Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation. Abecassis, S., Giustiniani, J., Meyer, N., Schiavon, V., Ortonne, N., Campillo, J., A., Bagot, M., & Bensussan, A. J Invest Dermatol, 127(5):1161-1166, 2007. ![Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation [link]](https://bibbase.org/img/filetypes/link.svg "link")
Website abstract bibtex CD160 is a glycosylphosphatidylinositol-anchored cell surface molecule expressed by human circulating cytotoxic lymphocytes that correspond to the majority of natural killer cell (NK) expressing CD56(dim), TCRgammadelta lymphocytes, and to a minor CD8 T-cell subset. CD160 engagement by major histocompatibility complex class I molecules triggers by itself both cytotoxic function and cytokine production in NK lymphocytes, whereas it provides co-activating signals to TCR-induced proliferation in T CD8+ lymphocytes. In this study, we analyzed by immunohistochemistry the phenotype of lymphocytes infiltrating normal skin and inflammatory skin lesions of atopic dermatitis, contact dermatitis, and psoriasis. We identified a minor original subset of CD4+ CD160+ T cells infiltrating inflammatory lesions. We found that this lymphocyte subset localization is not restricted to the skin, as we demonstrated that CD160 transcripts could be induced in IL-2 or IL-15-activated CD4+ peripheral blood lymphocytes. Finally, we report that CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Thus, we hypothesize that the unique CD4+ CD160+ lymphocyte subset plays a role in the pathogenesis of skin inflammation.
@article{
title = {Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation},
type = {article},
year = {2007},
identifiers = {[object Object]},
keywords = {Adolescent,Adult,Aged,Amino Acid Sequence,Antigens, CD/genetics/*physiology,CD4-Positive T-Lymphocytes/immunology/*pathology,Cells, Cultured,Dermatitis, Atopic/etiology/*immunology,Dermatitis, Contact/etiology/*immunology,Female,Humans,Male,Middle Aged,Molecular Sequence Data,Psoriasis/etiology/*immunology,RNA, Messenger/genetics/physiology,Receptors, Immunologic/genetics/*physiology,Skin/immunology/*pathology/physiopathology,T-Lymphocyte Subsets/immunology/*pathology},
pages = {1161-1166},
volume = {127},
websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17218942},
edition = {2007/01/16},
id = {26971d24-badd-3f4e-b6b4-3d5c1e3ece45},
created = {2017-06-19T13:43:58.493Z},
file_attached = {false},
profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},
group_id = {b2078731-0913-33b9-8902-a53629a24e83},
last_modified = {2017-06-19T13:43:58.696Z},
read = {false},
starred = {false},
authored = {false},
confirmed = {true},
hidden = {false},
source_type = {Journal Article},
language = {eng},
notes = {<m:note>Abecassis, Sofia<m:linebreak/>Giustiniani, Jerome<m:linebreak/>Meyer, Nicolas<m:linebreak/>Schiavon, Valerie<m:linebreak/>Ortonne, Nicolas<m:linebreak/>Campillo, Jose A<m:linebreak/>Bagot, Martine<m:linebreak/>Bensussan, Armand<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>United States<m:linebreak/>The Journal of investigative dermatology<m:linebreak/>5700680<m:linebreak/>J Invest Dermatol. 2007 May;127(5):1161-6. Epub 2007 Jan 11.</m:note>},
abstract = {CD160 is a glycosylphosphatidylinositol-anchored cell surface molecule expressed by human circulating cytotoxic lymphocytes that correspond to the majority of natural killer cell (NK) expressing CD56(dim), TCRgammadelta lymphocytes, and to a minor CD8 T-cell subset. CD160 engagement by major histocompatibility complex class I molecules triggers by itself both cytotoxic function and cytokine production in NK lymphocytes, whereas it provides co-activating signals to TCR-induced proliferation in T CD8+ lymphocytes. In this study, we analyzed by immunohistochemistry the phenotype of lymphocytes infiltrating normal skin and inflammatory skin lesions of atopic dermatitis, contact dermatitis, and psoriasis. We identified a minor original subset of CD4+ CD160+ T cells infiltrating inflammatory lesions. We found that this lymphocyte subset localization is not restricted to the skin, as we demonstrated that CD160 transcripts could be induced in IL-2 or IL-15-activated CD4+ peripheral blood lymphocytes. Finally, we report that CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Thus, we hypothesize that the unique CD4+ CD160+ lymphocyte subset plays a role in the pathogenesis of skin inflammation.},
bibtype = {article},
author = {Abecassis, S and Giustiniani, J and Meyer, N and Schiavon, V and Ortonne, N and Campillo, J A and Bagot, M and Bensussan, A},
journal = {J Invest Dermatol},
number = {5}
}
Downloads: 0
{"_id":"zAnoEyKmYyuvbTmtT","bibbaseid":"abecassis-giustiniani-meyer-schiavon-ortonne-campillo-bagot-bensussan-identificationofanovelcd160cd4tlymphocytesubsetintheskinapossibleroleforcd160inskininflammation-2007","downloads":0,"creationDate":"2017-06-19T14:46:34.363Z","title":"Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation","author_short":["Abecassis, S.","Giustiniani, J.","Meyer, N.","Schiavon, V.","Ortonne, N.","Campillo, J., A.","Bagot, M.","Bensussan, A."],"year":2007,"bibtype":"article","biburl":null,"bibdata":{"title":"Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation","type":"article","year":"2007","identifiers":"[object Object]","keywords":"Adolescent,Adult,Aged,Amino Acid Sequence,Antigens, CD/genetics/*physiology,CD4-Positive T-Lymphocytes/immunology/*pathology,Cells, Cultured,Dermatitis, Atopic/etiology/*immunology,Dermatitis, Contact/etiology/*immunology,Female,Humans,Male,Middle Aged,Molecular Sequence Data,Psoriasis/etiology/*immunology,RNA, Messenger/genetics/physiology,Receptors, Immunologic/genetics/*physiology,Skin/immunology/*pathology/physiopathology,T-Lymphocyte Subsets/immunology/*pathology","pages":"1161-1166","volume":"127","websites":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17218942","edition":"2007/01/16","id":"26971d24-badd-3f4e-b6b4-3d5c1e3ece45","created":"2017-06-19T13:43:58.493Z","file_attached":false,"profile_id":"de68dde1-2ff3-3a4e-a214-ef424d0c7646","group_id":"b2078731-0913-33b9-8902-a53629a24e83","last_modified":"2017-06-19T13:43:58.696Z","read":false,"starred":false,"authored":false,"confirmed":"true","hidden":false,"source_type":"Journal Article","language":"eng","notes":"<m:note>Abecassis, Sofia<m:linebreak/>Giustiniani, Jerome<m:linebreak/>Meyer, Nicolas<m:linebreak/>Schiavon, Valerie<m:linebreak/>Ortonne, Nicolas<m:linebreak/>Campillo, Jose A<m:linebreak/>Bagot, Martine<m:linebreak/>Bensussan, Armand<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>United States<m:linebreak/>The Journal of investigative dermatology<m:linebreak/>5700680<m:linebreak/>J Invest Dermatol. 2007 May;127(5):1161-6. Epub 2007 Jan 11.</m:note>","abstract":"CD160 is a glycosylphosphatidylinositol-anchored cell surface molecule expressed by human circulating cytotoxic lymphocytes that correspond to the majority of natural killer cell (NK) expressing CD56(dim), TCRgammadelta lymphocytes, and to a minor CD8 T-cell subset. CD160 engagement by major histocompatibility complex class I molecules triggers by itself both cytotoxic function and cytokine production in NK lymphocytes, whereas it provides co-activating signals to TCR-induced proliferation in T CD8+ lymphocytes. In this study, we analyzed by immunohistochemistry the phenotype of lymphocytes infiltrating normal skin and inflammatory skin lesions of atopic dermatitis, contact dermatitis, and psoriasis. We identified a minor original subset of CD4+ CD160+ T cells infiltrating inflammatory lesions. We found that this lymphocyte subset localization is not restricted to the skin, as we demonstrated that CD160 transcripts could be induced in IL-2 or IL-15-activated CD4+ peripheral blood lymphocytes. Finally, we report that CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Thus, we hypothesize that the unique CD4+ CD160+ lymphocyte subset plays a role in the pathogenesis of skin inflammation.","bibtype":"article","author":"Abecassis, S and Giustiniani, J and Meyer, N and Schiavon, V and Ortonne, N and Campillo, J A and Bagot, M and Bensussan, A","journal":"J Invest Dermatol","number":"5","bibtex":"@article{\n title = {Identification of a novel CD160+ CD4+ T-lymphocyte subset in the skin: a possible role for CD160 in skin inflammation},\n type = {article},\n year = {2007},\n identifiers = {[object Object]},\n keywords = {Adolescent,Adult,Aged,Amino Acid Sequence,Antigens, CD/genetics/*physiology,CD4-Positive T-Lymphocytes/immunology/*pathology,Cells, Cultured,Dermatitis, Atopic/etiology/*immunology,Dermatitis, Contact/etiology/*immunology,Female,Humans,Male,Middle Aged,Molecular Sequence Data,Psoriasis/etiology/*immunology,RNA, Messenger/genetics/physiology,Receptors, Immunologic/genetics/*physiology,Skin/immunology/*pathology/physiopathology,T-Lymphocyte Subsets/immunology/*pathology},\n pages = {1161-1166},\n volume = {127},\n websites = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17218942},\n edition = {2007/01/16},\n id = {26971d24-badd-3f4e-b6b4-3d5c1e3ece45},\n created = {2017-06-19T13:43:58.493Z},\n file_attached = {false},\n profile_id = {de68dde1-2ff3-3a4e-a214-ef424d0c7646},\n group_id = {b2078731-0913-33b9-8902-a53629a24e83},\n last_modified = {2017-06-19T13:43:58.696Z},\n read = {false},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n source_type = {Journal Article},\n language = {eng},\n notes = {<m:note>Abecassis, Sofia<m:linebreak/>Giustiniani, Jerome<m:linebreak/>Meyer, Nicolas<m:linebreak/>Schiavon, Valerie<m:linebreak/>Ortonne, Nicolas<m:linebreak/>Campillo, Jose A<m:linebreak/>Bagot, Martine<m:linebreak/>Bensussan, Armand<m:linebreak/>Research Support, Non-U.S. Gov't<m:linebreak/>United States<m:linebreak/>The Journal of investigative dermatology<m:linebreak/>5700680<m:linebreak/>J Invest Dermatol. 2007 May;127(5):1161-6. Epub 2007 Jan 11.</m:note>},\n abstract = {CD160 is a glycosylphosphatidylinositol-anchored cell surface molecule expressed by human circulating cytotoxic lymphocytes that correspond to the majority of natural killer cell (NK) expressing CD56(dim), TCRgammadelta lymphocytes, and to a minor CD8 T-cell subset. CD160 engagement by major histocompatibility complex class I molecules triggers by itself both cytotoxic function and cytokine production in NK lymphocytes, whereas it provides co-activating signals to TCR-induced proliferation in T CD8+ lymphocytes. In this study, we analyzed by immunohistochemistry the phenotype of lymphocytes infiltrating normal skin and inflammatory skin lesions of atopic dermatitis, contact dermatitis, and psoriasis. We identified a minor original subset of CD4+ CD160+ T cells infiltrating inflammatory lesions. We found that this lymphocyte subset localization is not restricted to the skin, as we demonstrated that CD160 transcripts could be induced in IL-2 or IL-15-activated CD4+ peripheral blood lymphocytes. Finally, we report that CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Thus, we hypothesize that the unique CD4+ CD160+ lymphocyte subset plays a role in the pathogenesis of skin inflammation.},\n bibtype = {article},\n author = {Abecassis, S and Giustiniani, J and Meyer, N and Schiavon, V and Ortonne, N and Campillo, J A and Bagot, M and Bensussan, A},\n journal = {J Invest Dermatol},\n number = {5}\n}","author_short":["Abecassis, S.","Giustiniani, J.","Meyer, N.","Schiavon, V.","Ortonne, N.","Campillo, J., A.","Bagot, M.","Bensussan, A."],"urls":{"Website":"http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17218942"},"bibbaseid":"abecassis-giustiniani-meyer-schiavon-ortonne-campillo-bagot-bensussan-identificationofanovelcd160cd4tlymphocytesubsetintheskinapossibleroleforcd160inskininflammation-2007","role":"author","keyword":["Adolescent","Adult","Aged","Amino Acid Sequence","Antigens","CD/genetics/*physiology","CD4-Positive T-Lymphocytes/immunology/*pathology","Cells","Cultured","Dermatitis","Atopic/etiology/*immunology","Dermatitis","Contact/etiology/*immunology","Female","Humans","Male","Middle Aged","Molecular Sequence Data","Psoriasis/etiology/*immunology","RNA","Messenger/genetics/physiology","Receptors","Immunologic/genetics/*physiology","Skin/immunology/*pathology/physiopathology","T-Lymphocyte Subsets/immunology/*pathology"],"downloads":0},"search_terms":["identification","novel","cd160","cd4","lymphocyte","subset","skin","possible","role","cd160","skin","inflammation","abecassis","giustiniani","meyer","schiavon","ortonne","campillo","bagot","bensussan"],"keywords":["adolescent","adult","aged","amino acid sequence","antigens","cd/genetics/*physiology","cd4-positive t-lymphocytes/immunology/*pathology","cells","cultured","dermatitis","atopic/etiology/*immunology","dermatitis","contact/etiology/*immunology","female","humans","male","middle aged","molecular sequence data","psoriasis/etiology/*immunology","rna","messenger/genetics/physiology","receptors","immunologic/genetics/*physiology","skin/immunology/*pathology/physiopathology","t-lymphocyte subsets/immunology/*pathology"],"authorIDs":[]}