Chemical, spectroscopic characterization, DFT studies and initial pharmacological assays of a silver(I) complex with N-acetyl-L-cysteine

Chemical, spectroscopic characterization, DFT studies and initial pharmacological assays of a silver(I) complex with N-acetyl-L-cysteine. Abbehausen, C., Heinrich, T. A., Abrão, E. P., Costa-Neto, C. M., Lustri, W. R., Formiga, A. L. B., & Corbi, P. P. Polyhedron, 30:579–583, 2011.
abstract bibtex

A new silver(I) complex with N-acetyl- L -cysteine (NAC) of composition AgC 5 H 8 NO 3 S.H 2 O was synthesized and characterized by a set of chemical and spectroscopic measurements. Solid-state 13C nuclear magnetic resonance (SSNMR) and infrared (IR) analyses indicate the coordination of the ligand to Ag(I) through the sulfur atom. The Ag–NAC complex is slightly soluble in dimethyl sulfoxide. It is insoluble in water, methanol, ethanol, acetone and hexane. Antibacterial activity of the silver complex with N-acetyl- L -cysteine (Ag–NAC) was evaluated by antibiogram assays using the disc diffusion method. The compound showed an effective antibacterial activity against Staphylococcus aureus (Gram-positive), Escherichia coli and Pseudomonas aeruginosa (Gram-negative) bacterial cells. Biological analysis for eval- uation of a potential cytotoxic effect of Ag–NAC was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented a signi?cant cytotoxic activity, inducing 80% of cell death at a concentration of 200 micromol L -1.

@article{abbehausen_chemical_2011,
	title = {Chemical, spectroscopic characterization, {DFT} studies and initial pharmacological assays of a silver({I}) complex with {N}-acetyl-{L}-cysteine},
	volume = {30},
	abstract = {A new silver(I) complex with N-acetyl- L -cysteine (NAC) of composition AgC 5 H 8 NO 3 S.H 2 O was synthesized and characterized by a set of chemical and spectroscopic measurements. Solid-state 13C nuclear magnetic resonance (SSNMR) and infrared (IR) analyses indicate the coordination of the ligand to Ag(I) through the sulfur atom. The Ag–NAC complex is slightly soluble in dimethyl sulfoxide. It is insoluble in water, methanol, ethanol, acetone and hexane. Antibacterial activity of the silver complex with N-acetyl- L -cysteine (Ag–NAC) was evaluated by antibiogram assays using the disc diffusion method. The compound showed an effective antibacterial activity against Staphylococcus aureus (Gram-positive), Escherichia coli and Pseudomonas aeruginosa (Gram-negative) bacterial cells. Biological analysis for eval- uation of a potential cytotoxic effect of Ag–NAC was performed using HeLa cells derived from human cervical adenocarcinoma. The complex presented a signi?cant cytotoxic activity, inducing 80\% of cell death at a concentration of 200 micromol L -1.},
	journal = {Polyhedron},
	author = {Abbehausen, C. and Heinrich, T. A. and Abrão, E. P. and Costa-Neto, C. M. and Lustri, W. R. and Formiga, A. L. B. and Corbi, P. P.},
	year = {2011},
	pages = {579--583},
}

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