Inappropriate anticholinergic drugs prescriptions in older patients: analysing a hospital database. Ferret, L., Ficheur, G., Delaviez, E., Luyckx, M., Quenton, S., Beuscart, R., Chazard, E., & Beuscart, J. International Journal of Clinical Pharmacy, November, 2017.
Inappropriate anticholinergic drugs prescriptions in older patients: analysing a hospital database [link]Paper  doi  abstract   bibtex   
Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009–2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia. Cases of constipation that might have been causally related to the administration of anticholinergic drugs were screened for and reviewed. Main outcome measure Prescriptions with a high associated risk of anticholinergic related adverse reactions. Results Administration of an anticholinergic drug was detected in 1412 (10.0%) of the hospital stays by older patients. At-risk situations were identified in 413 (36.5%) of these stays: 137 (9.7%) for falls, 243 (17.2%) for dementia, and 114 (8.1%) for benign prostatic hyperplasia; 78 (18.9%) of these 413 stays featured a combination of two or three at-risk situations. Cases of constipation induced by anticholinergic drug administration were identified in 188 (13.3%) patient stays by using validated adjudication rules for adverse drug reactions: 85 and 103 cases were respectively evaluated as “possible” or “probable” adverse drug reactions. Conclusions Anticholinergic drugs prescription was found in 10.0% of hospitalized, older patients. More than one third of these prescriptions occurred in at-risk situations and more than one in ten prescriptions induced constipation.
@article{ferret_inappropriate_2017,
	title = {Inappropriate anticholinergic drugs prescriptions in older patients: analysing a hospital database},
	copyright = {All rights reserved},
	issn = {2210-7703, 2210-7711},
	shorttitle = {Inappropriate anticholinergic drugs prescriptions in older patients},
	url = {https://link.springer.com/article/10.1007/s11096-017-0554-z},
	doi = {10.1007/s11096-017-0554-z},
	abstract = {Background Although many anticholinergics are inappropriate in older patients, the prescription of these drugs in a hospital setting has not been extensively studied. Objective To describe prescriptions of anticholinergic drugs in terms of frequency, at risk situations and constipation in hospitalized, older adults. Setting Using a database from a French general hospital (period 2009–2013), we extracted information on 14,090 hospital stays by patients aged 75 and over. Methods Anticholinergic drug prescriptions were automatically detected, with a focus on prescriptions in three well-known at-risk situations: falls, dementia, and benign prostatic hyperplasia. Cases of constipation that might have been causally related to the administration of anticholinergic drugs were screened for and reviewed. Main outcome measure Prescriptions with a high associated risk of anticholinergic related adverse reactions. Results Administration of an anticholinergic drug was detected in 1412 (10.0\%) of the hospital stays by older patients. At-risk situations were identified in 413 (36.5\%) of these stays: 137 (9.7\%) for falls, 243 (17.2\%) for dementia, and 114 (8.1\%) for benign prostatic hyperplasia; 78 (18.9\%) of these 413 stays featured a combination of two or three at-risk situations. Cases of constipation induced by anticholinergic drug administration were identified in 188 (13.3\%) patient stays by using validated adjudication rules for adverse drug reactions: 85 and 103 cases were respectively evaluated as “possible” or “probable” adverse drug reactions. Conclusions Anticholinergic drugs prescription was found in 10.0\% of hospitalized, older patients. More than one third of these prescriptions occurred in at-risk situations and more than one in ten prescriptions induced constipation.},
	language = {en},
	urldate = {2017-11-17},
	journal = {International Journal of Clinical Pharmacy},
	author = {Ferret, Laurie and Ficheur, Gregoire and Delaviez, Emeline and Luyckx, Michel and Quenton, Sophie and Beuscart, Regis and Chazard, Emmanuel and Beuscart, Jean-Baptiste},
	month = nov,
	year = {2017},
	pages = {1--7}
}

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