Computer Methods and Programs in Biomedicine, 111(2):435-446, Elsevier Ireland Ltd, 6, 2013. Paper Website abstract bibtex 2 downloads
Epithelial to mesenchymal transition (EMT) is a fundamental process during develop- ment and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Com- puter simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell–matrix adhesion in addition to modulating cell–cell adhesion.