@article{magnusson_genetic_2022,
	title = {The genetic contribution to hand osteoarthritis},
	volume = {30},
	issn = {1522-9653},
	doi = {10.1016/j.joca.2022.06.011},
	abstract = {OBJECTIVE: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA).
METHODS: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk.
RESULTS: Among 59,970 included persons, 936 had a hand OA diagnosis registered during the study period. The heritabilities of hand OA (any joint), CMC-1 OA and DIP/PIP OA were ∼87\%, 86\% and 48\%, respectively, yet the two latter should be interpreted with care due to low numbers. Hand OA in any joint in both twins in a pair occurred more frequently in identical twins (54/554 = 9.7\%, intra-pair correlation = 0.54, 95\% CI = 0.44-0.63) than in fraternal twins (18/1,246 = 1.4\%, intra-pair correlation = 0.10, 95\% CI = -0.01-0.22). Identical twins who were diagnosed with hand OA in any joint had a far higher risk than fraternal twins with hand OA to also have their co-twin diagnosed with hand OA in any joint (Hazard Ratio = 6.98, 95\% CI = 3.08-15.45).
CONCLUSION: The genetic contribution to hand OA is high and likely varying between 48\% and 87\%. Potential differential heritability by hand OA phenotypes should be further explored.},
	language = {eng},
	number = {10},
	journal = {Osteoarthritis and Cartilage},
	author = {Magnusson, K. and Turkiewicz, A. and Haugen, I. K. and Englund, M.},
	month = oct,
	year = {2022},
	pmid = {35843480},
	keywords = {Carpometacarpal Joints, Epidemiology, Genetics, Hand, Hand OA, Humans, Longitudinal Studies, Osteoarthritis, Twins, Dizygotic, Twins, Monozygotic},
	pages = {1385--1389},
}

{"_id":"CNEEDEK4ko2dKb9u7","bibbaseid":"magnusson-turkiewicz-haugen-englund-thegeneticcontributiontohandosteoarthritis-2022","author_short":["Magnusson, K.","Turkiewicz, A.","Haugen, I. K.","Englund, M."],"bibdata":{"bibtype":"article","type":"article","title":"The genetic contribution to hand osteoarthritis","volume":"30","issn":"1522-9653","doi":"10.1016/j.joca.2022.06.011","abstract":"OBJECTIVE: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA). METHODS: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk. RESULTS: Among 59,970 included persons, 936 had a hand OA diagnosis registered during the study period. The heritabilities of hand OA (any joint), CMC-1 OA and DIP/PIP OA were ∼87%, 86% and 48%, respectively, yet the two latter should be interpreted with care due to low numbers. Hand OA in any joint in both twins in a pair occurred more frequently in identical twins (54/554 = 9.7%, intra-pair correlation = 0.54, 95% CI = 0.44-0.63) than in fraternal twins (18/1,246 = 1.4%, intra-pair correlation = 0.10, 95% CI = -0.01-0.22). Identical twins who were diagnosed with hand OA in any joint had a far higher risk than fraternal twins with hand OA to also have their co-twin diagnosed with hand OA in any joint (Hazard Ratio = 6.98, 95% CI = 3.08-15.45). CONCLUSION: The genetic contribution to hand OA is high and likely varying between 48% and 87%. Potential differential heritability by hand OA phenotypes should be further explored.","language":"eng","number":"10","journal":"Osteoarthritis and Cartilage","author":[{"propositions":[],"lastnames":["Magnusson"],"firstnames":["K."],"suffixes":[]},{"propositions":[],"lastnames":["Turkiewicz"],"firstnames":["A."],"suffixes":[]},{"propositions":[],"lastnames":["Haugen"],"firstnames":["I.","K."],"suffixes":[]},{"propositions":[],"lastnames":["Englund"],"firstnames":["M."],"suffixes":[]}],"month":"October","year":"2022","pmid":"35843480","keywords":"Carpometacarpal Joints, Epidemiology, Genetics, Hand, Hand OA, Humans, Longitudinal Studies, Osteoarthritis, Twins, Dizygotic, Twins, Monozygotic","pages":"1385–1389","bibtex":"@article{magnusson_genetic_2022,\n\ttitle = {The genetic contribution to hand osteoarthritis},\n\tvolume = {30},\n\tissn = {1522-9653},\n\tdoi = {10.1016/j.joca.2022.06.011},\n\tabstract = {OBJECTIVE: To estimate the genetic contribution to doctor-diagnosed hand osteoarthritis (OA).\nMETHODS: Using data from the Swedish Twin Registry and National Patient Register, we conducted a 20-year population-based longitudinal cohort study including 59,970 twins aged 35 years or older. We studied inpatient and outpatient doctor-diagnosed hand OA using ICD-10 codes from 1997 until 2016, including both the distal/proximal interphalangeal (DIP/PIP) joints and/or the first carpometacarpal (CMC-1) joints. We calculated intra-pair correlation, estimated the heritability (i.e., the percentage variation in hand OA that can be explained by genetic factors) as well as a genetic risk.\nRESULTS: Among 59,970 included persons, 936 had a hand OA diagnosis registered during the study period. The heritabilities of hand OA (any joint), CMC-1 OA and DIP/PIP OA were ∼87\\%, 86\\% and 48\\%, respectively, yet the two latter should be interpreted with care due to low numbers. Hand OA in any joint in both twins in a pair occurred more frequently in identical twins (54/554 = 9.7\\%, intra-pair correlation = 0.54, 95\\% CI = 0.44-0.63) than in fraternal twins (18/1,246 = 1.4\\%, intra-pair correlation = 0.10, 95\\% CI = -0.01-0.22). Identical twins who were diagnosed with hand OA in any joint had a far higher risk than fraternal twins with hand OA to also have their co-twin diagnosed with hand OA in any joint (Hazard Ratio = 6.98, 95\\% CI = 3.08-15.45).\nCONCLUSION: The genetic contribution to hand OA is high and likely varying between 48\\% and 87\\%. Potential differential heritability by hand OA phenotypes should be further explored.},\n\tlanguage = {eng},\n\tnumber = {10},\n\tjournal = {Osteoarthritis and Cartilage},\n\tauthor = {Magnusson, K. and Turkiewicz, A. and Haugen, I. K. and Englund, M.},\n\tmonth = oct,\n\tyear = {2022},\n\tpmid = {35843480},\n\tkeywords = {Carpometacarpal Joints, Epidemiology, Genetics, Hand, Hand OA, Humans, Longitudinal Studies, Osteoarthritis, Twins, Dizygotic, Twins, Monozygotic},\n\tpages = {1385--1389},\n}\n\n","author_short":["Magnusson, K.","Turkiewicz, A.","Haugen, I. K.","Englund, M."],"key":"magnusson_genetic_2022","id":"magnusson_genetic_2022","bibbaseid":"magnusson-turkiewicz-haugen-englund-thegeneticcontributiontohandosteoarthritis-2022","role":"author","urls":{},"keyword":["Carpometacarpal Joints","Epidemiology","Genetics","Hand","Hand OA","Humans","Longitudinal Studies","Osteoarthritis","Twins","Dizygotic","Twins","Monozygotic"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://api.zotero.org/groups/5155143/items?key=IVTAjWy1U5EkGJqE2Z2qQCfh&format=bibtex&limit=100","dataSources":["7PYyrRz6AvkoBBchz","NGDbv8dMYDaDn8kqm","5jEuhQhgRx3py8LmG","LPTeGao77ndnG4Tks"],"keywords":["carpometacarpal joints","epidemiology","genetics","hand","hand oa","humans","longitudinal studies","osteoarthritis","twins","dizygotic","twins","monozygotic"],"search_terms":["genetic","contribution","hand","osteoarthritis","magnusson","turkiewicz","haugen","englund"],"title":"The genetic contribution to hand osteoarthritis","year":2022}