Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care

Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Aabenhus, R., Jensen, J. S, Jørgensen, K. J., Hróbjartsson, A., & Bjerrum, L. Cochrane Database of Systematic Reviews, November, 2014.

Paper doi abstract bibtex

Background Acute respiratory infections (ARIs) are by far the most common reason for prescribing an antibiotic in primary care, even though the majority of ARIs are of viral or non-severe bacterial aetiology. Unnecessary antibiotic use will, in many cases, not be beneﬁcial to the patients’ recovery and expose them to potential side effects. Furthermore, as a causal link exists between antibiotic use and antibiotic resistance, reducing unnecessary antibiotic use is a key factor in controlling this important problem. Antibiotic resistance puts increasing burdens on healthcare services and renders patients at risk of future ineffective treatments, in turn increasing morbidity and mortality from infectious diseases. One strategy aiming to reduce antibiotic use in primary care is the guidance of antibiotic treatment by use of a point-of-care biomarker. A point-of-care biomarker of infection forms part of the acute phase response to acute tissue injury regardless of the aetiology (infection, trauma and inﬂammation) and may in the correct clinical context be used as a surrogate marker of infection, possibly assisting the doctor in the clinical management of ARIs.

@article{aabenhus_biomarkers_2014-1,
	title = {Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care},
	issn = {14651858},
	url = {http://doi.wiley.com/10.1002/14651858.CD010130.pub2},
	doi = {10.1002/14651858.CD010130.pub2},
	abstract = {Background Acute respiratory infections (ARIs) are by far the most common reason for prescribing an antibiotic in primary care, even though the majority of ARIs are of viral or non-severe bacterial aetiology. Unnecessary antibiotic use will, in many cases, not be beneﬁcial to the patients’ recovery and expose them to potential side effects. Furthermore, as a causal link exists between antibiotic use and antibiotic resistance, reducing unnecessary antibiotic use is a key factor in controlling this important problem. Antibiotic resistance puts increasing burdens on healthcare services and renders patients at risk of future ineffective treatments, in turn increasing morbidity and mortality from infectious diseases. One strategy aiming to reduce antibiotic use in primary care is the guidance of antibiotic treatment by use of a point-of-care biomarker. A point-of-care biomarker of infection forms part of the acute phase response to acute tissue injury regardless of the aetiology (infection, trauma and inﬂammation) and may in the correct clinical context be used as a surrogate marker of infection, possibly assisting the doctor in the clinical management of ARIs.},
	language = {en},
	urldate = {2019-05-02},
	journal = {Cochrane Database of Systematic Reviews},
	author = {Aabenhus, Rune and Jensen, Jens-Ulrik S and Jørgensen, Karsten Juhl and Hróbjartsson, Asbjørn and Bjerrum, Lars},
	editor = {{Cochrane Acute Respiratory Infections Group}},
	month = nov,
	year = {2014},
	file = {Aabenhus et al. - 2014 - Biomarkers as point-of-care tests to guide prescri.pdf:/Users/neil.hawkins/Zotero/storage/JFIEJM6M/Aabenhus et al. - 2014 - Biomarkers as point-of-care tests to guide prescri.pdf:application/pdf},
}

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