Inappropriate anticholinergic drugs prescriptions in older patients: analysing a hospital database. Ferret, L., Ficheur, G., Delaviez, E., Luyckx, M., Quenton, S., Beuscart, R., Chazard, E., & Beuscart, J. International Journal of Clinical Pharmacy, November, 2017. ![Inappropriate anticholinergic drugs prescriptions in older patients: analysing a hospital database [link]](https://bibbase.org/img/filetypes/link.svg "link")
Paper doi abstract bibtex Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009–2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia. Cases of constipation that might have been causally related to the administration of anticholinergic drugs were screened for and reviewed. Main outcome measure Prescriptions with a high associated risk of anticholinergic related adverse reactions. Results Administration of an anticholinergic drug was detected in 1412 (10.0%) of the hospital stays by older patients. At-risk situations were identified in 413 (36.5%) of these stays: 137 (9.7%) for falls, 243 (17.2%) for dementia, and 114 (8.1%) for benign prostatic hyperplasia; 78 (18.9%) of these 413 stays featured a combination of two or three at-risk situations. Cases of constipation induced by anticholinergic drug administration were identified in 188 (13.3%) patient stays by using validated adjudication rules for adverse drug reactions: 85 and 103 cases were respectively evaluated as “possible” or “probable” adverse drug reactions. Conclusions Anticholinergic drugs prescription was found in 10.0% of hospitalized, older patients. More than one third of these prescriptions occurred in at-risk situations and more than one in ten prescriptions induced constipation.
@article{ferret_inappropriate_2017,
title = {Inappropriate anticholinergic drugs prescriptions in older patients: analysing a hospital database},
copyright = {All rights reserved},
issn = {2210-7703, 2210-7711},
shorttitle = {Inappropriate anticholinergic drugs prescriptions in older patients},
url = {https://link.springer.com/article/10.1007/s11096-017-0554-z},
doi = {10.1007/s11096-017-0554-z},
abstract = {Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009–2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia. Cases of constipation that might have been causally related to the administration of anticholinergic drugs were screened for and reviewed. Main outcome measure Prescriptions with a high associated risk of anticholinergic related adverse reactions. Results Administration of an anticholinergic drug was detected in 1412 (10.0\%) of the hospital stays by older patients. At-risk situations were identified in 413 (36.5\%) of these stays: 137 (9.7\%) for falls, 243 (17.2\%) for dementia, and 114 (8.1\%) for benign prostatic hyperplasia; 78 (18.9\%) of these 413 stays featured a combination of two or three at-risk situations. Cases of constipation induced by anticholinergic drug administration were identified in 188 (13.3\%) patient stays by using validated adjudication rules for adverse drug reactions: 85 and 103 cases were respectively evaluated as “possible” or “probable” adverse drug reactions. Conclusions Anticholinergic drugs prescription was found in 10.0\% of hospitalized, older patients. More than one third of these prescriptions occurred in at-risk situations and more than one in ten prescriptions induced constipation.},
language = {en},
urldate = {2017-11-17},
journal = {International Journal of Clinical Pharmacy},
author = {Ferret, Laurie and Ficheur, Gregoire and Delaviez, Emeline and Luyckx, Michel and Quenton, Sophie and Beuscart, Regis and Chazard, Emmanuel and Beuscart, Jean-Baptiste},
month = nov,
year = {2017},
pages = {1--7},
}
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Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009–2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia. Cases of constipation that might have been causally related to the administration of anticholinergic drugs were screened for and reviewed. Main outcome measure Prescriptions with a high associated risk of anticholinergic related adverse reactions. Results Administration of an anticholinergic drug was detected in 1412 (10.0%) of the hospital stays by older patients. At-risk situations were identified in 413 (36.5%) of these stays: 137 (9.7%) for falls, 243 (17.2%) for dementia, and 114 (8.1%) for benign prostatic hyperplasia; 78 (18.9%) of these 413 stays featured a combination of two or three at-risk situations. Cases of constipation induced by anticholinergic drug administration were identified in 188 (13.3%) patient stays by using validated adjudication rules for adverse drug reactions: 85 and 103 cases were respectively evaluated as “possible” or “probable” adverse drug reactions. Conclusions Anticholinergic drugs prescription was found in 10.0% of hospitalized, older patients. More than one third of these prescriptions occurred in at-risk situations and more than one in ten prescriptions induced constipation.","language":"en","urldate":"2017-11-17","journal":"International Journal of Clinical Pharmacy","author":[{"propositions":[],"lastnames":["Ferret"],"firstnames":["Laurie"],"suffixes":[]},{"propositions":[],"lastnames":["Ficheur"],"firstnames":["Gregoire"],"suffixes":[]},{"propositions":[],"lastnames":["Delaviez"],"firstnames":["Emeline"],"suffixes":[]},{"propositions":[],"lastnames":["Luyckx"],"firstnames":["Michel"],"suffixes":[]},{"propositions":[],"lastnames":["Quenton"],"firstnames":["Sophie"],"suffixes":[]},{"propositions":[],"lastnames":["Beuscart"],"firstnames":["Regis"],"suffixes":[]},{"propositions":[],"lastnames":["Chazard"],"firstnames":["Emmanuel"],"suffixes":[]},{"propositions":[],"lastnames":["Beuscart"],"firstnames":["Jean-Baptiste"],"suffixes":[]}],"month":"November","year":"2017","pages":"1–7","bibtex":"@article{ferret_inappropriate_2017,\n\ttitle = {Inappropriate anticholinergic drugs prescriptions in older patients: analysing a hospital database},\n\tcopyright = {All rights reserved},\n\tissn = {2210-7703, 2210-7711},\n\tshorttitle = {Inappropriate anticholinergic drugs prescriptions in older patients},\n\turl = {https://link.springer.com/article/10.1007/s11096-017-0554-z},\n\tdoi = {10.1007/s11096-017-0554-z},\n\tabstract = {Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009–2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia. Cases of constipation that might have been causally related to the administration of anticholinergic drugs were screened for and reviewed. Main outcome measure Prescriptions with a high associated risk of anticholinergic related adverse reactions. Results Administration of an anticholinergic drug was detected in 1412 (10.0\\%) of the hospital stays by older patients. At-risk situations were identified in 413 (36.5\\%) of these stays: 137 (9.7\\%) for falls, 243 (17.2\\%) for dementia, and 114 (8.1\\%) for benign prostatic hyperplasia; 78 (18.9\\%) of these 413 stays featured a combination of two or three at-risk situations. Cases of constipation induced by anticholinergic drug administration were identified in 188 (13.3\\%) patient stays by using validated adjudication rules for adverse drug reactions: 85 and 103 cases were respectively evaluated as “possible” or “probable” adverse drug reactions. Conclusions Anticholinergic drugs prescription was found in 10.0\\% of hospitalized, older patients. More than one third of these prescriptions occurred in at-risk situations and more than one in ten prescriptions induced constipation.},\n\tlanguage = {en},\n\turldate = {2017-11-17},\n\tjournal = {International Journal of Clinical Pharmacy},\n\tauthor = {Ferret, Laurie and Ficheur, Gregoire and Delaviez, Emeline and Luyckx, Michel and Quenton, Sophie and Beuscart, Regis and Chazard, Emmanuel and Beuscart, Jean-Baptiste},\n\tmonth = nov,\n\tyear = {2017},\n\tpages = {1--7},\n}\n\n","author_short":["Ferret, L.","Ficheur, G.","Delaviez, E.","Luyckx, M.","Quenton, S.","Beuscart, R.","Chazard, E.","Beuscart, J."],"key":"ferret_inappropriate_2017","id":"ferret_inappropriate_2017","bibbaseid":"ferret-ficheur-delaviez-luyckx-quenton-beuscart-chazard-beuscart-inappropriateanticholinergicdrugsprescriptionsinolderpatientsanalysingahospitaldatabase-2017","role":"author","urls":{"Paper":"https://link.springer.com/article/10.1007/s11096-017-0554-z"},"metadata":{"authorlinks":{"chazard, e":"https://www.chazard.org/emmanuel/publications_older.htm"}},"downloads":0},"search_terms":["inappropriate","anticholinergic","drugs","prescriptions","older","patients","analysing","hospital","database","ferret","ficheur","delaviez","luyckx","quenton","beuscart","chazard","beuscart"],"keywords":[],"authorIDs":["56bbc1d374cc1b530f000455","5de7e5e0c8f9f6df0100015e","5de7f8ccc8f9f6df010002bb","5ded28f59d5885de01000036","5def9dac706001de010000cd","5dfdca63b6b936e401000059","5e343c4b0c807ede01000031","5e5145c6fe5af9df0100007a","TaHudmME8852eigtD","dbGudjxzAqNqqb9kP","kBW6Tt8nkHnKvzNQj","sNmKyQYr9ZbXTXPBe"],"dataSources":["Ad3P6FkzWSCKrZQXc"]}