artery. Results and conclusion. The evaluation of NSE, NO, VEGF, NGF levels in the brain cytoplasmic lysate and plasma showed the delayed activation of neurotrophic mechanisms in astrocytes accompanied by a decrease in delayed alteration of neurons. The use of cytoflavin in the treatment of stroke was accompanied by the earlier and more intense activation of neurotrophic mechanisms in astrocytes, delayed activation of neurotrophic mechanisms in endothelial cells, which promoted neuroprotection in acute ischemic stroke. © 2015, Media Sphera. All rights reserved.},\\r\\nauthor_keywords={Cytoflavin;  Endothelial dysfunction;  Ischemic stroke;  Multimodal cytoprotection;  Neurotrophic factors;  Neurotrophic mechanisms},\\r\\npublisher={Media Sphera},\\r\\nissn={19977298},\\r\\npubmed_id={26356524},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Tsygan, N.\",\"Trashkov, A.\",\"Yakovleva, V.\",\"Malkova, V.\",\"Gracheva, E.\",\"Kovalenko, A.\",\"Vasiliev, A.\"],\"key\":\"Tsygan2015112\",\"id\":\"Tsygan2015112\",\"bibbaseid\":\"tsygan-trashkov-yakovleva-malkova-gracheva-kovalenko-vasiliev-characteristicsoftheregulationofneurotrophicmechanismsinischemicstroke-2015\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&doi=10.17116%2fjnevro201511571112-116&partnerID=40&md5=d627b1d1e0674d0be3e6fa7af2c09a99\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Panchenko\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Korablev\"],\"firstnames\":[\"R.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yurova\"],\"firstnames\":[\"M.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Egormin\"],\"firstnames\":[\"P.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chernenko\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Gpopovich\"],\"firstnames\":[\"I.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tyndyk\"],\"firstnames\":[\"M.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Verlov\"],\"firstnames\":[\"N.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Artemenko\"],\"firstnames\":[\"M.R.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Anisimov\"],\"firstnames\":[\"V.N.\"],\"suffixes\":[]}],\"title\":\"Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice\",\"journal\":\"Voprosy Onkologii\",\"year\":\"2015\",\"volume\":\"61\",\"number\":\"4\",\"pages\":\"642-646\",\"note\":\"cited By 1\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&partnerID=40&md5=25700032627eb71d9f9c0243ffa43e26\",\"affiliation\":\"State Pediatric Medical University, Russian Federation; N.N.Petrov Research Institute of Oncology, St.-Petersburg, Russian Federation\",\"abstract\":\"Age-dependent angiogenesis intensity changes have been studied in transgenic HER-2/neu (FBV/N) mice characteristic of breast tumors' high incidence with hyperexpression of HER- 2/neu. Concentration of vascular endothelial growth factor, insulin-dependent growth factor 1, nitrogen monoxide, tissue plasminogen activator and type 1 plasminogen activator inhibitor were assessed by means of immune-enzyme assay. The results testify to angiogenesis processes activation side by side with aging and growth of the tumors. Maximum manifestation of these disturbances (growth factors' blood concentrations increase and endotheliocytes' functional activity inhibition) has been revealed in 6-month-oId mice during neoplasma maximum intensive and aggressive growth period.\",\"author_keywords\":\"Age-dependent changes; Angiogenesis; Biomodeling; Breast tumors; Hemostasis; HER- 2/neu; IGF-1; PAI-1; TPA; VEGF\",\"publisher\":\"Izdatel'stvo Meditsina\",\"issn\":\"05073758\",\"coden\":\"VOONA\",\"pubmed_id\":\"26571837\",\"language\":\"Russian\",\"abbrev_source_title\":\"Vopr. Onkol.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Trashkov2015642,\\r\\nauthor={Trashkov, A.P. and Panchenko, A.V. and Korablev, R.V. and Yurova, M.N. and Egormin, P.A. and Chernenko, N.A. and Gpopovich, I. and Tyndyk, M.L. and Verlov, N.A. and Artemenko, M.R. and Vasiliev, A.G. and Anisimov, V.N.},\\r\\ntitle={Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice},\\r\\njournal={Voprosy Onkologii},\\r\\nyear={2015},\\r\\nvolume={61},\\r\\nnumber={4},\\r\\npages={642-646},\\r\\nnote={cited By 1},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&partnerID=40&md5=25700032627eb71d9f9c0243ffa43e26},\\r\\naffiliation={State Pediatric Medical University, Russian Federation; N.N.Petrov Research Institute of Oncology, St.-Petersburg, Russian Federation},\\r\\nabstract={Age-dependent angiogenesis intensity changes have been studied in transgenic HER-2/neu (FBV/N) mice characteristic of breast tumors' high incidence with hyperexpression of HER- 2/neu. Concentration of vascular endothelial growth factor, insulin-dependent growth factor 1, nitrogen monoxide, tissue plasminogen activator and type 1 plasminogen activator inhibitor were assessed by means of immune-enzyme assay. The results testify to angiogenesis processes activation side by side with aging and growth of the tumors. Maximum manifestation of these disturbances (growth factors' blood concentrations increase and endotheliocytes' functional activity inhibition) has been revealed in 6-month-oId mice during neoplasma maximum intensive and aggressive growth period.},\\r\\nauthor_keywords={Age-dependent changes;  Angiogenesis;  Biomodeling;  Breast tumors;  Hemostasis;  HER- 2/neu;  IGF-1;  PAI-1;  TPA;  VEGF},\\r\\npublisher={Izdatel'stvo Meditsina},\\r\\nissn={05073758},\\r\\ncoden={VOONA},\\r\\npubmed_id={26571837},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Vopr. Onkol.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Trashkov, A.\",\"Panchenko, A.\",\"Korablev, R.\",\"Yurova, M.\",\"Egormin, P.\",\"Chernenko, N.\",\"Gpopovich, I.\",\"Tyndyk, M.\",\"Verlov, N.\",\"Artemenko, M.\",\"Vasiliev, A.\",\"Anisimov, V.\"],\"key\":\"Trashkov2015642\",\"id\":\"Trashkov2015642\",\"bibbaseid\":\"trashkov-panchenko-korablev-yurova-egormin-chernenko-gpopovich-tyndyk-etal-agedynamicsofangiogenesismarkersintransgenicher2neufbvnmammaryadenocarcinomapronemice-2015\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&partnerID=40&md5=25700032627eb71d9f9c0243ffa43e26\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kovalenko\"],\"firstnames\":[\"A.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tagirov\"],\"firstnames\":[\"N.S.\"],\"suffixes\":[]}],\"title\":\"Metabolic therapy of nephrolithiasis in two different rat models of kidney disease\",\"journal\":\"Eksperimental'naya i Klinicheskaya Farmakologiya\",\"year\":\"2015\",\"volume\":\"78\",\"number\":\"3\",\"pages\":\"17-21\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&partnerID=40&md5=84ca1147478becd454660d7e67dfab73\",\"affiliation\":\"Saint-Petersburg State Pediatric Medical University, Russian Federation; Toxicological Institute of Federal Medical Biological Agency, Russian Federation\",\"abstract\":\"108 albino male rats were used in two experimental rat models reproducing urolithiasis for the assessment of metabolic drug medicine Remaxol nephroprotecti-ve effect upon the development of this disease. \\\"Ethyleneglycol\\\" model consisted of adding 1 % ethylene glycol solution in drinking water for 37 days and \\\"fructose-induced\\\" one-of adding 10 % fructose solution in drinking water for the same period. Therapy included a 10-day course of daily i.v. injections of Remaxol (14 ml/kg). Both experimental models were successful in producing urolithiasis with considerable disturbances in the structure and functioning of kidneys up to revealing microconcrement formation. The \\\"ethyleneglycol\\\" model proved to cause maximum changes while the \\\"Fructose-induced\\\" model-only moderate ones. Metabolic correction of these changes was successful in nephroprotection effectively normalizing kidney functions and the total protein concentration, eliminating hyperglycemia and reducing creatinine and urea blood plasma concentration in both rat experimental models.\",\"author_keywords\":\"Experimental urolithiasis models; Metabolic medicines; Nephroprotection; Rats; Remaxol; Urolithiasis\",\"publisher\":\"Izdatel'stvo Meditsina\",\"issn\":\"08692092\",\"pubmed_id\":\"26036006\",\"language\":\"Russian\",\"abbrev_source_title\":\"Eksp. Klinicheskaya Farmakol.\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Trashkov201517,\\r\\nauthor={Trashkov, A.P. and Vasiliev, A.G. and Kovalenko, A.L. and Tagirov, N.S.},\\r\\ntitle={Metabolic therapy of nephrolithiasis in two different rat models of kidney disease},\\r\\njournal={Eksperimental'naya i Klinicheskaya Farmakologiya},\\r\\nyear={2015},\\r\\nvolume={78},\\r\\nnumber={3},\\r\\npages={17-21},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&partnerID=40&md5=84ca1147478becd454660d7e67dfab73},\\r\\naffiliation={Saint-Petersburg State Pediatric Medical University, Russian Federation; Toxicological Institute of Federal Medical Biological Agency, Russian Federation},\\r\\nabstract={108 albino male rats were used in two experimental rat models reproducing urolithiasis for the assessment of metabolic drug medicine Remaxol nephroprotecti-ve effect upon the development of this disease. \\\"Ethyleneglycol\\\" model consisted of adding 1 % ethylene glycol solution in drinking water for 37 days and \\\"fructose-induced\\\" one-of adding 10 % fructose solution in drinking water for the same period. Therapy included a 10-day course of daily i.v. injections of Remaxol (14 ml/kg). Both experimental models were successful in producing urolithiasis with considerable disturbances in the structure and functioning of kidneys up to revealing microconcrement formation. The \\\"ethyleneglycol\\\" model proved to cause maximum changes while the \\\"Fructose-induced\\\" model-only moderate ones. Metabolic correction of these changes was successful in nephroprotection effectively normalizing kidney functions and the total protein concentration, eliminating hyperglycemia and reducing creatinine and urea blood plasma concentration in both rat experimental models.},\\r\\nauthor_keywords={Experimental urolithiasis models;  Metabolic medicines;  Nephroprotection;  Rats;  Remaxol;  Urolithiasis},\\r\\npublisher={Izdatel'stvo Meditsina},\\r\\nissn={08692092},\\r\\npubmed_id={26036006},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Eksp. Klinicheskaya Farmakol.},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Trashkov, A.\",\"Vasiliev, A.\",\"Kovalenko, A.\",\"Tagirov, N.\"],\"key\":\"Trashkov201517\",\"id\":\"Trashkov201517\",\"bibbaseid\":\"trashkov-vasiliev-kovalenko-tagirov-metabolictherapyofnephrolithiasisintwodifferentratmodelsofkidneydisease-2015\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&partnerID=40&md5=84ca1147478becd454660d7e67dfab73\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Anisimov\"],\"firstnames\":[\"V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Popovich\"],\"firstnames\":[\"I.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Zabezhinski\"],\"firstnames\":[\"M.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Egormin\"],\"firstnames\":[\"P.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yurova\"],\"firstnames\":[\"M.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Semenchenko\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tyndyk\"],\"firstnames\":[\"M.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Panchenko\"],\"firstnames\":[\"A.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vasiliev\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Khaitsev\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]}],\"title\":\"Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973308\",\"journal\":\"Cell Cycle\",\"year\":\"2015\",\"volume\":\"14\",\"number\":\"1\",\"pages\":\"46-55\",\"doi\":\"10.4161/15384101.2014.973308\",\"note\":\"cited By 21\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&doi=10.4161%2f15384101.2014.973308&partnerID=40&md5=49a3af703f203dd6654be7b4c2fc0bb3\",\"affiliation\":\"N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation; St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation\",\"abstract\":\"The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of energy and metabolic homeostasis. We hypothesized that neonatal treatment with antidiabetic drug biguanide metformin would positively modify regulation of growth hormone - IGF-1 -insulin signaling pathway slowing down aging and improving cancer preventive patterns in rodents. To test this hypothesis male and female 129/Sv mice were s.c. injected with metformin (100 mg/kg) at the 3rd, 5th and 7th days after birth. Metformin-treated males consumed less food and water and their body weight was decreased as compared with control mice practically over their entire lifespan. There were no significant differences in age-related dynamics of food and water consumption in females and they were heavier than controls. The fraction of mice with regular estrous cycles decreased with age and demonstrated a tendency to decrease in the females neonatally treated with metformin. Neonatal exposure to metformin practically failed to change the extent of hormonal and metabolic parameters in blood serum of male and female mice. In males, neonatal metformin treatment significantly increased the mean life span (C20%, P < 0.05) and slightly increased the maximum life span (C3.5%). In females, the mean life span and median in metformin-treated groups were slightly decreased (-9.1% and -13.8% respectively, P > 0.05) in comparison to controls, whereas mean life span of last 10% survivors and maximum life span were the same as in controls. Almost half (45%) of control male mice and 71.8% male mice neonatally exposed to metformin survived up to 800 d of age, the same age was achieved by 54.3% of mice in control female group and 30% of metformin-treated females (P < 0.03). Thus, neonatal metformin exposure slows down aging and prolongs lifespan in male but not in female mice. © 2015 Taylor & Francis Group, LLC.\",\"author_keywords\":\"Biomarkers of aging; Carcinogenesis; Gender; Life extension; Metformin; Mice; Neonatal\",\"funding_details\":\"Ministry of Education and Science of the Russian Federation11–04–003472\",\"bibtex\":\"@ARTICLE{Anisimov201546,\\r\\nauthor={Anisimov, V. and Popovich, I.G. and Zabezhinski, M.A. and Egormin, P.A. and Yurova, M.N. and Semenchenko, A.V. and Tyndyk, M.L. and Panchenko, A.V. and Trashkov, A.P. and Vasiliev, A.G. and Khaitsev, N.V.},\\r\\ntitle={Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973308},\\r\\njournal={Cell Cycle},\\r\\nyear={2015},\\r\\nvolume={14},\\r\\nnumber={1},\\r\\npages={46-55},\\r\\ndoi={10.4161/15384101.2014.973308},\\r\\nnote={cited By 21},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&doi=10.4161%2f15384101.2014.973308&partnerID=40&md5=49a3af703f203dd6654be7b4c2fc0bb3},\\r\\naffiliation={N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation; St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation},\\r\\nabstract={The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of energy and metabolic homeostasis. We hypothesized that neonatal treatment with antidiabetic drug biguanide metformin would positively modify regulation of growth hormone - IGF-1 -insulin signaling pathway slowing down aging and improving cancer preventive patterns in rodents. To test this hypothesis male and female 129/Sv mice were s.c. injected with metformin (100 mg/kg) at the 3rd, 5th and 7th days after birth. Metformin-treated males consumed less food and water and their body weight was decreased as compared with control mice practically over their entire lifespan. There were no significant differences in age-related dynamics of food and water consumption in females and they were heavier than controls. The fraction of mice with regular estrous cycles decreased with age and demonstrated a tendency to decrease in the females neonatally treated with metformin. Neonatal exposure to metformin practically failed to change the extent of hormonal and metabolic parameters in blood serum of male and female mice. In males, neonatal metformin treatment significantly increased the mean life span (C20%, P < 0.05) and slightly increased the maximum life span (C3.5%). In females, the mean life span and median in metformin-treated groups were slightly decreased (-9.1% and -13.8% respectively, P > 0.05) in comparison to controls, whereas mean life span of last 10% survivors and maximum life span were the same as in controls. Almost half (45%) of control male mice and 71.8% male mice neonatally exposed to metformin survived up to 800 d of age, the same age was achieved by 54.3% of mice in control female group and 30% of metformin-treated females (P < 0.03). Thus, neonatal metformin exposure slows down aging and prolongs lifespan in male but not in female mice. © 2015 Taylor & Francis Group, LLC.},\\r\\nauthor_keywords={Biomarkers of aging;  Carcinogenesis;  Gender;  Life extension;  Metformin;  Mice;  Neonatal},\\r\\nfunding_details={Ministry of Education and Science of the Russian Federation11–04–003472},\\r\\n}\",\"author_short\":[\"Anisimov, V.\",\"Popovich, I.\",\"Zabezhinski, M.\",\"Egormin, P.\",\"Yurova, M.\",\"Semenchenko, A.\",\"Tyndyk, M.\",\"Panchenko, A.\",\"Trashkov, A.\",\"Vasiliev, A.\",\"Khaitsev, N.\"],\"key\":\"Anisimov201546\",\"id\":\"Anisimov201546\",\"bibbaseid\":\"anisimov-popovich-zabezhinski-egormin-yurova-semenchenko-tyndyk-panchenko-etal-sexdifferencesinaginglifespanandspontaneoustumorigenesisin129svmiceneonatallyexposedtometforminhttpwwwtandfonlinecomdoipdf104161153841012014973308-2015\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&doi=10.4161%2f15384101.2014.973308&partnerID=40&md5=49a3af703f203dd6654be7b4c2fc0bb3\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]}],\"title\":\"[Pathogenic variants of brain injuries and pharmalogic cerebroprotection performed on the model of brain condition during cardiovascular bypass surgery]\",\"journal\":\"Voenno-medit͡sinskiĭ zhurnal\",\"year\":\"2014\",\"volume\":\"335\",\"number\":\"10\",\"pages\":\"34-45\",\"note\":\"cited By 1\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&partnerID=40&md5=4d3932101742b08acb0601cf554911b0\",\"abstract\":\"Developed and approved a pathogenic grounded experimental model of brain condition during cardiovascular bypass surgery. Undertaken in Wistar rats research allowed to evaluate in detail effectiveness and safety of protracted cerebroprotective treatment. Advantages of this model are researches in laboratory animals with the aim to research condition of nerve tissue, not intensive procedures and consequently high reproducibility and possibility of complex evaluation of changes at every stage of research. Results of neurons, neuroglia and activation of neurotrophic mechanisms prove that simulation of brain condition during cardiovascular bypass surgery is accompanied with acute and delayed brain injuries. Use of Cytoflavin under pharmalogic cerebroprotection had prolonged multimodal and neuroprotactive effect, leading to improvement of neurotrophic protection from the first days.\",\"issn\":\"00269050\",\"pubmed_id\":\"25532310\",\"language\":\"Russian\",\"abbrev_source_title\":\"Voen Med Zh\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Tsygan201434,\\r\\nauthor={Tsygan, N.V. and Trashkov, A.P.},\\r\\ntitle={[Pathogenic variants of brain injuries and pharmalogic cerebroprotection performed on the model of brain condition during cardiovascular bypass surgery]},\\r\\njournal={Voenno-medit͡sinskiĭ zhurnal},\\r\\nyear={2014},\\r\\nvolume={335},\\r\\nnumber={10},\\r\\npages={34-45},\\r\\nnote={cited By 1},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&partnerID=40&md5=4d3932101742b08acb0601cf554911b0},\\r\\nabstract={Developed and approved a pathogenic grounded experimental model of brain condition during cardiovascular bypass surgery. Undertaken in Wistar rats research allowed to evaluate in detail effectiveness and safety of protracted cerebroprotective treatment. Advantages of this model are researches in laboratory animals with the aim to research condition of nerve tissue, not intensive procedures and consequently high reproducibility and possibility of complex evaluation of changes at every stage of research. Results of neurons, neuroglia and activation of neurotrophic mechanisms prove that simulation of brain condition during cardiovascular bypass surgery is accompanied with acute and delayed brain injuries. Use of Cytoflavin under pharmalogic cerebroprotection had prolonged multimodal and neuroprotactive effect, leading to improvement of neurotrophic protection from the first days.},\\r\\nissn={00269050},\\r\\npubmed_id={25532310},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Voen Med Zh},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Tsygan, N.\",\"Trashkov, A.\"],\"key\":\"Tsygan201434\",\"id\":\"Tsygan201434\",\"bibbaseid\":\"tsygan-trashkov-pathogenicvariantsofbraininjuriesandpharmalogiccerebroprotectionperformedonthemodelofbrainconditionduringcardiovascularbypasssurgery-2014\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&partnerID=40&md5=4d3932101742b08acb0601cf554911b0\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trashkov\"],\"firstnames\":[\"A.P.\"],\"suffixes\":[]}],\"title\":\"[Brain functional state and cytoprotective potential in model of acute cerebral hypoxia (experimental research)].\",\"journal\":\"Patologicheskaia fiziologiia i èksperimental'naia terapiia\",\"year\":\"2013\",\"number\":\"4\",\"pages\":\"10-16\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&partnerID=40&md5=29ed65140755fb5ce34683dfae316e97\",\"abstract\":\"The functional state of the brain and the potential of pharmacologic cytoprotection after an acute cerebral hypoxia were studied. The experiment involved 186 adult male rats. The rats in experimental groups underwent acute thromboembolism of the right carotid artery. The functional state of the brain and the efficacy and safety of the Cytoflavin complex cytoprotective drug treatment had been analyzed over the 10 days following the thromboembolism. A neurological examination was accomplished daily, the serum levels of NSE, GFAP, S100beta and brain cytolysate levels of NSE were measured on the 1st, 3rd, 10th day. The NSE brain cytolysate level went up on the 1st day and the NSE serum level was up on the 3rd day following the thromboembolism, which may have indicated an acute delayed alteration of neurons and an increase of the blood-brain barrier permeability on the 3rd day after the thromboemboIism. Neuroglial biomarkers went up on the 1st (GFAP), 3rd and 10th (S100beta) day, which indicated an acute delayed alteration and/or activation of glial cells. Therefore, the applied experimental model promotes acute delayed alteration of neurons and neuroglia with a possible activation of the latter. The Cytoflavin proved to have a cytoprotective effect on neurons and to diminish the alteration and/or activation of glial cells over the observed period after the acute thromboembolism of the carotid artery.\",\"correspondence_address1\":\"Tsygan, N.V.\",\"issn\":\"00312991\",\"pubmed_id\":\"24640767\",\"language\":\"Russian\",\"abbrev_source_title\":\"Patol Fiziol Eksp Ter\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Tsygan201310,\\r\\nauthor={Tsygan, N.V. and Trashkov, A.P.},\\r\\ntitle={[Brain functional state and cytoprotective potential in model of acute cerebral hypoxia (experimental research)].},\\r\\njournal={Patologicheskaia fiziologiia i èksperimental'naia terapiia},\\r\\nyear={2013},\\r\\nnumber={4},\\r\\npages={10-16},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&partnerID=40&md5=29ed65140755fb5ce34683dfae316e97},\\r\\nabstract={The functional state of the brain and the potential of pharmacologic cytoprotection after an acute cerebral hypoxia were studied. The experiment involved 186 adult male rats. The rats in experimental groups underwent acute thromboembolism of the right carotid artery. The functional state of the brain and the efficacy and safety of the Cytoflavin complex cytoprotective drug treatment had been analyzed over the 10 days following the thromboembolism. A neurological examination was accomplished daily, the serum levels of NSE, GFAP, S100beta and brain cytolysate levels of NSE were measured on the 1st, 3rd, 10th day. The NSE brain cytolysate level went up on the 1st day and the NSE serum level was up on the 3rd day following the thromboembolism, which may have indicated an acute delayed alteration of neurons and an increase of the blood-brain barrier permeability on the 3rd day after the thromboemboIism. Neuroglial biomarkers went up on the 1st (GFAP), 3rd and 10th (S100beta) day, which indicated an acute delayed alteration and/or activation of glial cells. Therefore, the applied experimental model promotes acute delayed alteration of neurons and neuroglia with a possible activation of the latter. The Cytoflavin proved to have a cytoprotective effect on neurons and to diminish the alteration and/or activation of glial cells over the observed period after the acute thromboembolism of the carotid artery.},\\r\\ncorrespondence_address1={Tsygan, N.V.},\\r\\nissn={00312991},\\r\\npubmed_id={24640767},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Patol Fiziol Eksp Ter},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Tsygan, N.\",\"Trashkov, A.\"],\"key\":\"Tsygan201310\",\"id\":\"Tsygan201310\",\"bibbaseid\":\"tsygan-trashkov-brainfunctionalstateandcytoprotectivepotentialinmodelofacutecerebralhypoxiaexperimentalresearch-2013\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&partnerID=40&md5=29ed65140755fb5ce34683dfae316e97\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Odinak\"],\"firstnames\":[\"M.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shamreǐ\"],\"firstnames\":[\"V.K.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chudinovskikh\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Goncharenko\"],\"firstnames\":[\"A.I.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]}],\"title\":\"[Stages of formation and development of the national military neurology and psychiatry].\",\"journal\":\"Voenno-meditcombining double inverted brevesinskiǐ zhurnal\",\"year\":\"2013\",\"volume\":\"334\",\"number\":\"12\",\"pages\":\"59-67\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&partnerID=40&md5=4c2de30409d0313ab295d6591e18b4c3\",\"abstract\":\"The article is devoted to the stages of formation and development of military neurology and psychiatry in Russia. Scholars of anxiety and mental disorders department of the Medical and Surgical Academy (Military Medical) made great contribution to development of scientific and organizational peculiarities of these medical disciplines and many other allied studies. Authors analyze the contribution of military psychiatrists and neurologists to the modern concept of mental care delivery in peace and wartime, research focus ares and prospects of its development.\",\"correspondence_address1\":\"Odinak, M.M.\",\"issn\":\"00269050\",\"pubmed_id\":\"24738283\",\"language\":\"Russian\",\"abbrev_source_title\":\"Voen Med Zh\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Odinak201359,\\r\\nauthor={Odinak, M.M. and Shamreǐ, V.K. and Chudinovskikh, A.G. and Goncharenko, A.I. and Tsygan, N.V.},\\r\\ntitle={[Stages of formation and development of the national military neurology and psychiatry].},\\r\\njournal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},\\r\\nyear={2013},\\r\\nvolume={334},\\r\\nnumber={12},\\r\\npages={59-67},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&partnerID=40&md5=4c2de30409d0313ab295d6591e18b4c3},\\r\\nabstract={The article is devoted to the stages of formation and development of military neurology and psychiatry in Russia. Scholars of anxiety and mental disorders department of the Medical and Surgical Academy (Military Medical) made great contribution to development of scientific and organizational peculiarities of these medical disciplines and many other allied studies. Authors analyze the contribution of military psychiatrists and neurologists to the modern concept of mental care delivery in peace and wartime, research focus ares and prospects of its development.},\\r\\ncorrespondence_address1={Odinak, M.M.},\\r\\nissn={00269050},\\r\\npubmed_id={24738283},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Voen Med Zh},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Odinak, M.\",\"Shamreǐ, V.\",\"Chudinovskikh, A.\",\"Goncharenko, A.\",\"Tsygan, N.\"],\"key\":\"Odinak201359\",\"id\":\"Odinak201359\",\"bibbaseid\":\"odinak-shamre-chudinovskikh-goncharenko-tsygan-stagesofformationanddevelopmentofthenationalmilitaryneurologyandpsychiatry-2013\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&partnerID=40&md5=4c2de30409d0313ab295d6591e18b4c3\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Odinak\"],\"firstnames\":[\"M.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yanishevskiǐ\"],\"firstnames\":[\"S.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Golokhvastov\"],\"firstnames\":[\"S.Y.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vozniuk\"],\"firstnames\":[\"I.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Trufanov\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]}],\"title\":\"The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke\",\"journal\":\"Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova\",\"year\":\"2013\",\"volume\":\"2013\",\"number\":\"12\",\"pages\":\"55-60\",\"note\":\"cited By 4\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&partnerID=40&md5=8188c3acced00cf4b96d213bf98cdab0\",\"affiliation\":\"Kirov Military Medical Academy, St. Petersburg, Russian Federation\",\"abstract\":\"The aim of the study was to determine the quantitative content and correlation between metabolites in the core ischemic zone, the ischemic penumbra and the intact tissue of the opposite hemisphere in the acute stage of ischemic stroke using MR-spectroscopy. We studied 72 patients, including 37 patients (the main group) treated with the antioxidant mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate) in addition to standard therapy and 35 patients who received standard therapy only. The severity of stroke was assessed using the NIHSS. The Barthel index and Rankin scale were used to evaluate functional outcome in the 30th day, hydrogen MR-spectroscopy was used twice: in the first 24 h from disease onset and in the 5th day. Mexidol used in dose 500 mg intravenously during 14 days reduced significantly the content of lactate (p=0.002) and inositol (p=0.005) in the cells compared to the control group that enhanced the restoration of the balance between aerobic and anaerobic mechanisms of oxidation and positively influenced on the rehabilitation of patients. Positive correlations between the content of lactate in the ischemic penumbra and NIHSS scores (r=0.5786; p=0.049) and the negative correlation between the content of lactate in the ischemic penumbra and the degree of functional restoration assessed by the Barthel index (r= -0.6305; p=0.028) were found. These findings support the evidence for the interaction between the disturbance of glucose metabolism in conditions of hypoxia and the degree of nervous tissue damage.\",\"author_keywords\":\"Antioxidants; Ischemic stroke; Magnetic resonance spectroscopy; Mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate)\",\"issn\":\"19977298\",\"pubmed_id\":\"24430036\",\"language\":\"English\",\"abbrev_source_title\":\"Zh. Nevrologii Psihiatrii im. S.S. Korsakova\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Odinak201355,\\r\\nauthor={Odinak, M.M. and Yanishevskiǐ, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Vozniuk, I.A. and Trufanov, A.G.},\\r\\ntitle={The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke},\\r\\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\\r\\nyear={2013},\\r\\nvolume={2013},\\r\\nnumber={12},\\r\\npages={55-60},\\r\\nnote={cited By 4},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&partnerID=40&md5=8188c3acced00cf4b96d213bf98cdab0},\\r\\naffiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation},\\r\\nabstract={The aim of the study was to determine the quantitative content and correlation between metabolites in the core ischemic zone, the ischemic penumbra and the intact tissue of the opposite hemisphere in the acute stage of ischemic stroke using MR-spectroscopy. We studied 72 patients, including 37 patients (the main group) treated with the antioxidant mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate) in addition to standard therapy and 35 patients who received standard therapy only. The severity of stroke was assessed using the NIHSS. The Barthel index and Rankin scale were used to evaluate functional outcome in the 30th day, hydrogen MR-spectroscopy was used twice: in the first 24 h from disease onset and in the 5th day. Mexidol used in dose 500 mg intravenously during 14 days reduced significantly the content of lactate (p=0.002) and inositol (p=0.005) in the cells compared to the control group that enhanced the restoration of the balance between aerobic and anaerobic mechanisms of oxidation and positively influenced on the rehabilitation of patients. Positive correlations between the content of lactate in the ischemic penumbra and NIHSS scores (r=0.5786; p=0.049) and the negative correlation between the content of lactate in the ischemic penumbra and the degree of functional restoration assessed by the Barthel index (r= -0.6305; p=0.028) were found. These findings support the evidence for the interaction between the disturbance of glucose metabolism in conditions of hypoxia and the degree of nervous tissue damage.},\\r\\nauthor_keywords={Antioxidants;  Ischemic stroke;  Magnetic resonance spectroscopy;  Mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate)},\\r\\nissn={19977298},\\r\\npubmed_id={24430036},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Odinak, M.\",\"Yanishevskiǐ, S.\",\"Tsygan, N.\",\"Golokhvastov, S.\",\"Vozniuk, I.\",\"Trufanov, A.\"],\"key\":\"Odinak201355\",\"id\":\"Odinak201355\",\"bibbaseid\":\"odinak-yanishevski-tsygan-golokhvastov-vozniuk-trufanov-theuseofsuccinatesforthecorrectionofmetabolicdisordersinthepenumbrainpatientswithstroke-2013\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&partnerID=40&md5=8188c3acced00cf4b96d213bf98cdab0\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Odinak\"],\"firstnames\":[\"M.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Neznanov\"],\"firstnames\":[\"N.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Chudinovskih\"],\"firstnames\":[\"A.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]}],\"title\":\"Vladimir Mikhailovitch Bekhterev - The founder of the clinical neuropsychiatry\",\"journal\":\"Vestnik Rossiiskoi Akademii Meditsinskikh Nauk\",\"year\":\"2012\",\"number\":\"8\",\"pages\":\"34-39\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&partnerID=40&md5=68d718e3c50f74bbb80b865028640312\",\"affiliation\":\"Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg, Russian Federation; Saint Petersburg Neuropsychiatry Research Institute n.a. V.M. Bekhterev, Russian Federation\",\"abstract\":\"The article presents main milestones in the career of Vladimir Mikhailovitch Bekhterev. The research in anatomy and physiology of the brain performed by V.M. Bekhterev gave original data of worldwide priority. V.M. Bekhterev significantly improved methodology of neurological examination and differential diagnosis in clinical neuropsychiatry. The scientific heritage of V.M. Bekhterev proves his outstanding role in establishment and development of the neuropsychiatry.\",\"author_keywords\":\"Clinical neuropsychiatry; History of neurology; History of psychiatry; V.M. Bekhterev\",\"correspondence_address1\":\"Odinak, M.M.; Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg, Russian Federation\",\"issn\":\"08696047\",\"pubmed_id\":\"23166987\",\"language\":\"Russian\",\"abbrev_source_title\":\"Vestn. Ross. Akad. Med. Nauk\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Odinak201234,\\r\\nauthor={Odinak, M.M. and Neznanov, N.G. and Chudinovskih, A.G. and Tsygan, N.V.},\\r\\ntitle={Vladimir Mikhailovitch Bekhterev - The founder of the clinical neuropsychiatry},\\r\\njournal={Vestnik Rossiiskoi Akademii Meditsinskikh Nauk},\\r\\nyear={2012},\\r\\nnumber={8},\\r\\npages={34-39},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&partnerID=40&md5=68d718e3c50f74bbb80b865028640312},\\r\\naffiliation={Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg, Russian Federation; Saint Petersburg Neuropsychiatry Research Institute n.a. V.M. Bekhterev, Russian Federation},\\r\\nabstract={The article presents main milestones in the career of Vladimir Mikhailovitch Bekhterev. The research in anatomy and physiology of the brain performed by V.M. Bekhterev gave original data of worldwide priority. V.M. Bekhterev significantly improved methodology of neurological examination and differential diagnosis in clinical neuropsychiatry. The scientific heritage of V.M. Bekhterev proves his outstanding role in establishment and development of the neuropsychiatry.},\\r\\nauthor_keywords={Clinical neuropsychiatry;  History of neurology;  History of psychiatry;  V.M. Bekhterev},\\r\\ncorrespondence_address1={Odinak, M.M.; Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg, Russian Federation},\\r\\nissn={08696047},\\r\\npubmed_id={23166987},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Vestn. Ross. Akad. Med. Nauk},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Odinak, M.\",\"Neznanov, N.\",\"Chudinovskih, A.\",\"Tsygan, N.\"],\"key\":\"Odinak201234\",\"id\":\"Odinak201234\",\"bibbaseid\":\"odinak-neznanov-chudinovskih-tsygan-vladimirmikhailovitchbekhterevthefounderoftheclinicalneuropsychiatry-2012\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&partnerID=40&md5=68d718e3c50f74bbb80b865028640312\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]}],\"title\":\"[The algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass].\",\"journal\":\"Voenno-meditcombining double inverted brevesinskiǐ zhurnal\",\"year\":\"2012\",\"volume\":\"333\",\"number\":\"6\",\"pages\":\"42-46\",\"note\":\"cited By 4\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&partnerID=40&md5=f5cb15bc2be8c2ca5685a1ed11bce224\",\"abstract\":\"The article presents the algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass, based on contemporary concept of intraoperative brain damage pathogenesis. The algorithm includes clinical, laboratory and instrumental diagnostic procedures in the perioperative period. The article shows the prospects of the use of the algorithm for optimizing neuroprotection and outcomes in cardiac surgery and acute stroke.\",\"correspondence_address1\":\"Tsygan, N.V.\",\"issn\":\"00269050\",\"pubmed_id\":\"22888701\",\"language\":\"Russian\",\"abbrev_source_title\":\"Voen Med Zh\",\"document_type\":\"Review\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Tsygan201242,\\r\\nauthor={Tsygan, N.V.},\\r\\ntitle={[The algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass].},\\r\\njournal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},\\r\\nyear={2012},\\r\\nvolume={333},\\r\\nnumber={6},\\r\\npages={42-46},\\r\\nnote={cited By 4},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&partnerID=40&md5=f5cb15bc2be8c2ca5685a1ed11bce224},\\r\\nabstract={The article presents the algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass, based on contemporary concept of intraoperative brain damage pathogenesis. The algorithm includes clinical, laboratory and instrumental diagnostic procedures in the perioperative period. The article shows the prospects of the use of the algorithm for optimizing neuroprotection and outcomes in cardiac surgery and acute stroke.},\\r\\ncorrespondence_address1={Tsygan, N.V.},\\r\\nissn={00269050},\\r\\npubmed_id={22888701},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Voen Med Zh},\\r\\ndocument_type={Review},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Tsygan, N.\"],\"key\":\"Tsygan201242\",\"id\":\"Tsygan201242\",\"bibbaseid\":\"tsygan-thealgorithmofthecomprehensiveassessmentofthebrainduringcardiacsurgerywithcardiopulmonarybypass-2012\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&partnerID=40&md5=f5cb15bc2be8c2ca5685a1ed11bce224\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Khubulava\"],\"firstnames\":[\"G.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ivchenko\"],\"firstnames\":[\"E.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Paǐvin\"],\"firstnames\":[\"A.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kravchuk\"],\"firstnames\":[\"V.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Iurchenko\"],\"firstnames\":[\"D.L.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Ivashchenko\"],\"firstnames\":[\"A.I.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Didenko\"],\"firstnames\":[\"M.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Luk'ianov\"],\"firstnames\":[\"N.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Peleshok\"],\"firstnames\":[\"A.S.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Liubimov\"],\"firstnames\":[\"A.I.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Naumov\"],\"firstnames\":[\"A.B.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Shorokhov\"],\"firstnames\":[\"K.H.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Sukharev\"],\"firstnames\":[\"A.E.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Kniazev\"],\"firstnames\":[\"E.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Porembskaia\"],\"firstnames\":[\"I.A.\"],\"suffixes\":[]}],\"title\":\"[Experience of left ventricular assist device \\\"Incor\\\" as \\\"bridge to recovery\\\" implantation in patients with end stage congestive heart failure].\",\"journal\":\"Voenno-meditcombining double inverted brevesinskiǐ zhurnal\",\"year\":\"2011\",\"volume\":\"332\",\"number\":\"11\",\"pages\":\"29-35\",\"note\":\"cited By 0\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&partnerID=40&md5=e62a131bbea78ac2407104486e0adcf2\",\"abstract\":\"Left ventricular assist device \\\"Incor\\\" (\\\"Berlinhear\\\", Germany) implantation experience in patient with ischemic cardiomiopathy and severe congestive heart failure is presented. Left ventricular assist device implantation was followed by coronary artery bypass grafting simultaneously. Total assist time was 211 days. Complications developed during assisting time are shown. After Left ventricular assist device explantation three chamber pacemaker was implanted as cardiac resynchronization therapy. Left ventricular end diastolic size decreased (from 78 to 70 mm), ejection fraction increased (from 19 to 35%) during assist time.\",\"correspondence_address1\":\"Khubulava, G.G.\",\"issn\":\"00269050\",\"pubmed_id\":\"22329169\",\"language\":\"Russian\",\"abbrev_source_title\":\"Voen Med Zh\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Khubulava201129,\\r\\nauthor={Khubulava, G.G. and Ivchenko, E.V. and Paǐvin, A.A. and Kravchuk, V.N. and Iurchenko, D.L. and Ivashchenko, A.I. and Didenko, M.V. and Luk'ianov, N.G. and Peleshok, A.S. and Tsygan, N.V. and Liubimov, A.I. and Naumov, A.B. and Shorokhov, K.H. and Sukharev, A.E. and Kniazev, E.A. and Porembskaia, I.A.},\\r\\ntitle={[Experience of left ventricular assist device \\\"Incor\\\" as \\\"bridge to recovery\\\" implantation in patients with end stage congestive heart failure].},\\r\\njournal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},\\r\\nyear={2011},\\r\\nvolume={332},\\r\\nnumber={11},\\r\\npages={29-35},\\r\\nnote={cited By 0},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&partnerID=40&md5=e62a131bbea78ac2407104486e0adcf2},\\r\\nabstract={Left ventricular assist device \\\"Incor\\\" (\\\"Berlinhear\\\", Germany) implantation experience in patient with ischemic cardiomiopathy and severe congestive heart failure is presented. Left ventricular assist device implantation was followed by coronary artery bypass grafting simultaneously. Total assist time was 211 days. Complications developed during assisting time are shown. After Left ventricular assist device explantation three chamber pacemaker was implanted as cardiac resynchronization therapy. Left ventricular end diastolic size decreased (from 78 to 70 mm), ejection fraction increased (from 19 to 35%) during assist time.},\\r\\ncorrespondence_address1={Khubulava, G.G.},\\r\\nissn={00269050},\\r\\npubmed_id={22329169},\\r\\nlanguage={Russian},\\r\\nabbrev_source_title={Voen Med Zh},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\\r\\n\",\"author_short\":[\"Khubulava, G.\",\"Ivchenko, E.\",\"Paǐvin, A.\",\"Kravchuk, V.\",\"Iurchenko, D.\",\"Ivashchenko, A.\",\"Didenko, M.\",\"Luk'ianov, N.\",\"Peleshok, A.\",\"Tsygan, N.\",\"Liubimov, A.\",\"Naumov, A.\",\"Shorokhov, K.\",\"Sukharev, A.\",\"Kniazev, E.\",\"Porembskaia, I.\"],\"key\":\"Khubulava201129\",\"id\":\"Khubulava201129\",\"bibbaseid\":\"khubulava-ivchenko-pavin-kravchuk-iurchenko-ivashchenko-didenko-lukianov-etal-experienceofleftventricularassistdeviceincorasbridgetorecoveryimplantationinpatientswithendstagecongestiveheartfailure-2011\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&partnerID=40&md5=e62a131bbea78ac2407104486e0adcf2\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"},{\"bibtype\":\"article\",\"type\":\"article\",\"author\":[{\"propositions\":[],\"lastnames\":[\"Odinak\"],\"firstnames\":[\"M.M.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Skvortsova\"],\"firstnames\":[\"V.I.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Vosniuk\"],\"firstnames\":[\"I.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Rumiantseva\"],\"firstnames\":[\"S.A.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Stakhovskaya\"],\"firstnames\":[\"L.V.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Klocheva\"],\"firstnames\":[\"E.G.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Novikova\"],\"firstnames\":[\"L.B.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Yanishevsky\"],\"firstnames\":[\"S.N.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Golokhvastov\"],\"firstnames\":[\"S.Y.\"],\"suffixes\":[]},{\"propositions\":[],\"lastnames\":[\"Tsygan\"],\"firstnames\":[\"N.V.\"],\"suffixes\":[]}],\"title\":\"Efficacy of cytoflavin in patients in the acute ischemic stroke\",\"journal\":\"Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova\",\"year\":\"2010\",\"volume\":\"110\",\"number\":\"12\",\"pages\":\"29-36\",\"note\":\"cited By 3\",\"url\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&partnerID=40&md5=3feeb5bc96137ec07e6c36691bccf7b4\",\"abstract\":\"We present the results of a multicenter study on efficacy of cytoflavin in the treatment of patients with acute ischemic stroke. Seventy patients (41 of the main group and 29 of the control group) were enrolled in the study. All patients received basic therapy aimed at improving systemic hemodynamics, rheological blood properties and at the prevention of stroke complications. Patients of the main group were treated with cytoflavin as follows: days 1-10 - 20 ml (in 400 ml of the 0,9% NaCl solution) twice a day intravenously in drops; days 11-35 - 850 mg twice a day. We assessed the dynamics of restoration of lost functions (NIHSS, the Rankin scale, the Barthel index) and volumes of ischemic lesion (MRI T1-, T2-, diffusion-weighted images). Results of the study on patients of the control group were supplemented with literature data about 306 patients studied using clinical scales and 40 patients studied with MRI. We revealed a trend towards an effect of cytoflavin on the preservation of brain matter in the acute phase of stroke. Cytoflavin reduced the neurological deficit and improved activities of daily living in patients that may be explained by the less brain damage.\",\"author_keywords\":\"Brain infarction volume; Cytoflavin, antioxidant; Ischemic stroke; Magnetic resonance tomography\",\"correspondence_address1\":\"Stakhovskaya, L. V.email: nabi@orc.ru\",\"issn\":\"19977298\",\"pubmed_id\":\"21311484\",\"language\":\"English\",\"abbrev_source_title\":\"Zh. Nevrologii Psihiatrii im. S.S. Korsakova\",\"document_type\":\"Article\",\"source\":\"Scopus\",\"bibtex\":\"@ARTICLE{Odinak201029,\\r\\nauthor={Odinak, M.M. and Skvortsova, V.I. and Vosniuk, I.A. and Rumiantseva, S.A. and Stakhovskaya, L.V. and Klocheva, E.G. and Novikova, L.B. and Yanishevsky, S.N. and Golokhvastov, S.Y. and Tsygan, N.V.},\\r\\ntitle={Efficacy of cytoflavin in patients in the acute ischemic stroke},\\r\\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\\r\\nyear={2010},\\r\\nvolume={110},\\r\\nnumber={12},\\r\\npages={29-36},\\r\\nnote={cited By 3},\\r\\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&partnerID=40&md5=3feeb5bc96137ec07e6c36691bccf7b4},\\r\\nabstract={We present the results of a multicenter study on efficacy of cytoflavin in the treatment of patients with acute ischemic stroke. Seventy patients (41 of the main group and 29 of the control group) were enrolled in the study. All patients received basic therapy aimed at improving systemic hemodynamics, rheological blood properties and at the prevention of stroke complications. Patients of the main group were treated with cytoflavin as follows: days 1-10 - 20 ml (in 400 ml of the 0,9% NaCl solution) twice a day intravenously in drops; days 11-35 - 850 mg twice a day. We assessed the dynamics of restoration of lost functions (NIHSS, the Rankin scale, the Barthel index) and volumes of ischemic lesion (MRI T1-, T2-, diffusion-weighted images). Results of the study on patients of the control group were supplemented with literature data about 306 patients studied using clinical scales and 40 patients studied with MRI. We revealed a trend towards an effect of cytoflavin on the preservation of brain matter in the acute phase of stroke. Cytoflavin reduced the neurological deficit and improved activities of daily living in patients that may be explained by the less brain damage.},\\r\\nauthor_keywords={Brain infarction volume;  Cytoflavin, antioxidant;  Ischemic stroke;  Magnetic resonance tomography},\\r\\ncorrespondence_address1={Stakhovskaya, L. V.email: nabi@orc.ru},\\r\\nissn={19977298},\\r\\npubmed_id={21311484},\\r\\nlanguage={English},\\r\\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\\r\\ndocument_type={Article},\\r\\nsource={Scopus},\\r\\n}\\r\\n\",\"author_short\":[\"Odinak, M.\",\"Skvortsova, V.\",\"Vosniuk, I.\",\"Rumiantseva, S.\",\"Stakhovskaya, L.\",\"Klocheva, E.\",\"Novikova, L.\",\"Yanishevsky, S.\",\"Golokhvastov, S.\",\"Tsygan, N.\"],\"key\":\"Odinak201029\",\"id\":\"Odinak201029\",\"bibbaseid\":\"odinak-skvortsova-vosniuk-rumiantseva-stakhovskaya-klocheva-novikova-yanishevsky-etal-efficacyofcytoflavininpatientsintheacuteischemicstroke-2010\",\"role\":\"author\",\"urls\":{\"Paper\":\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&partnerID=40&md5=3feeb5bc96137ec07e6c36691bccf7b4\"},\"metadata\":{\"authorlinks\":{}},\"html\":\"\"}],\n      metadata: {\"authorlinks\":{}},\n      ownerID: undefined\n    };\n  </script>\n\n  <script type=\"text/javascript\">\n  var site$;\n  if (typeof $ != 'undefined') {\n    console.log('existing jquery: storing and then restoring');\n    site$ = $;\n    $ = null;\n  }\n  </script>\n\n  <script src=\"https://ajax.googleapis.com/ajax/libs/jquery/2.2.4/jquery.min.js\">\n  </script>\n  <script type=\"text/javascript\">\n  if (site$) {\n    console.log('existing jquery: avoiding conflict and restoring');\n    bb$ = $.noConflict(true);\n    $ = site$;\n  } else {\n    bb$ = $;\n  }\n  </script>\n\n  <script src=\"//bibbase.org/js/bibbase.min.js\"\n          type=\"text/javascript\">\n  </script>\n\n  <script type=\"text/javascript\"\n          src=\"https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.1/MathJax.js?config=TeX-AMS-MML_HTMLorMML\">\n  </script>\n  <script type=\"text/x-mathjax-config\">\n    MathJax.Hub.Config({tex2jax: {inlineMath: [['$','$'], ['\\\\(','\\\\)']]},\n                        skipTags: [\"body\"],\n                        processClass: \"bibbase_paper\"});\n  </script>\n\n  <style>\n  @media print {\n    .dontprint {\n        display: none !important;\n    }\n\n  .bibbase_group {\n    background-color: #E0E0E0;\n    font-style: italic;\n    font-size: larger;\n    text-shadow: 0px 0px 3px #FFFFFF;\n    border-radius: 4px 4px 4px 4px;\n    -moz-border-radius: 4px 4px 4px 4px;\n    -webkit-border-radius: 4px;\n    padding: 5px 40px 5px;\n    margin-top: 10px;\n    margin-bottom: 5px;\n    cursor: pointer;\n  }\n\n  .bibbase_paper {\n    margin-bottom: 5px;\n  }\n\n  }\n  </style>\n\n  \n  <div style=\"float: right; margin-right: 10px; margin-top: 10px; text-align: right; font-size: 12px\">\n    generated by\n    <a href=\"//bibbase.org\"\n       onclick=\"trackOutboundLink('bibbase', 'logo clicked', window.location.href, '//bibbase.org'); return false;\">\n      <img src=\"//bibbase.org/img/logo.svg\"\n           style=\"vertical-align: middle; margin-left: 3px; height: 16px;\"/\n           alt=\"bibbase.org\"\n           title=\"BibBase – The easiest way to maintain your publications page.\"\n        ></a>\n    \n  </div>\n  \n\n  <div id=\"bibbase_header\" class=\"dontprint\" style=\"\">\n\n    <ul class=\"nav nav-pills\" style=\"margin: 0px;\">\n\n      <li class=\"dropdown\" id=\"groupby_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\">\n          Group by\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li class=\"groupby year\"><a onclick=\"groupby('year')\">\n            Year</a>\n        </li>\n        <li class=\"groupby author\"><a onclick=\"groupby('author_short')\">\n            Author</a>\n        </li>\n        <li class=\"groupby type\"><a onclick=\"groupby('type')\">\n            Type</a>\n        </li>\n        <li class=\"groupby keyword\"><a onclick=\"groupby('keyword')\">\n            Keyword</a>\n        </li>\n        <li class=\"groupby downloads\"><a onclick=\"groupby('downloads')\">\n            Downloads</a>\n        </li>\n      </ul>\n      </li>\n\n\n      <li class=\"dropdown\" id=\"menu_dropdown\">\n      <a class=\"dropdown-toggle\"\n         data-toggle=\"dropdown\"\n         href=\"#\" alt=\"controls\">\n          <i class=\"fa fa-reorder\" alt=\"controls\"></i>\n          <b class=\"caret\"></b>\n      </a>\n      <ul class=\"dropdown-menu\">\n        <li>\n          <a onclick=\"toggleAll()\">\n            <i class=\"fa fa-chevron-down fa-fw\"></i> Expand/Collapse All\n          </a>\n        </li>\n        <li>\n          <a download=\"cdki_2019_10.txt\" href=\"data:text/bibtex;base64,

@ARTICLE{Litvinenko201918,
author={Litvinenko, I.V. and Odinak, M.M. and Tsygan, N.V. and Andreev, R.V. and Peleshok, A.S. and Kurasov, E.S. and Yakovleva, V.A. and Ryabtsev, A.V.},
title={Characteristics of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve},
journal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},
year={2019},
volume={119},
number={2},
pages={18-22},
doi={10.17116/jnevro201911902118},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&doi=10.17116%2fjnevro201911902118&partnerID=40&md5=361a4ae7b1be819ac3bf90149cfd0de6},
affiliation={Kirov Military Medical Academy, St.-Petersburg, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Leningrad region, Russian Federation; Dzhanelidze St.-Petersburg Research Institute of Emergency Medicine, St.-Petersburg, Russian Federation},
abstract={Objective. To study the prevalence and structure of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve in patients who underwent surgery for the acquired heart valve disease. Material and methods. The study included 115 patients (70 men and 45 women; 64 [56; 72] years old), who underwent elective replacement or repair surgery for the acquired heart valve disease. Results and conclusion. The postoperative cerebral dysfunction was diagnosed in 40.9% patients, including replacement in the aortic position (45.5%), in the mitral position (55%), in several positions (20%). Replacement surgery was accompanied by three clinical types of postoperative cerebral dysfunction and repair surgery — by deferred cognitive impairment only. Postoperative cerebral dysfunction after the replacement in the mitral position was more common (odds ratio 4.47, 95% confidence interval 1.21—18.35, p=0.041), including its acute clinical types — perioperative stroke and symptomatic delirium of the early postoperative period (p=0.029), compared to that after the repair heart valve surgery. After the replacement in the aortic position, acute clinical types of postoperative cerebral dysfunction were more common (p=0.036). After the replacement with biological prosthesis, symptomatic delirium of the early postoperative period was more common (p=0.047). The occurrence of the deferred cognitive impairment didn’t depend on the type and position of the implanted prosthetic heart valve. © 2019, Media Sphera Publishing Group. All right reserved.},
author_keywords={Acquired heart valve disease;  Deferred cognitive impairment;  Heart valve repair surgery;  Heart valve replacement surgery;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},
correspondence_address1={Tsygan, N.V.; Kirov Military Medical AcademyRussian Federation; email: 77tn77@gmail.com},
publisher={Media Sphera Publishing Group},
issn={19977298},
pubmed_id={30874521},
language={Russian},
abbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},
document_type={Article},
source={Scopus},
}









@ARTICLE{Vasiliev201871,
author={Vasiliev, A.G. and Churilov, L.P. and Trashkov, A.P. and Utekhin, V.I.},
title={Evolution of the immune system and regulatory effects of antibodies},
journal={Tsitologiya},
year={2018},
volume={60},
number={2},
pages={71-80},
doi={10.31116/tsitol.2018.02.01},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&doi=10.31116%2ftsitol.2018.02.01&partnerID=40&md5=4f72752ca24dd84fcf15a3c741525d12},
affiliation={St. Petersburg State Pediatric Medical University, St. Petersburg, 194353, Russian Federation; St. Petersburg State University, St. Petersburg, 199106, Russian Federation; Petersburg Nuclear Physics Institute named by, B. P. Konstantinov of National Research Centre «Kurchatov Institute», Gatchina, 188300, Russian Federation},
abstract={The immune system is usually regarded as a tool for defense against pathogens. The review however focuses at non-traditional aspects of immune system activity that are seldom discussed. Immunoglobulins are products of genes super-family which is a part of cell adhesion molecules genes associated with multicellularity and thus in addition to regulation of immune response antibodies may accomplish integrative regulatory effects outside immune system using the very same principles (complementarity, positive and negative feedback, etc.), that are characteristic of the nervous and endocrine systems. The review sums up general principles of the antibodies’ regulatory effects in physiologic and pathologic processes as well as mechanisms that help them penetrate intact cell membrane and travel further into the nucleus and the principles of their intracellular activity by means of repression (derepression) of key cellular structures. © 2018 Sankt Peterburg.All rights reserved.},
author_keywords={Antinuclear antibodies;  Derepression;  Immunoglobuline regulation;  Regulatory effects of antibodies;  Repression},
correspondence_address1={Vasiliev, A.G.; St. Petersburg State Pediatric Medical UniversityRussian Federation; email: avas7@mail.ru},
publisher={Sankt Peterburg},
issn={00413771},
coden={TSITA},
language={Russian},
abbrev_source_title={Tsitologiya},
document_type={Article},
source={Scopus},
}



@ARTICLE{Tsygan201852,
author={Tsygan, N.V. and Andreev, R.V. and Peleshok, A.S. and Kolomentsev, S.V. and Yakovleva, V.A. and Ryabtsev, A.V. and Gumennaya, M.A. and Litvinenko, I.V.},
title={Perioperative stroke in heart valve surgery: Pathogenesis, clinical findings, diagnosis, prevention, treatment},
journal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},
year={2018},
volume={118},
number={4},
pages={52-60},
doi={10.17116/jnevro20181184152-60},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&doi=10.17116%2fjnevro20181184152-60&partnerID=40&md5=131b0d4388095a7f8bbc47747a3505af},
affiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russian Federation; Dzhanelidze St. Petersburg Research Institute of Emergency Medicine, St. Petersburg, Russian Federation; Sechenov Institute of Evolutionary Biochemistry and Physiology of Russian Academy of Science, St. Petersburg, Russian Federation},
abstract={Objective. To study risk factors, characteristics of clinical symptoms and diagnosis, and possibilities of prevention of perioperative stroke and other clinical types of cerebral dysfunction in main types of heart valve surgery. Material and methods. The study included 83 patients, aged 63 (54; 70) years, undergoing heart valve surgery with cardiopulmonary bypass. Results. Postoperative cerebral dysfunction was diagnosed in 37.3% of cases, including perioperative stroke in 3.6% of cases. In cases of aortic stenosis, the frequency of perioperative stroke was 9.5%. The cardioembolic subtype of perioperative ischemic stroke in cardiac valve surgery was most likely. The risk factors of the symptomatic delirium of the early postoperative period are: age over 75 years, preoperative frontal dysfunction, duration of artificial respiratory care more than 20 hours after the surgery. Conclusion. The results suggest the efficacy of preventive use of cytoflavin for reducing the frequency and severity of perioperative stroke and symptomatic delirium of the early postoperative period in heart valve surgery with cardiopulmonary bypass. © 2018, Media Sphera Publishing Group. All Rights Reserved.},
author_keywords={Cardiopulmonary bypass;  Cytoflavin;  Delayed cognitive impairment;  Heart valve surgery;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},
publisher={Media Sphera Publishing Group},
issn={19977298},
pubmed_id={29863693},
language={Russian},
abbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},
document_type={Article},
source={Scopus},
}



@ARTICLE{Shtam201823,
author={Shtam, T.A. and Samsonov, R.A. and Volnitskiy, A.V. and Kamyshinsky, R.A. and Verlov, N.A. and Kniazeva, M.S. and Korobkina, E.A. and Orehov, A.S. and Vasiliev, A.L. and Konevega, A.L. and Malek, A.V.},
title={Isolation of extracellular micro-vesicles from cell culture medium: Comparative evaluation of methods},
journal={Biomeditsinskaya Khimiya},
year={2018},
volume={64},
number={1},
pages={23-30},
doi={10.18097/PBMC20186401023},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&doi=10.18097%2fPBMC20186401023&partnerID=40&md5=b472419d6f68dab8bffc8f53af96f345},
affiliation={Petersburg Nuclear Physics Institute of National Research Centre 'Kurchatov Institute', Saint-Petersburg, Gatchina, 188300, Russian Federation; 'Oncosystem' Ltd., Skolkovo, 143026, Russian Federation; N.N.Petrov National Medical Research Center of Oncology, Saint-Petersburg, 197758, Russian Federation; National Research Center 'Kurchatov Institute', Moscow, 123182, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, 195251, Russian Federation},
abstract={Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by "horizontal" exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional features of the EV is being commonly studies in in vitro condition. Several methods of EV isolation from cell culture medium are established, however selection of method might influence on obtained results. The choice of the optimal method depends usually from the amount of medium and the aims of the research while is still challenging issue. We performed a comparative analysis of four different methods of EV isolation from cell culture medium: differential ultracentrifugation, ultracentrifugation with a 30% sucrose/D2O "cushion", precipitation with plant proteins and immune-affinity capturing. EV isolated by different approaches were compared in terms of following parameters: size, concentration, morphology of EV, contamination by non-vesicular particles, content of exosomal tetraspanins on the EV surface, content of total proteins, RNA, and several glioma-associated miRNAs. Applied methods included nano-patricle tracking analysis (NTA), dynamic light scattering (DLS), cryo-electron microscopy, flow cytometry and RT-qPCR. On the base of obtained results, we developed practical recommendations that may help researchers to make a best choice of EV isolation method. © 2018 Russian Academy of Medical Sciences. All rights reserved.},
author_keywords={Exsosomes;  Extracellular vesicles;  Immunoprecipitation;  Lectines;  Methods of isolation;  Ultracentrifugation},
correspondence_address1={Shtam, T.A.; Petersburg Nuclear Physics Institute of National Research Centre 'Kurchatov Institute'Russian Federation; email: tatyana_shtam@mail.ru},
publisher={Russian Academy of Medical Sciences},
issn={23106905},
pubmed_id={29460831},
language={Russian},
abbrev_source_title={Biomeditsinskaya Khim.},
document_type={Article},
source={Scopus},
}



@CONFERENCE{Shtam2017,
author={Shtam, T. and Samsonov, R. and Kamyshinsky, R. and Pantina, R. and Verlov, N. and Vasiliev, A. and Konevega, A.L. and Malek, A.V.},
title={Exosomes: Some approaches to cancer diagnosis and therapy},
journal={AIP Conference Proceedings},
year={2017},
volume={1882},
doi={10.1063/1.5001645},
art_number={020066},
note={cited By 5; Conference of International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 ; Conference Date: 23 May 2017 Through 26 May 2017;  Conference Code:133914},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&doi=10.1063%2f1.5001645&partnerID=40&md5=d908b66243d4ade3a27c45bad492f886},
affiliation={Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov Institute, Gatchina, Russian Federation; Petrov Institute of Oncology, Saint-Petersburg, Russian Federation; Ltd. Oncosystem, Skolkovo, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, Russian Federation; National Research Center, Kurchatov Institute, Moscow, Russian Federation},
abstract={Exosomes are membrane-bound, intercellular communication shuttle vesicles that are defined by their endocytic origin and size range of 30-120 nm. Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive tool in identifying cancer biomarkers and exploiting exosomes for therapy. In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. Here, we present the possibility of carrying the exogenous p53 protein by exosomes in vitro. © 2017 Author(s).},
correspondence_address1={Shtam, T.; Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov InstituteRussian Federation; email: tatyana_shtam@mail.ru},
editor={Gutmanas E.Y., Naimark O.B., Sharkeev Y.P.},
sponsors={Institute of Continuous Media Mechanics of UrB RAS; Institute of Strength Physics and Materials Science of SB RAS; National Research Tomsk Polytechnic University; National Research Tomsk State University; Tomsk Research Institute of Oncology},
publisher={American Institute of Physics Inc.},
issn={0094243X},
isbn={9780735415621},
language={English},
abbrev_source_title={AIP Conf. Proc.},
document_type={Conference Paper},
source={Scopus},
}



@ARTICLE{Stupin2017,
author={Stupin, D.D. and Koniakhin, S.V. and Verlov, N.A. and Dubina, M.V.},
title={Adaptive Filtering to Enhance Noise Immunity of Impedance and Admittance Spectroscopy: Comparison with Fourier Transformation},
journal={Physical Review Applied},
year={2017},
volume={7},
number={5},
doi={10.1103/PhysRevApplied.7.054024},
art_number={054024},
note={cited By 8},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&doi=10.1103%2fPhysRevApplied.7.054024&partnerID=40&md5=58dc07671359acd5a9cf7852835d8eba},
affiliation={St. Petersburg Academic University, Khlopina 8/3, St. Petersburg, 194021, Russian Federation; Petersburg Nuclear Physics Institute NRC Kurchatov Institute, Gatchina, St. Petersburg, 188300, Russian Federation; Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya str. 29, St. Petersburg, 195251, Russian Federation},
abstract={The time-domain technique for impedance spectroscopy consists of computing the excitation voltage and current response Fourier images by fast or discrete Fourier transformation and calculating their relation. Here we propose an alternative method for excitation voltage and current response processing for deriving a system impedance spectrum based on a fast and flexible adaptive filtering method. We show the equivalence between the problem of adaptive filter learning and deriving the system impedance spectrum. To be specific, we express the impedance via the adaptive filter weight coefficients. The noise-canceling property of adaptive filtering is also justified. Using the RLC circuit as a model system, we experimentally show that adaptive filtering yields correct admittance spectra and elements ratings in the high-noise conditions when the Fourier-transform technique fails. Providing the additional sensitivity of impedance spectroscopy, adaptive filtering can be applied to otherwise impossible-to-interpret time-domain impedance data. The advantages of adaptive filtering are justified with practical living-cell impedance measurements. © 2017 American Physical Society.},
publisher={American Physical Society},
issn={23317019},
language={English},
abbrev_source_title={Phys. Rev. Appl.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Derkach2017130,
author={Derkach, K.V. and Bondareva, V.M. and Trashkov, A.P. and Chistyakova, O.V. and Verlov, N.A. and Shpakov, A.O.},
title={Metabolic and hormonal indices in rats with a prolonged model of the metabolic syndrome induced by a high-carbohydrate and high-fat diet},
journal={Advances in Gerontology},
year={2017},
volume={7},
number={2},
pages={130-136},
doi={10.1134/S2079057017020035},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&doi=10.1134%2fS2079057017020035&partnerID=40&md5=d87870b22f7bf0c1ea94f6adc3d657af},
affiliation={Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russian Federation},
abstract={To develop approaches for the prevention and treatment of the metabolic syndrome (MS), a pathological state widespread in the modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of the MS are required. One of these models is induced by the consumption of a combined high-carbohydrate and high-fat (HC/HF) diet. However, the character, temporal dynamics and severity of the metabolic abnormalities in MS induced by the HC/HF diet are still poorly understood. The aim of this work was to characterize the metabolic changes in Wistar rats with the MS induced by a 10- and 15-week HC/HF diet which included the consumption of a 30% sucrose solution (instead of drinking water) and food rich in saturated fats. The rats which received the HC/HF diet for 15 weeks had a number of features characteristic of the MS such as increased body mass and a specific content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system, hyperhomocysteinemia, a reduced level of nitric oxide and increased concentration of endothelin-1. In the rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of a 10-week duration of the HC/HF diet for the MS induction. Thus, the model of the MS induced by a 15-week HC/HF diet has the characteristic features which allow for extrapolation of the obtained data to similar pathologic changes in humans, and can be used in the study of the etiology and pathogenesis of the MS and in the search for effective ways of MS prevention and treatment. © 2017, Pleiades Publishing, Ltd.},
author_keywords={biomodelling;  dyslipidemia;  endothelial dysfunction;  glucose tolerance;  high-carbohydrate and high-fat diet;  insulin resistance;  metabolic syndrome},
correspondence_address1={Derkach, K.V.; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of SciencesRussian Federation; email: derkatch_k@list.ru},
publisher={Maik Nauka Publishing / Springer SBM},
issn={20790570},
language={English},
abbrev_source_title={Adv. Gerontol.},
document_type={Article},
source={Scopus},
}





@ARTICLE{Derkach201731,
author={Derkach, K.V. and Bondareva, V.M. and Trashkov, A.P. and Chistyakova, O.V. and Verlov, N.A. and Shpakov, A.O.},
title={Metabolic and hormonal indices in rats with prolonged model of metabolic syndrome induced by high-carbohydrate and high-fat diet},
journal={Advances in gerontology = Uspekhi gerontologii},
year={2017},
volume={30},
number={1},
pages={31-38},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&partnerID=40&md5=b0a1e874778d13e5a015e02345df4028},
affiliation={I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, Saint-Petersburg, 194223, Russian Federation; derkatch_k@list.ru},
abstract={To develop the approaches for the prevention and treatment of metabolic syndrome (MS), a pathological state widespread in modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of MS are required. One of these models is induced by the consumption of combined high-carbohydrate and high-fat (HC/HF) diet consisting of excess amount of easily digestible carbohydrates and saturated fats. At the same time, the character, temporal dynamics and severity of metabolic abnormalities in MS induced by HC/HF diet are still poorly understood. The aim of work was the characterization of metabolic changes in Wistar rats with MS induced by 10- and 15-week HC/HF diet that includes the consumption of 30% sucrose solution (instead of drinking water) and food rich in saturated fats. Rats that received HC/HF diet for 15 weeks had a number of features characteristic of MS, such as increased body weight and content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system (hyperhomocysteinemia, the reduced level of vasodilator nitric oxide, the increased concentration of vasoconstrictor endothelin 1). In rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of 10-week duration of HC/HF diet for MS induction. Thus, the model of MS induced by 15-week HC/HF diet has the characteristic features that allow for extrapolation of the obtained data to similar pathologic changes in human, and can be used to study the etiology and pathogenesis of MS and the search of effective ways of MS prevention and treatment.
Для разработки методов профилактики и лечения метаболического синдрома (МС), необходимы адекватные его модели на животных. Одна из таких моделей индуцируется потреблением комбинированного высокоуглеводного и высокожирового (ВУ/ВЖ) рациона. Однако характер, динамика во времени и степень тяжести метаболических нарушений при индукции МС с помощью ВУ/ВЖ диеты остаются мало изученными. Цель работы состояла в характеристике метаболических изменений в организме крыс линии Wistar с МС, вызванным 10- и 15-недельной ВУ/ВЖ диетой, которая включала потребление 30 % раствора сахарозы (вместо питьевой воды) и пищи, обогащенной насыщенными жирами. У крыс, получавших ВУ/ВЖ диету в течение 15 нед, отмечали признаки, характерные для МС, — повышение массы тела и удельного содержания абдоминального жира, гипергликемию, гиперинсулинемию, нарушенную толерантность к глюкозе, инсулиновую резистентность, дислипидемию, а также — маркеры нарушений функции сердечно-сосудистой системы — гипергомоцистеинемию, снижение уровня оксида азота и повышение концентрации эндотелина-1. У крыс, находящихся на диете в течение 10 нед, метаболические нарушения были выражены намного слабее, что указывает на недостаточность данной продолжительности ВУ/ВЖ диеты для индукции МС. Таким образом, модель МС, вызываемая 15-недельной ВУ/ВЖ диетой, имеет характерные признаки, позволяющие проводить экстраполяцию полученных данных на сходные патологические изменения у человека, и может быть использована для изучения этиологии и патогенеза МС и поиска эффективных путей его профилактики и лечения.},
author_keywords={biomodeling;  dyslipidemia;  endothelial dysfunction;  glucose tolerance;  high-carbohydrate and high-fat diet;  insulin resistance;  metabolic syndrome},
issn={15619125},
pubmed_id={28557387},
language={Russian},
abbrev_source_title={Adv Gerontol},
document_type={Article},
source={Scopus},
}



@ARTICLE{Yanishevsky201778,
author={Yanishevsky, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Andreev, R.V. and Litvinenko, I.V. and Karpova, O.S. and Yakovleva, V.A.},
title={Modern strategies of protection of hypoxic-ischemic brain damage},
journal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},
year={2017},
volume={117},
number={12},
pages={78-86},
doi={10.17116/jnevro201711712278-86},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&doi=10.17116%2fjnevro201711712278-86&partnerID=40&md5=76c5f916d4b4f14fdb4d0bd05109ba70},
affiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation},
abstract={Nowadays, there are two complementary approaches to treatment of patients with ischemic stroke: reperfusion and neuroprotection. The main purpose of neuroprotection is to intervene ischemic cascade at every stage of the pathological process and thus avoid the death of nerve cells and expand the therapeutic window for reperfusion therapy. The use of drugs with neurotrophic, antioxidant and neuroregenerative effects is pathogenically explained at all stages of post stroke rehabilitation. Ethylmethylhydroxypyridine succinate (mexidol) is a derivative of succinic acid with antihypoxic, membrane protective, nootropic, anticonvulsant and sedative action. The majority of researchers confirmed the positive effect of mexidol expressed as the marked regression of neurological deficit and wider opportunities for further early rehabilitation. The results of the randomized double blind multicenter placebo-controlled, parallel-group trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA) were published in 2017. The results of the study showed the best positive dynamics of neurological function recovery in case of timely treatment with mexidol with the following two month therapy. The safety of the long-term use of mexidol was confirmed. © 2017, Media Sphera Publishing Group. All rights reserved.},
author_keywords={Acute period;  Efficacy of treatment;  Neuroprotection;  Safety of therapy;  Stroke;  Succinate},
correspondence_address1={Yanishevsky, S.N.; Kirov Military Medical AcademyRussian Federation; email: stasya71@yandex.ru},
publisher={Media Sphera Publishing Group},
issn={19977298},
pubmed_id={29411750},
language={Russian},
abbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},
document_type={Article},
source={Scopus},
}



@ARTICLE{Tsygan201734,
author={Tsygan, N.V. and Odinak, M.M. and Khubulava, G.G. and Tsygan, V.N. and Peleshok, A.S. and Andreev, R.V. and Kurasov, E.S. and Litvinenko, I.V.},
title={Postoperative cerebral dysfunction},
journal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},
year={2017},
volume={117},
number={4},
pages={34-39},
doi={10.17116/jnevro20171174134-39},
note={cited By 3},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&doi=10.17116%2fjnevro20171174134-39&partnerID=40&md5=b6de900a49a34dcf567194a67b4eb6cb},
affiliation={Kirov Military Medical Academy, Saint Petersburg, Russian Federation},
abstract={Objective. To study the structure, risk factors and methods of prevention of postoperative brain dysfunction on the example of coronary artery bypass surgery with cardiopulmonary bypass. Material and methods. The study included 77 patients who undergone elective coronary artery bypass surgery at the beating heart (22 patients) or with cardiopulmonary bypass (55 patients, including 24 patients, who received cerebroprotective treatment with cytoflavin in the preoperative period). All patients underwent dynamic (pre- and postoperative) neurological, neuropsychological, instrumental examinations. Results. The postoperative cerebral dysfunction was diagnosed in 34 (44,2%) patients. The frequency of the clinical types of postoperative cerebral dysfunction significantly differed: perioperative stroke - 3 (3,9%) cases, symptomatic delirium of the early postoperative period - 11 (14,3%) cases, delayed cognitive impairment - 28 (36,4%) cases. The risk factors of postoperative cerebral dysfunction after the coronary artery bypass surgery with cardiopulmonary bypass were identified. Preventive preoperative use of the neuroprotective drug cytoflavin reduces the severity of delayed cognitive impairment after the coronary artery bypass surgery with cardiopulmonary bypass and has a good safety profile. Conclusion. An analysis of the literature data and the results of our own studies show that postoperative cerebral dysfunction is the nosological entity with various etiological factors, pathogenetic mechanisms and the characteristic clinical types, which has an effect on the outcome of surgical treatment. © 2017, Media Sphera, All rights reserved.},
author_keywords={Cytoflavin;  Deferred cognitive impairment;  Neuroprotection;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},
publisher={Media Sphera Publishing Group},
issn={19977298},
pubmed_id={28617376},
language={Russian},
abbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},
document_type={Article},
source={Scopus},
}



@ARTICLE{Valeev201652,
author={Valeev, V.V. and Trashkov and Kovaleko, A.L. and Petrov, A.U. and Vasiliev, A.G.},
title={Sodium-L-arginine succinate - a new vasodilating medicine for the treatment and prophylaxis of doxorubicin-induced cardiotoxicity},
journal={Patologicheskaia fiziologiia i eksperimental'naia terapiia},
year={2016},
volume={60},
number={4},
pages={52-57},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&partnerID=40&md5=16d4946de92f1d75751f52d54696233e},
abstract={The purpose: to ascertain possible cardioprotective effect of Sodium-L-arginine Succinate in case of myocardial lesions caused by Doxorubicin in rats. Methods. The effectiveness of the drug was assessed by morphometric and biochemical changes reflecting peroxidation intensity and structural and functional changes in myocardium. Results. Sodium-L-arginine Succinate used for the treatment and prophylaxis of antracyclic cardiomyopathy was demonstrated to decrease Doxorubicin effects lessening cardiomyocytal destruction and the left ventricular dysfunction with myocardial hypertrophy.},
issn={00312991},
pubmed_id={29244923},
language={English},
abbrev_source_title={Patol Fiziol Eksp Ter},
document_type={Article},
source={Scopus},
}



@ARTICLE{Panchenko2016317,
author={Panchenko, A.V. and Popovich, I.G. and Trashkov, A.P. and Egormin, P.A. and Yurova, M.N. and Tyndyk, M.L. and Gubareva, E.A. and Artyukin, I.N. and Vasiliev, A.G. and Khaitsev, N.V. and Zabezhinski, M.A. and Anisimov, V.N.},
title={Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice},
journal={Biogerontology},
year={2016},
volume={17},
number={2},
pages={317-324},
doi={10.1007/s10522-015-9611-y},
note={cited By 3},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&doi=10.1007%2fs10522-015-9611-y&partnerID=40&md5=fc4716a4bfbb936f6387a9fcb505bf7e},
affiliation={Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, 197758, Russian Federation; St.Petersburg State Pediatric Medical University, 2, Litovskaya str., St. Petersburg, 194100, Russian Federation},
abstract={FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %—800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis. © 2015, Springer Science+Business Media Dordrecht.},
author_keywords={Biomarkers of aging;  FVB/N mice;  HER-2/neu;  Life span;  Spontaneous carcinogenesis},
correspondence_address1={Anisimov, V.N.; Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, Russian Federation; email: aging@mail.ru},
publisher={Springer Netherlands},
issn={13895729},
coden={BIOGC},
pubmed_id={26423570},
language={English},
abbrev_source_title={Biogerontology},
document_type={Article},
source={Scopus},
}



@ARTICLE{Vasllev201611,
author={Vasllev, A.G. and Trashkov, A.P. and Verlov, N.A. and Kovalenko, A.L. and Petrov, A.Yu. and Valeev, V.V.},
title={Assessment of specific pharmacologic activity of unifusol on endothelium dysfunction model induced by n-nitro-l-arginine methyl ether},
journal={Eksperimental'naya i Klinicheskaya Farmakologiya},
year={2016},
volume={79},
number={11},
pages={11-14},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&partnerID=40&md5=18fb70c18a00b0d7533945e24d527a58},
affiliation={M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, ul. Maurice Thorez44, St. Petersburg, 194223, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, ul. Bekhtereva 1, St. Petersburg, 192019, Russian Federation},
abstract={Specific pharmacologic activity of sodium-L-arginine succinate (unifusol) was studied on endothelium dysfunction model (EDM) in rats. EDM was induced by daily administration of N-nitro-L-arginine methyl ether (L-NAME). The effectiveness of experimental therapy with unifusol was assessed by changes in the arterial pressure level, duration of endothelium-dependent and -independent vasodilation, and the blood concentration of endothelial dysfunction markers including VEGF, NO, endothelin-1 and the number of desquamated endotheliocytes. Administration of unifusol favors correction of blood vessel endothelium state as manifested by normalization of its functional activity and reduction of the apoptosis of endotheliocytes. In addition, the obtained results unambiguously confirm considerable vasodilating and antihypertensive effects of unifusol.},
author_keywords={Arterial hypertension;  Endothelial dysfunction;  Rats;  Sodium-L-arginine succinate;  Unifusol;  Vasodilation},
publisher={Izdatel'stvo Meditsina},
issn={08692092},
pubmed_id={29791109},
language={Russian},
abbrev_source_title={Eksp. Klinicheskaya Farmakol.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Valeev20169,
author={Valeev, V.V. and Trashkov, A.P. and Kovalenko, A.L. and Vasil'ev, A.G.},
title={Pathophysiological and clinical aspects of using L-arginine in cardiology and angiology [Patofiziologicheskie i klinicheskie aspekty primeneniia L-arginina v kardiologii i angiologii]},
journal={Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery},
year={2016},
volume={22},
number={3},
pages={9-15},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&partnerID=40&md5=0a98563798c83c8637d1362f919aff13},
affiliation={Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation; Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation; Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation},
abstract={Presented herein is a review of scientific publications dedicated to studying the pharmacodynamics of L-arginine and possibilities of its clinical application. Interest to L-arginine is associated, first of all, with its role as a precursor in endogenous synthesis of nitric oxide (NO), playing an important role in regulation of the functional state of the vascular wall. According to numerous studies, oral and parenteral administration of L-arginine restores endothelial production of NO in such diseases as atherosclerosis, hypertension, type 2 diabetes mellitus, obliterating diseases of arteries of lower extremities. The NO-mediated effect of L-arginine manifests itself in increasing the capability of vessels to dilatation, decreasing blood platelet aggregation, and inhibiting proliferation of smooth muscle cells of vessels. The effect is most pronounced in patients presenting with hypercholesterolaemia and initially decreased reactivity of the blood channel. The mostly pronounced NO-mediated effect of L-arginine is observed in parenteral route of its administration. Prolonged administration of L-arginine slows down progression of atherosclerosis.},
issn={10276661},
pubmed_id={27626244},
language={Russian},
abbrev_source_title={Angiol Sosud Khir},
document_type={Review},
source={Scopus},
}





@ARTICLE{Erkudov201645,
author={Erkudov, V.O. and Pugovkin, A.P. and Verlov, N.A. and Sergeev, I.V. and Ievkov, S.A.},
title={Systemic errors in the estimation of systemic arterial pressure via transfer functions after experimental changes of the circulating blood volume},
journal={Patologicheskaia fiziologiia i eksperimental'naia terapiia},
year={2016},
volume={60},
number={1},
pages={45-49},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&partnerID=40&md5=6367ac191f1141256d9dbfd57e6f43a1},
abstract={The results of the experimental studies reveal the decrease of vascular rigidity with the increase of systemic error of the arterial pressure values estimated via implication of transfer functions following haemorrhage modeling in rats. Compensation of the circulating blood volume by means of dextran infusion resulted in restoration of both vascular rigidity and systemic error of estimated arterial pressure. The results can be put into medical practice as an approach for testing of non-invasive methods in cardiovascular research.},
issn={00312991},
pubmed_id={29215248},
language={Russian},
abbrev_source_title={Patol Fiziol Eksp Ter},
document_type={Article},
source={Scopus},
}



@ARTICLE{Trashkov201634,
author={Trashkov, A.P. and Vasil'Ev, A.G. and Kovalenko, A.L. and Petrov, A.Yu. and Valeev, V.V.},
title={Influence of angioprotector drugs on the efficacy of cytostatic therapy (experimental study)},
journal={Eksperimental'naya i Klinicheskaya Farmakologiya},
year={2016},
volume={79},
number={2},
pages={34-39},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&partnerID=40&md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4},
affiliation={St. Petersburg State Pediatric Medical University, Ul. Litovskaya 2, St.-Petersburg, 194100, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, Ul. Bekhtereva 1, St.-Petersburg, 192019, Russian Federation},
abstract={The influence of angioprotector and endothelium-protector drugs pentoxifylline and unifuzol as components of supportive therapy on the efficacy of combined cytostatic treatment has been experimentally studied. It is established that pentoxifylline and unifuzol do not affect the antitumor and antimetastatic activity of doxorubicin and cyclophosphan with respect to Pliss lymphosarcoma and Walker 256 carcinosarcoma, and in some cases even potentiate the effect of cytostatic therapy.},
author_keywords={Cytostatic therapy;  Pentoxifylline;  Pliss lymphosarcoma;  Succinic acid;  Tumor;  Unifuzol;  Walker 256 carcinosarcoma},
publisher={Izdatel'stvo Meditsina},
issn={08692092},
pubmed_id={27416681},
language={Russian},
abbrev_source_title={Eksp. Klinicheskaya Farmakol.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Odinak20169,
author={Odinak, M.M. and Voznyuk, I.A. and Yanishevsky, S.N. and Golokhvastov, S.Y. and Tsygan, N.V. and Polushin, A.Yu. and Andreev, R.V. and Mirnaya, D.A.},
title={Opportunities in multimodal neuroimaging for optimizing thrombolytic therapy for ischemic stroke},
journal={Nevrologiya, Neiropsikhiatriya, Psikhosomatika},
year={2016},
volume={8},
number={1},
pages={9-15},
doi={10.14412/2074-2711-2016-1-9-15},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&doi=10.14412%2f2074-2711-2016-1-9-15&partnerID=40&md5=f1c8a704d6aab179148bfb1ddbad5891},
affiliation={S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg, 6, Academician Lebedev St., Saint Petersburg, 194044, Russian Federation},
abstract={The main purpose of examination of patients before thrombolytic therapy for ischemic stroke (IS) is to timely identify contraindications to the use of recombinant tissue plasminogen activator. Objective: to estimate opportunities and benefits in applying multimodal magnetic resonance imaging (MRI) to improve clinical outcomes in acute stroke, among other processes, by enhancing the efficiency and safety of thrombolytic therapy. Patients and methods. The clinical experience of the S.M. Kirov Military Medical Academy in using multimodal MRI of the brain since 2004 was analyzed in patients with stroke. Results. Comprehensive assessment of the results of perfusion-weighted MRI of the brain and those of transcranial Doppler ultrasound identified five clinically significant variants of perfusion changes in IS: normal perfusion; postischemic hyperemia; persistent hypoperfusion; acute pathological hyperperfusion, and unrecovered perfusion. With an irreversible tissue damage volume of &gt;60 cm3 on day 1 of stroke, as evidenced by diffusion-weighted MRI, the odd ratio for cerebral edema in the acutest period of the disease is 39.4% (95% CI 2.57-2436; p&lt;0.05). The risk of hemorrhagic transformation increases with a measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct &lt;35×10-5 mm2/sec within the first 24 hours after disease onset (p&lt;0.005). Conclusion. The data of local clinical practice and the results of international clinical trials show that multimodal MRI of the brain is a reliable tool for the detailed evaluation of the expected efficiency and safety of thrombolytic therapy for IS. When persistent hypoperfusion is detected, the determination of perfusion-diffusion mismatch is of no informative value in deciding on whether thrombolytic therapy can be performed. Estimating the volume of pathological changes on diffusion-weighted images and the measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct in the measured diffusion coefficient maps allows the risk of major intracranial complications due to IS to be identified.},
author_keywords={Diffusionweighted magnetic resonance imaging;  Intracranial complications due to stroke;  Ischemic stroke;  Multimodal neuroimaging;  Perfusion-weighted magnetic resonance imaging;  Thrombolytic therapy;  Variants of perfusion changes},
correspondence_address1={Yanishevsky, S.N.; S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg, 6, Academician Lebedev St., Russian Federation; email: stasya71@yandex.ru},
publisher={Ima-Press Publishing House},
issn={20742711},
language={Russian},
abbrev_source_title={Nevrol. Neiropsikhiatr. Psikhosomat.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Karabanov2015691,
author={Karabanov, S.M. and Verlov, N.A. and Suvorov, D.V. and Gololobov, G.P. and Slivkin, E.V.},
title={Properties of contact coatings based on ruthenium nanofilms for MEMS switches},
journal={Technical Physics Letters},
year={2015},
volume={41},
number={7},
pages={691-693},
doi={10.1134/S1063785015070226},
note={cited By 2},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&doi=10.1134%2fS1063785015070226&partnerID=40&md5=7efd35505f6a5b7c2f8c867e82b0ac4a},
affiliation={Ryazan State Radioengineering University, Ryazan, 390005, Russian Federation},
abstract={Switching properties of contact coatings based on ruthenium nanofilms obtained by electrochemical deposition have been studied. The laws of variation of the contact resistance as a function of the number of switching cycles are established as dependent on the coating thickness and surface roughness. Optimum parameters of contact coatings are determined that ensure minimum contact resistance of switches for micro-electromechanical systems (MEMS) operating in steady-state regimes. © 2015, Pleiades Publishing, Ltd.},
correspondence_address1={Suvorov, D.V.; Ryazan State Radioengineering UniversityRussian Federation},
publisher={Maik Nauka-Interperiodica Publishing},
issn={10637850},
language={English},
abbrev_source_title={Tech. Phys. Lett.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Odinak2015600,
author={Odinak, M.M. and Yanishevskii, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Voznyuk, I.A. and Trufanov, A.G.},
title={Use of Succinates for Correction of Metabolic Impairments in the Ischemic Penumbra Zone in Stroke Patients},
journal={Neuroscience and Behavioral Physiology},
year={2015},
volume={45},
number={5},
pages={600-604},
doi={10.1007/s11055-015-0118-4},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&doi=10.1007%2fs11055-015-0118-4&partnerID=40&md5=985c7310b65123e7f0e76e00e7df1c26},
affiliation={Department of Nervous Diseases, Kirov Military Medical Academy, St. Petersburg, Russian Federation},
abstract={The aim of the present work was to use MR spectroscopy to assess the quantitative contents and ratios of different metabolites in the infarct nucleus, ischemic penumbra, and unaltered tissue in the opposite hemisphere in patients in the acute period of ischemic stroke. A total of 72 patients were studied, of whom 37 (the study group) received the antioxidant Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) in addition to basal treatment, while 35 patients received only standard treatment without use of antioxidants. Stroke severity was assessed on the NIHSS scale and functional outcomes on day 30 were evaluated using the Bartel index and modified Rankin scale. MR proton spectroscopy was performed twice: during the first 24 h of disease onset and on day 5. Use of the succinate-containing antioxidant Mexidol (500 mg i.v. for 14 days) during the acute period of ischemic stroke significantly decreased the intracellular lactate (p = 0.002) and inositol contents (p = 0.005) from the levels in the control group, which helped restore the balance between the aerobic and anaerobic mechanisms of oxidation and had favorable influences on the rehabilitation potentials of the patients. A positive correlation was found between the lactate content in the ischemic penumbra zone and values on the NIHSS (r = 0.5786, p = 0.049), along with a negative correlation between the lactate content in the ischemic penumbra zone and the level of functional recovery assessed on the Bartel index (r = –0.6305, p = 0.028), which supports the existence of an interaction between impaired glucose metabolism in hypoxic conditions and the level of injury to nervous tissue. © 2015, Springer Science+Business Media New York.},
author_keywords={antioxidants;  ischemic stroke;  magnetic resonance spectroscopy;  Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate)},
correspondence_address1={Yanishevskii, S.N.; Department of Nervous Diseases, Kirov Military Medical AcademyRussian Federation; email: stasya71@yandex.ru},
publisher={Springer New York LLC},
issn={00970549},
coden={NBHPB},
language={English},
abbrev_source_title={Neurosci. Behav. Physiol.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Trashkov2015497,
author={Trashkov, A.P. and Panchenko, A.V. and Kayukova, E.S. and Korablev, R.V. and Pechatnikova, V.A. and Vasil’ev, A.G. and Anisimov, V.N.},
title={P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation},
journal={Bulletin of Experimental Biology and Medicine},
year={2015},
volume={158},
number={4},
pages={497-499},
doi={10.1007/s10517-015-2793-0},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&doi=10.1007%2fs10517-015-2793-0&partnerID=40&md5=aa6957c053dc95e316a5743556578173},
affiliation={St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation; N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation},
abstract={Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia. © 2015, Springer Science+Business Media New York.},
author_keywords={hemostasis;  neoangiogenesis;  P-388 leukemia;  tumor;  vascular endothelial growth factor},
correspondence_address1={Trashkov, A.P.; St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian FederationRussian Federation; email: alexandr.trashkov@gmail.com},
publisher={Springer New York LLC},
issn={00074888},
coden={BEXBA},
pubmed_id={25708334},
language={English},
abbrev_source_title={Bull. Exp. Biol. Med.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Tsygan2015112,
author={Tsygan, N.V. and Trashkov, A.P. and Yakovleva, V.A. and Malkova, V.M. and Gracheva, E.V. and Kovalenko, A.L. and Vasiliev, A.G.},
title={Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke},
journal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},
year={2015},
volume={2015},
number={7},
pages={112-116},
doi={10.17116/jnevro201511571112-116},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&doi=10.17116%2fjnevro201511571112-116&partnerID=40&md5=d627b1d1e0674d0be3e6fa7af2c09a99},
affiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation; St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation; Institute of Toxicology of the Federal Medical-Biological Agency, St. Petersburg, Russian Federation},
abstract={Objective. To explore the endogenous and pharmacological activation of neurotrophic mechanisms in a model of brain ischemic lesion in rats. Material and methods. The study was performed on 170 male albino rats (195-205 g). The model of ischemic stroke was accomplished by the electrocoagulation of the proximal segment of the left middle cerebral artery and simultaneous permanent ligation of the left common carotid artery. Results and conclusion. The evaluation of NSE, NO, VEGF, NGF levels in the brain cytoplasmic lysate and plasma showed the delayed activation of neurotrophic mechanisms in astrocytes accompanied by a decrease in delayed alteration of neurons. The use of cytoflavin in the treatment of stroke was accompanied by the earlier and more intense activation of neurotrophic mechanisms in astrocytes, delayed activation of neurotrophic mechanisms in endothelial cells, which promoted neuroprotection in acute ischemic stroke. © 2015, Media Sphera. All rights reserved.},
author_keywords={Cytoflavin;  Endothelial dysfunction;  Ischemic stroke;  Multimodal cytoprotection;  Neurotrophic factors;  Neurotrophic mechanisms},
publisher={Media Sphera},
issn={19977298},
pubmed_id={26356524},
language={Russian},
abbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},
document_type={Article},
source={Scopus},
}



@ARTICLE{Trashkov2015642,
author={Trashkov, A.P. and Panchenko, A.V. and Korablev, R.V. and Yurova, M.N. and Egormin, P.A. and Chernenko, N.A. and Gpopovich, I. and Tyndyk, M.L. and Verlov, N.A. and Artemenko, M.R. and Vasiliev, A.G. and Anisimov, V.N.},
title={Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice},
journal={Voprosy Onkologii},
year={2015},
volume={61},
number={4},
pages={642-646},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&partnerID=40&md5=25700032627eb71d9f9c0243ffa43e26},
affiliation={State Pediatric Medical University, Russian Federation; N.N.Petrov Research Institute of Oncology, St.-Petersburg, Russian Federation},
abstract={Age-dependent angiogenesis intensity changes have been studied in transgenic HER-2/neu (FBV/N) mice characteristic of breast tumors' high incidence with hyperexpression of HER- 2/neu. Concentration of vascular endothelial growth factor, insulin-dependent growth factor 1, nitrogen monoxide, tissue plasminogen activator and type 1 plasminogen activator inhibitor were assessed by means of immune-enzyme assay. The results testify to angiogenesis processes activation side by side with aging and growth of the tumors. Maximum manifestation of these disturbances (growth factors' blood concentrations increase and endotheliocytes' functional activity inhibition) has been revealed in 6-month-oId mice during neoplasma maximum intensive and aggressive growth period.},
author_keywords={Age-dependent changes;  Angiogenesis;  Biomodeling;  Breast tumors;  Hemostasis;  HER- 2/neu;  IGF-1;  PAI-1;  TPA;  VEGF},
publisher={Izdatel'stvo Meditsina},
issn={05073758},
coden={VOONA},
pubmed_id={26571837},
language={Russian},
abbrev_source_title={Vopr. Onkol.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Trashkov201517,
author={Trashkov, A.P. and Vasiliev, A.G. and Kovalenko, A.L. and Tagirov, N.S.},
title={Metabolic therapy of nephrolithiasis in two different rat models of kidney disease},
journal={Eksperimental'naya i Klinicheskaya Farmakologiya},
year={2015},
volume={78},
number={3},
pages={17-21},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&partnerID=40&md5=84ca1147478becd454660d7e67dfab73},
affiliation={Saint-Petersburg State Pediatric Medical University, Russian Federation; Toxicological Institute of Federal Medical Biological Agency, Russian Federation},
abstract={108 albino male rats were used in two experimental rat models reproducing urolithiasis for the assessment of metabolic drug medicine Remaxol nephroprotecti-ve effect upon the development of this disease. "Ethyleneglycol" model consisted of adding 1 % ethylene glycol solution in drinking water for 37 days and "fructose-induced" one-of adding 10 % fructose solution in drinking water for the same period. Therapy included a 10-day course of daily i.v. injections of Remaxol (14 ml/kg). Both experimental models were successful in producing urolithiasis with considerable disturbances in the structure and functioning of kidneys up to revealing microconcrement formation. The "ethyleneglycol" model proved to cause maximum changes while the "Fructose-induced" model-only moderate ones. Metabolic correction of these changes was successful in nephroprotection effectively normalizing kidney functions and the total protein concentration, eliminating hyperglycemia and reducing creatinine and urea blood plasma concentration in both rat experimental models.},
author_keywords={Experimental urolithiasis models;  Metabolic medicines;  Nephroprotection;  Rats;  Remaxol;  Urolithiasis},
publisher={Izdatel'stvo Meditsina},
issn={08692092},
pubmed_id={26036006},
language={Russian},
abbrev_source_title={Eksp. Klinicheskaya Farmakol.},
document_type={Article},
source={Scopus},
}



@ARTICLE{Anisimov201546,
author={Anisimov, V. and Popovich, I.G. and Zabezhinski, M.A. and Egormin, P.A. and Yurova, M.N. and Semenchenko, A.V. and Tyndyk, M.L. and Panchenko, A.V. and Trashkov, A.P. and Vasiliev, A.G. and Khaitsev, N.V.},
title={Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973308},
journal={Cell Cycle},
year={2015},
volume={14},
number={1},
pages={46-55},
doi={10.4161/15384101.2014.973308},
note={cited By 21},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&doi=10.4161%2f15384101.2014.973308&partnerID=40&md5=49a3af703f203dd6654be7b4c2fc0bb3},
affiliation={N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation; St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation},
abstract={The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of energy and metabolic homeostasis. We hypothesized that neonatal treatment with antidiabetic drug biguanide metformin would positively modify regulation of growth hormone - IGF-1 -insulin signaling pathway slowing down aging and improving cancer preventive patterns in rodents. To test this hypothesis male and female 129/Sv mice were s.c. injected with metformin (100 mg/kg) at the 3rd, 5th and 7th days after birth. Metformin-treated males consumed less food and water and their body weight was decreased as compared with control mice practically over their entire lifespan. There were no significant differences in age-related dynamics of food and water consumption in females and they were heavier than controls. The fraction of mice with regular estrous cycles decreased with age and demonstrated a tendency to decrease in the females neonatally treated with metformin. Neonatal exposure to metformin practically failed to change the extent of hormonal and metabolic parameters in blood serum of male and female mice. In males, neonatal metformin treatment significantly increased the mean life span (C20%, P < 0.05) and slightly increased the maximum life span (C3.5%). In females, the mean life span and median in metformin-treated groups were slightly decreased (-9.1% and -13.8% respectively, P > 0.05) in comparison to controls, whereas mean life span of last 10% survivors and maximum life span were the same as in controls. Almost half (45%) of control male mice and 71.8% male mice neonatally exposed to metformin survived up to 800 d of age, the same age was achieved by 54.3% of mice in control female group and 30% of metformin-treated females (P < 0.03). Thus, neonatal metformin exposure slows down aging and prolongs lifespan in male but not in female mice. © 2015 Taylor & Francis Group, LLC.},
author_keywords={Biomarkers of aging;  Carcinogenesis;  Gender;  Life extension;  Metformin;  Mice;  Neonatal},
funding_details={Ministry of Education and Science of the Russian Federation11–04–003472},
}

@ARTICLE{Tsygan201434,
author={Tsygan, N.V. and Trashkov, A.P.},
title={[Pathogenic variants of brain injuries and pharmalogic cerebroprotection performed on the model of brain condition during cardiovascular bypass surgery]},
journal={Voenno-medit͡sinskiĭ zhurnal},
year={2014},
volume={335},
number={10},
pages={34-45},
note={cited By 1},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&partnerID=40&md5=4d3932101742b08acb0601cf554911b0},
abstract={Developed and approved a pathogenic grounded experimental model of brain condition during cardiovascular bypass surgery. Undertaken in Wistar rats research allowed to evaluate in detail effectiveness and safety of protracted cerebroprotective treatment. Advantages of this model are researches in laboratory animals with the aim to research condition of nerve tissue, not intensive procedures and consequently high reproducibility and possibility of complex evaluation of changes at every stage of research. Results of neurons, neuroglia and activation of neurotrophic mechanisms prove that simulation of brain condition during cardiovascular bypass surgery is accompanied with acute and delayed brain injuries. Use of Cytoflavin under pharmalogic cerebroprotection had prolonged multimodal and neuroprotactive effect, leading to improvement of neurotrophic protection from the first days.},
issn={00269050},
pubmed_id={25532310},
language={Russian},
abbrev_source_title={Voen Med Zh},
document_type={Article},
source={Scopus},
}



@ARTICLE{Tsygan201310,
author={Tsygan, N.V. and Trashkov, A.P.},
title={[Brain functional state and cytoprotective potential in model of acute cerebral hypoxia (experimental research)].},
journal={Patologicheskaia fiziologiia i èksperimental'naia terapiia},
year={2013},
number={4},
pages={10-16},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&partnerID=40&md5=29ed65140755fb5ce34683dfae316e97},
abstract={The functional state of the brain and the potential of pharmacologic cytoprotection after an acute cerebral hypoxia were studied. The experiment involved 186 adult male rats. The rats in experimental groups underwent acute thromboembolism of the right carotid artery. The functional state of the brain and the efficacy and safety of the Cytoflavin complex cytoprotective drug treatment had been analyzed over the 10 days following the thromboembolism. A neurological examination was accomplished daily, the serum levels of NSE, GFAP, S100beta and brain cytolysate levels of NSE were measured on the 1st, 3rd, 10th day. The NSE brain cytolysate level went up on the 1st day and the NSE serum level was up on the 3rd day following the thromboembolism, which may have indicated an acute delayed alteration of neurons and an increase of the blood-brain barrier permeability on the 3rd day after the thromboemboIism. Neuroglial biomarkers went up on the 1st (GFAP), 3rd and 10th (S100beta) day, which indicated an acute delayed alteration and/or activation of glial cells. Therefore, the applied experimental model promotes acute delayed alteration of neurons and neuroglia with a possible activation of the latter. The Cytoflavin proved to have a cytoprotective effect on neurons and to diminish the alteration and/or activation of glial cells over the observed period after the acute thromboembolism of the carotid artery.},
correspondence_address1={Tsygan, N.V.},
issn={00312991},
pubmed_id={24640767},
language={Russian},
abbrev_source_title={Patol Fiziol Eksp Ter},
document_type={Article},
source={Scopus},
}



@ARTICLE{Odinak201359,
author={Odinak, M.M. and Shamreǐ, V.K. and Chudinovskikh, A.G. and Goncharenko, A.I. and Tsygan, N.V.},
title={[Stages of formation and development of the national military neurology and psychiatry].},
journal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},
year={2013},
volume={334},
number={12},
pages={59-67},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&partnerID=40&md5=4c2de30409d0313ab295d6591e18b4c3},
abstract={The article is devoted to the stages of formation and development of military neurology and psychiatry in Russia. Scholars of anxiety and mental disorders department of the Medical and Surgical Academy (Military Medical) made great contribution to development of scientific and organizational peculiarities of these medical disciplines and many other allied studies. Authors analyze the contribution of military psychiatrists and neurologists to the modern concept of mental care delivery in peace and wartime, research focus ares and prospects of its development.},
correspondence_address1={Odinak, M.M.},
issn={00269050},
pubmed_id={24738283},
language={Russian},
abbrev_source_title={Voen Med Zh},
document_type={Article},
source={Scopus},
}



@ARTICLE{Odinak201355,
author={Odinak, M.M. and Yanishevskiǐ, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Vozniuk, I.A. and Trufanov, A.G.},
title={The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke},
journal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},
year={2013},
volume={2013},
number={12},
pages={55-60},
note={cited By 4},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&partnerID=40&md5=8188c3acced00cf4b96d213bf98cdab0},
affiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation},
abstract={The aim of the study was to determine the quantitative content and correlation between metabolites in the core ischemic zone, the ischemic penumbra and the intact tissue of the opposite hemisphere in the acute stage of ischemic stroke using MR-spectroscopy. We studied 72 patients, including 37 patients (the main group) treated with the antioxidant mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate) in addition to standard therapy and 35 patients who received standard therapy only. The severity of stroke was assessed using the NIHSS. The Barthel index and Rankin scale were used to evaluate functional outcome in the 30th day, hydrogen MR-spectroscopy was used twice: in the first 24 h from disease onset and in the 5th day. Mexidol used in dose 500 mg intravenously during 14 days reduced significantly the content of lactate (p=0.002) and inositol (p=0.005) in the cells compared to the control group that enhanced the restoration of the balance between aerobic and anaerobic mechanisms of oxidation and positively influenced on the rehabilitation of patients. Positive correlations between the content of lactate in the ischemic penumbra and NIHSS scores (r=0.5786; p=0.049) and the negative correlation between the content of lactate in the ischemic penumbra and the degree of functional restoration assessed by the Barthel index (r= -0.6305; p=0.028) were found. These findings support the evidence for the interaction between the disturbance of glucose metabolism in conditions of hypoxia and the degree of nervous tissue damage.},
author_keywords={Antioxidants;  Ischemic stroke;  Magnetic resonance spectroscopy;  Mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate)},
issn={19977298},
pubmed_id={24430036},
language={English},
abbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},
document_type={Article},
source={Scopus},
}



@ARTICLE{Odinak201234,
author={Odinak, M.M. and Neznanov, N.G. and Chudinovskih, A.G. and Tsygan, N.V.},
title={Vladimir Mikhailovitch Bekhterev - The founder of the clinical neuropsychiatry},
journal={Vestnik Rossiiskoi Akademii Meditsinskikh Nauk},
year={2012},
number={8},
pages={34-39},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&partnerID=40&md5=68d718e3c50f74bbb80b865028640312},
affiliation={Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg, Russian Federation; Saint Petersburg Neuropsychiatry Research Institute n.a. V.M. Bekhterev, Russian Federation},
abstract={The article presents main milestones in the career of Vladimir Mikhailovitch Bekhterev. The research in anatomy and physiology of the brain performed by V.M. Bekhterev gave original data of worldwide priority. V.M. Bekhterev significantly improved methodology of neurological examination and differential diagnosis in clinical neuropsychiatry. The scientific heritage of V.M. Bekhterev proves his outstanding role in establishment and development of the neuropsychiatry.},
author_keywords={Clinical neuropsychiatry;  History of neurology;  History of psychiatry;  V.M. Bekhterev},
correspondence_address1={Odinak, M.M.; Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg, Russian Federation},
issn={08696047},
pubmed_id={23166987},
language={Russian},
abbrev_source_title={Vestn. Ross. Akad. Med. Nauk},
document_type={Article},
source={Scopus},
}



@ARTICLE{Tsygan201242,
author={Tsygan, N.V.},
title={[The algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass].},
journal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},
year={2012},
volume={333},
number={6},
pages={42-46},
note={cited By 4},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&partnerID=40&md5=f5cb15bc2be8c2ca5685a1ed11bce224},
abstract={The article presents the algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass, based on contemporary concept of intraoperative brain damage pathogenesis. The algorithm includes clinical, laboratory and instrumental diagnostic procedures in the perioperative period. The article shows the prospects of the use of the algorithm for optimizing neuroprotection and outcomes in cardiac surgery and acute stroke.},
correspondence_address1={Tsygan, N.V.},
issn={00269050},
pubmed_id={22888701},
language={Russian},
abbrev_source_title={Voen Med Zh},
document_type={Review},
source={Scopus},
}



@ARTICLE{Khubulava201129,
author={Khubulava, G.G. and Ivchenko, E.V. and Paǐvin, A.A. and Kravchuk, V.N. and Iurchenko, D.L. and Ivashchenko, A.I. and Didenko, M.V. and Luk'ianov, N.G. and Peleshok, A.S. and Tsygan, N.V. and Liubimov, A.I. and Naumov, A.B. and Shorokhov, K.H. and Sukharev, A.E. and Kniazev, E.A. and Porembskaia, I.A.},
title={[Experience of left ventricular assist device "Incor" as "bridge to recovery" implantation in patients with end stage congestive heart failure].},
journal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},
year={2011},
volume={332},
number={11},
pages={29-35},
note={cited By 0},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&partnerID=40&md5=e62a131bbea78ac2407104486e0adcf2},
abstract={Left ventricular assist device "Incor" ("Berlinhear", Germany) implantation experience in patient with ischemic cardiomiopathy and severe congestive heart failure is presented. Left ventricular assist device implantation was followed by coronary artery bypass grafting simultaneously. Total assist time was 211 days. Complications developed during assisting time are shown. After Left ventricular assist device explantation three chamber pacemaker was implanted as cardiac resynchronization therapy. Left ventricular end diastolic size decreased (from 78 to 70 mm), ejection fraction increased (from 19 to 35%) during assist time.},
correspondence_address1={Khubulava, G.G.},
issn={00269050},
pubmed_id={22329169},
language={Russian},
abbrev_source_title={Voen Med Zh},
document_type={Article},
source={Scopus},
}



@ARTICLE{Odinak201029,
author={Odinak, M.M. and Skvortsova, V.I. and Vosniuk, I.A. and Rumiantseva, S.A. and Stakhovskaya, L.V. and Klocheva, E.G. and Novikova, L.B. and Yanishevsky, S.N. and Golokhvastov, S.Y. and Tsygan, N.V.},
title={Efficacy of cytoflavin in patients in the acute ischemic stroke},
journal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},
year={2010},
volume={110},
number={12},
pages={29-36},
note={cited By 3},
url={https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&partnerID=40&md5=3feeb5bc96137ec07e6c36691bccf7b4},
abstract={We present the results of a multicenter study on efficacy of cytoflavin in the treatment of patients with acute ischemic stroke. Seventy patients (41 of the main group and 29 of the control group) were enrolled in the study. All patients received basic therapy aimed at improving systemic hemodynamics, rheological blood properties and at the prevention of stroke complications. Patients of the main group were treated with cytoflavin as follows: days 1-10 - 20 ml (in 400 ml of the 0,9% NaCl solution) twice a day intravenously in drops; days 11-35 - 850 mg twice a day. We assessed the dynamics of restoration of lost functions (NIHSS, the Rankin scale, the Barthel index) and volumes of ischemic lesion (MRI T1-, T2-, diffusion-weighted images). Results of the study on patients of the control group were supplemented with literature data about 306 patients studied using clinical scales and 40 patients studied with MRI. We revealed a trend towards an effect of cytoflavin on the preservation of brain matter in the acute phase of stroke. Cytoflavin reduced the neurological deficit and improved activities of daily living in patients that may be explained by the less brain damage.},
author_keywords={Brain infarction volume;  Cytoflavin, antioxidant;  Ischemic stroke;  Magnetic resonance tomography},
correspondence_address1={Stakhovskaya, L. V.email: nabi@orc.ru},
issn={19977298},
pubmed_id={21311484},
language={English},
abbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},
document_type={Article},
source={Scopus},
}
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In order to keep using Mendeley with BibBase past April\n        14th, you need to:\n        <ol>\n          <li>renew the authorization for BibBase on Mendeley, and</li>\n          <li>update the BibBase URL\n            in your page the same way you did when you initially set up\n            this page.\n          </li>\n        </ol>\n      </p>\n\n      <p>\n        <a href=\"http://bibbase.org/cgi-bin/mendeley2/get.py\">\n          <i class=\"fa fa-angle-double-right\"></i>\n          Fix it now</a>\n      </p>\n    </div>\n\n  </div>\n\n\n  <div id=\"bibbase_body\">\n    \n  \n  <div class=\"bibbase_group_whole\" id=\"group_2019\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2019')\"\n      onkeypress=\"toggleGroup('group_2019')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2019</span>\n      <span class=\"bibbase_group_count\">\n        \n        (2)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"anonymous-autoimmunityinacuteischemicstrokeandtheroleofbloodbrainbarrierthedarksideorthelightone-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064341869&amp;doi=10.1007%2fs11684-019-0688-6&amp;partnerID=40&amp;md5=4e09f1f2e1fb7a496df0344ab1b0ee31\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'anonymous-autoimmunityinacuteischemicstrokeandtheroleofbloodbrainbarrierthedarksideorthelightone-2019', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064341869&amp;doi=10.1007%2fs11684-019-0688-6&amp;partnerID=40&amp;md5=4e09f1f2e1fb7a496df0344ab1b0ee31', event);\">\n    Autoimmunity in acute ischemic stroke and the role of blood-brain barrier: the dark side or the light one?.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  \n</span>\n\n  \n\n</span>\n\n  <i>Frontiers of Medicine</i>, 13(4): 420-426.  2019.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064341869&amp;doi=10.1007%2fs11684-019-0688-6&amp;partnerID=40&amp;md5=4e09f1f2e1fb7a496df0344ab1b0ee31\"\n     onclick=\"log_download('anonymous-autoimmunityinacuteischemicstrokeandtheroleofbloodbrainbarrierthedarksideorthelightone-2019', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064341869&amp;doi=10.1007%2fs11684-019-0688-6&amp;partnerID=40&amp;md5=4e09f1f2e1fb7a496df0344ab1b0ee31', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Autoimmunity in acute ischemic stroke and the role of blood-brain barrier: the dark side or the light one? [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1007/s11684-019-0688-6\"\n     onclick=\"log_download('anonymous-autoimmunityinacuteischemicstrokeandtheroleofbloodbrainbarrierthedarksideorthelightone-2019', 'http://doi.org/10.1007/s11684-019-0688-6', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/anonymous-autoimmunityinacuteischemicstrokeandtheroleofbloodbrainbarrierthedarksideorthelightone-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('anonymous-autoimmunityinacuteischemicstrokeandtheroleofbloodbrainbarrierthedarksideorthelightone-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\"></pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  This article presents a synopsis of the current data on the mechanisms of blood-brain barrier (BBB) alteration and autoimmune response in acute ischemic stroke. Most researchers confirm the relationship between the severity of immunobiochemical changes and clinical outcome of acute ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation, which alters the brain tissue and exposes the co-stimulatory molecules of the immune system and the neuronal antigens. To date, BBB is not considered the border between the immune system and central nervous system, and the local immune subsystems are found within and behind the BBB. BBB disruption contributes to the leakage of brain autoantigens and induction of secondary autoimmune response to neuronal antigens and long-term inflammation. Glymphatic system function is altered and jeopardized both in hemorrhagic and ischemic stroke types. The receptors of innate immunity (toll-like receptor-2 and toll-like receptor-4) are also involved in acute ischemia-reperfusion injury. Immune response is related to the key processes of blood clotting and fibrinolysis. At the same time, the stroke-induced immune activation may promote reparation phenomena in the brain. Subsequent research on the reduction of the acute ischemic brain injury through the target regulation of the immune response is promising. © 2019, Higher Education Press and Springer-Verlag GmbH, Germany, part of Springer Nature.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"litvinenko-odinak-tsygan-andreev-peleshok-kurasov-yakovleva-ryabtsev-characteristicsofpostoperativecerebraldysfunctiondependingonthetypeandpositionoftheimplantedprostheticheartvalve-2019\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&amp;doi=10.17116%2fjnevro201911902118&amp;partnerID=40&amp;md5=361a4ae7b1be819ac3bf90149cfd0de6\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'litvinenko-odinak-tsygan-andreev-peleshok-kurasov-yakovleva-ryabtsev-characteristicsofpostoperativecerebraldysfunctiondependingonthetypeandpositionoftheimplantedprostheticheartvalve-2019', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&amp;doi=10.17116%2fjnevro201911902118&amp;partnerID=40&amp;md5=361a4ae7b1be819ac3bf90149cfd0de6', event);\">\n    Characteristics of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Litvinenko, I.; Odinak, M.; Tsygan, N.; Andreev, R.; Peleshok, A.; Kurasov, E.; Yakovleva, V.;  and Ryabtsev, A.\n</span>\n\n  \n\n</span>\n\n  <i>Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova</i>, 119(2): 18-22.  2019.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&amp;doi=10.17116%2fjnevro201911902118&amp;partnerID=40&amp;md5=361a4ae7b1be819ac3bf90149cfd0de6\"\n     onclick=\"log_download('litvinenko-odinak-tsygan-andreev-peleshok-kurasov-yakovleva-ryabtsev-characteristicsofpostoperativecerebraldysfunctiondependingonthetypeandpositionoftheimplantedprostheticheartvalve-2019', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&amp;doi=10.17116%2fjnevro201911902118&amp;partnerID=40&amp;md5=361a4ae7b1be819ac3bf90149cfd0de6', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Characteristics of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.17116/jnevro201911902118\"\n     onclick=\"log_download('litvinenko-odinak-tsygan-andreev-peleshok-kurasov-yakovleva-ryabtsev-characteristicsofpostoperativecerebraldysfunctiondependingonthetypeandpositionoftheimplantedprostheticheartvalve-2019', 'http://doi.org/10.17116/jnevro201911902118', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/litvinenko-odinak-tsygan-andreev-peleshok-kurasov-yakovleva-ryabtsev-characteristicsofpostoperativecerebraldysfunctiondependingonthetypeandpositionoftheimplantedprostheticheartvalve-2019\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('litvinenko-odinak-tsygan-andreev-peleshok-kurasov-yakovleva-ryabtsev-characteristicsofpostoperativecerebraldysfunctiondependingonthetypeandpositionoftheimplantedprostheticheartvalve-2019')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Litvinenko201918,\r\nauthor={Litvinenko, I.V. and Odinak, M.M. and Tsygan, N.V. and Andreev, R.V. and Peleshok, A.S. and Kurasov, E.S. and Yakovleva, V.A. and Ryabtsev, A.V.},\r\ntitle={Characteristics of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve},\r\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\r\nyear={2019},\r\nvolume={119},\r\nnumber={2},\r\npages={18-22},\r\ndoi={10.17116/jnevro201911902118},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062973260&amp;doi=10.17116%2fjnevro201911902118&amp;partnerID=40&amp;md5=361a4ae7b1be819ac3bf90149cfd0de6},\r\naffiliation={Kirov Military Medical Academy, St.-Petersburg, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Leningrad region, Russian Federation; Dzhanelidze St.-Petersburg Research Institute of Emergency Medicine, St.-Petersburg, Russian Federation},\r\nabstract={Objective. To study the prevalence and structure of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve in patients who underwent surgery for the acquired heart valve disease. Material and methods. The study included 115 patients (70 men and 45 women; 64 [56; 72] years old), who underwent elective replacement or repair surgery for the acquired heart valve disease. Results and conclusion. The postoperative cerebral dysfunction was diagnosed in 40.9% patients, including replacement in the aortic position (45.5%), in the mitral position (55%), in several positions (20%). Replacement surgery was accompanied by three clinical types of postoperative cerebral dysfunction and repair surgery — by deferred cognitive impairment only. Postoperative cerebral dysfunction after the replacement in the mitral position was more common (odds ratio 4.47, 95% confidence interval 1.21—18.35, p=0.041), including its acute clinical types — perioperative stroke and symptomatic delirium of the early postoperative period (p=0.029), compared to that after the repair heart valve surgery. After the replacement in the aortic position, acute clinical types of postoperative cerebral dysfunction were more common (p=0.036). After the replacement with biological prosthesis, symptomatic delirium of the early postoperative period was more common (p=0.047). The occurrence of the deferred cognitive impairment didn’t depend on the type and position of the implanted prosthetic heart valve. © 2019, Media Sphera Publishing Group. All right reserved.},\r\nauthor_keywords={Acquired heart valve disease;  Deferred cognitive impairment;  Heart valve repair surgery;  Heart valve replacement surgery;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},\r\ncorrespondence_address1={Tsygan, N.V.; Kirov Military Medical AcademyRussian Federation; email: 77tn77@gmail.com},\r\npublisher={Media Sphera Publishing Group},\r\nissn={19977298},\r\npubmed_id={30874521},\r\nlanguage={Russian},\r\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objective. To study the prevalence and structure of postoperative cerebral dysfunction depending on the type and position of the implanted prosthetic heart valve in patients who underwent surgery for the acquired heart valve disease. Material and methods. The study included 115 patients (70 men and 45 women; 64 [56; 72] years old), who underwent elective replacement or repair surgery for the acquired heart valve disease. Results and conclusion. The postoperative cerebral dysfunction was diagnosed in 40.9% patients, including replacement in the aortic position (45.5%), in the mitral position (55%), in several positions (20%). Replacement surgery was accompanied by three clinical types of postoperative cerebral dysfunction and repair surgery — by deferred cognitive impairment only. Postoperative cerebral dysfunction after the replacement in the mitral position was more common (odds ratio 4.47, 95% confidence interval 1.21—18.35, p=0.041), including its acute clinical types — perioperative stroke and symptomatic delirium of the early postoperative period (p=0.029), compared to that after the repair heart valve surgery. After the replacement in the aortic position, acute clinical types of postoperative cerebral dysfunction were more common (p=0.036). After the replacement with biological prosthesis, symptomatic delirium of the early postoperative period was more common (p=0.047). The occurrence of the deferred cognitive impairment didn’t depend on the type and position of the implanted prosthetic heart valve. © 2019, Media Sphera Publishing Group. All right reserved.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2018\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2018')\"\n      onkeypress=\"toggleGroup('group_2018')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2018</span>\n      <span class=\"bibbase_group_count\">\n        \n        (6)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"anonymous-aninexpensivemp3playerbased45khzbandnoisegeneratorforengineeringandscientificapplications-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049534345&amp;doi=10.1088%2f1742-6596%2f1038%2f1%2f012038&amp;partnerID=40&amp;md5=98e5b7679d5b1cd056c9c5aadf028dc6\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'anonymous-aninexpensivemp3playerbased45khzbandnoisegeneratorforengineeringandscientificapplications-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049534345&amp;doi=10.1088%2f1742-6596%2f1038%2f1%2f012038&amp;partnerID=40&amp;md5=98e5b7679d5b1cd056c9c5aadf028dc6', event);\">\n    An inexpensive MP3-Player based 45-kHz band noise generator for engineering and scientific applications.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  \n</span>\n\n  \n\n</span>\n\n   2018.<!-- NOTE FROM BIBBASE: This entry has an invalid bibtex entry type: conference. Therefore, we don't know how to render it properly. Please consider fixing this. -->\n  <span class=\"note\">cited By 0; Conference of International Conference PhysicA.SPb 2017 ; Conference Date: 24 October 2017 Through 26 October 2017; Conference Code:137476</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049534345&amp;doi=10.1088%2f1742-6596%2f1038%2f1%2f012038&amp;partnerID=40&amp;md5=98e5b7679d5b1cd056c9c5aadf028dc6\"\n     onclick=\"log_download('anonymous-aninexpensivemp3playerbased45khzbandnoisegeneratorforengineeringandscientificapplications-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049534345&amp;doi=10.1088%2f1742-6596%2f1038%2f1%2f012038&amp;partnerID=40&amp;md5=98e5b7679d5b1cd056c9c5aadf028dc6', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"An inexpensive MP3-Player based 45-kHz band noise generator for engineering and scientific applications [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1088/1742-6596/1038/1/012038\"\n     onclick=\"log_download('anonymous-aninexpensivemp3playerbased45khzbandnoisegeneratorforengineeringandscientificapplications-2018', 'http://doi.org/10.1088/1742-6596/1038/1/012038', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/anonymous-aninexpensivemp3playerbased45khzbandnoisegeneratorforengineeringandscientificapplications-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('anonymous-aninexpensivemp3playerbased45khzbandnoisegeneratorforengineeringandscientificapplications-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\"></pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  In this study we propose a home-made setup based on MP3 Player for producing high quality noise-like shape voltage with 45-kHz frequency band. The proposed generator's output signal is investigated both theoretically and experimentally. © Published under licence by IOP Publishing Ltd.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"anonymous-inhibitionoftaqpolymeraseactivitybysingletoxygengenerationatphotodynamictherapy-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049525797&amp;doi=10.1088%2f1742-6596%2f1038%2f1%2f012031&amp;partnerID=40&amp;md5=86c327e5db5df3e00decc0ca9c1bc4ff\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'anonymous-inhibitionoftaqpolymeraseactivitybysingletoxygengenerationatphotodynamictherapy-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049525797&amp;doi=10.1088%2f1742-6596%2f1038%2f1%2f012031&amp;partnerID=40&amp;md5=86c327e5db5df3e00decc0ca9c1bc4ff', event);\">\n    Inhibition of Taq polymerase activity by singlet oxygen generation at photodynamic therapy.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  \n</span>\n\n  \n\n</span>\n\n   2018.<!-- NOTE FROM BIBBASE: This entry has an invalid bibtex entry type: conference. Therefore, we don't know how to render it properly. Please consider fixing this. -->\n  <span class=\"note\">cited By 0; Conference of International Conference PhysicA.SPb 2017 ; Conference Date: 24 October 2017 Through 26 October 2017; Conference Code:137476</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049525797&amp;doi=10.1088%2f1742-6596%2f1038%2f1%2f012031&amp;partnerID=40&amp;md5=86c327e5db5df3e00decc0ca9c1bc4ff\"\n     onclick=\"log_download('anonymous-inhibitionoftaqpolymeraseactivitybysingletoxygengenerationatphotodynamictherapy-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049525797&amp;doi=10.1088%2f1742-6596%2f1038%2f1%2f012031&amp;partnerID=40&amp;md5=86c327e5db5df3e00decc0ca9c1bc4ff', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Inhibition of Taq polymerase activity by singlet oxygen generation at photodynamic therapy [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1088/1742-6596/1038/1/012031\"\n     onclick=\"log_download('anonymous-inhibitionoftaqpolymeraseactivitybysingletoxygengenerationatphotodynamictherapy-2018', 'http://doi.org/10.1088/1742-6596/1038/1/012031', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/anonymous-inhibitionoftaqpolymeraseactivitybysingletoxygengenerationatphotodynamictherapy-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('anonymous-inhibitionoftaqpolymeraseactivitybysingletoxygengenerationatphotodynamictherapy-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\"></pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The goal of this study was to assess the ability of singlet oxygen generated at PDT to inhibit the activity of the model enzyme - Taq polymerase. Experimentally were determined the laser irradiation dose and the singlet oxygen concentration (over 300 μM) that results to complete inhibition of Taq polymerase activity. The results show that enzymatic proteins have an order of magnitude higher susceptibility than DNA molecules to damage by singlet oxygen. © Published under licence by IOP Publishing Ltd.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"anonymous-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047785286&amp;doi=10.1134%2fS1990750818020117&amp;partnerID=40&amp;md5=8e974b0f5e74292fce4ff3287267324b\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'anonymous-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047785286&amp;doi=10.1134%2fS1990750818020117&amp;partnerID=40&amp;md5=8e974b0f5e74292fce4ff3287267324b', event);\">\n    Isolation of Extracellular Microvesicles from Cell Culture Medium: Comparative Evaluation of Methods.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  \n</span>\n\n  \n\n</span>\n\n  <i>Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry</i>, 12(2): 167-175.  2018.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047785286&amp;doi=10.1134%2fS1990750818020117&amp;partnerID=40&amp;md5=8e974b0f5e74292fce4ff3287267324b\"\n     onclick=\"log_download('anonymous-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047785286&amp;doi=10.1134%2fS1990750818020117&amp;partnerID=40&amp;md5=8e974b0f5e74292fce4ff3287267324b', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Isolation of Extracellular Microvesicles from Cell Culture Medium: Comparative Evaluation of Methods [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1134/S1990750818020117\"\n     onclick=\"log_download('anonymous-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018', 'http://doi.org/10.1134/S1990750818020117', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/anonymous-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('anonymous-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\"></pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by “horizontal” exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional EV features are usually studied in vitro. Several methods of EV isolation from cell culture medium are currently used; however, selection of a particular method may have a significant impact on obtained results. The choice of the optimal method is usually determined by the amount of starting biomaterial and the aims of the research. We have performed a comparative analysis of four different methods of EV isolation from cell culture medium: differential ultracentrifugation, ultracentrifugation with 30% sucrose/D 2 O “cushion,” precipitation with plant proteins and latex-based immunoaffinity capturing. EV isolated from several human glial cell lines by different approaches were compared in terms of the following parameters: size, concentration, EV morphology, contamination by non-vesicular particles, content of exosomal tetraspanins on the EV surface, content of total proteins, total RNA, and several glioma-associated miRNAs. The applied methods included nanoparticle tracking analysis (NTA), dynamic light scattering (DLS), cryo-electron microscopy, flow cytometry and RT-qPCR. Based on the obtained results, we have developed practical recommendations that may help researchers to make the best choice of the EV isolation method. © 2018, Pleiades Publishing, Ltd.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"vasiliev-churilov-trashkov-utekhin-evolutionoftheimmunesystemandregulatoryeffectsofantibodies-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&amp;doi=10.31116%2ftsitol.2018.02.01&amp;partnerID=40&amp;md5=4f72752ca24dd84fcf15a3c741525d12\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'vasiliev-churilov-trashkov-utekhin-evolutionoftheimmunesystemandregulatoryeffectsofantibodies-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&amp;doi=10.31116%2ftsitol.2018.02.01&amp;partnerID=40&amp;md5=4f72752ca24dd84fcf15a3c741525d12', event);\">\n    Evolution of the immune system and regulatory effects of antibodies.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Vasiliev, A.; Churilov, L.; Trashkov, A.;  and Utekhin, V.\n</span>\n\n  \n\n</span>\n\n  <i>Tsitologiya</i>, 60(2): 71-80.  2018.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&amp;doi=10.31116%2ftsitol.2018.02.01&amp;partnerID=40&amp;md5=4f72752ca24dd84fcf15a3c741525d12\"\n     onclick=\"log_download('vasiliev-churilov-trashkov-utekhin-evolutionoftheimmunesystemandregulatoryeffectsofantibodies-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&amp;doi=10.31116%2ftsitol.2018.02.01&amp;partnerID=40&amp;md5=4f72752ca24dd84fcf15a3c741525d12', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Evolution of the immune system and regulatory effects of antibodies [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.31116/tsitol.2018.02.01\"\n     onclick=\"log_download('vasiliev-churilov-trashkov-utekhin-evolutionoftheimmunesystemandregulatoryeffectsofantibodies-2018', 'http://doi.org/10.31116/tsitol.2018.02.01', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/vasiliev-churilov-trashkov-utekhin-evolutionoftheimmunesystemandregulatoryeffectsofantibodies-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('vasiliev-churilov-trashkov-utekhin-evolutionoftheimmunesystemandregulatoryeffectsofantibodies-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Vasiliev201871,\r\nauthor={Vasiliev, A.G. and Churilov, L.P. and Trashkov, A.P. and Utekhin, V.I.},\r\ntitle={Evolution of the immune system and regulatory effects of antibodies},\r\njournal={Tsitologiya},\r\nyear={2018},\r\nvolume={60},\r\nnumber={2},\r\npages={71-80},\r\ndoi={10.31116/tsitol.2018.02.01},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064638899&amp;doi=10.31116%2ftsitol.2018.02.01&amp;partnerID=40&amp;md5=4f72752ca24dd84fcf15a3c741525d12},\r\naffiliation={St. Petersburg State Pediatric Medical University, St. Petersburg, 194353, Russian Federation; St. Petersburg State University, St. Petersburg, 199106, Russian Federation; Petersburg Nuclear Physics Institute named by, B. P. Konstantinov of National Research Centre «Kurchatov Institute», Gatchina, 188300, Russian Federation},\r\nabstract={The immune system is usually regarded as a tool for defense against pathogens. The review however focuses at non-traditional aspects of immune system activity that are seldom discussed. Immunoglobulins are products of genes super-family which is a part of cell adhesion molecules genes associated with multicellularity and thus in addition to regulation of immune response antibodies may accomplish integrative regulatory effects outside immune system using the very same principles (complementarity, positive and negative feedback, etc.), that are characteristic of the nervous and endocrine systems. The review sums up general principles of the antibodies’ regulatory effects in physiologic and pathologic processes as well as mechanisms that help them penetrate intact cell membrane and travel further into the nucleus and the principles of their intracellular activity by means of repression (derepression) of key cellular structures. © 2018 Sankt Peterburg.All rights reserved.},\r\nauthor_keywords={Antinuclear antibodies;  Derepression;  Immunoglobuline regulation;  Regulatory effects of antibodies;  Repression},\r\ncorrespondence_address1={Vasiliev, A.G.; St. Petersburg State Pediatric Medical UniversityRussian Federation; email: avas7@mail.ru},\r\npublisher={Sankt Peterburg},\r\nissn={00413771},\r\ncoden={TSITA},\r\nlanguage={Russian},\r\nabbrev_source_title={Tsitologiya},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The immune system is usually regarded as a tool for defense against pathogens. The review however focuses at non-traditional aspects of immune system activity that are seldom discussed. Immunoglobulins are products of genes super-family which is a part of cell adhesion molecules genes associated with multicellularity and thus in addition to regulation of immune response antibodies may accomplish integrative regulatory effects outside immune system using the very same principles (complementarity, positive and negative feedback, etc.), that are characteristic of the nervous and endocrine systems. The review sums up general principles of the antibodies’ regulatory effects in physiologic and pathologic processes as well as mechanisms that help them penetrate intact cell membrane and travel further into the nucleus and the principles of their intracellular activity by means of repression (derepression) of key cellular structures. © 2018 Sankt Peterburg.All rights reserved.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"tsygan-andreev-peleshok-kolomentsev-yakovleva-ryabtsev-gumennaya-litvinenko-perioperativestrokeinheartvalvesurgerypathogenesisclinicalfindingsdiagnosispreventiontreatment-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&amp;doi=10.17116%2fjnevro20181184152-60&amp;partnerID=40&amp;md5=131b0d4388095a7f8bbc47747a3505af\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'tsygan-andreev-peleshok-kolomentsev-yakovleva-ryabtsev-gumennaya-litvinenko-perioperativestrokeinheartvalvesurgerypathogenesisclinicalfindingsdiagnosispreventiontreatment-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&amp;doi=10.17116%2fjnevro20181184152-60&amp;partnerID=40&amp;md5=131b0d4388095a7f8bbc47747a3505af', event);\">\n    Perioperative stroke in heart valve surgery: Pathogenesis, clinical findings, diagnosis, prevention, treatment.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Tsygan, N.; Andreev, R.; Peleshok, A.; Kolomentsev, S.; Yakovleva, V.; Ryabtsev, A.; Gumennaya, M.;  and Litvinenko, I.\n</span>\n\n  \n\n</span>\n\n  <i>Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova</i>, 118(4): 52-60.  2018.\n  <span class=\"note\">cited By 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&amp;doi=10.17116%2fjnevro20181184152-60&amp;partnerID=40&amp;md5=131b0d4388095a7f8bbc47747a3505af\"\n     onclick=\"log_download('tsygan-andreev-peleshok-kolomentsev-yakovleva-ryabtsev-gumennaya-litvinenko-perioperativestrokeinheartvalvesurgerypathogenesisclinicalfindingsdiagnosispreventiontreatment-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&amp;doi=10.17116%2fjnevro20181184152-60&amp;partnerID=40&amp;md5=131b0d4388095a7f8bbc47747a3505af', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Perioperative stroke in heart valve surgery: Pathogenesis, clinical findings, diagnosis, prevention, treatment [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.17116/jnevro20181184152-60\"\n     onclick=\"log_download('tsygan-andreev-peleshok-kolomentsev-yakovleva-ryabtsev-gumennaya-litvinenko-perioperativestrokeinheartvalvesurgerypathogenesisclinicalfindingsdiagnosispreventiontreatment-2018', 'http://doi.org/10.17116/jnevro20181184152-60', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/tsygan-andreev-peleshok-kolomentsev-yakovleva-ryabtsev-gumennaya-litvinenko-perioperativestrokeinheartvalvesurgerypathogenesisclinicalfindingsdiagnosispreventiontreatment-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('tsygan-andreev-peleshok-kolomentsev-yakovleva-ryabtsev-gumennaya-litvinenko-perioperativestrokeinheartvalvesurgerypathogenesisclinicalfindingsdiagnosispreventiontreatment-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Tsygan201852,\r\nauthor={Tsygan, N.V. and Andreev, R.V. and Peleshok, A.S. and Kolomentsev, S.V. and Yakovleva, V.A. and Ryabtsev, A.V. and Gumennaya, M.A. and Litvinenko, I.V.},\r\ntitle={Perioperative stroke in heart valve surgery: Pathogenesis, clinical findings, diagnosis, prevention, treatment},\r\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\r\nyear={2018},\r\nvolume={118},\r\nnumber={4},\r\npages={52-60},\r\ndoi={10.17116/jnevro20181184152-60},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85048052159&amp;doi=10.17116%2fjnevro20181184152-60&amp;partnerID=40&amp;md5=131b0d4388095a7f8bbc47747a3505af},\r\naffiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russian Federation; Dzhanelidze St. Petersburg Research Institute of Emergency Medicine, St. Petersburg, Russian Federation; Sechenov Institute of Evolutionary Biochemistry and Physiology of Russian Academy of Science, St. Petersburg, Russian Federation},\r\nabstract={Objective. To study risk factors, characteristics of clinical symptoms and diagnosis, and possibilities of prevention of perioperative stroke and other clinical types of cerebral dysfunction in main types of heart valve surgery. Material and methods. The study included 83 patients, aged 63 (54; 70) years, undergoing heart valve surgery with cardiopulmonary bypass. Results. Postoperative cerebral dysfunction was diagnosed in 37.3% of cases, including perioperative stroke in 3.6% of cases. In cases of aortic stenosis, the frequency of perioperative stroke was 9.5%. The cardioembolic subtype of perioperative ischemic stroke in cardiac valve surgery was most likely. The risk factors of the symptomatic delirium of the early postoperative period are: age over 75 years, preoperative frontal dysfunction, duration of artificial respiratory care more than 20 hours after the surgery. Conclusion. The results suggest the efficacy of preventive use of cytoflavin for reducing the frequency and severity of perioperative stroke and symptomatic delirium of the early postoperative period in heart valve surgery with cardiopulmonary bypass. © 2018, Media Sphera Publishing Group. All Rights Reserved.},\r\nauthor_keywords={Cardiopulmonary bypass;  Cytoflavin;  Delayed cognitive impairment;  Heart valve surgery;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},\r\npublisher={Media Sphera Publishing Group},\r\nissn={19977298},\r\npubmed_id={29863693},\r\nlanguage={Russian},\r\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objective. To study risk factors, characteristics of clinical symptoms and diagnosis, and possibilities of prevention of perioperative stroke and other clinical types of cerebral dysfunction in main types of heart valve surgery. Material and methods. The study included 83 patients, aged 63 (54; 70) years, undergoing heart valve surgery with cardiopulmonary bypass. Results. Postoperative cerebral dysfunction was diagnosed in 37.3% of cases, including perioperative stroke in 3.6% of cases. In cases of aortic stenosis, the frequency of perioperative stroke was 9.5%. The cardioembolic subtype of perioperative ischemic stroke in cardiac valve surgery was most likely. The risk factors of the symptomatic delirium of the early postoperative period are: age over 75 years, preoperative frontal dysfunction, duration of artificial respiratory care more than 20 hours after the surgery. Conclusion. The results suggest the efficacy of preventive use of cytoflavin for reducing the frequency and severity of perioperative stroke and symptomatic delirium of the early postoperative period in heart valve surgery with cardiopulmonary bypass. © 2018, Media Sphera Publishing Group. All Rights Reserved.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"shtam-samsonov-volnitskiy-kamyshinsky-verlov-kniazeva-korobkina-orehov-etal-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&amp;doi=10.18097%2fPBMC20186401023&amp;partnerID=40&amp;md5=b472419d6f68dab8bffc8f53af96f345\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'shtam-samsonov-volnitskiy-kamyshinsky-verlov-kniazeva-korobkina-orehov-etal-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&amp;doi=10.18097%2fPBMC20186401023&amp;partnerID=40&amp;md5=b472419d6f68dab8bffc8f53af96f345', event);\">\n    Isolation of extracellular micro-vesicles from cell culture medium: Comparative evaluation of methods.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Shtam, T.; Samsonov, R.; Volnitskiy, A.; Kamyshinsky, R.; Verlov, N.; Kniazeva, M.; Korobkina, E.; Orehov, A.; Vasiliev, A.; Konevega, A.;  and Malek, A.\n</span>\n\n  \n\n</span>\n\n  <i>Biomeditsinskaya Khimiya</i>, 64(1): 23-30.  2018.\n  <span class=\"note\">cited By 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&amp;doi=10.18097%2fPBMC20186401023&amp;partnerID=40&amp;md5=b472419d6f68dab8bffc8f53af96f345\"\n     onclick=\"log_download('shtam-samsonov-volnitskiy-kamyshinsky-verlov-kniazeva-korobkina-orehov-etal-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&amp;doi=10.18097%2fPBMC20186401023&amp;partnerID=40&amp;md5=b472419d6f68dab8bffc8f53af96f345', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Isolation of extracellular micro-vesicles from cell culture medium: Comparative evaluation of methods [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.18097/PBMC20186401023\"\n     onclick=\"log_download('shtam-samsonov-volnitskiy-kamyshinsky-verlov-kniazeva-korobkina-orehov-etal-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018', 'http://doi.org/10.18097/PBMC20186401023', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/shtam-samsonov-volnitskiy-kamyshinsky-verlov-kniazeva-korobkina-orehov-etal-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('shtam-samsonov-volnitskiy-kamyshinsky-verlov-kniazeva-korobkina-orehov-etal-isolationofextracellularmicrovesiclesfromcellculturemediumcomparativeevaluationofmethods-2018')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Shtam201823,\r\nauthor={Shtam, T.A. and Samsonov, R.A. and Volnitskiy, A.V. and Kamyshinsky, R.A. and Verlov, N.A. and Kniazeva, M.S. and Korobkina, E.A. and Orehov, A.S. and Vasiliev, A.L. and Konevega, A.L. and Malek, A.V.},\r\ntitle={Isolation of extracellular micro-vesicles from cell culture medium: Comparative evaluation of methods},\r\njournal={Biomeditsinskaya Khimiya},\r\nyear={2018},\r\nvolume={64},\r\nnumber={1},\r\npages={23-30},\r\ndoi={10.18097/PBMC20186401023},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043459724&amp;doi=10.18097%2fPBMC20186401023&amp;partnerID=40&amp;md5=b472419d6f68dab8bffc8f53af96f345},\r\naffiliation={Petersburg Nuclear Physics Institute of National Research Centre &#x27;Kurchatov Institute&#x27;, Saint-Petersburg, Gatchina, 188300, Russian Federation; &#x27;Oncosystem&#x27; Ltd., Skolkovo, 143026, Russian Federation; N.N.Petrov National Medical Research Center of Oncology, Saint-Petersburg, 197758, Russian Federation; National Research Center &#x27;Kurchatov Institute&#x27;, Moscow, 123182, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, 195251, Russian Federation},\r\nabstract={Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by &quot;horizontal&quot; exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional features of the EV is being commonly studies in in vitro condition. Several methods of EV isolation from cell culture medium are established, however selection of method might influence on obtained results. The choice of the optimal method depends usually from the amount of medium and the aims of the research while is still challenging issue. We performed a comparative analysis of four different methods of EV isolation from cell culture medium: differential ultracentrifugation, ultracentrifugation with a 30% sucrose/D2O &quot;cushion&quot;, precipitation with plant proteins and immune-affinity capturing. EV isolated by different approaches were compared in terms of following parameters: size, concentration, morphology of EV, contamination by non-vesicular particles, content of exosomal tetraspanins on the EV surface, content of total proteins, RNA, and several glioma-associated miRNAs. Applied methods included nano-patricle tracking analysis (NTA), dynamic light scattering (DLS), cryo-electron microscopy, flow cytometry and RT-qPCR. On the base of obtained results, we developed practical recommendations that may help researchers to make a best choice of EV isolation method. © 2018 Russian Academy of Medical Sciences. All rights reserved.},\r\nauthor_keywords={Exsosomes;  Extracellular vesicles;  Immunoprecipitation;  Lectines;  Methods of isolation;  Ultracentrifugation},\r\ncorrespondence_address1={Shtam, T.A.; Petersburg Nuclear Physics Institute of National Research Centre &#x27;Kurchatov Institute&#x27;Russian Federation; email: tatyana_shtam@mail.ru},\r\npublisher={Russian Academy of Medical Sciences},\r\nissn={23106905},\r\npubmed_id={29460831},\r\nlanguage={Russian},\r\nabbrev_source_title={Biomeditsinskaya Khim.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Extracellular vesicles (EV) are secreted by cells of multicellular organisms. EV mediate specific mode of intercellular communication by \"horizontal\" exchange of substances and information. This phenomenon seems to have an essential biological significance and became a subject of intensive research. Biogenesis, structural and functional features of the EV is being commonly studies in in vitro condition. Several methods of EV isolation from cell culture medium are established, however selection of method might influence on obtained results. The choice of the optimal method depends usually from the amount of medium and the aims of the research while is still challenging issue. We performed a comparative analysis of four different methods of EV isolation from cell culture medium: differential ultracentrifugation, ultracentrifugation with a 30% sucrose/D2O \"cushion\", precipitation with plant proteins and immune-affinity capturing. EV isolated by different approaches were compared in terms of following parameters: size, concentration, morphology of EV, contamination by non-vesicular particles, content of exosomal tetraspanins on the EV surface, content of total proteins, RNA, and several glioma-associated miRNAs. Applied methods included nano-patricle tracking analysis (NTA), dynamic light scattering (DLS), cryo-electron microscopy, flow cytometry and RT-qPCR. On the base of obtained results, we developed practical recommendations that may help researchers to make a best choice of EV isolation method. © 2018 Russian Academy of Medical Sciences. All rights reserved.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2017\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2017')\"\n      onkeypress=\"toggleGroup('group_2017')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2017</span>\n      <span class=\"bibbase_group_count\">\n        \n        (7)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"shtam-samsonov-kamyshinsky-pantina-verlov-vasiliev-konevega-malek-exosomessomeapproachestocancerdiagnosisandtherapy-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&amp;doi=10.1063%2f1.5001645&amp;partnerID=40&amp;md5=d908b66243d4ade3a27c45bad492f886\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'shtam-samsonov-kamyshinsky-pantina-verlov-vasiliev-konevega-malek-exosomessomeapproachestocancerdiagnosisandtherapy-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&amp;doi=10.1063%2f1.5001645&amp;partnerID=40&amp;md5=d908b66243d4ade3a27c45bad492f886', event);\">\n    Exosomes: Some approaches to cancer diagnosis and therapy.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Shtam, T.; Samsonov, R.; Kamyshinsky, R.; Pantina, R.; Verlov, N.; Vasiliev, A.; Konevega, A.;  and Malek, A.\n</span>\n\n  \n\n</span>\n\n   2017.<!-- NOTE FROM BIBBASE: This entry has an invalid bibtex entry type: conference. Therefore, we don't know how to render it properly. Please consider fixing this. -->\n  <span class=\"note\">cited By 5; Conference of International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 ; Conference Date: 23 May 2017 Through 26 May 2017; Conference Code:133914</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&amp;doi=10.1063%2f1.5001645&amp;partnerID=40&amp;md5=d908b66243d4ade3a27c45bad492f886\"\n     onclick=\"log_download('shtam-samsonov-kamyshinsky-pantina-verlov-vasiliev-konevega-malek-exosomessomeapproachestocancerdiagnosisandtherapy-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&amp;doi=10.1063%2f1.5001645&amp;partnerID=40&amp;md5=d908b66243d4ade3a27c45bad492f886', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Exosomes: Some approaches to cancer diagnosis and therapy [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1063/1.5001645\"\n     onclick=\"log_download('shtam-samsonov-kamyshinsky-pantina-verlov-vasiliev-konevega-malek-exosomessomeapproachestocancerdiagnosisandtherapy-2017', 'http://doi.org/10.1063/1.5001645', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/shtam-samsonov-kamyshinsky-pantina-verlov-vasiliev-konevega-malek-exosomessomeapproachestocancerdiagnosisandtherapy-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>1 download</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('shtam-samsonov-kamyshinsky-pantina-verlov-vasiliev-konevega-malek-exosomessomeapproachestocancerdiagnosisandtherapy-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@CONFERENCE{Shtam2017,\r\nauthor={Shtam, T. and Samsonov, R. and Kamyshinsky, R. and Pantina, R. and Verlov, N. and Vasiliev, A. and Konevega, A.L. and Malek, A.V.},\r\ntitle={Exosomes: Some approaches to cancer diagnosis and therapy},\r\njournal={AIP Conference Proceedings},\r\nyear={2017},\r\nvolume={1882},\r\ndoi={10.1063/1.5001645},\r\nart_number={020066},\r\nnote={cited By 5; Conference of International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017 ; Conference Date: 23 May 2017 Through 26 May 2017;  Conference Code:133914},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041662414&amp;doi=10.1063%2f1.5001645&amp;partnerID=40&amp;md5=d908b66243d4ade3a27c45bad492f886},\r\naffiliation={Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov Institute, Gatchina, Russian Federation; Petrov Institute of Oncology, Saint-Petersburg, Russian Federation; Ltd. Oncosystem, Skolkovo, Russian Federation; Peter the Great Saint-Petersburg Polytechnic University, St. Petersburg, Russian Federation; National Research Center, Kurchatov Institute, Moscow, Russian Federation},\r\nabstract={Exosomes are membrane-bound, intercellular communication shuttle vesicles that are defined by their endocytic origin and size range of 30-120 nm. Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive tool in identifying cancer biomarkers and exploiting exosomes for therapy. In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. Here, we present the possibility of carrying the exogenous p53 protein by exosomes in vitro. © 2017 Author(s).},\r\ncorrespondence_address1={Shtam, T.; Petersburg Nuclear Physics Institute of National Research Centre, Kurchatov InstituteRussian Federation; email: tatyana_shtam@mail.ru},\r\neditor={Gutmanas E.Y., Naimark O.B., Sharkeev Y.P.},\r\nsponsors={Institute of Continuous Media Mechanics of UrB RAS; Institute of Strength Physics and Materials Science of SB RAS; National Research Tomsk Polytechnic University; National Research Tomsk State University; Tomsk Research Institute of Oncology},\r\npublisher={American Institute of Physics Inc.},\r\nissn={0094243X},\r\nisbn={9780735415621},\r\nlanguage={English},\r\nabbrev_source_title={AIP Conf. Proc.},\r\ndocument_type={Conference Paper},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Exosomes are membrane-bound, intercellular communication shuttle vesicles that are defined by their endocytic origin and size range of 30-120 nm. Secreted by nearly all mammalian cell types and present in bodily fluids, exosomes confer messages between cells, by transporting functionally relevant proteins, nucleic acids, and lipids. The capability of tumor exosomes to house tumorigenic information and induce cellular responses that promote disease pathogenesis make tumor exosomes an attractive tool in identifying cancer biomarkers and exploiting exosomes for therapy. In this paper, we sum up our previous findings to utilize exosomes as biomarkers for early detection, diagnosis and therapy selection of prostate and thyroid cancer and present our results on exosomes in colon cancer. Some of plasma exosomal miRNAs showed their potential as diagnostic markers for colon cancer. All together, the data suggested the potentials of circulating exosomal miRNAs as liquid biopsy markers for cancer. Here we also present the possibilities of delivering therapeutic molecules by exosomes. Previously, we had demonstrated the potential of exosome-mediated siRNA delivery. Here, we present the possibility of carrying the exogenous p53 protein by exosomes in vitro. © 2017 Author(s).\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"stupin-koniakhin-verlov-dubina-adaptivefilteringtoenhancenoiseimmunityofimpedanceandadmittancespectroscopycomparisonwithfouriertransformation-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&amp;doi=10.1103%2fPhysRevApplied.7.054024&amp;partnerID=40&amp;md5=58dc07671359acd5a9cf7852835d8eba\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'stupin-koniakhin-verlov-dubina-adaptivefilteringtoenhancenoiseimmunityofimpedanceandadmittancespectroscopycomparisonwithfouriertransformation-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&amp;doi=10.1103%2fPhysRevApplied.7.054024&amp;partnerID=40&amp;md5=58dc07671359acd5a9cf7852835d8eba', event);\">\n    Adaptive Filtering to Enhance Noise Immunity of Impedance and Admittance Spectroscopy: Comparison with Fourier Transformation.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Stupin, D.; Koniakhin, S.; Verlov, N.;  and Dubina, M.\n</span>\n\n  \n\n</span>\n\n  <i>Physical Review Applied</i>, 7(5).  2017.\n  <span class=\"note\">cited By 8</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&amp;doi=10.1103%2fPhysRevApplied.7.054024&amp;partnerID=40&amp;md5=58dc07671359acd5a9cf7852835d8eba\"\n     onclick=\"log_download('stupin-koniakhin-verlov-dubina-adaptivefilteringtoenhancenoiseimmunityofimpedanceandadmittancespectroscopycomparisonwithfouriertransformation-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&amp;doi=10.1103%2fPhysRevApplied.7.054024&amp;partnerID=40&amp;md5=58dc07671359acd5a9cf7852835d8eba', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Adaptive Filtering to Enhance Noise Immunity of Impedance and Admittance Spectroscopy: Comparison with Fourier Transformation [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1103/PhysRevApplied.7.054024\"\n     onclick=\"log_download('stupin-koniakhin-verlov-dubina-adaptivefilteringtoenhancenoiseimmunityofimpedanceandadmittancespectroscopycomparisonwithfouriertransformation-2017', 'http://doi.org/10.1103/PhysRevApplied.7.054024', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/stupin-koniakhin-verlov-dubina-adaptivefilteringtoenhancenoiseimmunityofimpedanceandadmittancespectroscopycomparisonwithfouriertransformation-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('stupin-koniakhin-verlov-dubina-adaptivefilteringtoenhancenoiseimmunityofimpedanceandadmittancespectroscopycomparisonwithfouriertransformation-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Stupin2017,\r\nauthor={Stupin, D.D. and Koniakhin, S.V. and Verlov, N.A. and Dubina, M.V.},\r\ntitle={Adaptive Filtering to Enhance Noise Immunity of Impedance and Admittance Spectroscopy: Comparison with Fourier Transformation},\r\njournal={Physical Review Applied},\r\nyear={2017},\r\nvolume={7},\r\nnumber={5},\r\ndoi={10.1103/PhysRevApplied.7.054024},\r\nart_number={054024},\r\nnote={cited By 8},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020026659&amp;doi=10.1103%2fPhysRevApplied.7.054024&amp;partnerID=40&amp;md5=58dc07671359acd5a9cf7852835d8eba},\r\naffiliation={St. Petersburg Academic University, Khlopina 8/3, St. Petersburg, 194021, Russian Federation; Petersburg Nuclear Physics Institute NRC Kurchatov Institute, Gatchina, St. Petersburg, 188300, Russian Federation; Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya str. 29, St. Petersburg, 195251, Russian Federation},\r\nabstract={The time-domain technique for impedance spectroscopy consists of computing the excitation voltage and current response Fourier images by fast or discrete Fourier transformation and calculating their relation. Here we propose an alternative method for excitation voltage and current response processing for deriving a system impedance spectrum based on a fast and flexible adaptive filtering method. We show the equivalence between the problem of adaptive filter learning and deriving the system impedance spectrum. To be specific, we express the impedance via the adaptive filter weight coefficients. The noise-canceling property of adaptive filtering is also justified. Using the RLC circuit as a model system, we experimentally show that adaptive filtering yields correct admittance spectra and elements ratings in the high-noise conditions when the Fourier-transform technique fails. Providing the additional sensitivity of impedance spectroscopy, adaptive filtering can be applied to otherwise impossible-to-interpret time-domain impedance data. The advantages of adaptive filtering are justified with practical living-cell impedance measurements. © 2017 American Physical Society.},\r\npublisher={American Physical Society},\r\nissn={23317019},\r\nlanguage={English},\r\nabbrev_source_title={Phys. Rev. Appl.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The time-domain technique for impedance spectroscopy consists of computing the excitation voltage and current response Fourier images by fast or discrete Fourier transformation and calculating their relation. Here we propose an alternative method for excitation voltage and current response processing for deriving a system impedance spectrum based on a fast and flexible adaptive filtering method. We show the equivalence between the problem of adaptive filter learning and deriving the system impedance spectrum. To be specific, we express the impedance via the adaptive filter weight coefficients. The noise-canceling property of adaptive filtering is also justified. Using the RLC circuit as a model system, we experimentally show that adaptive filtering yields correct admittance spectra and elements ratings in the high-noise conditions when the Fourier-transform technique fails. Providing the additional sensitivity of impedance spectroscopy, adaptive filtering can be applied to otherwise impossible-to-interpret time-domain impedance data. The advantages of adaptive filtering are justified with practical living-cell impedance measurements. © 2017 American Physical Society.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithaprolongedmodelofthemetabolicsyndromeinducedbyahighcarbohydrateandhighfatdiet-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&amp;doi=10.1134%2fS2079057017020035&amp;partnerID=40&amp;md5=d87870b22f7bf0c1ea94f6adc3d657af\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithaprolongedmodelofthemetabolicsyndromeinducedbyahighcarbohydrateandhighfatdiet-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&amp;doi=10.1134%2fS2079057017020035&amp;partnerID=40&amp;md5=d87870b22f7bf0c1ea94f6adc3d657af', event);\">\n    Metabolic and hormonal indices in rats with a prolonged model of the metabolic syndrome induced by a high-carbohydrate and high-fat diet.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Derkach, K.; Bondareva, V.; Trashkov, A.; Chistyakova, O.; Verlov, N.;  and Shpakov, A.\n</span>\n\n  \n\n</span>\n\n  <i>Advances in Gerontology</i>, 7(2): 130-136.  2017.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&amp;doi=10.1134%2fS2079057017020035&amp;partnerID=40&amp;md5=d87870b22f7bf0c1ea94f6adc3d657af\"\n     onclick=\"log_download('derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithaprolongedmodelofthemetabolicsyndromeinducedbyahighcarbohydrateandhighfatdiet-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&amp;doi=10.1134%2fS2079057017020035&amp;partnerID=40&amp;md5=d87870b22f7bf0c1ea94f6adc3d657af', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Metabolic and hormonal indices in rats with a prolonged model of the metabolic syndrome induced by a high-carbohydrate and high-fat diet [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1134/S2079057017020035\"\n     onclick=\"log_download('derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithaprolongedmodelofthemetabolicsyndromeinducedbyahighcarbohydrateandhighfatdiet-2017', 'http://doi.org/10.1134/S2079057017020035', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithaprolongedmodelofthemetabolicsyndromeinducedbyahighcarbohydrateandhighfatdiet-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithaprolongedmodelofthemetabolicsyndromeinducedbyahighcarbohydrateandhighfatdiet-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Derkach2017130,\r\nauthor={Derkach, K.V. and Bondareva, V.M. and Trashkov, A.P. and Chistyakova, O.V. and Verlov, N.A. and Shpakov, A.O.},\r\ntitle={Metabolic and hormonal indices in rats with a prolonged model of the metabolic syndrome induced by a high-carbohydrate and high-fat diet},\r\njournal={Advances in Gerontology},\r\nyear={2017},\r\nvolume={7},\r\nnumber={2},\r\npages={130-136},\r\ndoi={10.1134/S2079057017020035},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025149722&amp;doi=10.1134%2fS2079057017020035&amp;partnerID=40&amp;md5=d87870b22f7bf0c1ea94f6adc3d657af},\r\naffiliation={Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russian Federation},\r\nabstract={To develop approaches for the prevention and treatment of the metabolic syndrome (MS), a pathological state widespread in the modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of the MS are required. One of these models is induced by the consumption of a combined high-carbohydrate and high-fat (HC/HF) diet. However, the character, temporal dynamics and severity of the metabolic abnormalities in MS induced by the HC/HF diet are still poorly understood. The aim of this work was to characterize the metabolic changes in Wistar rats with the MS induced by a 10- and 15-week HC/HF diet which included the consumption of a 30% sucrose solution (instead of drinking water) and food rich in saturated fats. The rats which received the HC/HF diet for 15 weeks had a number of features characteristic of the MS such as increased body mass and a specific content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system, hyperhomocysteinemia, a reduced level of nitric oxide and increased concentration of endothelin-1. In the rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of a 10-week duration of the HC/HF diet for the MS induction. Thus, the model of the MS induced by a 15-week HC/HF diet has the characteristic features which allow for extrapolation of the obtained data to similar pathologic changes in humans, and can be used in the study of the etiology and pathogenesis of the MS and in the search for effective ways of MS prevention and treatment. © 2017, Pleiades Publishing, Ltd.},\r\nauthor_keywords={biomodelling;  dyslipidemia;  endothelial dysfunction;  glucose tolerance;  high-carbohydrate and high-fat diet;  insulin resistance;  metabolic syndrome},\r\ncorrespondence_address1={Derkach, K.V.; Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of SciencesRussian Federation; email: derkatch_k@list.ru},\r\npublisher={Maik Nauka Publishing / Springer SBM},\r\nissn={20790570},\r\nlanguage={English},\r\nabbrev_source_title={Adv. Gerontol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  To develop approaches for the prevention and treatment of the metabolic syndrome (MS), a pathological state widespread in the modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of the MS are required. One of these models is induced by the consumption of a combined high-carbohydrate and high-fat (HC/HF) diet. However, the character, temporal dynamics and severity of the metabolic abnormalities in MS induced by the HC/HF diet are still poorly understood. The aim of this work was to characterize the metabolic changes in Wistar rats with the MS induced by a 10- and 15-week HC/HF diet which included the consumption of a 30% sucrose solution (instead of drinking water) and food rich in saturated fats. The rats which received the HC/HF diet for 15 weeks had a number of features characteristic of the MS such as increased body mass and a specific content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system, hyperhomocysteinemia, a reduced level of nitric oxide and increased concentration of endothelin-1. In the rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of a 10-week duration of the HC/HF diet for the MS induction. Thus, the model of the MS induced by a 15-week HC/HF diet has the characteristic features which allow for extrapolation of the obtained data to similar pathologic changes in humans, and can be used in the study of the etiology and pathogenesis of the MS and in the search for effective ways of MS prevention and treatment. © 2017, Pleiades Publishing, Ltd.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"anonymous-metforminpreventshormonalandmetabolicdisturbancesand12dimethylhydrazineinducedcoloncarcinogenesisinnondiabeticrats-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131496&amp;doi=10.20892%2fj.issn.2095-3941.2016.0088&amp;partnerID=40&amp;md5=8951bfc8e9f56ba43897dfebdf580413\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'anonymous-metforminpreventshormonalandmetabolicdisturbancesand12dimethylhydrazineinducedcoloncarcinogenesisinnondiabeticrats-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131496&amp;doi=10.20892%2fj.issn.2095-3941.2016.0088&amp;partnerID=40&amp;md5=8951bfc8e9f56ba43897dfebdf580413', event);\">\n    Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  \n</span>\n\n  \n\n</span>\n\n  <i>Cancer Biology and Medicine</i>, 14(1): 100-107.  2017.\n  <span class=\"note\">cited By 4</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131496&amp;doi=10.20892%2fj.issn.2095-3941.2016.0088&amp;partnerID=40&amp;md5=8951bfc8e9f56ba43897dfebdf580413\"\n     onclick=\"log_download('anonymous-metforminpreventshormonalandmetabolicdisturbancesand12dimethylhydrazineinducedcoloncarcinogenesisinnondiabeticrats-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017131496&amp;doi=10.20892%2fj.issn.2095-3941.2016.0088&amp;partnerID=40&amp;md5=8951bfc8e9f56ba43897dfebdf580413', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.20892/j.issn.2095-3941.2016.0088\"\n     onclick=\"log_download('anonymous-metforminpreventshormonalandmetabolicdisturbancesand12dimethylhydrazineinducedcoloncarcinogenesisinnondiabeticrats-2017', 'http://doi.org/10.20892/j.issn.2095-3941.2016.0088', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/anonymous-metforminpreventshormonalandmetabolicdisturbancesand12dimethylhydrazineinducedcoloncarcinogenesisinnondiabeticrats-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('anonymous-metforminpreventshormonalandmetabolicdisturbancesand12dimethylhydrazineinducedcoloncarcinogenesisinnondiabeticrats-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\"></pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulinlike growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer. Copyright © 2017 by Cancer Biology & Medicine.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithprolongedmodelofmetabolicsyndromeinducedbyhighcarbohydrateandhighfatdiet-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&amp;partnerID=40&amp;md5=b0a1e874778d13e5a015e02345df4028\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithprolongedmodelofmetabolicsyndromeinducedbyhighcarbohydrateandhighfatdiet-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&amp;partnerID=40&amp;md5=b0a1e874778d13e5a015e02345df4028', event);\">\n    Metabolic and hormonal indices in rats with prolonged model of metabolic syndrome induced by high-carbohydrate and high-fat diet.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Derkach, K.; Bondareva, V.; Trashkov, A.; Chistyakova, O.; Verlov, N.;  and Shpakov, A.\n</span>\n\n  \n\n</span>\n\n  <i>Advances in gerontology = Uspekhi gerontologii</i>, 30(1): 31-38.  2017.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&amp;partnerID=40&amp;md5=b0a1e874778d13e5a015e02345df4028\"\n     onclick=\"log_download('derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithprolongedmodelofmetabolicsyndromeinducedbyhighcarbohydrateandhighfatdiet-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&amp;partnerID=40&amp;md5=b0a1e874778d13e5a015e02345df4028', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Metabolic and hormonal indices in rats with prolonged model of metabolic syndrome induced by high-carbohydrate and high-fat diet [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithprolongedmodelofmetabolicsyndromeinducedbyhighcarbohydrateandhighfatdiet-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('derkach-bondareva-trashkov-chistyakova-verlov-shpakov-metabolicandhormonalindicesinratswithprolongedmodelofmetabolicsyndromeinducedbyhighcarbohydrateandhighfatdiet-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Derkach201731,\r\nauthor={Derkach, K.V. and Bondareva, V.M. and Trashkov, A.P. and Chistyakova, O.V. and Verlov, N.A. and Shpakov, A.O.},\r\ntitle={Metabolic and hormonal indices in rats with prolonged model of metabolic syndrome induced by high-carbohydrate and high-fat diet},\r\njournal={Advances in gerontology = Uspekhi gerontologii},\r\nyear={2017},\r\nvolume={30},\r\nnumber={1},\r\npages={31-38},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050211539&amp;partnerID=40&amp;md5=b0a1e874778d13e5a015e02345df4028},\r\naffiliation={I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, RAS, Saint-Petersburg, 194223, Russian Federation; derkatch_k@list.ru},\r\nabstract={To develop the approaches for the prevention and treatment of metabolic syndrome (MS), a pathological state widespread in modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of MS are required. One of these models is induced by the consumption of combined high-carbohydrate and high-fat (HC/HF) diet consisting of excess amount of easily digestible carbohydrates and saturated fats. At the same time, the character, temporal dynamics and severity of metabolic abnormalities in MS induced by HC/HF diet are still poorly understood. The aim of work was the characterization of metabolic changes in Wistar rats with MS induced by 10- and 15-week HC/HF diet that includes the consumption of 30% sucrose solution (instead of drinking water) and food rich in saturated fats. Rats that received HC/HF diet for 15 weeks had a number of features characteristic of MS, such as increased body weight and content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system (hyperhomocysteinemia, the reduced level of vasodilator nitric oxide, the increased concentration of vasoconstrictor endothelin 1). In rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of 10-week duration of HC/HF diet for MS induction. Thus, the model of MS induced by 15-week HC/HF diet has the characteristic features that allow for extrapolation of the obtained data to similar pathologic changes in human, and can be used to study the etiology and pathogenesis of MS and the search of effective ways of MS prevention and treatment.\r\nДля разработки методов профилактики и лечения метаболического синдрома (МС), необходимы адекватные его модели на животных. Одна из таких моделей индуцируется потреблением комбинированного высокоуглеводного и высокожирового (ВУ/ВЖ) рациона. Однако характер, динамика во времени и степень тяжести метаболических нарушений при индукции МС с помощью ВУ/ВЖ диеты остаются мало изученными. Цель работы состояла в характеристике метаболических изменений в организме крыс линии Wistar с МС, вызванным 10- и 15-недельной ВУ/ВЖ диетой, которая включала потребление 30 % раствора сахарозы (вместо питьевой воды) и пищи, обогащенной насыщенными жирами. У крыс, получавших ВУ/ВЖ диету в течение 15 нед, отмечали признаки, характерные для МС, — повышение массы тела и удельного содержания абдоминального жира, гипергликемию, гиперинсулинемию, нарушенную толерантность к глюкозе, инсулиновую резистентность, дислипидемию, а также — маркеры нарушений функции сердечно-сосудистой системы — гипергомоцистеинемию, снижение уровня оксида азота и повышение концентрации эндотелина-1. У крыс, находящихся на диете в течение 10 нед, метаболические нарушения были выражены намного слабее, что указывает на недостаточность данной продолжительности ВУ/ВЖ диеты для индукции МС. Таким образом, модель МС, вызываемая 15-недельной ВУ/ВЖ диетой, имеет характерные признаки, позволяющие проводить экстраполяцию полученных данных на сходные патологические изменения у человека, и может быть использована для изучения этиологии и патогенеза МС и поиска эффективных путей его профилактики и лечения.},\r\nauthor_keywords={biomodeling;  dyslipidemia;  endothelial dysfunction;  glucose tolerance;  high-carbohydrate and high-fat diet;  insulin resistance;  metabolic syndrome},\r\nissn={15619125},\r\npubmed_id={28557387},\r\nlanguage={Russian},\r\nabbrev_source_title={Adv Gerontol},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  To develop the approaches for the prevention and treatment of metabolic syndrome (MS), a pathological state widespread in modern population, that involves a complex of metabolic and functional disorders, appropriate animal models of MS are required. One of these models is induced by the consumption of combined high-carbohydrate and high-fat (HC/HF) diet consisting of excess amount of easily digestible carbohydrates and saturated fats. At the same time, the character, temporal dynamics and severity of metabolic abnormalities in MS induced by HC/HF diet are still poorly understood. The aim of work was the characterization of metabolic changes in Wistar rats with MS induced by 10- and 15-week HC/HF diet that includes the consumption of 30% sucrose solution (instead of drinking water) and food rich in saturated fats. Rats that received HC/HF diet for 15 weeks had a number of features characteristic of MS, such as increased body weight and content of abdominal fat, hyperglycemia, hyperinsulinaemia, impaired glucose tolerance, insulin resistance, dyslipidemia, as well as the markers of impaired function of the cardiovascular system (hyperhomocysteinemia, the reduced level of vasodilator nitric oxide, the increased concentration of vasoconstrictor endothelin 1). In rats, which were on the diet for 10 weeks, the metabolic abnormalities were less pronounced, indicating an insufficiency of 10-week duration of HC/HF diet for MS induction. Thus, the model of MS induced by 15-week HC/HF diet has the characteristic features that allow for extrapolation of the obtained data to similar pathologic changes in human, and can be used to study the etiology and pathogenesis of MS and the search of effective ways of MS prevention and treatment. Для разработки методов профилактики и лечения метаболического синдрома (МС), необходимы адекватные его модели на животных. Одна из таких моделей индуцируется потреблением комбинированного высокоуглеводного и высокожирового (ВУ/ВЖ) рациона. Однако характер, динамика во времени и степень тяжести метаболических нарушений при индукции МС с помощью ВУ/ВЖ диеты остаются мало изученными. Цель работы состояла в характеристике метаболических изменений в организме крыс линии Wistar с МС, вызванным 10- и 15-недельной ВУ/ВЖ диетой, которая включала потребление 30 % раствора сахарозы (вместо питьевой воды) и пищи, обогащенной насыщенными жирами. У крыс, получавших ВУ/ВЖ диету в течение 15 нед, отмечали признаки, характерные для МС, — повышение массы тела и удельного содержания абдоминального жира, гипергликемию, гиперинсулинемию, нарушенную толерантность к глюкозе, инсулиновую резистентность, дислипидемию, а также — маркеры нарушений функции сердечно-сосудистой системы — гипергомоцистеинемию, снижение уровня оксида азота и повышение концентрации эндотелина-1. У крыс, находящихся на диете в течение 10 нед, метаболические нарушения были выражены намного слабее, что указывает на недостаточность данной продолжительности ВУ/ВЖ диеты для индукции МС. Таким образом, модель МС, вызываемая 15-недельной ВУ/ВЖ диетой, имеет характерные признаки, позволяющие проводить экстраполяцию полученных данных на сходные патологические изменения у человека, и может быть использована для изучения этиологии и патогенеза МС и поиска эффективных путей его профилактики и лечения.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"yanishevsky-tsygan-golokhvastov-andreev-litvinenko-karpova-yakovleva-modernstrategiesofprotectionofhypoxicischemicbraindamage-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&amp;doi=10.17116%2fjnevro201711712278-86&amp;partnerID=40&amp;md5=76c5f916d4b4f14fdb4d0bd05109ba70\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'yanishevsky-tsygan-golokhvastov-andreev-litvinenko-karpova-yakovleva-modernstrategiesofprotectionofhypoxicischemicbraindamage-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&amp;doi=10.17116%2fjnevro201711712278-86&amp;partnerID=40&amp;md5=76c5f916d4b4f14fdb4d0bd05109ba70', event);\">\n    Modern strategies of protection of hypoxic-ischemic brain damage.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Yanishevsky, S.; Tsygan, N.; Golokhvastov, S.; Andreev, R.; Litvinenko, I.; Karpova, O.;  and Yakovleva, V.\n</span>\n\n  \n\n</span>\n\n  <i>Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova</i>, 117(12): 78-86.  2017.\n  <span class=\"note\">cited By 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&amp;doi=10.17116%2fjnevro201711712278-86&amp;partnerID=40&amp;md5=76c5f916d4b4f14fdb4d0bd05109ba70\"\n     onclick=\"log_download('yanishevsky-tsygan-golokhvastov-andreev-litvinenko-karpova-yakovleva-modernstrategiesofprotectionofhypoxicischemicbraindamage-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&amp;doi=10.17116%2fjnevro201711712278-86&amp;partnerID=40&amp;md5=76c5f916d4b4f14fdb4d0bd05109ba70', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Modern strategies of protection of hypoxic-ischemic brain damage [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.17116/jnevro201711712278-86\"\n     onclick=\"log_download('yanishevsky-tsygan-golokhvastov-andreev-litvinenko-karpova-yakovleva-modernstrategiesofprotectionofhypoxicischemicbraindamage-2017', 'http://doi.org/10.17116/jnevro201711712278-86', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/yanishevsky-tsygan-golokhvastov-andreev-litvinenko-karpova-yakovleva-modernstrategiesofprotectionofhypoxicischemicbraindamage-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('yanishevsky-tsygan-golokhvastov-andreev-litvinenko-karpova-yakovleva-modernstrategiesofprotectionofhypoxicischemicbraindamage-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Yanishevsky201778,\r\nauthor={Yanishevsky, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Andreev, R.V. and Litvinenko, I.V. and Karpova, O.S. and Yakovleva, V.A.},\r\ntitle={Modern strategies of protection of hypoxic-ischemic brain damage},\r\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\r\nyear={2017},\r\nvolume={117},\r\nnumber={12},\r\npages={78-86},\r\ndoi={10.17116/jnevro201711712278-86},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042217241&amp;doi=10.17116%2fjnevro201711712278-86&amp;partnerID=40&amp;md5=76c5f916d4b4f14fdb4d0bd05109ba70},\r\naffiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation},\r\nabstract={Nowadays, there are two complementary approaches to treatment of patients with ischemic stroke: reperfusion and neuroprotection. The main purpose of neuroprotection is to intervene ischemic cascade at every stage of the pathological process and thus avoid the death of nerve cells and expand the therapeutic window for reperfusion therapy. The use of drugs with neurotrophic, antioxidant and neuroregenerative effects is pathogenically explained at all stages of post stroke rehabilitation. Ethylmethylhydroxypyridine succinate (mexidol) is a derivative of succinic acid with antihypoxic, membrane protective, nootropic, anticonvulsant and sedative action. The majority of researchers confirmed the positive effect of mexidol expressed as the marked regression of neurological deficit and wider opportunities for further early rehabilitation. The results of the randomized double blind multicenter placebo-controlled, parallel-group trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA) were published in 2017. The results of the study showed the best positive dynamics of neurological function recovery in case of timely treatment with mexidol with the following two month therapy. The safety of the long-term use of mexidol was confirmed. © 2017, Media Sphera Publishing Group. All rights reserved.},\r\nauthor_keywords={Acute period;  Efficacy of treatment;  Neuroprotection;  Safety of therapy;  Stroke;  Succinate},\r\ncorrespondence_address1={Yanishevsky, S.N.; Kirov Military Medical AcademyRussian Federation; email: stasya71@yandex.ru},\r\npublisher={Media Sphera Publishing Group},\r\nissn={19977298},\r\npubmed_id={29411750},\r\nlanguage={Russian},\r\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Nowadays, there are two complementary approaches to treatment of patients with ischemic stroke: reperfusion and neuroprotection. The main purpose of neuroprotection is to intervene ischemic cascade at every stage of the pathological process and thus avoid the death of nerve cells and expand the therapeutic window for reperfusion therapy. The use of drugs with neurotrophic, antioxidant and neuroregenerative effects is pathogenically explained at all stages of post stroke rehabilitation. Ethylmethylhydroxypyridine succinate (mexidol) is a derivative of succinic acid with antihypoxic, membrane protective, nootropic, anticonvulsant and sedative action. The majority of researchers confirmed the positive effect of mexidol expressed as the marked regression of neurological deficit and wider opportunities for further early rehabilitation. The results of the randomized double blind multicenter placebo-controlled, parallel-group trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA) were published in 2017. The results of the study showed the best positive dynamics of neurological function recovery in case of timely treatment with mexidol with the following two month therapy. The safety of the long-term use of mexidol was confirmed. © 2017, Media Sphera Publishing Group. All rights reserved.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"tsygan-odinak-khubulava-tsygan-peleshok-andreev-kurasov-litvinenko-postoperativecerebraldysfunction-2017\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&amp;doi=10.17116%2fjnevro20171174134-39&amp;partnerID=40&amp;md5=b6de900a49a34dcf567194a67b4eb6cb\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'tsygan-odinak-khubulava-tsygan-peleshok-andreev-kurasov-litvinenko-postoperativecerebraldysfunction-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&amp;doi=10.17116%2fjnevro20171174134-39&amp;partnerID=40&amp;md5=b6de900a49a34dcf567194a67b4eb6cb', event);\">\n    Postoperative cerebral dysfunction.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Tsygan, N.; Odinak, M.; Khubulava, G.; Tsygan, V.; Peleshok, A.; Andreev, R.; Kurasov, E.;  and Litvinenko, I.\n</span>\n\n  \n\n</span>\n\n  <i>Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova</i>, 117(4): 34-39.  2017.\n  <span class=\"note\">cited By 3</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&amp;doi=10.17116%2fjnevro20171174134-39&amp;partnerID=40&amp;md5=b6de900a49a34dcf567194a67b4eb6cb\"\n     onclick=\"log_download('tsygan-odinak-khubulava-tsygan-peleshok-andreev-kurasov-litvinenko-postoperativecerebraldysfunction-2017', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&amp;doi=10.17116%2fjnevro20171174134-39&amp;partnerID=40&amp;md5=b6de900a49a34dcf567194a67b4eb6cb', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Postoperative cerebral dysfunction [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.17116/jnevro20171174134-39\"\n     onclick=\"log_download('tsygan-odinak-khubulava-tsygan-peleshok-andreev-kurasov-litvinenko-postoperativecerebraldysfunction-2017', 'http://doi.org/10.17116/jnevro20171174134-39', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/tsygan-odinak-khubulava-tsygan-peleshok-andreev-kurasov-litvinenko-postoperativecerebraldysfunction-2017\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('tsygan-odinak-khubulava-tsygan-peleshok-andreev-kurasov-litvinenko-postoperativecerebraldysfunction-2017')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Tsygan201734,\r\nauthor={Tsygan, N.V. and Odinak, M.M. and Khubulava, G.G. and Tsygan, V.N. and Peleshok, A.S. and Andreev, R.V. and Kurasov, E.S. and Litvinenko, I.V.},\r\ntitle={Postoperative cerebral dysfunction},\r\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\r\nyear={2017},\r\nvolume={117},\r\nnumber={4},\r\npages={34-39},\r\ndoi={10.17116/jnevro20171174134-39},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020437204&amp;doi=10.17116%2fjnevro20171174134-39&amp;partnerID=40&amp;md5=b6de900a49a34dcf567194a67b4eb6cb},\r\naffiliation={Kirov Military Medical Academy, Saint Petersburg, Russian Federation},\r\nabstract={Objective. To study the structure, risk factors and methods of prevention of postoperative brain dysfunction on the example of coronary artery bypass surgery with cardiopulmonary bypass. Material and methods. The study included 77 patients who undergone elective coronary artery bypass surgery at the beating heart (22 patients) or with cardiopulmonary bypass (55 patients, including 24 patients, who received cerebroprotective treatment with cytoflavin in the preoperative period). All patients underwent dynamic (pre- and postoperative) neurological, neuropsychological, instrumental examinations. Results. The postoperative cerebral dysfunction was diagnosed in 34 (44,2%) patients. The frequency of the clinical types of postoperative cerebral dysfunction significantly differed: perioperative stroke - 3 (3,9%) cases, symptomatic delirium of the early postoperative period - 11 (14,3%) cases, delayed cognitive impairment - 28 (36,4%) cases. The risk factors of postoperative cerebral dysfunction after the coronary artery bypass surgery with cardiopulmonary bypass were identified. Preventive preoperative use of the neuroprotective drug cytoflavin reduces the severity of delayed cognitive impairment after the coronary artery bypass surgery with cardiopulmonary bypass and has a good safety profile. Conclusion. An analysis of the literature data and the results of our own studies show that postoperative cerebral dysfunction is the nosological entity with various etiological factors, pathogenetic mechanisms and the characteristic clinical types, which has an effect on the outcome of surgical treatment. © 2017, Media Sphera, All rights reserved.},\r\nauthor_keywords={Cytoflavin;  Deferred cognitive impairment;  Neuroprotection;  Perioperative stroke;  Postoperative cerebral dysfunction;  Symptomatic delirium of the early postoperative period},\r\npublisher={Media Sphera Publishing Group},\r\nissn={19977298},\r\npubmed_id={28617376},\r\nlanguage={Russian},\r\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objective. To study the structure, risk factors and methods of prevention of postoperative brain dysfunction on the example of coronary artery bypass surgery with cardiopulmonary bypass. Material and methods. The study included 77 patients who undergone elective coronary artery bypass surgery at the beating heart (22 patients) or with cardiopulmonary bypass (55 patients, including 24 patients, who received cerebroprotective treatment with cytoflavin in the preoperative period). All patients underwent dynamic (pre- and postoperative) neurological, neuropsychological, instrumental examinations. Results. The postoperative cerebral dysfunction was diagnosed in 34 (44,2%) patients. The frequency of the clinical types of postoperative cerebral dysfunction significantly differed: perioperative stroke - 3 (3,9%) cases, symptomatic delirium of the early postoperative period - 11 (14,3%) cases, delayed cognitive impairment - 28 (36,4%) cases. The risk factors of postoperative cerebral dysfunction after the coronary artery bypass surgery with cardiopulmonary bypass were identified. Preventive preoperative use of the neuroprotective drug cytoflavin reduces the severity of delayed cognitive impairment after the coronary artery bypass surgery with cardiopulmonary bypass and has a good safety profile. Conclusion. An analysis of the literature data and the results of our own studies show that postoperative cerebral dysfunction is the nosological entity with various etiological factors, pathogenetic mechanisms and the characteristic clinical types, which has an effect on the outcome of surgical treatment. © 2017, Media Sphera, All rights reserved.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2016\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2016')\"\n      onkeypress=\"toggleGroup('group_2016')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2016</span>\n      <span class=\"bibbase_group_count\">\n        \n        (7)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"valeev-trashkov-kovaleko-petrov-vasiliev-sodiumlargininesuccinateanewvasodilatingmedicineforthetreatmentandprophylaxisofdoxorubicininducedcardiotoxicity-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&amp;partnerID=40&amp;md5=16d4946de92f1d75751f52d54696233e\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'valeev-trashkov-kovaleko-petrov-vasiliev-sodiumlargininesuccinateanewvasodilatingmedicineforthetreatmentandprophylaxisofdoxorubicininducedcardiotoxicity-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&amp;partnerID=40&amp;md5=16d4946de92f1d75751f52d54696233e', event);\">\n    Sodium-L-arginine succinate - a new vasodilating medicine for the treatment and prophylaxis of doxorubicin-induced cardiotoxicity.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Valeev, V.; Trashkov; Kovaleko, A.; Petrov, A.;  and Vasiliev, A.\n</span>\n\n  \n\n</span>\n\n  <i>Patologicheskaia fiziologiia i eksperimental'naia terapiia</i>, 60(4): 52-57.  2016.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&amp;partnerID=40&amp;md5=16d4946de92f1d75751f52d54696233e\"\n     onclick=\"log_download('valeev-trashkov-kovaleko-petrov-vasiliev-sodiumlargininesuccinateanewvasodilatingmedicineforthetreatmentandprophylaxisofdoxorubicininducedcardiotoxicity-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&amp;partnerID=40&amp;md5=16d4946de92f1d75751f52d54696233e', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Sodium-L-arginine succinate - a new vasodilating medicine for the treatment and prophylaxis of doxorubicin-induced cardiotoxicity [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/valeev-trashkov-kovaleko-petrov-vasiliev-sodiumlargininesuccinateanewvasodilatingmedicineforthetreatmentandprophylaxisofdoxorubicininducedcardiotoxicity-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('valeev-trashkov-kovaleko-petrov-vasiliev-sodiumlargininesuccinateanewvasodilatingmedicineforthetreatmentandprophylaxisofdoxorubicininducedcardiotoxicity-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Valeev201652,\r\nauthor={Valeev, V.V. and Trashkov and Kovaleko, A.L. and Petrov, A.U. and Vasiliev, A.G.},\r\ntitle={Sodium-L-arginine succinate - a new vasodilating medicine for the treatment and prophylaxis of doxorubicin-induced cardiotoxicity},\r\njournal={Patologicheskaia fiziologiia i eksperimental&#x27;naia terapiia},\r\nyear={2016},\r\nvolume={60},\r\nnumber={4},\r\npages={52-57},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040670041&amp;partnerID=40&amp;md5=16d4946de92f1d75751f52d54696233e},\r\nabstract={The purpose: to ascertain possible cardioprotective effect of Sodium-L-arginine Succinate in case of myocardial lesions caused by Doxorubicin in rats. Methods. The effectiveness of the drug was assessed by morphometric and biochemical changes reflecting peroxidation intensity and structural and functional changes in myocardium. Results. Sodium-L-arginine Succinate used for the treatment and prophylaxis of antracyclic cardiomyopathy was demonstrated to decrease Doxorubicin effects lessening cardiomyocytal destruction and the left ventricular dysfunction with myocardial hypertrophy.},\r\nissn={00312991},\r\npubmed_id={29244923},\r\nlanguage={English},\r\nabbrev_source_title={Patol Fiziol Eksp Ter},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The purpose: to ascertain possible cardioprotective effect of Sodium-L-arginine Succinate in case of myocardial lesions caused by Doxorubicin in rats. Methods. The effectiveness of the drug was assessed by morphometric and biochemical changes reflecting peroxidation intensity and structural and functional changes in myocardium. Results. Sodium-L-arginine Succinate used for the treatment and prophylaxis of antracyclic cardiomyopathy was demonstrated to decrease Doxorubicin effects lessening cardiomyocytal destruction and the left ventricular dysfunction with myocardial hypertrophy.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"panchenko-popovich-trashkov-egormin-yurova-tyndyk-gubareva-artyukin-etal-biomarkersofaginglifespanandspontaneouscarcinogenesisinthewildtypeandher2transgenicfvbnfemalemice-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&amp;doi=10.1007%2fs10522-015-9611-y&amp;partnerID=40&amp;md5=fc4716a4bfbb936f6387a9fcb505bf7e\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'panchenko-popovich-trashkov-egormin-yurova-tyndyk-gubareva-artyukin-etal-biomarkersofaginglifespanandspontaneouscarcinogenesisinthewildtypeandher2transgenicfvbnfemalemice-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&amp;doi=10.1007%2fs10522-015-9611-y&amp;partnerID=40&amp;md5=fc4716a4bfbb936f6387a9fcb505bf7e', event);\">\n    Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Panchenko, A.; Popovich, I.; Trashkov, A.; Egormin, P.; Yurova, M.; Tyndyk, M.; Gubareva, E.; Artyukin, I.; Vasiliev, A.; Khaitsev, N.; Zabezhinski, M.;  and Anisimov, V.\n</span>\n\n  \n\n</span>\n\n  <i>Biogerontology</i>, 17(2): 317-324.  2016.\n  <span class=\"note\">cited By 3</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&amp;doi=10.1007%2fs10522-015-9611-y&amp;partnerID=40&amp;md5=fc4716a4bfbb936f6387a9fcb505bf7e\"\n     onclick=\"log_download('panchenko-popovich-trashkov-egormin-yurova-tyndyk-gubareva-artyukin-etal-biomarkersofaginglifespanandspontaneouscarcinogenesisinthewildtypeandher2transgenicfvbnfemalemice-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&amp;doi=10.1007%2fs10522-015-9611-y&amp;partnerID=40&amp;md5=fc4716a4bfbb936f6387a9fcb505bf7e', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1007/s10522-015-9611-y\"\n     onclick=\"log_download('panchenko-popovich-trashkov-egormin-yurova-tyndyk-gubareva-artyukin-etal-biomarkersofaginglifespanandspontaneouscarcinogenesisinthewildtypeandher2transgenicfvbnfemalemice-2016', 'http://doi.org/10.1007/s10522-015-9611-y', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/panchenko-popovich-trashkov-egormin-yurova-tyndyk-gubareva-artyukin-etal-biomarkersofaginglifespanandspontaneouscarcinogenesisinthewildtypeandher2transgenicfvbnfemalemice-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('panchenko-popovich-trashkov-egormin-yurova-tyndyk-gubareva-artyukin-etal-biomarkersofaginglifespanandspontaneouscarcinogenesisinthewildtypeandher2transgenicfvbnfemalemice-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Panchenko2016317,\r\nauthor={Panchenko, A.V. and Popovich, I.G. and Trashkov, A.P. and Egormin, P.A. and Yurova, M.N. and Tyndyk, M.L. and Gubareva, E.A. and Artyukin, I.N. and Vasiliev, A.G. and Khaitsev, N.V. and Zabezhinski, M.A. and Anisimov, V.N.},\r\ntitle={Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice},\r\njournal={Biogerontology},\r\nyear={2016},\r\nvolume={17},\r\nnumber={2},\r\npages={317-324},\r\ndoi={10.1007/s10522-015-9611-y},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84944519642&amp;doi=10.1007%2fs10522-015-9611-y&amp;partnerID=40&amp;md5=fc4716a4bfbb936f6387a9fcb505bf7e},\r\naffiliation={Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, St. Petersburg, 197758, Russian Federation; St.Petersburg State Pediatric Medical University, 2, Litovskaya str., St. Petersburg, 194100, Russian Federation},\r\nabstract={FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %—800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis. © 2015, Springer Science+Business Media Dordrecht.},\r\nauthor_keywords={Biomarkers of aging;  FVB/N mice;  HER-2/neu;  Life span;  Spontaneous carcinogenesis},\r\ncorrespondence_address1={Anisimov, V.N.; Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, Leningradskaya Str., 68, Pesochny-2, Russian Federation; email: aging@mail.ru},\r\npublisher={Springer Netherlands},\r\nissn={13895729},\r\ncoden={BIOGC},\r\npubmed_id={26423570},\r\nlanguage={English},\r\nabbrev_source_title={Biogerontology},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malonic dialdehyde, catalase, Cu, Zn-superoxide dismutase, vascular endothelial growth factor were studied in both mice strains. The parameters of life span and tumor pathology were studied as well. Cancer-prone transgenic HER-2/neu mice developed in 100 % multiple mammary adenocarcinomas and died before the age of 1 year. Forty tree percent of long-lived wild type mice survived the age of 2 years and 19 %—800 days. The total tumor incidence in wild type mice was 34 %. The age-associated changes in the level of serum IGF-1, glucose and insulin started much earlier in transgene HER-2/neu mice as compared with wild type FVB/N mice. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis. © 2015, Springer Science+Business Media Dordrecht.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"vasllev-trashkov-verlov-kovalenko-petrov-valeev-assessmentofspecificpharmacologicactivityofunifusolonendotheliumdysfunctionmodelinducedbynnitrolargininemethylether-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&amp;partnerID=40&amp;md5=18fb70c18a00b0d7533945e24d527a58\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'vasllev-trashkov-verlov-kovalenko-petrov-valeev-assessmentofspecificpharmacologicactivityofunifusolonendotheliumdysfunctionmodelinducedbynnitrolargininemethylether-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&amp;partnerID=40&amp;md5=18fb70c18a00b0d7533945e24d527a58', event);\">\n    Assessment of specific pharmacologic activity of unifusol on endothelium dysfunction model induced by n-nitro-l-arginine methyl ether.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Vasllev, A.; Trashkov, A.; Verlov, N.; Kovalenko, A.; Petrov, A.;  and Valeev, V.\n</span>\n\n  \n\n</span>\n\n  <i>Eksperimental'naya i Klinicheskaya Farmakologiya</i>, 79(11): 11-14.  2016.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&amp;partnerID=40&amp;md5=18fb70c18a00b0d7533945e24d527a58\"\n     onclick=\"log_download('vasllev-trashkov-verlov-kovalenko-petrov-valeev-assessmentofspecificpharmacologicactivityofunifusolonendotheliumdysfunctionmodelinducedbynnitrolargininemethylether-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&amp;partnerID=40&amp;md5=18fb70c18a00b0d7533945e24d527a58', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Assessment of specific pharmacologic activity of unifusol on endothelium dysfunction model induced by n-nitro-l-arginine methyl ether [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/vasllev-trashkov-verlov-kovalenko-petrov-valeev-assessmentofspecificpharmacologicactivityofunifusolonendotheliumdysfunctionmodelinducedbynnitrolargininemethylether-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('vasllev-trashkov-verlov-kovalenko-petrov-valeev-assessmentofspecificpharmacologicactivityofunifusolonendotheliumdysfunctionmodelinducedbynnitrolargininemethylether-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Vasllev201611,\r\nauthor={Vasllev, A.G. and Trashkov, A.P. and Verlov, N.A. and Kovalenko, A.L. and Petrov, A.Yu. and Valeev, V.V.},\r\ntitle={Assessment of specific pharmacologic activity of unifusol on endothelium dysfunction model induced by n-nitro-l-arginine methyl ether},\r\njournal={Eksperimental&#x27;naya i Klinicheskaya Farmakologiya},\r\nyear={2016},\r\nvolume={79},\r\nnumber={11},\r\npages={11-14},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014867578&amp;partnerID=40&amp;md5=18fb70c18a00b0d7533945e24d527a58},\r\naffiliation={M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, ul. Maurice Thorez44, St. Petersburg, 194223, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, ul. Bekhtereva 1, St. Petersburg, 192019, Russian Federation},\r\nabstract={Specific pharmacologic activity of sodium-L-arginine succinate (unifusol) was studied on endothelium dysfunction model (EDM) in rats. EDM was induced by daily administration of N-nitro-L-arginine methyl ether (L-NAME). The effectiveness of experimental therapy with unifusol was assessed by changes in the arterial pressure level, duration of endothelium-dependent and -independent vasodilation, and the blood concentration of endothelial dysfunction markers including VEGF, NO, endothelin-1 and the number of desquamated endotheliocytes. Administration of unifusol favors correction of blood vessel endothelium state as manifested by normalization of its functional activity and reduction of the apoptosis of endotheliocytes. In addition, the obtained results unambiguously confirm considerable vasodilating and antihypertensive effects of unifusol.},\r\nauthor_keywords={Arterial hypertension;  Endothelial dysfunction;  Rats;  Sodium-L-arginine succinate;  Unifusol;  Vasodilation},\r\npublisher={Izdatel&#x27;stvo Meditsina},\r\nissn={08692092},\r\npubmed_id={29791109},\r\nlanguage={Russian},\r\nabbrev_source_title={Eksp. Klinicheskaya Farmakol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Specific pharmacologic activity of sodium-L-arginine succinate (unifusol) was studied on endothelium dysfunction model (EDM) in rats. EDM was induced by daily administration of N-nitro-L-arginine methyl ether (L-NAME). The effectiveness of experimental therapy with unifusol was assessed by changes in the arterial pressure level, duration of endothelium-dependent and -independent vasodilation, and the blood concentration of endothelial dysfunction markers including VEGF, NO, endothelin-1 and the number of desquamated endotheliocytes. Administration of unifusol favors correction of blood vessel endothelium state as manifested by normalization of its functional activity and reduction of the apoptosis of endotheliocytes. In addition, the obtained results unambiguously confirm considerable vasodilating and antihypertensive effects of unifusol.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"valeev-trashkov-kovalenko-vasilev-pathophysiologicalandclinicalaspectsofusinglarginineincardiologyandangiologypatofiziologicheskieiklinicheskieaspektyprimeneniialargininavkardiologiiiangiologii-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&amp;partnerID=40&amp;md5=0a98563798c83c8637d1362f919aff13\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'valeev-trashkov-kovalenko-vasilev-pathophysiologicalandclinicalaspectsofusinglarginineincardiologyandangiologypatofiziologicheskieiklinicheskieaspektyprimeneniialargininavkardiologiiiangiologii-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&amp;partnerID=40&amp;md5=0a98563798c83c8637d1362f919aff13', event);\">\n    Pathophysiological and clinical aspects of using L-arginine in cardiology and angiology [Patofiziologicheskie i klinicheskie aspekty primeneniia L-arginina v kardiologii i angiologii].\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Valeev, V.; Trashkov, A.; Kovalenko, A.;  and Vasil'ev, A.\n</span>\n\n  \n\n</span>\n\n  <i>Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery</i>, 22(3): 9-15.  2016.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&amp;partnerID=40&amp;md5=0a98563798c83c8637d1362f919aff13\"\n     onclick=\"log_download('valeev-trashkov-kovalenko-vasilev-pathophysiologicalandclinicalaspectsofusinglarginineincardiologyandangiologypatofiziologicheskieiklinicheskieaspektyprimeneniialargininavkardiologiiiangiologii-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&amp;partnerID=40&amp;md5=0a98563798c83c8637d1362f919aff13', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Pathophysiological and clinical aspects of using L-arginine in cardiology and angiology [Patofiziologicheskie i klinicheskie aspekty primeneniia L-arginina v kardiologii i angiologii] [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/valeev-trashkov-kovalenko-vasilev-pathophysiologicalandclinicalaspectsofusinglarginineincardiologyandangiologypatofiziologicheskieiklinicheskieaspektyprimeneniialargininavkardiologiiiangiologii-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('valeev-trashkov-kovalenko-vasilev-pathophysiologicalandclinicalaspectsofusinglarginineincardiologyandangiologypatofiziologicheskieiklinicheskieaspektyprimeneniialargininavkardiologiiiangiologii-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Valeev20169,\r\nauthor={Valeev, V.V. and Trashkov, A.P. and Kovalenko, A.L. and Vasil&#x27;ev, A.G.},\r\ntitle={Pathophysiological and clinical aspects of using L-arginine in cardiology and angiology [Patofiziologicheskie i klinicheskie aspekty primeneniia L-arginina v kardiologii i angiologii]},\r\njournal={Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery},\r\nyear={2016},\r\nvolume={22},\r\nnumber={3},\r\npages={9-15},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020374895&amp;partnerID=40&amp;md5=0a98563798c83c8637d1362f919aff13},\r\naffiliation={Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation; Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation; Saint Petersburg State Paediatric Medical University, Moscow, Russian Federation},\r\nabstract={Presented herein is a review of scientific publications dedicated to studying the pharmacodynamics of L-arginine and possibilities of its clinical application. Interest to L-arginine is associated, first of all, with its role as a precursor in endogenous synthesis of nitric oxide (NO), playing an important role in regulation of the functional state of the vascular wall. According to numerous studies, oral and parenteral administration of L-arginine restores endothelial production of NO in such diseases as atherosclerosis, hypertension, type 2 diabetes mellitus, obliterating diseases of arteries of lower extremities. The NO-mediated effect of L-arginine manifests itself in increasing the capability of vessels to dilatation, decreasing blood platelet aggregation, and inhibiting proliferation of smooth muscle cells of vessels. The effect is most pronounced in patients presenting with hypercholesterolaemia and initially decreased reactivity of the blood channel. The mostly pronounced NO-mediated effect of L-arginine is observed in parenteral route of its administration. Prolonged administration of L-arginine slows down progression of atherosclerosis.},\r\nissn={10276661},\r\npubmed_id={27626244},\r\nlanguage={Russian},\r\nabbrev_source_title={Angiol Sosud Khir},\r\ndocument_type={Review},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Presented herein is a review of scientific publications dedicated to studying the pharmacodynamics of L-arginine and possibilities of its clinical application. Interest to L-arginine is associated, first of all, with its role as a precursor in endogenous synthesis of nitric oxide (NO), playing an important role in regulation of the functional state of the vascular wall. According to numerous studies, oral and parenteral administration of L-arginine restores endothelial production of NO in such diseases as atherosclerosis, hypertension, type 2 diabetes mellitus, obliterating diseases of arteries of lower extremities. The NO-mediated effect of L-arginine manifests itself in increasing the capability of vessels to dilatation, decreasing blood platelet aggregation, and inhibiting proliferation of smooth muscle cells of vessels. The effect is most pronounced in patients presenting with hypercholesterolaemia and initially decreased reactivity of the blood channel. The mostly pronounced NO-mediated effect of L-arginine is observed in parenteral route of its administration. Prolonged administration of L-arginine slows down progression of atherosclerosis.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"erkudov-pugovkin-verlov-sergeev-ievkov-systemicerrorsintheestimationofsystemicarterialpressureviatransferfunctionsafterexperimentalchangesofthecirculatingbloodvolume-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&amp;partnerID=40&amp;md5=6367ac191f1141256d9dbfd57e6f43a1\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'erkudov-pugovkin-verlov-sergeev-ievkov-systemicerrorsintheestimationofsystemicarterialpressureviatransferfunctionsafterexperimentalchangesofthecirculatingbloodvolume-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&amp;partnerID=40&amp;md5=6367ac191f1141256d9dbfd57e6f43a1', event);\">\n    Systemic errors in the estimation of systemic arterial pressure via transfer functions after experimental changes of the circulating blood volume.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Erkudov, V.; Pugovkin, A.; Verlov, N.; Sergeev, I.;  and Ievkov, S.\n</span>\n\n  \n\n</span>\n\n  <i>Patologicheskaia fiziologiia i eksperimental'naia terapiia</i>, 60(1): 45-49.  2016.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&amp;partnerID=40&amp;md5=6367ac191f1141256d9dbfd57e6f43a1\"\n     onclick=\"log_download('erkudov-pugovkin-verlov-sergeev-ievkov-systemicerrorsintheestimationofsystemicarterialpressureviatransferfunctionsafterexperimentalchangesofthecirculatingbloodvolume-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&amp;partnerID=40&amp;md5=6367ac191f1141256d9dbfd57e6f43a1', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Systemic errors in the estimation of systemic arterial pressure via transfer functions after experimental changes of the circulating blood volume [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/erkudov-pugovkin-verlov-sergeev-ievkov-systemicerrorsintheestimationofsystemicarterialpressureviatransferfunctionsafterexperimentalchangesofthecirculatingbloodvolume-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('erkudov-pugovkin-verlov-sergeev-ievkov-systemicerrorsintheestimationofsystemicarterialpressureviatransferfunctionsafterexperimentalchangesofthecirculatingbloodvolume-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Erkudov201645,\r\nauthor={Erkudov, V.O. and Pugovkin, A.P. and Verlov, N.A. and Sergeev, I.V. and Ievkov, S.A.},\r\ntitle={Systemic errors in the estimation of systemic arterial pressure via transfer functions after experimental changes of the circulating blood volume},\r\njournal={Patologicheskaia fiziologiia i eksperimental&#x27;naia terapiia},\r\nyear={2016},\r\nvolume={60},\r\nnumber={1},\r\npages={45-49},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038641630&amp;partnerID=40&amp;md5=6367ac191f1141256d9dbfd57e6f43a1},\r\nabstract={The results of the experimental studies reveal the decrease of vascular rigidity with the increase of systemic error of the arterial pressure values estimated via implication of transfer functions following haemorrhage modeling in rats. Compensation of the circulating blood volume by means of dextran infusion resulted in restoration of both vascular rigidity and systemic error of estimated arterial pressure. The results can be put into medical practice as an approach for testing of non-invasive methods in cardiovascular research.},\r\nissn={00312991},\r\npubmed_id={29215248},\r\nlanguage={Russian},\r\nabbrev_source_title={Patol Fiziol Eksp Ter},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The results of the experimental studies reveal the decrease of vascular rigidity with the increase of systemic error of the arterial pressure values estimated via implication of transfer functions following haemorrhage modeling in rats. Compensation of the circulating blood volume by means of dextran infusion resulted in restoration of both vascular rigidity and systemic error of estimated arterial pressure. The results can be put into medical practice as an approach for testing of non-invasive methods in cardiovascular research.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"trashkov-vasilev-kovalenko-petrov-valeev-influenceofangioprotectordrugsontheefficacyofcytostatictherapyexperimentalstudy-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&amp;partnerID=40&amp;md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'trashkov-vasilev-kovalenko-petrov-valeev-influenceofangioprotectordrugsontheefficacyofcytostatictherapyexperimentalstudy-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&amp;partnerID=40&amp;md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4', event);\">\n    Influence of angioprotector drugs on the efficacy of cytostatic therapy (experimental study).\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Trashkov, A.; Vasil'Ev, A.; Kovalenko, A.; Petrov, A.;  and Valeev, V.\n</span>\n\n  \n\n</span>\n\n  <i>Eksperimental'naya i Klinicheskaya Farmakologiya</i>, 79(2): 34-39.  2016.\n  <span class=\"note\">cited By 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&amp;partnerID=40&amp;md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4\"\n     onclick=\"log_download('trashkov-vasilev-kovalenko-petrov-valeev-influenceofangioprotectordrugsontheefficacyofcytostatictherapyexperimentalstudy-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&amp;partnerID=40&amp;md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Influence of angioprotector drugs on the efficacy of cytostatic therapy (experimental study) [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/trashkov-vasilev-kovalenko-petrov-valeev-influenceofangioprotectordrugsontheefficacyofcytostatictherapyexperimentalstudy-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('trashkov-vasilev-kovalenko-petrov-valeev-influenceofangioprotectordrugsontheefficacyofcytostatictherapyexperimentalstudy-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Trashkov201634,\r\nauthor={Trashkov, A.P. and Vasil&#x27;Ev, A.G. and Kovalenko, A.L. and Petrov, A.Yu. and Valeev, V.V.},\r\ntitle={Influence of angioprotector drugs on the efficacy of cytostatic therapy (experimental study)},\r\njournal={Eksperimental&#x27;naya i Klinicheskaya Farmakologiya},\r\nyear={2016},\r\nvolume={79},\r\nnumber={2},\r\npages={34-39},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976525082&amp;partnerID=40&amp;md5=99c9fe0d4a7b3eb49dcb62ac0a3504c4},\r\naffiliation={St. Petersburg State Pediatric Medical University, Ul. Litovskaya 2, St.-Petersburg, 194100, Russian Federation; Institute of Toxicology, Federal Medico-Biological Agency, Ul. Bekhtereva 1, St.-Petersburg, 192019, Russian Federation},\r\nabstract={The influence of angioprotector and endothelium-protector drugs pentoxifylline and unifuzol as components of supportive therapy on the efficacy of combined cytostatic treatment has been experimentally studied. It is established that pentoxifylline and unifuzol do not affect the antitumor and antimetastatic activity of doxorubicin and cyclophosphan with respect to Pliss lymphosarcoma and Walker 256 carcinosarcoma, and in some cases even potentiate the effect of cytostatic therapy.},\r\nauthor_keywords={Cytostatic therapy;  Pentoxifylline;  Pliss lymphosarcoma;  Succinic acid;  Tumor;  Unifuzol;  Walker 256 carcinosarcoma},\r\npublisher={Izdatel&#x27;stvo Meditsina},\r\nissn={08692092},\r\npubmed_id={27416681},\r\nlanguage={Russian},\r\nabbrev_source_title={Eksp. Klinicheskaya Farmakol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The influence of angioprotector and endothelium-protector drugs pentoxifylline and unifuzol as components of supportive therapy on the efficacy of combined cytostatic treatment has been experimentally studied. It is established that pentoxifylline and unifuzol do not affect the antitumor and antimetastatic activity of doxorubicin and cyclophosphan with respect to Pliss lymphosarcoma and Walker 256 carcinosarcoma, and in some cases even potentiate the effect of cytostatic therapy.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"odinak-voznyuk-yanishevsky-golokhvastov-tsygan-polushin-andreev-mirnaya-opportunitiesinmultimodalneuroimagingforoptimizingthrombolytictherapyforischemicstroke-2016\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&amp;doi=10.14412%2f2074-2711-2016-1-9-15&amp;partnerID=40&amp;md5=f1c8a704d6aab179148bfb1ddbad5891\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'odinak-voznyuk-yanishevsky-golokhvastov-tsygan-polushin-andreev-mirnaya-opportunitiesinmultimodalneuroimagingforoptimizingthrombolytictherapyforischemicstroke-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&amp;doi=10.14412%2f2074-2711-2016-1-9-15&amp;partnerID=40&amp;md5=f1c8a704d6aab179148bfb1ddbad5891', event);\">\n    Opportunities in multimodal neuroimaging for optimizing thrombolytic therapy for ischemic stroke.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Odinak, M.; Voznyuk, I.; Yanishevsky, S.; Golokhvastov, S.; Tsygan, N.; Polushin, A.; Andreev, R.;  and Mirnaya, D.\n</span>\n\n  \n\n</span>\n\n  <i>Nevrologiya, Neiropsikhiatriya, Psikhosomatika</i>, 8(1): 9-15.  2016.\n  <span class=\"note\">cited By 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&amp;doi=10.14412%2f2074-2711-2016-1-9-15&amp;partnerID=40&amp;md5=f1c8a704d6aab179148bfb1ddbad5891\"\n     onclick=\"log_download('odinak-voznyuk-yanishevsky-golokhvastov-tsygan-polushin-andreev-mirnaya-opportunitiesinmultimodalneuroimagingforoptimizingthrombolytictherapyforischemicstroke-2016', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&amp;doi=10.14412%2f2074-2711-2016-1-9-15&amp;partnerID=40&amp;md5=f1c8a704d6aab179148bfb1ddbad5891', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Opportunities in multimodal neuroimaging for optimizing thrombolytic therapy for ischemic stroke [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.14412/2074-2711-2016-1-9-15\"\n     onclick=\"log_download('odinak-voznyuk-yanishevsky-golokhvastov-tsygan-polushin-andreev-mirnaya-opportunitiesinmultimodalneuroimagingforoptimizingthrombolytictherapyforischemicstroke-2016', 'http://doi.org/10.14412/2074-2711-2016-1-9-15', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/odinak-voznyuk-yanishevsky-golokhvastov-tsygan-polushin-andreev-mirnaya-opportunitiesinmultimodalneuroimagingforoptimizingthrombolytictherapyforischemicstroke-2016\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('odinak-voznyuk-yanishevsky-golokhvastov-tsygan-polushin-andreev-mirnaya-opportunitiesinmultimodalneuroimagingforoptimizingthrombolytictherapyforischemicstroke-2016')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Odinak20169,\r\nauthor={Odinak, M.M. and Voznyuk, I.A. and Yanishevsky, S.N. and Golokhvastov, S.Y. and Tsygan, N.V. and Polushin, A.Yu. and Andreev, R.V. and Mirnaya, D.A.},\r\ntitle={Opportunities in multimodal neuroimaging for optimizing thrombolytic therapy for ischemic stroke},\r\njournal={Nevrologiya, Neiropsikhiatriya, Psikhosomatika},\r\nyear={2016},\r\nvolume={8},\r\nnumber={1},\r\npages={9-15},\r\ndoi={10.14412/2074-2711-2016-1-9-15},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017222385&amp;doi=10.14412%2f2074-2711-2016-1-9-15&amp;partnerID=40&amp;md5=f1c8a704d6aab179148bfb1ddbad5891},\r\naffiliation={S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg, 6, Academician Lebedev St., Saint Petersburg, 194044, Russian Federation},\r\nabstract={The main purpose of examination of patients before thrombolytic therapy for ischemic stroke (IS) is to timely identify contraindications to the use of recombinant tissue plasminogen activator. Objective: to estimate opportunities and benefits in applying multimodal magnetic resonance imaging (MRI) to improve clinical outcomes in acute stroke, among other processes, by enhancing the efficiency and safety of thrombolytic therapy. Patients and methods. The clinical experience of the S.M. Kirov Military Medical Academy in using multimodal MRI of the brain since 2004 was analyzed in patients with stroke. Results. Comprehensive assessment of the results of perfusion-weighted MRI of the brain and those of transcranial Doppler ultrasound identified five clinically significant variants of perfusion changes in IS: normal perfusion; postischemic hyperemia; persistent hypoperfusion; acute pathological hyperperfusion, and unrecovered perfusion. With an irreversible tissue damage volume of &amp;gt;60 cm3 on day 1 of stroke, as evidenced by diffusion-weighted MRI, the odd ratio for cerebral edema in the acutest period of the disease is 39.4% (95% CI 2.57-2436; p&amp;lt;0.05). The risk of hemorrhagic transformation increases with a measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct &amp;lt;35×10-5 mm2/sec within the first 24 hours after disease onset (p&amp;lt;0.005). Conclusion. The data of local clinical practice and the results of international clinical trials show that multimodal MRI of the brain is a reliable tool for the detailed evaluation of the expected efficiency and safety of thrombolytic therapy for IS. When persistent hypoperfusion is detected, the determination of perfusion-diffusion mismatch is of no informative value in deciding on whether thrombolytic therapy can be performed. Estimating the volume of pathological changes on diffusion-weighted images and the measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct in the measured diffusion coefficient maps allows the risk of major intracranial complications due to IS to be identified.},\r\nauthor_keywords={Diffusionweighted magnetic resonance imaging;  Intracranial complications due to stroke;  Ischemic stroke;  Multimodal neuroimaging;  Perfusion-weighted magnetic resonance imaging;  Thrombolytic therapy;  Variants of perfusion changes},\r\ncorrespondence_address1={Yanishevsky, S.N.; S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg, 6, Academician Lebedev St., Russian Federation; email: stasya71@yandex.ru},\r\npublisher={Ima-Press Publishing House},\r\nissn={20742711},\r\nlanguage={Russian},\r\nabbrev_source_title={Nevrol. Neiropsikhiatr. Psikhosomat.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The main purpose of examination of patients before thrombolytic therapy for ischemic stroke (IS) is to timely identify contraindications to the use of recombinant tissue plasminogen activator. Objective: to estimate opportunities and benefits in applying multimodal magnetic resonance imaging (MRI) to improve clinical outcomes in acute stroke, among other processes, by enhancing the efficiency and safety of thrombolytic therapy. Patients and methods. The clinical experience of the S.M. Kirov Military Medical Academy in using multimodal MRI of the brain since 2004 was analyzed in patients with stroke. Results. Comprehensive assessment of the results of perfusion-weighted MRI of the brain and those of transcranial Doppler ultrasound identified five clinically significant variants of perfusion changes in IS: normal perfusion; postischemic hyperemia; persistent hypoperfusion; acute pathological hyperperfusion, and unrecovered perfusion. With an irreversible tissue damage volume of &gt;60 cm3 on day 1 of stroke, as evidenced by diffusion-weighted MRI, the odd ratio for cerebral edema in the acutest period of the disease is 39.4% (95% CI 2.57-2436; p&lt;0.05). The risk of hemorrhagic transformation increases with a measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct &lt;35×10-5 mm2/sec within the first 24 hours after disease onset (p&lt;0.005). Conclusion. The data of local clinical practice and the results of international clinical trials show that multimodal MRI of the brain is a reliable tool for the detailed evaluation of the expected efficiency and safety of thrombolytic therapy for IS. When persistent hypoperfusion is detected, the determination of perfusion-diffusion mismatch is of no informative value in deciding on whether thrombolytic therapy can be performed. Estimating the volume of pathological changes on diffusion-weighted images and the measured diffusion coefficient in the area of the nucleus of developing nonlacunar infarct in the measured diffusion coefficient maps allows the risk of major intracranial complications due to IS to be identified.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2015\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2015')\"\n      onkeypress=\"toggleGroup('group_2015')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2015</span>\n      <span class=\"bibbase_group_count\">\n        \n        (7)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"karabanov-verlov-suvorov-gololobov-slivkin-propertiesofcontactcoatingsbasedonrutheniumnanofilmsformemsswitches-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&amp;doi=10.1134%2fS1063785015070226&amp;partnerID=40&amp;md5=7efd35505f6a5b7c2f8c867e82b0ac4a\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'karabanov-verlov-suvorov-gololobov-slivkin-propertiesofcontactcoatingsbasedonrutheniumnanofilmsformemsswitches-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&amp;doi=10.1134%2fS1063785015070226&amp;partnerID=40&amp;md5=7efd35505f6a5b7c2f8c867e82b0ac4a', event);\">\n    Properties of contact coatings based on ruthenium nanofilms for MEMS switches.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Karabanov, S.; Verlov, N.; Suvorov, D.; Gololobov, G.;  and Slivkin, E.\n</span>\n\n  \n\n</span>\n\n  <i>Technical Physics Letters</i>, 41(7): 691-693.  2015.\n  <span class=\"note\">cited By 2</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&amp;doi=10.1134%2fS1063785015070226&amp;partnerID=40&amp;md5=7efd35505f6a5b7c2f8c867e82b0ac4a\"\n     onclick=\"log_download('karabanov-verlov-suvorov-gololobov-slivkin-propertiesofcontactcoatingsbasedonrutheniumnanofilmsformemsswitches-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&amp;doi=10.1134%2fS1063785015070226&amp;partnerID=40&amp;md5=7efd35505f6a5b7c2f8c867e82b0ac4a', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Properties of contact coatings based on ruthenium nanofilms for MEMS switches [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1134/S1063785015070226\"\n     onclick=\"log_download('karabanov-verlov-suvorov-gololobov-slivkin-propertiesofcontactcoatingsbasedonrutheniumnanofilmsformemsswitches-2015', 'http://doi.org/10.1134/S1063785015070226', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/karabanov-verlov-suvorov-gololobov-slivkin-propertiesofcontactcoatingsbasedonrutheniumnanofilmsformemsswitches-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('karabanov-verlov-suvorov-gololobov-slivkin-propertiesofcontactcoatingsbasedonrutheniumnanofilmsformemsswitches-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Karabanov2015691,\r\nauthor={Karabanov, S.M. and Verlov, N.A. and Suvorov, D.V. and Gololobov, G.P. and Slivkin, E.V.},\r\ntitle={Properties of contact coatings based on ruthenium nanofilms for MEMS switches},\r\njournal={Technical Physics Letters},\r\nyear={2015},\r\nvolume={41},\r\nnumber={7},\r\npages={691-693},\r\ndoi={10.1134/S1063785015070226},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938363427&amp;doi=10.1134%2fS1063785015070226&amp;partnerID=40&amp;md5=7efd35505f6a5b7c2f8c867e82b0ac4a},\r\naffiliation={Ryazan State Radioengineering University, Ryazan, 390005, Russian Federation},\r\nabstract={Switching properties of contact coatings based on ruthenium nanofilms obtained by electrochemical deposition have been studied. The laws of variation of the contact resistance as a function of the number of switching cycles are established as dependent on the coating thickness and surface roughness. Optimum parameters of contact coatings are determined that ensure minimum contact resistance of switches for micro-electromechanical systems (MEMS) operating in steady-state regimes. © 2015, Pleiades Publishing, Ltd.},\r\ncorrespondence_address1={Suvorov, D.V.; Ryazan State Radioengineering UniversityRussian Federation},\r\npublisher={Maik Nauka-Interperiodica Publishing},\r\nissn={10637850},\r\nlanguage={English},\r\nabbrev_source_title={Tech. Phys. Lett.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Switching properties of contact coatings based on ruthenium nanofilms obtained by electrochemical deposition have been studied. The laws of variation of the contact resistance as a function of the number of switching cycles are established as dependent on the coating thickness and surface roughness. Optimum parameters of contact coatings are determined that ensure minimum contact resistance of switches for micro-electromechanical systems (MEMS) operating in steady-state regimes. © 2015, Pleiades Publishing, Ltd.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"odinak-yanishevskii-tsygan-golokhvastov-voznyuk-trufanov-useofsuccinatesforcorrectionofmetabolicimpairmentsintheischemicpenumbrazoneinstrokepatients-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&amp;doi=10.1007%2fs11055-015-0118-4&amp;partnerID=40&amp;md5=985c7310b65123e7f0e76e00e7df1c26\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'odinak-yanishevskii-tsygan-golokhvastov-voznyuk-trufanov-useofsuccinatesforcorrectionofmetabolicimpairmentsintheischemicpenumbrazoneinstrokepatients-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&amp;doi=10.1007%2fs11055-015-0118-4&amp;partnerID=40&amp;md5=985c7310b65123e7f0e76e00e7df1c26', event);\">\n    Use of Succinates for Correction of Metabolic Impairments in the Ischemic Penumbra Zone in Stroke Patients.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Odinak, M.; Yanishevskii, S.; Tsygan, N.; Golokhvastov, S.; Voznyuk, I.;  and Trufanov, A.\n</span>\n\n  \n\n</span>\n\n  <i>Neuroscience and Behavioral Physiology</i>, 45(5): 600-604.  2015.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&amp;doi=10.1007%2fs11055-015-0118-4&amp;partnerID=40&amp;md5=985c7310b65123e7f0e76e00e7df1c26\"\n     onclick=\"log_download('odinak-yanishevskii-tsygan-golokhvastov-voznyuk-trufanov-useofsuccinatesforcorrectionofmetabolicimpairmentsintheischemicpenumbrazoneinstrokepatients-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&amp;doi=10.1007%2fs11055-015-0118-4&amp;partnerID=40&amp;md5=985c7310b65123e7f0e76e00e7df1c26', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Use of Succinates for Correction of Metabolic Impairments in the Ischemic Penumbra Zone in Stroke Patients [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1007/s11055-015-0118-4\"\n     onclick=\"log_download('odinak-yanishevskii-tsygan-golokhvastov-voznyuk-trufanov-useofsuccinatesforcorrectionofmetabolicimpairmentsintheischemicpenumbrazoneinstrokepatients-2015', 'http://doi.org/10.1007/s11055-015-0118-4', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/odinak-yanishevskii-tsygan-golokhvastov-voznyuk-trufanov-useofsuccinatesforcorrectionofmetabolicimpairmentsintheischemicpenumbrazoneinstrokepatients-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('odinak-yanishevskii-tsygan-golokhvastov-voznyuk-trufanov-useofsuccinatesforcorrectionofmetabolicimpairmentsintheischemicpenumbrazoneinstrokepatients-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Odinak2015600,\r\nauthor={Odinak, M.M. and Yanishevskii, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Voznyuk, I.A. and Trufanov, A.G.},\r\ntitle={Use of Succinates for Correction of Metabolic Impairments in the Ischemic Penumbra Zone in Stroke Patients},\r\njournal={Neuroscience and Behavioral Physiology},\r\nyear={2015},\r\nvolume={45},\r\nnumber={5},\r\npages={600-604},\r\ndoi={10.1007/s11055-015-0118-4},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953359856&amp;doi=10.1007%2fs11055-015-0118-4&amp;partnerID=40&amp;md5=985c7310b65123e7f0e76e00e7df1c26},\r\naffiliation={Department of Nervous Diseases, Kirov Military Medical Academy, St. Petersburg, Russian Federation},\r\nabstract={The aim of the present work was to use MR spectroscopy to assess the quantitative contents and ratios of different metabolites in the infarct nucleus, ischemic penumbra, and unaltered tissue in the opposite hemisphere in patients in the acute period of ischemic stroke. A total of 72 patients were studied, of whom 37 (the study group) received the antioxidant Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) in addition to basal treatment, while 35 patients received only standard treatment without use of antioxidants. Stroke severity was assessed on the NIHSS scale and functional outcomes on day 30 were evaluated using the Bartel index and modified Rankin scale. MR proton spectroscopy was performed twice: during the first 24 h of disease onset and on day 5. Use of the succinate-containing antioxidant Mexidol (500 mg i.v. for 14 days) during the acute period of ischemic stroke significantly decreased the intracellular lactate (p = 0.002) and inositol contents (p = 0.005) from the levels in the control group, which helped restore the balance between the aerobic and anaerobic mechanisms of oxidation and had favorable influences on the rehabilitation potentials of the patients. A positive correlation was found between the lactate content in the ischemic penumbra zone and values on the NIHSS (r = 0.5786, p = 0.049), along with a negative correlation between the lactate content in the ischemic penumbra zone and the level of functional recovery assessed on the Bartel index (r = –0.6305, p = 0.028), which supports the existence of an interaction between impaired glucose metabolism in hypoxic conditions and the level of injury to nervous tissue. © 2015, Springer Science+Business Media New York.},\r\nauthor_keywords={antioxidants;  ischemic stroke;  magnetic resonance spectroscopy;  Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate)},\r\ncorrespondence_address1={Yanishevskii, S.N.; Department of Nervous Diseases, Kirov Military Medical AcademyRussian Federation; email: stasya71@yandex.ru},\r\npublisher={Springer New York LLC},\r\nissn={00970549},\r\ncoden={NBHPB},\r\nlanguage={English},\r\nabbrev_source_title={Neurosci. Behav. Physiol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The aim of the present work was to use MR spectroscopy to assess the quantitative contents and ratios of different metabolites in the infarct nucleus, ischemic penumbra, and unaltered tissue in the opposite hemisphere in patients in the acute period of ischemic stroke. A total of 72 patients were studied, of whom 37 (the study group) received the antioxidant Mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) in addition to basal treatment, while 35 patients received only standard treatment without use of antioxidants. Stroke severity was assessed on the NIHSS scale and functional outcomes on day 30 were evaluated using the Bartel index and modified Rankin scale. MR proton spectroscopy was performed twice: during the first 24 h of disease onset and on day 5. Use of the succinate-containing antioxidant Mexidol (500 mg i.v. for 14 days) during the acute period of ischemic stroke significantly decreased the intracellular lactate (p = 0.002) and inositol contents (p = 0.005) from the levels in the control group, which helped restore the balance between the aerobic and anaerobic mechanisms of oxidation and had favorable influences on the rehabilitation potentials of the patients. A positive correlation was found between the lactate content in the ischemic penumbra zone and values on the NIHSS (r = 0.5786, p = 0.049), along with a negative correlation between the lactate content in the ischemic penumbra zone and the level of functional recovery assessed on the Bartel index (r = –0.6305, p = 0.028), which supports the existence of an interaction between impaired glucose metabolism in hypoxic conditions and the level of injury to nervous tissue. © 2015, Springer Science+Business Media New York.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"trashkov-panchenko-kayukova-korablev-pechatnikova-vasilev-anisimov-p388leukemiaincdf1miceasthetestsystemforstudiesoftumorassociatedneoangiogenesisandhypercoagulation-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&amp;doi=10.1007%2fs10517-015-2793-0&amp;partnerID=40&amp;md5=aa6957c053dc95e316a5743556578173\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'trashkov-panchenko-kayukova-korablev-pechatnikova-vasilev-anisimov-p388leukemiaincdf1miceasthetestsystemforstudiesoftumorassociatedneoangiogenesisandhypercoagulation-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&amp;doi=10.1007%2fs10517-015-2793-0&amp;partnerID=40&amp;md5=aa6957c053dc95e316a5743556578173', event);\">\n    P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Trashkov, A.; Panchenko, A.; Kayukova, E.; Korablev, R.; Pechatnikova, V.; Vasil’ev, A.;  and Anisimov, V.\n</span>\n\n  \n\n</span>\n\n  <i>Bulletin of Experimental Biology and Medicine</i>, 158(4): 497-499.  2015.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&amp;doi=10.1007%2fs10517-015-2793-0&amp;partnerID=40&amp;md5=aa6957c053dc95e316a5743556578173\"\n     onclick=\"log_download('trashkov-panchenko-kayukova-korablev-pechatnikova-vasilev-anisimov-p388leukemiaincdf1miceasthetestsystemforstudiesoftumorassociatedneoangiogenesisandhypercoagulation-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&amp;doi=10.1007%2fs10517-015-2793-0&amp;partnerID=40&amp;md5=aa6957c053dc95e316a5743556578173', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.1007/s10517-015-2793-0\"\n     onclick=\"log_download('trashkov-panchenko-kayukova-korablev-pechatnikova-vasilev-anisimov-p388leukemiaincdf1miceasthetestsystemforstudiesoftumorassociatedneoangiogenesisandhypercoagulation-2015', 'http://doi.org/10.1007/s10517-015-2793-0', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/trashkov-panchenko-kayukova-korablev-pechatnikova-vasilev-anisimov-p388leukemiaincdf1miceasthetestsystemforstudiesoftumorassociatedneoangiogenesisandhypercoagulation-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('trashkov-panchenko-kayukova-korablev-pechatnikova-vasilev-anisimov-p388leukemiaincdf1miceasthetestsystemforstudiesoftumorassociatedneoangiogenesisandhypercoagulation-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Trashkov2015497,\r\nauthor={Trashkov, A.P. and Panchenko, A.V. and Kayukova, E.S. and Korablev, R.V. and Pechatnikova, V.A. and Vasil’ev, A.G. and Anisimov, V.N.},\r\ntitle={P388 Leukemia in CDF1 Mice as the Test System for Studies of Tumor-Associated Neoangiogenesis and Hypercoagulation},\r\njournal={Bulletin of Experimental Biology and Medicine},\r\nyear={2015},\r\nvolume={158},\r\nnumber={4},\r\npages={497-499},\r\ndoi={10.1007/s10517-015-2793-0},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952717652&amp;doi=10.1007%2fs10517-015-2793-0&amp;partnerID=40&amp;md5=aa6957c053dc95e316a5743556578173},\r\naffiliation={St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation; N. N. Petrov Research Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russian Federation},\r\nabstract={Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia. © 2015, Springer Science+Business Media New York.},\r\nauthor_keywords={hemostasis;  neoangiogenesis;  P-388 leukemia;  tumor;  vascular endothelial growth factor},\r\ncorrespondence_address1={Trashkov, A.P.; St. Petersburg State Pediatric Medical University, the Ministry of Health of the Russian FederationRussian Federation; email: alexandr.trashkov@gmail.com},\r\npublisher={Springer New York LLC},\r\nissn={00074888},\r\ncoden={BEXBA},\r\npubmed_id={25708334},\r\nlanguage={English},\r\nabbrev_source_title={Bull. Exp. Biol. Med.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Blood levels of vascular endothelial growth factor, the main marker of angiogenesis activity, and coagulation hemostasis were studied in CDF1 mice with transplanted P-388 lymphocytic leukemia. Blood levels of vascular endothelial growth factor increased by 168% in mice with tumors. The animals developed the hypercoagulation syndrome manifesting in shorter activated partial thromboplastin time and prothrombin time and development of hyperfibrinogenemia. © 2015, Springer Science+Business Media New York.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"tsygan-trashkov-yakovleva-malkova-gracheva-kovalenko-vasiliev-characteristicsoftheregulationofneurotrophicmechanismsinischemicstroke-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&amp;doi=10.17116%2fjnevro201511571112-116&amp;partnerID=40&amp;md5=d627b1d1e0674d0be3e6fa7af2c09a99\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'tsygan-trashkov-yakovleva-malkova-gracheva-kovalenko-vasiliev-characteristicsoftheregulationofneurotrophicmechanismsinischemicstroke-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&amp;doi=10.17116%2fjnevro201511571112-116&amp;partnerID=40&amp;md5=d627b1d1e0674d0be3e6fa7af2c09a99', event);\">\n    Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Tsygan, N.; Trashkov, A.; Yakovleva, V.; Malkova, V.; Gracheva, E.; Kovalenko, A.;  and Vasiliev, A.\n</span>\n\n  \n\n</span>\n\n  <i>Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova</i>, 2015(7): 112-116.  2015.\n  <span class=\"note\">cited By 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&amp;doi=10.17116%2fjnevro201511571112-116&amp;partnerID=40&amp;md5=d627b1d1e0674d0be3e6fa7af2c09a99\"\n     onclick=\"log_download('tsygan-trashkov-yakovleva-malkova-gracheva-kovalenko-vasiliev-characteristicsoftheregulationofneurotrophicmechanismsinischemicstroke-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&amp;doi=10.17116%2fjnevro201511571112-116&amp;partnerID=40&amp;md5=d627b1d1e0674d0be3e6fa7af2c09a99', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.17116/jnevro201511571112-116\"\n     onclick=\"log_download('tsygan-trashkov-yakovleva-malkova-gracheva-kovalenko-vasiliev-characteristicsoftheregulationofneurotrophicmechanismsinischemicstroke-2015', 'http://doi.org/10.17116/jnevro201511571112-116', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/tsygan-trashkov-yakovleva-malkova-gracheva-kovalenko-vasiliev-characteristicsoftheregulationofneurotrophicmechanismsinischemicstroke-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('tsygan-trashkov-yakovleva-malkova-gracheva-kovalenko-vasiliev-characteristicsoftheregulationofneurotrophicmechanismsinischemicstroke-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Tsygan2015112,\r\nauthor={Tsygan, N.V. and Trashkov, A.P. and Yakovleva, V.A. and Malkova, V.M. and Gracheva, E.V. and Kovalenko, A.L. and Vasiliev, A.G.},\r\ntitle={Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke},\r\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\r\nyear={2015},\r\nvolume={2015},\r\nnumber={7},\r\npages={112-116},\r\ndoi={10.17116/jnevro201511571112-116},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946123240&amp;doi=10.17116%2fjnevro201511571112-116&amp;partnerID=40&amp;md5=d627b1d1e0674d0be3e6fa7af2c09a99},\r\naffiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation; St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation; Institute of Toxicology of the Federal Medical-Biological Agency, St. Petersburg, Russian Federation},\r\nabstract={Objective. To explore the endogenous and pharmacological activation of neurotrophic mechanisms in a model of brain ischemic lesion in rats. Material and methods. The study was performed on 170 male albino rats (195-205 g). The model of ischemic stroke was accomplished by the electrocoagulation of the proximal segment of the left middle cerebral artery and simultaneous permanent ligation of the left common carotid artery. Results and conclusion. The evaluation of NSE, NO, VEGF, NGF levels in the brain cytoplasmic lysate and plasma showed the delayed activation of neurotrophic mechanisms in astrocytes accompanied by a decrease in delayed alteration of neurons. The use of cytoflavin in the treatment of stroke was accompanied by the earlier and more intense activation of neurotrophic mechanisms in astrocytes, delayed activation of neurotrophic mechanisms in endothelial cells, which promoted neuroprotection in acute ischemic stroke. © 2015, Media Sphera. All rights reserved.},\r\nauthor_keywords={Cytoflavin;  Endothelial dysfunction;  Ischemic stroke;  Multimodal cytoprotection;  Neurotrophic factors;  Neurotrophic mechanisms},\r\npublisher={Media Sphera},\r\nissn={19977298},\r\npubmed_id={26356524},\r\nlanguage={Russian},\r\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Objective. To explore the endogenous and pharmacological activation of neurotrophic mechanisms in a model of brain ischemic lesion in rats. Material and methods. The study was performed on 170 male albino rats (195-205 g). The model of ischemic stroke was accomplished by the electrocoagulation of the proximal segment of the left middle cerebral artery and simultaneous permanent ligation of the left common carotid artery. Results and conclusion. The evaluation of NSE, NO, VEGF, NGF levels in the brain cytoplasmic lysate and plasma showed the delayed activation of neurotrophic mechanisms in astrocytes accompanied by a decrease in delayed alteration of neurons. The use of cytoflavin in the treatment of stroke was accompanied by the earlier and more intense activation of neurotrophic mechanisms in astrocytes, delayed activation of neurotrophic mechanisms in endothelial cells, which promoted neuroprotection in acute ischemic stroke. © 2015, Media Sphera. All rights reserved.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"trashkov-panchenko-korablev-yurova-egormin-chernenko-gpopovich-tyndyk-etal-agedynamicsofangiogenesismarkersintransgenicher2neufbvnmammaryadenocarcinomapronemice-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&amp;partnerID=40&amp;md5=25700032627eb71d9f9c0243ffa43e26\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'trashkov-panchenko-korablev-yurova-egormin-chernenko-gpopovich-tyndyk-etal-agedynamicsofangiogenesismarkersintransgenicher2neufbvnmammaryadenocarcinomapronemice-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&amp;partnerID=40&amp;md5=25700032627eb71d9f9c0243ffa43e26', event);\">\n    Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Trashkov, A.; Panchenko, A.; Korablev, R.; Yurova, M.; Egormin, P.; Chernenko, N.; Gpopovich, I.; Tyndyk, M.; Verlov, N.; Artemenko, M.; Vasiliev, A.;  and Anisimov, V.\n</span>\n\n  \n\n</span>\n\n  <i>Voprosy Onkologii</i>, 61(4): 642-646.  2015.\n  <span class=\"note\">cited By 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&amp;partnerID=40&amp;md5=25700032627eb71d9f9c0243ffa43e26\"\n     onclick=\"log_download('trashkov-panchenko-korablev-yurova-egormin-chernenko-gpopovich-tyndyk-etal-agedynamicsofangiogenesismarkersintransgenicher2neufbvnmammaryadenocarcinomapronemice-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&amp;partnerID=40&amp;md5=25700032627eb71d9f9c0243ffa43e26', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/trashkov-panchenko-korablev-yurova-egormin-chernenko-gpopovich-tyndyk-etal-agedynamicsofangiogenesismarkersintransgenicher2neufbvnmammaryadenocarcinomapronemice-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('trashkov-panchenko-korablev-yurova-egormin-chernenko-gpopovich-tyndyk-etal-agedynamicsofangiogenesismarkersintransgenicher2neufbvnmammaryadenocarcinomapronemice-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Trashkov2015642,\r\nauthor={Trashkov, A.P. and Panchenko, A.V. and Korablev, R.V. and Yurova, M.N. and Egormin, P.A. and Chernenko, N.A. and Gpopovich, I. and Tyndyk, M.L. and Verlov, N.A. and Artemenko, M.R. and Vasiliev, A.G. and Anisimov, V.N.},\r\ntitle={Age dynamics of angiogenesis markers in transgenic HER-2/neu (FBV/N) mammary adenocarcinoma-prone mice},\r\njournal={Voprosy Onkologii},\r\nyear={2015},\r\nvolume={61},\r\nnumber={4},\r\npages={642-646},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84953873365&amp;partnerID=40&amp;md5=25700032627eb71d9f9c0243ffa43e26},\r\naffiliation={State Pediatric Medical University, Russian Federation; N.N.Petrov Research Institute of Oncology, St.-Petersburg, Russian Federation},\r\nabstract={Age-dependent angiogenesis intensity changes have been studied in transgenic HER-2/neu (FBV/N) mice characteristic of breast tumors&#x27; high incidence with hyperexpression of HER- 2/neu. Concentration of vascular endothelial growth factor, insulin-dependent growth factor 1, nitrogen monoxide, tissue plasminogen activator and type 1 plasminogen activator inhibitor were assessed by means of immune-enzyme assay. The results testify to angiogenesis processes activation side by side with aging and growth of the tumors. Maximum manifestation of these disturbances (growth factors&#x27; blood concentrations increase and endotheliocytes&#x27; functional activity inhibition) has been revealed in 6-month-oId mice during neoplasma maximum intensive and aggressive growth period.},\r\nauthor_keywords={Age-dependent changes;  Angiogenesis;  Biomodeling;  Breast tumors;  Hemostasis;  HER- 2/neu;  IGF-1;  PAI-1;  TPA;  VEGF},\r\npublisher={Izdatel&#x27;stvo Meditsina},\r\nissn={05073758},\r\ncoden={VOONA},\r\npubmed_id={26571837},\r\nlanguage={Russian},\r\nabbrev_source_title={Vopr. Onkol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Age-dependent angiogenesis intensity changes have been studied in transgenic HER-2/neu (FBV/N) mice characteristic of breast tumors' high incidence with hyperexpression of HER- 2/neu. Concentration of vascular endothelial growth factor, insulin-dependent growth factor 1, nitrogen monoxide, tissue plasminogen activator and type 1 plasminogen activator inhibitor were assessed by means of immune-enzyme assay. The results testify to angiogenesis processes activation side by side with aging and growth of the tumors. Maximum manifestation of these disturbances (growth factors' blood concentrations increase and endotheliocytes' functional activity inhibition) has been revealed in 6-month-oId mice during neoplasma maximum intensive and aggressive growth period.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"trashkov-vasiliev-kovalenko-tagirov-metabolictherapyofnephrolithiasisintwodifferentratmodelsofkidneydisease-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&amp;partnerID=40&amp;md5=84ca1147478becd454660d7e67dfab73\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'trashkov-vasiliev-kovalenko-tagirov-metabolictherapyofnephrolithiasisintwodifferentratmodelsofkidneydisease-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&amp;partnerID=40&amp;md5=84ca1147478becd454660d7e67dfab73', event);\">\n    Metabolic therapy of nephrolithiasis in two different rat models of kidney disease.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Trashkov, A.; Vasiliev, A.; Kovalenko, A.;  and Tagirov, N.\n</span>\n\n  \n\n</span>\n\n  <i>Eksperimental'naya i Klinicheskaya Farmakologiya</i>, 78(3): 17-21.  2015.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&amp;partnerID=40&amp;md5=84ca1147478becd454660d7e67dfab73\"\n     onclick=\"log_download('trashkov-vasiliev-kovalenko-tagirov-metabolictherapyofnephrolithiasisintwodifferentratmodelsofkidneydisease-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&amp;partnerID=40&amp;md5=84ca1147478becd454660d7e67dfab73', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Metabolic therapy of nephrolithiasis in two different rat models of kidney disease [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/trashkov-vasiliev-kovalenko-tagirov-metabolictherapyofnephrolithiasisintwodifferentratmodelsofkidneydisease-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('trashkov-vasiliev-kovalenko-tagirov-metabolictherapyofnephrolithiasisintwodifferentratmodelsofkidneydisease-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Trashkov201517,\r\nauthor={Trashkov, A.P. and Vasiliev, A.G. and Kovalenko, A.L. and Tagirov, N.S.},\r\ntitle={Metabolic therapy of nephrolithiasis in two different rat models of kidney disease},\r\njournal={Eksperimental&#x27;naya i Klinicheskaya Farmakologiya},\r\nyear={2015},\r\nvolume={78},\r\nnumber={3},\r\npages={17-21},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936061800&amp;partnerID=40&amp;md5=84ca1147478becd454660d7e67dfab73},\r\naffiliation={Saint-Petersburg State Pediatric Medical University, Russian Federation; Toxicological Institute of Federal Medical Biological Agency, Russian Federation},\r\nabstract={108 albino male rats were used in two experimental rat models reproducing urolithiasis for the assessment of metabolic drug medicine Remaxol nephroprotecti-ve effect upon the development of this disease. &quot;Ethyleneglycol&quot; model consisted of adding 1 % ethylene glycol solution in drinking water for 37 days and &quot;fructose-induced&quot; one-of adding 10 % fructose solution in drinking water for the same period. Therapy included a 10-day course of daily i.v. injections of Remaxol (14 ml/kg). Both experimental models were successful in producing urolithiasis with considerable disturbances in the structure and functioning of kidneys up to revealing microconcrement formation. The &quot;ethyleneglycol&quot; model proved to cause maximum changes while the &quot;Fructose-induced&quot; model-only moderate ones. Metabolic correction of these changes was successful in nephroprotection effectively normalizing kidney functions and the total protein concentration, eliminating hyperglycemia and reducing creatinine and urea blood plasma concentration in both rat experimental models.},\r\nauthor_keywords={Experimental urolithiasis models;  Metabolic medicines;  Nephroprotection;  Rats;  Remaxol;  Urolithiasis},\r\npublisher={Izdatel&#x27;stvo Meditsina},\r\nissn={08692092},\r\npubmed_id={26036006},\r\nlanguage={Russian},\r\nabbrev_source_title={Eksp. Klinicheskaya Farmakol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  108 albino male rats were used in two experimental rat models reproducing urolithiasis for the assessment of metabolic drug medicine Remaxol nephroprotecti-ve effect upon the development of this disease. \"Ethyleneglycol\" model consisted of adding 1 % ethylene glycol solution in drinking water for 37 days and \"fructose-induced\" one-of adding 10 % fructose solution in drinking water for the same period. Therapy included a 10-day course of daily i.v. injections of Remaxol (14 ml/kg). Both experimental models were successful in producing urolithiasis with considerable disturbances in the structure and functioning of kidneys up to revealing microconcrement formation. The \"ethyleneglycol\" model proved to cause maximum changes while the \"Fructose-induced\" model-only moderate ones. Metabolic correction of these changes was successful in nephroprotection effectively normalizing kidney functions and the total protein concentration, eliminating hyperglycemia and reducing creatinine and urea blood plasma concentration in both rat experimental models.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"anisimov-popovich-zabezhinski-egormin-yurova-semenchenko-tyndyk-panchenko-etal-sexdifferencesinaginglifespanandspontaneoustumorigenesisin129svmiceneonatallyexposedtometforminhttpwwwtandfonlinecomdoipdf104161153841012014973308-2015\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&amp;doi=10.4161%2f15384101.2014.973308&amp;partnerID=40&amp;md5=49a3af703f203dd6654be7b4c2fc0bb3\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'anisimov-popovich-zabezhinski-egormin-yurova-semenchenko-tyndyk-panchenko-etal-sexdifferencesinaginglifespanandspontaneoustumorigenesisin129svmiceneonatallyexposedtometforminhttpwwwtandfonlinecomdoipdf104161153841012014973308-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&amp;doi=10.4161%2f15384101.2014.973308&amp;partnerID=40&amp;md5=49a3af703f203dd6654be7b4c2fc0bb3', event);\">\n    Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973308.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Anisimov, V.; Popovich, I.; Zabezhinski, M.; Egormin, P.; Yurova, M.; Semenchenko, A.; Tyndyk, M.; Panchenko, A.; Trashkov, A.; Vasiliev, A.;  and Khaitsev, N.\n</span>\n\n  \n\n</span>\n\n  <i>Cell Cycle</i>, 14(1): 46-55.  2015.\n  <span class=\"note\">cited By 21</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&amp;doi=10.4161%2f15384101.2014.973308&amp;partnerID=40&amp;md5=49a3af703f203dd6654be7b4c2fc0bb3\"\n     onclick=\"log_download('anisimov-popovich-zabezhinski-egormin-yurova-semenchenko-tyndyk-panchenko-etal-sexdifferencesinaginglifespanandspontaneoustumorigenesisin129svmiceneonatallyexposedtometforminhttpwwwtandfonlinecomdoipdf104161153841012014973308-2015', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&amp;doi=10.4161%2f15384101.2014.973308&amp;partnerID=40&amp;md5=49a3af703f203dd6654be7b4c2fc0bb3', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973308 [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"http://doi.org/10.4161/15384101.2014.973308\"\n     onclick=\"log_download('anisimov-popovich-zabezhinski-egormin-yurova-semenchenko-tyndyk-panchenko-etal-sexdifferencesinaginglifespanandspontaneoustumorigenesisin129svmiceneonatallyexposedtometforminhttpwwwtandfonlinecomdoipdf104161153841012014973308-2015', 'http://doi.org/10.4161/15384101.2014.973308', event.ctrlKey)\"\n     class=\"bibbase doi link\">\n    <span>doi</span></a>\n  &nbsp;\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/anisimov-popovich-zabezhinski-egormin-yurova-semenchenko-tyndyk-panchenko-etal-sexdifferencesinaginglifespanandspontaneoustumorigenesisin129svmiceneonatallyexposedtometforminhttpwwwtandfonlinecomdoipdf104161153841012014973308-2015\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('anisimov-popovich-zabezhinski-egormin-yurova-semenchenko-tyndyk-panchenko-etal-sexdifferencesinaginglifespanandspontaneoustumorigenesisin129svmiceneonatallyexposedtometforminhttpwwwtandfonlinecomdoipdf104161153841012014973308-2015')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Anisimov201546,\r\nauthor={Anisimov, V. and Popovich, I.G. and Zabezhinski, M.A. and Egormin, P.A. and Yurova, M.N. and Semenchenko, A.V. and Tyndyk, M.L. and Panchenko, A.V. and Trashkov, A.P. and Vasiliev, A.G. and Khaitsev, N.V.},\r\ntitle={Sex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin http://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.973308},\r\njournal={Cell Cycle},\r\nyear={2015},\r\nvolume={14},\r\nnumber={1},\r\npages={46-55},\r\ndoi={10.4161/15384101.2014.973308},\r\nnote={cited By 21},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921884953&amp;doi=10.4161%2f15384101.2014.973308&amp;partnerID=40&amp;md5=49a3af703f203dd6654be7b4c2fc0bb3},\r\naffiliation={N.N. Petrov Research Institute of Oncology, St. Petersburg, Russian Federation; St. Petersburg State Pediatric Medical University, St. Petersburg, Russian Federation},\r\nabstract={The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of energy and metabolic homeostasis. We hypothesized that neonatal treatment with antidiabetic drug biguanide metformin would positively modify regulation of growth hormone - IGF-1 -insulin signaling pathway slowing down aging and improving cancer preventive patterns in rodents. To test this hypothesis male and female 129/Sv mice were s.c. injected with metformin (100 mg/kg) at the 3rd, 5th and 7th days after birth. Metformin-treated males consumed less food and water and their body weight was decreased as compared with control mice practically over their entire lifespan. There were no significant differences in age-related dynamics of food and water consumption in females and they were heavier than controls. The fraction of mice with regular estrous cycles decreased with age and demonstrated a tendency to decrease in the females neonatally treated with metformin. Neonatal exposure to metformin practically failed to change the extent of hormonal and metabolic parameters in blood serum of male and female mice. In males, neonatal metformin treatment significantly increased the mean life span (C20%, P &lt; 0.05) and slightly increased the maximum life span (C3.5%). In females, the mean life span and median in metformin-treated groups were slightly decreased (-9.1% and -13.8% respectively, P &gt; 0.05) in comparison to controls, whereas mean life span of last 10% survivors and maximum life span were the same as in controls. Almost half (45%) of control male mice and 71.8% male mice neonatally exposed to metformin survived up to 800 d of age, the same age was achieved by 54.3% of mice in control female group and 30% of metformin-treated females (P &lt; 0.03). Thus, neonatal metformin exposure slows down aging and prolongs lifespan in male but not in female mice. © 2015 Taylor &amp; Francis Group, LLC.},\r\nauthor_keywords={Biomarkers of aging;  Carcinogenesis;  Gender;  Life extension;  Metformin;  Mice;  Neonatal},\r\nfunding_details={Ministry of Education and Science of the Russian Federation11–04–003472},\r\n}</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The perinatal (prenatal and early neonatal) period is a critical stage for hypothalamic programming of sexual differentiation as well as for the development of energy and metabolic homeostasis. We hypothesized that neonatal treatment with antidiabetic drug biguanide metformin would positively modify regulation of growth hormone - IGF-1 -insulin signaling pathway slowing down aging and improving cancer preventive patterns in rodents. To test this hypothesis male and female 129/Sv mice were s.c. injected with metformin (100 mg/kg) at the 3rd, 5th and 7th days after birth. Metformin-treated males consumed less food and water and their body weight was decreased as compared with control mice practically over their entire lifespan. There were no significant differences in age-related dynamics of food and water consumption in females and they were heavier than controls. The fraction of mice with regular estrous cycles decreased with age and demonstrated a tendency to decrease in the females neonatally treated with metformin. Neonatal exposure to metformin practically failed to change the extent of hormonal and metabolic parameters in blood serum of male and female mice. In males, neonatal metformin treatment significantly increased the mean life span (C20%, P < 0.05) and slightly increased the maximum life span (C3.5%). In females, the mean life span and median in metformin-treated groups were slightly decreased (-9.1% and -13.8% respectively, P > 0.05) in comparison to controls, whereas mean life span of last 10% survivors and maximum life span were the same as in controls. Almost half (45%) of control male mice and 71.8% male mice neonatally exposed to metformin survived up to 800 d of age, the same age was achieved by 54.3% of mice in control female group and 30% of metformin-treated females (P < 0.03). Thus, neonatal metformin exposure slows down aging and prolongs lifespan in male but not in female mice. © 2015 Taylor & Francis Group, LLC.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2014\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2014')\"\n      onkeypress=\"toggleGroup('group_2014')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2014</span>\n      <span class=\"bibbase_group_count\">\n        \n        (1)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"tsygan-trashkov-pathogenicvariantsofbraininjuriesandpharmalogiccerebroprotectionperformedonthemodelofbrainconditionduringcardiovascularbypasssurgery-2014\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&amp;partnerID=40&amp;md5=4d3932101742b08acb0601cf554911b0\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'tsygan-trashkov-pathogenicvariantsofbraininjuriesandpharmalogiccerebroprotectionperformedonthemodelofbrainconditionduringcardiovascularbypasssurgery-2014', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&amp;partnerID=40&amp;md5=4d3932101742b08acb0601cf554911b0', event);\">\n    [Pathogenic variants of brain injuries and pharmalogic cerebroprotection performed on the model of brain condition during cardiovascular bypass surgery].\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Tsygan, N.;  and Trashkov, A.\n</span>\n\n  \n\n</span>\n\n  <i>Voenno-medit͡sinskiĭ zhurnal</i>, 335(10): 34-45.  2014.\n  <span class=\"note\">cited By 1</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&amp;partnerID=40&amp;md5=4d3932101742b08acb0601cf554911b0\"\n     onclick=\"log_download('tsygan-trashkov-pathogenicvariantsofbraininjuriesandpharmalogiccerebroprotectionperformedonthemodelofbrainconditionduringcardiovascularbypasssurgery-2014', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&amp;partnerID=40&amp;md5=4d3932101742b08acb0601cf554911b0', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"[Pathogenic variants of brain injuries and pharmalogic cerebroprotection performed on the model of brain condition during cardiovascular bypass surgery] [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/tsygan-trashkov-pathogenicvariantsofbraininjuriesandpharmalogiccerebroprotectionperformedonthemodelofbrainconditionduringcardiovascularbypasssurgery-2014\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('tsygan-trashkov-pathogenicvariantsofbraininjuriesandpharmalogiccerebroprotectionperformedonthemodelofbrainconditionduringcardiovascularbypasssurgery-2014')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Tsygan201434,\r\nauthor={Tsygan, N.V. and Trashkov, A.P.},\r\ntitle={[Pathogenic variants of brain injuries and pharmalogic cerebroprotection performed on the model of brain condition during cardiovascular bypass surgery]},\r\njournal={Voenno-medit͡sinskiĭ zhurnal},\r\nyear={2014},\r\nvolume={335},\r\nnumber={10},\r\npages={34-45},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84923569230&amp;partnerID=40&amp;md5=4d3932101742b08acb0601cf554911b0},\r\nabstract={Developed and approved a pathogenic grounded experimental model of brain condition during cardiovascular bypass surgery. Undertaken in Wistar rats research allowed to evaluate in detail effectiveness and safety of protracted cerebroprotective treatment. Advantages of this model are researches in laboratory animals with the aim to research condition of nerve tissue, not intensive procedures and consequently high reproducibility and possibility of complex evaluation of changes at every stage of research. Results of neurons, neuroglia and activation of neurotrophic mechanisms prove that simulation of brain condition during cardiovascular bypass surgery is accompanied with acute and delayed brain injuries. Use of Cytoflavin under pharmalogic cerebroprotection had prolonged multimodal and neuroprotactive effect, leading to improvement of neurotrophic protection from the first days.},\r\nissn={00269050},\r\npubmed_id={25532310},\r\nlanguage={Russian},\r\nabbrev_source_title={Voen Med Zh},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Developed and approved a pathogenic grounded experimental model of brain condition during cardiovascular bypass surgery. Undertaken in Wistar rats research allowed to evaluate in detail effectiveness and safety of protracted cerebroprotective treatment. Advantages of this model are researches in laboratory animals with the aim to research condition of nerve tissue, not intensive procedures and consequently high reproducibility and possibility of complex evaluation of changes at every stage of research. Results of neurons, neuroglia and activation of neurotrophic mechanisms prove that simulation of brain condition during cardiovascular bypass surgery is accompanied with acute and delayed brain injuries. Use of Cytoflavin under pharmalogic cerebroprotection had prolonged multimodal and neuroprotactive effect, leading to improvement of neurotrophic protection from the first days.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2013\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2013')\"\n      onkeypress=\"toggleGroup('group_2013')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2013</span>\n      <span class=\"bibbase_group_count\">\n        \n        (3)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"tsygan-trashkov-brainfunctionalstateandcytoprotectivepotentialinmodelofacutecerebralhypoxiaexperimentalresearch-2013\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&amp;partnerID=40&amp;md5=29ed65140755fb5ce34683dfae316e97\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'tsygan-trashkov-brainfunctionalstateandcytoprotectivepotentialinmodelofacutecerebralhypoxiaexperimentalresearch-2013', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&amp;partnerID=40&amp;md5=29ed65140755fb5ce34683dfae316e97', event);\">\n    [Brain functional state and cytoprotective potential in model of acute cerebral hypoxia (experimental research)].\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Tsygan, N.;  and Trashkov, A.\n</span>\n\n  \n\n</span>\n\n  <i>Patologicheskaia fiziologiia i èksperimental'naia terapiia</i>, (4): 10-16.  2013.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&amp;partnerID=40&amp;md5=29ed65140755fb5ce34683dfae316e97\"\n     onclick=\"log_download('tsygan-trashkov-brainfunctionalstateandcytoprotectivepotentialinmodelofacutecerebralhypoxiaexperimentalresearch-2013', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&amp;partnerID=40&amp;md5=29ed65140755fb5ce34683dfae316e97', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"[Brain functional state and cytoprotective potential in model of acute cerebral hypoxia (experimental research)]. [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/tsygan-trashkov-brainfunctionalstateandcytoprotectivepotentialinmodelofacutecerebralhypoxiaexperimentalresearch-2013\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('tsygan-trashkov-brainfunctionalstateandcytoprotectivepotentialinmodelofacutecerebralhypoxiaexperimentalresearch-2013')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Tsygan201310,\r\nauthor={Tsygan, N.V. and Trashkov, A.P.},\r\ntitle={[Brain functional state and cytoprotective potential in model of acute cerebral hypoxia (experimental research)].},\r\njournal={Patologicheskaia fiziologiia i èksperimental&#x27;naia terapiia},\r\nyear={2013},\r\nnumber={4},\r\npages={10-16},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899742214&amp;partnerID=40&amp;md5=29ed65140755fb5ce34683dfae316e97},\r\nabstract={The functional state of the brain and the potential of pharmacologic cytoprotection after an acute cerebral hypoxia were studied. The experiment involved 186 adult male rats. The rats in experimental groups underwent acute thromboembolism of the right carotid artery. The functional state of the brain and the efficacy and safety of the Cytoflavin complex cytoprotective drug treatment had been analyzed over the 10 days following the thromboembolism. A neurological examination was accomplished daily, the serum levels of NSE, GFAP, S100beta and brain cytolysate levels of NSE were measured on the 1st, 3rd, 10th day. The NSE brain cytolysate level went up on the 1st day and the NSE serum level was up on the 3rd day following the thromboembolism, which may have indicated an acute delayed alteration of neurons and an increase of the blood-brain barrier permeability on the 3rd day after the thromboemboIism. Neuroglial biomarkers went up on the 1st (GFAP), 3rd and 10th (S100beta) day, which indicated an acute delayed alteration and/or activation of glial cells. Therefore, the applied experimental model promotes acute delayed alteration of neurons and neuroglia with a possible activation of the latter. The Cytoflavin proved to have a cytoprotective effect on neurons and to diminish the alteration and/or activation of glial cells over the observed period after the acute thromboembolism of the carotid artery.},\r\ncorrespondence_address1={Tsygan, N.V.},\r\nissn={00312991},\r\npubmed_id={24640767},\r\nlanguage={Russian},\r\nabbrev_source_title={Patol Fiziol Eksp Ter},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The functional state of the brain and the potential of pharmacologic cytoprotection after an acute cerebral hypoxia were studied. The experiment involved 186 adult male rats. The rats in experimental groups underwent acute thromboembolism of the right carotid artery. The functional state of the brain and the efficacy and safety of the Cytoflavin complex cytoprotective drug treatment had been analyzed over the 10 days following the thromboembolism. A neurological examination was accomplished daily, the serum levels of NSE, GFAP, S100beta and brain cytolysate levels of NSE were measured on the 1st, 3rd, 10th day. The NSE brain cytolysate level went up on the 1st day and the NSE serum level was up on the 3rd day following the thromboembolism, which may have indicated an acute delayed alteration of neurons and an increase of the blood-brain barrier permeability on the 3rd day after the thromboemboIism. Neuroglial biomarkers went up on the 1st (GFAP), 3rd and 10th (S100beta) day, which indicated an acute delayed alteration and/or activation of glial cells. Therefore, the applied experimental model promotes acute delayed alteration of neurons and neuroglia with a possible activation of the latter. The Cytoflavin proved to have a cytoprotective effect on neurons and to diminish the alteration and/or activation of glial cells over the observed period after the acute thromboembolism of the carotid artery.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"odinak-shamre-chudinovskikh-goncharenko-tsygan-stagesofformationanddevelopmentofthenationalmilitaryneurologyandpsychiatry-2013\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&amp;partnerID=40&amp;md5=4c2de30409d0313ab295d6591e18b4c3\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'odinak-shamre-chudinovskikh-goncharenko-tsygan-stagesofformationanddevelopmentofthenationalmilitaryneurologyandpsychiatry-2013', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&amp;partnerID=40&amp;md5=4c2de30409d0313ab295d6591e18b4c3', event);\">\n    [Stages of formation and development of the national military neurology and psychiatry].\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Odinak, M.; Shamreǐ, V.; Chudinovskikh, A.; Goncharenko, A.;  and Tsygan, N.\n</span>\n\n  \n\n</span>\n\n  <i>Voenno-meditcombining double inverted brevesinskiǐ zhurnal</i>, 334(12): 59-67.  2013.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&amp;partnerID=40&amp;md5=4c2de30409d0313ab295d6591e18b4c3\"\n     onclick=\"log_download('odinak-shamre-chudinovskikh-goncharenko-tsygan-stagesofformationanddevelopmentofthenationalmilitaryneurologyandpsychiatry-2013', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&amp;partnerID=40&amp;md5=4c2de30409d0313ab295d6591e18b4c3', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"[Stages of formation and development of the national military neurology and psychiatry]. [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/odinak-shamre-chudinovskikh-goncharenko-tsygan-stagesofformationanddevelopmentofthenationalmilitaryneurologyandpsychiatry-2013\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('odinak-shamre-chudinovskikh-goncharenko-tsygan-stagesofformationanddevelopmentofthenationalmilitaryneurologyandpsychiatry-2013')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Odinak201359,\r\nauthor={Odinak, M.M. and Shamreǐ, V.K. and Chudinovskikh, A.G. and Goncharenko, A.I. and Tsygan, N.V.},\r\ntitle={[Stages of formation and development of the national military neurology and psychiatry].},\r\njournal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},\r\nyear={2013},\r\nvolume={334},\r\nnumber={12},\r\npages={59-67},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901481094&amp;partnerID=40&amp;md5=4c2de30409d0313ab295d6591e18b4c3},\r\nabstract={The article is devoted to the stages of formation and development of military neurology and psychiatry in Russia. Scholars of anxiety and mental disorders department of the Medical and Surgical Academy (Military Medical) made great contribution to development of scientific and organizational peculiarities of these medical disciplines and many other allied studies. Authors analyze the contribution of military psychiatrists and neurologists to the modern concept of mental care delivery in peace and wartime, research focus ares and prospects of its development.},\r\ncorrespondence_address1={Odinak, M.M.},\r\nissn={00269050},\r\npubmed_id={24738283},\r\nlanguage={Russian},\r\nabbrev_source_title={Voen Med Zh},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The article is devoted to the stages of formation and development of military neurology and psychiatry in Russia. Scholars of anxiety and mental disorders department of the Medical and Surgical Academy (Military Medical) made great contribution to development of scientific and organizational peculiarities of these medical disciplines and many other allied studies. Authors analyze the contribution of military psychiatrists and neurologists to the modern concept of mental care delivery in peace and wartime, research focus ares and prospects of its development.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"odinak-yanishevski-tsygan-golokhvastov-vozniuk-trufanov-theuseofsuccinatesforthecorrectionofmetabolicdisordersinthepenumbrainpatientswithstroke-2013\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&amp;partnerID=40&amp;md5=8188c3acced00cf4b96d213bf98cdab0\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'odinak-yanishevski-tsygan-golokhvastov-vozniuk-trufanov-theuseofsuccinatesforthecorrectionofmetabolicdisordersinthepenumbrainpatientswithstroke-2013', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&amp;partnerID=40&amp;md5=8188c3acced00cf4b96d213bf98cdab0', event);\">\n    The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Odinak, M.; Yanishevskiǐ, S.; Tsygan, N.; Golokhvastov, S.; Vozniuk, I.;  and Trufanov, A.\n</span>\n\n  \n\n</span>\n\n  <i>Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova</i>, 2013(12): 55-60.  2013.\n  <span class=\"note\">cited By 4</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&amp;partnerID=40&amp;md5=8188c3acced00cf4b96d213bf98cdab0\"\n     onclick=\"log_download('odinak-yanishevski-tsygan-golokhvastov-vozniuk-trufanov-theuseofsuccinatesforthecorrectionofmetabolicdisordersinthepenumbrainpatientswithstroke-2013', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&amp;partnerID=40&amp;md5=8188c3acced00cf4b96d213bf98cdab0', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/odinak-yanishevski-tsygan-golokhvastov-vozniuk-trufanov-theuseofsuccinatesforthecorrectionofmetabolicdisordersinthepenumbrainpatientswithstroke-2013\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('odinak-yanishevski-tsygan-golokhvastov-vozniuk-trufanov-theuseofsuccinatesforthecorrectionofmetabolicdisordersinthepenumbrainpatientswithstroke-2013')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Odinak201355,\r\nauthor={Odinak, M.M. and Yanishevskiǐ, S.N. and Tsygan, N.V. and Golokhvastov, S.Y. and Vozniuk, I.A. and Trufanov, A.G.},\r\ntitle={The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke},\r\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\r\nyear={2013},\r\nvolume={2013},\r\nnumber={12},\r\npages={55-60},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899726349&amp;partnerID=40&amp;md5=8188c3acced00cf4b96d213bf98cdab0},\r\naffiliation={Kirov Military Medical Academy, St. Petersburg, Russian Federation},\r\nabstract={The aim of the study was to determine the quantitative content and correlation between metabolites in the core ischemic zone, the ischemic penumbra and the intact tissue of the opposite hemisphere in the acute stage of ischemic stroke using MR-spectroscopy. We studied 72 patients, including 37 patients (the main group) treated with the antioxidant mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate) in addition to standard therapy and 35 patients who received standard therapy only. The severity of stroke was assessed using the NIHSS. The Barthel index and Rankin scale were used to evaluate functional outcome in the 30th day, hydrogen MR-spectroscopy was used twice: in the first 24 h from disease onset and in the 5th day. Mexidol used in dose 500 mg intravenously during 14 days reduced significantly the content of lactate (p=0.002) and inositol (p=0.005) in the cells compared to the control group that enhanced the restoration of the balance between aerobic and anaerobic mechanisms of oxidation and positively influenced on the rehabilitation of patients. Positive correlations between the content of lactate in the ischemic penumbra and NIHSS scores (r=0.5786; p=0.049) and the negative correlation between the content of lactate in the ischemic penumbra and the degree of functional restoration assessed by the Barthel index (r= -0.6305; p=0.028) were found. These findings support the evidence for the interaction between the disturbance of glucose metabolism in conditions of hypoxia and the degree of nervous tissue damage.},\r\nauthor_keywords={Antioxidants;  Ischemic stroke;  Magnetic resonance spectroscopy;  Mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate)},\r\nissn={19977298},\r\npubmed_id={24430036},\r\nlanguage={English},\r\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The aim of the study was to determine the quantitative content and correlation between metabolites in the core ischemic zone, the ischemic penumbra and the intact tissue of the opposite hemisphere in the acute stage of ischemic stroke using MR-spectroscopy. We studied 72 patients, including 37 patients (the main group) treated with the antioxidant mexidol (2-ethyl-6-methyl-3-hydroxypiridine succinate) in addition to standard therapy and 35 patients who received standard therapy only. The severity of stroke was assessed using the NIHSS. The Barthel index and Rankin scale were used to evaluate functional outcome in the 30th day, hydrogen MR-spectroscopy was used twice: in the first 24 h from disease onset and in the 5th day. Mexidol used in dose 500 mg intravenously during 14 days reduced significantly the content of lactate (p=0.002) and inositol (p=0.005) in the cells compared to the control group that enhanced the restoration of the balance between aerobic and anaerobic mechanisms of oxidation and positively influenced on the rehabilitation of patients. Positive correlations between the content of lactate in the ischemic penumbra and NIHSS scores (r=0.5786; p=0.049) and the negative correlation between the content of lactate in the ischemic penumbra and the degree of functional restoration assessed by the Barthel index (r= -0.6305; p=0.028) were found. These findings support the evidence for the interaction between the disturbance of glucose metabolism in conditions of hypoxia and the degree of nervous tissue damage.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2012\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2012')\"\n      onkeypress=\"toggleGroup('group_2012')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2012</span>\n      <span class=\"bibbase_group_count\">\n        \n        (2)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"odinak-neznanov-chudinovskih-tsygan-vladimirmikhailovitchbekhterevthefounderoftheclinicalneuropsychiatry-2012\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&amp;partnerID=40&amp;md5=68d718e3c50f74bbb80b865028640312\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'odinak-neznanov-chudinovskih-tsygan-vladimirmikhailovitchbekhterevthefounderoftheclinicalneuropsychiatry-2012', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&amp;partnerID=40&amp;md5=68d718e3c50f74bbb80b865028640312', event);\">\n    Vladimir Mikhailovitch Bekhterev - The founder of the clinical neuropsychiatry.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Odinak, M.; Neznanov, N.; Chudinovskih, A.;  and Tsygan, N.\n</span>\n\n  \n\n</span>\n\n  <i>Vestnik Rossiiskoi Akademii Meditsinskikh Nauk</i>, (8): 34-39.  2012.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&amp;partnerID=40&amp;md5=68d718e3c50f74bbb80b865028640312\"\n     onclick=\"log_download('odinak-neznanov-chudinovskih-tsygan-vladimirmikhailovitchbekhterevthefounderoftheclinicalneuropsychiatry-2012', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&amp;partnerID=40&amp;md5=68d718e3c50f74bbb80b865028640312', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Vladimir Mikhailovitch Bekhterev - The founder of the clinical neuropsychiatry [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/odinak-neznanov-chudinovskih-tsygan-vladimirmikhailovitchbekhterevthefounderoftheclinicalneuropsychiatry-2012\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('odinak-neznanov-chudinovskih-tsygan-vladimirmikhailovitchbekhterevthefounderoftheclinicalneuropsychiatry-2012')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Odinak201234,\r\nauthor={Odinak, M.M. and Neznanov, N.G. and Chudinovskih, A.G. and Tsygan, N.V.},\r\ntitle={Vladimir Mikhailovitch Bekhterev - The founder of the clinical neuropsychiatry},\r\njournal={Vestnik Rossiiskoi Akademii Meditsinskikh Nauk},\r\nyear={2012},\r\nnumber={8},\r\npages={34-39},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84872432264&amp;partnerID=40&amp;md5=68d718e3c50f74bbb80b865028640312},\r\naffiliation={Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg, Russian Federation; Saint Petersburg Neuropsychiatry Research Institute n.a. V.M. Bekhterev, Russian Federation},\r\nabstract={The article presents main milestones in the career of Vladimir Mikhailovitch Bekhterev. The research in anatomy and physiology of the brain performed by V.M. Bekhterev gave original data of worldwide priority. V.M. Bekhterev significantly improved methodology of neurological examination and differential diagnosis in clinical neuropsychiatry. The scientific heritage of V.M. Bekhterev proves his outstanding role in establishment and development of the neuropsychiatry.},\r\nauthor_keywords={Clinical neuropsychiatry;  History of neurology;  History of psychiatry;  V.M. Bekhterev},\r\ncorrespondence_address1={Odinak, M.M.; Military Medical Academy n.a. S.M. Kirov, Saint-Petersburg, Russian Federation},\r\nissn={08696047},\r\npubmed_id={23166987},\r\nlanguage={Russian},\r\nabbrev_source_title={Vestn. Ross. Akad. Med. Nauk},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The article presents main milestones in the career of Vladimir Mikhailovitch Bekhterev. The research in anatomy and physiology of the brain performed by V.M. Bekhterev gave original data of worldwide priority. V.M. Bekhterev significantly improved methodology of neurological examination and differential diagnosis in clinical neuropsychiatry. The scientific heritage of V.M. Bekhterev proves his outstanding role in establishment and development of the neuropsychiatry.\n</div>\n\n\n</div>\n\n\n  <div class=\"bibbase_paper\" id=\"tsygan-thealgorithmofthecomprehensiveassessmentofthebrainduringcardiacsurgerywithcardiopulmonarybypass-2012\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&amp;partnerID=40&amp;md5=f5cb15bc2be8c2ca5685a1ed11bce224\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'tsygan-thealgorithmofthecomprehensiveassessmentofthebrainduringcardiacsurgerywithcardiopulmonarybypass-2012', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&amp;partnerID=40&amp;md5=f5cb15bc2be8c2ca5685a1ed11bce224', event);\">\n    [The algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass].\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Tsygan, N.\n</span>\n\n  \n\n</span>\n\n  <i>Voenno-meditcombining double inverted brevesinskiǐ zhurnal</i>, 333(6): 42-46.  2012.\n  <span class=\"note\">cited By 4</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&amp;partnerID=40&amp;md5=f5cb15bc2be8c2ca5685a1ed11bce224\"\n     onclick=\"log_download('tsygan-thealgorithmofthecomprehensiveassessmentofthebrainduringcardiacsurgerywithcardiopulmonarybypass-2012', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&amp;partnerID=40&amp;md5=f5cb15bc2be8c2ca5685a1ed11bce224', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"[The algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass]. [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/tsygan-thealgorithmofthecomprehensiveassessmentofthebrainduringcardiacsurgerywithcardiopulmonarybypass-2012\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('tsygan-thealgorithmofthecomprehensiveassessmentofthebrainduringcardiacsurgerywithcardiopulmonarybypass-2012')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Tsygan201242,\r\nauthor={Tsygan, N.V.},\r\ntitle={[The algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass].},\r\njournal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},\r\nyear={2012},\r\nvolume={333},\r\nnumber={6},\r\npages={42-46},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866028428&amp;partnerID=40&amp;md5=f5cb15bc2be8c2ca5685a1ed11bce224},\r\nabstract={The article presents the algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass, based on contemporary concept of intraoperative brain damage pathogenesis. The algorithm includes clinical, laboratory and instrumental diagnostic procedures in the perioperative period. The article shows the prospects of the use of the algorithm for optimizing neuroprotection and outcomes in cardiac surgery and acute stroke.},\r\ncorrespondence_address1={Tsygan, N.V.},\r\nissn={00269050},\r\npubmed_id={22888701},\r\nlanguage={Russian},\r\nabbrev_source_title={Voen Med Zh},\r\ndocument_type={Review},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  The article presents the algorithm of the comprehensive assessment of the brain during cardiac surgery with cardiopulmonary bypass, based on contemporary concept of intraoperative brain damage pathogenesis. The algorithm includes clinical, laboratory and instrumental diagnostic procedures in the perioperative period. The article shows the prospects of the use of the algorithm for optimizing neuroprotection and outcomes in cardiac surgery and acute stroke.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2011\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2011')\"\n      onkeypress=\"toggleGroup('group_2011')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2011</span>\n      <span class=\"bibbase_group_count\">\n        \n        (1)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"khubulava-ivchenko-pavin-kravchuk-iurchenko-ivashchenko-didenko-lukianov-etal-experienceofleftventricularassistdeviceincorasbridgetorecoveryimplantationinpatientswithendstagecongestiveheartfailure-2011\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&amp;partnerID=40&amp;md5=e62a131bbea78ac2407104486e0adcf2\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'khubulava-ivchenko-pavin-kravchuk-iurchenko-ivashchenko-didenko-lukianov-etal-experienceofleftventricularassistdeviceincorasbridgetorecoveryimplantationinpatientswithendstagecongestiveheartfailure-2011', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&amp;partnerID=40&amp;md5=e62a131bbea78ac2407104486e0adcf2', event);\">\n    [Experience of left ventricular assist device \"Incor\" as \"bridge to recovery\" implantation in patients with end stage congestive heart failure].\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Khubulava, G.; Ivchenko, E.; Paǐvin, A.; Kravchuk, V.; Iurchenko, D.; Ivashchenko, A.; Didenko, M.; Luk'ianov, N.; Peleshok, A.; Tsygan, N.; Liubimov, A.; Naumov, A.; Shorokhov, K.; Sukharev, A.; Kniazev, E.;  and Porembskaia, I.\n</span>\n\n  \n\n</span>\n\n  <i>Voenno-meditcombining double inverted brevesinskiǐ zhurnal</i>, 332(11): 29-35.  2011.\n  <span class=\"note\">cited By 0</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&amp;partnerID=40&amp;md5=e62a131bbea78ac2407104486e0adcf2\"\n     onclick=\"log_download('khubulava-ivchenko-pavin-kravchuk-iurchenko-ivashchenko-didenko-lukianov-etal-experienceofleftventricularassistdeviceincorasbridgetorecoveryimplantationinpatientswithendstagecongestiveheartfailure-2011', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&amp;partnerID=40&amp;md5=e62a131bbea78ac2407104486e0adcf2', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"[Experience of left ventricular assist device &quot;Incor&quot; as &quot;bridge to recovery&quot; implantation in patients with end stage congestive heart failure]. [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/khubulava-ivchenko-pavin-kravchuk-iurchenko-ivashchenko-didenko-lukianov-etal-experienceofleftventricularassistdeviceincorasbridgetorecoveryimplantationinpatientswithendstagecongestiveheartfailure-2011\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('khubulava-ivchenko-pavin-kravchuk-iurchenko-ivashchenko-didenko-lukianov-etal-experienceofleftventricularassistdeviceincorasbridgetorecoveryimplantationinpatientswithendstagecongestiveheartfailure-2011')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Khubulava201129,\r\nauthor={Khubulava, G.G. and Ivchenko, E.V. and Paǐvin, A.A. and Kravchuk, V.N. and Iurchenko, D.L. and Ivashchenko, A.I. and Didenko, M.V. and Luk&#x27;ianov, N.G. and Peleshok, A.S. and Tsygan, N.V. and Liubimov, A.I. and Naumov, A.B. and Shorokhov, K.H. and Sukharev, A.E. and Kniazev, E.A. and Porembskaia, I.A.},\r\ntitle={[Experience of left ventricular assist device &quot;Incor&quot; as &quot;bridge to recovery&quot; implantation in patients with end stage congestive heart failure].},\r\njournal={Voenno-medit{combining double inverted breve}sinskiǐ zhurnal},\r\nyear={2011},\r\nvolume={332},\r\nnumber={11},\r\npages={29-35},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84857776627&amp;partnerID=40&amp;md5=e62a131bbea78ac2407104486e0adcf2},\r\nabstract={Left ventricular assist device &quot;Incor&quot; (&quot;Berlinhear&quot;, Germany) implantation experience in patient with ischemic cardiomiopathy and severe congestive heart failure is presented. Left ventricular assist device implantation was followed by coronary artery bypass grafting simultaneously. Total assist time was 211 days. Complications developed during assisting time are shown. After Left ventricular assist device explantation three chamber pacemaker was implanted as cardiac resynchronization therapy. Left ventricular end diastolic size decreased (from 78 to 70 mm), ejection fraction increased (from 19 to 35%) during assist time.},\r\ncorrespondence_address1={Khubulava, G.G.},\r\nissn={00269050},\r\npubmed_id={22329169},\r\nlanguage={Russian},\r\nabbrev_source_title={Voen Med Zh},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  Left ventricular assist device \"Incor\" (\"Berlinhear\", Germany) implantation experience in patient with ischemic cardiomiopathy and severe congestive heart failure is presented. Left ventricular assist device implantation was followed by coronary artery bypass grafting simultaneously. Total assist time was 211 days. Complications developed during assisting time are shown. After Left ventricular assist device explantation three chamber pacemaker was implanted as cardiac resynchronization therapy. Left ventricular end diastolic size decreased (from 78 to 70 mm), ejection fraction increased (from 19 to 35%) during assist time.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_2010\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_2010')\"\n      onkeypress=\"toggleGroup('group_2010')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>2010</span>\n      <span class=\"bibbase_group_count\">\n        \n        (1)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"odinak-skvortsova-vosniuk-rumiantseva-stakhovskaya-klocheva-novikova-yanishevsky-etal-efficacyofcytoflavininpatientsintheacuteischemicstroke-2010\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&amp;partnerID=40&amp;md5=3feeb5bc96137ec07e6c36691bccf7b4\"\n     onclick=\"return trackOutboundLink('publications', 'click', 'odinak-skvortsova-vosniuk-rumiantseva-stakhovskaya-klocheva-novikova-yanishevsky-etal-efficacyofcytoflavininpatientsintheacuteischemicstroke-2010', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&amp;partnerID=40&amp;md5=3feeb5bc96137ec07e6c36691bccf7b4', event);\">\n    Efficacy of cytoflavin in patients in the acute ischemic stroke.\n  </a>\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  Odinak, M.; Skvortsova, V.; Vosniuk, I.; Rumiantseva, S.; Stakhovskaya, L.; Klocheva, E.; Novikova, L.; Yanishevsky, S.; Golokhvastov, S.;  and Tsygan, N.\n</span>\n\n  \n\n</span>\n\n  <i>Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova</i>, 110(12): 29-36.  2010.\n  <span class=\"note\">cited By 3</span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n  <a href=\"https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&amp;partnerID=40&amp;md5=3feeb5bc96137ec07e6c36691bccf7b4\"\n     onclick=\"log_download('odinak-skvortsova-vosniuk-rumiantseva-stakhovskaya-klocheva-novikova-yanishevsky-etal-efficacyofcytoflavininpatientsintheacuteischemicstroke-2010', 'https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&amp;partnerID=40&amp;md5=3feeb5bc96137ec07e6c36691bccf7b4', event.ctrlKey, event)\">\n    <img src=\"//bibbase.org/img/filetypes/link.svg\"\n\t     alt=\"Efficacy of cytoflavin in patients in the acute ischemic stroke [link]\"\n       title=\"Paper\"\n\t     class=\"bibbase_icon\"\n         ><span class=\"bibbase_icon_text\">Paper</span></a>\n  &nbsp;\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/odinak-skvortsova-vosniuk-rumiantseva-stakhovskaya-klocheva-novikova-yanishevsky-etal-efficacyofcytoflavininpatientsintheacuteischemicstroke-2010\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n  &nbsp;\n  <a class=\"bibbase_abstract_link bibbase link\"\n     href=\"#\"\n     onclick=\"showAbstract(event); return false;\">\n    abstract <i class=\"fa fa-caret-down\"></i></a>\n  \n\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('odinak-skvortsova-vosniuk-rumiantseva-stakhovskaya-klocheva-novikova-yanishevsky-etal-efficacyofcytoflavininpatientsintheacuteischemicstroke-2010')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\">@ARTICLE{Odinak201029,\r\nauthor={Odinak, M.M. and Skvortsova, V.I. and Vosniuk, I.A. and Rumiantseva, S.A. and Stakhovskaya, L.V. and Klocheva, E.G. and Novikova, L.B. and Yanishevsky, S.N. and Golokhvastov, S.Y. and Tsygan, N.V.},\r\ntitle={Efficacy of cytoflavin in patients in the acute ischemic stroke},\r\njournal={Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova},\r\nyear={2010},\r\nvolume={110},\r\nnumber={12},\r\npages={29-36},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-79953267693&amp;partnerID=40&amp;md5=3feeb5bc96137ec07e6c36691bccf7b4},\r\nabstract={We present the results of a multicenter study on efficacy of cytoflavin in the treatment of patients with acute ischemic stroke. Seventy patients (41 of the main group and 29 of the control group) were enrolled in the study. All patients received basic therapy aimed at improving systemic hemodynamics, rheological blood properties and at the prevention of stroke complications. Patients of the main group were treated with cytoflavin as follows: days 1-10 - 20 ml (in 400 ml of the 0,9% NaCl solution) twice a day intravenously in drops; days 11-35 - 850 mg twice a day. We assessed the dynamics of restoration of lost functions (NIHSS, the Rankin scale, the Barthel index) and volumes of ischemic lesion (MRI T1-, T2-, diffusion-weighted images). Results of the study on patients of the control group were supplemented with literature data about 306 patients studied using clinical scales and 40 patients studied with MRI. We revealed a trend towards an effect of cytoflavin on the preservation of brain matter in the acute phase of stroke. Cytoflavin reduced the neurological deficit and improved activities of daily living in patients that may be explained by the less brain damage.},\r\nauthor_keywords={Brain infarction volume;  Cytoflavin, antioxidant;  Ischemic stroke;  Magnetic resonance tomography},\r\ncorrespondence_address1={Stakhovskaya, L. V.email: nabi@orc.ru},\r\nissn={19977298},\r\npubmed_id={21311484},\r\nlanguage={English},\r\nabbrev_source_title={Zh. Nevrologii Psihiatrii im. S.S. Korsakova},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n</pre>\n</div>\n\n\n<div class=\"well well-small bibbase\" data-type=\"abstract\"\n     style=\"display:none\">\n  We present the results of a multicenter study on efficacy of cytoflavin in the treatment of patients with acute ischemic stroke. Seventy patients (41 of the main group and 29 of the control group) were enrolled in the study. All patients received basic therapy aimed at improving systemic hemodynamics, rheological blood properties and at the prevention of stroke complications. Patients of the main group were treated with cytoflavin as follows: days 1-10 - 20 ml (in 400 ml of the 0,9% NaCl solution) twice a day intravenously in drops; days 11-35 - 850 mg twice a day. We assessed the dynamics of restoration of lost functions (NIHSS, the Rankin scale, the Barthel index) and volumes of ischemic lesion (MRI T1-, T2-, diffusion-weighted images). Results of the study on patients of the control group were supplemented with literature data about 306 patients studied using clinical scales and 40 patients studied with MRI. We revealed a trend towards an effect of cytoflavin on the preservation of brain matter in the acute phase of stroke. Cytoflavin reduced the neurological deficit and improved activities of daily living in patients that may be explained by the less brain damage.\n</div>\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n  <div class=\"bibbase_group_whole\" id=\"group_undefined\">\n    <div class=\"bibbase_group\"\n      onclick=\"toggleGroup('group_undefined')\"\n      onkeypress=\"toggleGroup('group_undefined')\"\n      tabindex=\"0\">\n      <i class=\"fa fa-angle-down bibbase_group_head_icon\"></i>&nbsp;\n      <span>undefined</span>\n      <span class=\"bibbase_group_count\">\n        \n        (1)\n        \n      </span>\n    </div>\n    <div class=\"bibbase_group_body\">\n      \n  \n  <div class=\"bibbase_paper\" id=\"anonymous-\">\n  <span class=\"bibbase_paper_titleauthoryear\">\n\n  \n  <span class=\"bibbase_paper_title\">\n  \n  \n  \n  .\n  \n  \n  \n</span>\n\n  <span class=\"bibbase_paper_author\">\n  \n</span>\n\n  \n\n</span>\n\n  .  .\n  <span class=\"note\"></span>\n\n<span class=\"bibbase_note\"></span>\n\n<br class=\"bibbase_paper_content\"/>\n\n<span class=\"bibbase_paper_content dontprint\">\n\n  \n\n  \n\n  \n  <a href=\"//bibbase.org/network/publication/anonymous-\"\n     class=\"bibbase bibbase_page link\">link</a>\n  &nbsp;\n  \n\n  <a href=\"#\"\n     onclick=\"showBib(event); return false;\"\n     class=\"bibbase bibtex link\">bibtex\n    <i class=\"fa fa-caret-down\"></i></a>\n\n  \n\n  \n  &nbsp;\n  <span class=\"bibbase_stats_paper\" style=\"color: #777;\">\n    <span>9 downloads</span>\n  </span>\n  \n\n  <!-- <a class=\"bibbase read link hidden\" -->\n  <!--    href=\"javascript:toggleRead('anonymous-')\" -->\n  <!--    title=\"Marking this paper as read adds it to your library on BibBase.\" -->\n  <!--    > -->\n  <!--   <i class=\"fa fa-check\"></i>&nbsp; -->\n  <!--   <span>mark as read</span> -->\n  <!-- </a> -->\n\n  &nbsp;\n  \n  \n\n</span>\n\n<div class=\"well well-small bibbase\" data-type=\"bibtex\"\n     style=\"display:none\">\n  <pre style=\"white-space: pre-wrap;\"></pre>\n</div>\n\n\n\n</div>\n\n\n\n\n\n    </div>\n  </div>\n\n\n\n\n  </div>\n\n\n  <!-- Modal -->\n\n  <!-- <iframe id=\"bibbase_network_frame\" -->\n  <!--         src=\"//bibbase.org/network/control\" -->\n  <!--         style=\"display: none;\"> -->\n  <!-- </iframe> -->\n\n</div>\n"}; document.write(bibbase_data.data);