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\n \n 2018\n \n \n (3)\n \n \n

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\n \n\n \n \n \n \n \n \n Conformational Transitions of Silk Fibroin in Solutions under the Action of Ultrasound.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Russian Journal of Applied Chemistry, 91(7): 1193-1197. 2018.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Conformational$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n A Comparative Study of Solutions of Silk Fibroin in 1-Butyl-3-methylimidazolium Chloride and Acetate.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Russian Journal of Applied Chemistry, 91(4): 647-652. 2018.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"A$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Modular interactions of proteins in the perimembrane signaling complexes.\n \n \n \n \n\n\n \n Orlov, Y.\n\n\n \n\n\n\n Tsitologiya, 60(7): 503-509. 2018.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Modular$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Orlov2018503,\r\nauthor={Orlov, Yu.N.},\r\ntitle={Modular interactions of proteins in the perimembrane signaling complexes},\r\njournal={Tsitologiya},\r\nyear={2018},\r\nvolume={60},\r\nnumber={7},\r\npages={503-509},\r\ndoi={10.31116/tsitol.2018.07.03},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064591161&doi=10.31116%2ftsitol.2018.07.03&partnerID=40&md5=383343d71366617ef1550b7f5824c696},\r\naffiliation={B. P. Konstantinov Petersburg Nuclear Physics Institute, National Research Centre Kurchatov Institute, Gatchina, Leningrad Region, 188300, Russian Federation; Peter the Great St. Petersburg Polytechnic University, Department of biophysics, St. Petersburg, 195251, Russian Federation},\r\nabstract={The review considers molecular mechanisms that assure the assembly of protein complexes that control cell signaling. Such complexes often localize near the surface of cell membranes, and therefore we will call them «perimembrane» in the sense that their formation either directly or indirectly depends on the structure of the membrane surface. Among the proteins involved in the control of signal transduction, amphitropic proteins, whose activity depends on localization, are of particular interest: they perform their functions if bound to membranes and are not active if they are in the cytosol. This feature points to the selective interaction of amphitropic proteins with membranes. In this regard, it is assumed that the intracellular membranes have a unique structural code («lipid code»), which can be «read» by amphyrotropic proteins. Studies that have long been carried out in this field cover a wide range of issues related not only to the structure of membranes or amphitropic proteins, but also to the metabolism of lipids in membranes. Although many questions remain unclear, it is believed that the perimembrane mechanisms controlling signal transduction should include two factors — membrane lipid asymmetry and lipid-protein specific interactions. © 2018 Sankt Peterburg. All rights reserved.},\r\nauthor_keywords={Amphitropic proteins;  Lipid asymmetry;  Modular domains;  Phosphoinositides;  Signal transduction;  Unstructured proteins},\r\ncorrespondence_address1={Orlov, Yu.N.; B. P. Konstantinov Petersburg Nuclear Physics Institute, National Research Centre Kurchatov InstituteRussian Federation; email: y.orlov@rambler.ru},\r\npublisher={Sankt Peterburg},\r\nissn={00413771},\r\ncoden={TSITA},\r\nlanguage={Russian},\r\nabbrev_source_title={Tsitologiya},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 2017\n \n \n (4)\n \n \n

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\n \n\n \n \n \n \n \n \n Identification of brain proteins BASP1 and GAP-43 in mouse oocytes and zygotes.\n \n \n \n \n\n\n \n Zakharova, F.; and Zakharov, V.\n\n\n \n\n\n\n Russian Journal of Developmental Biology, 48(3): 159-168. 2017.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Identification$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Zakharova2017159,\r\nauthor={Zakharova, F.M. and Zakharov, V.V.},\r\ntitle={Identification of brain proteins BASP1 and GAP-43 in mouse oocytes and zygotes},\r\njournal={Russian Journal of Developmental Biology},\r\nyear={2017},\r\nvolume={48},\r\nnumber={3},\r\npages={159-168},\r\ndoi={10.1134/S1062360417030110},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020301491&doi=10.1134%2fS1062360417030110&partnerID=40&md5=675114c4c21a31ee6f43a3211c430580},\r\naffiliation={Institute of Experimental Medicine, St. Petersburg, 197376, Russian Federation; St. Petersburg State University, St. Petersburg, 199034, Russian Federation; Konstantinov Petersburg Nuclear Physics Institute, National Research Center Kurchatov Institute, Gatchina, Leningrad oblast  188300, Russian Federation; Peter the Great St. Petersburg Polytechnic University, St. Petersburg, 195251, Russian Federation; Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, 199004, Russian Federation},\r\nabstract={The similarity between the calcium-activated signaling systems of oocytes and neuronal axon terminals has prompted us to test whether BASP1 and GAP-43 proteins, highly expressed in brain neurons, are present in oocytes. Using immunocytochemical techniques combined with confocal microscopy, we have for the first time demonstrated that both BASP1 and GAP-43 are present in mouse metaphase II (MII) oocytes and zygotes. BASP1 is localized to the plasma membrane and actin cortex of MII oocytes, which is similar to BASP1 distribution in neurons and other cell types. GAP-43 is generally regarded as a postmitotic membrane marker of nerve cells; however, GAP-43 in MII oocytes is associated with microtubules of the meiotic spindle. GAP-43 is also colocalized with γ-tubulin at the spindle poles (centrosomes) and at the discrete microtubule- organizing centers in the cytoplasm. The antibodies to Ser41-phosphorylated form of GAP-43 allowed for demonstration that GAP-43 in oocytes is subject to phosphorylation by protein kinase C. The presence of BASP1 and GAP-43 in oocytes is also confirmed by electrophoresis and western blotting. Microinjection of BASP1 (but not GAP-43) into the cytoplasm of mouse MII oocytes induces their exit from metaphase II arrest followed by parthenogenetic embryo development. This suggests putative BASP1 involvement in fertilization-induced oocyte activation, presumably, through regulation of local concentration of polyphosphoinositides in the plasma membrane. Recently it was found that GAP-43 is associated with centrosomes in asymmetrically dividing neuronal progenitors, which is similar to the localization of GAP-43 at the meiotic spindle and centrosomes in oocytes. Therefore we suggest that GAP-43 may be involved in regulation of spindle orientation and oocyte polarity. © 2017, Pleiades Publishing, Inc.},\r\nauthor_keywords={actin cortex;  BASP1;  centrosomes;  GAP-43;  meiotic spindle;  mouse oocytes;  oocyte activation;  protein kinase C},\r\ncorrespondence_address1={Zakharova, F.M.; Institute of Experimental MedicineRussian Federation; email: fzakharova@mail.ru},\r\npublisher={Maik Nauka Publishing / Springer SBM},\r\nissn={10623604},\r\nlanguage={English},\r\nabbrev_source_title={Russ. J. Dev. Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Aggregation by lectins as an approach for exosome isolation from biological fluids: Validation for proteomic studies.\n \n \n \n \n\n\n \n Shtam, T.; Burdakov, V.; Landa, S.; Naryzhny, S.; Bairamukov, V.; Malek, A.; Orlov, Y.; and Filatov, M.\n\n\n \n\n\n\n Cell and Tissue Biology, 11(2): 172-179. 2017.\n cited By 4\n\n\n\n
\n\n\n\n \n \n $\"Aggregation$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Shtam2017172,\r\nauthor={Shtam, T.A. and Burdakov, V.S. and Landa, S.B. and Naryzhny, S.N. and Bairamukov, V.Y. and Malek, A.V. and Orlov, Y.N. and Filatov, M.V.},\r\ntitle={Aggregation by lectins as an approach for exosome isolation from biological fluids: Validation for proteomic studies},\r\njournal={Cell and Tissue Biology},\r\nyear={2017},\r\nvolume={11},\r\nnumber={2},\r\npages={172-179},\r\ndoi={10.1134/S1990519X17020043},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018499633&doi=10.1134%2fS1990519X17020043&partnerID=40&md5=f439cee2262ea4552aa9c299648a59e1},\r\naffiliation={National Research Centre “Kurchatov Institute” B.P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, 188300, Russian Federation; Peter the Great Polytechnic University, St. Petersburg, 195251, Russian Federation; Petrov Institute of Oncology, Ministry of Healthcare of the Russian Federation, St. Petersburg, 197758, Russian Federation; Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, 119121, Russian Federation},\r\nabstract={Exosomes, a special type of microparticles produced by cells, are currently of considerable interest for researchers. The term “exosomes” denotes extracellular vesicles of less than 120 nm in size derived from intracellular multivesicular bodies. Multiple studies that address the distinctive features of exosome structure and biochemical composition in various pathological states imply the possibility of development of novel diagnostic techniques based on the detection of changes in the pool of proteins and nucleic acids transported by exosomes. However, methods for isolation and investigation of exosomes are rather difficult to develop because of a small size of these vesicles. A novel approach for preparative-scale isolation of exosomes based on the phenomenon of binding and aggregation of these particles in the presence of lectins has been put forward in the present study. The method developed is relatively cost-effective, allows for the isolation of exosomes from various biological fluids, and has been validated for the subsequent analysis of the protein composition of the exosomes in view of the possible clinical applications. The validation showed that the sedimentation of lectin-aggregated exosomes is a suitable approach for the isolation of these microvesicles from the complete conditioned culture medium in a research-laboratory setup. © 2017, Pleiades Publishing, Ltd.},\r\nauthor_keywords={exosomes;  lectins;  methods of exosome isolation},\r\ncorrespondence_address1={Filatov, M.V.; National Research Centre “Kurchatov Institute” B.P. Konstantinov Petersburg Nuclear Physics InstituteRussian Federation; email: fil_53@mail.ru},\r\npublisher={Maik Nauka-Interperiodica Publishing},\r\nissn={1990519X},\r\nlanguage={English},\r\nabbrev_source_title={Cell Tissue Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n The impact of high salt consumption on the renal metabolism of NAP-22 and MARCKS, major protein kinase C substrates, in spontaneously hypertensive rats.\n \n \n \n \n\n\n \n Klyueva, N.; Rudenko, E.; Aldekeeva, A.; Plekhanov, A.; Korneva, N.; and Petrova, E.\n\n\n \n\n\n\n Arterial Hypertension (Russian Federation), 23(6): 574-580. 2017.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Klyueva2017574,\r\nauthor={Klyueva, N.Z. and Rudenko, E.D. and Aldekeeva, A.S. and Plekhanov, A.Y. and Korneva, N.A. and Petrova, E.I.},\r\ntitle={The impact of high salt consumption on the renal metabolism of NAP-22 and MARCKS, major protein kinase C substrates, in spontaneously hypertensive rats},\r\njournal={Arterial Hypertension (Russian Federation)},\r\nyear={2017},\r\nvolume={23},\r\nnumber={6},\r\npages={574-580},\r\ndoi={10.18705/1607-419X-2017-23-6-574-580},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041110186&doi=10.18705%2f1607-419X-2017-23-6-574-580&partnerID=40&md5=857bca81359840a7fc7bb096c679d5ec},\r\naffiliation={Pavlov Institute of Physiology, 6 Makarova emb., Saint-Petersburg, 199034, Russian Federation; Institute for Analytical Instrumentation, St Petersburg, Russian Federation; Petersburg Nuclear Physics Institute, Gatchina, Russian Federation},\r\nabstract={Objective. To investigate changes in NAP-22 messenger RNA (mRNA) expression level and the level of NAP-22 protein, as well as the level of MARCKS protein in kidney cells cytosole in spontaneously hypertensive rats after long-term high salt consumption which is a dietary factor of arterial hypertension (HTN). Design and methods. We evaluated SHR and WKY male rats before and after 10-day consumption of 1 % NaCl instead of drinking water. NAP-22 mRNA level was estimated using real time polymerase chain reaction (PCR), and the content of NAP-22 and MARCKS proteins was evaluated by dot immunoblotting or electerophoresis with subsequent immunoblotting. Results. In spontaneously hypurtensive rats, the renal level of NAP-22 mRNA expression was significantly increased as compared with WKY group. High NaCl consumption definitely diminished NAP-22 mRNA expression in the both rat lines, however, its level was still higher in hypertensive rats than in normotensive rats. The NAP-22 protein level decreased, too. Similar changes were observed in the level of MARCKS protein in renal tissue. Conclusions. Unlike the long-term exogenous calcium deficiency, the salt load leads to the decrease of both RNA expression and the content in major protein kinase C (PK C) substrate proteins (NAP-22 and MARCKS). This indicates a potential change in the functioning of renal PK C system with an increased consumption of NaCl.},\r\nauthor_keywords={Kidney;  MARCKS;  NAP-22;  Salt charge;  Shr and wky rat lines;  Spontaneous hypertension},\r\ncorrespondence_address1={Klyueva, N.Z.; Pavlov Institute of Physiology, 6 Makarova emb., Russian Federation; email: natklueva@mail.ru},\r\npublisher={All-Russian Public Organization Antihypertensive League},\r\nissn={1607419X},\r\nlanguage={Russian},\r\nabbrev_source_title={Arter. Hypertens.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Metabolism of the major protein kinase C substrate NAP-22 in hippocampus and parietal cortex of spontaneously-hypertensive rats: The impact of dietary salt load.\n \n \n \n \n\n\n \n Klyueva, N.; Rudenko, E.; Aldekeeva, A.; Plekhanov, A.; Chernyshev, Y.; and Antonova, O.\n\n\n \n\n\n\n Arterial Hypertension (Russian Federation), 23(4): 325-331. 2017.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"Metabolism$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Klyueva2017325,\r\nauthor={Klyueva, N.Z. and Rudenko, E.D. and Aldekeeva, A.S. and Plekhanov, A.Y. and Chernyshev, Y.I. and Antonova, O.S.},\r\ntitle={Metabolism of the major protein kinase C substrate NAP-22 in hippocampus and parietal cortex of spontaneously-hypertensive rats: The impact of dietary salt load},\r\njournal={Arterial Hypertension (Russian Federation)},\r\nyear={2017},\r\nvolume={23},\r\nnumber={4},\r\npages={325-331},\r\ndoi={10.18705/1607-419X-2017-23-4-325-331},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033699852&doi=10.18705%2f1607-419X-2017-23-4-325-331&partnerID=40&md5=0c6a3df11e6413442d76199c96345f00},\r\naffiliation={Pavlov Institute of Physiology, 6 Makarova emb., St Petersburg, 199034, Russian Federation; Institute for Analytical Instrumentation, St Petersburg, Russian Federation; St Petersburg Nuclear Physics Institute, Gatchina, Russian Federation},\r\nabstract={Objective: To assess the changes in NAP-22 messenger ribonucleic acid (mRNA) expression level as well as NAP-22 protein content in hippocampus and in parietal cortex of spontaneously-hypertensive rats after longterm dietary salt load (nutritional factor of the arterial hypertension, HTN). design and methods: We examined SHR and WKY male rats before and after 1 % NaCl consumption instead of drinking water. NAP-22 mRNA level was estimated using real time PCR, and the content of NAP-22 protein and its isoforms was evaluated by electerophoresis with subsequent immunoblotting. Results: In spontaneously-hypertensive rats, NAP-22 mRNA expression in parietal cortex significantly decreased after the salt load, the decrease was more profound in parietal cortex than in hippocampus and even more expressed in the normotensive control. After the salt load, NAP-22 protein level in parietal cortex decreased more in SHR rats than in the normotensive rats. conclusions: Although both salt load and dietary calcium deficiency induce similar changes in blood pressure, intracellular mechanisms of developing HTN are different. Intracellular signaling cascades involved in the salt load model need further investigation.},\r\nauthor_keywords={Hippocampus;  NAP-22;  Parietal cortex;  Salt load;  SHR rats;  Spontaneous hypertension},\r\ncorrespondence_address1={Klyueva, N.Z.; Pavlov Institute of Physiology, 6 Makarova emb., Russian Federation; email: natklueva@mail.ru},\r\npublisher={All-Russian Public Organization Antihypertensive League},\r\nissn={1607419X},\r\nlanguage={Russian},\r\nabbrev_source_title={Arter. Hypertens.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 2016\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n A Group of Weakly Bound to Neurons Extracellular Metallopeptidases (NEMPs).\n \n \n \n \n\n\n \n Kropotova, E.; and Mosevitsky, M.\n\n\n \n\n\n\n Neurochemical Research, 41(10): 2666-2674. 2016.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"A$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kropotova20162666,\r\nauthor={Kropotova, E.S. and Mosevitsky, M.I.},\r\ntitle={A Group of Weakly Bound to Neurons Extracellular Metallopeptidases (NEMPs)},\r\njournal={Neurochemical Research},\r\nyear={2016},\r\nvolume={41},\r\nnumber={10},\r\npages={2666-2674},\r\ndoi={10.1007/s11064-016-1979-9},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84976254630&doi=10.1007%2fs11064-016-1979-9&partnerID=40&md5=64ec5eda3d4d9d0fad9977304a5a4eb6},\r\naffiliation={Division of Molecular Biophysics, Petersburg Nuclear Physics Institute, Gatchina, 188300, Russian Federation; Institute of Macromolecular Compounds, Russian Academy of Sciences, Sanct Petersburg, 199034, Russian Federation},\r\nabstract={We have found that isolated from mammalian brain (rat, bovine) axonal endings (synaptosomes) degrade peptides of different composition. With the use of low concentration of non ionic detergent Triton X-100 (0.05–0.1 %) four low specific metallopeptidases were detached from synaptosomes. These peptidases were named Neuronal EctoMetalloPeptidases (NEMPs). Using specially designed test-peptides they were characterized as: carboxypeptidase (NEMP1), aminopeptidase (NEMP2) and endopeptidases NEMP3 and NEMP4. NEMPs are true peptidases (oligopeptidases), because they are able efficiently degrade peptides containing less than 40 amino acid residues. Specific properties of some NEMPs were revealed. NEMP1 is a small protein (molecular mass of about 10 kDa), which tends to dynamic oligomerization. NEMP3 needs activation. Some amino acids activate this enzyme. As far as we know, these properties were not ascribed to the known similarly localized peptidases. A possible physiological function of low specific NEMPs is participation in control of wide range of neuropeptides secreted in the synaptic cleft. However, NEMPs also due to their low specificity can destroy introduced in brain therapeutic peptides. The data obtained in this study open new opportunities for the protection of synthetic therapeutic peptides in brain and, possibly, in other tissues. © 2016, Springer Science+Business Media New York.},\r\nauthor_keywords={Axonal ends;  Extracellular peptidases;  Neuropeptides;  Protection of therapeutic peptides;  Synaptosomes},\r\ncorrespondence_address1={Mosevitsky, M.I.; Institute of Macromolecular Compounds, Russian Academy of SciencesRussian Federation; email: m_mosev@mail.ru},\r\npublisher={Springer New York LLC},\r\nissn={03643190},\r\ncoden={NERED},\r\npubmed_id={27350576},\r\nlanguage={English},\r\nabbrev_source_title={Neurochem. Res.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n High-order oligomers of intrinsically disordered brain proteins BASP1 and GAP-43 preserve the structural disorder.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n FEBS Journal, 283(8): 1550-1569. 2016.\n cited By 8\n\n\n\n
\n\n\n\n \n \n $\"High-order$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n Brain acid-soluble protein-1 (BASP1) and growth-associated protein-43 (GAP-43) are presynaptic membrane proteins participating in axon guidance, neuroregeneration and synaptic plasticity. They are presumed to sequester phosphatidylinositol-4,5-bisphosphate (PIP2) in lipid rafts. Previously we have shown that the proteins form heterogeneously sized oligomers in the presence of anionic phospholipids or SDS at submicellar concentration. BASP1 and GAP-43 are intrinsically disordered proteins (IDPs). In light of this, we investigated the structure of their oligomers. Using partial cross-linking of the oligomers with glutaraldehyde, the aggregation numbers of BASP1 and GAP-43 were estimated as 10-14 and 6-7 monomer subunits, respectively. The cross-linking pattern indicated that the subunits are circularly arranged. The circular dichroism (CD) spectra of the monomers were characteristic of coil-like IDPs showing unordered structure with a high population of polyproline-II conformation. The oligomerization was accompanied by a minor CD spectral change attributable to formation of a small amount of α-helix. The number of residues in the α-helical conformation was estimated as 13 in BASP1 and 18 in GAP-43. However, the overall structure of the oligomers remained disordered, indicating a high degree of 'fuzziness'. This was confirmed by measuring the hydrodynamic dimensions of the oligomers using polyacrylamide gradient gel electrophoresis and size-exclusion chromatography, and by assaying their sensitivity to proteolytic digestion. There is evidence that the observed α-helical folding occurs within the basic effector domains, which are presumably tethered together via anionic molecules of SDS or PIP2. We conclude that BASP1 and GAP-43 oligomers preserve a mostly disordered structure, which may be of great importance for their function in PIP2 signaling pathway. BASP1 and GAP-43 are presynaptic membrane proteins which are intrinsically disordered. They form regular oligomers in the presence of anionic phospholipids or SDS. The overall structure of the oligomers proved to be disordered as in 'fuzzy complexes'. The oligomerization is accompanied by a minor folding attributable to formation of a small amount of α-helix, probably within the basic effector domains. © 2016 Federation of European Biochemical Societies.\n

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\n \n\n \n \n \n \n \n \n Phosphoinositide-dependent perimembrane mechanisms of regulating cellular processes.\n \n \n \n \n\n\n \n Orlov, Y.\n\n\n \n\n\n\n Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 9(3): 145-160. 2015.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Phosphoinositide-dependent$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Orlov2015145,\r\nauthor={Orlov, Y.N.},\r\ntitle={Phosphoinositide-dependent perimembrane mechanisms of regulating cellular processes},\r\njournal={Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology},\r\nyear={2015},\r\nvolume={9},\r\nnumber={3},\r\npages={145-160},\r\ndoi={10.1134/S1990747815020166},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84939202719&doi=10.1134%2fS1990747815020166&partnerID=40&md5=82d6d9ad7571dd795a9637f53b6bb2c4},\r\naffiliation={St. Petersburg State Polytechnic University, ul. Polytekhnicheskaya 29, St. Petersburg, 195251, Russian Federation; St. Petersburg Nuclear Physics Institute, NRC “Kurchatov Institute”, Orlova Roshcha, Gatchina, Leningrad oblast, 188300, Russian Federation},\r\nabstract={Phosphoinositides are minor phospholipids of cytosolic membrane surface involved in the regulation of vital cellular processes, including membrane trafficking, cytoskeletal dynamics and cell signaling. This regulation lies in their ability to control the subcellular localization and activity of different cytosolic (peripheral) effector proteins bearing phosphoinositide binding domains. However, the detailed molecular mechanisms by which phosphoinositides (and probably other phospholipids) may participate in the regulation of cellular functions remain the subject of debate. This review discusses the general features of the functioning of phosphoinositide system as an organizer and integrator of intracellular events. © 2015, Pleiades Publishing, Ltd.},\r\nauthor_keywords={intracellular signaling;  lipid metabolism;  membrane traffic;  phosphoinositides},\r\ncorrespondence_address1={Orlov, Y.N.; St. Petersburg State Polytechnic University, ul. Polytekhnicheskaya 29, Russian Federation},\r\npublisher={Maik Nauka-Interperiodica Publishing},\r\nissn={19907478},\r\nlanguage={English},\r\nabbrev_source_title={Biochem. (Moscow) Suppl. Ser. A Membr. Cell. Bio.},\r\ndocument_type={Review},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n BASP1 – an Axon Terminal Protein Forming Amyloid-Like Oligomers.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Neuroscience and Behavioral Physiology, 45(5): 523-527. 2015.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"BASP1$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Effects of dipole modifiers on channel-forming activity of amyloid and amyloid-like peptides in lipid bilayers.\n \n \n \n \n\n\n \n Efimova, S.; Zakharov, V.; and Ostroumova, O.\n\n\n \n\n\n\n Cell and Tissue Biology, 9(3): 250-259. 2015.\n cited By 4\n\n\n\n
\n\n\n\n \n \n $\"Effects$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Efimova2015250,\r\nauthor={Efimova, S.S. and Zakharov, V.V. and Ostroumova, O.S.},\r\ntitle={Effects of dipole modifiers on channel-forming activity of amyloid and amyloid-like peptides in lipid bilayers},\r\njournal={Cell and Tissue Biology},\r\nyear={2015},\r\nvolume={9},\r\nnumber={3},\r\npages={250-259},\r\ndoi={10.1134/S1990519X15030049},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935024724&doi=10.1134%2fS1990519X15030049&partnerID=40&md5=7dcfb32e25abc1eed89e0900c8a54477},\r\naffiliation={Institute of Cytology, Russian Academy of Sciences, Tikhoretsky pr. 4, St. Petersburg, 194064, Russian Federation; B.P. Konstantinov Petersburg Institute of Nuclear Physics, National Reseach Centre “Kurchatov Institute”, Gatchina, Leningrad oblast, 188300, Russian Federation; St. Petersburg State Polytechnic University, ul. Politekhnicheskaya 29, St. Petersburg, 195251, Russian Federation},\r\nabstract={The steady-state transmembrane current induced by amyloid and amyloid-like peptides in the model membranes has been studied. It is shown that the addition of dipole modifier phloretin to membrane bathing solutions resulted in an increase in the multichannel activity of peptides, such as fragment 25–35 of the amyloid β-peptide, fragment 25–35 of the amyloid β-peptide with an amino acid substitution at position 35, fragment 106–126 of the human prion protein, and the amyloid-like peptides myr-BASP1(1–13), myr-BASP1(1–19), and GAP-43(1–40). It has been shown that the effect of phloretin was not a result of variation in the membrane dipole potential during the adsorption of this modifier. Using different after fragments of amyloid β-peptide, presenilin, and prion protein, as well as the proteins BASP1 and GAP-43 and their fragments, we arrived at the conclusion that increase in the steady-state peptide-induced transmembrane current after addition of phloretin is determined by electrostatic interaction between a positively charged channel-forming agent and a negatively charged dipole modifier. Electron microscopy data have demonstrated that the degree of peptide oligomerization increases as a result of interaction with phloretin. © 2015, Pleiades Publishing, Ltd.},\r\nauthor_keywords={amyloidogenic peptides;  bilayer lipid membranes;  dipole modifiers;  membrane dipole potential},\r\nfunding_details={Russian Foundation for Basic Research14-04-31738},\r\ncorrespondence_address1={Efimova, S.S.; Institute of Cytology, Russian Academy of Sciences, Tikhoretsky pr. 4, Russian Federation},\r\npublisher={Maik Nauka-Interperiodica Publishing},\r\nissn={1990519X},\r\nlanguage={English},\r\nabbrev_source_title={Cell Tissue Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Phosphoinositide-dependent perimembrane mechanisms of regulating cellular processes.\n \n \n \n \n\n\n \n Orlov, Y.\n\n\n \n\n\n\n Biologicheskie Membrany, 32(3): 151-167. 2015.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Phosphoinositide-dependent$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Orlov2015151,\r\nauthor={Orlov, Yu.N.},\r\ntitle={Phosphoinositide-dependent perimembrane mechanisms of regulating cellular processes},\r\njournal={Biologicheskie Membrany},\r\nyear={2015},\r\nvolume={32},\r\nnumber={3},\r\npages={151-167},\r\ndoi={10.7868/S0233475515030068},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84945373766&doi=10.7868%2fS0233475515030068&partnerID=40&md5=e6596545f3346ab7da2415fac64795b4},\r\naffiliation={St. Petersburg Nuclear Physics Institute, NRC Kurchatov Institute, Orlova Roshcha, Gatchina, Leningrad oblast, 188300, Russian Federation; St. Petersburg State Polytechnic University, ul. Polytekhnicheskaya, 29, St. Petersburg, 195251, Russian Federation},\r\nabstract={Phosphoinositides are minor phospholipids of cytosolic membrane surface involved in the regulation of vital cellular processes, including membrane trafficking, cytoskeletal dynamics and cell signaling. This regulation lies in their ability to control the subcellular localization and activity of different cytosolic (peripheral) effector proteins bearing phosphoinositide binding domains. However, the detailed molecular mechanisms by which phosphoinositides (and probably other phospholipids) may participate in the regulation of cellular functions remain the subject of debate. This review discusses the general features of the functioning of phosphoinositide system as an organizer and integrator of intracellular events.},\r\nauthor_keywords={Intracellular signaling;  Lipid metabolism;  Membrane traffic;  Phosphoinositides},\r\ncorrespondence_address1={Orlov, Yu.N.; St. Petersburg Nuclear Physics Institute, NRC Kurchatov InstituteRussian Federation},\r\npublisher={Russian Academy of Sciences},\r\nissn={02334755},\r\nlanguage={Russian},\r\nabbrev_source_title={Biol. Membr.},\r\ndocument_type={Review},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n The influence of dipole modifiers on the channel-forming activity of amyloid and amyloid-like peptides in lipid bilayers.\n \n \n \n \n\n\n \n Efimova, S.; Zakharov, V.; and Ostroumova, O.\n\n\n \n\n\n\n Tsitologiya, 57(2): 144-152. 2015.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Efimova2015144,\r\nauthor={Efimova, S.S. and Zakharov, V.V. and Ostroumova, O.S.},\r\ntitle={The influence of dipole modifiers on the channel-forming activity of amyloid and amyloid-like peptides in lipid bilayers},\r\njournal={Tsitologiya},\r\nyear={2015},\r\nvolume={57},\r\nnumber={2},\r\npages={144-152},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84936156704&partnerID=40&md5=2983969d6459462712b1f5c78b6f3574},\r\naffiliation={Institute of Cytology RAS, St. Petersburg, Russian Federation; National Research Centre, NRC Kurchatov Institute, Gatchina, Russian Federation; St. Petersburg State Polytechnical University, Russian Federation},\r\nabstract={We have studied the steady-state transmembrane current induced by amyloid and amyloid-like peptides in lipid bilayers in the presence of dipole modifiers. It has been shown that the addition of dipole modifier, phlore-tin, to the membrane bathing solutions leads to an increase in the multichannel activity of amyloid β-peptide fragment 25-35, [Gly35]-amyloid β-peptide fragment 25-35, prion protein fragment 106-126 and amyloid-like peptides myr-BASP1 (1-13), myr-BASP1(1-19) and GAP-43(1-40). We have found that the effect of phloretin is not the result of dipole potential changes due to adsorption of this modifier on the membrane. Using the various fragments of amyloid β-peptide, presenilin, prion protein and neuronal proteins BASP1 and GAP-43 allowes to conclude that the steady-state peptide-induced transmembrane current in the case of addition of phloretin is due to the electrostatic interaction between the positively charged channel-forming agents and negatively charged dipole modifier. The results obtained by electron microscopy have demonstrated that this interaction increases degree of peptide oligomerization.},\r\nauthor_keywords={Amyloidogenic peptides;  Bilayer lipid membranes;  Dipole modifiers;  Membrane dipole potential},\r\npublisher={Maik Nauka Publishing / Springer SBM},\r\nissn={00413771},\r\ncoden={TSITA},\r\npubmed_id={26035972},\r\nlanguage={Russian},\r\nabbrev_source_title={Tsitologiya},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 2014\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n Altered expression of multiple genes involved in retinoic acid biosynthesis in human colorectal cancer.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Pathology and Oncology Research, 20(3): 707-717. 2014.\n cited By 14\n\n\n\n
\n\n\n\n \n \n $\"Altered$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Possible function of the ribT gene of Bacillus subtilis: Theoretical prediction, cloning, and expression.\n \n \n \n \n\n\n \n Yakimov, A.; Seregina, T.; Kholodnyak, A.; Kreneva, R.; Mironov, A.; Perumov, D.; and Timkovskii, A.\n\n\n \n\n\n\n Acta Naturae, 6(22): 106-109. 2014.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"Possible$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Yakimov2014106,\r\nauthor={Yakimov, A.P. and Seregina, T.A. and Kholodnyak, A.A. and Kreneva, R.A. and Mironov, A.S. and Perumov, D.A. and Timkovskii, A.L.},\r\ntitle={Possible function of the ribT gene of Bacillus subtilis: Theoretical prediction, cloning, and expression},\r\njournal={Acta Naturae},\r\nyear={2014},\r\nvolume={6},\r\nnumber={22},\r\npages={106-109},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908394416&partnerID=40&md5=e9574ffa58abf486552d26a2043ec902},\r\naffiliation={B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center Kurchatov Institute, Orlova Roshcha, Gatchina, Leningrad Region, 188300, Russian Federation; St. Petersburg State Polytechnical University, Polytechnicheskaya Str., 29, St. Petersburg, 195251, Russian Federation; State Research Institute of Genetics and Selection of Industrial Microorganisms, 1st Dorozhnyi Proezd, 1, Moscow, 117545, Russian Federation},\r\nabstract={The complete decipherment of the functions and interactions of the elements of the riboflavin biosynthesis operon (rib operon) of Bacillus subtilis are necessary for the development of superproducers of this important vitamin. The function of its terminal ribT gene has not been established to date. In this work, a search for homologs of the hypothetical amino acid sequence of the gene product through databases, as well as an analysis of the homolgs, was performed; the distribution of secondary structure elements was theoretically predicted; and the tertiary structure of the RibT protein was proposed. The ribT gene nucleotide sequence was amplified and cloned into the standard high-copy expression vector pET15b and then expressed after induction with IPTG in E. coli BL21 (DE3) strain cells containing the inducible phage T7 RNA polymerase gene. The ribT gene expression was confirmed by SDS-PAGE. The protein product of the expression was purified by affinity chromatography. Therefore, the real possibility of RibT protein production in quantities sufficient for further investigation of its structure and functional activity was demonstrated. © 2014 Park-media, Ltd.},\r\nauthor_keywords={Bioinformatics;  Gene cloning;  Homology search;  Inducible expression;  Proteomics;  Theoretical protein structure},\r\ncorrespondence_address1={Timkovskii, A.L.; B.P. Konstantinov Petersburg Nuclear Physics Institute, National Research Center Kurchatov Institute, Orlova RoshchaRussian Federation},\r\npublisher={Russian Federation Agency for Science and Innovation},\r\nissn={20758251},\r\nlanguage={English},\r\nabbrev_source_title={Acta Naturae},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 2013\n \n \n (5)\n \n \n

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\n \n\n \n \n \n \n \n \n The changes in metabolism of the regulatory brain protein NAP-22 at the early stages of postnatal ontogeny in spontaneous hypertensive and WKY rats born to females fed with calcium-deficient diet.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Doklady Biological Sciences, 452(1): 261-265. 2013.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n [Amyloid-like oligomers of presynaptic protein BASP1].\n \n \n \n \n\n\n \n Vitiuk, O.; Gil'iano, N.; and Zakharov, V.\n\n\n \n\n\n\n Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk, 99(8): 984-992. 2013.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"[Amyloid-like$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Vitiuk2013984,\r\nauthor={Vitiuk, O.S. and Gil'iano, N.Ia. and Zakharov, V.V.},\r\ntitle={[Amyloid-like oligomers of presynaptic protein BASP1]},\r\njournal={Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk},\r\nyear={2013},\r\nvolume={99},\r\nnumber={8},\r\npages={984-992},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921960923&partnerID=40&md5=b26982aaa07346c810d558817828e073},\r\nabstract={Brain protein BASP1 forms oligomers that resemble amyloid protein oligomers in some respects, including interaction with conformation-specific antibodies against amyloid oligomers. Aggregation-prone N-terminal myristoylated peptide myr-BASP1 (1-13) forms fibrillar aggregates of amyloid-like structure under physiological conditions in vitro, which is also the evidence of BASP1 similarity to amyloid proteins. Protein cross-linking by glutaraldehyde in situ demonstrated that BASP1 exists on the presynaptic membrane as lipid raft-associated oligomers. In addition, BASP1 is non-toxic to PC12 cells, when applied either as a monomer or oligomer. We conclude that BASP1 oligomer is a non-pathological physiologically relevant functional form of this protein.},\r\nissn={08698139},\r\npubmed_id={25470949},\r\nlanguage={Russian},\r\nabbrev_source_title={Ross Fiziol Zh Im I M Sechenova},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n BASP1 and its N-end fragments (BNEMFs) dynamics in rat brain during development.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Neurochemical Research, 38(6): 1278-1284. 2013.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"BASP1$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Expression of genes involved in retinoic acid biosynthesis in human gastric cancer.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Molecular Biology, 47(2): 280-292. 2013.\n cited By 5\n\n\n\n
\n\n\n\n \n \n $\"Expression$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n [Expression of genes involved in retinoic acid biosynthesis in human gastric cancer].\n \n \n \n \n\n\n \n Kropotova, E.; Zinov'eva, O.; Zyrianova, A.; Choǐnzonov, E.; Afanas'ev, S.; Cherdyntseva, N.; Beresten', S.; Oparina, N.; and Mashkova, T.\n\n\n \n\n\n\n Molekuliarnaia biologiia, 47(2): 317-330. 2013.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"[Expression$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kropotova2013317,\r\nauthor={Kropotova, E.S. and Zinov'eva, O.L. and Zyrianova, A.F. and Choǐnzonov, E.L. and Afanas'ev, S.G. and Cherdyntseva, N.V. and Beresten', S.F. and Oparina, N.I. and Mashkova, T.D.},\r\ntitle={[Expression of genes involved in retinoic acid biosynthesis in human gastric cancer].},\r\njournal={Molekuliarnaia biologiia},\r\nyear={2013},\r\nvolume={47},\r\nnumber={2},\r\npages={317-330},\r\ndoi={10.7868/S0026898413020079},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880990819&doi=10.7868%2fS0026898413020079&partnerID=40&md5=7d16273ffda40e034e6a27800b8dde2a},\r\nabstract={All-trans-retinoic acid (ATRA) is the main biologically active metabolite of retinol (vitamin A) that is required for the regulation of such processes as embryogenesis, tissue differentiation, proliferation, and others. Multiple alcohol, retinol and retinaldehyde dehydrogenases (ADHs, RDHs and RALDHs) as well as aldo-keto reductases (AKRs) catalyze the biosynthesis of retinoic acid in humans. For many normal and neoplastic tissues, the key ATRA-synthesizing enzymes remain unknown. We identified ATRA-generating genes that are expressed in normal and malignant gastric tissues using the transcriptomic database analysis. Quantitative changes in the expression levels of these genes in gastric cancer were determined by semi-quantitative RT-PCR and real-time PCR. Significant decreases in the mRNA levels of genes encoding enzymes that catalyze the reversible oxidation/reduction of retinol and retinaldehyde (ADH4, ADH1B, ADH1C, RDHL, AKR1B10, AKR1B1, and RDH12), as well as the oxidation of retinaldehyde (RALDH1) were revealed in most of the tumor samples. The sharp reduction in the expression levels of genes encoding the key enzymes that convert retinol and retinaldehyde to retinoic acid could lead to a significant decrease in the content of ATRA--the transcriptional regulator of many genes, which in turn can lead to a dysregulation of cell proliferation/differentiation and initiate cancer development.},\r\ncorrespondence_address1={Kropotova, E.S.},\r\nissn={00268984},\r\npubmed_id={23808167},\r\nlanguage={Russian},\r\nabbrev_source_title={Mol. Biol. (Mosk.)},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 2012\n \n \n (5)\n \n \n

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\n \n\n \n \n \n \n \n \n The role of chromatoid bodies and cytoskeleton for differentiation of rat spermatozoids.\n \n \n \n \n\n\n \n Snigirevskaya, E.; Mosevitsky, M.; and Komissarchik, Y.\n\n\n \n\n\n\n Tsitologiya, 54(3): 200-213. 2012.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Snigirevskaya2012200,\r\nauthor={Snigirevskaya, E.S. and Mosevitsky, M.I. and Komissarchik, Ya.Yu.},\r\ntitle={The role of chromatoid bodies and cytoskeleton for differentiation of rat spermatozoids},\r\njournal={Tsitologiya},\r\nyear={2012},\r\nvolume={54},\r\nnumber={3},\r\npages={200-213},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862258238&partnerID=40&md5=358655f5415c8beafdf38679346d9da2},\r\naffiliation={Institute of Cytology RAS, St. Petersburg, Russian Federation; St. Petersburg Institute of Nuclear Physics RAS, Leningrad district, Gatchina, Russian Federation},\r\nabstract={The ultrastructural and immunocytochemical study of rat male germ cells on different developing stages has been made. The investigation of morphological changes of spermatogenic cells has demonstrated the presence of tight connections between chromatoid bodies (CBs) and other cell organelles, particularly with the nucleus and Golgi apparatus; has revealed the association of manchette noncentrosomal microtubules (MT) with spermatid perinuclear ring plasma membrane (PM) in the zone of the adhesion intercellular contact - zonula adhaerens (ZA). The comparison of the results obtained in this work with available literary data has given possibility to analyze expected pathways of noncentrosomal MT nucleation in the late spermatids. This paper puts the supposition that noncentrosomal MTs are nucleated on the sites of perinuclear ring ZA. The immunocytochemical analysis discovered two novel proteins for these cells - BASPl and MARCKS. It has been shown that these proteins present in the CBs in the early spermatids. During the spermatozoid differentiation these proteins are revealed along the outer dense fibers (ODFs) of the sperm tail. BASPl and MARCKS are supposed to involve in the processes of calcium accumulation in the CBs and ODFs. Calcium ions seem to play the significant role in RNA processing and protein synthesis in spermatids. Calcium is also necessary for the mobility of sperms which is mainly determined by ODFs.},\r\nauthor_keywords={BASPl;  Chromatoid body;  Manchette;  MARCKS;  Microtubules;  Outer dense fibers;  Rat spermatogenesis},\r\ncorrespondence_address1={Snigirevskaya, E.S.; Institute of Cytology RAS, St. Petersburg, Russian Federation; email: snigir@mail.cytspb.rssi.ru},\r\nissn={00413771},\r\ncoden={TSITA},\r\npubmed_id={22645984},\r\nlanguage={Russian},\r\nabbrev_source_title={Tsitologiya},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n [The characterization of internal promoters in the Bacillus subtilis riboflavin biosynthesis operon].\n \n \n \n \n\n\n \n Skliarova, S.; Kreneva, R.; Perumov, D.; and Mironov, A.\n\n\n \n\n\n\n Genetika, 48(10): 1133-1141. 2012.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"[The$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Skliarova20121133,\r\nauthor={Skliarova, S.A. and Kreneva, R.A. and Perumov, D.A. and Mironov, A.S.},\r\ntitle={[The characterization of internal promoters in the Bacillus subtilis riboflavin biosynthesis operon].},\r\njournal={Genetika},\r\nyear={2012},\r\nvolume={48},\r\nnumber={10},\r\npages={1133-1141},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84873728613&partnerID=40&md5=fb706ef7671ae89ae1614503aa73d027},\r\nabstract={The transcription start sites of two internal promoters, the P2 and P3 promoters, in the Bacillus subtilis riboflavin biosynthesis operon were identified by primer extension. Putative -35 and -10 sequences that are recognized by the vegetative delta(70) subunit of RNA polymerase have been found upstream of the P2 and P3 transcription start sites. The relative strengths of the P1, P2, and P3 promoters were determined by cloning these promoters into the pDG268 expression vector. It was shown that the transcriptional activity of the P3 promoter is approximately fivefold higher as compared with P1, the major promoter, whereas P2 promoter activity is lower by almost two orders of magnitude. Real-time PCR demonstrated that unlike the P1 promoter, P2- and P3-driven expression is not regulated by flavins.},\r\ncorrespondence_address1={Skliarova, S.A.},\r\nissn={00166758},\r\npubmed_id={23270261},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n The characterization of internal promoters in the Bacillus subtilis riboflavin biosynthesis operon.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Russian Journal of Genetics, 48(10): 967-974. 2012.\n cited By 4\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n The role of chromatoid bodies and cytoskeleton in differentiation of rat spermatozoids.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Cell and Tissue Biology, 6(3): 254-267. 2012.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Immunoelectron microscopic study of BASP1 and MARCKS location in the early and late rat spermatids.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Acta Histochemica, 114(3): 237-243. 2012.\n cited By 12\n\n\n\n
\n\n\n\n \n \n $\"Immunoelectron$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 2011\n \n \n (6)\n \n \n

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\n \n\n \n \n \n \n \n \n [Mutational analysis of the ribC gene of Bacillus subtilis].\n \n \n \n \n\n\n \n Karelov, D.; Kreneva, R.; Érraǐs Lopes, L.; Perumov, D.; and Mironov, A.\n\n\n \n\n\n\n Genetika, 47(6): 856-861. 2011.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"[Mutational$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Karelov2011856,\r\nauthor={Karelov, D.V. and Kreneva, R.A. and Érraǐs Lopes, L. and Perumov, D.A. and Mironov, A.S.},\r\ntitle={[Mutational analysis of the ribC gene of Bacillus subtilis].},\r\njournal={Genetika},\r\nyear={2011},\r\nvolume={47},\r\nnumber={6},\r\npages={856-861},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052872912&partnerID=40&md5=3d656e04cd876734248350dc111e2b71},\r\nabstract={The nucleotide sequence of the ribC gene encoding the synthesis ofbifunctional flavokinase/flavine adenine nucleotide (FAD) synthetase in Bacillus subtilis have been determined in a family of riboflavin-constitutive mutants. Two mutations have been found in the proximal region of the gene, which controls the transferase (FAD synthase) activity. Three point mutations and one double mutation have been found (in addition to the two mutations that were detected earlier) in the distal region of the gene, which controls the flavokinase (flavin mononucleotide (FMN) synthase) activity. On the basis of all data known to date, it has been concluded that the identified mutations affect riboflavin and ATP binding sites. No mutations have been found in the PTAN conserved sequence, which forms the magnesium and ATP common binding site and is identical for organisms of all organizational levels, from bacteria too humans.},\r\ncorrespondence_address1={Karelov, D.V.},\r\nissn={00166758},\r\npubmed_id={21866869},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Mutational analysis of the ribC gene of Bacillus subtilis.\n \n \n \n \n\n\n \n Karelov, D.; Kreneva, R.; Lopes, L.; Perumov, D.; and Mironov, A.\n\n\n \n\n\n\n Russian Journal of Genetics, 47(6): 757-761. 2011.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Mutational$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Karelov2011757,\r\nauthor={Karelov, D.V. and Kreneva, R.A. and Lopes, L.E. and Perumov, D.A. and Mironov, A.S.},\r\ntitle={Mutational analysis of the ribC gene of Bacillus subtilis},\r\njournal={Russian Journal of Genetics},\r\nyear={2011},\r\nvolume={47},\r\nnumber={6},\r\npages={757-761},\r\ndoi={10.1134/S102279541106010X},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-79958851598&doi=10.1134%2fS102279541106010X&partnerID=40&md5=804e8dfeb473490e10c353032d7f4436},\r\naffiliation={Laboratory of Biophysics, Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, Leningrad oblast, 188300, Russian Federation; St. Petersburg State Polytechnical University, St. Petersburg, 195251, Russian Federation; State Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow, 117545, Russian Federation},\r\nabstract={The nucleotide sequence of the ribC gene encoding the synthesis of bifunctional flavokinase/flavine adenine nucleotide (FAD) synthetase in Bacillus subtilis have been determined in a family of riboflavinconstitutive mutants. Two mutations have been found in the proximal region of the gene, which controls the transferase (FAD synthase) activity. Three point mutations and one double mutation have been found (in addition to the two mutations that were detected earlier) in the distal region of the gene, which controls the flavokinase (flavin mononucleotide (FMN) synthase) activity. On the basis of all data known to date, it has been concluded that the identified mutations affect riboflavin and ATP binding sites. No mutations have been found in the PTAN conserved sequence, which forms the magnesium and ATP common binding site and is identical for organisms of all organizational levels, from bacteria too humans. © 2011 Pleiades Publishing, Ltd.},\r\ncorrespondence_address1={Karelov, D. V.; Laboratory of Biophysics, Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, Leningrad oblast, 188300, Russian Federation; email: karelov_denis@mail.ru},\r\nissn={10227954},\r\nlanguage={English},\r\nabbrev_source_title={Russ. J. Gen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n On the activation of calcium-dependent proteolysis in brain neurons of Spontaneously Hypertensive Rats (SHR strain).\n \n \n \n \n\n\n \n Zakharov, V.; Abramova, Y.; and Mosevitsky, M.\n\n\n \n\n\n\n Bulletin of Experimental Biology and Medicine, 150(5): 587-589. 2011.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"On$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Zakharov2011587,\r\nauthor={Zakharov, V.V. and Abramova, Yu.K. and Mosevitsky, M.I.},\r\ntitle={On the activation of calcium-dependent proteolysis in brain neurons of Spontaneously Hypertensive Rats (SHR strain)},\r\njournal={Bulletin of Experimental Biology and Medicine},\r\nyear={2011},\r\nvolume={150},\r\nnumber={5},\r\npages={587-589},\r\ndoi={10.1007/s10517-011-1197-z},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-79959280693&doi=10.1007%2fs10517-011-1197-z&partnerID=40&md5=a0392c1981e56ba0a4562bd19a933f2e},\r\naffiliation={Department of Molecular and Radiational Biophysics, B. P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russian Federation},\r\nabstract={Females of spontaneously hypertensive (SHR strain) and normotensive rats (WKY strain and Wistar) received drinking water with normal (80 mg/liter) or reduced concentration of Ca2+ (8 mg/liter). Activity of calcium-dependent calpain protease in neurons did not differ in 18-dayold rat pups born and suckled by these animals. Our results are consistent with published data on normal metabolism of SHR rats up to the age of 30 days. © 2011 Springer Science+Business Media, Inc.},\r\nauthor_keywords={Calcium paradox;  Calcium-dependent calpain protease;  Hypertension;  Spontaneously hypertensive rats},\r\ncorrespondence_address1={Zakharov, V. V.; Department of Molecular and Radiational Biophysics, B. P. Konstantinov Petersburg Nuclear Physics Institute, Gatchina, Russian Federation; email: vlad.v.zakharov@mail.ru},\r\nissn={00074888},\r\ncoden={BEXBA},\r\npubmed_id={22235391},\r\nlanguage={English},\r\nabbrev_source_title={Bull. Exp. Biol. Med.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Ion channel activity of brain abundant protein BASP1 in planar lipid bilayers.\n \n \n \n \n\n\n \n Ostroumova, O.; Schagina, L.; Mosevitsky, M.; and Zakharov, V.\n\n\n \n\n\n\n FEBS Journal, 278(3): 461-469. 2011.\n cited By 24\n\n\n\n
\n\n\n\n \n \n $\"Ion$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Ostroumova2011461,\r\nauthor={Ostroumova, O.S. and Schagina, L.V. and Mosevitsky, M.I. and Zakharov, V.V.},\r\ntitle={Ion channel activity of brain abundant protein BASP1 in planar lipid bilayers},\r\njournal={FEBS Journal},\r\nyear={2011},\r\nvolume={278},\r\nnumber={3},\r\npages={461-469},\r\ndoi={10.1111/j.1742-4658.2010.07967.x},\r\nnote={cited By 24},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-78751660210&doi=10.1111%2fj.1742-4658.2010.07967.x&partnerID=40&md5=8d1f1afd85cf5a3030e3348ccc46d247},\r\naffiliation={Laboratory of Ionic Channels of Cell Membranes, Institute of Cytology of RAS, St Petersburg, Russian Federation; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad District, 188300 Gatchina, Russian Federation},\r\nabstract={BASP1 (also known as CAP-23 and NAP-22) is a brain abundant myristoylated protein localized at the inner surface of the presynaptic plasma membrane. Emerging evidence suggests that BASP1 is critically involved in various cellular processes, in particular, in the accumulation of phosphatidylinositol-4,5- diphosphate (PIP2) in lipid raft microdomains. We have recently shown that BASP1 forms heterogeneously-sized oligomers and higher aggregates with an outward similarity to oligomers and protofibrils of amyloid proteins. However, BASP1 is not known to be related to any amyloid disease. In the present study, we show that BASP1 induces single channel currents across negatively-charged planar lipid bilayers (containing phosphatidylserine or PIP2) bathed in 0.1-0.2 m KCl (pH 7.5). By their characteristics, BASP1 channels are similar to amyloid protein channels. BASP1 channels exhibit multiple conductance levels, in the range 10-3000 pS, with the most frequently observed conductance state of approximately 50 pS. The channels demonstrate a linear current-voltage relationship and voltage-independent kinetics of opening and closing. Their K+ to Cl- permeability ratio is approximately 14, indicating that BASP1 channels are cation-selective. The ion channel activity of BASP1 is in accordance with the pore-like structure of BASP1 oligomers observed by electron microscopy on a lipid monolayer. Neuronal protein GAP-43, which is functionally related to BASP1 and also forms oligomers, elicited no ion channel currents under the conditions used in the present study. Elucidation of the physiological or pathological roles of ion channel activity of membrane-bound BASP1 oligomers will help to define the precise mechanism of amyloid protein toxicity. © 2010 The Authors Journal compilation © 2010 FEBS.},\r\nauthor_keywords={amyloid proteins;  BASP1;  ion channels;  lipid bilayer;  protein oligomers},\r\ncorrespondence_address1={Zakharov, V. V.; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad District, 188300 Gatchina, Russian Federation; email: vlad.v.zakharov@mail.ru},\r\nissn={1742464X},\r\npubmed_id={21156029},\r\nlanguage={English},\r\nabbrev_source_title={FEBS J.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Subcellular and regional location of \"brain\" proteins BASP1 and MARCKS in kidney and testis.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Acta Histochemica, 113(1): 13-18. 2011.\n cited By 14\n\n\n\n
\n\n\n\n \n \n $\"Subcellular$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Mass spectrometry and biochemical analysis of RNA polymerase II: Targeting by protein phosphatase-1.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Molecular and Cellular Biochemistry, 347(1-2): 79-87. 2011.\n cited By 14\n\n\n\n
\n\n\n\n \n \n $\"Mass$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 2010\n \n \n (5)\n \n \n

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\n \n\n \n \n \n \n \n \n Role of the growth-associated protein GAP-43 in NCAM-mediated neurite outgrowth.\n \n \n \n \n\n\n \n Korshunova, I.; and Mosevitsky, M.\n\n\n \n\n\n\n Advances in Experimental Medicine and Biology, 663: 169-182. 2010.\n cited By 27\n\n\n\n
\n\n\n\n \n \n $\"Role$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Korshunova2010169,\r\nauthor={Korshunova, I. and Mosevitsky, M.},\r\ntitle={Role of the growth-associated protein GAP-43 in NCAM-mediated neurite outgrowth},\r\njournal={Advances in Experimental Medicine and Biology},\r\nyear={2010},\r\nvolume={663},\r\npages={169-182},\r\ndoi={10.1007/978-1-4419-1170-4_11},\r\nnote={cited By 27},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-77949883524&doi=10.1007%2f978-1-4419-1170-4_11&partnerID=40&md5=1a6b373eece4328da1a63c8f2d53769c},\r\naffiliation={Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad District, Gatchina, Russian Federation},\r\ncorrespondence_address1={Korshunova, I.; Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark; email: irina@sund.ku.dk},\r\neditor={Berezin V.},\r\nissn={00652598},\r\nisbn={9781441911698},\r\ncoden={AEMBA},\r\npubmed_id={20017022},\r\nlanguage={English},\r\nabbrev_source_title={Adv. Exp. Med. Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Oligomeric structure of brain abundant proteins GAP-43 and BASP1.\n \n \n \n \n\n\n \n Zakharov, V.; and Mosevitsky, M.\n\n\n \n\n\n\n Journal of Structural Biology, 170(3): 470-483. 2010.\n cited By 22\n\n\n\n
\n\n\n\n \n \n $\"Oligomeric$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Zakharov2010470,\r\nauthor={Zakharov, V.V. and Mosevitsky, M.I.},\r\ntitle={Oligomeric structure of brain abundant proteins GAP-43 and BASP1},\r\njournal={Journal of Structural Biology},\r\nyear={2010},\r\nvolume={170},\r\nnumber={3},\r\npages={470-483},\r\ndoi={10.1016/j.jsb.2010.01.010},\r\nnote={cited By 22},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-77952583522&doi=10.1016%2fj.jsb.2010.01.010&partnerID=40&md5=270f1ead550b8040f94ace617d3db286},\r\naffiliation={Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute of Russian Academy of Sciences, 188300 Gatchina, Leningrad District, Russian Federation},\r\nabstract={Brain abundant proteins GAP-43 and BASP1 participate in the regulation of actin cytoskeleton dynamics in neuronal axon terminals. The proposed mechanism suggests that the proteins sequester phosphatidylinositol-4,5-diphosphate (PIP2) in the inner leaflet of the plasma membrane. We found that model anionic phospholipid membranes in the form of liposomes induce rapid oligomerization of GAP-43 and BASP1 proteins. Multiply charged phosphoinositides produced the most potent effect. Anionic detergent sodium dodecyl sulfate (SDS) at submicellar concentration stimulated formation of similar oligomers in solution. BASP1, but not GAP-43, also formed oligomers at sufficiently high concentration in the absence of lipids and SDS. Electron microscopy study demonstrated that the oligomers have disk-shaped or annular structure of 10-30nm in diameter. BASP1 also formed higher aggregates of linear rod-like structure, with average length of about 100nm. In outward appearance, the oligomers and linear aggregates are reminiscent of oligomers and protofibrils of amyloid proteins. Both the synthetic N-terminal peptide GAP-43(1-40) and the brain-derived fragment GAP-43-3 preserved the ability to oligomerize under the action of acidic phospholipids and SDS. On the contrary, BASP1 fragment truncated by the short N-terminal myristoylated peptide was unable to form oligomers. GAP-43 and BASP1 oligomerization can be regulated by calmodulin, which disrupts the oligomers and displaces the proteins from the membrane. We suggest that in vivo, the role of membrane-bound GAP-43 and BASP1 oligomers consists in accumulation of PIP2 in functional clusters, which become accessible for other PIP2-binding proteins after dissociation of the oligomers. © 2010 Elsevier Inc.},\r\nauthor_keywords={Amyloid proteins;  BASP1;  GAP-43;  Phosphatidylinositol-4,5-diphosphate;  Protein oligomers;  SDS},\r\nfunding_details={Российский Фонд Фундаментальных Исследований (РФФИ)05-04-49142, 08-04-00432},\r\nfunding_details={Council on grants of the President of the Russian FederationMK-5314.2008.4},\r\n}

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\n \n\n \n \n \n \n \n \n Downregulation of AKR1B10 expression in colorectal cancer.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Molecular Biology, 44(2): 216-222. 2010.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"Downregulation$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Downregulation of AKR1B10 gene expression in colorectal cancer.\n \n \n \n \n\n\n \n Kropotova, E.; Tychko, R.; Zinov'eva, O.; Zyrianova, A.; Khankin, S.; Cherkes, V.; Aliev, V.; Beresten', S.; Oparina, N.; and Mashkova, T.\n\n\n \n\n\n\n Molekuliarnaia biologiia, 44(2): 243-250. 2010.\n cited By 11\n\n\n\n
\n\n\n\n \n \n $\"Downregulation$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kropotova2010243,\r\nauthor={Kropotova, E.S. and Tychko, R.A. and Zinov'eva, O.L. and Zyrianova, A.F. and Khankin, S.L. and Cherkes, V.L. and Aliev, V.A. and Beresten', S.F. and Oparina, N.I. and Mashkova, T.D.},\r\ntitle={Downregulation of AKR1B10 gene expression in colorectal cancer},\r\njournal={Molekuliarnaia biologiia},\r\nyear={2010},\r\nvolume={44},\r\nnumber={2},\r\npages={243-250},\r\nnote={cited By 11},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955078547&partnerID=40&md5=c259fd8dbd06c98937661f46fedce453},\r\nabstract={Colorectal cancer is one of the most common cancers in the world. In our work changes of AKR1B1 and AKR1B10 gene expression levels in colorectal tumors were studied. Their potential diagnostic value was previously shown for several other cancer types. These genes encode aldoso reductases, which belong to the aldo-keto reductases superfamily consisting of enzymes capable to reduce numerous aromatic and aliphatic aldehydes and ketones. They are also involved into retinoid metabolism and cancerogenesis. We have carried out comparative analysis of mRNA levels of AKR1B1 and AKR1B10 genes in paired samples of normal and colorectal tumor tissues using RT-PCR and quantitative PCR. We have shown for the first time the decrease of activity of these genes in colorectal carcinomas. Significant reduction of AKR1B10 mRNA level was detected in the most of tumor samples (88%, 65/74) even at the early stages of malignancy, and in more than 60% of cases this downregulation was much higher than 10 folds. The decrease of AKR1B1 mRNA level was shown in 10% of tumors only. Therefore, we have detected quite different mRNA expression patterns in colorectal cancer for these two structurally similar genes. These data could indicate different functional roles of these two genes in colorectum. The significant decrease of AKR1B10 mRNA in most samples of colorectal cancer could be considered as potential diagnostic marker of this type of cancer.},\r\ncorrespondence_address1={Kropotova, E.S.},\r\nissn={00268984},\r\npubmed_id={20586184},\r\nlanguage={Russian},\r\nabbrev_source_title={Mol. Biol. (Mosk.)},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n L-NAME-induced heavy proteinuria in healthy rats.\n \n \n \n \n\n\n \n Kutina, A.; Zakharov, V.; Shahmatova, E.; and Natochin, Y.\n\n\n \n\n\n\n Doklady Biological Sciences, 430(1): 26-28. 2010.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"L-NAME-induced$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kutina201026,\r\nauthor={Kutina, A.V. and Zakharov, V.V. and Shahmatova, E.I. and Natochin, Y.V.},\r\ntitle={L-NAME-induced heavy proteinuria in healthy rats},\r\njournal={Doklady Biological Sciences},\r\nyear={2010},\r\nvolume={430},\r\nnumber={1},\r\npages={26-28},\r\ndoi={10.1134/S0012496610010096},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-77349101545&doi=10.1134%2fS0012496610010096&partnerID=40&md5=d7601405944b936b4e60638d4b2462e8},\r\naffiliation={Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, pr. Morisa Toreza 44, St. Petersburg 194223, Russian Federation; Konstantinov St. Petersburg Institute of Nuclear Physics, Russian Academy of Sciences, Orlova Roshcha, Gatchina, Leningrad oblast 188300, Russian Federation},\r\nfunding_details={08 04 00610},\r\n}

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\n \n 2009\n \n \n (4)\n \n \n

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\n \n\n \n \n \n \n \n \n Multifunctional regulatory mutation in Bacillus subtilis flavinogenesis system.\n \n \n \n \n\n\n \n Kreneva, R.; Karelov, D.; Korol'kova, N.; Mironov, A.; and Perumov, D.\n\n\n \n\n\n\n Genetika, 45(10): 1420-1424. 2009.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Multifunctional$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva20091420,\r\nauthor={Kreneva, R.A. and Karelov, D.V. and Korol'kova, N.V. and Mironov, A.S. and Perumov, D.A.},\r\ntitle={Multifunctional regulatory mutation in Bacillus subtilis flavinogenesis system},\r\njournal={Genetika},\r\nyear={2009},\r\nvolume={45},\r\nnumber={10},\r\npages={1420-1424},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-73349140528&partnerID=40&md5=4f353fcfe7668542224696b82cff7ad3},\r\nabstract={Among Bacillus subtilis riboflavin-resistant mutants we identified one, which differed from other regulatory mutants by overproduction of riboflavin and simultaneous upregulation of the rib C gene encoding flavokinase/FAD-synthase. Genetic and biochemical analysis showed that the ribU1 mutation determines a trans-acting factor that simultaneously regulates activity of riboflavin and truB-ribC-rpsO operons. Regulatory activity of the ribU1 mutation comprises about 10% of Rfn element activity on interaction with flavins. The ribUl mutation can be presumably ascribed to a gene of the transcriptional regulators family.},\r\ncorrespondence_address1={Kreneva, R.A.},\r\nissn={00166758},\r\npubmed_id={19947554},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Multifunctional regulatory mutation in bacillus subtilis flavinogenesis system.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Russian Journal of Genetics, 45(10): 1256-1259. 2009.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Multifunctional$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Roles of the outer membrane protein asmA of Salmonella enterica in the control of marRAB expression and invasion of epithelial cells.\n \n \n \n \n\n\n \n Prieto, A.; Hernández, S.; Cota, I.; Pucciarelli, M.; Orlov, Y.; Ramos-Morales, F.; García-Del Portillo, F.; and Casadesús, J.\n\n\n \n\n\n\n Journal of Bacteriology, 191(11): 3615-3622. 2009.\n cited By 22\n\n\n\n
\n\n\n\n \n \n $\"Roles$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Prieto20093615,\r\nauthor={Prieto, A.I. and Hernández, S.B. and Cota, I. and Pucciarelli, M.G. and Orlov, Y. and Ramos-Morales, F. and García-Del Portillo, F. and Casadesús, J.},\r\ntitle={Roles of the outer membrane protein asmA of Salmonella enterica in the control of marRAB expression and invasion of epithelial cells},\r\njournal={Journal of Bacteriology},\r\nyear={2009},\r\nvolume={191},\r\nnumber={11},\r\npages={3615-3622},\r\ndoi={10.1128/JB.01592-08},\r\nnote={cited By 22},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-66149121872&doi=10.1128%2fJB.01592-08&partnerID=40&md5=dd604fb49dbd1e50b8b91a02604e7e06},\r\naffiliation={Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, E-41080 Seville, Spain; Departamento de Biología Molecular, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain; Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, C. S. I. C, Darwin 3, Cantoblanco, 28049 Madrid, Spain; Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, United Kingdom; Biophysics Department, St. Petersburg Polytechnical University, Polytekhnicheskaya St., 195251 Saint Petersburg, Russian Federation},\r\nabstract={A genetic screen for suppressors of bile sensitivity in DNA adenine methylase (dam) mutants of Salmonella enterica serovar Typhimurium yielded insertions in an uncharacterized locus homologous to the Escherichia coli asmA gene. Disruption of asmA suppressed bile sensitivity also in phoP and wec mutants of S. enterica and increased the MIC of sodium deoxycholate for the parental strain ATCC 14028. Increased levels of marA mRNA were found in asmA, asmA dam, asmA phoP, and asmA wec strains of S. enterica, suggesting that lack of AsmA activates expression of the marRAB operon. Hence, asmA mutations may enhance bile resistance by inducing gene expression changes in the marRAB-controlled Mar regulon. In silico analysis of AsmA structure predicted the existence of one transmembrane domain. Biochemical analysis of subcellular fractions revealed that the asmA gene of S. enterica encodes a protein of ∼70 kDa located in the outer membrane. Because AsmA is unrelated to known transport and/or efflux systems, we propose that activation of marRAB in asmA mutants may be a consequence of envelope reorganization. Competitive infection of BALB/c mice with asmA+ and asmA isogenic strains indicated that lack of AsmA attenuates Salmonella virulence by the oral route but not by the intraperitoneal route. Furthermore, asmA mutants showed a reduced ability to invade epithelial cells in vitro. Copyright © 2009, American Society for Microbiology. All Rights Reserved.},\r\ncorrespondence_address1={Casadesús, J.; Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, E-41080 Seville, Spain; email: casadesus@us.es},\r\nissn={00219193},\r\ncoden={JOBAA},\r\npubmed_id={19346309},\r\nlanguage={English},\r\nabbrev_source_title={J. Bacteriol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Coupling of Na+/α-ketoglutarate symport and PAH/α-ketoglutarate antiport in epithelial cells. Estimation of probability of the anion exchanger spontaneous re-orientation.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Journal of Evolutionary Biochemistry and Physiology, 45(1): 86-90. 2009.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Coupling$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 2008\n \n \n (4)\n \n \n

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\n \n\n \n \n \n \n \n \n Excretion of proteins by rat kidney during various types of diuresis.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Bulletin of Experimental Biology and Medicine, 146(6): 671-674. 2008.\n cited By 8\n\n\n\n
\n\n\n\n \n \n $\"Excretion$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds.\n \n \n \n \n\n\n \n Bogdanov, A.; Ivanov, Y.; Kasyanenko, N.; Potekhin, S.; Surzhik, M.; Timkovskii, A.; Feofanov, S.; Khusainova, R.; and Yakoblev, K.\n\n\n \n\n\n\n Biophysics, 53(5): 341-343. 2008.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Destabilization$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bogdanov2008341,\r\nauthor={Bogdanov, A.A. and Ivanov, Yu.V. and Kasyanenko, N.A. and Potekhin, S.A. and Surzhik, M.A. and Timkovskii, A.L. and Feofanov, S.A. and Khusainova, R.S. and Yakoblev, K.I.},\r\ntitle={Destabilization and stabilization of poly(A) • poly(U) structure by platinum(II) compounds},\r\njournal={Biophysics},\r\nyear={2008},\r\nvolume={53},\r\nnumber={5},\r\npages={341-343},\r\ndoi={10.1134/S0006350908050035},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-59849113492&doi=10.1134%2fS0006350908050035&partnerID=40&md5=c78d7a84eb36d3a25a361100d8b9e942},\r\naffiliation={St. Petersburg State University, St. Petersburg, Russian Federation; Konstantinov Petersburg Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, Leningrad oblast, Russian Federation; Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russian Federation; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russian Federation; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russian Federation; St. Petersburg State Chemicopharmaceutical Academy, St. Petersburg, Russian Federation},\r\nabstract={A methodology for analyzing the intramolecular structural order of the polynucleotide duplex poly(A) • poly(U) has been developed on the basis of molecular biophysics. The combination of circular dichroism spectroscopy and differential scanning calorimetry was shown to be an optimal approach. It ensures the screening of a wide set of substances and interaction conditions and the choice of compound(s) capable of stabilizing the structure and increasing the biological activity of this duplex. The study is aimed at obtaining a new and highly active antiviral drug. © 2008 Pleiades Publishing, Ltd.},\r\nauthor_keywords={Polynucleotide interferon inducers;  Structure-activity relationships},\r\ncorrespondence_address1={Bogdanov, A. A.; St. Petersburg State University, St. Petersburg, Russian Federation},\r\nissn={00063509},\r\nlanguage={English},\r\nabbrev_source_title={Biophysics},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Relationship between the secondary structure and the regulatory activity of the leader region of the riboflavin biosynthesis operon in Bacillus subtilis.\n \n \n \n \n\n\n \n Mironov, A.; Karelov, D.; Solov'eva, I.; Eremina, S.; Errais-Lopes, L.; Kreneva, R.; and Perumov, D.\n\n\n \n\n\n\n Genetika, 44(4): 467-473. 2008.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Relationship$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mironov2008467,\r\nauthor={Mironov, A.S. and Karelov, D.V. and Solov'eva, I.M. and Eremina, S.I. and Errais-Lopes, L. and Kreneva, R.A. and Perumov, D.A.},\r\ntitle={Relationship between the secondary structure and the regulatory activity of the leader region of the riboflavin biosynthesis operon in Bacillus subtilis},\r\njournal={Genetika},\r\nyear={2008},\r\nvolume={44},\r\nnumber={4},\r\npages={467-473},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-51549103338&partnerID=40&md5=ac4d7a6f53c966f44ba8bca3ca505865},\r\nabstract={Insertion and deletion mutagenesis of the leader region of the Bacillus subtilis rib operon encoding FMN-specific sensor RNA was conducted. Insertions of different structure and length in the conservative motif of the leader sequence (Rfn-element) were shown to cause partially constitutive expression of the operon resulted in an increased accumulation of riboflavin. At the same time, introducing into the genome of insertion mutants an additional ribC mutation blocking FMN synthesis leads to an increase in riboflavin production. Deletion of the main Rho-dependent transcription terminator gives rise to the same effect. These results indicate that some additional FMN-dependent regulation is involved in rib-operon control, which is, however, still connected with the primary and secondary structure of the leader region.},\r\ncorrespondence_address1={Mironov, A.S.},\r\nissn={00166758},\r\npubmed_id={18666549},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Mathematical model of cooperative work of ion pump, symport and antiport in epithelial cells.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Journal of Evolutionary Biochemistry and Physiology, 44(1): 36-43. 2008.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Mathematical$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 2007\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3.\n \n \n \n \n\n\n \n Zakharov, V.; and Mosevitsky, M.\n\n\n \n\n\n\n Journal of Neurochemistry, 101(6): 1539-1551. 2007.\n cited By 26\n\n\n\n
\n\n\n\n \n \n $\"M-calpain-mediated$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Zakharov20071539,\r\nauthor={Zakharov, V.V. and Mosevitsky, M.I.},\r\ntitle={M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3},\r\njournal={Journal of Neurochemistry},\r\nyear={2007},\r\nvolume={101},\r\nnumber={6},\r\npages={1539-1551},\r\ndoi={10.1111/j.1471-4159.2007.04452.x},\r\nnote={cited By 26},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-34249777520&doi=10.1111%2fj.1471-4159.2007.04452.x&partnerID=40&md5=bc1f3936dae791ae6857f19dcaa39ae4},\r\naffiliation={Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad District, Gatchina, Russian Federation; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad District, 188300 Gatchina, Russian Federation},\r\nabstract={Neuronal protein GAP-43 performs multiple functions in axon guidance, synaptic plasticity and regulation of neuronal death and survival. However, the molecular mechanisms of its action in these processes are poorly understood. We have shown that in axon terminals GAP-43 is a substrate for calcium-activated cysteine protease m-calpain, which participates in repulsion of axonal growth cones and induction of neuronal death. In pre-synaptic terminals in vivo, in synaptosomes, and in vitro, m-calpain cleaved GAP-43 in a small region near Ser41, on either side of this residue. In contrast, μ-calpain cleaved GAP-43 in vitro at several other sites, besides Ser41. Phosphorylation of Ser41 by protein kinase C or GAP-43 binding to calmodulin strongly suppressed GAP-43 proteolysis by m-calpain. A GAP-43 fragment, lacking about forty N-terminal residues (named GAP-43-3), was produced by m-calpain-mediated cleavage of GAP-43 and inhibited m-calpain, but not μ-calpain. This fragment prevented complete cleavage of intact GAP-43 by m-calpain as a negative feedback. GAP-43-3 also blocked m-calpain activity against casein, a model calpain substrate. This implies that GAP-43-3, which is present in axon terminals in high amount, can play important role in regulation of m-calpain activity in neurons. We suggest that GAP-43-3 and another (N-terminal) GAP-43 fragment produced by m-calpain participate in modulation of neuronal response to repulsive and apoptotic signals. © 2007 The Authors.},\r\nauthor_keywords={Calmodulin;  Calpain;  Calpastatin;  GAP-43;  Protein kinase C;  Synaptosomes},\r\ncorrespondence_address1={Zakharov, V.V.; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad District, 188300 Gatchina, Russian Federation; email: v.zakharov@vz5518.spb.edu},\r\nissn={00223042},\r\ncoden={JONRA},\r\npubmed_id={17326767},\r\nlanguage={English},\r\nabbrev_source_title={J. Neurochem.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n GAP-43 regulates NCAM-180-mediated neurite outgrowth.\n \n \n \n \n\n\n \n Korshunova, I.; Novitskaya, V.; Kiryushko, D.; Pedersen, N.; Kolkova, K.; Kropotova, E.; Mosevitsky, M.; Rayko, M.; Morrow, J.; Ginzburg, I.; Berezin, V.; and Bock, E.\n\n\n \n\n\n\n Journal of Neurochemistry, 100(6): 1599-1612. 2007.\n cited By 57\n\n\n\n
\n\n\n\n \n \n $\"GAP-43$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Korshunova20071599,\r\nauthor={Korshunova, I. and Novitskaya, V. and Kiryushko, D. and Pedersen, N. and Kolkova, K. and Kropotova, E. and Mosevitsky, M. and Rayko, M. and Morrow, J.S. and Ginzburg, I. and Berezin, V. and Bock, E.},\r\ntitle={GAP-43 regulates NCAM-180-mediated neurite outgrowth},\r\njournal={Journal of Neurochemistry},\r\nyear={2007},\r\nvolume={100},\r\nnumber={6},\r\npages={1599-1612},\r\ndoi={10.1111/j.1471-4159.2006.04316.x},\r\nnote={cited By 57},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847711498&doi=10.1111%2fj.1471-4159.2006.04316.x&partnerID=40&md5=a0ffb205e843ed02aa0cd905edfc480b},\r\naffiliation={Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen, DK-2200 Copenhagen, Denmark; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Leningrad District, 188300 Gatchina, Russian Federation; Department of Pathology, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06510, United States; Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel},\r\nabstract={The neural cell adhesion molecule (NCAM), and the growth-associated protein (GAP-43), play pivotal roles in neuronal development and plasticity and possess interdependent functions. However, the mechanisms underlying the functional association of GAP-43 and NCAM have not been elucidated. In this study we show that (over)expression of GAP-43 in PC12E2 cells and hippocampal neurons strongly potentiates neurite extension, both in the absence and in the presence of homophilic NCAM binding. This potentiation is crucially dependent on the membrane association of GAP-43. We demonstrate that phosphorylation of GAP-43 by protein kinase C (PKC) as well as by casein kinase II (CKII) is important for the NCAM-induced neurite outgrowth. Moreover, our results indicate that in the presence of GAP-43, NCAM-induced neurite outgrowth requires functional association of NCAM-180/spectrin/GAP-43, whereas in the absence of GAP-43, the NCAM-140/non-receptor tyrosine kinase (Fyn)-associated signaling pathway is pivotal. Thus, expression of GAP-43 presumably acts as a functional switch for NCAM-180-induced signaling. This suggests that under physiological conditions, spatial and/or temporal changes of the localization of GAP-43 and NCAM on the cell membrane may determine the predominant signaling mechanism triggered by homophilic NCAM binding: NCAM-180/spectrin-mediated modulation of the actin cytoskeleton, NCAM-140-mediated activation of Fyn, or both. © 2007 The Authors.},\r\nauthor_keywords={Growth-associated protein;  Hippocampal;  Neural cell adhesion molecule;  PC12;  Spectrin},\r\ncorrespondence_address1={Korshunova, I.; Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen, DK-2200 Copenhagen, Denmark; email: irina@plab.ku.dk},\r\nissn={00223042},\r\ncoden={JONRA},\r\npubmed_id={17212696},\r\nlanguage={English},\r\nabbrev_source_title={J. Neurochem.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 2006\n \n \n (3)\n \n \n

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\n \n\n \n \n \n \n \n \n Heat shock proteins of freshwater protists and their involvement in adaptation to changes in the environmental salinity.\n \n \n \n \n\n\n \n Plekhanov, A.; Smurov, A.; Podlipaeva, Y.; Ivanova, L.; and Goodkov, A.\n\n\n \n\n\n\n Tsitologiya, 48(6): 530-534. 2006.\n cited By 7\n\n\n\n
\n\n\n\n \n \n $\"Heat$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Plekhanov2006530,\r\nauthor={Plekhanov, A.Yu. and Smurov, A.O. and Podlipaeva, Yu.I. and Ivanova, L.O. and Goodkov, A.V.},\r\ntitle={Heat shock proteins of freshwater protists and their involvement in adaptation to changes in the environmental salinity},\r\njournal={Tsitologiya},\r\nyear={2006},\r\nvolume={48},\r\nnumber={6},\r\npages={530-534},\r\nnote={cited By 7},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750099708&partnerID=40&md5=ced530f788b0149c8836cb222084bbff},\r\naffiliation={St. Petersburg Nuclear Physics Institute, RAS, St. Petersburg, Russian Federation; Zoological Institute, RAS, St. Petersburg, Russian Federation; Biological Research Institute, St. Petersburg State University, St. Petersburg, Russian Federation; Institute of Cytology, RAS, St. Petersburg, Russian Federation},\r\nabstract={Changes in the level of heat shock proteins (HSP) in cells of freshwater protists, amoebae Amoeba proteus and ciliates Paramecium jenningsi, in response to changes in the environmental salinity were investigated. Changes in salinity levels were considered as a stress factor. The immunoblotting method revealed a polypeptide antigen cross-reacting with antibodies against bovine HSP70 in total protein extracts of both intact cells and cells subjected to salinity stress. The same polypeptide antigen was revealed in A. proteus cells subjected to heat shock. Therefore, it may be supposed that the polypeptide revealed after salinity shock is a heat shock protein related to the vertebrate HSP70, Under the impact of stress factor, well acclimated protists mostly spend their own previously accumulated HSP70. A conclusion is made that freshwater protists, living under conditions of increased salinity, appear to be preadapted to changes in environmental factors.},\r\nauthor_keywords={Amoeba proteus;  Freshwater protists;  Heat shock proteins;  Paramecium jenningsi;  Salinity adaptation},\r\ncorrespondence_address1={Plekhanov, A.Yu.; St. Petersburg Nuclear Physics Institute, RAS, St. Petersburg, Russian Federation},\r\nissn={00413771},\r\ncoden={TSITA},\r\npubmed_id={16893060},\r\nlanguage={Russian},\r\nabbrev_source_title={Tsitologiya},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Transcription of TIMP3, DAPK1, and AKR1B10 in squamous-cell lung cancer.\n \n \n \n \n\n\n \n Mashkova, T.; Oparina, N.; Zinov'eva, O.; Kropotova, E.; Dubovaya, V.; Poltaraus, A.; Fridman, M.; Kopantsev, E.; Vinogradova, T.; Zinov'eva, M.; Laktionov, K.; Kasymova, O.; Zborovskaya, I.; Sverdlov, E.; and Kisselev, L.\n\n\n \n\n\n\n Molecular Biology, 40(6): 945-951. 2006.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"Transcription$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mashkova2006945,\r\nauthor={Mashkova, T.D. and Oparina, N.Yu. and Zinov'eva, O.L. and Kropotova, E.S. and Dubovaya, V.I. and Poltaraus, A.B. and Fridman, M.V. and Kopantsev, E.P. and Vinogradova, T.V. and Zinov'eva, M.V. and Laktionov, K.K. and Kasymova, O.T. and Zborovskaya, I.B. and Sverdlov, E.D. and Kisselev, L.L.},\r\ntitle={Transcription of TIMP3, DAPK1, and AKR1B10 in squamous-cell lung cancer},\r\njournal={Molecular Biology},\r\nyear={2006},\r\nvolume={40},\r\nnumber={6},\r\npages={945-951},\r\ndoi={10.1134/S0026893306060148},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-33845627678&doi=10.1134%2fS0026893306060148&partnerID=40&md5=d3c59cdbaa52bd81ce9cab2874a2d1c4},\r\naffiliation={Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russian Federation; State Research Center GosNIIgenetika, Moscow, 113545, Russian Federation; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russian Federation; Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russian Federation},\r\nabstract={Lung cancer is among the most common neoplasms in Russia, the United States, and in Western Europe and is accompanied by changes in the functional activity of many genes. The transcription levels of TIMP3, DAPK1, and AKR1B10 were compared for normal and tumor lung tissues of patients with squamous-cell cancer (SCC) by RT-PCR. A substantial increase in AKR1B10 transcription level was observed in 80% of the tumors. The transcription levels of TIMP3 and DAPK1 were significantly decreased in 76 and 72% of the tumors, respectively. The results implicated the genes in carcinogenesis in SCC, AKR1B10 acting as a potential oncogene, and TIMP3 and DAPK1 acting as potential tumor suppressor genes. It was assumed that dramatic changes in their transcription levels could be used for early diagnosis of SCC. © 2006 Pleiades Publishing, Inc.},\r\nauthor_keywords={Gene transcription;  Lung adenocarcinoma;  Oncogenes;  RT-PCR;  Squamous-cell lung cancer;  Tumor suppressor genes},\r\ncorrespondence_address1={Mashkova, T.D.; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russian Federation; email: mashkova@eimb.ru},\r\nissn={00268933},\r\nlanguage={English},\r\nabbrev_source_title={Mol. Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer.\n \n \n \n \n\n\n \n Mashkova, T.; Oparina, N.; Zinov'eva, O.; Kropotova, E.; Dubovaia, V.; Poltaraus, A.; Fridman, M.; Kopantsev, E.; Vinogradova, T.; Zinov'eva, M.; Laktionov, K.; Kasymova, O.; Zborovskaia, I.; Sverdlov, E.; and Kiselev, L.\n\n\n \n\n\n\n Molekuliarnaia biologiia, 40(6): 1047-1054. 2006.\n cited By 11\n\n\n\n
\n\n\n\n \n \n $\"Transcription$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mashkova20061047,\r\nauthor={Mashkova, T.D. and Oparina, N.I. and Zinov'eva, O.L. and Kropotova, E.S. and Dubovaia, V.I. and Poltaraus, A.B. and Fridman, M.V. and Kopantsev, E.P. and Vinogradova, T.V. and Zinov'eva, M.V. and Laktionov, K.K. and Kasymova, O.T. and Zborovskaia, I.B. and Sverdlov, E.D. and Kiselev, L.L.},\r\ntitle={Transcription TIMP3, DAPk1 and AKR1B10 genes in squamous cell lung cancer},\r\njournal={Molekuliarnaia biologiia},\r\nyear={2006},\r\nvolume={40},\r\nnumber={6},\r\npages={1047-1054},\r\nnote={cited By 11},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847060068&partnerID=40&md5=462034f4b226f0336141061405bd7a66},\r\nabstract={Lung cancer is one of the most frequent neoplasia in the Russia, the United States and Europe. This cancer is associated with functional activity changes of many genes. In the present study TIMP3, DAPK1 and AKR1B10 genes transcription analysis of squamous cell lung cancer specimens was carried out using reverse transcription-PCR. Substantial increasing of AKR1B10 transcription level is revealed in 80% tumor samples. TIMP3 and DAPK1 transcription level is considerably decreased in 76 and 72% tumor specimens, accordingly. These results may point out that all three genes are important for squamous cell lung cancer tumorogenesis while AKR1B10 is potential oncogene whereas TIMP3 and DAPK1 are potential tumor suppressor genes. We suggest that revealed substantial transcription level-changes of investigated genes may be used for oncodiagnostics.},\r\ncorrespondence_address1={Mashkova, T.D.},\r\nissn={00268984},\r\npubmed_id={17209433},\r\nlanguage={Russian},\r\nabbrev_source_title={Mol. Biol. (Mosk.)},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 2005\n \n \n (7)\n \n \n

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\n \n\n \n \n \n \n \n \n Heat shock protein (HSP70) is mediator of the volume transmission of information in rat olfactory cortex.\n \n \n \n \n\n\n \n Mokrushin, A.; and Plekhanov, A.\n\n\n \n\n\n\n Doklady Akademii Nauk, 401(1): 124-128. 2005.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Heat$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mokrushin2005124,\r\nauthor={Mokrushin, A.A. and Plekhanov, A.Yu.},\r\ntitle={Heat shock protein (HSP70) is mediator of the volume transmission of information in rat olfactory cortex},\r\njournal={Doklady Akademii Nauk},\r\nyear={2005},\r\nvolume={401},\r\nnumber={1},\r\npages={124-128},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-27744493722&partnerID=40&md5=a98ba135c3e8d2f0fdcc835a85415dd8},\r\naffiliation={Inst. Fiziologii im. I.P. Pavlova RAN, Sankt-Peterburg, Russian Federation},\r\nabstract={Mediator function of HSP70 was for the first time established in experiments in vitro on male Vistar rat tissue samples. The protein transmits information on cell population preparing to more intense work.},\r\ncorrespondence_address1={Mokrushin, A.A.; Inst. Fiziologii im. I.P. Pavlova RAN, Sankt-Peterburg, Russian Federation},\r\nissn={08695652},\r\ncoden={DAKNE},\r\nlanguage={Russian},\r\nabbrev_source_title={Dokl Akad Nauk},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Specific proteolysis of neuronal protein GAP-43 by calpain: Characterization, regulation, and physiological role.\n \n \n \n \n\n\n \n Zakharov, V.; Bogdanova, M.; and Mosevitsky, M.\n\n\n \n\n\n\n Biokhimiya, 70(8): 1086-1098. 2005.\n cited By 5\n\n\n\n
\n\n\n\n \n \n $\"Specific$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Zakharov20051086,\r\nauthor={Zakharov, V.V. and Bogdanova, M.N. and Mosevitsky, M.I.},\r\ntitle={Specific proteolysis of neuronal protein GAP-43 by calpain: Characterization, regulation, and physiological role},\r\njournal={Biokhimiya},\r\nyear={2005},\r\nvolume={70},\r\nnumber={8},\r\npages={1086-1098},\r\nnote={cited By 5},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-26844562098&partnerID=40&md5=3d358d6e03fa136f7334c7f3078e8c18},\r\naffiliation={Molecular and Radiation Biophysics Div., Petersburg Nuclear Physics Inst., Russian Acad. of Sciences, Gatchina, Leningrad Region, 188300, Russian Federation},\r\nabstract={The mechanism of specific proteolysis of the neuronal protein GAP-43 in axonal terminals has been investigated. In synaptic terminals in vivo and in synaptosomes in vitro GAP-43 is cleaved only at the single peptide bond formed by Ser41; this is within the main effector domain of GAP-43. Proteolysis at this site involves the cysteine calcium-dependent neutral protease calpain. The following experimental evidences support this conclusion: 1) calcium-dependent proteolysis of GAP-43 in synaptosomes is insensitive to selective inhibitor of μ-calpain (PD151746), but it is completely blocked by μ- and m-calpain inhibitor PD150606; 2) GAP-43 proteolysis in the calcium ionophore A23187-treated synaptosomes is activated by millimolar concentration of calcium ions; 3) the pattern of fragmentation of purified GAP-43 by m-calpain (but not by μ-calpain) is identical to that observed in synaptic terminals in vivo. GAP-43 phosphorylated at Ser41 by protein kinase C (PKC) is resistant to the cleavage by calpain. In addition, calmodulin binding to GAP-43 decreases the rate of calpain-mediated GAP-43 proteolysis. Our results indicate that m-calpain-mediated GAP-43 proteolysis regulated by PKC and calmodulin is of physiological relevance, particularly in axonal growth cone guidance. We suggest that the function of the N-terminal fragment of GAP-43 (residues 1-40) formed during cleavage by m-calpain consists in activation of neuronal heterotrimeric GTP-binding protein Go; this results in growth cone turning in response to repulsive signals.},\r\nauthor_keywords={Calmodulin;  Calpain;  Growth cone guidance;  Neuronal protein GAP-43;  Protein kinase C;  Proteolysis;  Synaptic terminals},\r\ncorrespondence_address1={Zakharov, V.V.; Molecular and Radiation Biophysics Div., Petersburg Nuclear Physics Inst., Russian Acad. of Sciences, Gatchina, Leningrad Region, 188300, Russian Federation; email: v.zakharov@vz5518.spb.edu},\r\nissn={03209725},\r\ncoden={BIOHA},\r\nlanguage={Russian},\r\nabbrev_source_title={Biokhim.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Nerve ending \"signal\" proteins GAP-43, MARCKS, and BASP1.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n International Review of Cytology, 245: 245-325. 2005.\n cited By 89\n\n\n\n
\n\n\n\n \n \n $\"Nerve$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Specific proteolysis of neuronal protein GAP-43 by calpain: Characterization, regulation, and physiological role.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Biochemistry (Moscow), 70(8): 897-907. 2005.\n cited By 8\n\n\n\n
\n\n\n\n \n \n $\"Specific$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Heat shock protein HSP70 increases the resistance of cortical cells to glutamate excitotoxicity.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Bulletin of Experimental Biology and Medicine, 140(1): 1-5. 2005.\n cited By 13\n\n\n\n
\n\n\n\n \n \n $\"Heat$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Heat-shock protein (HSP70) as a mediator of volume signal transmission in the olfactory cerebral cortex of rats.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Doklady Biological Sciences, 401(1-6): 81-84. 2005.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"Heat-shock$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n The riboflavin kinase encoding gene ribR of Bacillus subtilis is a part of a 10 kb operon, which is negatively regulated by the yrzC gene product.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n FEMS Microbiology Letters, 243(1): 51-58. 2005.\n cited By 13\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 2004\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n Study of the mechanism for regulating ribR gene activity in Bacillus subtilis.\n \n \n \n \n\n\n \n Solovieva, L.; Kreneva, R.; Errais, L.; Mironov, A.; and Perumov, D.\n\n\n \n\n\n\n Genetika, 40(5): 716-720. 2004.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Study$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Solovieva2004716,\r\nauthor={Solovieva, L.M. and Kreneva, R.A. and Errais, L.L. and Mironov, A.S. and Perumov, D.A.},\r\ntitle={Study of the mechanism for regulating ribR gene activity in Bacillus subtilis},\r\njournal={Genetika},\r\nyear={2004},\r\nvolume={40},\r\nnumber={5},\r\npages={716-720},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-16644395284&partnerID=40&md5=dd81b3141d076f83406e52cfe00d9983},\r\naffiliation={Department of Molecular and Radiation Biophysics, St. Petersburg Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, Leningrad Oblast, 188350, Russian Federation; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow 113545, Russian Federation},\r\nabstract={Analysis of the phenotypic manifestation of inactivation of several genes from the ytlI-ytnM operon containing the ribR gene and results of Northern hybridization showed that the ribR gene does not have the self promoter and is transcribed from the main promoter of the ytlI-ytnM operon. Two sites of single nucleotide substitutions leading to derepresson of ribR gene were identified between the putative main promoter and transcription start of the ytlI-ytnM operon regulatory region.},\r\ncorrespondence_address1={Solovieva, L.M.; Department of Molecular and Radiation Biophysics, St. Petersburg Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, Leningrad Oblast, 188350, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={15272571},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Study of the mechanism for regulating ribR gene activity in Bacillus subtilis.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Russian Journal of Genetics, 40(5): 580-583. 2004.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Study$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 2003\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n Detection of very low concentrations of polypeptide antigens in biogenic media.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Analytical Biochemistry, 320(2): 303-305. 2003.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Detection$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Natural N-terminal fragments of brain abundant myristoylated protein BASP1.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Biochimica et Biophysica Acta - General Subjects, 1622(1): 14-19. 2003.\n cited By 23\n\n\n\n
\n\n\n\n \n \n $\"Natural$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 2002\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Sensing small molecules by nascent RNA: A mechanism to control transcription in bacteria.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Cell, 111(5): 747-756. 2002.\n cited By 427\n\n\n\n
\n\n\n\n \n \n $\"Sensing$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 2001\n \n \n (5)\n \n \n

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\n \n\n \n \n \n \n \n \n Immunological identification of endogenous peptides, secreted by cells of rat olfactory cortex slices.\n \n \n \n \n\n\n \n Mokrushin, A.; and Plekhanov, A.\n\n\n \n\n\n\n Doklady Akademii Nauk, 378(4): 567-570. 2001.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Immunological$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mokrushin2001567,\r\nauthor={Mokrushin, A.A. and Plekhanov, A.Yu.},\r\ntitle={Immunological identification of endogenous peptides, secreted by cells of rat olfactory cortex slices},\r\njournal={Doklady Akademii Nauk},\r\nyear={2001},\r\nvolume={378},\r\nnumber={4},\r\npages={567-570},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0344233189&partnerID=40&md5=7c80d0528704087a3488e890a7e4e1b7},\r\nissn={08695652},\r\ncoden={DAKNE},\r\nabbrev_source_title={Dokl Akad Nauk},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Investigation of the regulation mechanism of the ribC gene activity in bacillus subtilis.\n \n \n \n \n\n\n \n Kreneva, R.; Solovieva, I.; Errais, L.; Mironov, A.; and Perumov, D.\n\n\n \n\n\n\n Genetika, 37(9): 1300-1303. 2001.\n cited By 4\n\n\n\n
\n\n\n\n \n \n $\"Investigation$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva20011300,\r\nauthor={Kreneva, R.A. and Solovieva, I.M. and Errais, L.L. and Mironov, A.S. and Perumov, D.A.},\r\ntitle={Investigation of the regulation mechanism of the ribC gene activity in bacillus subtilis},\r\njournal={Genetika},\r\nyear={2001},\r\nvolume={37},\r\nnumber={9},\r\npages={1300-1303},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035460636&partnerID=40&md5=22768c2fbe8a08e93948c7fd351689f4},\r\naffiliation={Department of Molecular and Radiation Biophysics, St. Petersburg Konstantinov Institute of Nuclear Physics, Russian Academy of Science, Leningrad ablast, 188350, Russian Federation; State Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow, 113545, Russian Federation},\r\nabstract={Sequence analysis of several Bacillus subtilis mutants with increased activity of flavokinase/FAD-synthase and the results of Nothern hybridization showed that the TTGCCG-17n-TACATT motif localized to the C-end of the truB gene is a regulatory region that controls the ribC gene at the level of transcription.},\r\ncorrespondence_address1={Perumov, D.A.; State Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow, 113545, Russian Federation; email: perumov@lbp.ru},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={11642135},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Site-specific calcium-dependent proteolysis of neuronal protein GAP-43.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Neuroscience Research, 39(4): 447-453. 2001.\n cited By 20\n\n\n\n
\n\n\n\n \n \n $\"Site-specific$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Not growth associated protein GAP-43 (B-50), but its fragment GAP-43-3 (B-60) predominates in rat brain during development.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Neuroscience Letters, 297(1): 49-52. 2001.\n cited By 6\n\n\n\n
\n\n\n\n \n \n $\"Not$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n\n \n \n \n \n \n \n Immunological identification of endogenous peptides secreted by surviving slices of rat olfactory cortex.\n \n \n \n \n\n\n \n Mokrushin, A.; and Plekhanov, A.\n\n\n \n\n\n\n Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian, 378: 227-229. 2001.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"Immunological$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mokrushin2001227,\r\nauthor={Mokrushin, A.A. and Plekhanov, A.},\r\ntitle={Immunological identification of endogenous peptides secreted by surviving slices of rat olfactory cortex.},\r\njournal={Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / translated from Russian},\r\nyear={2001},\r\nvolume={378},\r\npages={227-229},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0141957861&partnerID=40&md5=d433b9b3d00b2990f83c5c39edddbe75},\r\naffiliation={Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, Russia, 199034, Russian Federation},\r\ncorrespondence_address1={Mokrushin, A.A.},\r\nissn={00124966},\r\npubmed_id={12918335},\r\nlanguage={English},\r\nabbrev_source_title={Dokl. Biol. Sci.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 2000\n \n \n (4)\n \n \n

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\n \n\n \n \n \n \n \n \n Inactivation of the ypaa gene in bacillus subtilis; analysis of the resulting phenotypic expression.\n \n \n \n \n\n\n \n Kreneva, R.\n\n\n \n\n\n\n Genetika, 36(8): 1166-1168. 2000.\n cited By 14\n\n\n\n
\n\n\n\n \n \n $\"Inactivation$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva20001166,\r\nauthor={Kreneva, R.A.},\r\ntitle={Inactivation of the ypaa gene in bacillus subtilis; analysis of the resulting phenotypic expression},\r\njournal={Genetika},\r\nyear={2000},\r\nvolume={36},\r\nnumber={8},\r\npages={1166-1168},\r\nnote={cited By 14},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034241199&partnerID=40&md5=9d1486cc7af5509d12752639c50f882b},\r\naffiliation={Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, St. Petersburg, Gatchina, 188350, Russian Federation},\r\nabstract={After inactivation of the ypaA gene in Bacillus subtilis, the phenotypic pattern obtained showed that this gene controls a system for active flavin transport and, possibly, riboflavin excretion under the conditions of constitutive synthesis.},\r\ncorrespondence_address1={Kreneva, R.A.; Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, St. Petersburg, Gatchina, 188350, Russian Federation; email: pnpi@lnpi.spb.su},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={11033791},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Enhanced Level of Site-Specific Proteolysis of GAP-43 Protein during Early Stages of Brain Development.\n \n \n \n \n\n\n \n Mosevitsky, M.; Konovalova, E.; Bichevaya, N.; and Klementiev, B.\n\n\n \n\n\n\n Biochemistry (Moscow), 65(10): 1153-1156. 2000.\n cited By 5\n\n\n\n
\n\n\n\n \n \n $\"Enhanced$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mosevitsky20001153,\r\nauthor={Mosevitsky, M.I. and Konovalova, E.S. and Bichevaya, N.K. and Klementiev, B.I.},\r\ntitle={Enhanced Level of Site-Specific Proteolysis of GAP-43 Protein during Early Stages of Brain Development},\r\njournal={Biochemistry (Moscow)},\r\nyear={2000},\r\nvolume={65},\r\nnumber={10},\r\npages={1153-1156},\r\nnote={cited By 5},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034297206&partnerID=40&md5=b462a526bc02b4c0c63449b18e6f815d},\r\naffiliation={Petersburg Inst. of Nuclear Physics, Russian Academy of Sciences, Gatchina, Leningrad Region, 188350, Russian Federation; Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. Akademika Pavlova 12, St. Petersburg 197376, Russian Federation},\r\nabstract={GAP-43 protein of nerve terminals (B-50, F1, F57, pp46, neuromodulin) is thought to be one of key proteins involved in the control of outgrowth of neuntes, release of neuromediators, synapse plasticity, etc. GAP-43 is usually considered as a whole protein. Along with the intact protein, nerve cells also contain two large native fragments of GAP-43 deprived of four or of about forty N-terminal amino acid residues (GAP-43-2 and GAP-43-3, respectively). The full-length GAP-43 is predominant in the mature brain. However, the ratio of the full-length protein and its fragments can vary under different physiological conditions. Changes in the GAP-43 proteins (the full-length protein and its fragments) were studied during embryonal and postnatal development of rat brain. The GAP-43 proteins were found to be expressed not later than on the 12-13th day of embryogenesis. Then their contents increased, and, until the 10th day after birth, GAP-43-3 dominated rather than the full-length protein. It is suggested that during this period the activity of a specific protease, which cleaves the N-terminal peptide of about 40 residues from the full-length GAP-43 molecule, is increased. The cleavage occurs in the region responsible for the interaction of GAP-43 with calmodulin. In the full-length molecule, this region is responsible also for the recognition of Ser4l residue by protein kinase C during phosphorylation. Another functionally important region that determines, in particular, the attachment of GAP-43 to the plasma membrane is cleaved from the main pan of the molecule together with the N-terminal peptide. Thus, the specific fragmentation of GAP-43 that depends on developmental stage should be considered as a controlled structural rearrangement fundamentally affecting the functions of this protein.},\r\nauthor_keywords={Gap-43 protein of nerve terminals;  Neuroontogenesis;  Site-specific proteolysis},\r\ncorrespondence_address1={Mosevitsky, M.I.; Petersburg Inst. of Nuclear Physics, Russian Academy of Sciences, Gatchina, Leningrad Region, 188350, Russian Federation; email: mm5768@mm5768.spb.edu},\r\nissn={00062979},\r\ncoden={BIORA},\r\npubmed_id={11092958},\r\nlanguage={English},\r\nabbrev_source_title={Biochemistry Moscow},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Inactivation of the ypaA gene in Bacillus subtilis; Analysis of the resulting phenotypic expression.\n \n \n \n \n\n\n \n Kreneva, R.; Gel'fand, M.; Mironov, A.; Yomantas, Y.; Kozlov, Y.; Mironov, A.; and Perumov, D.\n\n\n \n\n\n\n Russian Journal of Genetics, 36(8): 972-974. 2000.\n cited By 12\n\n\n\n
\n\n\n\n \n \n $\"Inactivation$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva2000972,\r\nauthor={Kreneva, R.A. and Gel'fand, M.S. and Mironov, A.A. and Yomantas, Yu.A. and Kozlov, Yu.I. and Mironov, A.S. and Perumov, D.A.},\r\ntitle={Inactivation of the ypaA gene in Bacillus subtilis; Analysis of the resulting phenotypic expression},\r\njournal={Russian Journal of Genetics},\r\nyear={2000},\r\nvolume={36},\r\nnumber={8},\r\npages={972-974},\r\nnote={cited By 12},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0001302597&partnerID=40&md5=a4fb01dbc81cd55590ccb809736f87d2},\r\naffiliation={Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, St. Petersburg, Gatchina, 188350, Russian Federation; Institute of Genetics and Selection of Industrial Microorganisms, Moscow, 113545, Russian Federation; Ajinomoto-Genetika Research Institute, Moscow, 113545, Russian Federation},\r\nabstract={After inactivation of the ypaA gene in Bacillus subtilis, the phenotypic pattern obtained showed that this gene controls a system for active flavin transport and, possibly, riboflavin excretion under the conditions of constitutive synthesis. © 2000 MAIK "Nauka/Interperiodica".},\r\ncorrespondence_address1={Kreneva, R.A.; Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, St. Petersburg, Gatchina, 188350, Russian Federation; email: pnpi@lnpi.spb.su},\r\nissn={10227954},\r\nlanguage={English},\r\nabbrev_source_title={Russ. J. Gen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n A minimal model of energetic coupling of cotransport and anion-exchange transfer mechanisms in biological membranes.\n \n \n \n \n\n\n \n Orlov, Y.; Rebane, Y.; and Rebane, E.\n\n\n \n\n\n\n Biofizika, 45(5): 863. 2000.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"A$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Orlov2000863,\r\nauthor={Orlov, Yu.N. and Rebane, Yu.T. and Rebane, E.N.},\r\ntitle={A minimal model of energetic coupling of cotransport and anion-exchange transfer mechanisms in biological membranes},\r\njournal={Biofizika},\r\nyear={2000},\r\nvolume={45},\r\nnumber={5},\r\npages={863},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0039339393&partnerID=40&md5=a87a0703c522ee7adbd07c15e2bbe7af},\r\naffiliation={St. Petersburg Inst. of Nucl. Phys., Russian Academy of Sciences, Gatchina, 188350, Russian Federation; Ioffe Physicotechnical Institute, Russian Academy of Sciences, Politekhnicheskaya ul. 26, St Petersburg, 194021, Russian Federation; Sechenov Inst. Evol. Physiol. B., Russian Academy of Sciences, pr. M. Toreza 44, St. Petersburg, 194223, Russian Federation},\r\nabstract={A minimal model for the coupling of fluxes of two different anions was constructed, in which one anion Y, is transferred by both the cotransport and anion-exchange pathways, whereas the other anion, Z, only by the anion-exchange mechanism. The possibilities of the model for describing the cooperativity of cotransport and anion-exchange pathways are demonstrated by using the computer simulation approach. It is shown that the energetic coupling of Y and Z anion fluxes becomes possible when the following conditions are fulfilled: (1) The inward-directed flux of Y by the cotransport pathway exceeds its anion-exchange flux directed outward; (2) the reorientation probability of the Y-loaded anion-exchanger is higher than that of the unloaded exchanger.},\r\nauthor_keywords={Anions;  Energetic coupling;  Mathematical model;  Membranes;  Transport fluxes},\r\ncorrespondence_address1={Orlov, Yu.N.; St. Petersburg Inst. of Nucl. Phys., Russian Academy of Sciences, Gatchina, 188350, Russian Federation},\r\npublisher={Maik Nauka-Interperiodica Publishing},\r\nissn={00063029},\r\ncoden={BIOFA},\r\npubmed_id={11094713},\r\nlanguage={Russian},\r\nabbrev_source_title={Biofizika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1999\n \n \n (5)\n \n \n

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\n \n\n \n \n \n \n \n \n Antiviral activity of poly(A)·poly(U) duplexes modified with cis-diammine dichloroplatinum (II).\n \n \n \n \n\n\n \n Aksenov, O.; Platonova, G.; and Timkovsky, A.\n\n\n \n\n\n\n Antibiotiki i Khimioterapiya, 44(6): 12-15. 1999.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Antiviral$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Aksenov199912,\r\nauthor={Aksenov, O.A. and Platonova, G.A. and Timkovsky, A.L.},\r\ntitle={Antiviral activity of poly(A)·poly(U) duplexes modified with cis-diammine dichloroplatinum (II)},\r\njournal={Antibiotiki i Khimioterapiya},\r\nyear={1999},\r\nvolume={44},\r\nnumber={6},\r\npages={12-15},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032618973&partnerID=40&md5=d9031f39714de853585bf07b5b4bd1ec},\r\nabstract={Polyribonucleotide duplex poly(A)·poly(U) was modified with cis-diammine dichloroplatinum (II) (cis-DDP). It was shown that the antiinfluenza protective activity of the modified duplex in mice increased with the degree of modification (rb) rising up to 0.2. The effect was different from that for poly(I)·poly(C) and poly(G)·poly(C). The interferon titers in the murine brain increased in parallel with increasing of the antiviral activity. It was assumed that the structural specificity of the poly(A)·poly(U) duplex was responsible for the phenomenon and that cis-DDP interaction with N(7) atoms of the adenine heterocycles blocked the "abnormal" Hoogsteen pairing of adenines with uracils. As a result the antiviral activity increased because of lowering the quantity of the intramolecular defects and increasing the length of the regular double-stranded regions.},\r\nauthor_keywords={Antiviral activity;  cis-diammine dichloroplatinum (II);  Polyribonucleotide duplexes},\r\nissn={02352990},\r\ncoden={ANKHE},\r\npubmed_id={10422572},\r\nlanguage={Russian},\r\nabbrev_source_title={Antibiot. Khimioter.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Broadening of organospecificity of the action of polynucleotide interferon inductors.\n \n \n \n \n\n\n \n Aksenov, O.; Platonova, G.; and Timkovsky, A.\n\n\n \n\n\n\n Antibiotiki i Khimioterapiya, 44(9): 10-12. 1999.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Broadening$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Aksenov199910,\r\nauthor={Aksenov, O.A. and Platonova, G.A. and Timkovsky, A.L.},\r\ntitle={Broadening of organospecificity of the action of polynucleotide interferon inductors},\r\njournal={Antibiotiki i Khimioterapiya},\r\nyear={1999},\r\nvolume={44},\r\nnumber={9},\r\npages={10-12},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032613218&partnerID=40&md5=d878cbd5071991b2604813e4f27cc87d},\r\nabstract={Interferon titers in the blood and brain of mice and their protection from the herpes virus were compared after the animal exposure to poly(G)·poly(C) duplex, both native and modified with cis-diammine dichloroplatinum (II). It was shown that the duplex platination especially at the level of the poly(G) strand resulted in sharp rising of the interferon titers in the extracts of the animal brain and rearrangement of the types of interferon induced in the brain to predominance of γ-interferon. The interferonogenesis indices correlated with the duplex protective activity against the herpes virus. It was concluded that the platinum binding could increase the membrane specificity of the duplex and stimulate its penetration through the hematoencephalic barrier. Possible structural changes in the duplex under the action of platinum (II) resulting in the observed effect are discussed.},\r\nauthor_keywords={Cis-diammine dichloroplatinum (II);  Herpes virus;  Interferon inductors;  Poly(G)·poly(C)},\r\nissn={02352990},\r\ncoden={ANKHE},\r\npubmed_id={10511902},\r\nlanguage={Russian},\r\nabbrev_source_title={Antibiot. Khimioter.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Analysis of the Operator-Like Structure that Regulates the Bacillus subtilis ribC Gene Activity.\n \n \n \n \n\n\n \n Kreneva, R.; Polanuer, B.; Solov'eva, I.; and Perumov, D.\n\n\n \n\n\n\n Russian Journal of Genetics, 35(3): 335-337. 1999.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Analysis$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva1999335,\r\nauthor={Kreneva, R.A. and Polanuer, B.M. and Solov'eva, I.M. and Perumov, D.A.},\r\ntitle={Analysis of the Operator-Like Structure that Regulates the Bacillus subtilis ribC Gene Activity},\r\njournal={Russian Journal of Genetics},\r\nyear={1999},\r\nvolume={35},\r\nnumber={3},\r\npages={335-337},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0347031212&partnerID=40&md5=45c51adb80f6c233ca75eb03947c83a0},\r\naffiliation={Department of Molecular Biophysics, Konstantinov Inst. of Nucl. Physics, Russ. Academy of Sciences, Gatchina, St. Petersburg 188350, Russian Federation; State Res. Inst. Genet. Sel. I., Moscow 113545, Russian Federation},\r\nabstract={A point mutation (C → A substitution) in the -35 region of a putative promoter-operator site TTGCCG-17n-TACATT results in a more than 25-fold increase in the activity of ribC gene encoding the bifunctional enzyme - flavokinase/FAD-synthase - in Bacillus subtilis.},\r\ncorrespondence_address1={Kreneva, R.A.; Department of Molecular Biophysics, Konstantinov Inst. of Nucl. Physics, Russ. Academy of Sciences, Gatchina, St. Petersburg 188350, Russian Federation; email: pnpi@lnpi.spb.su},\r\nissn={10227954},\r\nlanguage={English},\r\nabbrev_source_title={Russ. J. Gen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Analysis of the operator-like structure that regulates the bacillus subtilis ribC gene activity.\n \n \n \n \n\n\n \n Kreneva, R.; Polanuer, B.; Solov'Eva, M.; and Perumov, D.\n\n\n \n\n\n\n Genetika, 35(3): 409-411. 1999.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Analysis$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Kreneva1999409,\r\nauthor={Kreneva, R.A. and Polanuer, B.M. and Solov'Eva, M. and Perumov, D.A.},\r\ntitle={Analysis of the operator-like structure that regulates the bacillus subtilis ribC gene activity},\r\njournal={Genetika},\r\nyear={1999},\r\nvolume={35},\r\nnumber={3},\r\npages={409-411},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033088530&partnerID=40&md5=6d1fa5d3fa862df76e01c15e478472fb},\r\naffiliation={Department of Molecular Ana Radiation Biophysics, Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, St. Petersburg, 188350, Russian Federation; State Research Institute of Genetics, Selection of Industrial Microorganisms, Moscow, 113545, Russian Federation},\r\nabstract={A point mutation (C -A substitution) in the -35 region of a putative promoter-operator site TTGCCG-17nTACATT results in a more than 25-fold increase in the activity of rihC gene encoding the bifunctional enzyme-flavokinase/FAD-synthase-in Bacillus subtilis.},\r\ncorrespondence_address1={Kreneva, R.A.; State Research Institute of Genetics, Selection of Industrial Microorganisms, Moscow, 113545, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={10368790},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n The ribR gene encodes a monofunctional riboflavin kinase which is involved in regulation of the Bacillus subtilis riboflavin operon.\n \n \n \n \n\n\n \n Solovieva, I.; Kreneva, R.; Leak, D.; and Perumov, D.\n\n\n \n\n\n\n Microbiology, 145(1): 67-73. 1999.\n cited By 41\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Solovieva199967,\r\nauthor={Solovieva, I.M. and Kreneva, R.A. and Leak, D.J. and Perumov, D.A.},\r\ntitle={The ribR gene encodes a monofunctional riboflavin kinase which is involved in regulation of the Bacillus subtilis riboflavin operon},\r\njournal={Microbiology},\r\nyear={1999},\r\nvolume={145},\r\nnumber={1},\r\npages={67-73},\r\ndoi={10.1099/13500872-145-1-67},\r\nnote={cited By 41},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032924988&doi=10.1099%2f13500872-145-1-67&partnerID=40&md5=1a836a090fd09129e77b2eeeb00ca1ad},\r\naffiliation={Dept. of Molec. and Radiat. Biophys., Petersburg Nuclear Physics, Inst. of the Russ. Acad. of Sciences, Gatchina, Leningrad District 188350, Russian Federation; Department of Biochemistry, Imp. Coll. Sci., Technol. and Med., London SW7 2AY, United Kingdom},\r\nabstract={A 3.5 kb EcoRI-BamHI fragment of Bacillus subtilis chromosomal DNA carrying the ribR gene, involved in regulation of the B. subtilis riboflavin operon, was cloned in the B. subtilis-Escherichia coli shuttle vector pCB20. DNA sequence analysis of this fragment revealed several ORFs, one of which encodes a polypeptide of 230 amino acids with up to 45% sequence identity with FAD synthetases from a number of micro-organisms, such as Corynebacterium ammoniagenes, E. coli and Pseudomonas fluorescens, and also to the ribC gene product of B. subtilis. The ribR gene was amplified by PCR, cloned and expressed in E. coli. Measurement of flavokinase activity in cell extracts demonstrated that ribR encodes a monofunctional flavokinase which converts riboflavin into FMN but not to FAD, and is specific for the reduced form of riboflavin.},\r\nauthor_keywords={Bacillus subtilis;  Flavinogenesis;  Flavokinase;  Operon regulation;  Riboflavin},\r\ncorrespondence_address1={Solovieva, I.M.; Dept Molecular Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina, Leningrad District 188350, Russian Federation; email: solovyov@math-atom.pti.spb.su},\r\npublisher={Society for General Microbiology},\r\nissn={13500872},\r\ncoden={MROBE},\r\npubmed_id={10206712},\r\nlanguage={English},\r\nabbrev_source_title={Microbiology},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1998\n \n \n (4)\n \n \n

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\n \n\n \n \n \n \n \n \n The mechanism of coupling of the organic anion exchange to Na+/dicarboxylate symport in basolateral membrane vesicles.\n \n \n \n \n\n\n \n Rebane, E.; Orlov, Y.; Kazbekov, E.; Lyubimov, Y.; and Bulat, M.\n\n\n \n\n\n\n Biologicheskie Membrany, 15(1): 47. 1998.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Rebane199847,\r\nauthor={Rebane, E.N. and Orlov, Yu.N. and Kazbekov, E.N. and Lyubimov, Y. and Bulat, M.N.},\r\ntitle={The mechanism of coupling of the organic anion exchange to Na+/dicarboxylate symport in basolateral membrane vesicles},\r\njournal={Biologicheskie Membrany},\r\nyear={1998},\r\nvolume={15},\r\nnumber={1},\r\npages={47},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0040579124&partnerID=40&md5=708a35df418dbc6787afeb5e8bfea39d},\r\naffiliation={St. Petersburg Inst. of Nucl. Phys., Russian Academy of Sciences, Gatchina, Russian Federation; Sechenov Inst. Evol. Physiol. B., Russian Academy of Sciences, St. Petersburg, Russian Federation},\r\nabstract={The mechanism of energetic coupling of the organic anion transport to the gradient of Na+ has been investigated in basolateral membrane vesicles from the rat kidney cortex. The uphill transport of p-aminohippuric and uric acids was shown to occur upon the coupling of Na"/α-ketoglutarate sytnport and organic anion/α-ketoglutarate exchange. Based on the of differences in the dynamics of p-aminohippurate and uric acid uptake by the vesicles, it was proposed that anion exchange is a limiting step of the coupling mechanism.},\r\ncorrespondence_address1={Rebane, E.N.; Sechenov Inst. Evol. Physiol. B., Russian Academy of Sciences, St. Petersburg, Russian Federation},\r\nissn={02334755},\r\nlanguage={English},\r\nabbrev_source_title={Biol. Membr.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Subcloning and the biochemical identification of the bacillus subtilis ribR gene.\n \n \n \n \n\n\n \n Solovieva, I.; Kreneva, R.; Polanuer, B.; Kozlov, Y.; and Perumov, D.\n\n\n \n\n\n\n Genetika, 34(6): 839-842. 1998.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"Subcloning$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Solovieva1998839,\r\nauthor={Solovieva, I.M. and Kreneva, R.A. and Polanuer, B.M. and Kozlov, Yu.I.. and Perumov, D.A.},\r\ntitle={Subcloning and the biochemical identification of the bacillus subtilis ribR gene},\r\njournal={Genetika},\r\nyear={1998},\r\nvolume={34},\r\nnumber={6},\r\npages={839-842},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032087653&partnerID=40&md5=9db53f6a5e4796f9ffc1eae4ed9f8fd9},\r\naffiliation={Dept. of Molec. and Radiat. Biophys., Konstantinov Inst. of Nucl. Physics, Russ. Academy of Sciences, Gatchina, Leningrad ohlast', 188350, Russian Federation; State Res. Inst. Genet. Sel. Indust., Moscow, 113545, Russian Federation},\r\nabstract={Russia The PCR copy of the ribR gene of Bacillus subtilis was subcloned in Escherichia coli cells under the control of the phage T7 inducible promoter. The polypeptide of 26 kDa corresponding to the 690-bp gene is the product of the ribR gene. The protein encoded by the ribR gene is flavokinase, and the riboflavin-reduced form is the substrate for it.},\r\ncorrespondence_address1={Solovieva, I.M.; Dept. of Molec. and Radiat. Biophys., Konstantinov Inst. of Nucl. Physics, Russ. Academy of Sciences, Gatchina, Leningrad ohlast', 188350, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={9719928},\r\nlanguage={English; Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

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\n \n\n \n \n \n \n \n \n The mechanism of coupling of the organic anion exchange to Na+-dicarboxylate symport in basolateral membrane vesicles.\n \n \n \n \n\n\n \n Rebane, E.; Orlov, Y.; Kazbekov, E.; Lyubimov, Y.; and Bulat, M.\n\n\n \n\n\n\n Membrane and Cell Biology, 12(1): 51-56. 1998.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Rebane199851,\r\nauthor={Rebane, E.N. and Orlov, Y.N. and Kazbekov, E.N. and Lyubimov, Y. and Bulat, M.N.},\r\ntitle={The mechanism of coupling of the organic anion exchange to Na+-dicarboxylate symport in basolateral membrane vesicles},\r\njournal={Membrane and Cell Biology},\r\nyear={1998},\r\nvolume={12},\r\nnumber={1},\r\npages={51-56},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031739452&partnerID=40&md5=c262e345a14964f5a6b8dee5e93f3bc4},\r\naffiliation={Sechenov Inst Evolutionary Physiol, Russian Academy of Sciences, St. Petersburg, Russian Federation},\r\nabstract={The rates of p-aminohippurate (PAH) and of uric acid uptake by basolateral membrane vesicles isolated from proximal tubules of rat kidney have been investigated. Accumulation of both substrates against the concentration gradient within the vesicles was shown to occur in the presence of α-ketoglutarate (α-KG) and Na+ gradient in the incubation medium. The mechanism of the coupling between Na+-dicarboxylate symport and organic anion transport is discussed based on the differences between the rates of PAH and of uric acid uptake. It is proposed that the limiting step of coupling between two transporters is the step of α-KG-organic anion exchange.},\r\ncorrespondence_address1={Rebane, E.N.; Sechenov Inst Evolutionary Physiol, Russian Academy of Sciences, St. Petersburg, Russian Federation},\r\nissn={10236597},\r\ncoden={MCBIE},\r\npubmed_id={9829258},\r\nlanguage={English},\r\nabbrev_source_title={Membr. Cell Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

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\n \n\n \n \n \n \n \n \n Subcloning and the Biochemical Identification of the Bacillus subtilis ribR gene.\n \n \n \n \n\n\n \n Solovieva, I.; Kreneva, R.; Polanuer, B.; Kozlov, Y.; and Perumov, D.\n\n\n \n\n\n\n Russian Journal of Genetics, 34(6): 693-695. 1998.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Subcloning$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Solovieva1998693,\r\nauthor={Solovieva, I.M. and Kreneva, R.A. and Polanuer, B.M. and Kozlov, Yu.I. and Perumov, D.A.},\r\ntitle={Subcloning and the Biochemical Identification of the Bacillus subtilis ribR gene},\r\njournal={Russian Journal of Genetics},\r\nyear={1998},\r\nvolume={34},\r\nnumber={6},\r\npages={693-695},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-1842761756&partnerID=40&md5=5cea26e874dabd75c8ccad91b6cb3d84},\r\naffiliation={Dept. of Molec. and Radiat. Biophys., Konstantinov Inst. of Nucl. Physics, Russian Academy of Sciences, Gatchina, Leningrad oblast, 188350, Russian Federation; State Res. Inst. Genet. Sel. I., Moscow, 113545, Russian Federation},\r\nabstract={The PCR copy of the ribR gene of Bacillus subtilis was subcloned in Escherichia coli cells under the control of the phage T7 inducible promoter. The polypeptide of 26 kDa corresponding to the 690-bp gene is the product of the ribR gene. The protein encoded by the ribR gene is flavokinase, and the riboflavin-reduced form is the substrate for it.},\r\ncorrespondence_address1={Solovieva, I.M.; Dept. of Molec. and Radiat. Biophys., Konstantinov Inst. of Nucl. Physics, Russian Academy of Sciences, Gatchina, Leningrad oblast, 188350, Russian Federation},\r\nissn={10227954},\r\nlanguage={English},\r\nabbrev_source_title={Russ. J. Gen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1997\n \n \n (11)\n \n \n

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\n \n\n \n \n \n \n \n \n Native complex of membrane lipids and myristoylated protein basp1.\n \n \n \n \n\n\n \n Plekhanov, A.; Alikova, S.; and Mosevitsky, M.\n\n\n \n\n\n\n FASEB Journal, 11(9): A993. 1997.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Native$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Plekhanov1997,\r\nauthor={Plekhanov, A.Y. and Alikova, S.L. and Mosevitsky, M.I.},\r\ntitle={Native complex of membrane lipids and myristoylated protein basp1},\r\njournal={FASEB Journal},\r\nyear={1997},\r\nvolume={11},\r\nnumber={9},\r\npages={A993},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750123940&partnerID=40&md5=d667c9f6ece0136bb64cff0294a25aaa},\r\naffiliation={Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina, Petersburg, Russian Federation; Department of Biochemistry, Petersburg State University, Petersburg, Russian Federation},\r\nabstract={Myristoylated protein BASP1 is abundant in nerve tissue as well as in testis and kidney. Some physico-chemical properties of BASP1 and of prominent neuronal protein GAP-43 (B-50, pp46, F1, neuromodulin) are similar. In neurons, BASP1 similarly to GAP-43 is mainly attached to a membrane in axonal endings (M.Mosevitsky et al. Neurosci. Res. 1994, v.19,223-228; - Biochimie, in press). In this study, we show that in tissue homogenates or cell membrane preparations treated with alkali (pH 12), BASP1 (but not GAP-43) is associated with lipids. This complex was purified by gel exclusion chromatography in a Toyopearl HW-55F column equilibrated with 0.01 N NaOH. At neutral pH the complex is insoluble. BASP1 can be solubilized from precipitated complex by extraction with 5% perchloric acid-l% Triton X-100 or by delipidation with chlorophorm-methanot mixture (2:1). We hypothesize that in the preparations of alkali dissociated cell membranes, BASP1 (possibly, its fat component) remains in contact with the nearest lipids. Characterization of these lipids will be of value for understanding the mode of BASPl-membrane interaction. This study is supported by RFFI grant 97-04-50128.},\r\ncorrespondence_address1={Plekhanov, A.Y.; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Russian Academy of Sciences, Gatchina, Petersburg, Russian Federation},\r\nissn={08926638},\r\ncoden={FAJOE},\r\nlanguage={English},\r\nabbrev_source_title={FASEB J.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Mechanisms of secretion of toxic organic anions in mammalian kidneys.\n \n \n \n \n\n\n \n Orlov, Y.\n\n\n \n\n\n\n Biologicheskie Membrany, 14(4): 348-350. 1997.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Mechanisms$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Orlov1997348,\r\nauthor={Orlov, Yu.N.},\r\ntitle={Mechanisms of secretion of toxic organic anions in mammalian kidneys},\r\njournal={Biologicheskie Membrany},\r\nyear={1997},\r\nvolume={14},\r\nnumber={4},\r\npages={348-350},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0039972298&partnerID=40&md5=0c5f5190d3c95e1bf638b114c7821ab0},\r\naffiliation={St. Petersburg Inst. of Nucl. Phys., Russian Academy of Sciences, St. Petersburg, Russian Federation},\r\nabstract={This short review is dedicated to the studies of the mechanisms of organic anion secretion in renal proximal tubules. Particular attention is given to the energetic coupling of p-aminohippurate transport to inorganic anion gradients generated acros both basolateral and brush-border membranes. The coupling is considered to be a consequence of the combined operation of the co-transport and anion-exchange mechanisms. A possible coexistence of several organic anion pathways with overlapping substrate specificity and (or) energetic dependence on the total ion gradient are suggested. The problem of identification of transporters involved in the organic anion secretion is discussed.},\r\ncorrespondence_address1={Orlov, Yu.N.; St. Petersburg Inst. of Nucl. Phys., Russian Academy of Sciences, St. Petersburg, Russian Federation},\r\nissn={02334755},\r\nlanguage={English},\r\nabbrev_source_title={Biol. Membr.},\r\ndocument_type={Review},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Mechanisms of secretion of toxic organic anions in mammalian kidneys.\n \n \n \n \n\n\n \n Orlov, Y.\n\n\n \n\n\n\n Membrane and Cell Biology, 11(4): 417-429. 1997.\n cited By 4\n\n\n\n
\n\n\n\n \n \n $\"Mechanisms$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Orlov1997417,\r\nauthor={Orlov, Yu.N.},\r\ntitle={Mechanisms of secretion of toxic organic anions in mammalian kidneys},\r\njournal={Membrane and Cell Biology},\r\nyear={1997},\r\nvolume={11},\r\nnumber={4},\r\npages={417-429},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031404450&partnerID=40&md5=7e45b79e667695ba1b66afee14673b54},\r\naffiliation={St. Petersburg Inst. Nuclear Physics, Russian Academy of Sciences, St. Petersburg, 188350, Russian Federation},\r\nabstract={This short review considers the mechanisms of organic anion secretion in renal proximal tubules. Particular attention is given to the energy coupling of p-aminohippurate transport to inorganic anion gradients generated across both basolateral and brush-border membranes. The coupling is considered to be a consequence of the combined operation of the co-transport and anion-exchange mechanisms. A possible coexistence of several organic anion pathways with overlapping substrate specificity and/or energetic dependence of the total ion gradient are suggested. The problem of identification of transporters involved in organic anion secretion is discussed.},\r\ncorrespondence_address1={Orlov, Yu.N.; St. Petersburg Inst. Nuclear Physics, Russian Academy of Sciences, St. Petersburg, 188350, Russian Federation; email: orlov@bird.macro.ru},\r\nissn={10236597},\r\ncoden={MCBIE},\r\npubmed_id={9553930},\r\nlanguage={English},\r\nabbrev_source_title={Membr. Cell Biol.},\r\ndocument_type={Review},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n P].\n \n \n \n \n\n\n \n Kreneva, R.; Kozlov, Y.; and Perumov, D.\n\n\n \n\n\n\n Genetika, 33(5): 599-603. 1997.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"P]$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva1997599,\r\nauthor={Kreneva, R.A. and Kozlov, Y.I. and Perumov, D.A.},\r\ntitle={P]},\r\njournal={Genetika},\r\nyear={1997},\r\nvolume={33},\r\nnumber={5},\r\npages={599-603},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031133232&partnerID=40&md5=cfc3ad7927e7298c54ad851c4df51eac},\r\naffiliation={Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, Leningradskaya ablast, 188350, Russian Federation},\r\nabstract={Assessment of specific activity of riboflavin synthase and the level of riboflavin accumulation in strains with a 110-nucleotide deletion in the regulatory region of the riboflavin operon showed that this deletion specified semi-constitutive expression of the operon. This was assumed to be connected with the elimination of three nucleotides from a potential transcription antiterminator.},\r\ncorrespondence_address1={Kreneva, R.A.; Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, Leningradskaya ablast, 188350, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={9273316},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n The Primary Structure of an Additional Regulatory Domain of the Bacillus subtilis Riboflavin Operon.\n \n \n \n \n\n\n \n Gusarov, I.; Solov'eva, I.; Iomantas, Y.; Kreneva, R.; Kozlov, Y.; and Perumov, D.\n\n\n \n\n\n\n Russian Journal of Genetics, 33(9): 1129-1132. 1997.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Gusarov19971129,\r\nauthor={Gusarov, I.I. and Solov'eva, I.M. and Iomantas, Yu.A.-V. and Kreneva, R.A. and Kozlov, Yu.I. and Perumov, D.A.},\r\ntitle={The Primary Structure of an Additional Regulatory Domain of the Bacillus subtilis Riboflavin Operon},\r\njournal={Russian Journal of Genetics},\r\nyear={1997},\r\nvolume={33},\r\nnumber={9},\r\npages={1129-1132},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542735100&partnerID=40&md5=a6772367af19ab47987920327c00d25a},\r\naffiliation={State Res. Inst. Genet. Sel. I., Moscow, 113545, Russian Federation; Konstantinov Inst. of Nucl. Physics, Russian Academy of Sciences, Leningradskaya oblast, 188350, Russian Federation},\r\nabstract={The sequencing of a 3.5 kb EcoRI-BamHI fragment located in the 236° region of the Bacillus subtilis chromosome revealed a 690-bp long open reading frame, partly similar in amino acid composition to flavokinases/FAD synthases from several microorganisms. The discovered sequence can be identified with the gene ribR, an auxiliary regulatory gene of the riboflavin operon of Bacillus subtilis.},\r\ncorrespondence_address1={Gusarov, I.I.; State Res. Inst. Genet. Sel. I., Moscow, 113545, Russian Federation},\r\nissn={10227954},\r\nlanguage={English},\r\nabbrev_source_title={Russ. J. Gen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Riboflavin biosynthesis genes of bacillus amyloliquefaciens: Primary structure, arrangement, and regulation.\n \n \n \n \n\n\n \n Gusarov, J.; Kreneva, R.; Podchernyaev, D.; Lomantas, Y.; Abalakina, E.; Stoinova, N.; Perumov, D.; and Kozlov, Y.\n\n\n \n\n\n\n Molekulyarnaya Biologiya, 31(3): 446-453. 1997.\n cited By 13\n\n\n\n
\n\n\n\n \n \n $\"Riboflavin$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Gusarov1997446,\r\nauthor={Gusarov, J.J. and Kreneva, R.A. and Podchernyaev, D.A. and Lomantas, Yu.V. and Abalakina, E.G. and Stoinova, N.V. and Perumov, D.A. and Kozlov, Yu.I.},\r\ntitle={Riboflavin biosynthesis genes of bacillus amyloliquefaciens: Primary structure, arrangement, and regulation},\r\njournal={Molekulyarnaya Biologiya},\r\nyear={1997},\r\nvolume={31},\r\nnumber={3},\r\npages={446-453},\r\nnote={cited By 13},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031138229&partnerID=40&md5=9956642813697e13aacebcba08c578bf},\r\nissn={00268984},\r\ncoden={MOBIB},\r\npubmed_id={9297088},\r\nlanguage={Russian},\r\nabbrev_source_title={Mol. Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Primary structure and functional activity of the bacillus subtilis gene ribC.\n \n \n \n \n\n\n \n Gusarov; Kreneva, R.; Rybak, K.; Podchemyaev, D.; Lomantas, Y.; Kolibaba, L.; Polanuer, B.; Kozlov, Y.; and Perumov, D.\n\n\n \n\n\n\n Molekulyarnaya Biologiya, 31(5): 820-825. 1997.\n cited By 15\n\n\n\n
\n\n\n\n \n \n $\"Primary$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Gusarov1997820,\r\nauthor={Gusarov and Kreneva, R.A. and Rybak, K.V. and Podchemyaev, D.A. and Lomantas, Yu.V. and Kolibaba, L.G. and Polanuer, B.M. and Kozlov, Yu.I. and Perumov, D.A.},\r\ntitle={Primary structure and functional activity of the bacillus subtilis gene ribC},\r\njournal={Molekulyarnaya Biologiya},\r\nyear={1997},\r\nvolume={31},\r\nnumber={5},\r\npages={820-825},\r\nnote={cited By 15},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031217883&partnerID=40&md5=d566b7057ca32ba148490dfb4001abf7},\r\nissn={00268984},\r\ncoden={MOBIB},\r\npubmed_id={9454067},\r\nlanguage={Russian},\r\nabbrev_source_title={Mol. Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Primary structure and functional activity of the Bacillus subtilis gene ribC.\n \n \n \n \n\n\n \n Gusarov, I.; Kreneva, R.; Rybak, K.; Podchernyaev, D.; Iomantas, Y.; Kolibaba, L.; Polanuer, B.; Kozlov, Y.; and Perumov, D.\n\n\n \n\n\n\n Molecular Biology, 31(5): 698-703. 1997.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Primary$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Gusarov1997698,\r\nauthor={Gusarov, I.I. and Kreneva, R.A. and Rybak, K.V. and Podchernyaev, D.A. and Iomantas, Yu.V. and Kolibaba, L.G. and Polanuer, B.M. and Kozlov, Yu.I. and Perumov, D.A.},\r\ntitle={Primary structure and functional activity of the Bacillus subtilis gene ribC},\r\njournal={Molecular Biology},\r\nyear={1997},\r\nvolume={31},\r\nnumber={5},\r\npages={698-703},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031323176&partnerID=40&md5=026b2eacb090b59eaebb3cf9bc5d6138},\r\naffiliation={Inst. Genet. Sel. Indust. M., Russian Academy of Sciences, Moscow, 113545, Russian Federation; Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, 188350, Russian Federation},\r\nabstract={The ribC gene controlling the riboflavin operon in Bacillus subtilis was cloned by the resistance to a riboflavin analog 7,8-dimethyl-10-(O-methylcetoxime)-isoalloxazine. The homology was revealed with the riboflavin kinase/FAD synthase gene from Corynebacrerium ammoniagenes and Escherichia coli. Riboflavin kinase/FAD synthase activity was detected in cell-free extracts, thus demonstrating that the ribC gene codes for a bifunctional enzyme producing FAD from riboflavin via FMN.},\r\nauthor_keywords={Bacillus subtilis;  Primary structure;  Regulatory gene;  Riboflavin operon},\r\ncorrespondence_address1={Gusarov, I.I.; Inst. Genet. Sel. Indust. M., Russian Academy of Sciences, Moscow, 113545, Russian Federation},\r\nissn={00268933},\r\nlanguage={English},\r\nabbrev_source_title={Mol. Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Phenotypic Expression of a 110-Nucleotide-Pair Deletion in the Regulatory Region of the Bacillus subtilis Riboflavin Operon.\n \n \n \n \n\n\n \n Kreneva, R.; Gusarov, I.; Kozlov, Y.; and Perumov, D.\n\n\n \n\n\n\n Russian Journal of Genetics, 33(5): 494-497. 1997.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Phenotypic$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva1997494,\r\nauthor={Kreneva, R.A. and Gusarov, I.I. and Kozlov, Yu.I. and Perumov, D.A.},\r\ntitle={Phenotypic Expression of a 110-Nucleotide-Pair Deletion in the Regulatory Region of the Bacillus subtilis Riboflavin Operon},\r\njournal={Russian Journal of Genetics},\r\nyear={1997},\r\nvolume={33},\r\nnumber={5},\r\npages={494-497},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-1842764840&partnerID=40&md5=a9fa2edffba03d9b8b1edfec35d3a519},\r\naffiliation={Konstantinov Inst. of Nucl. Physics, Russ. Academy of Sciences, Leningradskaya oblast, 188350, Russian Federation; State Res. Inst. Genet. Sel. I., Moscow, 113545, Russian Federation},\r\nabstract={Assessment of specific activity of riboflavin synthase and the level of riboflavin accumulation in strains with a 110-nucleotide deletion in the regulatory region of the riboflavin operon showed that this deletion specified semi-constitutive expression of the operon. This was assumed to be connected with the elimination of three nucleotides from a potential transcription antiterminator.},\r\ncorrespondence_address1={Kreneva, R.A.; Konstantinov Inst. of Nucl. Physics, Russ. Academy of Sciences, Leningradskaya oblast, 188350, Russian Federation},\r\nissn={10227954},\r\nlanguage={English},\r\nabbrev_source_title={Russ. J. Gen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n The genes for riboflavin biosynthesis in Bacillus amyloliquefaciens: Primary structure, organization, and regulation.\n \n \n \n \n\n\n \n Gusarov, I.; Kreneva, R.; Podchernyaev, D.; Iomantas, Y.; Abalakina, E.; Stoinova, N.; Perumov, D.; and Kozlov, Y.\n\n\n \n\n\n\n Molecular Biology, 31(3): 370-376. 1997.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Gusarov1997370,\r\nauthor={Gusarov, I.I. and Kreneva, R.A. and Podchernyaev, D.A. and Iomantas, Yu.V. and Abalakina, E.G. and Stoinova, N.V. and Perumov, D.A. and Kozlov, Yu.I.},\r\ntitle={The genes for riboflavin biosynthesis in Bacillus amyloliquefaciens: Primary structure, organization, and regulation},\r\njournal={Molecular Biology},\r\nyear={1997},\r\nvolume={31},\r\nnumber={3},\r\npages={370-376},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031516226&partnerID=40&md5=5caecdb4e3ae4f97d57838a97e55d803},\r\naffiliation={Inst. Genet. Sel. Indust. M., Russian Academy of Sciences, Moscow, 113545, Russian Federation; Institute of Nuclear Physics, Russian Academy of Sciences, Gatchina, 188350, Russian Federation},\r\nabstract={The nucleotide sequence of a 4286-nt fragment of Bacillus amyloliquefaciens chromosome was analyzed. The five structural genes for riboflavin biosynthesis were shown to form a linkage group similar in structure to the riboflavin operon of B. subtilis. Cross-regulation of riboflavin biosynthesis in B. subtilis and B. amyloliquefaciens allows a common mechanism of transcription regulation to be assumed.},\r\nauthor_keywords={Bacillus amyloliquefaciens;  Mechanism of transcription regulation;  Riboflavin biosynthesis;  Structural genes},\r\ncorrespondence_address1={Gusarov, I.I.; Inst. Genet. Sel. Indust. M., Russian Academy of Sciences, Moscow, 113545, Russian Federation},\r\nissn={00268933},\r\nlanguage={English},\r\nabbrev_source_title={Mol. Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties.\n \n \n \n \n\n\n \n \n\n\n \n\n\n\n Biochimie, 79(6): 373-384. 1997.\n cited By 58\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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\n \n 1996\n \n \n (7)\n \n \n

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\n \n\n \n \n \n \n \n \n Specific characteristics and primary structure of protein BASP1 initially found in axon terminals of neurons.\n \n \n \n \n\n\n \n Mosevitsky, M.; Caponi, J.; Skladchikova, G.; Novitskaya, V.; and Plekhanov, A.\n\n\n \n\n\n\n Biochemistry (Moscow), 61(7): 864-871. 1996.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Specific$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mosevitsky1996864,\r\nauthor={Mosevitsky, M.I. and Caponi, J.-P. and Skladchikova, G.Yu. and Novitskaya, V.A. and Plekhanov, A.Yu.},\r\ntitle={Specific characteristics and primary structure of protein BASP1 initially found in axon terminals of neurons},\r\njournal={Biochemistry (Moscow)},\r\nyear={1996},\r\nvolume={61},\r\nnumber={7},\r\npages={864-871},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0041682345&partnerID=40&md5=27246b1253aa65e130ec960c0d03e6f7},\r\naffiliation={Department of Molecular Biophysics, St. Petersburg Inst. of Nucl. Phys., Russian Academy of Sciences, Gatchina, Leningrad Region 188350, Russian Federation; Ctr. Rech. Biochim. Macromoleculaire, Route de Mende 1919, 34033 Montpellier, France},\r\nabstract={Brain acid-soluble protein 1 (BASP1) which prevails in growth cones and presynaptic regions of neurons was isolated with a group of acidic (pI 4.3-4.6) acid-soluble brain proteins. The group also includes the well-studied GAP-43/B-50 neuronal protein. However, the primary structure of BASP1 and GAP-43/B-50 appear to be different. BASP1 is hydrophobic due to the presence of an N-terminal myristic acid residue. BASP1 from various species contain extended regions of homology, but they induced species-specific polyclonal antibodies. Thus, the antigenic determinants in the BASP1 molecules from different species are located mostly outside the homologous regions. Besides brain, BASP1 was found in other tissues: lymphoid (thymus, spleen), kidney, and testis. The BASP1 from various tissues had identical physicochemical characteristics (presence of the myristic acid residue, pI, isoforms), suggesting that its function is similar in different tissues.},\r\nauthor_keywords={Brain proteins;  Posttranslational modification of proteins;  Protein primary structure},\r\ncorrespondence_address1={Mosevitsky, M.I.; Department of Molecular Biophysics, St. Petersburg Inst. of Nucl. Phys., Russian Academy of Sciences, Gatchina, Leningrad Region 188350, Russian Federation; email: mosev@lnpi.spb.su},\r\nissn={00062979},\r\ncoden={BIORA},\r\nlanguage={English},\r\nabbrev_source_title={Biochemistry Moscow},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Structural investigation of the organic anion transport system of the rat kidney brush border membrane by the affinity probe method.\n \n \n \n \n\n\n \n Orlov, Y.; and Kazbekov, E.\n\n\n \n\n\n\n Biologicheskie Membrany, 13(4): 395. 1996.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Structural$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Orlov1996395,\r\nauthor={Orlov, Yu.N. and Kazbekov, E.N.},\r\ntitle={Structural investigation of the organic anion transport system of the rat kidney brush border membrane by the affinity probe method},\r\njournal={Biologicheskie Membrany},\r\nyear={1996},\r\nvolume={13},\r\nnumber={4},\r\npages={395},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0039015420&partnerID=40&md5=8838adf84d420cfc1c708277d431edeb},\r\nabstract={A new method for investigation of the structural organization of the kidney organic anion transport system is suggested, based on the affinity labeling under conditions of the transport activation. Organic anion transporters in the rat kidney bursh border membrane (BBM) were identified using two affinity probes with different reactivity and under two different transport conditions. Bromoacetylated p-amino [3H]hippurate was shown to bind covalently under equilibrium exchange conditions to the BBM membrane proteins with molecular masses of 28, 63, 98 and 150 kDa. The data obtained with SITS and probenecid using as organic anion transport inhibitors indicate that the BBM proteins of 28, 63, and 98 kDa may correspond to the organic anion transport system. The transporters were identified under the initial uptake conditions using diazo[3H]hippurate in two versions: by the transport activation with chloride anions and without activation. Diazo[3H]hippurate was shown to bind covalently in the presence of chloride to the BBM proteins with molecular masses of 98 kDa and 28 KDa, whereas in the absence of chloride diazohippurate does not bind to anyone protein of this membrane.},\r\nissn={02334755},\r\nlanguage={Russian},\r\nabbrev_source_title={Biol. Membr.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Structural investigation of the organic anion transport system of the rat kidney brush border membrane by the affinity probe method.\n \n \n \n \n\n\n \n Orlov, Y.; and Kazbekov, E.\n\n\n \n\n\n\n Membrane and Cell Biology, 10(4): 421-428. 1996.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Structural$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Orlov1996421,\r\nauthor={Orlov, Yu.N. and Kazbekov, E.N.},\r\ntitle={Structural investigation of the organic anion transport system of the rat kidney brush border membrane by the affinity probe method},\r\njournal={Membrane and Cell Biology},\r\nyear={1996},\r\nvolume={10},\r\nnumber={4},\r\npages={421-428},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030455506&partnerID=40&md5=56c874bffacb4936356f43c6d8ed2339},\r\naffiliation={St. Petersburg Inst. Nuclear Physics, Russian Academy of Sciences, St. Petersburg, Russian Federation},\r\ncorrespondence_address1={Orlov, Yu.N.; St. Petersburg Inst. Nuclear Physics, Russian Academy of Sciences, St. Petersburg, Russian Federation},\r\nissn={10236597},\r\ncoden={MCBIE},\r\nlanguage={English},\r\nabbrev_source_title={MEMBR. CELL BIOL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Genetic Mapping of an Additional Regulatory Locus of the Bacillus subtilis Riboflavin Operon.\n \n \n \n \n\n\n \n Kreneva, R.; and Perumov, D.\n\n\n \n\n\n\n Russian Journal of Genetics, 32(12): 1412-1416. 1996.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Genetic$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva19961412,\r\nauthor={Kreneva, R.A. and Perumov, D.A.},\r\ntitle={Genetic Mapping of an Additional Regulatory Locus of the Bacillus subtilis Riboflavin Operon},\r\njournal={Russian Journal of Genetics},\r\nyear={1996},\r\nvolume={32},\r\nnumber={12},\r\npages={1412-1416},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542608009&partnerID=40&md5=292e84fe38684132d187f5e8b5d96aeb},\r\naffiliation={Dept. of Molec. and Radiat. Biophys., Konstantinov Inst. of Nucl. Physics, Russian Academy of Sciences, Gatchina Leningradskoi oblasti, St. Petersburg, 188350, Russian Federation},\r\nabstract={Two mutations designated ribR5 and ribR6, which effectively decrease the constitutive expression of the Bacillus subtilis riboflavin operon, were mapped in the 236° region of the B. subtilis genetic map based on linkage analysis with respect to the apt6 marker. Cotransfer indices for the ribR6 and ribR6 markers and apt6 suggest that both ribR mutations are alleles of exactly the same genetic locus. Total results of transductional and transformational crosses indicate the following marker order: pheA-apt6-ribR-azlB-aroD4. Phenotypic peculiarities of the ribR mutants allow us to assume that they belong to an additional subunit of the regulatory protein of the riboflavin operon.},\r\ncorrespondence_address1={Kreneva, R.A.; Dept. of Molec. and Radiat. Biophys., Konstantinov Inst. of Nucl. Physics, Russian Academy of Sciences, Gatchina Leningradskoi oblasti, St. Petersburg, 188350, Russian Federation},\r\nissn={10227954},\r\nlanguage={English},\r\nabbrev_source_title={Russ. J. Gen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Genetic mapping of an additional regulatory locus of the bacillus subtilis riboflavin operon.\n \n \n \n \n\n\n \n Kreneva, R.; and Perumov, D.\n\n\n \n\n\n\n Genetika, 32(12): 1623-1628. 1996.\n cited By 6\n\n\n\n
\n\n\n\n \n \n $\"Genetic$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva19961623,\r\nauthor={Kreneva, R.A. and Perumov, D.A.},\r\ntitle={Genetic mapping of an additional regulatory locus of the bacillus subtilis riboflavin operon},\r\njournal={Genetika},\r\nyear={1996},\r\nvolume={32},\r\nnumber={12},\r\npages={1623-1628},\r\nnote={cited By 6},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030334494&partnerID=40&md5=9b0eeb19bdc09eb2b8b6078aeb4adc8e},\r\naffiliation={Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, St. Petersburg, 188350, Russian Federation},\r\nabstract={Two mutations designated ribR5 and ribR6, which effectively decrease the constitutive expression of the Bacillus subtilis riboflavin operon, were mapped in the 236° region of the B. subtilis genetic map based on linkage analysis with respect to the apto marker. Cotransfer indices for the ribR5 and ribR6 markers and apto suggest that both ribR mutations are alleles of exactly the same genetic locus. Total results of transductional and transformational crosses indicate the following marker order: pheA-apt6-ribR-azlB-aroD4. Phenotypic peculiarities of the ribR mutants allow us to assume that they belong to an additional subunit of the regulatory protein of the riboflavin operon.},\r\ncorrespondence_address1={Kreneva, R.A.; Konstantinov Institute of Nuclear Physics, Russian Academy of Sciences, St. Petersburg, 188350, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={9102355},\r\nlanguage={Russian},\r\nabbrev_source_title={Genetika},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Immunoreplica from the gel surface: Rapid and sensitive blot plus intact gel.\n \n \n \n \n\n\n \n Plekhanov, A.\n\n\n \n\n\n\n Analytical Biochemistry, 239(1): 110-111. 1996.\n cited By 11\n\n\n\n
\n\n\n\n \n \n $\"Immunoreplica$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Plekhanov1996110,\r\nauthor={Plekhanov, A.Y.},\r\ntitle={Immunoreplica from the gel surface: Rapid and sensitive blot plus intact gel},\r\njournal={Analytical Biochemistry},\r\nyear={1996},\r\nvolume={239},\r\nnumber={1},\r\npages={110-111},\r\ndoi={10.1006/abio.1996.0298},\r\nnote={cited By 11},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030586298&doi=10.1006%2fabio.1996.0298&partnerID=40&md5=8625ce35294eab74c53ae1d28829a4c9},\r\naffiliation={Molecular and Radiation Biophysics Division, Petersburg Nuclear Physics Institute, Gatchina, Leningradskaja oblast, 188350, Russian Federation},\r\ncorrespondence_address1={Plekhanov, A.Y.; Molecular/Radiation Biophysics Div., Petersburg Nuclear Physics Institute, Leningradskaja oblast 188350, Russian Federation},\r\npublisher={Academic Press Inc.},\r\nissn={00032697},\r\ncoden={ANBCA},\r\npubmed_id={8660633},\r\nlanguage={English},\r\nabbrev_source_title={ANAL. BIOCHEM.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Specific characteristics and primary structure of BASP1 protein detected in axon terminals of neurons.\n \n \n \n \n\n\n \n Mosevitskij, M.; Kaponi, Z.; Skladchikova, G.; Novitskaya, V.; and Plekhanov, A.\n\n\n \n\n\n\n Biokhimiya, 61(7): 1209-1220. 1996.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Specific$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Mosevitskij19961209,\r\nauthor={Mosevitskij, M.I. and Kaponi, Zh.-P. and Skladchikova, G.Yu. and Novitskaya, V.A. and Plekhanov, A.Yu.},\r\ntitle={Specific characteristics and primary structure of BASP1 protein detected in axon terminals of neurons},\r\njournal={Biokhimiya},\r\nyear={1996},\r\nvolume={61},\r\nnumber={7},\r\npages={1209-1220},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030178677&partnerID=40&md5=ea5c188cdbd620a849128e5cddae7feb},\r\naffiliation={Sankt-Peterburgskij Inst Yadernoj, Fiziki RAN, Sankt-Peterburg, Russian Federation},\r\nabstract={The BASP1 protein is one of the acidic (pI 4.3-4.6) acid-soluble brain proteins; it is predominant in growth cones and presynaptic regions of neurons. This group also includes GAP-43/B-50 neuronal protein. However, primary structures of BASP1 and GAP-43/B-50 are different. Hydrophobicity of BASP1 protein is due to N-terminal myristic acid residue. BASP1 molecules purified from various animal species possess significant regions of homology; however, polyclonal antibodies raised against BASP1 from various species were species-specific. Hence, BASP1 molecules of various animal species include specific antigenic determinants located outside of the homology regions. Apart from brain, BASP1 was detected in several other tissues including lymphoid organs (spleen, thymus), kidney, and testis. Physico-chemical characteristics of brain BASP1 (myristoylation, pI, and isoforms) were identical with the proteins from other tissues. This suggests that BASP1 can have similar functions in various tissues.},\r\ncorrespondence_address1={Mosevitskij, M.I.; Sankt-Peterburgskij Inst Yadernoj, Fiziki RAN, Sankt-Peterburg, Russian Federation},\r\npublisher={East View Publ Inc, Minneapolis, MN, United States},\r\nissn={03209725},\r\ncoden={BIOHA},\r\npubmed_id={9035734},\r\nlanguage={Russian},\r\nabbrev_source_title={Biokhimiya},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1995\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Biological activity of poly(G)·poly(C) complex modified by bivalent platinum compounds.\n \n \n \n \n\n\n \n Aksenov, O.; Murina, E.; Kogan, E.; Platonova, G.; Sidorova, N.; and Timkovsky, A.\n\n\n \n\n\n\n Voprosy Virusologii, 40(2): 56-59. 1995.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Biological$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Aksenov199556,\r\nauthor={Aksenov, O.A. and Murina, E.A. and Kogan, E.M. and Platonova, G.A. and Sidorova, N.S. and Timkovsky, A.L.},\r\ntitle={Biological activity of poly(G)·poly(C) complex modified by bivalent platinum compounds},\r\njournal={Voprosy Virusologii},\r\nyear={1995},\r\nvolume={40},\r\nnumber={2},\r\npages={56-59},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028989542&partnerID=40&md5=54dcf51e628f6119e2f2ac29bfd04384},\r\naffiliation={NI Institut Detskikh Infektsij, Ross. Akademiya Meditsinskikh Nauk, Sankt-Peterburg, Russian Federation},\r\nabstract={Modification of poly(G)·poly(C) with cis-diaminodichloroplatinum (cis-DDP) at the level of r(b) = 0.02 increased the in vivo antiviral and interferon-inducing activity of the complex, in contrast to the data reported for complex poly(G)·poly(C). Antiinfluenza activity in this case depends on the meted of modification and increases more intensively when a ready complex is treated with cis-DDP, as against treatment of poly(G) alone before the formation of a complex with poly(C). If r(b) is increased, the activity reduces again. Modification with trans-DDP at r(b) = 0.02 also leads to an increase of antiinfluenza activity of poly(G)·poly(C), but mainly after pretreatment of poly(G).},\r\ncorrespondence_address1={Aksenov, O.A.; NI Institut Detskikh Infektsij, Ross. Akademiya Meditsinskikh Nauk, Sankt-Peterburg, Russian Federation},\r\nissn={05074088},\r\ncoden={VVIRA},\r\npubmed_id={7762230},\r\nlanguage={Russian},\r\nabbrev_source_title={VOPR. VIRUSOL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1994\n \n \n (2)\n \n \n

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\n \n \n

\n \n\n \n \n \n \n \n \n Affinity identification of organic anion transporters in brush-border membrane vesicles from rat kidney.\n \n \n \n \n\n\n \n Orlov, Y.; Zherebtsova, M.; and Kazbekov, E.\n\n\n \n\n\n\n BBA - Biomembranes, 1192(1): 117-124. 1994.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"Affinity$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Orlov1994117,\r\nauthor={Orlov, Yu.N. and Zherebtsova, M.A. and Kazbekov, E.N.},\r\ntitle={Affinity identification of organic anion transporters in brush-border membrane vesicles from rat kidney},\r\njournal={BBA - Biomembranes},\r\nyear={1994},\r\nvolume={1192},\r\nnumber={1},\r\npages={117-124},\r\ndoi={10.1016/0005-2736(94)90151-1},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028285386&doi=10.1016%2f0005-2736%2894%2990151-1&partnerID=40&md5=6e09987d305f1460a92473de5bf7db26},\r\naffiliation={St. Petersburg Institute of Nuclear Physics, the Academy of Sciences, 188350 Gatchina, Russian Federation},\r\nabstract={The inhibitory properties of bromoacetyl-p-aminohippuric acid as the affinity probe of the organic anion transport system were studied. Bromoacetylated p-aminohippurate was shown to be able to inhibit irreversibly the p-aminohippurate (PAH) uptake in brush-border membrane vesicles. The inhibition depends on both the time of treatment and the affinity probe concentration. The treatment of brush-border membrane with 1 mM bromoacetyl-p-aminohippurate for 1.5 h results in 100% irreversible inhibition of PAH transport but no changes were observed in the activity of alkaline phosphatase, γ-glutamyltranspeptidase or maltase. The affinity labelling of the organic anion transporters was performed with bromoacetyl-p-amino[3H]hippuric acid. It was shown, by means of SDS-polyacrylamide gel electrophoresis, that the probe bound covalently to the brush-border membrane proteins with molecular masses of 28 kDa, 63 kDa, 98 kDa, and &gt; 150 kDa. The data obtained with SITS and probenecide as the organic anion transport inhibitors indicate that brush-border membrane proteins of 28 kDa, 63 kDa, 98 kDa may correspond to the organic anion transport system. © 1994.},\r\nauthor_keywords={(Rat kidney);  Anion uptake;  Membrane;  Transport protein;  Vesicle transport},\r\ncorrespondence_address1={Orlov, Yu.N.; St. Petersburg Institute of Nuclear Physics, the Academy of Sciences, 188350 Gatchina, Russian Federation},\r\nissn={00052736},\r\ncoden={BBBMB},\r\npubmed_id={8204641},\r\nlanguage={English},\r\nabbrev_source_title={Biochim. Biophys. Acta Biomembr.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Neuronal protein GAP-43 is a member of novel group of brain acid-soluble proteins (BASPs).\n \n \n \n \n\n\n \n Mosevitsky, M.; Novitskaya, V.; Plekhanov, A.; and Skladchikova, G.\n\n\n \n\n\n\n Neuroscience Research, 19(2): 223-228. 1994.\n cited By 25\n\n\n\n
\n\n\n\n \n \n $\"Neuronal$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Mosevitsky1994223,\r\nauthor={Mosevitsky, M.I. and Novitskaya, V.A. and Plekhanov, A.Yu. and Skladchikova, G.Yu.},\r\ntitle={Neuronal protein GAP-43 is a member of novel group of brain acid-soluble proteins (BASPs)},\r\njournal={Neuroscience Research},\r\nyear={1994},\r\nvolume={19},\r\nnumber={2},\r\npages={223-228},\r\ndoi={10.1016/0168-0102(94)90146-5},\r\nnote={cited By 25},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028230581&doi=10.1016%2f0168-0102%2894%2990146-5&partnerID=40&md5=153579e6a1178a2b601e53f15fa82012},\r\naffiliation={Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Gatchina, Leningrad District Leningrad,, Russian Federation},\r\nabstract={A group of brain acid-soluble proteins (BASPs) is preliminarily characterized. In some respects BASPs are similar to high mobility group (HMG) proteins, but in contrast to HMG, all BASPs are very acidic (pI 4.4-4.6) and show abnormal mobility during SDS-PAGE electrophoresis. BASP1-2 and BASP2-2 are identified as the two forms of neuronal protein GAP-43 (B-50, pp46, F1, neuromodulin). BASP1 and BASP3 are apparently novel brain proteins. © 1994.},\r\nauthor_keywords={B-50;  Brain acid-soluble proteins;  Brain-specific proteins;  GAP-43;  HMG},\r\ncorrespondence_address1={Mosevitsky, M.I.; Division of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Gatchina, Leningrad District Leningrad,, Russian Federation; email: kazbekov@lnpi.spb.su},\r\nissn={01680102},\r\ncoden={NERAD},\r\npubmed_id={8008250},\r\nlanguage={English},\r\nabbrev_source_title={Neurosci. Res.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1992\n \n \n (3)\n \n \n

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\n \n\n \n \n \n \n \n \n Riboflavin operon of Bacillus subtilis: unusual symmetric arrangement of the regulatory region.\n \n \n \n \n\n\n \n Kil, Y.; Mironovi, V.; Gorishin, I.; Kreneva, R.; and Perumov, D.\n\n\n \n\n\n\n MGG Molecular & General Genetics, 233(3): 483-486. 1992.\n cited By 55\n\n\n\n
\n\n\n\n \n \n $\"Riboflavin$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kil1992483,\r\nauthor={Kil, Y.V. and Mironovi, V.N. and Gorishin, I.Yu. and Kreneva, R.A. and Perumov, D.A.},\r\ntitle={Riboflavin operon of Bacillus subtilis: unusual symmetric arrangement of the regulatory region},\r\njournal={MGG Molecular & General Genetics},\r\nyear={1992},\r\nvolume={233},\r\nnumber={3},\r\npages={483-486},\r\ndoi={10.1007/BF00265448},\r\nnote={cited By 55},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026632334&doi=10.1007%2fBF00265448&partnerID=40&md5=229405cbf898604bba7b431fec915367},\r\naffiliation={Department of Molecular and Radiation Biophysics, Leningrad Nuclear Physics Institute of the Academy of Sciences of the USSR, Gatchina, Leningrad District, 188350, Russia; Centre of Bioengineering, Institute of Molecular Biology of the Academy of Sciences of the USSR, Moscow, 117984, Russia},\r\nabstract={Seventeen cis-dominant mutations leading to riboflavin overproduction in Bacillus subtilis were localized to the region between nucleotides + 37 and + 159 relative to the transcription initiation site of the riboflavin operon. This region displays an unusual structure for regulatory sequences. The main part of it represents clusters of A/T and G/Grich sequences that symmetrically blank a short inverted repeat. © 1992 Springer-Verlag.},\r\nauthor_keywords={Bacillus subtilis;  Regulatory mutants;  Riboflavin operon},\r\ncorrespondence_address1={Perumov, D.A.; Department of Molecular and Radiation Biophysics, Leningrad Nuclear Physics Institute of the Academy of Sciences of the USSR, Gatchina, Leningrad District, 188350, Russia},\r\npublisher={Springer-Verlag},\r\nissn={00268925},\r\ncoden={MGGEA},\r\npubmed_id={1620102},\r\nlanguage={English},\r\nabbrev_source_title={Molec. Gen. Genet.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Induction of the SOS-like system in Rec-mutants of Bacillus subtilis [Induktsiia SOS-podobnoǐ sistemy u Rec-mutantov Bacillus subtilis.].\n \n \n \n \n\n\n \n Suslov, A.; Suslova, I.; Kreneva, R.; and Kalinin, V.\n\n\n \n\n\n\n Molekuliarnaia genetika, mikrobiologiia i virusologiia, (5-6): 16-19. 1992.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Induction$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Suslov199216,\r\nauthor={Suslov, A.V. and Suslova, I.N. and Kreneva, R.A. and Kalinin, V.L.},\r\ntitle={Induction of the SOS-like system in Rec-mutants of Bacillus subtilis [Induktsiia SOS-podobnoǐ sistemy u Rec-mutantov Bacillus subtilis.]},\r\njournal={Molekuliarnaia genetika, mikrobiologiia i virusologiia},\r\nyear={1992},\r\nnumber={5-6},\r\npages={16-19},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026863295&partnerID=40&md5=5f42afb6505148edda7ee334b57d1bae},\r\nabstract={Influence of the recE1, recB2, recB3, recB19, recF15, recF18, recL16, recM13 and recM27 mutations of the induction of the SOS-like system component, i. e. the RecE protein of Bacillus subtilis was studied by RIA-dot-blot method in UV-irradiated or treated by nalidixic acid cells. These agents caused a significant increase in the wild type (rec+) cells but did not stimulate the RecE synthesis in the rec mutants tested. The two exceptions were recB2 and recF18 mutants treated by nalidixic acid. The tsi23 mutation caused thermoinduction of phi 105 bacteriophage in the rec+ genetic background while no prophage particles were induced in the recE, recF, recL, recM mutants. The data suggest that the genetic damage of several rec genes including recB, recE, recF, recL and recM can block induction of the SOS-like system of Bacillus subtilis.},\r\ncorrespondence_address1={Suslov, A.V.},\r\nissn={02080613},\r\npubmed_id={1454077},\r\nlanguage={Russian},\r\nabbrev_source_title={Mol Gen Mikrobiol Virusol},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Resistance of natural and synthetic polyribonucleotide inductors of interferon to human blood ribonucleases.\n \n \n \n \n\n\n \n Surzhik, M.; Dyatlova, N.; Glazunov, E.; Timkovsky, A.; Vlasov, G.; and Kozhevnikova Yu., N.\n\n\n \n\n\n\n Antibiotiki i Khimioterapiya, 37(1): 21-23. 1992.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Resistance$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Surzhik199221,\r\nauthor={Surzhik, M.A. and Dyatlova, N.G. and Glazunov, E.A. and Timkovsky, A.L. and Vlasov, G.P. and Kozhevnikova Yu., N.},\r\ntitle={Resistance of natural and synthetic polyribonucleotide inductors of interferon to human blood ribonucleases},\r\njournal={Antibiotiki i Khimioterapiya},\r\nyear={1992},\r\nvolume={37},\r\nnumber={1},\r\npages={21-23},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026609858&partnerID=40&md5=dcbb9c42f9c485c009156613babb8656},\r\naffiliation={Institute of Nuclear Physics, USSR Academy of Sciences, St. Petersburg, Russia},\r\ncorrespondence_address1={Surzhik, M.A.; Institute of Nuclear Physics, USSR Academy of Sciences, St. Petersburg, Russia},\r\nissn={02352990},\r\ncoden={ANKHE},\r\npubmed_id={1530353},\r\nlanguage={Russian},\r\nabbrev_source_title={ANTIBIOT. KHIMIOTER.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1990\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Genetic mapping of regulatory mutations of Bacillus subtilis riboflavin operon.\n \n \n \n \n\n\n \n Kreneva, R.; and Perumov, D.\n\n\n \n\n\n\n MGG Molecular & General Genetics, 222(2-3): 467-469. 1990.\n cited By 37\n\n\n\n
\n\n\n\n \n \n $\"Genetic$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva1990467,\r\nauthor={Kreneva, R.A. and Perumov, D.A.},\r\ntitle={Genetic mapping of regulatory mutations of Bacillus subtilis riboflavin operon},\r\njournal={MGG Molecular & General Genetics},\r\nyear={1990},\r\nvolume={222},\r\nnumber={2-3},\r\npages={467-469},\r\ndoi={10.1007/BF00633858},\r\nnote={cited By 37},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025365307&doi=10.1007%2fBF00633858&partnerID=40&md5=08d0f7df3fc8a7467e4531b0c3d9f1d5},\r\naffiliation={Department of Molecular and Radiation Biophysics, Leningrad Nuclear Physic Institute of the Academy of Sciences of the USSR, Gatchina, Leningrad District, 188350, Russia},\r\nabstract={Seven mutations leading to riboflavin overproduction in Bacillus subtilis were found to be linked to the marker dnaF133 (145° on the B. subtilis genetic map) by transformation. Cotransfer indexes (42.5%-61.7%) suggest that the ribC mutations are alleles of the same locus. Results of transduction and transformation crosses suggest the following order of markers:pyrD26 -ts-6 -dnaF133 -ribC -recA1. © 1990 Springer-Verlag.},\r\nauthor_keywords={Bacillus subtilis;  Riboflavin operon-Regulatory mutants},\r\ncorrespondence_address1={Kreneva, R.A.; Department of Molecular and Radiation Biophysics, Leningrad Nuclear Physic Institute of the Academy of Sciences of the USSR, Gatchina, Leningrad District, 188350, Russia},\r\npublisher={Springer-Verlag},\r\nissn={00268925},\r\ncoden={MGGEA},\r\npubmed_id={2125694},\r\nlanguage={English},\r\nabbrev_source_title={Mol Gen Genet},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1989\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n The influence of the lipid bilayer phase state on the p-aminohippurate (PAH) transport and the activity of the alkaline phosphatase in brush-border membrane vesicles from normal and mutant rats.\n \n \n \n \n\n\n \n Bresler, V.; Valter, S.; Jerebtsova, M.; Isayev-Ivanov, V.; Kazbekov, E.; Kleiner, A.; Orlov, Y.; Ostapenko, I.; Suchodolova, A.; and Fomichev, V.\n\n\n \n\n\n\n BBA - Biomembranes, 982(2): 288-294. 1989.\n cited By 6\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Bresler1989288,\r\nauthor={Bresler, V.M. and Valter, S.N. and Jerebtsova, M.A. and Isayev-Ivanov, V.V. and Kazbekov, E.N. and Kleiner, A.R. and Orlov, Yu.N. and Ostapenko, I.A. and Suchodolova, A.T. and Fomichev, V.N.},\r\ntitle={The influence of the lipid bilayer phase state on the p-aminohippurate (PAH) transport and the activity of the alkaline phosphatase in brush-border membrane vesicles from normal and mutant rats},\r\njournal={BBA - Biomembranes},\r\nyear={1989},\r\nvolume={982},\r\nnumber={2},\r\npages={288-294},\r\ndoi={10.1016/0005-2736(89)90066-7},\r\nnote={cited By 6},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024359970&doi=10.1016%2f0005-2736%2889%2990066-7&partnerID=40&md5=9b3d4c17f62c79b79def2b1f8e5ac170},\r\naffiliation={Leningrad Institute of Nuclear Physics, the Academy of Sciences, the U.S.S.R., Russian Federation},\r\nabstract={The kinetic parameters of p-aminohippurate transport and activity of the alkaline phosphatase were studied using brush-border membrane vesicles isolated from the kidney cortex of normal and mutant (strain of Campbell) rats. p-Aminohippurate (PAH) transport of both normal and mutant animals was carried out by the mechanism of facilitated diffusion. The apparent Michaelis constant at 36° C was equal to 7 mM, the maximal rate of PAH transport was 15 nmol/min per mg protein and the constant of inhibition by probenecide was 0.5 mM for normal rats and respectively, 29 mM, 62 nmol/min per mg protein and 1.4 mM for mutant rats. The Arrhenius plot for the PAH transport and activity of the alkaline phosphatase showed the breakpoints at 28-30°C for normal rats at 36-38°C for the Campbell strain rats. The thermotropic phase transitions detected by the EPR method with 5-doxylstearate as a probe were recorded at 21-30°C and 30-35°C for normal and mutant rats, respectively. Therefore, characteristic features of the PAH carrier and alkaline phosphatase activity in normal and Campbell strain rats are determined by the difference in the phase state of their membrane lipid bilayers. We suppose that mutation in the Campbell strain gives rise to a membrane pleotropic effect which enables us to understand the mechanism of genetic control of the lipid structure and membrane fluidity. © 1989.},\r\nauthor_keywords={(Rat);  Alkaline phosphatase;  Apical membrane;  Campbell mutation;  Lipid bilayer;  p-Aminohippurate carrier;  Phase state},\r\ncorrespondence_address1={Kazbekov, E.N.; Leningrad Institute of Nuclear Physics, the Academy of Sciences, the U.S.S.R.Russian Federation},\r\nissn={00052736},\r\ncoden={BBBMB},\r\npubmed_id={2752028},\r\nlanguage={English},\r\nabbrev_source_title={Biochim. Biophys. Acta Biomembr.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Tissue specificity of nucleo‐cytoplasmic distribution of HMG1 and HMG2 proteins and their probable functions.\n \n \n \n \n\n\n \n MOSEVITSKY, M.; NOVITSKAYA, V.; IOGANNSEN, M.; and ZABEZHINSKY, M.\n\n\n \n\n\n\n European Journal of Biochemistry, 185(2): 303-310. 1989.\n cited By 101\n\n\n\n
\n\n\n\n \n \n $\"Tissue$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{MOSEVITSKY1989303,\r\nauthor={MOSEVITSKY, M.I. and NOVITSKAYA, V.A. and IOGANNSEN, M.G. and ZABEZHINSKY, M.A.},\r\ntitle={Tissue specificity of nucleo‐cytoplasmic distribution of HMG1 and HMG2 proteins and their probable functions},\r\njournal={European Journal of Biochemistry},\r\nyear={1989},\r\nvolume={185},\r\nnumber={2},\r\npages={303-310},\r\ndoi={10.1111/j.1432-1033.1989.tb15116.x},\r\nnote={cited By 101},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024469223&doi=10.1111%2fj.1432-1033.1989.tb15116.x&partnerID=40&md5=88b2206528df7fa5d63b0641b2fddbd8},\r\naffiliation={Laboratory of Biopolymers, Leningrad Nuclear Physics Institute, USSR Academy of Sciences},\r\nabstract={The levels and distribution between nucleus and cytoplasm of HMG1 and HMG2 proteins have been investigated in different tissues of mammals. In lymphoid tissues and testis high amounts of these proteins are present in both nuclei and cytoplasm, while in the hepatic tissues and brain they accumulate in cytoplasm, mainly in the cytosol. In particular, very low amounts, if any, of HMG1 and 2 are present in the nuclei active for DNA replication (rat regenerating liver and primary hepatoma) or transcription (adult liver and brain). Therefore, it appears that HMG1 and 2 are not necessary for these processes. On the other hand, nuclear (chromosomal) HMG1 and 2 are characteristic for the tissues containing undifferentiated cells: lymphoid tissues, testis, neonatal liver. These proteins are bound to the chromatin regions solubilized early by sonication or DNase action. Comparison of the data obtained for different tissues shows an inverse correlation between the amounts of chromosomal HMG1 and 2, on the one hand, and of histone H1°, on the other hand. These results suggest that chromosomal HMG1 and 2 take part in the processes that occur during cell differentiation, while histone H1° is induced to preserve differentiated cells from dedifferentiation. Copyright © 1989, Wiley Blackwell. All rights reserved},\r\ncorrespondence_address1={MOSEVITSKY, M.I.; Laboratory of Biopolymers, Leningrad Nuclear Physics Institute of Academy of Sciences of the USSR, Gatchina, Leningrad, 188350},\r\nissn={00142956},\r\npubmed_id={2583185},\r\nlanguage={English},\r\nabbrev_source_title={Eur. J. Biochem.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

\n

\n \n 1987\n \n \n (1)\n \n \n

\n

\n \n \n

\n \n\n \n \n \n \n \n \n Concentration Peculiarities of a Set of Impurity Centres in Fluorite Crystals Activated by Gadolinium.\n \n \n \n \n\n\n \n Orlov, Y.; Aleshin, V.; Arkhangelskii, G.; Bozhevolnov, V.; Voronov, Y.; Ivanov, L.; Karelin, V.; and Saunin, E.\n\n\n \n\n\n\n physica status solidi (b), 144(2): K77-K80. 1987.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"Concentration$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Orlov1987K77,\r\nauthor={Orlov, Yu.N. and Aleshin, V.I. and Arkhangelskii, G.E. and Bozhevolnov, V.E. and Voronov, Yu.V. and Ivanov, L.N. and Karelin, V.V. and Saunin, E.I.},\r\ntitle={Concentration Peculiarities of a Set of Impurity Centres in Fluorite Crystals Activated by Gadolinium},\r\njournal={physica status solidi (b)},\r\nyear={1987},\r\nvolume={144},\r\nnumber={2},\r\npages={K77-K80},\r\ndoi={10.1002/pssb.2221440252},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-84983845381&doi=10.1002%2fpssb.2221440252&partnerID=40&md5=64f5e4c76ea1db6d5cdb32a5b81bffed},\r\naffiliation={Chemistry Department, Moscow State University, Academy of Sciences of the USSR, Moscow; P.N. Lebedev Physical Institute, Academy of Sciences of the USSR, Moscow; Institute of Physical Chemistry, Academy of Sciences of the Ussr, Moscow},\r\ncorrespondence_address1={Orlov, Yu.N.; Chemistry Department, Moscow State University, Academy of Sciences of the USSR, Moscow},\r\nissn={03701972},\r\nlanguage={English},\r\nabbrev_source_title={Phys. Status Solidi B Basic Res.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n\n\n\n

\n

\n \n 1986\n \n \n (2)\n \n \n

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\n \n \n

\n \n\n \n \n \n \n \n \n Emulsion polymerization of styrene in the presence of copolymerizing emulsifiers: Dimethylaminoethyl methacrylate derivatives.\n \n \n \n \n\n\n \n Orlov, Y.; Yegorov, V.; Simakova, G.; Gritskova, I.; and Zubov, V.\n\n\n \n\n\n\n Polymer Science U.S.S.R., 28(2): 423-428. 1986.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Emulsion$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Orlov1986423,\r\nauthor={Orlov, Yu.N. and Yegorov, V.V. and Simakova, G.A. and Gritskova, I.A. and Zubov, V.P.},\r\ntitle={Emulsion polymerization of styrene in the presence of copolymerizing emulsifiers: Dimethylaminoethyl methacrylate derivatives},\r\njournal={Polymer Science U.S.S.R.},\r\nyear={1986},\r\nvolume={28},\r\nnumber={2},\r\npages={423-428},\r\ndoi={10.1016/0032-3950(86)90101-2},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023292493&doi=10.1016%2f0032-3950%2886%2990101-2&partnerID=40&md5=e8ae578a298212106f5b4632b40f64ab},\r\naffiliation={Lomonosov State University, Moscow, Russian Federation},\r\nabstract={The emulsion polymerization of styrene was investigated in presence of cation-active emulsifier monomers, namely N-alkyl-, N,N-dimethyl- and N-methacryloyloxyethylammonium bromides. It was found that the emulsifiers copolymerize with the main monomer. This makes it possible to obtain stable latices whose aqueous phase contains no emulsifier. In the studied system the length of the alipathic chain in the emulsifying monomer molecule determines the stability and the dispersity of the initial emulsion, as well as the polymerization kinetics and changes in the surface tension of the latex with the degree of conversion. However it does not influence the mechanism of styrene copolymerization with the emulsifying monomer. © 1987.},\r\ncorrespondence_address1={Orlov, Yu.N.; Lomonosov State University, Moscow, Russian Federation},\r\nissn={00323950},\r\nlanguage={English},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Emulsion polymerization of styrene in presence of allylammonium emulsifiers.\n \n \n \n \n\n\n \n Orlov, Y.; Yegorov, V.; Gritskova, I.; Zubov, V.; Kabanov, V.; and Pravednikov, A.\n\n\n \n\n\n\n Polymer Science U.S.S.R., 28(3): 549-554. 1986.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Emulsion$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Orlov1986549,\r\nauthor={Orlov, Yu.N. and Yegorov, V.V. and Gritskova, I.A. and Zubov, V.P. and Kabanov, V.A. and Pravednikov, A.N.},\r\ntitle={Emulsion polymerization of styrene in presence of allylammonium emulsifiers},\r\njournal={Polymer Science U.S.S.R.},\r\nyear={1986},\r\nvolume={28},\r\nnumber={3},\r\npages={549-554},\r\ndoi={10.1016/0032-3950(86)90179-6},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023016214&doi=10.1016%2f0032-3950%2886%2990179-6&partnerID=40&md5=c138f00af414541ac0391ab0a8adbb4e},\r\naffiliation={Lomonosov State University, Moscow, Russian Federation},\r\nabstract={The process of emulsion polymerization of styrene initiated by oil- and water-soluble initiators in presence of mono-, di- and tri-allylalkysmmonium bromides has been studied. The influence of the nature and concentration of the initiator and emulsifier on the kinetics of the process of emulsion polymerization of styrene has been demonstrated. © 1987.},\r\ncorrespondence_address1={Orlov, Yu.N.; Lomonosov State University, Moscow, Russian Federation},\r\nissn={00323950},\r\nlanguage={English},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1985\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n HMG proteins in cell nuclei with different activities for transcription and proliferation.\n \n \n \n \n\n\n \n Mosevitsky, M.; Novitskaya, V.; Iogannsen, M.; and Zabezhinsky, M.\n\n\n \n\n\n\n Molekulyarnaya Biologiya, 19(3): 722-729. 1985.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"HMG$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Mosevitsky1985722,\r\nauthor={Mosevitsky, M.I. and Novitskaya, V.A. and Iogannsen, M.G. and Zabezhinsky, M.A.},\r\ntitle={HMG proteins in cell nuclei with different activities for transcription and proliferation},\r\njournal={Molekulyarnaya Biologiya},\r\nyear={1985},\r\nvolume={19},\r\nnumber={3},\r\npages={722-729},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021847346&partnerID=40&md5=95ea17189b9e46ef81931258f7b71550},\r\naffiliation={B.P. Konstantinov Institute of Nuclear Physics, Academy of Sciences of the USSR, Gatchina, Russian Federation},\r\nissn={00268984},\r\ncoden={MOBIB},\r\npubmed_id={3839898},\r\nlanguage={Russian},\r\nabbrev_source_title={MOL. BIOL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n COLLOID-CHEMICAL PROPERTIES OF CATIONIC SURFACTANT VINYL MONOMERS IN WATER.\n \n \n \n \n\n\n \n Batrakova, E.; Orlov, Y.; Egorov, V.; Zubov, V.; Titkova, L.; Shapiro, Y.; and Kabanov, V.\n\n\n \n\n\n\n Colloid journal of the USSR, 47(1): 104-107. 1985.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"COLLOID-CHEMICAL$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Batrakova1985104,\r\nauthor={Batrakova, E.V. and Orlov, Yu.N. and Egorov, V.V. and Zubov, V.P. and Titkova, L.V. and Shapiro, Yu.E. and Kabanov, V.A.},\r\ntitle={COLLOID-CHEMICAL PROPERTIES OF CATIONIC SURFACTANT VINYL MONOMERS IN WATER.},\r\njournal={Colloid journal of the USSR},\r\nyear={1985},\r\nvolume={47},\r\nnumber={1},\r\npages={104-107},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021897322&partnerID=40&md5=06f915ba650ddcf96e7fe18b2c304642},\r\naffiliation={Moscow Univ, Chemistry Dep, Moscow,, USSR, Moscow Univ, Chemistry Dep, Moscow, USSR},\r\nabstract={The ring detachment method, viscometry, and paramagnetic resonance have been applied to investigate aqueous dispersions of cationic surfactant monomers (SM), based on allylammonium and methacryloylethylammonium salts with different numbers and sizes of aliphatic chains. Transitions of spherical micelles to anisotropic micelles and further to lamellae have been observed in micellar solutions of single-chain and double-chain SM, accompanied by a reduced mobility of the molecules in the associate. Liposomelike structures have been detected in dispersions of two-chain SM prepared by ultrasound. In the case of diallylammonium salts the micelles, lamellae, and liposomes of SM have been fixed by radical polymerization.},\r\ncorrespondence_address1={Batrakova, E.V.; Moscow Univ, Chemistry Dep, Moscow,, USSR, Moscow Univ, Chemistry Dep, Moscow, USSR},\r\nissn={00101303},\r\ncoden={COJOA},\r\nlanguage={English},\r\nabbrev_source_title={Colloid J USSR},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1984\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n Puromycin binding to the donor (P-) site of Escherichia coli ribosomes.\n \n \n \n \n\n\n \n Ivanov, Y.; and Saminsky, E.\n\n\n \n\n\n\n BBA - General Subjects, 800(2): 203-206. 1984.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"Puromycin$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Ivanov1984203,\r\nauthor={Ivanov, Y.V. and Saminsky, E.M.},\r\ntitle={Puromycin binding to the donor (P-) site of Escherichia coli ribosomes},\r\njournal={BBA - General Subjects},\r\nyear={1984},\r\nvolume={800},\r\nnumber={2},\r\npages={203-206},\r\ndoi={10.1016/0304-4165(84)90061-8},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021133363&doi=10.1016%2f0304-4165%2884%2990061-8&partnerID=40&md5=e55538ed638ab40a488035269ee98f4c},\r\naffiliation={B.P. Konstantinov Nuclear Physics Institute, Academy of Sciences of the U.S.S.R., Gatchina, Leningrad district, 188350 U.S.S.R.},\r\nabstract={Puromycin inhibits the interaction of peptidyl-tRNA analogues AcPhe-tRNAox-redPhe, AcPhe-tRNAPhe and fMet-tRNAfMet with the donor (P-) site of Escherichia coli ribosomes. affects almost equally both the rate of the binding and the equilibrium of the system. This means that the effect is due to direct competition for the P-site, but not due to the indirect influence via the acceptor (A-) site. The inhibition was observed also in 30 S ribosomal subunits, therefore the puromycin binding site is situated far from the peptidyl transferase center. Quantitative measurements show that the affinity of puromycin for its new ribosomal binding site is similar to its affinity for the acceptor site of the peptidyl transferase center. © 1984.},\r\nauthor_keywords={(E. coli);  Puromycin;  Ribosomal P-site;  tRNA-ribosome interaction},\r\ncorrespondence_address1={Ivanov, Y.V.},\r\nissn={03044165},\r\ncoden={BBGSB},\r\nlanguage={English},\r\nabbrev_source_title={Biochim. Biophys. Acta Gen. Subj.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Puromycin interacts with the donor (P) site of Escherichia coli ribosomes.\n \n \n \n \n\n\n \n Ivanov, Y.; and Saminsky, E.\n\n\n \n\n\n\n Molekulyarnaya Biologiya, 18(5): 1301-1305. 1984.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Puromycin$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Ivanov19841301,\r\nauthor={Ivanov, Y.V. and Saminsky, E.M.},\r\ntitle={Puromycin interacts with the donor (P) site of Escherichia coli ribosomes},\r\njournal={Molekulyarnaya Biologiya},\r\nyear={1984},\r\nvolume={18},\r\nnumber={5},\r\npages={1301-1305},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021492785&partnerID=40&md5=f5d4ff6c6be9cb668bfb7ae473943eff},\r\naffiliation={B.P. Konstantinov Institute of Nuclear Physics, Academy of Sciences of the USSR, Gatchina, Leningrad Region},\r\nissn={00268984},\r\ncoden={MOBIB},\r\npubmed_id={6390175},\r\nlanguage={Russian},\r\nabbrev_source_title={MOL. BIOL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1983\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Electrochemistry of double-stranded complexes of synthetic polyribonucleotides having interferonogenic and antiviral activity.\n \n \n \n \n\n\n \n Brabec, V.; and Timkovsky, A.\n\n\n \n\n\n\n General Physiology and Biophysics, 2(6): 487-497. 1983.\n cited By 7\n\n\n\n
\n\n\n\n \n \n $\"Electrochemistry$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Brabec1983487,\r\nauthor={Brabec, V. and Timkovsky, A.L.},\r\ntitle={Electrochemistry of double-stranded complexes of synthetic polyribonucleotides having interferonogenic and antiviral activity.},\r\njournal={General Physiology and Biophysics},\r\nyear={1983},\r\nvolume={2},\r\nnumber={6},\r\npages={487-497},\r\nnote={cited By 7},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020951437&partnerID=40&md5=96767c7777022247995ba276e0712b8a},\r\nabstract={Double-stranded (ds) complexes of poly(C) with poly(G) and poly(G,I) were studied using differential pulse polarography (DPP) and differential pulse voltammetry at a pyrolytic graphite electrode (DPV). The complex formed by copolymer was found to be DPP inactive. On the other hand, poly(G).poly(C) yielded a small DPP peak corresponding to single-stranded (ss) poly(C). It was suggested that ss poly(C) present in the solutions of poly(G).poly(C) appeared due to the existence of segments in poly(G) during the complex-forming process in which guanine residues were unable to be hydrogen-bonded with bases in poly(C). Polynucleotide complexes investigated in this report yielded a DPV peak corresponding to electrooxidation of guanine residues, which was markedly lower than that yielded by ss polymers. Moreover, this DPV peak yielded by the complex prepared from an equimolar mixture of poly(G) and poly(C) was still markedly higher than that yielded by poly(G,I).poly(C), or by poly(G).poly(C) prepared in the excess of poly(C). The lowering of the DPV peak was explained as being particularly due to the presence of the polynucleotide segments with an intact and regular secondary structure. The results of our electrochemical analysis of the complexes investigated were compared with their biological activity reported earlier. This comparison calls attention to the fact that biological effectiveness of these biopolymers may be dependent on details of their secondary structure which may be monitored using the methods of electrochemical analysis.},\r\ncorrespondence_address1={Brabec, V.},\r\nissn={02315882},\r\npubmed_id={6678777},\r\nlanguage={English},\r\nabbrev_source_title={Gen Physiol Biophys},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1982\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n Peculiarities of spontaneous plasmid transformation on a solid medium in Bacillus subtilis.\n \n \n \n \n\n\n \n Vinogradskaya, G.; and Mosevitsky, M.\n\n\n \n\n\n\n Genetika, 18(8): 1371-1373. 1982.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Peculiarities$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Vinogradskaya19821371,\r\nauthor={Vinogradskaya, G.R. and Mosevitsky, M.L.},\r\ntitle={Peculiarities of spontaneous plasmid transformation on a solid medium in Bacillus subtilis},\r\njournal={Genetika},\r\nyear={1982},\r\nvolume={18},\r\nnumber={8},\r\npages={1371-1373},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020335827&partnerID=40&md5=4a4dbadf30590b03fa27bc95b27c48f7},\r\naffiliation={B.P. Konstantinov Leningrad Inst. Nucl. Phys., Acad. Sci. USSR, Gatchina},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={6813194},\r\nlanguage={Russian},\r\nabbrev_source_title={GENETIKA},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n 70‐S Ribosomes of Escherichia coli Have an Additional Site for Deacylated tRNA Binding.\n \n \n \n \n\n\n \n GRAJEVSKAJA, R.; IVANOV, Y.; and SAMINSKY, E.\n\n\n \n\n\n\n European Journal of Biochemistry, 128(1): 47-52. 1982.\n cited By 82\n\n\n\n
\n\n\n\n \n \n $\"70‐S$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{GRAJEVSKAJA198247,\r\nauthor={GRAJEVSKAJA, R.A. and IVANOV, Y.V. and SAMINSKY, E.M.},\r\ntitle={70‐S Ribosomes of Escherichia coli Have an Additional Site for Deacylated tRNA Binding},\r\njournal={European Journal of Biochemistry},\r\nyear={1982},\r\nvolume={128},\r\nnumber={1},\r\npages={47-52},\r\ndoi={10.1111/j.1432-1033.1982.tb06929.x},\r\nnote={cited By 82},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0020352845&doi=10.1111%2fj.1432-1033.1982.tb06929.x&partnerID=40&md5=ebdd8a0ab3ab89295198bbec78d9abcc},\r\naffiliation={Leningradskij Institut Yadernoj Fiziki imeni B. P. Konstantinova, Akademija Nauk S.S.S.R, Gatchina Leningradskoj Oblasti, 188350},\r\nabstract={Escherichia coli 70‐S ribosomes contain a third site for tRNA binding, additional to the A and P sites. This conclusion is based on several findings. Direct measurements showed that in the presence of poly(U), when both A and P sites are occupied by Ac[14C]Phe‐tRNAPhe, ribosomes are capable of binding additionally deacylated non‐cognate [3H]tRNA. If ribosomes in the preparation are active enough, the total binding of labeled ligands amounted to 2.5 mol/mol ribosomes. In the absence of poly(U), when the A site can not bind, the P site and the ‘additional’ site can be filled simultaneously with Ac[3C]Phe‐tRNAPhe and deacylated [3H]tRNA, or with [3H]tRNA alone; the total binding exceeds in this case 1.5 mol/mol ribosomes. The binding at the ‘additional’ site is not sensitive to the template. [3H]tRNA bound there is able to exchange rapidly for unlabeled tRNA in solution. Deacylated tRNA is prefered to the aminoacylated one. The binding of AcPhe‐tRNAPhe was not observed there at all. The 3′‐end adenosine is essential for the affinity. The function of the ‘additional’ site is not known, but its existence has to be considered when tRNA · ribosome complexes are studied. Copyright © 1982, Wiley Blackwell. All rights reserved},\r\ncorrespondence_address1={GRAJEVSKAJA, R.A.; Leningradskij Institut Yadernoj Fiziki imeni B. P. Konstantinova, Akademija Nauk S.S.S.R, Gatchina Leningradskoj Oblasti, 188350},\r\nissn={00142956},\r\npubmed_id={6184228},\r\nlanguage={English},\r\nabbrev_source_title={Eur. J. Biochem.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n\n\n

\n

\n \n 1981\n \n \n (1)\n \n \n

\n

\n \n \n

\n \n\n \n \n \n \n \n \n On the Mechanism of Interaction of N‐Acetylphenylalanyl‐tRNAPhe with Ribosomes of Escherichia coli Effect of Antibiotics and of TpΨpCpGp.\n \n \n \n \n\n\n \n IVANOV, Y.; GRAJEVSKAJA, R.; and SAMINSKY, E.\n\n\n \n\n\n\n European Journal of Biochemistry, 113(3): 457-461. 1981.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"On$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{IVANOV1981457,\r\nauthor={IVANOV, Y.V. and GRAJEVSKAJA, R.A. and SAMINSKY, E.M.},\r\ntitle={On the Mechanism of Interaction of N‐Acetylphenylalanyl‐tRNAPhe with Ribosomes of Escherichia coli Effect of Antibiotics and of TpΨpCpGp},\r\njournal={European Journal of Biochemistry},\r\nyear={1981},\r\nvolume={113},\r\nnumber={3},\r\npages={457-461},\r\ndoi={10.1111/j.1432-1033.1981.tb05085.x},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019450723&doi=10.1111%2fj.1432-1033.1981.tb05085.x&partnerID=40&md5=61420609ef1c446e0c2b1c3a0c7ec37e},\r\naffiliation={Leningradskij Institut Yadernoj Fiziki imeni, Akademija Nauk, S.S.S.R, Gatchina, 188350},\r\nabstract={The tetranucleotide TpΨpCpGp acts as a specific inhibitor of the rate of AcPhe‐tRNAPhe binding in the ribosomal P site. This effect is observed both in the presence and in the absence of poly(U). In the absence of poly(U) antibiotics tetracycline and puromycin also decrease the rate of AcPhe‐tRNAPhe binding. Some inhibition by tetracycline is observed with poly(U). All these inhibitors are known to be ligands of the ribosomal A site, and their influence on the P site binding can be most naturally explained by the suggestion that AcPhe‐tRNAPhe enters the ribosome via the A site, forms there an intermediate complex, and spontaneous translocation into the P site follows. In the presence of poly(U) arguments in favour of this hypothesis are much weaker, but the same sequence of events is possible. Copyright © 1981, Wiley Blackwell. All rights reserved},\r\ncorrespondence_address1={IVANOV, Y.V.; Leningradskij Institut Yadernoj Fiziki imeni, Akademija Nauk, S.S.S.R, Gatchina, 188350},\r\nissn={00142956},\r\npubmed_id={6163626},\r\nlanguage={English},\r\nabbrev_source_title={Eur. J. Biochem.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n\n\n\n

\n

\n \n 1980\n \n \n (5)\n \n \n

\n

\n \n \n

\n \n\n \n \n \n \n \n \n W-mutagenesis in competent cells of Bacillus subtilis.\n \n \n \n \n\n\n \n Bresler, S.; Kalinin, V.; and Kreneva, R.\n\n\n \n\n\n\n MGG Molecular & General Genetics, 177(4): 691-698. 1980.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"W-mutagenesis$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Bresler1980691,\r\nauthor={Bresler, S.E. and Kalinin, V.L. and Kreneva, R.A.},\r\ntitle={W-mutagenesis in competent cells of Bacillus subtilis},\r\njournal={MGG Molecular & General Genetics},\r\nyear={1980},\r\nvolume={177},\r\nnumber={4},\r\npages={691-698},\r\ndoi={10.1007/BF00272681},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018859663&doi=10.1007%2fBF00272681&partnerID=40&md5=2e3d4fa2260bce5a2ce08def66e02694},\r\naffiliation={Leningrad Institute of Nuclear Physics, Academy of Sciences of the USSR, Gatchina, Leningrad, 188350, Russia},\r\nabstract={The relative yield (Nm/N) of fluorescent mutants Ind- after the transformation of Bacillus subtilis cells by means of UV-irradiated DNA is much higher in an uvr- recipient than in an uvr+ strain, when compared at equal fluence, but practically identical at equal survival. Ind- mutations are induced by UV-irradiation of separated single strands of transforming DNA. The H-strand is much more sensitive to the mutagenic action of UV light. Preliminary irradiation of competent recipient cells by moderate UV fluences increases the survival of UV-or γ-irradiated transforming DNA (W-reactivation) and the frequency of Ind- mutations (W-mutagenesis). During transfection of B. subtilis cells by UV-irradiated prophage DNA isolated from lysogenic cells B. subtilis (Ø105 c+) c-mutants of the phage are obtained in high yield only in conditions of W-mutagenesis, i.e. in UV-irradiated recipient cells. These data show that there is no substantial spontaneous induction of error-prone SOS-repair system in the competent cells of B. subtilis. © 1980 Springer-Verlag.},\r\ncorrespondence_address1={Kalinin, V.L.; Leningrad Institute of Nuclear Physics, Academy of Sciences of the USSR, Gatchina, Leningrad, 188350, Russia},\r\npublisher={Springer-Verlag},\r\nissn={00268925},\r\ncoden={MGGEA},\r\npubmed_id={6770228},\r\nlanguage={English},\r\nabbrev_source_title={Molec. Gen. Genet.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Studies of the spontaneous transformation specificity in Bacillus subtilis. II. Genetic exchanges on solid media.\n \n \n \n \n\n\n \n Mosevitsky, M.; and Vinogradskaya, G.\n\n\n \n\n\n\n Genetika, 16(10): 1764-1774. 1980.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Studies$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Mosevitsky19801764,\r\nauthor={Mosevitsky, M.I. and Vinogradskaya, G.R.},\r\ntitle={Studies of the spontaneous transformation specificity in Bacillus subtilis. II. Genetic exchanges on solid media},\r\njournal={Genetika},\r\nyear={1980},\r\nvolume={16},\r\nnumber={10},\r\npages={1764-1774},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0019160968&partnerID=40&md5=07b1651af5470fd9c5bf401595db746e},\r\naffiliation={B.P. Konstantinov Leningrad Inst. Nucl. Phys., Acad. Sci. USSR, Leningrad, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\nlanguage={Russian},\r\nabbrev_source_title={GENETIKA},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n\n

\n\n\n

\n \n\n \n \n \n \n \n \n Quantitative Study of the Interaction of Formylmethionyl‐tRNAfMet with Ribosomes of Escherichia coli.\n \n \n \n \n\n\n \n IVANOV, Y.; GRAJEVSKAJA, R.; and SAMINSKY, E.\n\n\n \n\n\n\n European Journal of Biochemistry, 106(2): 449-456. 1980.\n cited By 4\n\n\n\n
\n\n\n\n \n \n $\"Quantitative$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{IVANOV1980449,\r\nauthor={IVANOV, Y.V. and GRAJEVSKAJA, R.A. and SAMINSKY, E.M.},\r\ntitle={Quantitative Study of the Interaction of Formylmethionyl‐tRNAfMet with Ribosomes of Escherichia coli},\r\njournal={European Journal of Biochemistry},\r\nyear={1980},\r\nvolume={106},\r\nnumber={2},\r\npages={449-456},\r\ndoi={10.1111/j.1432-1033.1980.tb04591.x},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018975060&doi=10.1111%2fj.1432-1033.1980.tb04591.x&partnerID=40&md5=9a22f862e23d6754881a4b6c0bb2388f},\r\naffiliation={Leningradskij Institut Yadernoj Fiziki imeni B. P. Konstantinova, Akademiya Nauk S.S.S.R, Gatchina, 188350},\r\nabstract={fMet‐tRNAfMet binds reversibly to the donor site (P‐site) of Escherichia coli ribosomes both in the absence of messenger and in the presence of ApUpGp and some other oligonucleotides or poly(U). Kinetics of interaction conforms the second‐order law. The equilibrium constants and the rate constants of binding are estimated at 0°C. Not only the cognate trinucleotide ApUpGp but also some other oligonucleotides and even poly(U) stimulate the binding. The presence of total deacylated tRNA considerably increases the selectivity of association. Copyright © 1980, Wiley Blackwell. All rights reserved},\r\ncorrespondence_address1={IVANOV, Y.V.; Leningradskij Institut Yadernoj Fiziki imeni B. P. Konstantinova, Akademiya Nauk S.S.S.R, Gatchina, 188350},\r\nissn={00142956},\r\npubmed_id={6995106},\r\nlanguage={English},\r\nabbrev_source_title={Eur. J. Biochem.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Effect of various polyribonucleotide interferonogens on acute and latent viral infections in mice.\n \n \n \n \n\n\n \n Vilner, L.; Kogan, E.; and Timkovsky, A.\n\n\n \n\n\n\n Voprosy Virusologii, 25(1): 67-71. 1980.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Effect$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Vilner198067,\r\nauthor={Vilner, L.M. and Kogan, E.M. and Timkovsky, A.L.},\r\ntitle={Effect of various polyribonucleotide interferonogens on acute and latent viral infections in mice},\r\njournal={Voprosy Virusologii},\r\nyear={1980},\r\nvolume={25},\r\nnumber={1},\r\npages={67-71},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018862656&partnerID=40&md5=5dad972692af81150011beeda6ac9f57},\r\naffiliation={Inst. Poliomielita Virus. Entsefal., AMN SSSR, Moscow},\r\nissn={05074088},\r\ncoden={VVIRA},\r\npubmed_id={7415152},\r\nlanguage={Russian},\r\nabbrev_source_title={VOPR. VIRUSOL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Predisintegration phenomena in CaF2 crystals activated by Europium, Manganese and Gadolinium.\n \n \n \n \n\n\n \n Orlov, Y.; Bozhevol'nov, V.; Ivanov, L.; Sluev, V.; Obyden, S.; Saparin, G.; Spivak, G.; and Karelin, V.\n\n\n \n\n\n\n Journal of Crystal Growth, 49(1): 109-114. 1980.\n cited By 4\n\n\n\n
\n\n\n\n \n \n $\"Predisintegration$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Orlov1980109,\r\nauthor={Orlov, Yu.N. and Bozhevol'nov, V.E. and Ivanov, L.N. and Sluev, V.I. and Obyden, S.K. and Saparin, G.V. and Spivak, G.V. and Karelin, V.V.},\r\ntitle={Predisintegration phenomena in CaF2 crystals activated by Europium, Manganese and Gadolinium},\r\njournal={Journal of Crystal Growth},\r\nyear={1980},\r\nvolume={49},\r\nnumber={1},\r\npages={109-114},\r\ndoi={10.1016/0022-0248(80)90069-X},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0012533334&doi=10.1016%2f0022-0248%2880%2990069-X&partnerID=40&md5=6a73e1ce46739c60ab187334fcd40b5a},\r\naffiliation={Chemistry Department, Moscow State University, Moscow, 117234, Russian Federation},\r\nabstract={The local impurity distribution in fluorite single crystals activated by europium, gadolinium and manganese has been studied with the aid of a scanning electron microscope. It is shown that the impurities in a crystal are distributed nonuniformly to form regions enriched and depleted with impurity. It is proved that the nonuniform distribution of activators due to disintegration processes of solid solutions and to the impurity redistribution occurring in the course of annealing of the crystals. The concentration stability limits of solid solutions in the CaF2-EuF2 and CaF2-MnF2 systems have been calculated. © 1980.},\r\ncorrespondence_address1={Orlov, Yu.N.; Chemistry Department, Moscow State University, Moscow, 117234, Russian Federation},\r\nissn={00220248},\r\ncoden={JCRGA},\r\nlanguage={English},\r\nabbrev_source_title={J Cryst Growth},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n\n\n\n

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\n \n 1979\n \n \n (2)\n \n \n

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\n \n \n

\n \n\n \n \n \n \n \n \n Studies of the spontaneous transformation specificity in bacteria Bacillus subtilis. I. Relatively low transformation activity of spontaneously released DNA for genetic markers placed in cell chromosome near the points of origin and termination of the chromosome replication.\n \n \n \n \n\n\n \n Vinogradskaya, G.; and Mosevitsky, M.\n\n\n \n\n\n\n Genetika, 15(11): 1911-1917. 1979.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Studies$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Vinogradskaya19791911,\r\nauthor={Vinogradskaya, G.R. and Mosevitsky, M.I.},\r\ntitle={Studies of the spontaneous transformation specificity in bacteria Bacillus subtilis. I. Relatively low transformation activity of spontaneously released DNA for genetic markers placed in cell chromosome near the points of origin and termination of the chromosome replication},\r\njournal={Genetika},\r\nyear={1979},\r\nvolume={15},\r\nnumber={11},\r\npages={1911-1917},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018614311&partnerID=40&md5=6297cffbe248875fe61ea61891116327},\r\naffiliation={B.P. Konstantinov Leningrad Inst. Nucl. Phys., Acad. Scis USSR, Gatchina, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={116902},\r\nlanguage={Russian},\r\nabbrev_source_title={GENETIKA},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Hydrolysis and inactivation of double-stranded polyribonucleotide complexes with monkey blood serum.\n \n \n \n \n\n\n \n Vilner, L.; Timkovsky, A.; and Kogan, E.\n\n\n \n\n\n\n Voprosy Virusologii, 24(2): 181-185. 1979.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"Hydrolysis$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Vilner1979181,\r\nauthor={Vilner, L.M. and Timkovsky, A.L. and Kogan, E.M.},\r\ntitle={Hydrolysis and inactivation of double-stranded polyribonucleotide complexes with monkey blood serum},\r\njournal={Voprosy Virusologii},\r\nyear={1979},\r\nvolume={24},\r\nnumber={2},\r\npages={181-185},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0018379623&partnerID=40&md5=9cb9155843867689ef9464e3c36f93e7},\r\naffiliation={Inst. Poliomieolita Virus. Entsefal., AMN SSSR, Moscow},\r\nissn={05074088},\r\ncoden={VVIRA},\r\npubmed_id={107655},\r\nlanguage={Russian},\r\nabbrev_source_title={VOPR. VIRUSOL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1978\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n On the mechanism of raising the transfection efficiency of lysogenic or infected with helper phage calcinated Escherichia coli cells with λ DNA.\n \n \n \n \n\n\n \n Drabkina, L.; Konevega, L.; Legina, O.; and Mosevitsky, M.\n\n\n \n\n\n\n Genetika, 14(7): 1153-1163. 1978.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"On$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Drabkina19781153,\r\nauthor={Drabkina, L.E. and Konevega, L.V. and Legina, O.K. and Mosevitsky, M.I.},\r\ntitle={On the mechanism of raising the transfection efficiency of lysogenic or infected with helper phage calcinated Escherichia coli cells with λ DNA},\r\njournal={Genetika},\r\nyear={1978},\r\nvolume={14},\r\nnumber={7},\r\npages={1153-1163},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017833035&partnerID=40&md5=e7b4618ec48d0cca88002fe770910ab6},\r\naffiliation={B.P. Konstantinov Inst. Nucl. Phys., Acad. Scis USSR, Leningrad, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={352809},\r\nlanguage={Russian},\r\nabbrev_source_title={GENETIKA},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Antiviral activity of complexes obtained at different ratios of complemental homopolyribonucleotides.\n \n \n \n \n\n\n \n Novokhatsky, A.; Kogan, E.; and Timkovsky, A.\n\n\n \n\n\n\n Antibiotiki, 23(5): 406-411. 1978.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Antiviral$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Novokhatsky1978406,\r\nauthor={Novokhatsky, A.S. and Kogan, E.M. and Timkovsky, A.L.},\r\ntitle={Antiviral activity of complexes obtained at different ratios of complemental homopolyribonucleotides},\r\njournal={Antibiotiki},\r\nyear={1978},\r\nvolume={23},\r\nnumber={5},\r\npages={406-411},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017902362&partnerID=40&md5=54e9fe4ba102016282db2f93c438ccdc},\r\naffiliation={D.I. Ivanovsky Virol. Inst., USSR Acad. Med. Sci., Moscow},\r\ncoden={ANTBA},\r\npubmed_id={655685},\r\nlanguage={Russian},\r\nabbrev_source_title={ANTIBIOTIKI},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n\n\n\n

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\n \n 1977\n \n \n (2)\n \n \n

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\n \n\n \n \n \n \n \n \n Thymidine Uptake in Bacteria: The Effect of Purine Nucleosides.\n \n \n \n \n\n\n \n VYACHESLAVOV, L.; and MOSEVITSKY, M.\n\n\n \n\n\n\n European Journal of Biochemistry, 74(2): 313-318. 1977.\n cited By 6\n\n\n\n
\n\n\n\n \n \n $\"Thymidine$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{VYACHESLAVOV1977313,\r\nauthor={VYACHESLAVOV, L.G. and MOSEVITSKY, M.I.},\r\ntitle={Thymidine Uptake in Bacteria: The Effect of Purine Nucleosides},\r\njournal={European Journal of Biochemistry},\r\nyear={1977},\r\nvolume={74},\r\nnumber={2},\r\npages={313-318},\r\ndoi={10.1111/j.1432-1033.1977.tb11395.x},\r\nnote={cited By 6},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017600220&doi=10.1111%2fj.1432-1033.1977.tb11395.x&partnerID=40&md5=1874de29dbe7e5dc4cd69264ca6b2416},\r\naffiliation={Laboratoriya Biopolimerov, Leningradskij lnstitut Yadernoj Fiziki, Akademia Nauk S.S.S.R., Gatchina, 188350},\r\nabstract={The kinetics of thymidine uptake by Escherichia coli and Bacillus subtilis cells in the presence of adenine and guanine nucleosides was investigated. The initial concentration of thymidine in the growth medium was 0.35 ug/ml while the initial concentration of purine nucleosides ranged from 25 to 250 ug/ml. Adenine nucleosides when present at a concentration more than 50 ug/ml. strongly inhibit thymidine uptake by the bacteria. The duration of the inhibition depends on the initial concentration of adenine nucleoside in the growth medium. At an initial con‐centration of deoxyadenosine (or adenosine) of 250 ug/ml the time of inhibition of thymidine uptake was about 60 min. During this period thymidine is almost completely preserved from the action of bacterial thymidine phosphorylase. Guanine nucleosides (guanosine or deoxyguanosine) do not markedly inhibit thymidine uptake by bacteria even at a concentration of 250 ug/ml. It is shown that they do protect thymidine from the phosphorolytic action of the thymidine phosphorylase although much less effectively than adenine nucleosides. It is suggested that some areas in the bacterial membrane where thymidine phosphorylase is located are not available to guanine nucleosides. Copyright © 1977, Wiley Blackwell. All rights reserved},\r\ncorrespondence_address1={VYACHESLAVOV, L.G.; Laboratoriya Biopolimerov, Leningradskij lnstitut Yadernoj Fiziki, Akademia Nauk S.S.S.R., Gatchina, 188350},\r\nissn={00142956},\r\npubmed_id={404148},\r\nlanguage={English},\r\nabbrev_source_title={Eur. J. Biochem.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n W reactivation and W mutagenesis of UV irradiated phage phi 105 of Bacillus subtilis.\n \n \n \n \n\n\n \n Kalinin, V.; and Kreneva, R.\n\n\n \n\n\n\n Genetika, 13(7): 1268-1280. 1977.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"W$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Kalinin19771268,\r\nauthor={Kalinin, V.L. and Kreneva, R.A.},\r\ntitle={W reactivation and W mutagenesis of UV irradiated phage phi 105 of Bacillus subtilis},\r\njournal={Genetika},\r\nyear={1977},\r\nvolume={13},\r\nnumber={7},\r\npages={1268-1280},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017366081&partnerID=40&md5=3b7c39a021e1e1df7527978798e61d40},\r\naffiliation={B. P. Konstantinov Leningrad Inst. Nucl Phys., Acad. Sci. USSR, Leningrad, Russian Federation},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={410700},\r\nlanguage={Russian},\r\nabbrev_source_title={GENETIKA},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1976\n \n \n (6)\n \n \n

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\n \n\n \n \n \n \n \n \n Interaction of transfer RNA with 50S ribosomal subunits of Escherichia coli in absence of templates.\n \n \n \n \n\n\n \n Bresler, S.; Graevskaya, R.; Ivanov, Y.; and Saminskii, E.\n\n\n \n\n\n\n Molekulyarnaya Biologiya, 10(4): 640-646. 1976.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Interaction$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler1976640,\r\nauthor={Bresler, S.E. and Graevskaya, R.A. and Ivanov, Y.V. and Saminskii, E.M.},\r\ntitle={Interaction of transfer RNA with 50S ribosomal subunits of Escherichia coli in absence of templates.},\r\njournal={Molekulyarnaya Biologiya},\r\nyear={1976},\r\nvolume={10},\r\nnumber={4},\r\npages={640-646},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0016978405&partnerID=40&md5=f44500f6dfd3884a3ccf7d3295607b2d},\r\nabstract={The equilibrium constant of a complex of tRNA with the 50S ribosomal subunit was measured in the absence of a template. It was shown that the stability of the complex increases with an increase in the concentration of Mg2+, it decreases with an increase in the concentration of univalent ions, and does not depend on the pH of the medium in the range of 7.0-8.2. Removal of the 3'-terminal nucleoside of tRNA weakens the association approximately 40-fold; the subsequent successive splitting off of another three nucleotides has little effect on the association constant. In 90% 2H2O the stability of the complex increases approximately four-fold, which points to the large contribution of the hydrogen bonds to the free energy of the interaction. The tetranucleotide TphiCG competes slightly with tRNA for sites on the 50S subparticles; this means that the TphiC segment of tRNA does not play an important role in the formation of the complex under investigation.},\r\ncorrespondence_address1={Bresler, S.E.},\r\nissn={00268984},\r\npubmed_id={15209},\r\nlanguage={English},\r\nabbrev_source_title={Mol Biol (Mosk)},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Visualization of sister strand exchanges induced by ultraviolet irradiation.\n \n \n \n \n\n\n \n Mosevitsky, M.\n\n\n \n\n\n\n Journal of Molecular Biology, 100(2): 219-225. 1976.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Visualization$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Mosevitsky1976219,\r\nauthor={Mosevitsky, M.I.},\r\ntitle={Visualization of sister strand exchanges induced by ultraviolet irradiation},\r\njournal={Journal of Molecular Biology},\r\nyear={1976},\r\nvolume={100},\r\nnumber={2},\r\npages={219-225},\r\ndoi={10.1016/S0022-2836(76)80150-7},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017288443&doi=10.1016%2fS0022-2836%2876%2980150-7&partnerID=40&md5=f57ef011c63ca5cedf222786044af267},\r\naffiliation={Laboratory of Biopolymers Institute, Nuclear Physics Academy of Sciences of U.S.S.R. Leningrad, Gatchina, 188350, Russian Federation},\r\nabstract={To visualize ultraviolet-induced sister strand exchanges electron microscope autoradiography was used. Escherichia coli strain AB2500 uvr A 6 Rec+, incapable of excising pyrimidine dimers in DNA was labelled with [methyl-3H]thymidine (28 Ci/mmol) during one cycle of semiconservative replication, then irradiated with ultraviolet light (dose 40 ergs/mm2) and incubated in non-radioactive medium for 100 minutes. By means of electron microscope autoradiography the exchanged areas, mostly shorter than 1 μm, were observed in DNA isolated from these cells. The number of visualized exchanges comprises 10 to 15% of pyrimidine dimers. In DNA from non-irradiated cells the exchanges were observed much less frequently than in DNA from ultraviolet-irradiated cells. These results confirm the suggestion that ultraviolet light induces sister exchanges in bacteria, which can be involved in post-replication repair. © 1976 Academic Press Inc. (London) Limited.},\r\ncorrespondence_address1={Mosevitsky, M.I.; Laboratory of Biopolymers Institute, Nuclear Physics Academy of Sciences of U.S.S.R. Leningrad, Gatchina, 188350, Russian Federation},\r\nissn={00222836},\r\ncoden={JMOBA},\r\npubmed_id={768483},\r\nlanguage={English},\r\nabbrev_source_title={J. Mol. Biol.},\r\ndocument_type={Letter},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n The detailed model of semiconservative DNA replication. Possible role of DNA polymerase mistakes in discontinuous copying of both matrix strands (Russian).\n \n \n \n \n\n\n \n Mosevitsky, M.\n\n\n \n\n\n\n Genetika, 12(9): 154-163. 1976.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Mosevitsky1976154,\r\nauthor={Mosevitsky, M.I.},\r\ntitle={The detailed model of semiconservative DNA replication. Possible role of DNA polymerase mistakes in discontinuous copying of both matrix strands (Russian)},\r\njournal={Genetika},\r\nyear={1976},\r\nvolume={12},\r\nnumber={9},\r\npages={154-163},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017223523&partnerID=40&md5=f41bd2c95b9d86f50e52e81f9152e9c3},\r\naffiliation={B.P. Konstantinov Leningrad Inst. Nucl. Phys., Acad. Sci. USSR, Leningrad, Russian Federation},\r\nabstract={A model of semiconservative DNA synthesis is considered. The model is based on a suggestion that the synthesis proceeds in the course of one directional stretching of both matrix strands through the replicase complex (replisome), or of one directional movement of the replisome along the chromosome. Each nucleotide link of the matrix strand finds itself successively in the section of RNA primer synthesis, in the section of DNA polymerase and in the control section of a proofreading 3'→5' exonuclease. Deoxynucleoside incorrectly joined by DNA polymerase of the replisome to the 3' OH end of growing chain are, as a rule, removed when transferred in the control section. Since the reverse movemen is prohibited, the DNA polymerase loses the 3' OH end of new DNA chain and proves to be incapable of continuing the synthesis. It can be renewed only after a new RNA primer formation. For continuation of the DNA synthesis after an incorrect deoxynucleotide addition, replicase must make two more mistakes in succession: to retain the incorrect nucleotide and to join the next one to this unproperly arranged primer. Only in that case can the non complementary nucleotide in a new DNA chain escape the action of proofreading exonucleases. Hence, according to the model under discussion, the frequency of mutations should be many times lower than that of incorrect nucleotide joinings. The latter results, as a rule, in DNA chain synthesis cessation and in fragments formation. Taking into consideration the frequency of spontaneous mutations in bacteria (about 10-9 per base pair), the frequency of non complementary joinings during semiconservative synthesis can be suggested of the order 10-3 in accordance with the average Okazaki fragments size of 1000 nucleotides. Another possible reason for periodical interruptions of semiconservative DNA synthesis and for fragments formation is a distortion of replisome structure, accompanying the release of the matrix strand being copied in the direction of already replicated chromosome region. Both mechanisms can participate concurrently in DNA fragments formation. If replisomes are attached to a cell membrane, the sites of chromosome that are also fastened in the membrane, in particular, the site of 'origin', are to be replicated using some mobile replicase complex.},\r\nissn={00166758},\r\ncoden={GNKAA},\r\npubmed_id={795718},\r\nlanguage={Russian},\r\nabbrev_source_title={GENETIKA},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

\n

\n\n\n

\n A model of semiconservative DNA synthesis is considered. The model is based on a suggestion that the synthesis proceeds in the course of one directional stretching of both matrix strands through the replicase complex (replisome), or of one directional movement of the replisome along the chromosome. Each nucleotide link of the matrix strand finds itself successively in the section of RNA primer synthesis, in the section of DNA polymerase and in the control section of a proofreading 3'→5' exonuclease. Deoxynucleoside incorrectly joined by DNA polymerase of the replisome to the 3' OH end of growing chain are, as a rule, removed when transferred in the control section. Since the reverse movemen is prohibited, the DNA polymerase loses the 3' OH end of new DNA chain and proves to be incapable of continuing the synthesis. It can be renewed only after a new RNA primer formation. For continuation of the DNA synthesis after an incorrect deoxynucleotide addition, replicase must make two more mistakes in succession: to retain the incorrect nucleotide and to join the next one to this unproperly arranged primer. Only in that case can the non complementary nucleotide in a new DNA chain escape the action of proofreading exonucleases. Hence, according to the model under discussion, the frequency of mutations should be many times lower than that of incorrect nucleotide joinings. The latter results, as a rule, in DNA chain synthesis cessation and in fragments formation. Taking into consideration the frequency of spontaneous mutations in bacteria (about 10-9 per base pair), the frequency of non complementary joinings during semiconservative synthesis can be suggested of the order 10-3 in accordance with the average Okazaki fragments size of 1000 nucleotides. Another possible reason for periodical interruptions of semiconservative DNA synthesis and for fragments formation is a distortion of replisome structure, accompanying the release of the matrix strand being copied in the direction of already replicated chromosome region. Both mechanisms can participate concurrently in DNA fragments formation. If replisomes are attached to a cell membrane, the sites of chromosome that are also fastened in the membrane, in particular, the site of 'origin', are to be replicated using some mobile replicase complex.\n

\n\n\n

\n \n\n \n \n \n \n \n \n The absence of histone H1 from the chromatin fraction obtained by sonication of calf thymus nuclei under 'quasiphysiological' ionic conditions.\n \n \n \n \n\n\n \n Lishanskaya, A.; and Mosevitsky, M.\n\n\n \n\n\n\n Nucleic Acids Research, 3(8): 2041-2054. 1976.\n cited By 4\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Lishanskaya19762041,\r\nauthor={Lishanskaya, A.I. and Mosevitsky, M.I.},\r\ntitle={The absence of histone H1 from the chromatin fraction obtained by sonication of calf thymus nuclei under 'quasiphysiological' ionic conditions},\r\njournal={Nucleic Acids Research},\r\nyear={1976},\r\nvolume={3},\r\nnumber={8},\r\npages={2041-2054},\r\ndoi={10.1093/nar/3.8.2041},\r\nnote={cited By 4},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017136815&doi=10.1093%2fnar%2f3.8.2041&partnerID=40&md5=49732757580d976ee614325701d758a4},\r\naffiliation={Lab. Biopolymers, Inst. Nucl. Phys., Acad. Sci. USSR, Leningrad, Russian Federation},\r\nabstract={The minor chromatin fraction was isolated from the sonicated calf thymus nuclei on the basis of its differential solubility in the 'quasiphysiological' salt medium (0.1 M KCl 0.05 M NaCl 1 mM MgCl2 mM CaCl2). Histone H1 is almost completely absent from this fraction. DNA isolated from this fraction occurs in three discrete low mol. wt. fragments. The fraction of chromatin which lacks histone H1 can also be obtained by two other methods. One of them consist in salt precipitation of the chromatin gel and its subsequent sonication. The second method includes precipitation of the sonicated chromatin gel by salts. In the first case the properties of the chromatin fraction which remains in the supernatant after centrifugation closely resemble those of the original salt soluble nuclear fraction. The second method yields supernatant fraction also lacking histone H1 but containing heterogeneous DNA. Comparisons were also made of the sonically solubilized nuclear fractions obtained in the complete salt medium and its mono and divalent cationic constituents.},\r\nissn={03051048},\r\ncoden={NARHA},\r\npubmed_id={967688},\r\nlanguage={English},\r\nabbrev_source_title={NUCLEIC ACIDS RES.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Dependence of transfection efficiency of calcium treated Escherichia coli cells on bacterial genotype and form of lambda DNA.\n \n \n \n \n\n\n \n Drabkina, L.; Konevega, L.; Legina, O.; and Mosevitsky, M.\n\n\n \n\n\n\n MGG Molecular & General Genetics, 144(1): 83-86. 1976.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"Dependence$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Drabkina197683,\r\nauthor={Drabkina, L.E. and Konevega, L.V. and Legina, O.K. and Mosevitsky, M.I.},\r\ntitle={Dependence of transfection efficiency of calcium treated Escherichia coli cells on bacterial genotype and form of lambda DNA},\r\njournal={MGG Molecular & General Genetics},\r\nyear={1976},\r\nvolume={144},\r\nnumber={1},\r\npages={83-86},\r\ndoi={10.1007/BF00277309},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017276873&doi=10.1007%2fBF00277309&partnerID=40&md5=92b1c9e0c5d7cb8ac9517c32c8308b64},\r\naffiliation={Institute of Nuclear Physics, Academy of Sciences of the USSR, Leningrad, Russia},\r\nabstract={The transfecting activity of linear λ DNA is 100 times higher in calcium treated E. coli K 12 (λi434) than in non-lysogenic strains: the levels of transfection are 1-2.107 and 1-2.105 infective centers per 1 μg of λ DNA, respectively. The high efficiency of lysogenic cells transfection is not due to the spontaneously liberated "helper" phage. Evidently, it is called forth by transfecting DNA-prophage recombination or/and by inhibition of nuclease activity in lysogenic cells. Both ring forms λ DNA (supercoiled and open circles) show very low infectivity, if any, in calcinated cells. © 1976 Springer-Verlag.},\r\ncorrespondence_address1={Drabkina, L.E.; Institute of Nuclear Physics, Academy of Sciences of the USSR, Leningrad, Russia},\r\npublisher={Springer-Verlag},\r\nissn={00268925},\r\ncoden={MGGEA},\r\npubmed_id={772416},\r\nlanguage={English},\r\nabbrev_source_title={Molec. Gen. Genet.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Mutagenic action of γ-rays on transforming DNA of Bacillus subtilis.\n \n \n \n \n\n\n \n Kreneva, R.; Bresler, S.; Kalilin, V.; and Shelegedin, V.\n\n\n \n\n\n\n Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 34(3): 527-531. 1976.\n cited By 2\n\n\n\n
\n\n\n\n \n \n $\"Mutagenic$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Kreneva1976527,\r\nauthor={Kreneva, R.A. and Bresler, S.E. and Kalilin, V.L. and Shelegedin, V.N.},\r\ntitle={Mutagenic action of γ-rays on transforming DNA of Bacillus subtilis},\r\njournal={Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis},\r\nyear={1976},\r\nvolume={34},\r\nnumber={3},\r\npages={527-531},\r\ndoi={10.1016/0027-5107(76)90227-X},\r\nnote={cited By 2},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0017159238&doi=10.1016%2f0027-5107%2876%2990227-X&partnerID=40&md5=7cb8e26f63a70d92a7ed108f8556b121},\r\naffiliation={Leningrad Nuclear Physics Institute, Academy of Sciences, the USSR, Gatchina, Leningrad district 188350, Russian Federation},\r\ncorrespondence_address1={Kreneva, R.A.; Leningrad Nuclear Physics Institute, Academy of Sciences, the USSR, Gatchina, Leningrad district 188350, Russian Federation},\r\nissn={00275107},\r\ncoden={MRFME},\r\npubmed_id={817198},\r\nlanguage={English},\r\nabbrev_source_title={Mutat. Res. Fundam. Mol. Mech. Mutagen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1975\n \n \n (3)\n \n \n

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\n \n\n \n \n \n \n \n \n Double stranded complex of polyguanylic and polycytidylic acids and its antiviral activity in tissue culture.\n \n \n \n \n\n\n \n Novokhatsky, A.; Ershov, F.; Timkovsky, A.; Bresler, S.; Kogan, E.; and Tikhomirova-Sidorova, N.\n\n\n \n\n\n\n Acta Virologica, 19(2): 121-129. 1975.\n cited By 9\n\n\n\n
\n\n\n\n \n \n $\"Double$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Novokhatsky1975121,\r\nauthor={Novokhatsky, A.S. and Ershov, F.I. and Timkovsky, A.L. and Bresler, S.E. and Kogan, E.M. and Tikhomirova-Sidorova, N.S.},\r\ntitle={Double stranded complex of polyguanylic and polycytidylic acids and its antiviral activity in tissue culture},\r\njournal={Acta Virologica},\r\nyear={1975},\r\nvolume={19},\r\nnumber={2},\r\npages={121-129},\r\nnote={cited By 9},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0016694137&partnerID=40&md5=062a28275d0128ec89555a75f5f874c0},\r\naffiliation={D.I. Ivanovsky Inst. Virol., USSR Acad. Med. Sci., Moscow, Russian Federation},\r\nissn={0001723X},\r\ncoden={AVIRA},\r\npubmed_id={239557},\r\nlanguage={English},\r\nabbrev_source_title={ACTA VIROL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Study of calf thymus deoxyribonucleoproteins by means of gel electrophoresis, effect of ionic composition on the mode of chromatin fragmentation.\n \n \n \n \n\n\n \n Lishanskaya, A.; and Mosevitsky, M.\n\n\n \n\n\n\n Biochemical and Biophysical Research Communications, 62(4): 822-829. 1975.\n cited By 9\n\n\n\n
\n\n\n\n \n \n $\"Study$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Lishanskaya1975822,\r\nauthor={Lishanskaya, A.I. and Mosevitsky, M.I.},\r\ntitle={Study of calf thymus deoxyribonucleoproteins by means of gel electrophoresis, effect of ionic composition on the mode of chromatin fragmentation},\r\njournal={Biochemical and Biophysical Research Communications},\r\nyear={1975},\r\nvolume={62},\r\nnumber={4},\r\npages={822-829},\r\ndoi={10.1016/0006-291X(75)90396-4},\r\nnote={cited By 9},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0016658072&doi=10.1016%2f0006-291X%2875%2990396-4&partnerID=40&md5=bf47f26673189dee7d23b51a16d9e8df},\r\naffiliation={Laboratory of Biopolymers, Institute of Nuclear Physics, Academy of Sciences, Leningrad, Gatchina 188350, Russian Federation},\r\nabstract={Calf thymus soluble deoxyribonucleoproteins (DNP) obtained by sonication of chromatins isolated both in a "physiological" salt medium and in a buffered water were resolved into four fractions on electrophoresis. The DNA extracted from DNP obtained in a salt medium occurs in fragments of discrete sizes while the sonicated chromatin gel obtained in a buffered water gives rise to a heterogeneous population of DNA fragments upon deproteinization. It is suggested that regularly spaced "weak" points exist in native chromatin and that the regularity is destroyed during isolation procedures involving the transfer of the nuclei into water. © 1975.},\r\ncorrespondence_address1={Lishanskaya, A.I.; Laboratory of Biopolymers, Institute of Nuclear Physics, Academy of Sciences, Leningrad, Gatchina 188350, Russian Federation},\r\nissn={0006291X},\r\ncoden={BBRCA},\r\npubmed_id={1120085},\r\nlanguage={English},\r\nabbrev_source_title={Biochem. Biophys. Res. Commun.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Infectivity of different forms of DNA of phage lambda in transfection of calcinated Escherichia coli cells (Russian).\n \n \n \n \n\n\n \n Drabkina, L.; Konevega, L.; Legina, O.; and Mosevitsky, M.\n\n\n \n\n\n\n Molekulyarnaya Biologiya, 9(3): 370-377. 1975.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Infectivity$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Drabkina1975370,\r\nauthor={Drabkina, L.E. and Konevega, L.V. and Legina, O.I. and Mosevitsky, M.I.},\r\ntitle={Infectivity of different forms of DNA of phage lambda in transfection of calcinated Escherichia coli cells (Russian)},\r\njournal={Molekulyarnaya Biologiya},\r\nyear={1975},\r\nvolume={9},\r\nnumber={3},\r\npages={370-377},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0016781995&partnerID=40&md5=e47c9b4907af93746b31a2602fd3da79},\r\naffiliation={Inst. Nucl. Phys., Acad. Sci. USSR, Gatchina},\r\nissn={00268984},\r\ncoden={MOBIB},\r\npubmed_id={765769},\r\nlanguage={Russian},\r\nabbrev_source_title={MOL. BIOL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1974\n \n \n (2)\n \n \n

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\n \n \n

\n \n\n \n \n \n \n \n \n Synthesis and electron microscopic investigation of model polyacryloylnucleosides.\n \n \n \n \n\n\n \n Mosevitsky, M.; and Panarin, E.\n\n\n \n\n\n\n Biopolymers, 13(1): 185-192. 1974.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Synthesis$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Mosevitsky1974185,\r\nauthor={Mosevitsky, M.I. and Panarin, E.F.},\r\ntitle={Synthesis and electron microscopic investigation of model polyacryloylnucleosides},\r\njournal={Biopolymers},\r\nyear={1974},\r\nvolume={13},\r\nnumber={1},\r\npages={185-192},\r\ndoi={10.1002/bip.1974.360130112},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0016378868&doi=10.1002%2fbip.1974.360130112&partnerID=40&md5=711f677c3c1bbf0efd00f48a5cc11d8a},\r\naffiliation={Laboratory of Biopolymers, Leningrad Institute of Nuclear Physics, Academy of Sciences of U.S.S.R, Gatchina, Leningrad, 188350; Institute of High Molecular Weight Compounds, Academy of Sciences of U.S.S.R, Leningrad, 199004},\r\nabstract={Using the interaction of polyacrylic anhydride with uridine or N‐acetyl derivatives of adenosine, cytidine, and guanosine, the water‐soluble copolymers, polyacryloylnucleosides, were obtained. The acryloylnucleoside units to acrylic acid units ratio in the copolymer was usually about 1:20. The attaching of nucleosides to the polymer occurs mostly through the 5′‐hydroxyl group of the sugar. The prominent feature of all polyacryloylnucleosides obtained is their fibrous structure at an ionic strength 0.2 and neutral pH. At concentrations <200 μg/ml the separate strands with a length of 0.2–1.0 μ and diameter of 30–40 Å are distinguishable. Evidently they are formed by side association of two molecules of copolymer or by folding of one molecule on itself. At higher concentrations branched multistranded structures are formed. In the same conditions polyacrylic acid alone does not form the fibrous structures. Heating of polyacryloylnucleoside solutions at 100°C and fast cooling in ice water, or raising of the pH to 12 turned the stranded structures to coils. After annealing or neutralization the stranded structures reformed. These transformations are similar to those which occur with nucleic acids. The results show that the fibrous structure of the copolymers depends on the hydrogen bonds formed by purine and/or pyrimidine bases. Copyright © 1974 John Wiley & Sons, Inc.},\r\ncorrespondence_address1={Mosevitsky, M.I.; Laboratory of Biopolymers, Leningrad Institute of Nuclear Physics, Academy of Sciences of U.S.S.R, Gatchina, Leningrad, 188350},\r\nissn={00063525},\r\npubmed_id={4818126},\r\nlanguage={English},\r\nabbrev_source_title={Biopolymers},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Mutations as replication errors in bacteria growing under conditions of thymine deficiency (Russian).\n \n \n \n \n\n\n \n Bresler, S.; Mosevitsky, M.; and Vyacheslavov, L.\n\n\n \n\n\n\n Molekulyarnaya Biologiya, 8(2): 171-181. 1974.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"Mutations$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Bresler1974171,\r\nauthor={Bresler, S.E. and Mosevitsky, M.I. and Vyacheslavov, L.G.},\r\ntitle={Mutations as replication errors in bacteria growing under conditions of thymine deficiency (Russian)},\r\njournal={Molekulyarnaya Biologiya},\r\nyear={1974},\r\nvolume={8},\r\nnumber={2},\r\npages={171-181},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0015972424&partnerID=40&md5=c2b62ca4e0e95ab40a0855f5db9335d4},\r\naffiliation={B.P. Konstantinov Inst. Nucl. Phys., Acad. Sci. USSR, Leningrad},\r\nissn={00268984},\r\ncoden={MOBIB},\r\nlanguage={Russian},\r\nabbrev_source_title={MOL. BIOL.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1973\n \n \n (2)\n \n \n

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\n \n \n

\n \n\n \n \n \n \n \n \n Size dependent separation of high molecular weight double-stranded DNA by means of gel electrophoresis.\n \n \n \n \n\n\n \n Lishanskaya, A.; and Mosevitsky, M.\n\n\n \n\n\n\n Biochemical and Biophysical Research Communications, 52(4): 1213-1220. 1973.\n cited By 19\n\n\n\n
\n\n\n\n \n \n $\"Size$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Lishanskaya19731213,\r\nauthor={Lishanskaya, A.I. and Mosevitsky, M.I.},\r\ntitle={Size dependent separation of high molecular weight double-stranded DNA by means of gel electrophoresis},\r\njournal={Biochemical and Biophysical Research Communications},\r\nyear={1973},\r\nvolume={52},\r\nnumber={4},\r\npages={1213-1220},\r\ndoi={10.1016/0006-291X(73)90629-3},\r\nnote={cited By 19},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0015902978&doi=10.1016%2f0006-291X%2873%2990629-3&partnerID=40&md5=bdf9b7841891f040d007ec1b2c5301ba},\r\naffiliation={Institute of Nuclear Physics, the Academy of Sciences, USSR, 2-nd Birjevoy 6, Leningrad, 199164, Russian Federation},\r\nabstract={The molecular weight dependence of the electrophoretic mobility of high molecular weight double-stranded DNA in agarose-polyacrylamide composite gels was investigated. This dependence is much more pronounced at low voltage gradients. The mobility of relatively low molecular weight DNA samples (8×106) in rather diluted gels is higher and in more concentrated gels is lower than that of high molecular weight DNA (31×106 and 120×106). It was found that at low voltage gradients the mobility of DNA drastically decreases. These results are interpreted in terms of flexible polymer chains statistics taking into account the elastic deformation of DNA coils migrating through the gel pores. © 1973.},\r\ncorrespondence_address1={Lishanskaya, A.I.; Institute of Nuclear Physics, the Academy of Sciences, USSR, 2-nd Birjevoy 6, Leningrad, 199164, Russian Federation},\r\nissn={0006291X},\r\ncoden={BBRCA},\r\npubmed_id={4197957},\r\nlanguage={English},\r\nabbrev_source_title={Biochem. Biophys. Res. Commun.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n

\n \n\n \n \n \n \n \n \n Mutations as possible replication errors in bacteria growing under conditions of thymine deficiency.\n \n \n \n \n\n\n \n Bresler, S.; Mosevitsky, M.; and Vyacheslavov, L.\n\n\n \n\n\n\n Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 19(3): 281-293. 1973.\n cited By 23\n\n\n\n
\n\n\n\n \n \n $\"Mutations$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

\n

@ARTICLE{Bresler1973281,\r\nauthor={Bresler, S.E. and Mosevitsky, M.I. and Vyacheslavov, L.G.},\r\ntitle={Mutations as possible replication errors in bacteria growing under conditions of thymine deficiency},\r\njournal={Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis},\r\nyear={1973},\r\nvolume={19},\r\nnumber={3},\r\npages={281-293},\r\ndoi={10.1016/0027-5107(73)90228-5},\r\nnote={cited By 23},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0015842943&doi=10.1016%2f0027-5107%2873%2990228-5&partnerID=40&md5=054c0a8e4e43993aad4864f34a38e8c2},\r\naffiliation={Laboratory of Biopolymers, Leningrad Institute of Nuclear Physics, the Academy of Sciences, Birjevoy 6, Leningrad, 199164, Russian Federation},\r\nabstract={When Escherichia coli or Bacillus subtilis cells having inhibited thymidylate synthetase activity were incubated for a long time on solid medium supplemented with a limiting concentration of thymine or thymidine (0.1-0.3 μg/ml) most of them became mutants for one or more genetic markers. This "overall mutagenesis" was detected both in Thy- bacteria and in prototrophs for thymine (Thy+) with thymidylate synthetase inhibited by the addition of 5-fluorodeoxyuridine (FUdR) to the growth medium. When thymine (or thymidine) was present in very low amounts (10-3 μg/ml) or was totally absent, the efficiency of mutagenesis decreased some 100-fold. The solid growth medium is essential because it supports the filamentous cells grown under conditions of limiting thymine. For some of the mutants with identified deficiency their ability to revert under the action of different mutagens was studied. Most efficient was 5-bromouracil (BU). This reversion is the characteristic response of mutations due to AT → GC transitions. In addition to single mutants, many multiple mutants were induced. The repair-defective strain of E. coli pol A1- and strains Rec A- and Exr A-, which are also defective in UV-induced mutagenesis, showed a high level of mutation induction under the conditions described. All these results are in accord with the hypothesis that overall low-thymine mutagenesis reflects the accumulation of replication errors in DNA under the conditions of a precursor deficiency. © 1973.},\r\ncorrespondence_address1={Bresler, S.E.; Laboratory of Biopolymers, Leningrad Institute of Nuclear Physics, the Academy of Sciences, Birjevoy 6, Leningrad, 199164, Russian Federation},\r\nissn={00275107},\r\ncoden={MRFME},\r\npubmed_id={4201996},\r\nlanguage={English},\r\nabbrev_source_title={Mutat. Res. Fundam. Mol. Mech. Mutagen.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1971\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Molecular heterozygotes in Bacillus subtilis and their correction.\n \n \n \n \n\n\n \n Bresler, S.; Kreneva, R.; and Kushev, V.\n\n\n \n\n\n\n MGG Molecular & General Genetics, 113(3): 204-213. 1971.\n cited By 8\n\n\n\n
\n\n\n\n \n \n $\"Molecular$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler1971204,\r\nauthor={Bresler, S.E. and Kreneva, R.A. and Kushev, V.V.},\r\ntitle={Molecular heterozygotes in Bacillus subtilis and their correction},\r\njournal={MGG Molecular & General Genetics},\r\nyear={1971},\r\nvolume={113},\r\nnumber={3},\r\npages={204-213},\r\ndoi={10.1007/BF00339539},\r\nnote={cited By 8},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0015178420&doi=10.1007%2fBF00339539&partnerID=40&md5=6d51e82542e0f042f8b41c92c1e5f9b8},\r\naffiliation={Physical-Technical Institute of the Academy of Sciences of USSR, Leningrad, Russian Federation},\r\nabstract={Data are presented on the probability of correction of molecular heterozygotes during the transformation of Bacillus subtilis. This value varies between 0 and 1 for different mutants in the same genetic locus. The correction of closely linked markers is simultaneous but it is independent for distant loci. The efficiency of integration of different genetic markers during transformation depends on their ability to be corrected towards the structure of the recipient strain. The linked correction of neighboring markers explains quantitatively the asymmetric phenomena in reciprocal crosses. UV-irradiation of transforming DNA inhibits strongly the correction of molecular heterozygotes and eliminates the asymmetry in reciprocal crosses. The same effect is found after chemical damage of DNA by nitrous acid. © 1971 Springer-Verlag.},\r\ncorrespondence_address1={Bresler, S.E.; Physical-Technical Institute of the Academy of Sciences of USSR, Leningrad, Russian Federation},\r\npublisher={Springer-Verlag},\r\nissn={00268925},\r\ncoden={MGGEA},\r\npubmed_id={5003953},\r\nlanguage={English},\r\nabbrev_source_title={Molec. Gen. Genetics},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1970\n \n \n (3)\n \n \n

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\n \n\n \n \n \n \n \n \n Complete mutagenesis in a bacterial population induced by thymine starvation on solid media.\n \n \n \n \n\n\n \n Bresler, S.; Mosevitsky, M.; and Vyacheslavov, L.\n\n\n \n\n\n\n Nature, 225(5234): 764-766. 1970.\n cited By 22\n\n\n\n
\n\n\n\n \n \n $\"Complete$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler1970764,\r\nauthor={Bresler, S. and Mosevitsky, M. and Vyacheslavov, L.},\r\ntitle={Complete mutagenesis in a bacterial population induced by thymine starvation on solid media},\r\njournal={Nature},\r\nyear={1970},\r\nvolume={225},\r\nnumber={5234},\r\npages={764-766},\r\ndoi={10.1038/225764a0},\r\nnote={cited By 22},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0014957282&doi=10.1038%2f225764a0&partnerID=40&md5=f11d5a29df166fdf987a716fc1c6c366},\r\naffiliation={Institute of High Molecular Weight Compounds, 2d Birjevoy, 6, Leningrad},\r\nabstract={BACTERIA unable to synthesize thymidylic acid (thy-) undergo thymineless death if cultivated in a liquid medium deprived of thymine1,2. We have found, however, that if thy- bacteria are plated on solid nutrient devoid of thymine at a moderate density (not more than 105 cells in a Petri dish) thymineless death does not occur. Cells of Bacillus subtilis remain viable in these conditions for more than 70 h (Fig. 1); cells of Escherichia coli decrease slowly in number: for instance, the cell count of strain B3thy- manifests a drop of 50-60 per cent in the course of 60-70 h. We conclude that the effect is related in some way to the characteristics of growth on a solid surface as distinct from a liquid medium. © 1970 Nature Publishing Group.},\r\ncorrespondence_address1={Bresler, S.; Institute of High Molecular Weight Compounds, 2d Birjevoy, 6, Leningrad},\r\nissn={00280836},\r\npubmed_id={4983895},\r\nlanguage={English},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Electron microscopic autoradiography of recombinant DNA molecules of bacteriophage T1.\n \n \n \n \n\n\n \n Bresler, S.; Dadivanjan, L.; and Mosevitsky, M.\n\n\n \n\n\n\n BBA Section Nucleic Acids And Protein Synthesis, 224(1): 249-252. 1970.\n cited By 3\n\n\n\n
\n\n\n\n \n \n $\"Electron$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler1970249,\r\nauthor={Bresler, S.E. and Dadivanjan, L.P. and Mosevitsky, M.I.},\r\ntitle={Electron microscopic autoradiography of recombinant DNA molecules of bacteriophage T1},\r\njournal={BBA Section Nucleic Acids And Protein Synthesis},\r\nyear={1970},\r\nvolume={224},\r\nnumber={1},\r\npages={249-252},\r\ndoi={10.1016/0005-2787(70)90638-6},\r\nnote={cited By 3},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0014942866&doi=10.1016%2f0005-2787%2870%2990638-6&partnerID=40&md5=13a43966674e540740d66990a175b532},\r\naffiliation={Physical Technical Institute, Academy of Sciences, U.S.S.R., Leningrad, Russian Federation},\r\ncorrespondence_address1={Bresler, S.E.; Physical Technical Institute, Academy of Sciences, U.S.S.R., Leningrad, Russian Federation},\r\nissn={00052787},\r\npubmed_id={5490257},\r\nlanguage={English},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n\n\n\n

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\n \n\n \n \n \n \n \n \n Action or amino acids on the viability of thymine starved Bacillus subtilis cells.\n \n \n \n \n\n\n \n Bresler, S.; Mosevitsky, M.; and Vyacheslavov, L.\n\n\n \n\n\n\n Biochemical and Biophysical Research Communications, 40(1): 243-247. 1970.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"Action$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler1970243,\r\nauthor={Bresler, S.E. and Mosevitsky, M.I. and Vyacheslavov, L.G.},\r\ntitle={Action or amino acids on the viability of thymine starved Bacillus subtilis cells},\r\njournal={Biochemical and Biophysical Research Communications},\r\nyear={1970},\r\nvolume={40},\r\nnumber={1},\r\npages={243-247},\r\ndoi={10.1016/0006-291X(70)91073-9},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0014943863&doi=10.1016%2f0006-291X%2870%2991073-9&partnerID=40&md5=706f73cfaf2455f9a16cab90c9357f9c},\r\naffiliation={Physical Technical Institute, Leningrad, Russian Federation},\r\nabstract={A combination of two amino acids out of the following three: arginine, lysine, Clutamic acid, effects a killing action on thymine starved cells thy- of Bac. subtilis which generally remain viable if plated on a solid medium. This killing effect can be avoided by addition of any of the following amino acids: threonine, valine or leucine. If added together threonine and valine abolish mutually their rescuing action. © 1970.},\r\ncorrespondence_address1={Bresler, S.E.; Physical Technical Institute, Leningrad, Russian Federation},\r\nissn={0006291X},\r\ncoden={BBRCA},\r\npubmed_id={4989679},\r\nlanguage={English},\r\nabbrev_source_title={Biochem. Biophys. Res. Commun.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1968\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Correction of molecular heterozygotes in the course of transformation.\n \n \n \n \n\n\n \n Bresler, S.; Kreneva, R.; and Kushev, V.\n\n\n \n\n\n\n MGG Molecular & General Genetics, 102(3): 257-268. 1968.\n cited By 13\n\n\n\n
\n\n\n\n \n \n $\"Correction$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler1968257,\r\nauthor={Bresler, S.E. and Kreneva, R.A. and Kushev, V.V.},\r\ntitle={Correction of molecular heterozygotes in the course of transformation},\r\njournal={MGG Molecular & General Genetics},\r\nyear={1968},\r\nvolume={102},\r\nnumber={3},\r\npages={257-268},\r\ndoi={10.1007/BF00385983},\r\nnote={cited By 13},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0014383747&doi=10.1007%2fBF00385983&partnerID=40&md5=0b9d37008f54f6a0f13b0348a226359e},\r\naffiliation={Institute of High Molecular Weight Compounds of the Academy of Sciences of U.S.S.R., Leningrad, Russian Federation},\r\nabstract={In the course of this work a method of clonal analysis of transformed cells was developed. This involves growing of cells on nonselective plates, replication of colonies on selective agar to score for recombinants, homogenization of initial colonies and their analysis for pure or mixed progeny. The main result of these experiments is the fact that pure clones are formed with a probability dependent on the specificity of the mutation involved. Proof is given that the pure clones are due to the repair of molecular heterozygotes formed during transformation. Clonal analysis of double transformants gives an approach to the study of independent or simultaneous correction of molecular hets. Experiment shows in case of linked markers that simultaneous repair is overwhelming. When the distance between the markers becomes big enough we find a transition to independent correction of hets. The data are in general agreement with the results of Ephrussi-Taylor on transformation of Pneumococcus. © 1968 Springer-Verlag.},\r\ncorrespondence_address1={Bresler, S.E.; Institute of High Molecular Weight Compounds of the Academy of Sciences of U.S.S.R., Leningrad, Russian Federation},\r\npublisher={Springer-Verlag},\r\nissn={00268925},\r\ncoden={MGGEA},\r\npubmed_id={4974942},\r\nlanguage={English},\r\nabbrev_source_title={Molec. Gen. Genet.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1967\n \n \n (1)\n \n \n

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\n \n\n \n \n \n \n \n \n Isolation and physicochemical investigation of T1 bacteriophage DNA.\n \n \n \n \n\n\n \n Bresler, S.; Kiselev, N.; Manjakov, V.; Mosevitsky, M.; and Timkovsky, A.\n\n\n \n\n\n\n Virology, 33(1): 1-9. 1967.\n cited By 17\n\n\n\n
\n\n\n\n \n \n $\"Isolation$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler19671,\r\nauthor={Bresler, S.E. and Kiselev, N.A. and Manjakov, V.F. and Mosevitsky, M.I. and Timkovsky, A.L.},\r\ntitle={Isolation and physicochemical investigation of T1 bacteriophage DNA},\r\njournal={Virology},\r\nyear={1967},\r\nvolume={33},\r\nnumber={1},\r\npages={1-9},\r\ndoi={10.1016/0042-6822(67)90087-6},\r\nnote={cited By 17},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-0014128314&doi=10.1016%2f0042-6822%2867%2990087-6&partnerID=40&md5=afdd8b57bd44d50de466586709036567},\r\naffiliation={Institute of High Molecular Weight Compounds, the Academy of Sciences, USSR, Leningrad, Russian Federation; Institute of Crystallography, the Academy of Sciences, USSR, Moscow, Russian Federation},\r\nabstract={After isolation under mild conditions, T1 phage DNA preserves its connection with the phage coat. The bond can be cleaved by increased temperature, high pH, high ionic strength, and phenol treatment, but it is stable at low pH and during ethanol precipitation. T1 phage DNA has a sedimentation coefficient S0 20,W = 33.5 S, a molecular weight M = 31-32 × 106 daltons, and an intrinsic viscosity [η] = 120 dl/g. Not less than 50% of the polynucleotide chains of T1 phage DNA are free of preformed breaks. © 1967.},\r\ncorrespondence_address1={Bresler, S.E.; Institute of High Molecular Weight Compounds, the Academy of Sciences, USSR, Leningrad, Russian Federation},\r\nissn={00426822},\r\ncoden={VIRLA},\r\npubmed_id={6039960},\r\nlanguage={English},\r\nabbrev_source_title={Virology},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n 1964\n \n \n (4)\n \n \n

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\n \n\n \n \n \n \n \n \n ON THE PARTICIPATION OF BOTH STRANDS OF DNA IN THE TRANSFER OF GENETIC [OB UCHASTII OBEIKH TSEPE I MOLEKULY DNK V PERENOSE GENETICHESKO I].\n \n \n \n \n\n\n \n BRESLER, S.; KRENEVA, R.; KUSHEV, V.; and MOSEVITSKII, M.\n\n\n \n\n\n\n Biokhimiia (Moscow, Russia), 29: 477-486. 1964.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"ON$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{BRESLER1964477,\r\nauthor={BRESLER, S.E. and KRENEVA, R.A. and KUSHEV, V.V. and MOSEVITSKII, M.I.},\r\ntitle={ON THE PARTICIPATION OF BOTH STRANDS OF DNA IN THE TRANSFER OF GENETIC [OB UCHASTII OBEIKH TSEPE I MOLEKULY DNK V PERENOSE GENETICHESKO I]},\r\njournal={Biokhimiia (Moscow, Russia)},\r\nyear={1964},\r\nvolume={29},\r\npages={477-486},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-78651199586&partnerID=40&md5=fe22f357b7bc8683a0be6714a91bf5c0},\r\ncorrespondence_address1={BRESLER, S.E.},\r\nissn={03209725},\r\npubmed_id={14221748},\r\nlanguage={Russian},\r\nabbrev_source_title={Biokhimiia},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n MOLECULAR MECHANISM OF GENETIC RECOMBINATION IN BACTERIAL TRANSFORMATION. [MOLEKULIARNY I MEKHANIZM GENETICHESKO I REKOMBINATSII PRI TRANSFORMATSII BAKTERI I.].\n \n \n \n \n\n\n \n BRESLER, S.; KRENEVA, R.; KUSHEV, V.; and MOSEVITSKII, M.\n\n\n \n\n\n\n Biokhimiia (Moscow, Russia), 29: 1103-1110. 1964.\n cited By 0\n\n\n\n
\n\n\n\n \n \n $\"MOLECULAR$ Paper\n \n \n\n \n\n \n link\n \n \n\n bibtex\n \n\n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{BRESLER19641103,\r\nauthor={BRESLER, S.E. and KRENEVA, R.A. and KUSHEV, V.V. and MOSEVITSKII, M.I.},\r\ntitle={MOLECULAR MECHANISM OF GENETIC RECOMBINATION IN BACTERIAL TRANSFORMATION. [MOLEKULIARNY I MEKHANIZM GENETICHESKO I REKOMBINATSII PRI TRANSFORMATSII BAKTERI I.]},\r\njournal={Biokhimiia (Moscow, Russia)},\r\nyear={1964},\r\nvolume={29},\r\npages={1103-1110},\r\nnote={cited By 0},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-76549170286&partnerID=40&md5=14c6a0d7ad4a2d79bad1726e71d338c9},\r\ncorrespondence_address1={BRESLER, S.E.},\r\nissn={03209725},\r\npubmed_id={14320819},\r\nlanguage={Russian},\r\nabbrev_source_title={Biokhimiia},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n Molecular mechanism of genetic recombination in bacterial transformation.\n \n \n \n \n\n\n \n Bresler, S.; Kreneva, R.; Kushev, V.; and Mosevitskií, M.\n\n\n \n\n\n\n Zeitschrift für Vererbungslehre, 95(3): 288-297. 1964.\n cited By 8\n\n\n\n
\n\n\n\n \n \n $\"Molecular$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler1964288,\r\nauthor={Bresler, S.E. and Kreneva, R.A. and Kushev, V.V. and Mosevitskií, M.I.},\r\ntitle={Molecular mechanism of genetic recombination in bacterial transformation},\r\njournal={Zeitschrift für Vererbungslehre},\r\nyear={1964},\r\nvolume={95},\r\nnumber={3},\r\npages={288-297},\r\ndoi={10.1007/BF00897013},\r\nnote={cited By 8},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-13344274558&doi=10.1007%2fBF00897013&partnerID=40&md5=677aa1725797318eb1550cd0ff40b995},\r\naffiliation={Institute of High Molecular Weight Compounds of the Academy of Sciences of U.S.S.R., Lenmgrad, Russia},\r\nabstract={B. subtilis cells auxotrophic for two linked markers (ind-his, ind-tyr, his-tyr) have been transformed by means of DNA preparations obtained by hybridization of wild type DNA with the DNA of a strain auxotrophic for one of the linked markers. It was established that hybridization does not increase the transforming activity of DNA for the heterozygous marker. A genetic analysis of the progeny of cells transformed by hybrid or wild type DNA was performed. On the basis of the data obtained a model of genetic recombination in transformation is proved. According to this model both strands of the donor DNA interact independently with the chromosome, and either strand can be incorporated into the cell genome with equal probability. According to the estimate made on the basis of this hypothesis, the probability of integration of a single DNA strand carrying a particular genetic marker is 8%. © 1964 Springer-Verlag.},\r\ncorrespondence_address1={Bresler, S.E.; Institute of High Molecular Weight Compounds of the Academy of Sciences of U.S.S.R., Lenmgrad, Russia},\r\npublisher={Springer-Verlag},\r\nissn={16174615},\r\ncoden={MGGOA},\r\npubmed_id={14339939},\r\nlanguage={English},\r\nabbrev_source_title={Mol. Genet. Genomics},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n\r\n

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\n \n\n \n \n \n \n \n \n The mechanism of messenger-RNA replication in bacteria.\n \n \n \n \n\n\n \n Bresler, S.; Kreneva, R.; Kushev, V.; and Mosevitskií, M.\n\n\n \n\n\n\n Journal of Molecular Biology, 8(1): 79-88. 1964.\n cited By 1\n\n\n\n
\n\n\n\n \n \n $\"The$ Paper\n \n \n\n \n \n doi\n \n \n\n \n link\n \n \n\n bibtex\n \n\n \n \n \n abstract \n \n\n \n\n \n \n \n \n \n \n \n\n \n \n \n\n\n\n

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@ARTICLE{Bresler196479,\r\nauthor={Bresler, S.E. and Kreneva, R.A. and Kushev, V.V. and Mosevitskií, M.I.},\r\ntitle={The mechanism of messenger-RNA replication in bacteria},\r\njournal={Journal of Molecular Biology},\r\nyear={1964},\r\nvolume={8},\r\nnumber={1},\r\npages={79-88},\r\ndoi={10.1016/S0022-2836(64)80150-9},\r\nnote={cited By 1},\r\nurl={https://www.scopus.com/inward/record.uri?eid=2-s2.0-78651163202&doi=10.1016%2fS0022-2836%2864%2980150-9&partnerID=40&md5=2119b6218b51758464d8808249d27e59},\r\naffiliation={Institute of High Molecular Weight Compounds, Academy of Sciences of U.S.S.R., Leningrad},\r\nabstract={The role of both strands of the DNA double helix in the process of information transfer for protein synthesis in the living cell was investigated. For this purpose the transformation of Bacillus subtilis SB 25 his− tryp− by two linked genetic markers under the action of hybrid molecules of DNA was used. The molecular hybrids were obtained by thermal denaturation and annealing of a mixture of two DNAs, each one extracted from a single auxotrophic strain (H25 his− and 168 tryp−). The formation of the heterozygous DNA double helices was proved by special experiments. The transformation procedure excluded DNA synthesis by recipient cells prior to the formation of enzymes for histidine and tryptophan synthesis. It was found that hybrid DNA molecules are able to transform in these conditions the double auxotrophic cells to prototrophic ones. Therefore we must assume that both strands of the DNA double helix can serve as templates for messenger-RNA synthesis. © 1964, Academic Press Inc. (London) Ltd.. All rights reserved.},\r\nauthor_keywords={M-RNA;  messenger RNA;  salt-glucose medium (see Materials and Methods);  SGM},\r\ncorrespondence_address1={Bresler, S.E.; Institute of High Molecular Weight Compounds, Academy of Sciences of U.S.S.R., Leningrad},\r\nissn={00222836},\r\npubmed_id={14149965},\r\nlanguage={English},\r\nabbrev_source_title={J. Mol. Biol.},\r\ndocument_type={Article},\r\nsource={Scopus},\r\n}\r\n

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