@article{magnusson_genetic_2022,
	title = {The genetic contribution to hand osteoarthritis},
	issn = {1063-4584},
	url = {https://www.sciencedirect.com/science/article/pii/S1063458422007750},
	doi = {10.1016/j.joca.2022.06.011},
	abstract = {Objective
To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods
Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk.
Results
Among 59,970 included persons, 936 had a hand OA diagnosis registered during the study period. The heritabilities of hand OA (any joint), CMC-1 OA and DIP/PIP OA were ∼87\%, 86\% and 48\%, respectively, yet the two latter should be interpreted with care due to low numbers. Hand OA in any joint in both twins in a pair occurred more frequently in identical twins (54/554 = 9.7\%, intra-pair correlation = 0.54, 95\% CI = 0.44–0.63) than in fraternal twins (18/1,246 = 1.4\%, intra-pair correlation = 0.10, 95\% CI = −0.01–0.22). Identical twins who were diagnosed with hand OA in any joint had a far higher risk than fraternal twins with hand OA to also have their co-twin diagnosed with hand OA in any joint (Hazard Ratio = 6.98, 95\% CI = 3.08–15.45).
Conclusion
The genetic contribution to hand OA is high and likely varying between 48\% and 87\%. Potential differential heritability by hand OA phenotypes should be further explored.},
	language = {en},
	urldate = {2022-08-26},
	journal = {Osteoarthritis and Cartilage},
	author = {Magnusson, K. and Turkiewicz, A. and Haugen, I. K. and Englund, M.},
	month = jul,
	year = {2022},
	keywords = {Epidemiology, Genetics, Hand OA},
}

{"_id":"CNEEDEK4ko2dKb9u7","bibbaseid":"magnusson-turkiewicz-haugen-englund-thegeneticcontributiontohandosteoarthritis-2022","author_short":["Magnusson, K.","Turkiewicz, A.","Haugen, I. K.","Englund, M."],"bibdata":{"bibtype":"article","type":"article","title":"The genetic contribution to hand osteoarthritis","issn":"1063-4584","url":"https://www.sciencedirect.com/science/article/pii/S1063458422007750","doi":"10.1016/j.joca.2022.06.011","abstract":"Objective To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk. Results Among 59,970 included persons, 936 had a hand OA diagnosis registered during the study period. The heritabilities of hand OA (any joint), CMC-1 OA and DIP/PIP OA were ∼87%, 86% and 48%, respectively, yet the two latter should be interpreted with care due to low numbers. Hand OA in any joint in both twins in a pair occurred more frequently in identical twins (54/554 = 9.7%, intra-pair correlation = 0.54, 95% CI = 0.44–0.63) than in fraternal twins (18/1,246 = 1.4%, intra-pair correlation = 0.10, 95% CI = −0.01–0.22). Identical twins who were diagnosed with hand OA in any joint had a far higher risk than fraternal twins with hand OA to also have their co-twin diagnosed with hand OA in any joint (Hazard Ratio = 6.98, 95% CI = 3.08–15.45). Conclusion The genetic contribution to hand OA is high and likely varying between 48% and 87%. Potential differential heritability by hand OA phenotypes should be further explored.","language":"en","urldate":"2022-08-26","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Magnusson"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Turkiewicz"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Haugen"],"firstnames":["I.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["M."],"suffixes":[]}],"month":"July","year":"2022","keywords":"Epidemiology, Genetics, Hand OA","bibtex":"@article{magnusson_genetic_2022,\n\ttitle = {The genetic contribution to hand osteoarthritis},\n\tissn = {1063-4584},\n\turl = {https://www.sciencedirect.com/science/article/pii/S1063458422007750},\n\tdoi = {10.1016/j.joca.2022.06.011},\n\tabstract = {Objective\nTo estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). Methods\nUsing data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk.\nResults\nAmong 59,970 included persons, 936 had a hand OA diagnosis registered during the study period. The heritabilities of hand OA (any joint), CMC-1 OA and DIP/PIP OA were ∼87\\%, 86\\% and 48\\%, respectively, yet the two latter should be interpreted with care due to low numbers. Hand OA in any joint in both twins in a pair occurred more frequently in identical twins (54/554 = 9.7\\%, intra-pair correlation = 0.54, 95\\% CI = 0.44–0.63) than in fraternal twins (18/1,246 = 1.4\\%, intra-pair correlation = 0.10, 95\\% CI = −0.01–0.22). Identical twins who were diagnosed with hand OA in any joint had a far higher risk than fraternal twins with hand OA to also have their co-twin diagnosed with hand OA in any joint (Hazard Ratio = 6.98, 95\\% CI = 3.08–15.45).\nConclusion\nThe genetic contribution to hand OA is high and likely varying between 48\\% and 87\\%. Potential differential heritability by hand OA phenotypes should be further explored.},\n\tlanguage = {en},\n\turldate = {2022-08-26},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Magnusson, K. and Turkiewicz, A. and Haugen, I. K. and Englund, M.},\n\tmonth = jul,\n\tyear = {2022},\n\tkeywords = {Epidemiology, Genetics, Hand OA},\n}\n\n","author_short":["Magnusson, K.","Turkiewicz, A.","Haugen, I. K.","Englund, M."],"key":"magnusson_genetic_2022","id":"magnusson_genetic_2022","bibbaseid":"magnusson-turkiewicz-haugen-englund-thegeneticcontributiontohandosteoarthritis-2022","role":"author","urls":{"Paper":"https://www.sciencedirect.com/science/article/pii/S1063458422007750"},"keyword":["Epidemiology","Genetics","Hand OA"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5155143/items?key=IVTAjWy1U5EkGJqE2Z2qQCfh&format=bibtex&limit=100","dataSources":["7PYyrRz6AvkoBBchz","NGDbv8dMYDaDn8kqm","5jEuhQhgRx3py8LmG","LPTeGao77ndnG4Tks"],"keywords":["epidemiology","genetics","hand oa"],"search_terms":["genetic","contribution","hand","osteoarthritis","magnusson","turkiewicz","haugen","englund"],"title":"The genetic contribution to hand osteoarthritis","year":2022}