@article{HANSEN2021114244,
title = {Unsupervised supervoxel-based lung tumor segmentation across patient scans in hybrid PET/MRI},
journal = {Expert Systems with Applications},
volume = {167},
pages = {114244},
year = {2021},
issn = {0957-4174},
doi = {10.1016/j.eswa.2020.114244},
url = {https://www.sciencedirect.com/science/article/pii/S0957417420309623},
author = {Stine Hansen and Samuel Kuttner and Michael Kampffmeyer and Tom-Vegard Markussen and Rune Sundset and Silje Kjærnes Øen and Live Eikenes and Robert Jenssen},
keywords = {Clustering, Unsupervised learning, Medical image segmentation, Tumor segmentation, Hybrid PET/MRI},
abstract = {Tumor segmentation is a crucial but difficult task in treatment planning and follow-up of cancerous patients. The challenge of automating the tumor segmentation has recently received a lot of attention, but the potential of utilizing hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI), a novel and promising imaging modality in oncology, is still under-explored. Recent approaches have either relied on manual user input and/or performed the segmentation patient-by-patient, whereas a fully unsupervised segmentation framework that exploits the available information from all patients is still lacking. We present an unsupervised across-patients supervoxel-based clustering framework for lung tumor segmentation in hybrid PET/MRI. The method consists of two steps: First, each patient is represented by a set of PET/MRI supervoxel-features. Then the data points from all patients are transformed and clustered on a population level into tumor and non-tumor supervoxels. The proposed framework is tested on the scans of 18 non-small cell lung cancer patients with a total of 19 tumors and evaluated with respect to manual delineations provided by clinicians. Experiments study the performance of several commonly used clustering algorithms within the framework and provide analysis of (i) the effect of tumor size, (ii) the segmentation errors, (iii) the benefit of across-patient clustering, and (iv) the noise robustness. The proposed framework detected 15 out of 19 tumors in an unsupervised manner. Moreover, performance increased considerably by segmenting across patients, with the mean dice score increasing from 0.169±0.295 (patient-by-patient) to 0.470±0.308 (across-patients). Results demonstrate that both spectral clustering and Manhattan hierarchical clustering have the potential to segment tumors in PET/MRI with a low number of missed tumors and a low number of false-positives, but that spectral clustering seems to be more robust to noise.}
}

Tumor segmentation is a crucial but difficult task in treatment planning and follow-up of cancerous patients. The challenge of automating the tumor segmentation has recently received a lot of attention, but the potential of utilizing hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI), a novel and promising imaging modality in oncology, is still under-explored. Recent approaches have either relied on manual user input and/or performed the segmentation patient-by-patient, whereas a fully unsupervised segmentation framework that exploits the available information from all patients is still lacking. We present an unsupervised across-patients supervoxel-based clustering framework for lung tumor segmentation in hybrid PET/MRI. The method consists of two steps: First, each patient is represented by a set of PET/MRI supervoxel-features. Then the data points from all patients are transformed and clustered on a population level into tumor and non-tumor supervoxels. The proposed framework is tested on the scans of 18 non-small cell lung cancer patients with a total of 19 tumors and evaluated with respect to manual delineations provided by clinicians. Experiments study the performance of several commonly used clustering algorithms within the framework and provide analysis of (i) the effect of tumor size, (ii) the segmentation errors, (iii) the benefit of across-patient clustering, and (iv) the noise robustness. The proposed framework detected 15 out of 19 tumors in an unsupervised manner. Moreover, performance increased considerably by segmenting across patients, with the mean dice score increasing from 0.169±0.295 (patient-by-patient) to 0.470±0.308 (across-patients). Results demonstrate that both spectral clustering and Manhattan hierarchical clustering have the potential to segment tumors in PET/MRI with a low number of missed tumors and a low number of false-positives, but that spectral clustering seems to be more robust to noise.

@article{doi:10.1021/acs.est.1c01113,
author = {Mamet, Steven D. and Jimmo, Amy and Conway, Alexandra and Teymurazyan, Aram and Talebitaher, Alizera and Papandreou, Zisis and Chang, Yu Fen and Shannon, Whitney and Peak, Derek and Siciliano, Steven D.},
title = {Soil Buffering Capacity Can Be Used To Optimize Biostimulation of Psychrotrophic Hydrocarbon Remediation},
journal = {Environmental Science & Technology},
volume = {55},
number = {14},
pages = {9864-9875},
year = {2021},
doi = {10.1021/acs.est.1c01113},
URL = {https://doi.org/10.1021/acs.est.1c01113},
abstract = { Effective bioremediation of hydrocarbons requires innovative approaches to minimize phosphate precipitation in soils of different buffering capacities. Understanding the mechanisms underlying sustained stimulation of bacterial activity remains a key challenge for optimizing bioremediation—particularly in northern regions. Positron emission tomography (PET) can trace microbial activity within the naturally occurring soil structure of intact soils. Here, we use PET to test two hypotheses: (1) optimizing phosphate bioavailability in soil will outperform a generic biostimulatory solution in promoting hydrocarbon remediation and (2) oligotrophic biostimulation will be more effective than eutrophic approaches. In so doing, we highlight the key bacterial taxa that underlie aerobic and anaerobic hydrocarbon degradation in subarctic soils. In particular, we showed that (i) optimized phosphate bioavailability outperformed generic biostimulatory solutions in promoting hydrocarbon degradation, (ii) oligotrophic biostimulation is more effective than eutrophic approaches, and (iii) optimized biostimulatory solutions stimulated specific soil regions and bacterial consortia. The knowledge gleaned from this study will be crucial in developing field-scale biodegradation treatments for sustained stimulation of bacterial activity in northern regions. }
}

Effective bioremediation of hydrocarbons requires innovative approaches to minimize phosphate precipitation in soils of different buffering capacities. Understanding the mechanisms underlying sustained stimulation of bacterial activity remains a key challenge for optimizing bioremediation—particularly in northern regions. Positron emission tomography (PET) can trace microbial activity within the naturally occurring soil structure of intact soils. Here, we use PET to test two hypotheses: (1) optimizing phosphate bioavailability in soil will outperform a generic biostimulatory solution in promoting hydrocarbon remediation and (2) oligotrophic biostimulation will be more effective than eutrophic approaches. In so doing, we highlight the key bacterial taxa that underlie aerobic and anaerobic hydrocarbon degradation in subarctic soils. In particular, we showed that (i) optimized phosphate bioavailability outperformed generic biostimulatory solutions in promoting hydrocarbon degradation, (ii) oligotrophic biostimulation is more effective than eutrophic approaches, and (iii) optimized biostimulatory solutions stimulated specific soil regions and bacterial consortia. The knowledge gleaned from this study will be crucial in developing field-scale biodegradation treatments for sustained stimulation of bacterial activity in northern regions.

@INPROCEEDINGS{ENIUSWorshop,
	author = {Chang, Yu Fen and Rune Sundset and Boris V. Balakin},
	booktitle = {Virtual ENIUS Worshop. Latest advances in Urinary Stents. Biomaterials, Technology and Coatings.},
	editor = {Federico Soria},
	organization = {EU COST Action CA16217},
	title = {Noninvasive flow visualization and investigation for developing and assessing urinary stents using positron emission particle tracking},
	year = {2021}}

@article{GUTTORMSEN2021S42,
title = {SP-015 - Preliminary evaluation of a novel carbon-11 labeled brain-penetrant EGFR-TKI radiotracer for brain cancer imaging (Abstracts of the Society of Radiopharmaceutical Sciences)},
journal = {Nuclear Medicine and Biology},
volume = {96-97},
pages = {S42-S43},
year = {2021},
issn = {0969-8051},
doi = {https://doi.org/10.1016/S0969-8051(21)00332-2},
url = {https://www.sciencedirect.com/science/article/pii/S0969805121003322},
author = {Yngve Guttormsen and Mathias Kranz and Richard Fjellaksel and Montserrat Martin-Armas and Ana Oteiza and Julia Bihler and Marcel Lindemann and Bård Hoff and Steen Jakobsen and Eirik Sundby and Rune Sundset and Angel Moldes-Anaya}
}

@article {Bihler1456,
	author = {Bihler, Julia and Martin-Armas, Montserrat and Guttormsen, Yngve and Lindemann, Marcel and Oteiza, Ana and Sundset, Rune and Moldes-Anaya, Angel and Kranz, Mathias},
	title = {Development of the first CDK7 specific PET imaging probe based on a carbon-11 labeled pyrazolotriazine derivative for visualization of glioblastoma},
	volume = {62},
	number = {supplement 1},
	pages = {1456--1456},
	year = {2021},
	publisher = {Society of Nuclear Medicine},
	abstract = {1456Introduction: Glioblastoma (GBM) represents the deadliest type of malignancies of the central nervous system. Major challenges such as critical brain locations, the lack of defined tumor margins and heterogeneity, contribute to inevitable tumor recurrence. However, the elucidation of the genomic profile of GBM has enabled the development of receptor specific drugs.1 Among others Cyclin-Dependent Kinase 7 (CDK7) is overexpressed in GBM and may be an interesting target for imaging and diagnosis due to its role in cell proliferation and tumor progression.2 A specific radiotracer for positron emission tomography (PET) might be beneficial in pathological characterization and tumor grading to tailor future treatments to individual tumor profiles. Among published structures the pyrazolotriazine inhibitor LCD3140 represents a potential tracer capable of crossing the blood-brain barrier (BBB).3 Here we describe the synthesis and first successful radiolabeling of this compound. Methods: The pyrazolotriazine standard 1 and precursor 2 for radiosynthesis were prepared in a 7 to 8-step synthetic pathway. Radiosynthesis of [11C]1 was performed by radiomethylation with [11C]MeOTf using tetramethylpiperidine (TMP) as a base in dimethylformamide (DMF) at 85{\textdegree}C for 4 min in a TRACERLAB FX2 C semiautomatic module with a X-Select C18 semipreparative column. The purified fraction was diluted, trapped onto a C18 SPE cartridge, eluted with ethanol, preconcentrated and formulated in isotonic saline. CDK7 Western Blot (WB) analysis in mouse (GL261, GL261 Luc2) and human GBM cell lines (U251) was performed to investigate CDK7 expression. Therefore, whole cell lysates were prepared, 50 μg of total protein was separated by gel electrophoresis, transferred to a nitrocellulose membrane and examined with CDK7 and HRP-linked antibody, respectively. Results: Non-radioactive pyrazolotriazine 1 and the precursor 2 were obtained in 7\% and 5\% overall yields with a purity of \>99\%. Radiomethylation of 2 with [11C]MeOTf resulted in [11C]1 with 19\% (n=1) radiochemical yield (RCY, non-decay corrected, EOB), radiochemical purity (RCP) \>99\%, molar activity (Am) of 121 GBq/{\textmu}mol (n=1) and a total synthesis time of 44 min. CDK7 expression was confirmed in GL261, GL261 Luc2 and U251 cells by Western Blotting rendering the resp. cell lines as suitable for further in vitro and in vivo studies with [11C]1. Conclusion: To our knowledge, the first 11C-labeled radiotracer for CDK7 imaging was successfully synthesized with high RCY, RCP and Am. In addition, we used WB to select appropriate cell lines for further investigation of the radiotracer for in vivo PET imaging. Therefore, studies with brain tumor bearing mice are planned to confirm BBB penetration, metabolic stability and specific binding in GBM under LDC3140 inhibition. Subsequently, the radiotracer will be further developed as tool for CDK7 imaging in brain tumor with PET and therapy monitoring in combined therapy approaches. References: 1 Vleeschouwer S, Glioblastoma. Brisbane (AU); 2017. 2 Meng W, et al. CDK7 inhibition is a novel therapeutic strategy against GBM both in-vitro and in-vivo. Cancer Manag Res. 2018. 3 Eickhoff J, Lead Discovery Center GmbH. Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors. DE WO 2013/128028 Acknowledgements: This study is financed by 180{\textdegree}N the Norwegian Nuclear Medicine Consortium},
	issn = {0161-5505},
	URL = {https://jnm.snmjournals.org/content/62/supplement_1/1456},
	journal = {Journal of Nuclear Medicine}
}

1456Introduction: Glioblastoma (GBM) represents the deadliest type of malignancies of the central nervous system. Major challenges such as critical brain locations, the lack of defined tumor margins and heterogeneity, contribute to inevitable tumor recurrence. However, the elucidation of the genomic profile of GBM has enabled the development of receptor specific drugs.1 Among others Cyclin-Dependent Kinase 7 (CDK7) is overexpressed in GBM and may be an interesting target for imaging and diagnosis due to its role in cell proliferation and tumor progression.2 A specific radiotracer for positron emission tomography (PET) might be beneficial in pathological characterization and tumor grading to tailor future treatments to individual tumor profiles. Among published structures the pyrazolotriazine inhibitor LCD3140 represents a potential tracer capable of crossing the blood-brain barrier (BBB).3 Here we describe the synthesis and first successful radiolabeling of this compound. Methods: The pyrazolotriazine standard 1 and precursor 2 for radiosynthesis were prepared in a 7 to 8-step synthetic pathway. Radiosynthesis of [11C]1 was performed by radiomethylation with [11C]MeOTf using tetramethylpiperidine (TMP) as a base in dimethylformamide (DMF) at 85°C for 4 min in a TRACERLAB FX2 C semiautomatic module with a X-Select C18 semipreparative column. The purified fraction was diluted, trapped onto a C18 SPE cartridge, eluted with ethanol, preconcentrated and formulated in isotonic saline. CDK7 Western Blot (WB) analysis in mouse (GL261, GL261 Luc2) and human GBM cell lines (U251) was performed to investigate CDK7 expression. Therefore, whole cell lysates were prepared, 50 μg of total protein was separated by gel electrophoresis, transferred to a nitrocellulose membrane and examined with CDK7 and HRP-linked antibody, respectively. Results: Non-radioactive pyrazolotriazine 1 and the precursor 2 were obtained in 7% and 5% overall yields with a purity of >99%. Radiomethylation of 2 with [11C]MeOTf resulted in [11C]1 with 19% (n=1) radiochemical yield (RCY, non-decay corrected, EOB), radiochemical purity (RCP) >99%, molar activity (Am) of 121 GBq/\textmumol (n=1) and a total synthesis time of 44 min. CDK7 expression was confirmed in GL261, GL261 Luc2 and U251 cells by Western Blotting rendering the resp. cell lines as suitable for further in vitro and in vivo studies with [11C]1. Conclusion: To our knowledge, the first 11C-labeled radiotracer for CDK7 imaging was successfully synthesized with high RCY, RCP and Am. In addition, we used WB to select appropriate cell lines for further investigation of the radiotracer for in vivo PET imaging. Therefore, studies with brain tumor bearing mice are planned to confirm BBB penetration, metabolic stability and specific binding in GBM under LDC3140 inhibition. Subsequently, the radiotracer will be further developed as tool for CDK7 imaging in brain tumor with PET and therapy monitoring in combined therapy approaches. References: 1 Vleeschouwer S, Glioblastoma. Brisbane (AU); 2017. 2 Meng W, et al. CDK7 inhibition is a novel therapeutic strategy against GBM both in-vitro and in-vivo. Cancer Manag Res. 2018. 3 Eickhoff J, Lead Discovery Center GmbH. Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors. DE WO 2013/128028 Acknowledgements: This study is financed by 180°N the Norwegian Nuclear Medicine Consortium

@article {Guttormsen1476,
	author = {Guttormsen, Yngve and Moldes-Anaya, Angel and Fjellaksel, Richard and Oteiza, Ana and Martin-Armas, Montserrat and Lindemann, Marcel and Bihler, Julia and Hoff, Bard Helge and Jakobsen, Steen and Sundby, Eirik and Sundset, Rune and Kranz, Mathias},
	title = {Development of a carbon-11 labeled thienopyrimidine based radioligand for EGFR-tyrosine-kinase-inhibitor (TKI) specific PET imaging of glioblastoma},
	volume = {62},
	number = {supplement 1},
	pages = {1476--1476},
	year = {2021},
	publisher = {Society of Nuclear Medicine},
	abstract = {1476Introduction: Glioblastoma (GBM) is a devastating cancer disease affecting 3 of 100000 Europeans. Furthermore, GBM accounts for 25\% of all malignant tumors of the central nervous system. Combined approaches, including surgery, chemotherapy and external radiation have shown to only slightly prolong the survival of patients to a maximum of 14 months after first diagnosis. Reasons for this ineffective treatment are the tumor growth pattern, its invasive vascularization and high heterogenicity. Hence, a specific PET radioligand for visualization of GBM biomarkers like EGFR-TKI might help to improve diagnostic and therapy monitoring following anti-angiogenic treatment. Here, we describe the development of a thienopyrimidine based radiotracer from a library of EGFR-TKI from Bugge et al. [1] and its subsequent in vivo characterization and visualization. Methods: The non-radioactive thienopyrimidine standard 1 and the desmethyl precursor 2 were synthesized according to published methods [1]. Radiosynthesis of [11C]1 was achieved by methylation with [11C]MeI using NaOH as a base in DMSO at 100 {\textdegree}C for 3-5 min in a TRACERlab FX2C module. [11C]1 was purified by preparative HPLC and further passed through a C-18 Sep-Pak cartridge. The eluted ethanolic extract was evaporated to approximately 30 {\textmu}l and reconstituted to a final volume of 400 {\textmu}l with 1\% polysorbate 80 in isotonic saline for in vivo application. The cell association was evaluated at room temperature by in vitro saturation studies in A431 cells using Erlotinib as a blocking agent. Radiotracer biodistribution in vivo was studied by 1 h dynamic simultaneous PET/MR imaging (DRYMAG 7024/PET, MRsolutions, Guildford, UK) following [11C]1 i.v. injection (5.8{\textpm}4.3 MBq) in healthy female CD1 mice (31.7{\textpm}4.2 g, n=4). Initial metabolism was studied in healthy CD1 mice (n=3) administered with 130{\textpm}45 MBq [11C]1. Animals were sacrificed five minutes after administration and brain, blood and liver were collected and homogenized in ACN/H2O (7:3). Tissue homogenates and plasma were further analyzed by HPLC-RAD-MS. Results: Compounds 1 and 2 were obtained in 29\% and 39\% overall yields over six steps. Radiomethylation of 2 with [11C]MeI resulted in [11C]1 with 8.9{\textpm}3.8\% (n=12) radiochemical yield (non-decay corrected, EOB) in 45 min total synthesis time. The radiochemical purity was found to be \>99\% (n=12) and the molar activity achieved was 115{\textpm}80 GBq/{\textmu}mol (n=12). In vitro stability in human serum shows \>99\% intact [11C]1 after 30 minutes. Compound [11C]1 showed uptake in EGFR overexpressing A431 cells which was displaceable with Erlotinib. The radiotracer showed blood-brain-barrier (BBB) penetration and nonsignificant amounts of radiometabolites were detected with the methods applied. However, possible hydroxylated metabolites were found in trace amounts by LC/MS analysis. PET/MR imaging revealed high brain uptake (SUV=1.4 at 5 min p.i.) followed by a wash-out during the investigation time. Conclusion: Our preliminary PET/MR and ex vivo metabolism results indicate that compound [11C]1 crosses the BBB and that non-significant radiometabolite amounts are detected with the analysis methods applied . Cellular uptake in A431 cells renders [11C]1 suitable for subsequent in vivo studies. Hence, further studies in brain tumor bearing animals are planned to show specific binding to GBM tissue and to further develop the radiotracer as a tool for brain tumor imaging with PET. 1. Bugge, S., et al., Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor. European Journal of Medicinal Chemistry, 2014. 75: p. 354-374. Acknowledgements: This study is financed by 180{\textdegree}N the Norwegian Nuclear Medicine Consortium},
	issn = {0161-5505},
	URL = {https://jnm.snmjournals.org/content/62/supplement_1/1476},
	journal = {Journal of Nuclear Medicine}
}

1476Introduction: Glioblastoma (GBM) is a devastating cancer disease affecting 3 of 100000 Europeans. Furthermore, GBM accounts for 25% of all malignant tumors of the central nervous system. Combined approaches, including surgery, chemotherapy and external radiation have shown to only slightly prolong the survival of patients to a maximum of 14 months after first diagnosis. Reasons for this ineffective treatment are the tumor growth pattern, its invasive vascularization and high heterogenicity. Hence, a specific PET radioligand for visualization of GBM biomarkers like EGFR-TKI might help to improve diagnostic and therapy monitoring following anti-angiogenic treatment. Here, we describe the development of a thienopyrimidine based radiotracer from a library of EGFR-TKI from Bugge et al. [1] and its subsequent in vivo characterization and visualization. Methods: The non-radioactive thienopyrimidine standard 1 and the desmethyl precursor 2 were synthesized according to published methods [1]. Radiosynthesis of [11C]1 was achieved by methylation with [11C]MeI using NaOH as a base in DMSO at 100 °C for 3-5 min in a TRACERlab FX2C module. [11C]1 was purified by preparative HPLC and further passed through a C-18 Sep-Pak cartridge. The eluted ethanolic extract was evaporated to approximately 30 \textmul and reconstituted to a final volume of 400 \textmul with 1% polysorbate 80 in isotonic saline for in vivo application. The cell association was evaluated at room temperature by in vitro saturation studies in A431 cells using Erlotinib as a blocking agent. Radiotracer biodistribution in vivo was studied by 1 h dynamic simultaneous PET/MR imaging (DRYMAG 7024/PET, MRsolutions, Guildford, UK) following [11C]1 i.v. injection (5.8\textpm4.3 MBq) in healthy female CD1 mice (31.7\textpm4.2 g, n=4). Initial metabolism was studied in healthy CD1 mice (n=3) administered with 130\textpm45 MBq [11C]1. Animals were sacrificed five minutes after administration and brain, blood and liver were collected and homogenized in ACN/H2O (7:3). Tissue homogenates and plasma were further analyzed by HPLC-RAD-MS. Results: Compounds 1 and 2 were obtained in 29% and 39% overall yields over six steps. Radiomethylation of 2 with [11C]MeI resulted in [11C]1 with 8.9\textpm3.8% (n=12) radiochemical yield (non-decay corrected, EOB) in 45 min total synthesis time. The radiochemical purity was found to be >99% (n=12) and the molar activity achieved was 115\textpm80 GBq/\textmumol (n=12). In vitro stability in human serum shows >99% intact [11C]1 after 30 minutes. Compound [11C]1 showed uptake in EGFR overexpressing A431 cells which was displaceable with Erlotinib. The radiotracer showed blood-brain-barrier (BBB) penetration and nonsignificant amounts of radiometabolites were detected with the methods applied. However, possible hydroxylated metabolites were found in trace amounts by LC/MS analysis. PET/MR imaging revealed high brain uptake (SUV=1.4 at 5 min p.i.) followed by a wash-out during the investigation time. Conclusion: Our preliminary PET/MR and ex vivo metabolism results indicate that compound [11C]1 crosses the BBB and that non-significant radiometabolite amounts are detected with the analysis methods applied . Cellular uptake in A431 cells renders [11C]1 suitable for subsequent in vivo studies. Hence, further studies in brain tumor bearing animals are planned to show specific binding to GBM tissue and to further develop the radiotracer as a tool for brain tumor imaging with PET. 1. Bugge, S., et al., Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor. European Journal of Medicinal Chemistry, 2014. 75: p. 354-374. Acknowledgements: This study is financed by 180°N the Norwegian Nuclear Medicine Consortium

@article{Kuttner_2020,
	doi = {10.1088/2057-1976/ab6496},
	url = {https://doi.org/10.1088/2057-1976/ab6496},
	year = 2020,
	month = {jan},
	publisher = {{IOP} Publishing},
	volume = {6},
	number = {1},
	pages = {015020},
	author = {Samuel Kuttner and Kristoffer Knutsen Wickstrøm and Gustav Kalda and S Esmaeil Dorraji and Montserrat Martin-Armas and Ana Oteiza and Robert Jenssen and Kristin Fenton and Rune Sundset and Jan Axelsson},
	title = {Machine learning derived input-function in a dynamic 18F-{FDG} {PET} study of mice},
	journal = {Biomedical Physics & Engineering Express},
	abstract = {Tracer kinetic modelling, based on dynamic 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is used to quantify glucose metabolism in humans and animals. Knowledge of the arterial input-function (AIF) is required for such measurements. Our aim was to explore two non-invasive machine learning-based models, for AIF prediction in a small-animal dynamic FDG PET study. 7 tissue regions were delineated in images from 68 FDG PET/computed tomography mouse scans. Two machine learning-based models were trained for AIF prediction, based on Gaussian processes (GP) and a long short-term memory (LSTM) recurrent neural network, respectively. Because blood data were unavailable, a reference AIF was formed by fitting an established AIF model to vena cava and left ventricle image data. The predicted and reference AIFs were compared by the area under curve (AUC) and root mean square error (RMSE). Net-influx rate constants, Ki, were calculated with a two-tissue compartment model, using both predicted and reference AIFs for three tissue regions in each mouse scan, and compared by means of error, ratio, correlation coefficient, P value and Bland-Altman analysis. The impact of different tissue regions on AIF prediction was evaluated by training a GP and an LSTM model on subsets of tissue regions, and calculating the RMSE between the reference and the predicted AIF curve. Both models generated AIFs with AUCs similar to reference. The LSTM models resulted in lower AIF RMSE, compared to GP. Ki from both models agreed well with reference values, with no significant differences. Myocardium was highlighted as important for AIF prediction, but AIFs with similar RMSE were obtained also without myocardium in the input data. Machine learning can be used for accurate and non-invasive prediction of an image-derived reference AIF in FDG studies of mice. We recommend the LSTM approach, as this model predicts AIFs with lower errors, compared to GP.}
}

Tracer kinetic modelling, based on dynamic 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is used to quantify glucose metabolism in humans and animals. Knowledge of the arterial input-function (AIF) is required for such measurements. Our aim was to explore two non-invasive machine learning-based models, for AIF prediction in a small-animal dynamic FDG PET study. 7 tissue regions were delineated in images from 68 FDG PET/computed tomography mouse scans. Two machine learning-based models were trained for AIF prediction, based on Gaussian processes (GP) and a long short-term memory (LSTM) recurrent neural network, respectively. Because blood data were unavailable, a reference AIF was formed by fitting an established AIF model to vena cava and left ventricle image data. The predicted and reference AIFs were compared by the area under curve (AUC) and root mean square error (RMSE). Net-influx rate constants, Ki, were calculated with a two-tissue compartment model, using both predicted and reference AIFs for three tissue regions in each mouse scan, and compared by means of error, ratio, correlation coefficient, P value and Bland-Altman analysis. The impact of different tissue regions on AIF prediction was evaluated by training a GP and an LSTM model on subsets of tissue regions, and calculating the RMSE between the reference and the predicted AIF curve. Both models generated AIFs with AUCs similar to reference. The LSTM models resulted in lower AIF RMSE, compared to GP. Ki from both models agreed well with reference values, with no significant differences. Myocardium was highlighted as important for AIF prediction, but AIFs with similar RMSE were obtained also without myocardium in the input data. Machine learning can be used for accurate and non-invasive prediction of an image-derived reference AIF in FDG studies of mice. We recommend the LSTM approach, as this model predicts AIFs with lower errors, compared to GP.

@article{https://doi.org/10.1002/cmdc.202000256,
author = {Bekker, Roberto B. W. and Fjellaksel, Richard and Hjornevik, Trine and Nuruddin, Syed and Rafique, Waqas and Hansen, Jørn H. and Sundset, Rune and Haraldsen, Ira H. and Riss, Patrick J.},
title = {Discovery of a Lead Brain-Penetrating Gonadotropin-Releasing Hormone Receptor Antagonist with Saturable Binding in Brain},
journal = {ChemMedChem},
volume = {15},
number = {17},
pages = {1624-1628},
keywords = {elagolix, fluorine-18, GnRH−R, GnRH, PET},
doi = {https://doi.org/10.1002/cmdc.202000256},
url = {https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cmdc.202000256},
eprint = {https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000256},
abstract = {Abstract We report the synthesis, radiosynthesis and biological characterisation of two gonadotropin-releasing hormone receptor (GnRH−R) antagonists with nanomolar binding affinity. A small library of GnRH−R antagonists was synthesised in 20–67 \% overall yield with the aim of identifying a high-affinity antagonist capable of crossing the blood–brain barrier. Binding affinity to rat GnRH−R was determined by autoradiography in competitive-binding studies against [125I]buserelin, and inhibition constants were calculated by using the Cheng–Prusoff equation. The radioligands were obtained in 46–79 \% radiochemical yield and >95 \% purity and with a molar activity of 19–38 MBq/nmol by direct nucleophilic radiofluorination. Positron emission tomography imaging in rat under baseline conditions in comparison to pretreatment with a receptor-saturating dose of GnRH antagonist revealed saturable uptake (0.1 \%ID/mL) into the brain.},
year = {2020}
}

Abstract We report the synthesis, radiosynthesis and biological characterisation of two gonadotropin-releasing hormone receptor (GnRH−R) antagonists with nanomolar binding affinity. A small library of GnRH−R antagonists was synthesised in 20–67 % overall yield with the aim of identifying a high-affinity antagonist capable of crossing the blood–brain barrier. Binding affinity to rat GnRH−R was determined by autoradiography in competitive-binding studies against [125I]buserelin, and inhibition constants were calculated by using the Cheng–Prusoff equation. The radioligands were obtained in 46–79 % radiochemical yield and >95 % purity and with a molar activity of 19–38 MBq/nmol by direct nucleophilic radiofluorination. Positron emission tomography imaging in rat under baseline conditions in comparison to pretreatment with a receptor-saturating dose of GnRH antagonist revealed saturable uptake (0.1 %ID/mL) into the brain.

@article{baagenholm2020diagnostic,
  title={Diagnostic imaging and ionizing radiation exposure in a level 1 trauma centre population met with trauma team activation: A one-year patient record audit},
  author={B{å}genholm, Anna and L{ø}vhaugen, P{å}l and Sundset, Rune and Ingebrigtsen, Tor},
  journal={Radiation Protection Dosimetry},
  year={2020},
  doi={10.1093/rpd/ncaa010}
}

@article{berntsen2020perfluoroalkyl,
  title={Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons},
  author={Berntsen, Hanne Friis and Moldes-Anaya, Angel and Bjørklund, Cesilie Granum and Ragazzi, Lorenzo and Haug, Trude and Strandabø, Rønnaug and Verhaegen, Steven and Paulsen, Ragnhild Elisabeth and Ropstad, Erik and Tasker, R Andrew},
  journal={Toxicology},
  pages={152610},
  year={2020},
  publisher={Elsevier},
  Doi = {10.1016/j.tox.2020.152610}
}
%% ---------------Moldes-Anaya, Angel end---------------------
%%--------------------------Vangberg start---------------------------

@article{Chang_2020,
	doi = {10.1088/1742-6596/1689/1/012019},
	url = {https://doi.org/10.1088/1742-6596/1689/1/012019},
	year = 2020,
	publisher = {{IOP} Publishing},
	volume = {1689},
	pages = {012019},
	author = {Chang, Yu Fen and Boris V. Balakin},
	title = {Novel Bio-compatible Tracers for Positron Emission Particle Tracking},
	journal = {Journal of Physics: Conference Series},
	abstract = {To study the flow of objects in opaque flow processes, the PEPT (positron emission particle tracking) technique may be utilized. The PEPT technique is based on the same principle of positron emission tomography (PET). Both techniques detect the characteristic back-to-back gamma pairs caused by positron-electron annihilation. PEPT allows tracking of β+ - activated objects (tracers) with high spatial (microns) and temporal resolutions (milliseconds). This makes the technique promising in a number of medical applications that require observation of fast transient phenomena e.g. heart and brain hemodynamics, the aerodynamics of respiratory tract etc. However, a majority of PEPT-tracers used nowadays are tailored for industrial applications and are based on solid particles of a micrometric size, which are hardly suitable for in-vivo tests. In this contribution, we propose new bio-compatible tracers. The tracers are based on frozen radioactive solutions rather than activated solids. We produced a number of millimetre-sized ice tracers dispersing the droplets of radioactive solution in oil at negative temperatures. In this preliminary study, we demonstrate how the tracers behave in a settling column and in an agitated vessel. The PEPT-tracks are presented together with a supplementary numerical analysis that was conducted in order to estimate the freezing time of the droplets.}
}

To study the flow of objects in opaque flow processes, the PEPT (positron emission particle tracking) technique may be utilized. The PEPT technique is based on the same principle of positron emission tomography (PET). Both techniques detect the characteristic back-to-back gamma pairs caused by positron-electron annihilation. PEPT allows tracking of β+ - activated objects (tracers) with high spatial (microns) and temporal resolutions (milliseconds). This makes the technique promising in a number of medical applications that require observation of fast transient phenomena e.g. heart and brain hemodynamics, the aerodynamics of respiratory tract etc. However, a majority of PEPT-tracers used nowadays are tailored for industrial applications and are based on solid particles of a micrometric size, which are hardly suitable for in-vivo tests. In this contribution, we propose new bio-compatible tracers. The tracers are based on frozen radioactive solutions rather than activated solids. We produced a number of millimetre-sized ice tracers dispersing the droplets of radioactive solution in oil at negative temperatures. In this preliminary study, we demonstrate how the tracers behave in a settling column and in an agitated vessel. The PEPT-tracks are presented together with a supplementary numerical analysis that was conducted in order to estimate the freezing time of the droplets.

@Article{molecules25204848,
AUTHOR = {Guttormsen, Yngve and Fairhurst, Magnus E. and Pandey, Sunil K. and Isaksson, Johan and Haug, Bengt Erik and Bayer, Annette},
TITLE = {Total Synthesis of Phorbazole B},
JOURNAL = {Molecules},
VOLUME = {25},
YEAR = {2020},
NUMBER = {20},
ARTICLE-NUMBER = {4848},
URL = {https://www.mdpi.com/1420-3049/25/20/4848},
PubMedID = {33096668},
ISSN = {1420-3049},
ABSTRACT = {Phorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the trichlorinated phorbazole B using late stage electrophilic chlorination was developed. The synthesis relied on the use of an oxazole precursor, which was protected with an iodine in the reactive 4-position, followed by complete chlorination of all pyrrole positions. Attempts to prepare phorbazole A and C, which contain a 3,4-dichlorinated pyrrole, were unsuccessful as the desired chlorination pattern on the pyrrole could not be obtained. The identities of the dichlorinated intermediates and products were determined using NMR techniques including NOESY/ROESY, 1,1-ADEQUATE and high-resolution CLIP-HSQMBC.},
DOI = {10.3390/molecules25204848}
}

Phorbazoles are polychlorinated heterocyclic secondary metabolites isolated from a marine sponge and several of these natural products have shown inhibitory activity against cancer cells. In this work, a synthesis of the trichlorinated phorbazole B using late stage electrophilic chlorination was developed. The synthesis relied on the use of an oxazole precursor, which was protected with an iodine in the reactive 4-position, followed by complete chlorination of all pyrrole positions. Attempts to prepare phorbazole A and C, which contain a 3,4-dichlorinated pyrrole, were unsuccessful as the desired chlorination pattern on the pyrrole could not be obtained. The identities of the dichlorinated intermediates and products were determined using NMR techniques including NOESY/ROESY, 1,1-ADEQUATE and high-resolution CLIP-HSQMBC.

@article{nanni202018,
  title={[18 F] Fluciclovine PET/CT: joint EANM and SNMMI procedure guideline for prostate cancer imaging—version 1.0},
  author={Nanni, Cristina and Zanoni, Lucia and Bach-Gansmo, Tore and Minn, Heikki and Willoch, Frode and Bogsrud, Trond Velde and Edward, Ephraim Parent and Savir-Baruch, Bital and Teoh, Eugene and Ingram, Fenton and Stefano Fanti and David M. Schuster },
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  volume={47},
  number={3},
  pages={579--591},
  year={2020},
  publisher={Springer},
  Doi={10.1007/s00259-019-04614-y}
}

@article {Cai462,
	author = {Cai, Zhengxin and Drake, Lindsey and Naganawa, Mika and Najafzadeh, Soheila and Pracitto, Richard and Lindemann, Marcel and Li, Songye and Ropchan, Jim and Labaree, David and Emery, Paul and Dias, Mark and Henry, Shannan and Nabulsi, Nabeel and Matuskey, David and Hillmer, Ansel and Carson, Richard and Huang, Yiyun},
	title = {First-in-Human study of [18F]SynVesT-2, a novel SV2A radioligand with fast kinetics and high specific binding signals},
	volume = {61},
	number = {supplement 1},
	pages = {462--462},
	year = {2020},
	publisher = {Society of Nuclear Medicine},
	abstract = {462Objectives: Early stage Alzheimer{\textquoteright}s disease (AD) is associated with regional synapse loss. PET imaging agents for synaptic vesicle glycoprotein 2A (SV2A), [11C]UCB-J [1] and [18F]UCB-H [2], have confirmed in vivo synaptic density loss in hippocampus of AD subjects. We recently developed an alternative radioligand, [18F]SynVestT-2 ([18F]SDM-2), with faster kinetics and lower nonspecific binding in the non-human primate brain. The aim of this study was to evaluate this SV2A tracer in humans in comparison with [11C]UCB-J, [18F]SynVesT-1 ([18F]SDM-8), and [18F]UCB-H. Methods: PET scans with [18F]SynVesT-2 were acquired for 120 min on a High Resolution Research Tomograph (HRRT) scanner. Arterial blood samples were drawn for metabolite analysis and construction of the arterial input function (AIF). Regions of interest (ROIs) were defined with an atlas and individual subjects{\textquoteright} MR image to generate time-activity curves (TACs). TACs were then fitted with 1- and 2- tissue compartment (1TC, 2TC) models to derive regional distribution volumes (VT) using the metabolite corrected AIF. Nondisplaceable binding potential (BPND) was calculated using centrum semiovale (white matter) as the reference region [3]. Results: Injected activity dose of [18F]SynVesT-2 was 4.78 +/- 0.15 mCi (n= 2). The parent fraction of [18F]SynVesT-2 in plasma was 23 +/- 4\% (n=2) at 30 min after tracer injection, similar to that of [11C]UCB-J (27 +/- 9\%, n=9) and [18F]SynVesT-1 (25 +/- 6\%, n=3). Plasma free fraction (fp) was 0.35 +/- 0.06 (n=2). As predicted by our nonhuman primate studies, [18F]SynVesT-2 displayed high brain uptake and fast kinetics, with peak SUV of 8 in the dorsolateral prefrontal cortex (dlPFC) and putamen at 7 min post injection. Regional TACs were fitted well with the 1TC model; while 2TC model produced unreliable VT values in some regions. K1 values (mL/cm3/min) from the 1TC model ranged from 0.12 (centrum semiovale) to 0.38 (thalamus) for [18F]SynVesT-2 and were similar to those of [18F]SynVesT-1 (0.11-0.34) and UCB-J (0.1-0.33). 1TC VT values (mL/cm3) ranged from 2.1 (centrum semiovale) to 8.1 (putamen) and were significantly lower than those of [18F]SynVesT-1 (~53\% of the mean value) and [11C]UCB-J (~58\%). As a measure of specific binding, mean BPND values of [18F]SynVesT-2 were 42\% lower than those of [18F]SynVesT-1, and 24\% lower than those of [11C]UCB-J (table 1), but three fold higher than those of UCB-H [4]. Importantly, regional VT of [18F]SynVesT-2 can be estimated reliably with 20 min of scan time(-1{\textpm}5\% different from 120-min value), much shorter than the 60 min required for [11C]UCB-J and [18F]SynVesT-1 [5]. Conclusions: The novel radiotracer [18F]SynVesT-2 demonstrates good imaging characteristics in humans with high brain uptake, fast kinetics, and high specific binding. These pharmacokinetic properties would shorten the length of a required scanning time and possibly negate the need for arterial blood sampling, decreasing the burden on this patient population and facilitate large scale clinical trials.},
	issn = {0161-5505},
	URL = {https://jnm.snmjournals.org/content/61/supplement_1/462},
	journal = {Journal of Nuclear Medicine}
}

462Objectives: Early stage Alzheimer\textquoterights disease (AD) is associated with regional synapse loss. PET imaging agents for synaptic vesicle glycoprotein 2A (SV2A), [11C]UCB-J [1] and [18F]UCB-H [2], have confirmed in vivo synaptic density loss in hippocampus of AD subjects. We recently developed an alternative radioligand, [18F]SynVestT-2 ([18F]SDM-2), with faster kinetics and lower nonspecific binding in the non-human primate brain. The aim of this study was to evaluate this SV2A tracer in humans in comparison with [11C]UCB-J, [18F]SynVesT-1 ([18F]SDM-8), and [18F]UCB-H. Methods: PET scans with [18F]SynVesT-2 were acquired for 120 min on a High Resolution Research Tomograph (HRRT) scanner. Arterial blood samples were drawn for metabolite analysis and construction of the arterial input function (AIF). Regions of interest (ROIs) were defined with an atlas and individual subjects\textquoteright MR image to generate time-activity curves (TACs). TACs were then fitted with 1- and 2- tissue compartment (1TC, 2TC) models to derive regional distribution volumes (VT) using the metabolite corrected AIF. Nondisplaceable binding potential (BPND) was calculated using centrum semiovale (white matter) as the reference region [3]. Results: Injected activity dose of [18F]SynVesT-2 was 4.78 +/- 0.15 mCi (n= 2). The parent fraction of [18F]SynVesT-2 in plasma was 23 +/- 4% (n=2) at 30 min after tracer injection, similar to that of [11C]UCB-J (27 +/- 9%, n=9) and [18F]SynVesT-1 (25 +/- 6%, n=3). Plasma free fraction (fp) was 0.35 +/- 0.06 (n=2). As predicted by our nonhuman primate studies, [18F]SynVesT-2 displayed high brain uptake and fast kinetics, with peak SUV of 8 in the dorsolateral prefrontal cortex (dlPFC) and putamen at 7 min post injection. Regional TACs were fitted well with the 1TC model; while 2TC model produced unreliable VT values in some regions. K1 values (mL/cm3/min) from the 1TC model ranged from 0.12 (centrum semiovale) to 0.38 (thalamus) for [18F]SynVesT-2 and were similar to those of [18F]SynVesT-1 (0.11-0.34) and UCB-J (0.1-0.33). 1TC VT values (mL/cm3) ranged from 2.1 (centrum semiovale) to 8.1 (putamen) and were significantly lower than those of [18F]SynVesT-1 ( 53% of the mean value) and [11C]UCB-J ( 58%). As a measure of specific binding, mean BPND values of [18F]SynVesT-2 were 42% lower than those of [18F]SynVesT-1, and 24% lower than those of [11C]UCB-J (table 1), but three fold higher than those of UCB-H [4]. Importantly, regional VT of [18F]SynVesT-2 can be estimated reliably with 20 min of scan time(-1\textpm5% different from 120-min value), much shorter than the 60 min required for [11C]UCB-J and [18F]SynVesT-1 [5]. Conclusions: The novel radiotracer [18F]SynVesT-2 demonstrates good imaging characteristics in humans with high brain uptake, fast kinetics, and high specific binding. These pharmacokinetic properties would shorten the length of a required scanning time and possibly negate the need for arterial blood sampling, decreasing the burden on this patient population and facilitate large scale clinical trials.

@article{wu2020feasibility,
  title={Feasibility study of PET dynamic imaging of [18F] DHMT for quantification of reactive oxygen species in the myocardium of large animals.},
  author={Wu, J and Boutagy, NE and Cai, Z and Lin, SF and Zheng, MQ and Feher, A and Stendahl, JC and Kapinos, M and Gallezot, JD and Liu, H and Tim Mulnix and Wenjie Zhang and Marcel Lindemann and Jo-Ku Teng and Edward J Miller and Yiyun Huang and Richard E Carson and Albert J Sinusas and Chi Liu},
  journal={Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology},
  year={2020},
  Doi={10.1007/s12350-020-02184-3}
}

@article{lindemann2020development,
  title={Development of a Radiofluorinated Adenosine A2B Receptor Antagonist as Potential Ligand for PET Imaging},
  author={Lindemann, Marcel and Moldovan, Rare{\c{s}}-Petru and Hinz, Sonja and Deuther-Conrad, Winnie and G{\"u}ndel, Daniel and Dukic-Stefanovic, Sladjana and Toussaint, Magali and Teodoro, Rodrigo and Juhl, Cathleen and Steinbach, J{\"o}rg and others},
  journal={International Journal of Molecular Sciences},
  volume={21},
  number={9},
  pages={3197},
  year={2020},
  publisher={Multidisciplinary Digital Publishing Institute},
  Doi={10.3390/ijms21093197}
}

@article{cai2020synthesis,
  title={Synthesis and Preclinical Evaluation of an 18F-Labeled Synaptic Vesicle Glycoprotein 2A PET Imaging Probe:[18F] SynVesT-2},
  author={Cai, Zhengxin and Li, Songye and Zhang, Wenjie and Pracitto, Richard and Wu, Xiaoai and Baum, Evan and Finnema, Sjoerd J and Holden, Daniel and Toyonaga, Takuya and Lin, Shu-fei and Marcel Lindemann and Anupama Shirali and David C. Labaree and Jim Ropchan and Nabeel Nabulsi and Richard E. Carson and Yiyun Huang},
  journal={ACS Chemical Neuroscience},
  volume={11},
  number={4},
  pages={592--603},
  year={2020},
  publisher={ACS Publications},
  Doi={10.1021/acschemneuro.9b00618}
}

@article{doi:10.1139/cjpp-2019-0024,
author = {Boardman, Neoma T. and Falck, Aleksander Tank and Lund, Trine and Chu, Xi and Martin-Armas, Montserrat and Norvik, Jon V. and Jenssen, Trond G. and Ytrehus, Kirsti},
title = {Human concentrations of uric acid scavenges adaptive and maladaptive reactive oxygen species in isolated rat hearts subjected to ischemic stress},
journal = {Canadian Journal of Physiology and Pharmacology},
volume = {98},
number = {3},
pages = {139-146},
year = {2020},
doi = {10.1139/cjpp-2019-0024},
URL = {https://doi.org/10.1139/cjpp-2019-0024},
doi = {10.1139/cjpp-2019-0024},
abstract = { Uric acid is a purine degradation product but also an important antioxidant and reactive oxygen species (ROS) scavenger. Experimental settings that mimic myocardial ischemia–reperfusion have not included uric acid despite that it is always present in human extracellular fluid and plasma. We hypothesized that uric acid has an important role in myocardial ROS scavenging. Here, we tested the cardiac response to uric acid on infarct size following ischemia–reperfusion with and without exacerbated oxidative stress due to acute pressure overload and during preconditioning. We also examined mitochondrial respiration and ROS-induced mitochondrial permeability transition pore opening. Under exacerbated ROS stress induced by high-pressure perfusion, uric acid lowered oxidative stress and reduced infarct size. In contrast, uric acid blocked cardioprotection induced by ischemic preconditioning. However, this effect was reversed by probenecid, an inhibitor of cellular uptake of uric acid. In accordance, in intact cardiomyocytes, extracellular uric acid reduced the susceptibility of mitochondria towards opening of the permeability transition pore, suggesting that uric acid may prevent ischemia–reperfusion injury due to scavenging of maladaptive ROS. Moreover, as uric acid also scavenges adaptive ROS, this may interfere with preconditioning. Altogether, uric acid might be a confounder when translating preclinical experimental results into clinical treatment. }
}
%% ---------------Montse end---------------------
%--------------kranz----------------------------------------

Uric acid is a purine degradation product but also an important antioxidant and reactive oxygen species (ROS) scavenger. Experimental settings that mimic myocardial ischemia–reperfusion have not included uric acid despite that it is always present in human extracellular fluid and plasma. We hypothesized that uric acid has an important role in myocardial ROS scavenging. Here, we tested the cardiac response to uric acid on infarct size following ischemia–reperfusion with and without exacerbated oxidative stress due to acute pressure overload and during preconditioning. We also examined mitochondrial respiration and ROS-induced mitochondrial permeability transition pore opening. Under exacerbated ROS stress induced by high-pressure perfusion, uric acid lowered oxidative stress and reduced infarct size. In contrast, uric acid blocked cardioprotection induced by ischemic preconditioning. However, this effect was reversed by probenecid, an inhibitor of cellular uptake of uric acid. In accordance, in intact cardiomyocytes, extracellular uric acid reduced the susceptibility of mitochondria towards opening of the permeability transition pore, suggesting that uric acid may prevent ischemia–reperfusion injury due to scavenging of maladaptive ROS. Moreover, as uric acid also scavenges adaptive ROS, this may interfere with preconditioning. Altogether, uric acid might be a confounder when translating preclinical experimental results into clinical treatment.

@article{sattler2020preclinical,
  title={Preclinical Incorporation Dosimetry of [18F] FLUDA-a novel 18F-labeled tracer for PET imaging of the expression of the adenosine A2A receptor (A2AR)},
  author={Sattler, Bernhard and Kranz, Mathias and Lai, Thu Hang and Guendel, Daniel and Toussaint, Magali and Schroeder, Susann and Moldovan, Rares-Petru and Deuther-Conrad, Winnie and Teodoro, Rodrigo and Sabri, Osama and others},
  journal={Journal of Nuclear Medicine},
  volume={61},
  number={supplement 1},
  pages={1014--1014},
  year={2020},
  publisher={Soc Nuclear Med}
}

@article{teodoro2020towards,
  title={Towards the clinical translation of the adenosine A2A receptor (A2AR) radiotracer [18F] FLUDA: pre-clinical perspectives},
  author={Teodoro, Rodrigo and Lai, Thu Hang and Toussaint, Magali and G{\~A}$1/4$ndel, Daniel and Dukic-Stefanovic, Sladjana and Deuther-Conrad, Winnie and Kranz, Mathias and Moldovan, Rare{\c{s}}-Petru and Brust, Peter and others},
  journal={Journal of Nuclear Medicine},
  volume={61},
  number={supplement 1},
  pages={267--267},
  year={2020},
  publisher={Soc Nuclear Med}
}

@article{gundel2020preclinical,
  title={Preclinical in vivo evaluation of [18] FACH in piglets: A new radiotracer for imaging of monocarboxylate transporters (MCTs)},
  author={G{\"u}ndel, D and Sadeghzadeh, M and Wenzel, B and Sattler, B and Deuther-Conrad, W and Kranz, M and Toussaint, M and Ludwig, FA and Moldovan, RP and Teodoro, R and others},
  journal={Nuklearmedizin},
  volume={59},
  number={02},
  pages={P65},
  year={2020},
  publisher={{\copyright} Georg Thieme Verlag KG}
}

@article{toussaint2020sigma,
  title={Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using (S)-(-)-[18F] Fluspidine in Glioblastoma},
  author={Toussaint, Magali and Deuther-Conrad, Winnie and Kranz, Mathias and Fischer, Steffen and Ludwig, Friedrich-Alexander and Juratli, Tareq A and Patt, Marianne and W{\"u}nsch, Bernhard and Schackert, Gabriele and Sabri, Osama and others},
  journal={Molecules},
  volume={25},
  number={9},
  pages={2170},
  year={2020},
  publisher={Multidisciplinary Digital Publishing Institute}
}

@article{sattler2020preclinical,
  title={Preclinical Incorporation Dosimetry of [18F] FACH—A Novel 18F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET},
  author={Sattler, Bernhard and Kranz, Mathias and Wenzel, Barbara and Jain, Nalin T and Moldovan, Rare{\c{s}}-Petru and Toussaint, Magali and Deuther-Conrad, Winnie and Ludwig, Friedrich-Alexander and Teodoro, Rodrigo and Sattler, Tatjana and others},
  journal={Molecules},
  volume={25},
  number={9},
  pages={2024},
  year={2020},
  publisher={Multidisciplinary Digital Publishing Institute}
}

@article{schroder2020pet,
  title={PET Imaging of the Adenosine A2A Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [18F] FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy},
  author={Schr{\"o}der, Susann and Lai, Thu Hang and Toussaint, Magali and Kranz, Mathias and Chovsepian, Alexandra and Shang, Qi and Duki{\'c}-Stefanovi{\'c}, Sladjana and Deuther-Conrad, Winnie and Teodoro, Rodrigo and Wenzel, Barbara and others},
  journal={Molecules},
  volume={25},
  number={7},
  pages={1633},
  year={2020},
  publisher={Multidisciplinary Digital Publishing Institute}
}

@article{kuttner2019quantitative,
  	title={Quantitative {PET}/{MR} imaging of lung cancer in the presence of artifacts in the {MR}-based attenuation correction maps},
  	author={Kuttner, Samuel and Lassen, Martin Lyngby and {Ø}en, Silje Kj{æ}rnes and Sundset, Rune and Beyer, Thomas and Eikenes, Live},
  	journal={Acta Radiologica},
  	pages={0284185119848118},
  	year={2019},
  	publisher={SAGE Publications Sage UK: London, England},
  	doi={10.1177/0284185119848118},
  	Pages = {1--10}}

@inbook{hansen2019catalytic,
	title={Catalytic Intermolecular Functionalization of Benzimidazoles},
  	author={Hansen, J{ø}rn H and Fjellaksel, Richard},
  	year={2019},
	booktitle={Chemistry and Applications of Benzimidazole and its Derivatives},
  	publisher={IntechOpen},
  	doi={10.5772/intechopen.87068}}

@article{fjellaksel2019evaluation,
  	title={Evaluation by metabolic profiling and in vitro autoradiography of two promising GnRH-receptor ligands for brain SPECT imaging},
  	author={Fjellaksel, Richard and Anaya, Angel Moldes and Vasskog, Terje and Oteiza, Ana and Martin-Armas, Montserrat and Hjelstuen, Ole Kristian and Hansen, J{ø}rn H and Riss, Patrick J and Sundset, Rune},
  	journal={Journal of Labelled Compounds and Radiopharmaceuticals},
  	year={2019},
  	publisher={Wiley Online Library},
  	doi={10.1002/jlcr.3820}}

@article{doi:10.1177/1545968319834904,
author = {Marte C. Ørbo and Per M. Aslaksen and Audny Anke and Pål M. Tande and Torgil R. Vangberg},
title ={Cortical Thickness and Cognitive Performance After Out-of-Hospital Cardiac Arrest},
journal = {Neurorehabilitation and Neural Repair},
volume = {33},
number = {4},
pages = {296-306},
year = {2019},
doi = {10.1177/1545968319834904}
}

@article{vangberg2019effect,
  	title={The effect of white matter hyperintensities on regional brain volumes and white matter microstructure, a population-based study in HUNT},
  	author={Vangberg, Torgil Riise and Eikenes, Live and H{å}berg, Asta K.},
  	journal={NeuroImage},
  	volume={203},
  	pages={116158},
  	year={2019},
  	publisher={Elsevier},
  	doi={10.1016/j.neuroimage.2019.116158}}

@article{castro2019white,
  	title={White matter correlates of gait perturbations resulting from spontaneous and lateralized attention in healthy older adults: A dual-task study},
  	author={Castro-Chavira, Susana A. and Vangberg, Torgil R. and Gorecka, Marta M. and Vasylenko, Olena and Waterloo, Knut and Rodr{í}guez-Aranda, Claudia},
  	journal={Experimental Gerontology},
  	volume={128},
  	pages={110744},
  	year={2019},
  	publisher={Elsevier},
  	doi={10.1016/j.exger.2019.110744}}

@article{orbo_cortical_2019,
	Author = {{Ø}rbo, Marte and Aslaksen, Per M and Anke, Audny and Tande, P{å}l Morten and Vangberg, Torgil Riise},
	Doi = {10.1177/1545968319834904},
	Journal = {Neurorehabilitation and Neural Repair},
	Number = {4},
	Pages = {296--306},
	Title = {Cortical {Thickness} and {Cognitive} {Performance} {After} {Out}-of-{Hospital} {Cardiac} {Arrest}},
	Url = {http://nnr.sagepub.com/},
	Volume = {33},
	Year = {2019},
	Bdsk-Url-1 = {http://nnr.sagepub.com/},
	Bdsk-Url-2 = {https://doi.org/10.1177/1545968319834904}}

@article{husoy_cerebral_2019,
	Author = {Hus{ø}y, Andreas Kattem and H{å}berg, Asta Kristine and Rimol, Lars Morten and Hagen, Knut and Vangberg, Torgil Riise and Stovner, Lars Jacob},
	Doi = {10.1097/j.pain.0000000000001550},
	Journal = {Pain},
	Title = {Cerebral cortical dimensions in headache sufferers aged 50-66 years: a population-based imaging study in the {Nord}-{Trondelag} {Health} {Study} ({HUNT}-{MRI})},
	Url = {http://journals.lww.com/pain/pages/default.aspx},
	Year = {2019},
	Bdsk-Url-1 = {http://journals.lww.com/pain/pages/default.aspx},
	Bdsk-Url-2 = {https://doi.org/10.1097/j.pain.0000000000001550}}

@article{hoffmann_positron_2019,
	Abstract = {Cyclone separators are widely used for separation of solids or droplets from gases or liquid fluids. They represent an elegant and robust separation technology involving low capital and maintenance costs. It is therefore interesting, to extend cyclone technology to new applications, particularly in the oil and gas industry where separation duties are becoming ever more demanding and diverse, and separation processes are moving to more remote installations, such as sub-sea or even down-hole installations. The objective of this paper is to elucidate the working of hydrocyclones including ones acting on liquids of elevated viscosity using state-of-the-art experimental and analysis techniques, namely positron emission particle tracking (PEPT) and computational fluid dynamics (CFD) with large-eddy simulation of turbulence effects. The results show a number of interesting and anomalous features of the liquid and particle flow, such as unexpected excursions of particles to the inner vortex and the effect of the vortex end on the particle flow. It is shown that it is possible to determine the axis of the hydrocyclone very precisely by a minimization technique and thus convert the output from the tracking algorithm in Cartesian coordinates to cylindrical coordinates with the cyclone as axis. This throws additional light on the results. Tracks of different particles, some of which are eventually captured and some which are lost, are shown both in 3-D Cartesian and 2-D cylindrical coordinates and the effects of the fluid and particle properties are discussed.},
	Author = {Hoffmann, Alex C. and Skorpen, {Å}shild and Chang, Yu Fen},
	Doi = {10.1016/j.ces.2019.01.061},
	Journal = {Chemical Engineering Science},
	Keywords = {CFD, Hydrocyclones, Large Eddy simulations, Liquid and particle flow, Positron emission particle tracking, Viscous liquids},
	Pages = {310--319},
	Title = {Positron emission particle tracking and {CFD} investigation of hydrocyclones acting on liquids of varying viscosity},
	Url = {http://www.sciencedirect.com/science/article/pii/S0009250919301551},
	Volume = {200},
	Year = {2019},
	Bdsk-Url-1 = {http://www.sciencedirect.com/science/article/pii/S0009250919301551}}

Cyclone separators are widely used for separation of solids or droplets from gases or liquid fluids. They represent an elegant and robust separation technology involving low capital and maintenance costs. It is therefore interesting, to extend cyclone technology to new applications, particularly in the oil and gas industry where separation duties are becoming ever more demanding and diverse, and separation processes are moving to more remote installations, such as sub-sea or even down-hole installations. The objective of this paper is to elucidate the working of hydrocyclones including ones acting on liquids of elevated viscosity using state-of-the-art experimental and analysis techniques, namely positron emission particle tracking (PEPT) and computational fluid dynamics (CFD) with large-eddy simulation of turbulence effects. The results show a number of interesting and anomalous features of the liquid and particle flow, such as unexpected excursions of particles to the inner vortex and the effect of the vortex end on the particle flow. It is shown that it is possible to determine the axis of the hydrocyclone very precisely by a minimization technique and thus convert the output from the tracking algorithm in Cartesian coordinates to cylindrical coordinates with the cyclone as axis. This throws additional light on the results. Tracks of different particles, some of which are eventually captured and some which are lost, are shown both in 3-D Cartesian and 2-D cylindrical coordinates and the effects of the fluid and particle properties are discussed.

@article{Chang_aip_2019,
	Author = {Chang,Yu Fen and Thompson,Kyle and Teymurazyan,Aram and Siciliano,Steven D. and Papandreou,Zisis},
	Doi = {10.1063/1.5114560},
	Eprint = {https://aip.scitation.org/doi/pdf/10.1063/1.5114560},
	Journal = {AIP Conference Proceedings},
	Number = {1},
	Pages = {450093},
	Title = {Numerical investigation of a transformable modular PET system: Consideration of point-spread functions, module arrangements, and operation protocols},
	Url = {https://aip.scitation.org/doi/abs/10.1063/1.5114560},
	Volume = {2116},
	Year = {2019},
	Bdsk-Url-1 = {https://aip.scitation.org/doi/abs/10.1063/1.5114560}}

@article{gevorgyan2019caesium,
  title={Caesium fluoride-mediated hydrocarboxylation of alkenes and allenes: scope and mechanistic insights},
  author={Gevorgyan, Ashot and Obst, Marc F and Guttormsen, Yngve and Maseras, Feliu and Hopmann, Kathrin H and Bayer, Annette},
  journal={Chemical science},
  volume={10},
  number={43},
  pages={10072--10078},
  year={2019},
  DOI={10.1039/C9SC02467K},
  publisher={Royal Society of Chemistry}
}

@article{doi:10.1021/acs.jmedchem.9b01006,
author = {Hansen, Kine Ø. and Andersen, Jeanette H. and Bayer, Annette and Pandey, Sunil K. and Lorentzen, Marianne and Jørgensen, Kåre B. and Sydnes, Magne O. and Guttormsen, Yngve and Baumann, Matthias and Koch, Uwe and Klebl, Bert and Eickhoff, Jan and Haug, Bengt Erik and Isaksson, Johan and Hansen, Espen H.},
title = {Kinase Chemodiversity from the Arctic: The Breitfussins},
journal = {Journal of Medicinal Chemistry},
volume = {62},
number = {22},
pages = {10167-10181},
year = {2019},
doi = {10.1021/acs.jmedchem.9b01006},
URL = {https://doi.org/10.1021/acs.jmedchem.9b01006}
}
%% --------------Yngve Guttormsen end--------------------------------------------------------
%----------------Bogsrud start----------------------------------------------------------------

@article{bogsrud201918f,
  title={18F-Fluciclovine PET/CT in suspected residual or recurrent high-grade glioma},
  author={Bogsrud, Trond V and Londalen, Ayca and Brandal, Petter and Leske, Henning and Panagopoulos, Ioannis and Borghammer, Per and Bach-Gansmo, Tore},
  journal={Clinical nuclear medicine},
  volume={44},
  number={8},
  pages={605--611},
  year={2019},
  publisher={LWW}
}

@article{moan_po-0614:_2019,
	Author = {Moan, J. M. and Malinen, E. and Svestad, J. G. and Amdal, C. D. and Bogsrud, T. V. and Dale, E.},
	Doi = {10.1016/S0167-8140(17)31051-4},
	Journal = {Radiotherapy and Oncology},
	Month = jul,
	Pages = {S320--S321},
	Title = {{PO}-0614: {The} prognostic role of 18F-{FDG} {PET}/{CT} in head and neck cancer and the importance of {HPV} status},
	Volume = {123},
	Year = {2019},
	Bdsk-Url-1 = {https://doi.org/10.1016/S0167-8140(17)31051-4}}

@article{moan_prognostic_2019,
	Abstract = {BACKGROUND AND PURPOSE: Standardized uptake value (SUV) and related parameters derived from 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) PET/CT prior to radiochemotherapy of head and neck cancer (HNC) were significantly associated with survival in a number of studies. The aim of this study was to validate these findings and to evaluate the prognostic role of PET parameters also including clinical factors and HPV status. MATERIALS AND METHODS: We reviewed 166 HNC cases with a radiotherapy planning FDG PET/CT scan. All patients received radiotherapy, 68-70Gy with or without concomitant cisplatin. Primary endpoint was disease-free survival (DFS). Twelve clinical factors, including HPV, performance status, stage and treatment parameters and ten PET/CT image parameters including gross tumor volume (GTV), metastatic lymph node volume, SUVmax, metabolic tumor volume (MTV) and total lesion glycolysis (TLG), were collected. Univariate and multivariate Cox regression analyses were employed. RESULTS: Of the 166 patients included, 48 had locoregional and 23 had metastatic recurrence. None of the FDG PET parameters were significant in the univariate analysis using DFS as endpoint. HPV status, ECOG status and GTV-U (primary tumor and lymph node volume from CT) were statistically significant (p{<}0.01). Only in the subgroup of HPV-unrelated HNC (HPV negative oropharyngeal cancer [OPC] and non-OPC; n=73), the multivariate model could be improved by including MTV (p{<}0.001). DFS events were 29 (31\%) in HPV-related and 53 (73\%) in HPV-unrelated HNC. CONCLUSION: FDG PET parameters appear less important for overall prognostication of radiochemotherapy outcome for HNC. Still, the association between the FDG PET parameters and survival is strong for HNC not related to HPV. Tumor volume from CT is generally more closely related to outcome than parameters derived from FDG PET/CT.},
	Author = {Moan, Jon Magne and Amdal, Cecilie Delphin and Malinen, Eirik and Svestad, Jorund Graadal and Bogsrud, Trond Velde and Dale, Einar},
	Copyright = {Copyright (c) 2019 Elsevier B.V. All rights reserved.},
	Doi = {10.1016/j.radonc.2019.05.019},
	Issn = {1879-0887 (Electronic); 0167-8140 (Linking)},
	Journal = {Radiotherapy and Oncology},
	Keywords = {18F-fluorodeoxyglucose, Carcinoma-squamous cell, Head and neck neoplasms, Papillomaviridae, Positron emission tomography, Proportional hazards models},
	Language = {eng},
	Month = jun,
	Pages = {54--61},
	Pmid = {31177043},
	Title = {The prognostic role of 18F-fluorodeoxyglucose {PET} in head and neck cancer depends on {HPV} status.},
	Volume = {140},
	Year = {2019},
	Bdsk-Url-1 = {https://doi.org/10.1016/j.radonc.2019.05.019}}

BACKGROUND AND PURPOSE: Standardized uptake value (SUV) and related parameters derived from 2-deoxy-2-[18F]-fluoro-d-glucose (FDG) PET/CT prior to radiochemotherapy of head and neck cancer (HNC) were significantly associated with survival in a number of studies. The aim of this study was to validate these findings and to evaluate the prognostic role of PET parameters also including clinical factors and HPV status. MATERIALS AND METHODS: We reviewed 166 HNC cases with a radiotherapy planning FDG PET/CT scan. All patients received radiotherapy, 68-70Gy with or without concomitant cisplatin. Primary endpoint was disease-free survival (DFS). Twelve clinical factors, including HPV, performance status, stage and treatment parameters and ten PET/CT image parameters including gross tumor volume (GTV), metastatic lymph node volume, SUVmax, metabolic tumor volume (MTV) and total lesion glycolysis (TLG), were collected. Univariate and multivariate Cox regression analyses were employed. RESULTS: Of the 166 patients included, 48 had locoregional and 23 had metastatic recurrence. None of the FDG PET parameters were significant in the univariate analysis using DFS as endpoint. HPV status, ECOG status and GTV-U (primary tumor and lymph node volume from CT) were statistically significant (p<0.01). Only in the subgroup of HPV-unrelated HNC (HPV negative oropharyngeal cancer [OPC] and non-OPC; n=73), the multivariate model could be improved by including MTV (p<0.001). DFS events were 29 (31%) in HPV-related and 53 (73%) in HPV-unrelated HNC. CONCLUSION: FDG PET parameters appear less important for overall prognostication of radiochemotherapy outcome for HNC. Still, the association between the FDG PET parameters and survival is strong for HNC not related to HPV. Tumor volume from CT is generally more closely related to outcome than parameters derived from FDG PET/CT.

@article{gormsen_comparative_2019,
	Author = {Gormsen, Lars Christian and Vendelbo, Mikkel Holm and Pedersen, Mette Abildgaard and Haraldsen, Ate and Hjorthaug, Karin and Bogsrud, Trond and Petersen, Lars J. and Jensen, Karen Juul and Br{ø}ndum, Rasmus and El-Galaly, Tarec C.},
	Doi = {10.1186/s13550-019-0503-z},
	Journal = {EJNMMI Research},
	Number = {36},
	Title = {A comparative study of standardized quantitative and visual assessment for predicting tumor volume and outcome in newly diagnosed diffuse large {B}-cell lymphoma staged with 18F-{FDG} {PET}/{CT}},
	Url = {http://www.ejnmmires.com/},
	Volume = {9},
	Year = {2019},
	Bdsk-Url-1 = {http://www.ejnmmires.com/},
	Bdsk-Url-2 = {https://doi.org/10.1186/s13550-019-0503-z}}

@article{calais201968ga,
  title={68Ga-PSMA-11 PET/CT detects prostate cancer at early biochemical recurrence with superior detection rate and reader agreement when compared to 18F-Fluciclovine PET/CT in a prospective head-to-head comparative phase 3 study},
  author={Calais, Jeremie and Ceci, Francesco and Eiber, Matthias and Gartmann, Jeannine and Nguyen, Kathleen and Lok, Vincent and Elashoff, David and Grogan, Tristan and Slavik, Roger and Reiter, Robert and Matthew Rettig and Hossein Jadvar and Tore Bach-Gansmo and Bital Savir-Baruch and Michael Hofman and Cristina Nanni and Christoph Rischpler and Thomas Hope11, Wolfgang Fendler and Johannes Czernin},
  journal={Journal of Nuclear Medicine},
  volume={60},
  number={supplement 1},
  pages={587--587},
  year={2019},
  publisher={Soc Nuclear Med}
}

@article{calais201918f,
  title={18F-fluciclovine PET-CT and 68Ga-PSMA-11 PET-CT in patients with early biochemical recurrence after prostatectomy: a prospective, single-centre, single-arm, comparative imaging trial},
  author={Calais, Jeremie and Ceci, Francesco and Eiber, Matthias and Hope, Thomas A and Hofman, Michael S and Rischpler, Christoph and Bach-Gansmo, Tore and Nanni, Cristina and Savir-Baruch, Bital and Elashoff, David and others},
  journal={The Lancet Oncology},
  volume={20},
  number={9},
  pages={1286--1294},
  year={2019},
  publisher={Elsevier},
  Doi={10.1016/S1470-2045(19)30415-2}
}

@article{ritawidya2019radiosynthesis,
  	title={Radiosynthesis and Biological Investigation of a Novel Fluorine-18 Labeled Benzoimidazotriazine-Based Radioligand for the Imaging of Phosphodiesterase 2A with Positron Emission Tomography},
  	author={Rien Ritawidya and Barbara Wenzel and Rodrigo Teodoro and Magali Toussaint and Mathias Kranz and Winnie Deuther-Conrad and Sladjana Dukic-Stefanovic and Friedrich-Alexander Ludwig and Matthias Scheunemann and Peter Brust},
  	journal={Molecules},
  	volume={24},
  	number={22},
  	pages={4149},
  	year={2019},
  	publisher={Multidisciplinary Digital Publishing Institute},
  	Doi = {10.3390/molecules24224149}}

@article{schroeder_investigation_2019,
	Author = {Schroeder, Susann and Lai, Thu Hang and Kranz, Mathias and Toussaint, Magali and Shang, Qi and Dukic-Stefanovic, Sladjana and Pan-Montojo, Francisco and Brust, Peter},
	Journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	Pages = {S183--S183},
	Title = {Investigation of [{F}-18] {FESCH} for {PET} imaging of the adenosine {A}2A receptor in a rotenone-based mouse model of {Parkinson}'s disease and development of a two-step one-pot radiolabeling strategy},
	Volume = {62},
	Year = {2019}}

@article{toussaint_characterization_2019,
	Author = {Toussaint, Magali and Kranz, Mathias and Schroeder, Susann and Lai, Thu Hang and Deuther-Conrad, Winnie and Dukic-Stefanovic, Sladjana and Shang, Qi and Patt, Marianne and Reichmann, Heinz and Funk, Richard},
	Journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	Pages = {S397--S398},
	Title = {Characterization of the rotenone mouse model of {Parkinson}'s disease using radioligands for the adenosine {A}2A receptor ([{F}-18] {FESCH}) and the nicotinic alpha 4 beta 2 receptor ((-)-[{F}-18] {Flubatine})},
	Volume = {62},
	Year = {2019}}

@article{ludwig_development_2019,
	Author = {Ludwig, Friedrich-Alexander and Fischer, Steffen and Moldovan, Rares and Deuther-Conrad, Winnie and Kranz, Mathias and Schepmann, Dirk and Jia, Hongmei and Wünsch, Bernhard and Brust, Peter},
	Journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	Pages = {S181--S182},
	Title = {Development of a new {F}-18-labeled radioligand for imaging sigma2 receptors by positron emission tomography},
	Volume = {62},
	Year = {2019}}

@incollection{njemanze_application_2019,
	Author = {Njemanze, Philip C and Kranz, Mathias and Brust, Peter},
	Booktitle = {Fourier {Transforms}-{Century} of {Digitalization} and {Increasing} {Expectations}},
	Doi = {10.5772/intechopen.85641},
	Publisher = {IntechOpen},
	Title = {Application of {Fourier} {Analysis} of {Cerebral} {Glucose} {Metabolism} in {Color}-{Induced} {Long}-{Term} {Potentiation}: {A} {Novel} {Functional} {PET} {Spectroscopy} ({fPETS}) {Study} in {Mice}},
	Year = {2019},
	Bdsk-Url-1 = {https://doi.org/10.5772/intechopen.85641}}

@article{ritawidya_synthesis_2019,
	Author = {Ritawidya, Rien and Teodoro, Rodrigo and Wenzel, Barbara and Kranz, Mathias and Toussaint, Magali and Dukic-Stefanovic, Sladjana and Deuther-Conrad, Winnie and Scheunemann, Matthias and Brust, Peter},
	Journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	Pages = {S162--S163},
	Title = {Synthesis and biological investigation of a novel fluorine-18 labeled benzoimidazotriazine: {A} {Potential} radioligand for in vivo phosphodiesterase 2A ({PDE}2A) {PET} imaging},
	Volume = {62},
	Year = {2019}}

@article{sadeghzadeh_development_2019,
	Author = {Sadeghzadeh, Masoud and Moldovan, Rares and Wenzel, Barbara and Kranz, Mathias and Deuther-Conrad, Winnie and Toussaint, Magali and Fischer, Steffen and Ludwig, Friedrich-Alexander and Teodoro, Rodrigo and Jonnalagadda, Sravan},
	Doi = {10.1016/j.bmc.2018.07.045},
	Journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	Pages = {S59--S60},
	Title = {Development of the first {F}-18-labeled {MCT}1/{MCT}4 lactate transport inhibitor: {Radiosynthesis} and preliminary in vivo evaluation in mice},
	Volume = {62},
	Year = {2019},
	Bdsk-Url-1 = {https://doi.org/10.1016/j.bmc.2018.07.045}}

@article{sattler_preclinical_2019,
	Author = {Sattler, Bernhard and Kranz, Mathias and Sadeghzadeh, Masoud and Wenzel, Barbara and Moldovan, Rare{ş}-Petru and Toussaint, Magali and Deuther-Conrad, Winnie and Fischer, Steffen and Ludwig, Friedrich-Alexander and Teodoro, Rodrigo},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 1},
	Pages = {1638--1638},
	Title = {Preclinical incorporation {Dosimetry} of [{F}-18] {FACH} a novel 18F-labeled {MCT}1/{MCT}4 lactate transport inhibitor},
	Volume = {60},
	Year = {2019}}

@article{schroder_entwicklung_2019,
	Author = {Schr{ö}der, S. and Lai, T. H. and Deuther-Conrad, W. and Dukic-Stefanovic, S. and Kranz, Mathias and Toussaint, M. and Shang, Q. and Pan-Montojo, F. and Brust, P.},
	Doi = {10.1055/s-0039-1683680},
	Journal = {Nuklearmedizin},
	Number = {02},
	Pages = {P85},
	Title = {Entwicklung einer {Eintopf}-{Radiosynthese} von {F}-18-{FESCH} f{ü}r die {PET}-{Bildgebung} des {Adenosin}-{A}2A-{Rezeptors} im {Rotenon}-basierten {Parkinson}-{Mausmodel}},
	Volume = {58},
	Year = {2019},
	Bdsk-Url-1 = {https://doi.org/10.1055/s-0039-1683680}}
%%---------Traasdahl, Erik R start---------------------------------------

@INPROCEEDINGS{8824574,
	author={Y. F. {Chang} and A. {Talebitaher} and K. {Thompson} and Z. {Papandreou} and A. {Teymurazyan} and S. {Siciliano}},
	booktitle={2018 IEEE Nuclear Science Symposium and Medical Imaging Conference Proceedings (NSS/MIC)},
	title={Plant-Specific Modular PET: Data Processing with CASToR and Performance Evaluation},
	year={2018},
	volume={},
	number={},
	pages={1-3},
	abstract={A modular PET detector system with variable geometry, BioPET, has been constructed to specifically study plant-microorganism-environment complexes. While the modular design in combination with rotation and translation mechanics provides greater flexibility in detector arrangement, adaptive data processing and image reconstruction methods are needed for such a transformable system. In this work, we developed a data processing pipeline by making used of a generic, modular, and extensible platform for tomography reconstruction, CASToR, and applied the process to evaluate performance of BioPET in rotational and stationary modes. The NEMA NU 4-2008 image quality phantom was utilized for analysis of recovery coefficients, spillover ratios, uniformity, and their relationship to selected reconstruction parameters. The rotational mode outperforms the stationary mode in exhibiting lower spillover effect as well as in reconstructing the activity concentration of smaller features, although partial volume effect is evidenced in both modes. The behaviour of the performance indices as a function of the selected reconstruction parameters is found specific to each detection mode. The procedure and the image quality characterization presented in this work are driving the development and optimization of data processing, image reconstruction and correction framework towards quantitative image analysis for PET systems with flexible geometry.},
	keywords={Image reconstruction;Cameras;Detectors;Image quality;Phantoms;Data processing;Positron emission tomography},
	doi={10.1109/NSSMIC.2018.8824574},
	ISSN={2577-0829}}

A modular PET detector system with variable geometry, BioPET, has been constructed to specifically study plant-microorganism-environment complexes. While the modular design in combination with rotation and translation mechanics provides greater flexibility in detector arrangement, adaptive data processing and image reconstruction methods are needed for such a transformable system. In this work, we developed a data processing pipeline by making used of a generic, modular, and extensible platform for tomography reconstruction, CASToR, and applied the process to evaluate performance of BioPET in rotational and stationary modes. The NEMA NU 4-2008 image quality phantom was utilized for analysis of recovery coefficients, spillover ratios, uniformity, and their relationship to selected reconstruction parameters. The rotational mode outperforms the stationary mode in exhibiting lower spillover effect as well as in reconstructing the activity concentration of smaller features, although partial volume effect is evidenced in both modes. The behaviour of the performance indices as a function of the selected reconstruction parameters is found specific to each detection mode. The procedure and the image quality characterization presented in this work are driving the development and optimization of data processing, image reconstruction and correction framework towards quantitative image analysis for PET systems with flexible geometry.

@article{grondahl_maskinlering_2018,
	Author = {Gr{ø}ndahl, Aurora Rosvoll and Kuttner, Samuel and Elschot, Mattijs and Bathen, Tone Frost and Sundset, Rune and Knudtsen, Ingerid Skjei and Futs{æ}ther, Cecilia Marie},
	Journal = {HMT - Helsetjenesten Medisinsk Teknikk : helse, medisin, teknikk},
	Title = {Maskinl{æ}ring og medisinske bilder for bedre diagnostikk og persontilpasset kreftbehandling},
	Url = {http://www.helsemedisinteknikk.no/},
	Volume = {5},
	Year = {2018},
	Bdsk-Url-1 = {http://www.helsemedisinteknikk.no/}}

@inproceedings{kuttner_impact_2018,
	Author = {Kuttner, Samuel and Lassen, Martin Lyngby and Kj{æ}rnes {Ø}en, Silje and Sundset, Rune and Beyer, Thomas and Eikenes, Live},
	Booktitle = {{MedFys} 2018},
	Title = {The impact of artefacts in {MR}-based attenuation correction maps on {PET}/{MR} images of lung cancer},
	Year = {2018}}

@article{fjellaksel_first_2018,
	Abstract = {In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.},
	Author = {Fjellaksel, Richard and Oteiza, Ana and Martin-Armas, Montserrat and Riss, Patrick J. and Hjelstuen, Ole Kristian and Kuttner, Samuel and Hansen, J{ø}rn Hedl{ø}y. and Sundset, Rune},
	Doi = {10.1186/s13104-018-3924-2},
	Journal = {BMC Research Notes},
	Number = {1},
	Pages = {811},
	Title = {First in vivo evaluation of a potential {SPECT} brain radiotracer for the gonadotropin releasing hormone receptor},
	Url = {https://doi.org/10.1186/s13104-018-3924-2},
	Volume = {11},
	Year = {2018},
	Bdsk-Url-1 = {https://doi.org/10.1186/s13104-018-3924-2}}

In vivo evaluations of a gonadotropin releasing hormone-receptor single photon emission computed tomography radiotracer for non-invasive detection of gonadotropin releasing homone-receptors in brain.

@article{fjellaksel_utvikling_2018,
	Author = {Fjellaksel, Richard},
	Journal = {Norsk Farmaceutisk Tidsskrift},
	Pages = {21--23},
	Title = {Utvikling og evaluering av gonadotropin frigj{ø}ringshormon antagonister som {SPECT}-radiotracere},
	Url = {http://www.farmatid.no},
	Volume = {7},
	Year = {2018},
	Bdsk-Url-1 = {http://www.farmatid.no}}

@article{fjellaksel_acylation-finkelstein_2018,
	Author = {Fjellaksel, Richard and Dugalic, Damir and Demissie, Taye Beyene and Riss, Patrick and Hjelstuen, Ole Kristian and Sundset, Rune and Hansen, J{ø}rn Hedl{ø}y},
	Doi = {10.1002/poc.3835},
	Journal = {Journal of Physical Organic Chemistry},
	Number = {7},
	Pages = {1--12},
	Title = {An acylation-{Finkelstein} approach to radioiodination of bioactives: {The} role of amide group anchimeric assistance},
	Url = {http://eu.wiley.com/WileyCDA/WileyTitle/productCd-POC.html},
	Volume = {31},
	Year = {2018},
	Bdsk-Url-1 = {http://eu.wiley.com/WileyCDA/WileyTitle/productCd-POC.html},
	Bdsk-Url-2 = {https://doi.org/10.1002/poc.3835}}

@inproceedings{fjellaksel_development_2018,
	Author = {Fjellaksel, Richard and Oteiza, Ana and Montserrat Martin-Armas and Hansen, J{ø}rn Hedl{ø}y and Moldes-Anaya, Angel and Vasskog, Terje and Hjelstuen, Ole Kristian and Riss, Patrick and Sundset, Rune},
	Booktitle = {{SNMMI}},
	Title = {Development and evaluation of gonadotropin releasing hormone {SPECT} radioligands},
	Url = {https://onlinelibrary.wiley.com/doi/full/10.1002/poc.3835},
	Year = {2018},
	Bdsk-Url-1 = {https://onlinelibrary.wiley.com/doi/full/10.1002/poc.3835}}

@article{fjellaksel_nytt_2018,
	Author = {Fjellaksel, Richard and Rustad, Eirik Andr{é}Lindel{ø}ff and Sundset, Rune and Hjelstuen, Ole Kristian},
	Journal = {Norsk Farmaceutisk Tidsskrift},
	Pages = {14--15},
	Title = {Nytt {PET}-senter i {Troms{ø}}},
	Url = {http://hdl.handle.net/10037/14656},
	Volume = {8},
	Year = {2018},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/14656}}

@article{fjellaksel_copper-mediated_2018,
	Author = {Fjellaksel, Richard and Sundset, Rune and Riss, Patrick and Hansen, J{ø}rn Hedl{ø}y},
	Doi = {10.1055/s-0036-1591985},
	Journal = {Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry},
	Number = {11},
	Pages = {1491--1495},
	Title = {Copper-mediated late-stage iodination and 123I-labelling of triazole-benzimidazole bioactives},
	Url = {http://hdl.handle.net/10037/14656},
	Volume = {29},
	Year = {2018},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/14656},
	Bdsk-Url-2 = {https://doi.org/10.1055/s-0036-1591985}}

%% ---------------Fjellaksel end---------------------------------
%% ---------------Moldes-Anaya, Angel------------------------

@article{orbo_memory_2018,
	Author = {{Ø}rbo, Marte and Vangberg, Torgil Riise and Tande, P{å}l Morten and Anke, Audny and Aslaksen, Per M},
	Doi = {10.1016/j.resuscitation.2018.02.011},
	Journal = {Resuscitation},
	Pages = {21--28},
	Title = {Memory performance, global cerebral volumes and hippocampal subfield volumes in long-term survivors of {Out}-of-{Hospital} {Cardiac} {Arrest}},
	Url = {http://www.elsevier.com/wps/product/cws_home/505959},
	Volume = {126},
	Year = {2018},
	Bdsk-Url-1 = {http://www.elsevier.com/wps/product/cws_home/505959},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.resuscitation.2018.02.011}}

@article{MYRVANG201824,
title = {Hippocampal subfields in adolescent anorexia nervosa},
journal = {Psychiatry Research: Neuroimaging},
volume = {282},
pages = {24-30},
year = {2018},
issn = {0925-4927},
doi = {10.1016/j.pscychresns.2018.10.007},
url = {https://www.sciencedirect.com/science/article/pii/S0925492718301550},
author = {Anna D. Myrvang and Torgil R. Vangberg and Kristin Stedal and Øyvind Rø and Tor Endestad and Jan H. Rosenvinge and Per M. Aslaksen},
keywords = {Anorexia Nervosa, MRI, Hippocampus, FreeSurfer, Brain segmentation},
abstract = {Patients with anorexia nervosa (AN) exhibit volume reduction in cerebral gray matter (GM), and several studies report reduced hippocampus volume. The hippocampal subfields (HS) are functionally and structurally distinct, and appear to respond differently to neuropathology. The aim of this study was to investigate HS volumes in adolescent females with restrictive AN compared to a healthy age-matched control group (HC). The FreeSurfer v6.0 package was used to extract brain volumes, and segment HS in 58 female adolescents (AN = 30, HC = 28). We investigated group differences in GM, white matter (WM), whole hippocampus and 12 HS volumes. AN patients had significantly lower total GM and total hippocampal volume. No group difference was found in WM. Volume reduction was found in 11 of the 12 HS, and most results remained significant when adjusting for global brain volume reduction. Investigations of clinical covariates revealed statistically significant relationships between the whole hippocampus, several HS and scores on depression and anxiety scales in AN. Results from this study show that young AN patients exhibit reduced volume in most subfields of the hippocampus, and that this reduction may be more extensive than the observed global cerebral volume loss.}
}

Patients with anorexia nervosa (AN) exhibit volume reduction in cerebral gray matter (GM), and several studies report reduced hippocampus volume. The hippocampal subfields (HS) are functionally and structurally distinct, and appear to respond differently to neuropathology. The aim of this study was to investigate HS volumes in adolescent females with restrictive AN compared to a healthy age-matched control group (HC). The FreeSurfer v6.0 package was used to extract brain volumes, and segment HS in 58 female adolescents (AN = 30, HC = 28). We investigated group differences in GM, white matter (WM), whole hippocampus and 12 HS volumes. AN patients had significantly lower total GM and total hippocampal volume. No group difference was found in WM. Volume reduction was found in 11 of the 12 HS, and most results remained significant when adjusting for global brain volume reduction. Investigations of clinical covariates revealed statistically significant relationships between the whole hippocampus, several HS and scores on depression and anxiety scales in AN. Results from this study show that young AN patients exhibit reduced volume in most subfields of the hippocampus, and that this reduction may be more extensive than the observed global cerebral volume loss.

@article{aslaksen_relation_2018,
	Author = {Aslaksen, Per M and Bystad, Martin Kragnes and {Ø}rbo, Marte and Vangberg, Torgil Riise},
	Doi = {10.1016/j.bbr.2018.06.008},
	Journal = {Behavioural Brain Research},
	Pages = {131--137},
	Title = {The relation of hippocampal subfield volumes to verbal episodic memory measured by the {California} {Verbal} {Learning} {Test} {II} in healthy adults},
	Url = {http://www.elsevier.com/locate/bbr},
	Volume = {351},
	Year = {2018},
	Bdsk-Url-1 = {http://www.elsevier.com/locate/bbr},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.bbr.2018.06.008}}

@inproceedings{myrvang_cortical_2018,
	Abstract = {Several studies report reduction in gray matter volume in Anorexia Nervosa, but findings regarding the relationship between brain structure and bodily emaciation are inconsistent1. In the present study, we investigated cortical thickness and its relationship with BMI in recently diagnosed female adolescents patients. We hypothesized that patients had globally thinner cortex compared to healthy controls, and that thinner cortex should be significantly associated with BMI.},
	Author = {Myrvang, Anna Dahl and Stalsberg, Vibeke and Fandrem, Stein Inge and Hansen, Torgunn Alise and Vangberg, Torgil Riise and Stedal, Kristin and R{ø}, {Ø}yvind and Endestad, Tor and Rosenvinge, Jan H and Aslaksen, Per M},
	Booktitle = {Nordic {Eating} {Disorder} {Conference}},
	Title = {Cortical thickness in adolescent anorexia nervosa --the linear relation of cerebral structural changes and {BMI}},
	Url = {http://hdl.handle.net/10037/14595},
	Year = {2018},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/14595}}

Several studies report reduction in gray matter volume in Anorexia Nervosa, but findings regarding the relationship between brain structure and bodily emaciation are inconsistent1. In the present study, we investigated cortical thickness and its relationship with BMI in recently diagnosed female adolescents patients. We hypothesized that patients had globally thinner cortex compared to healthy controls, and that thinner cortex should be significantly associated with BMI.

@inproceedings{danielsson_quantitative_2018,
	Author = {Danielsson, Lena Elsa and Kvarstein, Gunnvald and Vangberg, Torgil Riise and Bergvik, Svein and Aslaksen, Per M},
	Booktitle = {International {Association} for the {Study} of {Pain} - {World} {Congress}},
	Title = {Quantitative {Sensory} {Testing} and {Cortical} {Thickness} in {Healthy} {Volunteers}},
	Url = {http://hdl.handle.net/10037/13974},
	Year = {2018},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/13974}}

@inproceedings{roland_effekt_2018,
	Author = {Roland, Sissel Breivold and Kvarstein, Gunnvald and Aslaksen, Per M and Anke, Audny and M{\"u}ller, Kai Ivar and Vangberg, Torgil Riise},
	Booktitle = {{NOSF} {Fagkonferanse} 2018},
	Title = {Effekt av spesifikk rehabilitering ved nakkehodepine, med samtidig kartlegging av strukturelle endringer og konnektivitet i hjernen},
	Year = {2018}}

@article{chang_applying_2018,
	Abstract = {Remediation of subsurface contamination using microbial consortium can be less toxic to the environment and ecosystems than using chemical dispersants or physical measures. But bioremediation involves complex and dynamic processes in a visually opaque medium, which can be difficult to monitor. Positron emission tomography (PET), which reveals the dynamic distribution of labeled molecules, offers a means to probe into the bioremediation process. This study evaluates and verifies the feasibility of employing a freely-rearrangeable modular PET system (BioPET) in combination with a generic tomographic image reconstruction platform, CASToR, for tracking fluid transport, as well as metabolic activities, occurrence, and distribution of subsurface microorganisms. This enables quantitative imaging of bioremediation processes in high resolution with further expanding the flexible modular system and refining the data processing algorithms.},
	Author = {Chang, Yu Fen and Siciliano, Steven D. and Mamet, Steven and Conway, Alexandra J. and Schebel, Alixandra and Shannon, Whitney and Christopher, Kelly and Thompson, Kyle and Talebitaher, Alireza and Papandreou, Zisis and Teymurazyan, Aram},
	Doi = {10.1088/1742-6596/1120/1/012077},
	Journal = {Journal of Physics: Conference Series},
	Pages = {012077},
	Title = {Applying a {Modular} {PET} {System} to {Investigate} {Bioremediation} of {Subsurface} {Contamination}: {A} {Proof}-of-{Principle} {Study}},
	Url = {http://dx.doi.org/10.1088/1742-6596/1120/1/012077},
	Volume = {1120},
	Year = {2018},
	Bdsk-Url-1 = {http://dx.doi.org/10.1088/1742-6596/1120/1/012077}}

Remediation of subsurface contamination using microbial consortium can be less toxic to the environment and ecosystems than using chemical dispersants or physical measures. But bioremediation involves complex and dynamic processes in a visually opaque medium, which can be difficult to monitor. Positron emission tomography (PET), which reveals the dynamic distribution of labeled molecules, offers a means to probe into the bioremediation process. This study evaluates and verifies the feasibility of employing a freely-rearrangeable modular PET system (BioPET) in combination with a generic tomographic image reconstruction platform, CASToR, for tracking fluid transport, as well as metabolic activities, occurrence, and distribution of subsurface microorganisms. This enables quantitative imaging of bioremediation processes in high resolution with further expanding the flexible modular system and refining the data processing algorithms.

@inproceedings{siciliano_2018,
	Author = {Siciliano, Steven D. and Chang, Yu Fen and Conway, Alix J. and Shannon, Whitney and Mamet, Steven and Helgason, Bobbi and Peak, Derek and Talebitaher, Alireza and Papandreou, Zisis and Palaia, Tom and Teymurazyan, Aram},
	Booktitle = {17th {International} {Symposium} on {Microbial} {Ecology}},
	Title = {It's activity not growth: {Quantifying} milli-niches using positron emission tomography of psychrotrophic bioremediation in permafrost soils},
	Year = {2018},
	doi={10.5281/zenodo.3843253}}

@inproceedings{cite-key,
	Abstract = {This work focuses on the design of a high-resolution, Depth Of Interaction (DOI) capable PET detector module with a single-ended readout We propose the use of a several centimeters thick monolithic scintillator directly coupled to a 2D array of Silicon Photomultipliers High resolution of reconstructed energy and 3D position of gamma rays interacting with the detector is achieved through the implementation of advanced statistical reconstruction The proposed design and reconstruction algorithms have been validated using Geant4-based Monte Carlo simulations Based on these preliminary results, a small bore PET system using modules of the proposed design will have volumetric resolution of reconstructed images in the sub-millimeter range, energy resolution of ~13% and sensitivity of up to 18% Prototype modules will be constructed and tested (author)},
	Address = {Canada},
	Author = {Thompson, K. and Chang, Y. F. and Talebitaher, A. and Papandreou, Z. and Teymurazyan, A.},
	Booktitle = {The nuclear future : challenges and innovation. 38th Annual {Canadian} {Nuclear} {Society} conference},
	Isbn = {978-1-926773-27-8},
	Publisher = {Canadian Nuclear Society},
	Title = {Simulated performance of a high resolution PET detector module with depth of interaction information},
	Ty = {CONF},
	Url = {http://inis.iaea.org/search/search.aspx?orig_q=RN:50012963},
	Note = {; Available as a slide presentation also.; the Canadian Nuclear Society, Toronto, Ontario (Canada)},
	Year = {2018},
	Bdsk-Url-1 = {http://inis.iaea.org/search/search.aspx?orig_q=RN:50012963;%20Available%20as%20a%20slide%20presentation%20also.;%20the%20Canadian%20Nuclear%20Society,%20Toronto,%20Ontario%20(Canada).}}

This work focuses on the design of a high-resolution, Depth Of Interaction (DOI) capable PET detector module with a single-ended readout We propose the use of a several centimeters thick monolithic scintillator directly coupled to a 2D array of Silicon Photomultipliers High resolution of reconstructed energy and 3D position of gamma rays interacting with the detector is achieved through the implementation of advanced statistical reconstruction The proposed design and reconstruction algorithms have been validated using Geant4-based Monte Carlo simulations Based on these preliminary results, a small bore PET system using modules of the proposed design will have volumetric resolution of reconstructed images in the sub-millimeter range, energy resolution of  13% and sensitivity of up to 18% Prototype modules will be constructed and tested (author)

@inproceedings{Talebitaher:2018aa,
	Abstract = {The Nuclear Imaging Detector Development group at the Department of Physics, University of Regina is developing Canada's first positron emission tomography (PET) system for plant physiological function studies In its current configuration the system consists of four detectors heads, each with active area of 48x48 mm2 In a typical arrangement the four detectors are grouped in two pairs of opposing heads for detecting coincident events from positron annihilation, however the system geometry, data acquisition and image reconstruction are flexible and can be easily reconfigured on-demand to accommodate other scanner configurations The detector pairs can be scanned along the vertical axis allowing to image plants up to 50 cm tall, while the plant within the Field of View (FOV) of the scanner can be rotated on a precision controlled motorized platform to provide a complete 3D coverage of the plant Current development and characterization of the plant PET system will be presented (author)},
	Address = {Canada},
	Author = {Talebitaher, A. and Chang, Y. F. and Thompson, K. and Papandreou, Z. and Mamet, S. and Siciliano, S. D. and Lee, S. J. and McKisson, J. E. and Kross, B. and Teymurazyan, A.},
	Booktitle = {The nuclear future : challenges and innovation. 38th Annual {Canadian} {Nuclear} {Society} conference},
	Isbn = {978-1-926773-27-8},
	Publisher = {Canadian Nuclear Society},
	Title = {BioPET: dedicated plant and soil micro-organism positron emission tomography system},
	Ty = {CONF},
	Url = {http://inis.iaea.org/search/search.aspx?orig_q=RN:50012905},
	Note = {the Canadian Nuclear Society, Toronto, Ontario (Canada)},
	Year = {2018},
	doi={10.5281/zenodo.3842961},
	Bdsk-Url-1 = {http://inis.iaea.org/search/search.aspx?orig_q=RN:50012905;%20the%20Canadian%20Nuclear%20Society,%20Toronto,%20Ontario%20(Canada).}}

The Nuclear Imaging Detector Development group at the Department of Physics, University of Regina is developing Canada's first positron emission tomography (PET) system for plant physiological function studies In its current configuration the system consists of four detectors heads, each with active area of 48x48 mm2 In a typical arrangement the four detectors are grouped in two pairs of opposing heads for detecting coincident events from positron annihilation, however the system geometry, data acquisition and image reconstruction are flexible and can be easily reconfigured on-demand to accommodate other scanner configurations The detector pairs can be scanned along the vertical axis allowing to image plants up to 50 cm tall, while the plant within the Field of View (FOV) of the scanner can be rotated on a precision controlled motorized platform to provide a complete 3D coverage of the plant Current development and characterization of the plant PET system will be presented (author)

@inproceedings{teymurazyan_development_2018,
	Author = {Teymurazyan, Aram and Talebitaher, AAlireza and Chang, Yu Fen and Papandreou, Zisis and Yost, Christopher K.},
	Booktitle = {24th {North} {American} {Symbiotic} {Nitrogen} {Fixation} {Conference}},
	Title = {Development of a positron emission tomography ({PET}) detector ({BioPET}) for imaging and quantifying nutrient exchange between crop plants and {N}2 fixing bacteria},
	Year = {2018}}

@article{berntsen_pfos-induced_2018,
	Author = {Berntsen, Hanne Friis and Bj{ø}rklund, Cesilie Granum and Strandab{ø}, R{ø}nnaug and Haug, Trude and Moldes-Anaya, Angel and Fuentes-Lazaro, Judit and Verhaegen, Steven and Paulsen, Ragnhild Elisabeth and Tasker, R. Andrew and Ropstad, Erik},
	Doi = {10.1016/j.taap.2018.08.015},
	Journal = {Toxicology and Applied Pharmacology},
	Pages = {19--32},
	Title = {{PFOS}-induced excitotoxicity is dependent on {Ca}2+ influx via {NMDA} receptors in rat cerebellar granule neurons},
	Url = {http://www.academicpress.com/tap},
	Volume = {357},
	Year = {2018},
	Bdsk-Url-1 = {http://www.academicpress.com/tap},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.taap.2018.08.015}}

@article{eide_serum_2018,
	Author = {Eide, Hanne Astrid and Knudtsen, Ingerid Skjei and Sandhu, Vandana and L{ø}ndalen, Ayca and Halvorsen, Ann Rita and Abravan, Azadeh and Kure, Elin Wenche Hegland and Bogsrud, Trond and Brustugun, Odd Terje and Kyte, Jon A and Malinen, Eirik and Helland, {Å}slaug},
	Doi = {10.1016/j.adro.2017.12.007},
	Journal = {Advances in Radiation Oncology},
	Number = {2},
	Pages = {130--138},
	Title = {Serum cytokine profiles and metabolic tumor burden in patients with non-small cell lung cancer undergoing palliative thoracic radiation therapy},
	Url = {http://www.advancesradonc.org/},
	Volume = {3},
	Year = {2018},
	Bdsk-Url-1 = {http://www.advancesradonc.org/},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.adro.2017.12.007}}

@article{munthe_fdg-based_2018,
	Author = {Munthe, Else and Riss, Patrick and Saga, T. and Haraldsen, Ira Hebold and Grad, Iwona and Bogsrud, Trond and Bach-Gansmo, Tore},
	Doi = {10.1111/cpf.12378},
	Journal = {Clinical Physiology and Functional Imaging},
	Number = {1},
	Pages = {34--37},
	Title = {{FDG}-based quantitative comparison of glucose metabolism in vitro, exemplified by a head-to-head comparison between a triple-negative breast cancer cell line and a non-malignant foetal cell line},
	Url = {http://hdl.handle.net/11250/2561013},
	Volume = {38},
	Year = {2018},
	Bdsk-Url-1 = {http://hdl.handle.net/11250/2561013},
	Bdsk-Url-2 = {https://doi.org/10.1111/cpf.12378}}

@article{skjotskift_dose_2018,
	Author = {Skj{ø}tskift, Torleiv and Evensen, Morten Egeberg and Furre, Torbj{ø}rn and Moan, Jon Magne Kaarstein and Amdal, Cecilie Delphin and Bogsrud, Trond and Malinen, Eirik and Dale, Einar},
	Doi = {10.1080/0284186X.2018.1512753},
	Journal = {Acta Oncologica},
	Number = {12},
	Pages = {1693--1699},
	Title = {Dose painting for re-irradiation of head and neck cancer},
	Url = {http://informahealthcare.com/journal/onc},
	Volume = {57},
	Year = {2018},
	Bdsk-Url-1 = {http://informahealthcare.com/journal/onc},
	Bdsk-Url-2 = {https://doi.org/10.1080/0284186X.2018.1512753}}

@article{blakkisrud2018biodistribution,
  title={Biodistribution and dosimetry results from a phase 1 trial of therapy with the antibody--radionuclide conjugate 177lu-lilotomab satetraxetan},
  author={Blakkisrud, Johan and Holtedahl, Jon Erik and L{ø}ndalen, Ayca and Dahle, Jostein and Bach-Gansmo, Tore and Holte, Harald and Nygaard, Stine and Kolstad, Arne and Stokke, Caroline},
  journal={Journal of Nuclear Medicine},
  volume={59},
  number={4},
  pages={704--710},
  year={2018},
  publisher={Soc Nuclear Med},
  doi={10.2967/jnumed.117.195347}
}

@article{lindemann2018radiosynthesis,
  title={Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for PET imaging of the adenosine A2B receptor},
  author={Lindemann, Marcel and Hinz, Sonja and Deuther-Conrad, Winnie and Namasivayam, Vigneshwaran and Dukic-Stefanovic, Sladjana and Teodoro, Rodrigo and Toussaint, Magali and Kranz, Mathias and Juhl, Cathleen and Steinbach, Joerg and others},
  journal={Bioorganic \& medicinal chemistry},
  volume={26},
  number={16},
  pages={4650--4663},
  year={2018},
  publisher={Elsevier},
  Doi={10.1016/j.bmc.2018.07.045}
}

@article{kranz_bridging_2018,
	Author = {Kranz, Mathias and Bergmann, Ralf and Kniess, Torsten and Belter, Birgit and Neuber, Christin and Cai, Zhengxin and Deng, Gang and Fischer, Steffen and Zhou, Jiangbing and Huang, Yiyun},
	Doi = {10.3390/molecules23030702},
	Journal = {Molecules},
	Number = {3},
	Pages = {702},
	Title = {Bridging from {Brain} to {Tumor} {Imaging}:({S})-(−)-and ({R})-(+)-[18F] {Fluspidine} for {Investigation} of {Sigma}-1 {Receptors} in {Tumor}-{Bearing} {Mice}},
	Volume = {23},
	Year = {2018},
	Bdsk-Url-1 = {https://doi.org/10.3390/molecules23030702}}

@article{kranz_monte-carlo_2018,
	Author = {Kranz, Mathias and Sattler, Bernhard and Desbree, Aurelie and Rullmann, Michael and Deuther-Conrad, Winnie and Steinbach, Joerg and Brust, Peter and Sabri, Osama},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 1},
	Pages = {475--475},
	Title = {Monte-{Carlo} ({MC}) simulation and calculation of the specific absorbed fractions ({SAFs}) of radiation energy for internal dosimetry using a {VOXEL} phantom of a piglet},
	Volume = {59},
	Year = {2018}}

@article{lindemann_radiosynthesis_2018,
	Author = {Lindemann, Marcel and Hinz, Sonja and Deuther-Conrad, Winnie and Namasivayam, Vigneshwaran and Dukic-Stefanovic, Sladjana and Teodoro, Rodrigo and Toussaint, Magali and Kranz, Mathias and Juhl, Cathleen and Steinbach, Joerg},
	Journal = {Bioorganic \& medicinal chemistry},
	Number = {16},
	Pages = {4650--4663},
	Title = {Radiosynthesis and in vivo evaluation of a fluorine-18 labeled pyrazine based radioligand for {PET} imaging of the adenosine {A}2B receptor},
	Volume = {26},
	Year = {2018}}

@article{njemanze_fourier_2018,
	Author = {Njemanze, Philip and Kranz, Mathias and Brust, Peter},
	Doi = {10.3390/forecast1010010},
	Journal = {Forecasting},
	Number = {1},
	Pages = {135--156},
	Title = {Fourier {Analysis} of {Cerebral} {Metabolism} of {Glucose}: {Gender} {Differences} in {Mechanisms} of {Color} {Processing} in the {Ventral} and {Dorsal} {Streams} in {Mice}},
	Volume = {1},
	Year = {2018},
	Bdsk-Url-1 = {https://doi.org/10.3390/forecast1010010}}

@article{schroder_investigation_2018,
	Author = {Schr{ö}der, Susann and Wenzel, Barbara and Deuther-Conrad, Winnie and Teodoro, Rodrigo and Kranz, Mathias and Scheunemann, Matthias and Egerland, Ute and H{ö}fgen, Norbert and Briel, Detlef and Steinbach, J{ö}rg},
	Doi = {10.3390/molecules23030556},
	Journal = {Molecules},
	Number = {3},
	Pages = {556},
	Title = {Investigation of an 18F-labelled {Imidazopyridotriazine} for {Molecular} {Imaging} of {Cyclic} {Nucleotide} {Phosphodiesterase} 2A},
	Volume = {23},
	Year = {2018},
	Bdsk-Url-1 = {https://doi.org/10.3390/molecules23030556}}

@article{dietrichs_effects_2018,
	Author = {Dietrichs, Erik Sveberg and H{Å}heim, Brage and Kondratyev, Timofey and Traasdahl, Erik R. and Tveita, Torkjel},
	Doi = {10.1152/japplphysiol.00317.2017},
	Journal = {Journal of applied physiology},
	Number = {4},
	Pages = {850--859},
	Title = {Effects of hypothermia and rewarming on cardiovascular autonomic control in vivo},
	Url = {http://jap.physiology.org/},
	Volume = {124},
	Year = {2018},
	Bdsk-Url-1 = {http://jap.physiology.org/},
	Bdsk-Url-2 = {https://doi.org/10.1152/japplphysiol.00317.2017}}

@inproceedings{fjellaksel_development_2017,
	Author = {Fjellaksel, Richard},
	Booktitle = {{Troms{ø}PET} seminar},
	Title = {Development and evaluation of gonadotropin releasing hormone ({GnRH}) radioligands},
	Year = {2017}}

@article{fjellaksel_small_2017,
	Author = {Fjellaksel, Richard and Boomgaren, Marc and Sundset, Rune and Haraldsen, Ira Hebold and Hansen, J{ø}rn Hedl{ø}y and Riss, Patrick},
	Doi = {10.1039/c7md00320j},
	Journal = {MedChemComm},
	Number = {10},
	Pages = {1965--1969},
	Title = {Small molecule piperazinyl-benzimidazole antagonists of the gonadotropin-releasing hormone ({GnRH}) receptor},
	Url = {http://www.rsc.org/Publishing/Journals/MD/about.asp},
	Volume = {8},
	Year = {2017},
	Bdsk-Url-1 = {http://www.rsc.org/Publishing/Journals/MD/about.asp},
	Bdsk-Url-2 = {https://doi.org/10.1039/c7md00320j}}

@inproceedings{fjellaksel_development_2017-1,
	Author = {Fjellaksel, Richard and Hansen, J{ø}rn Hedl{ø}y and Moldes-Anaya, Angel and Montserrat Martin-Armas and Oteiza, Ana and Riss, Patrick and Sundset, Rune},
	Booktitle = {{EANM} 17},
	Title = {Development and evaluation of gonadotropin releasing hormone ({GnRH}) {SPECT} radioligands},
	Year = {2017}}

@inproceedings{arild_prospective_2017,
	Author = {Arild, Anette and Stensvold, Dorthe and Vangberg, Torgil Riise and H{å}berg, Asta K.},
	Booktitle = {The 5th {National} {PhD} {Conference} in {Neuroscience}},
	Title = {A prospective study of white matter hyper intensities in the "{Generation} 100" mental abilities and {MRI} cohort study},
	Year = {2017}}

@inproceedings{arild_prospective_2017-1,
	Author = {Arild, Anette and Stensvold, Dorthe and Vangberg, Torgil Riise and H{å}berg, Asta K.},
	Booktitle = {Frampeik},
	Title = {A prospective study of white matter hyperintensities in the "{Generation} 100" mental abilities and {MRI} cohort study},
	Year = {2017}}

@inproceedings{castro_chavira_association_2017,
	Abstract = {English Association of white matter integrity and gait speed during dual-tasking among community-dwelling elderly adults},
	Author = {Castro Chavira, Susana Angelica and Vangberg, Torgil Riise and Gorecka, Marta Maria and Vasylenko, Olena and Waterloo, Knut and Rodriguez-Aranda, Claudia},
	Booktitle = {Society for {Neuroscience} {Annual} {Meeting} 2017},
	Title = {Association of white matter integrity and gait speed during dual-tasking among community-dwelling elderly adults. [{Poster}]},
	Url = {https://www.sfn.org/-/media/SfN/Documents/Annual-Meeting/FinalProgram/NS2017/Full-Abstract-PDFs-2017/SFN17_Abstract-PDFs—Posters_1_Sat_PM.ashx?la=en&hash=E9E09C09D48B422701DC59791D92DEDDC89C76F4},
	Year = {2017},
	Bdsk-Url-1 = {https://www.sfn.org/-/media/SfN/Documents/Annual-Meeting/FinalProgram/NS2017/Full-Abstract-PDFs-2017/SFN17_Abstract-PDFs%E2%80%94Posters_1_Sat_PM.ashx?la=en&hash=E9E09C09D48B422701DC59791D92DEDDC89C76F4}}

English Association of white matter integrity and gait speed during dual-tasking among community-dwelling elderly adults

@article{balakin_non-invasive_2017,
	Author = {Balakin, B. V. and Adamsen, T. C. H. and Chang, Y. F. and Kosinski, P. and Hoffmann, A. C.},
	Journal = {Journal of Physics: Conference Series},
	Number = {1},
	Pages = {012039},
	Title = {Non-invasive studies of multiphase flow in process equipment. {Positron} emission particle tracking technique},
	Url = {http://stacks.iop.org/1742-6596/781/i=1/a=012039},
	Volume = {781},
	Year = {2017},
	Doi = {10.1088/1742- 6596/781/1/012039},
	Bdsk-Url-1 = {http://stacks.iop.org/1742-6596/781/i=1/a=012039}}

@inproceedings{chang_visualising_2017,
	Author = {Chang, Yu Fen},
	Booktitle = {Impact {Week}},
	Publisher = {Greater Stavanger},
	Title = {Visualising multiphase flow in process equipment and biological structure using {PEPT}},
	Year = {2017}}

@inproceedings{haugland_intrahippocampal_2017,
	Author = {Haugland, Kamilla Gjerland and Moldes-Anaya, Angel and Olberg, Anniken and Lande, Andreas and Kjelstrup, Kirsten Brun and Brun, Vegard},
	Booktitle = {5th {National} {PhD} {Conference} in {Neuroscience}},
	Title = {Intrahippocampal growth hormone modulates spatial memory},
	Year = {2017}}

@article{berntsen_fungal_2017,
	Abstract = {Penitrem A is a fungal neurotoxin that recurrently causes intoxication in animals, and occasionally also in humans. We have previously reported that penitrem A induced the production of reactive oxygen species (ROS) in rat cerebellar granule cells, opening for a new mechanism of action for the neurotoxin. The aim of this study was to examine the potential of penitrem A to induce ROS production in isolated human neutrophil granulocytes, and to study possible mechanisms involved. Penitrem A significantly increased the production of ROS in human neutrophils at concentrations as low as 0.25μM (40\% increase over basal levels), as measured with the DCF fluorescence assay. The EC50 determined for the production of ROS by penitrem A was 3.8μM. The maximal increase in ROS production was approximately 330\% over basal levels at a concentration of 12.5μM. ROS formation was significantly inhibited by the antioxidant vitamin E (50μM), the intracellular Ca+2 chelator BAPTA-AM (5μM), the mitogen activated protein kinase kinase (MEK) 1/2 and 5 inhibitor U0126 (1 and 10μM), the p38 mitogen activated protein kinase (MAPK) inhibitor SB203580 (1μM), the c-Jun amino-terminal kinase (JNK) inhibitor SP600125 (10μM), and the calcineurin inhibitors FK-506 and cyclosporine A (1.5 and 0.5μM, respectively). These finding suggest that penitrem A is able to induce an increase in ROS production in neutrophils via the activation of several MAPK-signalling pathways. We suggest that this increase may partly explain the pathophysiology generated by penitrem A neuromycotoxicosis in both humans and animals.},
	Author = {Berntsen, H. F. and Bogen, I. L. and Wigestrand, M. B. and Fonnum, F. and Walaas, S. I. and Moldes-Anaya, A.},
	Doi = {10.1016/j.tox.2017.10.008},
	Journal = {Toxicology},
	Keywords = {Neuromycotoxicosis, Neutrophil granulocytes, Penitrem A, Reactive oxygen species (ROS)},
	Pages = {64--70},
	Title = {The fungal neurotoxin penitrem {A} induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations},
	Url = {http://www.sciencedirect.com/science/article/pii/S0300483X17303141},
	Volume = {392},
	Year = {2017},
	Bdsk-Url-1 = {http://www.sciencedirect.com/science/article/pii/S0300483X17303141},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.tox.2017.10.008}}

Penitrem A is a fungal neurotoxin that recurrently causes intoxication in animals, and occasionally also in humans. We have previously reported that penitrem A induced the production of reactive oxygen species (ROS) in rat cerebellar granule cells, opening for a new mechanism of action for the neurotoxin. The aim of this study was to examine the potential of penitrem A to induce ROS production in isolated human neutrophil granulocytes, and to study possible mechanisms involved. Penitrem A significantly increased the production of ROS in human neutrophils at concentrations as low as 0.25μM (40% increase over basal levels), as measured with the DCF fluorescence assay. The EC50 determined for the production of ROS by penitrem A was 3.8μM. The maximal increase in ROS production was approximately 330% over basal levels at a concentration of 12.5μM. ROS formation was significantly inhibited by the antioxidant vitamin E (50μM), the intracellular Ca+2 chelator BAPTA-AM (5μM), the mitogen activated protein kinase kinase (MEK) 1/2 and 5 inhibitor U0126 (1 and 10μM), the p38 mitogen activated protein kinase (MAPK) inhibitor SB203580 (1μM), the c-Jun amino-terminal kinase (JNK) inhibitor SP600125 (10μM), and the calcineurin inhibitors FK-506 and cyclosporine A (1.5 and 0.5μM, respectively). These finding suggest that penitrem A is able to induce an increase in ROS production in neutrophils via the activation of several MAPK-signalling pathways. We suggest that this increase may partly explain the pathophysiology generated by penitrem A neuromycotoxicosis in both humans and animals.

@article{aastrom_interplay_2017,
	Author = {{Å}str{ö}m, Pirjo and Juurikka, Krista and Hadler-Olsen, Elin S. and Svineng, Gunbj{ø}rg and Cervigne, Nilva K. and Coletta, Ricardo D. and Risteli, Juha and Kauppila, Joonas H. and Skarp, Sini and Kuttner, Samuel and Oteiza, Ana and Sutinen, Meeri and Salo, Tuula},
	Doi = {10.1038/bjc.2017.249},
	Journal = {British Journal Of Cancer},
	Pages = {1007 EP --},
	Title = {The interplay of matrix metalloproteinase-8, transforming growth factor-β1 and vascular endothelial growth factor-{C} cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma},
	Url = {https://doi.org/10.1038/bjc.2017.249},
	Volume = {117},
	Year = {2017},
	Bdsk-Url-1 = {https://doi.org/10.1038/bjc.2017.249}}

@article{bach-gansmo_multisite_2017,
	Author = {Bach-Gansmo, Tore and Nanni, Cristina and Nieh, Peter T. and Zanoni, Lucia and Bogsrud, Trond and Sletten, Heidi and Korsan, Katrine Andersen and Kieboom, Jasper and Tade, Funmilayo I. and Odewole, Oluwaseun and Chau, Albert and Ward, Penelope and Goodman, Mark M. and Fanti, Stefano and Schuster, David M. and Willoch, Frode},
	Doi = {10.1016/j.juro.2016.09.117},
	Journal = {Journal of Urology},
	Number = {3},
	Pages = {676--683},
	Title = {Multisite experience of the safety, detection rate and diagnostic performance of fluciclovine (18F) positron emission tomography/computerized tomography imaging in the staging of biochemically recurrent prostate cancer},
	Volume = {197},
	Year = {2017},
	Bdsk-Url-1 = {https://doi.org/10.1016/j.juro.2016.09.117}}

@inproceedings{haugland_intrahippocampal_2017-1,
	Author = {Kamilla Gjerland Haugland and Angel Moldes-Anaya and Anniken Olberg and Andreas Lande and Kirsten Brun Kjelstrup and Vegard Brun},
	Booktitle = {5th {National} {PhD} {Conference} in {Neuroscience}},
	Title = {Intrahippocampal growth hormone modulates spatial memory},
	Year = {2017}}

@inproceedings{knudtsen_18fdg_pet_ct_2017,
	Author = {Knudtsen, Ingerid S{ø}berg Skjei and Eide, Hanne Astrid and L{ø}ndalen, Ayca and Abravan, Azadeh and Bogsrud, Trond and Sprauten, Mette and Brustugun, Odd Terje and Helland, {Å}slaug and Malinen, Eirik},
	Booktitle = {{NACP}2017},
	Title = {18FDG-{PET}/{CT} for assessing short-term therapy response of advanced non-small cell lung cancer patients},
	Year = {2017}}

@inproceedings{mao_using_2017,
	Author = {Mao, Hong and {Ø}ie, Cristina Ionica and Li, Ruomei and Oteiza, Ana and S{ø}rensen, Karen Kristine and Wolfson, Deanna and Ahluwalia, Balpreet Singh and Cogger, Victoria Carroll and Le Couteur, David George and McCourt, Peter Anthony},
	Booktitle = {Australian {Biology} of {Ageing} {Conference}},
	Title = {Using super-resolution microscopy to image disruption of liver sinusoidal endothelial cell morphology by oxidized low-density lipoproteins},
	Url = {https://doi.org/10.1007/s00259-017-3822-1},
	Note = {Eur J Nucl Med Mol Imaging (2017) 44(Suppl 2): 119},
	Year = {2017},
	Bdsk-Url-1 = {Eur%20J%20Nucl%20Med%20Mol%20Imaging%20(2017)%2044(Suppl%202):%20119.%20https://doi.org/10.1007/s00259-017-3822-1}}

@inproceedings{mao_disruption_2017,
	Author = {Mao, Hong and {Ø}ie, Cristina Ionica and Li, Ruomei and Oteiza, Ana and S{ø}rensen, Karen Kristine and Wolfson, Deanna and Huser, Thomas Rolf and Ahluwalia, Balpreet Singh and Cogger, Victoria Carroll and Le Couteur, David George and McCourt, Peter Anthony},
	Booktitle = {19th {International} {Symposium} on {Cells} of the {Hepatic} {Sinusoid}},
	Title = {Disruption of rat liver sinusoidal endothelial cell morphology by oxidised low density lipoproteins},
	Year = {2017}}

@inproceedings{moldes-anaya_targetting_2017,
	Author = {Moldes-Anaya, Angel and Ragazzi, Lorenzo and Kuttner, Samuel and Vincenz, Daniel and Goldschmidt, J{ü}rgen and Brun, Vegard and Kjelstrup, Kirsten Brun},
	Booktitle = {1st {Troms{ø}} {PET} seminar},
	Title = {Targetting mnemonic pathways of stress by cerebral perfusion using 99mTc-{HMPAO} {SPECT}/{CT}},
	Year = {2017}}

@article{moldes-anaya_two_2017,
	Abstract = {The peroxisome proliferator-activated receptors (PPARs) function as ligand-activated transcription factors that convert signals in the form of lipids to physiological responses through the activation of metabolic target genes. Due to their key roles in lipid and carbohydrate metabolism, the PPARs are important drug targets. However, for several of the PPAR drugs currently in use, adverse side effects have been reported. In an effort to identify compounds from marine organisms that may serve as molecular scaffolds for the development of novel and safer PPAR-targeting drugs, we performed a bioassay-guided screening of organic extracts made from organisms supplied by the Norwegian Biobank of Arctic Marine Organisms (Marbank). Among several interesting hits, we identified two poorly described isomeric oxo-fatty acids from the microalgae Chaetoceros karianus for which we provide the first evidence that they might display dual specificity towards human PPARαand PPARγ. Principal component analysis showed that C. karianus stood out from other Chaetoceros species, both with respect to the metabolic profile and the PPAR activity. The isolation of these compounds holds the potential of uncovering a PPAR pharmacophore with tunable activity and specificity. Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ},
	Author = {Moldes-Anaya, Angel and S{æ}ther, Thomas and Uhlig, Silvio and Nebb, Hilde Irene and Larsen, Terje and Eilertsen, Hans Christian and Paulsen, Steinar Martin},
	Doi = {10.3390/md15060148},
	Journal = {Marine Drugs},
	Number = {148},
	Pages = {16},
	Title = {Two {Isomeric} {C}16 {Oxo}-{Fatty} {Acids} from the {Diatom} {Chaetoceros} karianus {Show} {Dual} {Agonist} {Activity} towards {Human} {Peroxisome} {Proliferator}-{Activated} {Receptors} ({PPARs}) α/γ},
	Url = {http://www.mdpi.com/journal/marinedrugs},
	Volume = {15},
	Year = {2017},
	Bdsk-Url-1 = {http://www.mdpi.com/journal/marinedrugs},
	Bdsk-Url-2 = {https://doi.org/10.3390/md15060148}}

The peroxisome proliferator-activated receptors (PPARs) function as ligand-activated transcription factors that convert signals in the form of lipids to physiological responses through the activation of metabolic target genes. Due to their key roles in lipid and carbohydrate metabolism, the PPARs are important drug targets. However, for several of the PPAR drugs currently in use, adverse side effects have been reported. In an effort to identify compounds from marine organisms that may serve as molecular scaffolds for the development of novel and safer PPAR-targeting drugs, we performed a bioassay-guided screening of organic extracts made from organisms supplied by the Norwegian Biobank of Arctic Marine Organisms (Marbank). Among several interesting hits, we identified two poorly described isomeric oxo-fatty acids from the microalgae Chaetoceros karianus for which we provide the first evidence that they might display dual specificity towards human PPARαand PPARγ. Principal component analysis showed that C. karianus stood out from other Chaetoceros species, both with respect to the metabolic profile and the PPAR activity. The isolation of these compounds holds the potential of uncovering a PPAR pharmacophore with tunable activity and specificity. Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ

@article{munk_point-spread_2017,
	Author = {Munk, Ole Lajord and Tolbod, Lars P. and Hansen, S{ø}ren Baarsgaard and Bogsrud, Trond},
	Doi = {10.1186/s40658-016-0169-9},
	Journal = {EJNMMI Physics},
	Pages = {1--12},
	Title = {Point-spread function reconstructed {PET} images of sub-centimeter lesions are not quantitative},
	Url = {http://ejnmmiphys.springeropen.com/},
	Volume = {4:5},
	Year = {2017},
	Bdsk-Url-1 = {http://ejnmmiphys.springeropen.com/},
	Bdsk-Url-2 = {https://doi.org/10.1186/s40658-016-0169-9}}

@article{blakkisrud2017tumor,
  title={Tumor-absorbed dose for non-Hodgkin lymphoma patients treated with the anti-CD37 antibody radionuclide conjugate 177Lu-lilotomab satetraxetan},
  author={Blakkisrud, Johan and L{ø}ndalen, Ayca and Martinsen, Anne CT and Dahle, Jostein and Holtedahl, Jon E and Bach-Gansmo, Tore and Holte, Harald and Kolstad, Arne and Stokke, Caroline},
  journal={Journal of Nuclear Medicine},
  volume={58},
  number={1},
  pages={48--54},
  year={2017},
  publisher={Soc Nuclear Med},
  doi={10.2967/jnumed.116.173922}
}

@article{lindemann2017spiroindolines,
  title={Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?},
  author={Lindemann, Marcel and Deuther-Conrad, Winnie and Moldovan, Rares and Sekhar, Kondapalli Venkata Gowri Chandra and Brust, Peter and Wenzel, Barbara},
  journal={Bioorganic \& medicinal chemistry},
  volume={25},
  number={19},
  pages={5107--5113},
  year={2017},
  publisher={Elsevier},
  Doi={10.1016/j.bmc.2017.03.028}
}
%---------------Marcel end-------------------------------------
%% ---------------Montse start---------------------

@article{hankir_gastric_2017,
	Author = {Hankir, Mohammed K and Seyfried, Florian and Hintschich, Constantin A and Diep, Thi-Ai and Kleberg, Karen and Kranz, Mathias and Deuther-Conrad, Winnie and Tellez, Luis A and Rullmann, Michael and Patt, Marianne},
	Doi = {10.1016/j.cmet.2016.12.006},
	Journal = {Cell metabolism},
	Number = {2},
	Pages = {335--344},
	Title = {Gastric bypass surgery recruits a gut {PPAR}-α-striatal {D}1R pathway to reduce fat appetite in obese rats},
	Volume = {25},
	Year = {2017},
	Bdsk-Url-1 = {https://doi.org/10.1016/j.cmet.2016.12.006}}

@article{hankir_suppressed_2017,
	Author = {Hankir, Mohammed K and Patt, Marianne and Patt, J{ö}rg TW and Becker, Georg A and Rullmann, Michael and Kranz, Mathias and Deuther-Conrad, Winnie and Schischke, Kristin and Seyfried, Florian and Brust, Peter},
	Doi = {10.3389/fnins.2016.00620},
	Journal = {Frontiers in Neuroscience},
	Pages = {620},
	Title = {Suppressed fat appetite after {Roux}-en-{Y} gastric bypass surgery associates with reduced brain μ-opioid receptor availability in diet-induced obese male rats},
	Volume = {10},
	Year = {2017},
	Bdsk-Url-1 = {https://doi.org/10.3389/fnins.2016.00620}}

@article{hankir_dissociation_2017,
	Author = {Hankir, Mohammed K and Kranz, Mathias and Keipert, Susanne and Weiner, Juliane and Andreasen, Sille G and Kern, Matthias and Patt, Marianne and Kl{ö}ting, Nora and Heiker, John T and Brust, Peter},
	Doi = {10.2967/jnumed.116.186460},
	Journal = {Journal of Nuclear Medicine},
	Number = {7},
	Pages = {1100--1103},
	Title = {Dissociation {Between} {Brown} {Adipose} {Tissue} 18F-{FDG} {Uptake} and {Thermogenesis} in {Uncoupling} {Protein} 1--{Deficient} {Mice}},
	Volume = {58},
	Year = {2017},
	Bdsk-Url-1 = {https://doi.org/10.2967/jnumed.116.186460}}

@article{njemanze_gender_2017,
	Author = {Njemanze, Philip C and Kranz, Mathias and Amend, Mario and Hauser, Jens and Wehrl, Hans and Brust, Peter},
	Journal = {PloS One},
	Number = {7},
	Pages = {e0179919},
	Title = {Gender differences in cerebral metabolism for color processing in mice: {A} {PET}/{MRI} {Study}},
	Volume = {12},
	Year = {2017}}

@article{wagner_radiosynthesis_2017,
	Author = {Wagner, Sally and Teodoro, Rodrigo and Deuther‐Conrad, Winnie and Kranz, Mathias and Scheunemann, Matthias and Fischer, Steffen and Wenzel, Barbara and Egerland, Ute and Hoefgen, Norbert and Steinbach, J{ö}rg},
	Doi = {10.1002/jlcr.3471},
	Journal = {Journal of Labelled Compounds and Radiopharmaceuticals},
	Number = {1},
	Pages = {36--48},
	Title = {Radiosynthesis and biological evaluation of the new {PDE}10A radioligand [18F] {AQ}28A},
	Volume = {60},
	Year = {2017},
	Bdsk-Url-1 = {https://doi.org/10.1002/jlcr.3471}}

@inproceedings{dugalic_development_2016,
	Author = {Dugalic, Damir and Fjellaksel, Richard and Boomgaren, Marc and Hjelstuen, Ole Kristian and Hansen, J{ø}rn Hedl{ø}y},
	Booktitle = {31st {Organic} {Chemistry} {Winter} {Meeting}},
	Title = {Development and validation of gonadotropin releasing hormone receptor {SPECT}/{PET} radioligands},
	Year = {2016}}

@article{backer-grondahl_new_2016,
	Author = {Backer-Gr{ø}ndahl, Anders and Lindal, Sigurd and Lorentzen, Merethe Andberg and Eldevik, Petter and Vorren, Torgrim and Kristiansen, Bente and Vangberg, Torgil R. and Ytreb{ø}, Lars Marius},
	Doi = {10.1177/0023677215619806},
	Journal = {Laboratory Animals},
	Number = {5},
	Pages = {379--389},
	Title = {A new non-craniotomy model of subarachnoid hemorrhage in the pig: a pilot study},
	Volume = {50},
	Year = {2016},
	Bdsk-Url-1 = {https://doi.org/10.1177/0023677215619806}}

@inproceedings{myrvang_reduced_2016,
	Author = {Myrvang, Anna Dahl and Vangberg, Torgil Riise and Stedal, Kristin and R{ø}, {Ø}yvind and Endestad, Tor and Fandrem, Stein Inge and Stalsberg, Vibeke and Aslaksen, Per M},
	Booktitle = {Organization of {Human} {Brain} {Mapping} {Annual} meeting 2016},
	Title = {Reduced functional connectivity in resting state networks in adolescents with anorexia nervosa},
	Year = {2016}}

@article{rodriguez-aranda_neuroanatomical_2016,
	Author = {Rodriguez-Aranda, Claudia and Waterloo, Knut and Johnsen, Stein Harald and Eldevik, Odd Petter and Sparr, Sigurd and Wikran, Gry Charlotte and Herder, Marit and Vangberg, Torgil Riise},
	Doi = {10.1016/j.bandl.2016.03.001},
	Journal = {Brain and Language},
	Pages = {24--35},
	Title = {Neuroanatomical correlates of verbal fluency in early {Alzheimer}'s disease and normal aging},
	Url = {http://www.journals.elsevier.com/brain-and-language},
	Volume = {155-156},
	Year = {2016},
	Bdsk-Url-1 = {http://www.journals.elsevier.com/brain-and-language},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.bandl.2016.03.001}}

@article{rogne_magnetic_2016,
	Author = {Rogne, Sigbj{ø}rn Olav and Vangberg, Torgil Riise and Eldevik, Odd Petter and Wikran, Gry Charlotte and Mathiesen, Ellisiv B. and Schirmer, Henrik},
	Doi = {10.1159/000450885},
	Journal = {Dementia and geriatric cognitive disorders extra},
	Number = {3},
	Pages = {529--540},
	Title = {Magnetic resonance volumetry: prediction of subjective memory complaints and mild cognitive impairment, and associations with genetic and cardiovascular risk factors},
	Url = {http://www.karger.com/Journal/Home/254733},
	Volume = {6},
	Year = {2016},
	Bdsk-Url-1 = {http://www.karger.com/Journal/Home/254733},
	Bdsk-Url-2 = {https://doi.org/10.1159/000450885}}

@article{rogne2016magnetic,
  title={Magnetic resonance volumetry: prediction of subjective memory complaints and mild cognitive impairment, and associations with genetic and cardiovascular risk factors},
  author={Rogne, Sigbj{\o}rn and Vangberg, Torgil and Eldevik, Petter and Wikran, Gry and Mathiesen, Ellisiv B and Schirmer, Henrik},
  journal={Dementia and geriatric cognitive disorders extra},
  volume={6},
  number={3},
  pages={529--540},
  year={2016},
  publisher={Karger Publishers},
  doi={10.1159/000450885}
}

@phdthesis{chang_study_2016,
	Author = {Chang, Yu Fen},
	School = {The University of Bergen},
	Title = {Study of the flow in a hydrocyclone using positron emission particle tracking and computational fluid dynamics simulation},
	Type = {{PhD} {Thesis}},
	Year = {2016}}

@inproceedings{sether_anti-diabetic_2016,
	Author = {S{ë}ther, Thomas and Moldes-Anaya, Angel and Tungen, J{ø}rn Eivind and Vik, Anders and Paulsen, Steinar M and Sylte, Ingebrigt and Hansen, Trond Vidar and Nebb, Hilde Irene},
	Booktitle = {Throne {Holst} {Symposium}},
	Title = {Anti-diabetic activity from marine lipids: new anti-diabetic drugs},
	Year = {2016}}

@article{blix_ascending_2016,
	Author = {Blix, Arnoldus S and Kuttner, Samuel and Messelt, Edvard Berger},
	Doi = {10.1152/ajpregu.00070.2016},
	Journal = {American Journal of Physiology. Regulatory Integrative and Comparative Physiology},
	Number = {1},
	Pages = {R144--R149},
	Title = {Ascending aorta of hooded seals with particular emphasis on its vasa vasorum},
	Url = {http://ajpregu.physiology.org/},
	Volume = {311},
	Year = {2016},
	Bdsk-Url-1 = {http://ajpregu.physiology.org/},
	Bdsk-Url-2 = {https://doi.org/10.1152/ajpregu.00070.2016}}

@article{dale_cervical_2016,
	Author = {Dale, Einar and Moan, Jon Magne and Osnes, Terje and Bogsrud, Trond},
	Doi = {10.1007/s00405-016-4318-5},
	Journal = {European Archives of Oto-Rhino-Laryngology},
	Number = {2},
	Pages = {1015--1019},
	Title = {Cervical lymph node metastases of squamous cell carcinoma of unknown origin: the diagnostic value of {FDG} {PET}/{CT} and clinical outcome},
	Url = {http://www.springeronline.com/sgw/cda/frontpage/0,11855,5-10076-70-1064799-0,00.html},
	Volume = {274},
	Year = {2016},
	Bdsk-Url-1 = {http://www.springeronline.com/sgw/cda/frontpage/0,11855,5-10076-70-1064799-0,00.html},
	Bdsk-Url-2 = {https://doi.org/10.1007/s00405-016-4318-5}}

@article{fa_este_biotransformation_2016,
	Author = {F{æ}ste, Christiane Kruse and Moldes-Anaya, Angel},
	Doi = {10.1016/j.toxicon.2016.11.003},
	Journal = {Toxicon},
	Pages = {36--43},
	Title = {Biotransformation of the fungal neurotoxin {Thomitrem} {A} by primary rat hepatocytes},
	Url = {http://hdl.handle.net/10037/11756},
	Volume = {124},
	Year = {2016},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/11756},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.toxicon.2016.11.003}}

@inproceedings{haugland_intrahippocampal_2016,
	Author = {Haugland, Kamilla Gjerland and Moldes-Anaya, Angel and Kjelstrup, Kirsten Brun and Brun, Vegard},
	Booktitle = {Society for {Neuroscience}},
	Title = {Intrahippocampal growth hormone modulates spatial memory},
	Year = {2016}}

@inproceedings{hjelstuen_production_2016,
	Author = {Hjelstuen, Ole Kristian},
	Booktitle = {Nuclear {Medicine} - {PET} seminar},
	Title = {Production, {Development} and {UiT} {Collaborations}},
	Year = {2016}}

@article{horsager_optimal_2016,
	Author = {Horsager, Jacob and Bak-Fredslund, Kirstine and Larsen, Lars Peter and Villadsen, Gerda Elisabeth and Bogsrud, Trond and S{ø}rensen, Michael},
	Doi = {10.1186/s13550-016-0206-7},
	Journal = {EJNMMI Research},
	Pages = {1--7},
	Title = {Optimal 2-[18F]fluoro-2-deoxy-d-galactose {PET}/{CT} protocol for detection of hepatocellular carcinoma},
	Url = {http://www.ejnmmires.com/},
	Volume = {6:56},
	Year = {2016},
	Bdsk-Url-1 = {http://www.ejnmmires.com/},
	Bdsk-Url-2 = {https://doi.org/10.1186/s13550-016-0206-7}}

@inproceedings{kristoffersen_diverse_2016,
	Author = {Kristoffersen, Tone and Samuelsen, Eline and Buhire, Phenias and Ramstad, Lisa and Molden, Ane and Demissie, Taye Beyene and Hansen, J{ø}rn Hedl{ø}y},
	Booktitle = {31st {Organic} {Chemistry} {Winter} {Meeting}},
	Title = {Diverse libraries for chemoprospecting and chemical education},
	Year = {2016}}

@inproceedings{mao_disruption_2016,
	Author = {Mao, Hong and {Ø}ie, Cristina Ionica and Li, Ruomei and Oteiza, Ana and S{ø}rensen, Karen Kristine and Wolfson, Deanna and Ahluwalia, Balpreet Singh and McCourt, Peter Anthony},
	Booktitle = {International {Conference} on {Nanoscopy} 2016},
	Title = {Disruption of liver sinusoidal endothelial cell morphology by oxidized low--density lipoproteins},
	Year = {2016}}

@inproceedings{mccourt_identification_2016,
	Author = {McCourt, Peter Anthony and Oteiza, Ana and Storan, Melonie J. and Williams, Brenda and Heazlewood, Chad K. and S{ø}rensen, Karen Kristine and Nefzger, Christian and Kubota, Y. and Polo, Jose and Nilsson, Susie},
	Booktitle = {The 52nd {Norwegian} {Biochemical} {Society} ({NBS}) {Contact} {Meeting}; 2016-01-21 - 2016-01-23},
	Title = {Identification of adult hemogenic sinusoidal endothelial cells in adult bone marrow},
	Year = {2016}}

@inproceedings{ragazzi_contextual_2016,
	Author = {Ragazzi, Lorenzo and Moldes-Anaya, Angel and Brun, Vegard and Kjelstrup, Kirsten Brun},
	Booktitle = {Society for {Neuroscience} 2016},
	Title = {Contextual fear encoded by hippocampal single units},
	Year = {2016}}

@inproceedings{sa_ether_anti-diabetic_2016,
	Author = {S{æ}ther, Thomas and Moldes-Anaya, Angel and Tungen, J{ø}rn Eivind and Vik, Anders and Paulsen, Steinar M and Sylte, Ingebrigt and Hansen, Trond Vidar and Nebb, Hilde Irene},
	Booktitle = {Throne {Holst} {Symposium}},
	Title = {Anti-diabetic activity from marine lipids: new anti-diabetic drugs},
	Year = {2016}}

@article{zaharieva_loss--function_2016,
	Author = {Zaharieva, Irena and Thor, Michael G and Oates, Emily and Karnebeek, Clara and Hendson, Glenda and Blom, Eveline and Witting, Nanna and Rasmussen, Magnhild and Gabbett, Michael and Ravenscroft, Gianina and Sframeli, Maria and Suetterlin, Karen and Sarkozy, Anna and D'Argenzio, Luigi and Hartley, Louise and Matthews, Emma and Pitt, Matthew and Vissing, John and Ballegaard, Martin and Krarup, Christian and Sl{ø}rdahl, Andreas and Halvorsen, Hanne and Cyntia Ye, Xin and Zhang, Lin-Hua and L{ø}kken, Nicoline and Werlauff, Ulla and Abdelsayed, Mena and Davis, Mark R and Feng, Lucy and Phadke, Rahul and Sewry, Caroline A and Morgan, Jennifer and Laing, Nigel G. and Vallance, Hilary and Ruben, Peter and Hanna, Michael G and Lewis, Suzanne and Kamsteeg, Erik-Jan and M{ä}nnikk{ö}, Roope and Muntoni, Francesco},
	Doi = {10.1093/brain/awv352},
	Journal = {Brain},
	Number = {3},
	Pages = {674--691},
	Title = {Loss-of-function mutations in {SCN}4A cause severe foetal hypokinesia or 'classical' congenital myopathy},
	Url = {http://www.brain.oupjournals.org/},
	Volume = {139},
	Year = {2016},
	Bdsk-Url-1 = {http://www.brain.oupjournals.org/},
	Bdsk-Url-2 = {https://doi.org/10.1093/brain/awv352}}

%-----------------Tore Bach-Gansmo without Trond-------------------------------------

@article{schulz2016diagnostic,
  title={Diagnostic performance of CT, MRI and PET/CT in patients with suspected colorectal liver metastases: the superiority of MRI},
  author={Schulz, Anselm and Viktil, Ellen and Godt, Johannes Clemens and Johansen, Cathrine K and Dormagen, Johann Baptist and Holtedahl, Jon Erik and Labori, Knut J{ø}rgen and Bach-Gansmo, Tore and Kl{ø}w, Nils-Einar},
  journal={Acta radiologica},
  volume={57},
  number={9},
  pages={1040--1048},
  year={2016},
  publisher={SAGE Publications Sage UK: London, England},
  doi={10.1177/0284185115617349}
}

@inproceedings{kolstad2016pre,
  title={Pre-dosing with unlabelled antibody significantly increases the pharmacokinetic exposure but protects against myelosuppression of 177lu-lilotomab in non-hodgkin b-cell lymphoma patients},
  author={Kolstad, A and Madsbu, U and Stokke, C and Bach-Gansmo, T and Londalen, A Muftuler and Holtedahl, JE and Revheim, ME and Bruland, O and Dahle, J and Curtis, L Baylor and others},
  booktitle={HAEMATOLOGICA},
  volume={101},
  pages={482--482},
  year={2016},
  organization={FERRATA STORTI FOUNDATION VIA GIUSEPPE BELLI 4, 27100 PAVIA, ITALY}
}

@article{bach2016myocardial,
  title={Myocardial uptake of bone scintigraphic agents associated with increased pulmonary uptake},
  author={Bach-Gansmo, Tore and Wien, Tale N and L{ø}ndalen, Ayca and Halvorsen, Erling},
  journal={Clinical physiology and functional imaging},
  volume={36},
  number={3},
  pages={237--241},
  year={2016},
  publisher={Wiley Online Library}
}
%---------------Bach-Gansmo, Tore without trond end-----------------------
%---------------Marcel start-------------------------------------

@article{hankir_novel_2016,
	Author = {Hankir, Mohammed K and Kranz, Mathias and Gnad, Thorsten and Weiner, Juliane and Wagner, Sally and Deuther‐Conrad, Winnie and Bronisch, Felix and Steinhoff, Karen and Luthardt, Julia and Kl{ö}ting, Nora},
	Doi = {10.15252/emmm.201506085},
	Journal = {EMBO Molecular Medicine},
	Number = {7},
	Pages = {796--812},
	Title = {A novel thermoregulatory role for {PDE}10A in mouse and human adipocytes},
	Volume = {8},
	Year = {2016},
	Bdsk-Url-1 = {https://doi.org/10.15252/emmm.201506085}}

@article{kranz_radiation_2016,
	Author = {Kranz, Mathias and Sattler, Bernhard and Tiepolt, Solveig and Wilke, Stephan and Deuther-Conrad, Winnie and Donat, Cornelius K and Fischer, Steffen and Patt, Marianne and Schildan, Andreas and Patt, J{ö}rg and Ren{é} Smits and Alexander Hoepping and J{ö}rg Steinbach and Osama Sabri and Peter Brust},
	Doi = {10.1186/s40658-016-0160-5},
	Journal = {EJNMMI Physics},
	Number = {1},
	Pages = {25},
	Title = {Radiation dosimetry of the α4 β2 nicotinic receptor ligand (+)-[18 {F}]flubatine, comparing preclinical {PET}/{MRI} and {PET}/{CT} to first-in-human {PET}/{CT} results},
	Volume = {3},
	Year = {2016},
	Bdsk-Url-1 = {https://doi.org/10.1186/s40658-016-0160-5}}

@article{kranz_gender_2016,
	Author = {Kranz, Mathias and Njemanze, Philip and Brust, Peter},
	Doi = {10.1371/journal.pone.0179919},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 2},
	Pages = {1333--1333},
	Title = {Gender differences in color processing in mice as revealed with functional {PET}},
	Volume = {57},
	Year = {2016},
	Bdsk-Url-1 = {https://doi.org/10.1371/journal.pone.0179919}}

@article{kranz_evaluation_2016,
	Author = {Kranz, Mathias and Sattler, Bernhard and W{ü}st, Nathanael and Deuther-Conrad, Winnie and Patt, Marianne and Meyer, Philipp and Fischer, Steffen and Donat, Cornelius and W{ü}nsch, Bernhard and Hesse, Swen},
	Journal = {Molecules},
	Number = {9},
	Pages = {1164},
	Title = {Evaluation of the enantiomer specific biokinetics and radiation doses of [18F] fluspidine---{A} new tracer in clinical translation for imaging of σ1 receptors},
	Volume = {21},
	Year = {2016}}

@article{kranz_preclinical_2016,
	Author = {Kranz, Mathias and Hankir, Mohammed and Deuther-Conrad, Winnie and Wagner, Sally and Teodoro, Rodrigo and Wenzel, Barbara and Fenske, Wiebke and Brust, Peter},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 2},
	Pages = {405--405},
	Title = {Preclinical {PET}/{MR}: {Defining} novel roles for phosphodiesterase 10A in brain and brown adipose tissue ({BAT}) in the regulation of energy homeostasis},
	Volume = {57},
	Year = {2016}}

@article{moldovan_development_2016,
	Author = {Moldovan, Rare{ş}-Petru and Teodoro, Rodrigo and Gao, Yongjun and Deuther-Conrad, Winnie and Kranz, Mathias and Wang, Yuchuan and Kuwabara, Hiroto and Nakano, Masayoshi and Valentine, Heather and Fischer, Steffen},
	Journal = {Journal of medicinal chemistry},
	Number = {17},
	Pages = {7840--7855},
	Title = {Development of a high-affinity {PET} radioligand for imaging cannabinoid subtype 2 receptor},
	Volume = {59},
	Year = {2016}}

@article{sattler_first--man_2016,
	Author = {Sattler, Bernhard and Kranz, Mathias and Wuest, Nathanael and Patt, Marianne and Meyer, Philipp and Deuther-Conrad, Winnie and Fischer, Steffen and Wuensch, Bernhard and Brust, Peter and Sabri, Osama},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 2},
	Pages = {1022--1022},
	Title = {First-in-man incorporation dosimetry of ({S})-(-)-[18F] fluspidine},
	Volume = {57},
	Year = {2016}}

@article{weiner_thyroid_2016,
	Author = {Weiner, Juliane and Kranz, Mathias and Kl{ö}ting, Nora and Kunath, Anne and Steinhoff, Karen and Rijntjes, Eddy and K{ö}hrle, Josef and Zeisig, Vilia and Hankir, Mohammed and Gebhardt, Claudia and Winnie Deuther-Conrad and John T. Heiker and Susan Kralisch and Michael Stumvoll and Matthias Bl{ü}her and Osama Sabri and Swen Hesse and Peter Brust and Anke T{ö}njes and Kerstin Krause},
	Doi = {10.1038/srep38124},
	Journal = {Scientific reports},
	Pages = {38124},
	Title = {Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice},
	Volume = {6},
	Year = {2016},
	Bdsk-Url-1 = {https://doi.org/10.1038/srep38124}}

@article{wenzel_development_2016,
	Author = {Wenzel, Barbara and Mollitor, Jan and Deuther-Conrad, Winnie and Dukic-Stefanovic, Sladjana and Kranz, Mathias and Vraka, Chrysoula and Teodoro, Rodrigo and G{ü}nther, Robert and Donat, Cornelius K and Ludwig, Friedrich-Alexander and Steffen Fischer and Rene Smits and Wolfgang Wadsak and Markus Mitterhauser and J{ö}rg Steinbach and Alexander Hoepping and Peter Brust},
	Doi = {10.1021/acs.jmedchem.5b01080},
	Journal = {Journal of medicinal chemistry},
	Number = {5},
	Pages = {1800--1817},
	Title = {Development of a novel nonpeptidic 18F-labeled radiotracer for in vivo imaging of oxytocin receptors with positron emission tomography},
	Volume = {59},
	Year = {2016},
	Bdsk-Url-1 = {https://doi.org/10.1021/acs.jmedchem.5b01080}}

@article{norum2016health,
  title={Health economics and Radium-223 (Xofigo({R})) in the treatment of metastatic Castration-Resistant Prostate Cancer (mCRPC): A case history and a systematic review of the literature},
  author={Norum, Jan and Traasdahl, Erik R and Totth, Arpad and Nieder, Carsten and Olsen, Jan Abel},
  journal={Global journal of health science},
  volume={8},
  number={4},
  pages={1},
  year={2016},
  publisher={Canadian Center of Science and Education}
}

@article{norum_pet-ct_2015,
	Author = {Norum, Jan and S{ø}ndergaard, Ursula and Traasdahl, Erik R. and Nieder, Carsten and Toll{å}li, Geir and Andersen, Gry and Sundset, Rune},
	Doi = {10.1186/s12880-015-0073-0},
	Journal = {BMC Medical Imaging},
	Number = {36},
	Pages = {8},
	Title = {{PET}-{CT} in the sub-arctic region of {Norway} 2010-2013. {At} the edge of what is possible?},
	Url = {http://www.biomedcentral.com/bmcmedimaging/},
	Volume = {15},
	Year = {2015},
	Bdsk-Url-1 = {http://www.biomedcentral.com/bmcmedimaging/},
	Bdsk-Url-2 = {https://doi.org/10.1186/s12880-015-0073-0}}

@inproceedings{acquarone_comparing_2015,
	Author = {Acquarone, Mario and Biuw, Martin and Nord{ø}y, Erling Sverre and Aoki, K. and Schotts, P and Johansen, KA and Weum, Sven and Sundset, Rune and Folkow, Lars},
	Booktitle = {21st {Biennial} {Conference} on the {Biology} of {Marine} {Mammals}},
	Title = {Comparing gross body composition of harp seals from computed tomography, isotope dilution and dissection},
	Year = {2015}}

%%----------------Sundset-----------------------------------
%% ---------------Fjellaksel---------------------------------

@inproceedings{fjellaksel_new_2015,
	Author = {Fjellaksel, Richard and Boomgaren, Marc and Hansen, J{ø}rn Hedl{ø}y and Sundset, Rune},
	Booktitle = {Norwegian {Society} for {Nuclear} {Medicine} and {Medical} {Imaging} {Spring} {Meeting}},
	Title = {New {Diagnosis} for {Alzheimer}'s {Disease}},
	Year = {2015}}

@article{fjellaksel_ny_2015,
	Author = {Fjellaksel, Richard and Hjelstuen, Ole Kristian and Sundset, Rune},
	Journal = {Dagavisen Nordlys},
	Title = {Ny diagnostikk for {Alzheimers} i {Nytt} {Senter}},
	Url = {http://hdl.handle.net/10037/7891},
	Year = {2015},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/7891}}

@article{hansen_how_2015,
	Author = {Hansen, Tor Ivar and Brezova, Veronika and Eikenes, Live and H{å}berg, Asta K. and Vangberg, Torgil Riise},
	Doi = {10.3174/ajnr.A4299},
	Journal = {American Journal of Neuroradiology},
	Number = {8},
	Pages = {1450--1456},
	Title = {How {Does} the {Accuracy} of {Intracranial} {Volume} {Measurements} {Affect} {Normalized} {Brain} {Volumes}? {Sample} {Size} {Estimates} {Based} on 966 {Subjects} from the {HUNT} {MRI} {Cohort}},
	Url = {http://hdl.handle.net/10037/10573},
	Volume = {36},
	Year = {2015},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/10573},
	Bdsk-Url-2 = {https://doi.org/10.3174/ajnr.A4299}}

@article{orbo_relevance_2015,
	Author = {{Ø}rbo, Marte Christine and Aslaksen, Per M and Larsby, Kristina and Sch{\"a}fer, Christoph and Tande, P{å}l Morten and Vangberg, Torgil Riise and Anke, Audny},
	Doi = {10.2340/16501977-1998},
	Journal = {Journal of Rehabilitation Medicine},
	Number = {9},
	Pages = {860--866},
	Title = {Relevance of cognition to health-related quality of life in good-outcome survivors of out-of-hospital cardiac arrest},
	Url = {http://www.medicaljournals.se/jrm/},
	Volume = {47},
	Year = {2015},
	Bdsk-Url-1 = {http://www.medicaljournals.se/jrm/},
	Bdsk-Url-2 = {https://doi.org/10.2340/16501977-1998}}

@article {Hansen1450,
	author = {Hansen, T.I. and Brezova, V. and Eikenes, L. and Håberg, A. and Vangberg, T.R.},
	title = {How Does the Accuracy of Intracranial Volume Measurements Affect Normalized Brain Volumes? Sample Size Estimates Based on 966 Subjects from the HUNT MRI Cohort},
	volume = {36},
	number = {8},
	pages = {1450--1456},
	year = {2015},
	doi = {10.3174/ajnr.A4299},
	publisher = {American Journal of Neuroradiology},
	abstract = {BACKGROUND AND PURPOSE: The intracranial volume is commonly used for correcting regional brain volume measurements for variations in head size. Accurate intracranial volume measurements are important because errors will be propagated to the corrected regional brain volume measurements, possibly leading to biased data or decreased power. Our aims were to describe a fully automatic SPM-based method for estimating the intracranial volume and to explore the practical implications of different methods for obtaining the intracranial volume and normalization methods on statistical power.MATERIALS AND METHODS: We describe a method for calculating the intracranial volume that can use either T1-weighted or both T1- and T2-weighted MR images. The accuracy of the method was compared with manual measurements and automatic estimates by FreeSurfer and SPM-based methods. Sample size calculations on intracranial volume{\textendash}corrected regional brain volumes with intracranial volume estimates from FreeSurfer, SPM, and our proposed method were used to explore the benefits of accurate intracranial volume estimates.RESULTS: The proposed method for estimating the intracranial volume compared favorably with the other methods evaluated here, with mean and absolute differences in manual measurements of -0.1\% and 2.2\%, respectively, and an intraclass correlation coefficient of 0.97 when using T1-weighted images. Using both T1- and T2-weighted images for estimating the intracranial volume slightly improved the accuracy. Sample size calculations showed that both the accuracy of intracranial volume estimates and the method for correcting the regional volume measurements affected the sample size.CONCLUSIONS: Accurate intracranial volume estimates are most important for ratio-corrected regional brain volumes, for which our proposed method can provide increased power in intracranial volume{\textendash}corrected regional brain volume data.ARBMautomatic reverse brain maskHUNTNord-Tr{\o}ndelag Health StudyICCintraclass correlation coefficientICVintracranial volumeRBMreverse brain maskSPMStatistical Parameteric Mapping},
	issn = {0195-6108},
	URL = {http://www.ajnr.org/content/36/8/1450},
	journal = {American Journal of Neuroradiology}
}

BACKGROUND AND PURPOSE: The intracranial volume is commonly used for correcting regional brain volume measurements for variations in head size. Accurate intracranial volume measurements are important because errors will be propagated to the corrected regional brain volume measurements, possibly leading to biased data or decreased power. Our aims were to describe a fully automatic SPM-based method for estimating the intracranial volume and to explore the practical implications of different methods for obtaining the intracranial volume and normalization methods on statistical power.MATERIALS AND METHODS: We describe a method for calculating the intracranial volume that can use either T1-weighted or both T1- and T2-weighted MR images. The accuracy of the method was compared with manual measurements and automatic estimates by FreeSurfer and SPM-based methods. Sample size calculations on intracranial volume–corrected regional brain volumes with intracranial volume estimates from FreeSurfer, SPM, and our proposed method were used to explore the benefits of accurate intracranial volume estimates.RESULTS: The proposed method for estimating the intracranial volume compared favorably with the other methods evaluated here, with mean and absolute differences in manual measurements of -0.1% and 2.2%, respectively, and an intraclass correlation coefficient of 0.97 when using T1-weighted images. Using both T1- and T2-weighted images for estimating the intracranial volume slightly improved the accuracy. Sample size calculations showed that both the accuracy of intracranial volume estimates and the method for correcting the regional volume measurements affected the sample size.CONCLUSIONS: Accurate intracranial volume estimates are most important for ratio-corrected regional brain volumes, for which our proposed method can provide increased power in intracranial volume–corrected regional brain volume data.ARBMautomatic reverse brain maskHUNTNord-Trøndelag Health StudyICCintraclass correlation coefficientICVintracranial volumeRBMreverse brain maskSPMStatistical Parameteric Mapping

@article{chang_lagrangian_2015,
	Abstract = {In this study, the liquid flow in a reverse-flow hydrocyclone is studied experimentally using the Lagrangian approach. Resin beads with densities that are close to the density of the liquid in which they move, i.e., neutral-density particles, are used to model a fluid element in the highly turbulent flow in a hydrocyclone separator and tracked using PEPT with a temporal resolution of up to 0.5 ms. A method of producing neutral-density particles for PEPT was developed. The data processing algorithm was improved for the extra challenging tracking conditions that were encountered. The components of velocity, which reveal the detailed velocity field of the fluid, were calculated from the positions of the tracers. Various noise-removal methods, again to cope with the challenging tracking conditions, were applied and discussed.},
	Author = {Chang, Yu Fen and Hoffmann, Alex C.},
	Doi = {10.1007/s00348-014-1875-5},
	Journal = {Experiments in Fluids},
	Number = {1},
	Pages = {4},
	Title = {A {Lagrangian} study of liquid flow in a reverse-flow hydrocyclone using positron emission particle tracking},
	Url = {https://doi.org/10.1007/s00348-014-1875-5},
	Volume = {56},
	Year = {2015},
	Bdsk-Url-1 = {https://doi.org/10.1007/s00348-014-1875-5}}

In this study, the liquid flow in a reverse-flow hydrocyclone is studied experimentally using the Lagrangian approach. Resin beads with densities that are close to the density of the liquid in which they move, i.e., neutral-density particles, are used to model a fluid element in the highly turbulent flow in a hydrocyclone separator and tracked using PEPT with a temporal resolution of up to 0.5 ms. A method of producing neutral-density particles for PEPT was developed. The data processing algorithm was improved for the extra challenging tracking conditions that were encountered. The components of velocity, which reveal the detailed velocity field of the fluid, were calculated from the positions of the tracers. Various noise-removal methods, again to cope with the challenging tracking conditions, were applied and discussed.

@mastersthesis{mortensen_competitive_2015,
	Author = {Mortensen, {Å}se-Karen},
	School = {Norwegian University of Science and Technology},
	Title = {Competitive binding of persistent organic pollutants to the thyroid hormone transport protein transthyretin in {Glaucous} gull ({Larus} hypoerboreus)},
	Url = {http://hdl.handle.net/10037/9123},
	Year = {2015},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/9123}}

@inproceedings{sether_anti-diabetic_2015,
	Author = {S{ë}ther, Thomas and Moldes-Anaya, Angel and Tungen, J{ø}rn Eivind and Vik, Anders and Paulsen, Steinar Martin and Sylte, Ingebrigt and Hansen, Trond Vidar and Nebb, Hilde Irene},
	Booktitle = {{EMBO} {Conference} on {Nuclear} {Receptors}},
	Title = {Anti-diabetic activity from marine lipids: new anti-diabetic drugs},
	Url = {http://hdl.handle.net/10037/9085},
	Year = {2015},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/9085}}

@article{ahluwalia_squeezing_2015,
	Author = {Ahluwalia, Balpreet Singh and McCourt, Peter Anthony and Oteiza, Ana and Wilkinson, James S. and Huser, Thomas Rolf and Helles{ø}, Olav Gaute},
	Doi = {10.1039/c4an01181c},
	Journal = {The Analyst},
	Number = {1},
	Pages = {223--229},
	Title = {Squeezing red blood cells on an optical waveguide to monitor cell deformability during blood storage},
	Url = {http://www.rsc.org/is/journals/current/analyst/anlpub.htm},
	Volume = {140},
	Year = {2015},
	Bdsk-Url-1 = {http://www.rsc.org/is/journals/current/analyst/anlpub.htm},
	Bdsk-Url-2 = {https://doi.org/10.1039/c4an01181c}}

@article{cao_role_2015,
	Author = {Cao, Huimin and Heazlewood, Shen Y. and Williams, Brenda and Cardozo, Daniela and Nigro, Julie and Oteiza, Ana and Nilsson, Susan K.},
	Doi = {10.3324/haematol.2015.135921},
	Journal = {Haematologica},
	Number = {1},
	Pages = {26--37},
	Title = {The role of {CD}44 in fetal and adult hematopoietic stem cell regulation},
	Url = {http://www.haematologica.it/index.html},
	Volume = {101},
	Year = {2015},
	Bdsk-Url-1 = {http://www.haematologica.it/index.html},
	Bdsk-Url-2 = {https://doi.org/10.3324/haematol.2015.135921}}

@inproceedings{haugland_role_2015,
	Author = {Haugland, Kamilla Gjerland and Moldes-Anaya, Angel and Kjelstrup, Kirsten Brun and Brun, Vegard},
	Booktitle = {1st. {Nordic} {Neuroscience} {Meeting}},
	Title = {The role of intrahippocampal growth hormone in spatial memory},
	Year = {2015}}

@inproceedings{haugland_role_2015-1,
	Author = {Haugland, KG and Moldes-Anaya, Angel and Kjelstrup, Kirsten Brun and Brun, Vegard},
	Booktitle = {3rd {National} {PhD} {Conference} in {Neuroscience}},
	Title = {The role of intrahippocampal {Growth} hormone in spatial memmory},
	Year = {2015}}

@article{kolstad_sequential_2015,
	Author = {Kolstad, Arne and Kumari, Shraddha and Walczak, Mateusz and Madsbu, Ulf Erik and Hagtvedt, Trond and Bogsrud, Trond and Kvalheim, Gunnar and Holte, Harald and Aurlien, Ellen and Delabie, Jan and Tierens, Anne and Olweus, Johanna},
	Doi = {10.1182/blood-2014-07-592162},
	Journal = {Blood},
	Number = {1},
	Pages = {82--89},
	Title = {Sequential intranodal immunotherapy induces antitumor immunity and correlated regression of disseminated follicular lymphoma},
	Url = {http://www.bloodjournal.org/misc/about.shtml},
	Volume = {125},
	Year = {2015},
	Bdsk-Url-1 = {http://www.bloodjournal.org/misc/about.shtml},
	Bdsk-Url-2 = {https://doi.org/10.1182/blood-2014-07-592162}}

@article{mccourt_isolation_2015,
	Author = {McCourt, Peter Anthony and Oteiza, Ana and Cao, Ben and Nilsson, Susie},
	Doi = {10.1007/978-1-4939-1785-3_6},
	Journal = {Methods in Molecular Biology},
	Pages = {59--71},
	Title = {Isolation of murine bone marrow scavenging sinusoidal endothelial cells},
	Url = {http://www.humanapress.com/index.php?option=com_searchresult&},
	Volume = {1235},
	Year = {2015},
	Bdsk-Url-1 = {http://www.humanapress.com/index.php?option=com_searchresult&},
	Bdsk-Url-2 = {https://doi.org/10.1007/978-1-4939-1785-3_6}}

@inproceedings{moldes-anaya_targeting_2015,
	Author = {Moldes-Anaya, Angel and Kuttner, Samuel and Vincenz, Daniel and Goldschmidt, J{ü}rgen and Brun, Vegard and Kjelstrup, Kirsten Brun},
	Booktitle = {1st. {Nordic} {Neuroscience} {Meeting}},
	Title = {Targeting mnemonic pathways of stress by cerebral perfusion using 99mTc-{HMPAO} {SPECT}/{CT}},
	Year = {2015}}

@article{nome_changes_2015,
	Author = {Nome, Ragnhild and Hernes, Eivor and Bogsrud, Trond and Bj{ø}ro, Trine and Foss{å}, Sophie Dorothea},
	Doi = {10.3109/21681805.2014.982169},
	Journal = {Scandinavian journal of urology},
	Number = {3},
	Pages = {211--217},
	Title = {Changes in prostate-specific antigen, markers of bone metabolism and bone scans after treatment with radium-223},
	Url = {http://informahealthcare.com/journal/sju},
	Volume = {49},
	Year = {2015},
	Bdsk-Url-1 = {http://informahealthcare.com/journal/sju},
	Bdsk-Url-2 = {https://doi.org/10.3109/21681805.2014.982169}}

@article{norum_health_2015-1,
	Author = {Norum, Jan and Traasdahl, Erik R. and Totth, Arpad and Nieder, Carsten and Olsen, Jan Abel},
	Doi = {10.5539/gjhs.v8n4p1},
	Journal = {Global Journal of Health Science},
	Number = {4},
	Pages = {1--9},
	Title = {Health {Economics} and {Radium}-223 ({Xofigo}{\textregistered}) in the {Treatment} of {Metastatic} {Castration}-{Resistant} {Prostate} {Cancer} ({mCRPC}): {A} {Case} {History} and a {Systematic} {Review} of the {Literature}},
	Url = {http://hdl.handle.net/10037/8612},
	Volume = {8},
	Year = {2015},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/8612},
	Bdsk-Url-2 = {https://doi.org/10.5539/gjhs.v8n4p1}}

@article{schulz_respiratory_2015,
	Author = {Schulz, Anselm and Godt, Johannes Jakob C and Dormagen, Johann Baptist and Holtedahl, Jon Erik and Bogsrud, Trond and Labori, Knut J{ø}rgen and Kl{ø}w, Nils-Einar and Bach-Gansmo, Tore},
	Doi = {10.1016/j.ejrad.2015.05.011},
	Journal = {European Journal of Radiology},
	Number = {8},
	Pages = {1424--1431},
	Title = {Respiratory gated {PET}/{CT} of the liver: {A} novel method and its impact on the detection of colorectal liver metastases},
	Url = {http://www.elsevier.com/locate/ejrad},
	Volume = {84},
	Year = {2015},
	Bdsk-Url-1 = {http://www.elsevier.com/locate/ejrad},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.ejrad.2015.05.011}}

@article{storan_brief_2015,
	Author = {Storan, Melonie J. and Heazlewood, Shen Y. and Heazlewood, Chad K. and Haylock, David N. and Alexander, Warren S. and Neaves, Rebecca J. and Oteiza, Ana and Nilsson, Susan K.},
	Doi = {10.1002/stem.2038},
	Journal = {Stem Cells},
	Number = {7},
	Pages = {2351--2357},
	Title = {Brief report: {Factors} released by megakaryocytes thrombin cleave osteopontin to negatively regulate hematopoietic stem cells},
	Url = {http://stemcells.alphamedpress.org/},
	Volume = {33},
	Year = {2015},
	Bdsk-Url-1 = {http://stemcells.alphamedpress.org/},
	Bdsk-Url-2 = {https://doi.org/10.1002/stem.2038}}

@inproceedings{sa_ether_anti-diabetic_2015,
	Author = {S{æ}ther, Thomas and Moldes-Anaya, Angel and Tungen, J{ø}rn Eivind and Vik, Anders and Paulsen, Steinar Martin and Sylte, Ingebrigt and Hansen, Trond Vidar and Nebb, Hilde Irene},
	Booktitle = {{EMBO} {Conference} on {Nuclear} {Receptors}},
	Title = {Anti-diabetic activity from marine lipids: new anti-diabetic drugs},
	Year = {2015}}

@article{kranz_preclinical_2015,
	Author = {Kranz, Mathias and Sattler, B. and Wuest, Nathanael and Deuther-Conrad, Winnie and Fischer, S. and W{ü}nsch, B. and Steinbach, J{ö}rg and Sabri, Osama and Brust, Peter},
	Doi = {10.3390/molecules21091164},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 3},
	Pages = {1025--1025},
	Title = {Preclinical dose assessment of [18F] fluspidine with {PET}/{MRI}: {Enantiomeric} differences in tracer kinetics cause a significant deviation in dosimetry.},
	Volume = {56},
	Year = {2015},
	Bdsk-Url-1 = {https://doi.org/10.3390/molecules21091164}}

@article{kranz_preclinical_2015-1,
	Author = {Kranz, Mathias and Sattler, B and Patt, M and Deuther-Conrad, W and Fischer, S and Smits, R and Hoepping, A and Sabri, O and Brust, P},
	Journal = {European Journal of Nuclear Medicine and Molecular Imaging},
	Pages = {S347--S348},
	Title = {Preclinical small animal {PET}/{MRI} for radiopharmaceutical dosimetry},
	Volume = {42},
	Year = {2015}}

@article{krause_influence_2015,
	Author = {Krause, K. and Kranz, Mathias and Weiner, J. and Kl{ö}ting, N. and Rijntjes, E. and K{ö}hrle, J. and Zeisig, V. and Steinhoff, K. and Deuther-Conrad, W. and Fasshauer, M.},
	Doi = {10.1055/s-0035-1549076},
	Journal = {Experimental and Clinical Endocrinology \& Diabetes},
	Number = {03},
	Pages = {LB\_10},
	Title = {Influence of thyroid hormones on brown adipose tissue activity and browning of white adipose tissues in mice},
	Volume = {123},
	Year = {2015},
	Bdsk-Url-1 = {https://doi.org/10.1055/s-0035-1549076}}

@article{sattler_first--man_2015,
	Author = {Sattler, B and Kranz, Mathias and Patt, Marianne and Tiepolt, Solveig and Deuther-Conrad, Winnie and Smits, R and Hoepping, Alexander and Steinbach, J{ö}rg and Brust, Peter and Sabri, Osama},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 3},
	Pages = {1020--1020},
	Title = {First-in-man incorporation dosimetry of (+)-[18F] flubatine},
	Volume = {56},
	Year = {2015}}

@article{schroder_synthesis_2015,
	Author = {Schr{ö}der, Susann and Wenzel, Barbara and Deuther-Conrad, Winnie and Teodoro, Rodrigo and Egerland, Ute and Kranz, Mathias and Scheunemann, Matthias and H{ö}fgen, Norbert and Steinbach, J{ö}rg and Brust, Peter},
	Doi = {10.3390/molecules20069591},
	Journal = {Molecules},
	Number = {6},
	Pages = {9591--9615},
	Title = {Synthesis, 18F-radiolabelling and biological characterization of novel fluoroalkylated triazine derivatives for in vivo imaging of phosphodiesterase 2A in brain via positron emission tomography},
	Volume = {20},
	Year = {2015},
	Bdsk-Url-1 = {https://doi.org/10.3390/molecules20069591}}

@article{schroder_novel_2015,
	Author = {Schr{ö}der, Susann and Wenzel, Barbara and Deuther-Conrad, Winnie and Teodoro, Rodrigo and Egerland, Ute and Kranz, Mathias and Fischer, Steffen and H{ö}fgen, Norbert and Steinbach, J{ö}rg and Brust, Peter},
	Journal = {J. Labelled Compd. Rad},
	Pages = {S221},
	Title = {Novel 18F-labelled triazine derivatives for {PET} imaging of phosphodiesterase 2A},
	Volume = {58},
	Year = {2015}}

@article{schroder_synthesis_2015-1,
	Author = {Schr{ö}der, Susann and Wenzel, Barbara and Deuther-Conrad, Winnie and Teodoro, Rodrigo and Egerland, Ute and Kranz, Mathias and Scheunemann, Matthias and H{ö}fgen, Norbert and Steinbach, J{ö}rg and Brust, Peter},
	Journal = {Molecules},
	Number = {6},
	Pages = {9591--9615},
	Title = {Synthesis, 18F-radiolabelling and biological characterization of novel fluoroalkylated triazine derivatives for in vivo imaging of phosphodiesterase 2A in brain via positron emission tomography},
	Volume = {20},
	Year = {2015}}

@article{teodoro_promising_2015,
	Author = {Teodoro, Rodrigo and Scheunemann, Matthias and Deuther-Conrad, Winnie and Wenzel, Barbara and Fasoli, Francesca and Gotti, Cecilia and Kranz, Mathias and Donat, Cornelius and Patt, Marianne and Hillmer, Ansel},
	Journal = {Molecules},
	Number = {10},
	Pages = {18387--18421},
	Title = {A {Promising} {PET} {Tracer} for {Imaging} of α7 {Nicotinic} {Acetylcholine} {Receptors} in the {Brain}: {Design}, {Synthesis}, and in {Vivo} {Evaluation} of a {Dibenzothiophene}-{Based} {Radioligand}},
	Volume = {20},
	Year = {2015}}

@article{wagner_evaluation_2015,
	Author = {Wagner, Sally and Kranz, Mathias and Hankir, Mohammed and Deuther-Conrad, Winnie and Scheunemann, Matthias and Teodoro, Rodrigo and Wenzel, Barbara and Fischer, Steffen and Egerland, Ute and Fenske, Wiebke K},
	Journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	Pages = {S52--S52},
	Title = {Evaluation of the new radioligand [{F}-18] {AQ}-28A by small animal {PET}/{MR} demonstrates increase of {PDE}10A expression in striatum and brown adipose tissue ({BAT}) of obese mice},
	Volume = {58},
	Year = {2015}}

@article{wenzel_development_2015,
	Author = {Wenzel, Barbara and Mollitor, Jan and Deuther-Conrad, Winnie and Kranz, Mathias and Dukic-Stefanovic, Sladjana and Guenther, Robert and Teodoro, Rodrigo and Ludwig, Friedrich-Alexander and Fischer, Steffen and Smits, Rene},
	Journal = {Journal of Labelled Compounds \& Radiopharmaceuticals},
	Pages = {S173--S173},
	Title = {On the development of a novel non-peptidic {F}-18-labeled radiotracer for in vivo imaging of oxytocin receptors with {PET}},
	Volume = {58},
	Year = {2015}}

@article{norum_health_2015,
	Author = {Norum, Jan and Traasdahl, Erik R. and Totth, Arpad and Nieder, Carsten and Olsen, Jan Abel},
	Doi = {10.1016/j.jval.2015.09.1191},
	Journal = {Value in Health},
	Pages = {1},
	Title = {Health economics and {Radium}-223 ({Xofigo}({R})) in the treatment of metastatic castration resistant prostate cancer {mCRPC}). {A} case history and a systematic review of the literature on cost effectiveness analysis ({CEA})},
	Url = {http://hdl.handle.net/10037/9116},
	Volume = {7},
	Year = {2015},
	Bdsk-Url-1 = {http://hdl.handle.net/10037/9116},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.jval.2015.09.1191}}
%%---------Traasdahl, Erik R end---------------------------------------
%%-------Hjelstuen, Ole Kristian start----------

@article{orbo_determinants_2014,
	Author = {{Ø}rbo, Marte Christine and Aslaksen, Per M. and Larsby, Kristina and Norli, Lena and Sch{\"a}fer, Christoph and Tande, P{å}l Morten and Vangberg, Torgil Riise and Anke, Audny},
	Doi = {10.1016/j.resuscitation.2014.08.010},
	Journal = {Resuscitation},
	Number = {11},
	Pages = {1462--1468},
	Title = {Determinants of cognitive outcome in survivors of out-of-hospital cardiac arrest},
	Url = {http://www.medicaljournals.se/jrm/content/?doi=10.2340/16501977-1998},
	Volume = {85},
	Year = {2014},
	Bdsk-Url-1 = {http://www.medicaljournals.se/jrm/content/?doi=10.2340/16501977-1998},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.resuscitation.2014.08.010}}

@article{marthinussen_removal_2014,
	Author = {Marthinussen, Svein-Arne and Chang, Yu Fen and Balakin, Boris V. and Hoffmann, Alex C.},
	Doi = {10.1016/j.ces.2014.01.008},
	Journal = {Chemical Engineering Science},
	Keywords = {Hydrocyclone, Model, Pressure drop, Separation efficiency, Separation performance, Viscous liquid},
	Pages = {169--175},
	Title = {Removal of particles from highly viscous liquids with hydrocyclones},
	Url = {http://www.sciencedirect.com/science/article/pii/S0009250914000104},
	Volume = {108},
	Year = {2014},
	Bdsk-Url-1 = {http://www.sciencedirect.com/science/article/pii/S0009250914000104},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.ces.2014.01.008}}

@article{andersen_basic_2014,
	Author = {Andersen, Jan Terje and Hjelstuen, Ole Kristian and Sandlie, Inger},
	Journal = {From Basic Research to Innovation},
	Pages = {39--50},
	Title = {From {Basic} {Research} to {Innovation}},
	Year = {2014}}

@article{ahluwalia_squeezing_2014,
	Author = {Ahluwalia, Balpreet Singh and McCourt, Peter Anthony and Oteiza, Ana and Wilkinson, James S. and Huser, Thomas Rolf and Helles{ø}, Olav Gaute},
	Doi = {10.1039/C4AN01181C},
	Journal = {The Analyst},
	Pages = {223--229},
	Title = {Squeezing red blood cells with the evanescent field of an optical waveguide to monitor cell deformability during blood storage},
	Url = {http://www.rsc.org/is/journals/current/analyst/anlpub.htm},
	Volume = {140},
	Year = {2014},
	Bdsk-Url-1 = {http://www.rsc.org/is/journals/current/analyst/anlpub.htm},
	Bdsk-Url-2 = {https://doi.org/10.1039/C4AN01181C}}

@article{hagtvedt_diffusion-weighted_2014,
	Author = {Hagtvedt, Trond and Seierstad, Therese and Lund, Kjersti Vassmo and L{ø}ndalen, Ayca Muftuler and Bogsrud, Trond and Smith, Hans-J{ø}rgen and Geier, Oliver and Holte, Harald and Aal{ø}kken, Trond Mogens},
	Doi = {10.1177/0284185114526087},
	Journal = {Acta Radiologica},
	Number = {2},
	Pages = {152--158},
	Title = {Diffusion-weighted {MRI} compared to {FDG} {PET}/{CT} for assessment of early treatment response in lymphoma},
	Url = {http://informahealthcare.com/ard},
	Volume = {56},
	Year = {2014},
	Bdsk-Url-1 = {http://informahealthcare.com/ard},
	Bdsk-Url-2 = {https://doi.org/10.1177/0284185114526087}}

@article{heazlewood_analyzing_2014,
	Author = {Heazlewood, Shen Y. and Oteiza, Ana and Cao, Huimin and Nilsson, Susan K.},
	Doi = {10.1111/nyas.12329},
	Journal = {Annals of the New York Academy of Sciences},
	Number = {1},
	Pages = {119--128},
	Title = {Analyzing hematopoietic stem cell homing, lodgment, and engraftment to better understand the bone marrow niche},
	Url = {http://www.annalsnyas.org/},
	Volume = {1310},
	Year = {2014},
	Bdsk-Url-1 = {http://www.annalsnyas.org/},
	Bdsk-Url-2 = {https://doi.org/10.1111/nyas.12329}}

@article{karantanis_onkologische_2014,
	Author = {Karantanis, D. and Kalkanis, D. and Allen-Auerbach, M. S. and Herrmann, K. and Pomykala, K. L. and Bogsrud, Trond and Lowe, V. J. and Czernin, J.},
	Doi = {10.3413/Nukmed-0613-13-07},
	Journal = {Nuklearmedizin},
	Number = {2},
	Pages = {19--25},
	Title = {Onkologische {PET}/{CT}-{Interpretation} und {Erstellung} der befundberichte: {Umfrage} im klinischen bereich},
	Url = {http://nuk.schattauer.de/en/about/description.html},
	Volume = {53},
	Year = {2014},
	Bdsk-Url-1 = {http://nuk.schattauer.de/en/about/description.html},
	Bdsk-Url-2 = {https://doi.org/10.3413/Nukmed-0613-13-07}}

@article{karantanis_perceived_2014,
	Author = {Karantanis, Dimitros and Kalkanis, Dimitrios and Czernin, Johannes and Herrmann, Ken and Pomykala, Kelsey L. and Bogsrud, Trond and Subramaniam, Rathan M. and Lowe, Val J. and Allen-Auerbach, Martin S.},
	Doi = {10.2967/jnumed.114.145607},
	Journal = {Journal of Nuclear Medicine},
	Number = {12},
	Pages = {1925--1929},
	Title = {Perceived misinterpretation rates in oncologic 18F-{FDG} {PET}/{CT} studies: {A} survey of referring physicians},
	Url = {http://jnm.snmjournals.org/},
	Volume = {55},
	Year = {2014},
	Bdsk-Url-1 = {http://jnm.snmjournals.org/},
	Bdsk-Url-2 = {https://doi.org/10.2967/jnumed.114.145607}}

@article{kolstad_nordic_2014,
	Author = {Kolstad, Arne and Laurell, Anna and Jerkeman, Mats and Gronbaek, Kirsten and Elonen, Erkki and R{ä}ty, Riikka and Pedersen, Lone Bredo and Loft, Annika and Bogsrud, Trond and Kimby, Eva and Hansen, Per Boye and Fagerli, Unn-Merete and Nilsson-Ehle, Herman and Lehmann, Anne Kristine and Sundstr{ö}m, Christer and Lauritzsen, Grete Fossum and Karjalainen-Lindsberg, Marja-Liisa and Ralfkiaer, Elisabeth and Ehinger, Mats and Delabie, Jan and Bentzen, Hans and Schildt, Jukka and Kostova-Aherdan, Kamelia and Frederiksen, Henrik and Brown, Peter de Nully and Geisler, Christian H.},
	Doi = {10.1182/blood-2013-12-541953},
	Journal = {Blood},
	Number = {19},
	Pages = {2953--2959},
	Title = {Nordic {MCL}3 study: 90Y-ibritumomab-tiuxetan added to {BEAM}/{C} in non-{CR} patients before transplant in mantle cell lymphoma},
	Url = {http://www.bloodjournal.org/misc/about.shtml},
	Volume = {123},
	Year = {2014},
	Bdsk-Url-1 = {http://www.bloodjournal.org/misc/about.shtml},
	Bdsk-Url-2 = {https://doi.org/10.1182/blood-2013-12-541953}}

@inproceedings{mccourt_bone_2014,
	Author = {McCourt, Peter Anthony and Oteiza, Ana and Storan, Melonie and Williams, Brenda and Heazlewood, Chad and S{ø}rensen, Karen Kristine and Li, S and Nefzger, Christian and Kubota, Y and Polo, Jose and Nilsson, Susie},
	Booktitle = {Australasian {Stem} {Cell} {Science} and {Therapy} meeting},
	Title = {Bone marrow endothelium: {A} hierarchically organized system},
	Year = {2014}}

@article{schuster_anti-1-amino-3-18f-fluorocyclobutane-1-carboxylic_2014,
	Author = {Schuster, David M. and Nanni, Cristina and Fanti, Stefano and Oka, Shuntaro and Okudaira, Hiroyuki and Inoue, Yusuke and S{ö}rensen, Jens and Owenius, Rikard and Choyke, Peter and Turkbey, Baris and Bogsrud, Trond and Bach-Gansmo, Tore and Halkar, Raghuveer K. and Nye, Jonathon A. and Odewole, Oluwaseun A. and Savir-Baruch, Bital and Goodman, Mark M.},
	Doi = {10.2967/jnumed.114.143628},
	Journal = {Journal of Nuclear Medicine},
	Number = {12},
	Pages = {1986--1992},
	Title = {Anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid: {Physiologic} uptake patterns, incidental findings, and variants that may simulate disease},
	Url = {http://jnm.snmjournals.org/},
	Volume = {55},
	Year = {2014},
	Bdsk-Url-1 = {http://jnm.snmjournals.org/},
	Bdsk-Url-2 = {https://doi.org/10.2967/jnumed.114.143628}}

@inproceedings{sa_ether_two_2014,
	Author = {S{æ}ther, Thomas and Moldes-Anaya, Angel and Norrheim-Larsen, Laila and Larsen, Terje and Paulsen, Steinar M and Nebb, Hilde Irene},
	Booktitle = {Throne {Holst} {Symposium}},
	Title = {Two near identical oxylipins from the diatom {Chaetoceros} karianus show isoform-specific agonist activity towards human peroxisome proliferator-activated receptors ({PPARs})},
	Year = {2014}}

@article{deuther-conrad_feasibility_2014,
	Author = {Deuther-Conrad, W. and Teodoro, R. and Scheunemann, M. and Roetering, S. and Patt, M. and Kranz, Mathias and Donat, C. K. and Xiong, G. and Fischer, S. and Bucerius, J.},
	Journal = {European Journal of Nuclear Medicine and Molecular Imaging},
	Pages = {S209--S210},
	Title = {Feasibility and {Importance} of the alpha 7 {Nicotinic} {Acetylcholine} {Receptor} (alpha 7nAChR) as {Target} for {PET} {Imaging}},
	Volume = {41},
	Year = {2014}}

@article{gnad_adenosine_2014,
	Author = {Gnad, Thorsten and Scheibler, Saskia and von K{ü}gelgen, Ivar and Scheele, Camilla and Kili{ć}, Ana and Gl{ö}de, Anja and Hoffmann, Linda S and Reverte-Salisa, Laia and Horn, Philipp and Mutlu, Samet and Ali El-Tayeb and Mathias Kranz and Winnie Deuther-Conrad and Peter Brust and Martin E. Lidell and Matthias J. Betz and Sven Enerb{ä}ck and J{ü}rgen Schrader and Gennady G. Yegutkin and Christa E. M{ü}ller and Alexander Pfeifer},
	Doi = {10.1038/nature13816},
	Journal = {Nature},
	Number = {7531},
	Pages = {395},
	Title = {Adenosine activates brown adipose tissue and recruits beige adipocytes via {A} 2A receptors},
	Volume = {516},
	Year = {2014},
	Bdsk-Url-1 = {https://doi.org/10.1038/nature13816}}

@article{kranz_preclinical_2014,
	Author = {Kranz, Mathias and Sattler, B and Deuther-Conrad, Winnie and Teodoro, Rodrigo and Donat, Cornelius and Wenzel, Barbara and Scheunemann, Matthias and Patt, Marianne and Sabri, Osama and Brust, Peter},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 1},
	Pages = {1143--1143},
	Title = {Preclinical dose assessment and biodistribution of [18F] {DBT}10, a new α7 nicotinic acetylcholine receptor (α7-{nAChR}) imaging ligand},
	Volume = {55},
	Year = {2014}}

@article{kranz_preclinical_2014-1,
	Author = {Kranz, Mathias and Sattler, B and Patt, Marianne and Donat, Cornelius and Deuther-Conrad, Winnie and Hiller, Achim and Smits, R and Hoepping, Alexander and Sabri, Osama and Brust, Peter},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 1},
	Pages = {1140--1140},
	Title = {Preclinical {PET}/{MRI}-{First} time use and validation of a potential tool for image based dosimetry},
	Volume = {55},
	Year = {2014}}

@article{krause_influence_2014,
	Author = {Krause, K. and Kranz, Mathias and Zeisig, V. and Kl{ö}ting, N. and Steinhoff, K. and Deuther-Conrad, W. and Fasshauer, M. and Stumvoll, M. and Sabri, O. and Hesse, S.},
	Journal = {Diabetologie und Stoffwechsel},
	Number = {S 01},
	Pages = {FV22},
	Title = {The influence of thyroid dysfunction on the activity of brown adipose tissue in mice detected by [18F] {FDG} {PET}/{MR}},
	Volume = {9},
	Year = {2014}}

@article{sattler_internal_2014,
	Author = {Sattler, Bernhard and Kranz, Mathias and Starke, Alexander and Wilke, Stephan and Donat, Cornelius K and Deuther-Conrad, Winnie and Patt, Marianne and Schildan, Andreas and Patt, J{ö}rg and Smits, Ren{é} and Alexander Hoepping and Peter Schoenknecht and J{ö}rg Steinbach and Peter Brust and Osama Sabri},
	Doi = {10.2967/jnumed.114.137059},
	Journal = {Journal of Nuclear Medicine},
	Number = {11},
	Pages = {1885--1892},
	Title = {Internal {Dose} {Assessment} of (--)-18F-{Flubatine}, {Comparing} {Animal} {Model} {Datasets} of {Mice} and {Piglets} with {First}-in-{Human} {Results}},
	Volume = {55},
	Year = {2014},
	Bdsk-Url-1 = {https://doi.org/10.2967/jnumed.114.137059}}

@article{schroder_development_2014,
	Author = {Schr{ö}der, S. and Wenzel, B. and Kranz, Mathias and Egerland, U. and Teodoro, R. and Deuther-Conrad, W. and Fischer, S. and H{ö}fgen, N. and Steinbach, J. and Brust, P.},
	Journal = {Eur. J. Nucl. Med. Mol. Imaging},
	Pages = {S197},
	Title = {Development, synthesis and {F}-18 labelling of a fluoroalkylated triazine derivative for {PET} imaging of phosphodiesterase 2A},
	Volume = {41},
	Year = {2014}}

@article{steinhoff_impact_2014,
	Author = {Steinhoff, K. and Kranz, Mathias and Zeisig, V. and Deuther-Conrad, W. and Fasshauer, M. and Stumvoll, M. and Toenjes, A. and Brust, P. and Sabri, O. and Hesse, S.},
	Journal = {European Journal of Nuclear Medicine and Molecular Imaging},
	Pages = {S264--S264},
	Title = {Impact of thyroid hormones on the regulation of brown adipose tissue ({BAT}) activity in mice detected by combined [18F] {FDG}-{PET}/{MR} imaging},
	Volume = {41},
	Year = {2014}}

@article{NovusForlag2014,
	Author = {Andersen, Jan Terje and Hjelstuen, Ole Kristian and Sandlie, Inger},
	Title = {From Basic Research to Innovation},
	Journal = {Novus Forlag},
	Year = {2014},
	ISBN = {978-82-7099-791-6},
	Pages = {39--50}}

@article{rogne_mild_2013,
	Author = {Rogne, Sigbj{ø}rn Olav and Vangberg, Torgil and Eldevik, Odd Petter and Wikran, Gry Charlotte and Mathiesen, Ellisiv B. and Schirmer, Henrik},
	Doi = {10.1159/000350408},
	Journal = {Dementia and Geriatric Cognitive Disorders},
	Number = {1-2},
	Pages = {87--98},
	Title = {Mild cognitive impairment, risk factors and magnetic resonance volumetry: role of probable {Alzheimer}'s disease in the family},
	Url = {http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&},
	Volume = {36},
	Year = {2013},
	Bdsk-Url-1 = {http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&},
	Bdsk-Url-2 = {https://doi.org/10.1159/000350408}}

@article{rodriguez-aranda_brain_2013,
	Author = {Rodriguez-Aranda, Claudia and Espenes, Ragna and Holthe, Marit Moe and Waterloo, Knut and Vangberg, Torgil Riise},
	Journal = {Society for Neuroscience; 43th Annual Meeting},
	Title = {Brain activation patterns during semantic verbal fluency in active and educated healthy seniors: {A} covert {fMRI} study},
	Year = {2013}}
%%--------------------------Vangberg end---------------------------
%% --------------Y.-F. Chang start--------------------------------------------------------

@article{chang_pept:_2013,
	Author = {Chang, Yu Fen and Adamsen, Tom C. H. and Pisarev, Gleb I. and Hoffmann, Alex C.},
	Doi = {10.1051/epjconf/20135005001},
	Journal = {European Physical Journal: Web of Conferences},
	Title = {{PEPT}: {An} invaluable tool for 3-{D} particle tracking and {CFD} simulation verification in hydrocyclone studies},
	Url = {https://doi.org/10.1051/epjconf/20135005001},
	Volume = {50},
	Year = {2013},
	Bdsk-Url-1 = {https://doi.org/10.1051/epjconf/20135005001}}

@inproceedings{marthinussen_hydrocyclones_2013,
	Author = {Marthinussen, S. and Chang, Y. F. and Balakin, B. V. and Addicks, L. and Hoffmann, A. C.},
	Booktitle = {{PARTEC} - {International} {Congress} on {Particle} {Technology}},
	Title = {Hydrocyclones working on highly viscous liquids},
	Doi = {10.13140/RG.2.2.34835.58406},
	Year = {2013}}
%% --------------Y.-F. Chang end--------------------------------------------------------
%% --------------Yngve Guttormsen start from 2019--------------------------------------------------------

@article{meknas_medium-term_2013,
	Author = {Meknas, Khaled and Al Hassoni, Thabit N and Odden-Miland, {Å}shild and Castillejo, Miguel and Kartus, J{ü}ri},
	Doi = {10.1177/2325967113505433},
	Journal = {Orthopaedic journal of sports medicine},
	Number = {4},
	Pages = {2325967113505433},
	Title = {Medium-term results after treatment of recalcitrant lateral epicondylitis: a prospective, randomized study comparing open release and radiofrequency microtenotomy},
	Volume = {1},
	Year = {2013},
	Bdsk-Url-1 = {https://doi.org/10.1177/2325967113505433}}

@article{berntsen_mechanisms_2013,
	Author = {Berntsen, H. F. and Wigestrand, Mattis Br{æ}nne and Bogen, Inger Lise and Fonnum, Frode and Walaas, S. Ivar and Moldes-Anaya, Angel},
	Doi = {10.1016/j.neuro.2013.01.004},
	Journal = {Neurotoxicology},
	Pages = {129--136},
	Title = {Mechanisms of penitrem-induced cerebellar granule neuron death in vitro: {Possible} involvement of {GABA}({A}) receptors and oxidative processes},
	Url = {http://www.elsevier.com/wps/product/cws_home/621355},
	Volume = {35},
	Year = {2013},
	Bdsk-Url-1 = {http://www.elsevier.com/wps/product/cws_home/621355},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.neuro.2013.01.004}}

@article{cao_understanding_2013,
	Author = {Cao, Huimin and Oteiza, Ana and Nilsson, Susan K.},
	Doi = {10.1016/j.exphem.2013.06.005},
	Journal = {Experimental Hematology},
	Number = {9},
	Pages = {761--768},
	Title = {Understanding the role of the microenvironment during definitive hemopoietic development},
	Url = {http://www.elsevier.com/wps/find/journaldescription.cws_home/601451/description#description},
	Volume = {41},
	Year = {2013},
	Bdsk-Url-1 = {http://www.elsevier.com/wps/find/journaldescription.cws_home/601451/description#description},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.exphem.2013.06.005}}

@article{eriksen_penitrem_2013,
	Author = {Eriksen, Gunnar Sundst{ø}l and Moldes-Anaya, Angel and F{æ}ste, Christiane Kruse},
	Doi = {10.3920/WMJ2013.1574},
	Journal = {World Mycotoxin Journal},
	Number = {3},
	Pages = {263--272},
	Title = {Penitrem {A} and analogues: toxicokinetics, toxicodynamics including mechanism of action and clinical significance},
	Url = {http://www.worldmycotoxinjournal.org/},
	Volume = {6},
	Year = {2013},
	Bdsk-Url-1 = {http://www.worldmycotoxinjournal.org/},
	Bdsk-Url-2 = {https://doi.org/10.3920/WMJ2013.1574}}

@article{johnsrud_characterization_2013,
	Author = {Johnsrud, Kjersti and Skretting, Arne and Naum, Alexandru Gratian and Bogsrud, Trond and Bach-Gansmo, Tore},
	Doi = {10.1111/cpf.12057},
	Journal = {Clinical Physiology and Functional Imaging},
	Number = {6},
	Pages = {478--482},
	Title = {Characterization of an asymmetric add-on collimator used with a hand-held gamma probe for radioguided surgery and sentinel node detection: a demonstration of an alternative collimation method},
	Url = {http://www.blackwellpublishing.com/journal.asp?ref=1475-0961&},
	Volume = {33},
	Year = {2013},
	Bdsk-Url-1 = {http://www.blackwellpublishing.com/journal.asp?ref=1475-0961&},
	Bdsk-Url-2 = {https://doi.org/10.1111/cpf.12057}}

@article{kuttner_proposed_2013,
	Author = {Kuttner, Samuel and Bujila, Robert and Kortesniemi, Mika and Andersson, Henrik and Kull, Love and {Ø}ster{å}s, Bj{ø}rn Helge and Thygesen, Jesper and Tarp, Ivanka Sojat},
	Doi = {10.1258/ar.2012.120254},
	Journal = {Acta Radiologica},
	Number = {2},
	Pages = {188--198},
	Title = {A proposed protocol for acceptance and constancy control of computed tomography systems: {A} {Nordic} {Association} for {Clinical} {Physics} ({NACP}) work group report},
	Url = {http://informahealthcare.com/ard},
	Volume = {54},
	Year = {2013},
	Bdsk-Url-1 = {http://informahealthcare.com/ard},
	Bdsk-Url-2 = {https://doi.org/10.1258/ar.2012.120254}}

@article{mccourt_bm_2013,
	Abstract = {Hemopoietic stem cells reside in marrow niches and are responsible for producing all circulating blood cells. Interfacing blood and the niche are sinusoidal endothelial cell lined vessels, with immense endocytic capacity. Bone marrow sinusoids have previously been identified as critical in stem cell regulation, comprising a key component of the niche. However, little is known about the characteristics or functional capacity of bone marrow endothelial cells. We have recently identified, prospectively isolated and characterized bone marrow scavenging endothelial cells (BMSEC), demonstrating a hierarchical organization and a subpopulation highly enriched for endothelial stem cells with long-term serial transplant potential, revascularization of recipient marrow as well as giving rise to long-term multi-lineage reconstituting HSC (LSK SLAM) at a frequency of 1 in 250. Furthermore, HSC themselves, were shown to be bi-potent and demonstrated hemangioblast potential at the single cell level post-transplant: reconstitution of hemopoiesis and recapitulating the complete endothelial cell hierarchy. Endothelial stem cells derived from HSC were also serially transplantable re-recapitulating the complete endothelial cell hierarchy. These findings represent a major advance in the understanding of HSC and marrow endothelial cells, and importantly the recognition of the ability of each population to give rise to the other in vivo. Identification of human counterparts of these endothelial cells and their use in transplantation may lead to improved clinical outcomes.},
	Author = {McCourt, Peter Anthony and Oteiza, Ana and Storan, Melonie and Williams, Brenda and Heazlewood, Chad and S{ø}rensen, Karen Kristine and Nilsson, Susie},
	Journal = {Keystone Symposia: Hematopoiesis (A4)},
	Title = {{BM} endothelial stem cells are hierarchically organized and transplantable, giving rise to functional blood vessels as well as {HSC}; themselves representing the adult hemangioblast, capable of hemopoietic and endothelial reconstitution},
	Year = {2013}}

Hemopoietic stem cells reside in marrow niches and are responsible for producing all circulating blood cells. Interfacing blood and the niche are sinusoidal endothelial cell lined vessels, with immense endocytic capacity. Bone marrow sinusoids have previously been identified as critical in stem cell regulation, comprising a key component of the niche. However, little is known about the characteristics or functional capacity of bone marrow endothelial cells. We have recently identified, prospectively isolated and characterized bone marrow scavenging endothelial cells (BMSEC), demonstrating a hierarchical organization and a subpopulation highly enriched for endothelial stem cells with long-term serial transplant potential, revascularization of recipient marrow as well as giving rise to long-term multi-lineage reconstituting HSC (LSK SLAM) at a frequency of 1 in 250. Furthermore, HSC themselves, were shown to be bi-potent and demonstrated hemangioblast potential at the single cell level post-transplant: reconstitution of hemopoiesis and recapitulating the complete endothelial cell hierarchy. Endothelial stem cells derived from HSC were also serially transplantable re-recapitulating the complete endothelial cell hierarchy. These findings represent a major advance in the understanding of HSC and marrow endothelial cells, and importantly the recognition of the ability of each population to give rise to the other in vivo. Identification of human counterparts of these endothelial cells and their use in transplantation may lead to improved clinical outcomes.

@inproceedings{moldes-anaya_identifying_2013,
	Author = {Moldes-Anaya, Angel and S{æ}ther, Thomas and Larsen, Laila Norrheim and Larsen, Terje and Nebb, Hilde Irene and Paulsen, Steinar},
	Booktitle = {6th {BIOPROSP}},
	Title = {Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae},
	Year = {2013}}

@inproceedings{moldes-anaya_identifying_2013-1,
	Author = {Moldes-Anaya, Angel and S{æ}ther, Thomas and Norrheim-Larsen, Laila and Nebb, Hilde Irene and Larsen, Terje and Paulsen, Steinar},
	Booktitle = {14th. {International} {Symposium} on {Marine} {Natural} {Products} and 8th. {European} {Conference} on {Marine} {Natural} {Products} ({MANAPRO})},
	Title = {Identifying natural products with agonist or modulatory activity against human nuclear receptors in extracts from cultured marine microalgae},
	Year = {2013}}

@article{skretting_gel_2013,
	Author = {Skretting, Arne and Evensen, Jan Folkvard and L{ø}ndalen, Ayca Muftuler and Bogsrud, Trond and Glomset, Otto K{Å}re and Eilertsen, Karsten},
	Doi = {10.3109/0284186X.2012.718095},
	Journal = {Acta Oncologica},
	Number = {3},
	Pages = {636--644},
	Title = {A gel tumour phantom for assessment of the accuracy of manual and automatic delineation of gross tumour volume from {FDG}-{PET}/{CT}},
	Url = {http://informahealthcare.com/journal/onc},
	Volume = {52},
	Year = {2013},
	Bdsk-Url-1 = {http://informahealthcare.com/journal/onc},
	Bdsk-Url-2 = {https://doi.org/10.3109/0284186X.2012.718095}}

@article{skretting_implementation_2013,
	Author = {Skretting, Arne and Revheim, Mona Elisabeth and Knudtsen, Ingerid Skjei and Johnsrud, Kjersti and Bogsrud, Trond},
	Doi = {10.1177/0284185113478007},
	Journal = {Acta Radiologica},
	Number = {6},
	Pages = {672--675},
	Title = {An implementation of time-efficient respiratory-gated {PET} acquisition by repeated breath-holds},
	Url = {http://informahealthcare.com/ard},
	Volume = {54},
	Year = {2013},
	Bdsk-Url-1 = {http://informahealthcare.com/ard},
	Bdsk-Url-2 = {https://doi.org/10.1177/0284185113478007}}

@article{svistounov_hepatic_2013,
	Author = {Svistounov, Dmitri and Oteiza, Ana and Zykova, Svetlana and S{ø}rensen, Karen Kristine and McCourt, Peter Anthony and McLachlan, Andrew J and Mccuskey, Robert Scott and Smedsr{ø}d, B{Å}rd},
	Doi = {10.1016/j.exger.2013.03.005},
	Journal = {Experimental Gerontology},
	Number = {6},
	Pages = {549--556},
	Title = {Hepatic disposal of advanced glycation end products during maturation and aging},
	Url = {http://www.elsevier.com/wps/find/journaldescription.cws_home/525468/description#description},
	Volume = {48},
	Year = {2013},
	Bdsk-Url-1 = {http://www.elsevier.com/wps/find/journaldescription.cws_home/525468/description#description},
	Bdsk-Url-2 = {https://doi.org/10.1016/j.exger.2013.03.005}}

@inproceedings{sa_ether_identifying_2013,
	Abstract = {Nuclear receptors (NRs) are highly conserved transcription factors that regulate transcription in response to small lipophilic molecules. These receptors regulate the expression of genes involved in many critical processes such as embryonic development, metabolism and inflammation. Dysfunctional signalling of NRs is thought to be involved in diseases such as cancer, type 2 diabetes, obesity and dyslipidemia. All these facts make NRs attractive targets for pharmacological intervention and development of therapeutics. Several NR ligands with well-recognised biological effects are in clinical use, like the hypolipidemic fibrates (e.g. Tricor), acting as peroxisome proliferator-activated receptors alpha (PPARα) activators, and the anti-diabetic thiazolidinediones (e.g. Avandia), targeting PPARγ. However, the negative side effects reported for thiazolidinediones points to the need of finding new medicines for treating diseases like type 2 diabetes. A bioassay guided strategy on identification, purification and characterisation of PPAR ligands from cultured microalgae is presented here. We are making use of biologically assay systems incorporating unique protein targets to identify secondary metabolites possessing desirable pharmacological profile from extract generated from microalgae cultures. We have identified PPAR agonist activity in organic extracts from xenic cultures of marine diatoms. Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae},
	Author = {S{æ}ther, Thomas and Moldes-Anaya, Angel and Larsen, Laila Norrheim and Larsen, Terje and Paulsen, Steinar and Nebb, Hilde Irene},
	Booktitle = {Keystone {Symposia} - {Nuclear} {Receptors} and {Friends}: {Roles} in {Energy} {Homeostasis} and {Metabolic} {Dysfunction}},
	Title = {Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae},
	Year = {2013}}

Nuclear receptors (NRs) are highly conserved transcription factors that regulate transcription in response to small lipophilic molecules. These receptors regulate the expression of genes involved in many critical processes such as embryonic development, metabolism and inflammation. Dysfunctional signalling of NRs is thought to be involved in diseases such as cancer, type 2 diabetes, obesity and dyslipidemia. All these facts make NRs attractive targets for pharmacological intervention and development of therapeutics. Several NR ligands with well-recognised biological effects are in clinical use, like the hypolipidemic fibrates (e.g. Tricor), acting as peroxisome proliferator-activated receptors alpha (PPARα) activators, and the anti-diabetic thiazolidinediones (e.g. Avandia), targeting PPARγ. However, the negative side effects reported for thiazolidinediones points to the need of finding new medicines for treating diseases like type 2 diabetes. A bioassay guided strategy on identification, purification and characterisation of PPAR ligands from cultured microalgae is presented here. We are making use of biologically assay systems incorporating unique protein targets to identify secondary metabolites possessing desirable pharmacological profile from extract generated from microalgae cultures. We have identified PPAR agonist activity in organic extracts from xenic cultures of marine diatoms. Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae

@inproceedings{sa_ether_identifying_2013-1,
	Author = {S{æ}ther, Thomas and Moldes-Anaya, Angel and Norrheim-Larsen, Laila and Larsen, Terje and Paulsen, Steinar M and Nebb, Hilde Irene},
	Booktitle = {Throne {Holst} {Symposium}},
	Title = {Identifying natural products with agonist activity against human nuclear receptors in extracts of cultured marine microalgae},
	Year = {2013}}

@article{kranz_preclinical_2013,
	Author = {Kranz, Mathias and Sattler, B. and Deuther-Conrad, Winnie and Fischer, S. and Hiller, Achim and Donat, C. and W{ü}nsch, B. and Steinbach, J{ö}rg and Sabri, Osama and Brust, P.},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 2},
	Pages = {1028--1028},
	Title = {Preclinical dose assessment of ({S})-(-)-[18F] fluspidine and ({R})-(+)-[18F] fluspidine, new {PET} tracers for imaging of σ1 receptors},
	Volume = {54},
	Year = {2013}}

@inproceedings{sattler_preclinical_2013,
	Author = {Sattler, B and Patt, M and Sabri, O and Kranz, Mathias and Donat, CK and Deuther-Conrad, W and Fischer, S and Brust, P and Sattler, T and Smits, R},
	Booktitle = {{EANM}'13 - {Annual} {Congress} of the {European} {Association} of {Nuclear} {Medicine}},
	Title = {Preclinical incorporation dosimetry of (+)-[18 {F}) flubatine in piglets},
	Year = {2013}}

@article{sattler_preclinical_2013-1,
	Author = {Sattler, B and Kranz, Mathias and Patt, Marianne and Donat, C and Deuther-Conrad, Winnie and Fischer, S and Smits, R and Hoepping, Alexander and Brust, P and Sabri, Osama},
	Journal = {Journal of Nuclear Medicine},
	Number = {supplement 2},
	Pages = {1020--1020},
	Title = {Preclinical incorporation dosimetry of (+)-[18F] flubatine},
	Volume = {54},
	Year = {2013}}