@article{
 title = {Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial},
 type = {article},
 year = {2007},
 identifiers = {[object Object]},
 pages = {515-521},
 volume = {68},
 id = {312e4e24-0c04-3fda-b5b7-a0150ffe3d59},
 created = {2017-03-12T23:07:10.000Z},
 file_attached = {true},
 profile_id = {32112794-3515-31de-a0a8-eabadccd1b7c},
 group_id = {4cb6f261-be0d-3474-9ccf-7abee0d15aec},
 last_modified = {2017-04-12T22:04:21.073Z},
 read = {true},
 starred = {false},
 authored = {false},
 confirmed = {true},
 hidden = {false},
 notes = {NULL},
 folder_uuids = {30beeb5e-ec04-4936-88a8-a243a933478f},
 private_publication = {false},
 abstract = {OBJECTIVE: To determine the effect of smoked cannabis on the neuropathic pain of HIV-associated sensory neuropathy and an experimental pain model.\n\nMETHODS: Prospective randomized placebo-controlled trial conducted in the inpatient General Clinical Research Center between May 2003 and May 2005 involving adults with painful HIV-associated sensory neuropathy. Patients were randomly assigned to smoke either cannabis (3.56% tetrahydrocannabinol) or identical placebo cigarettes with the cannabinoids extracted three times daily for 5 days. Primary outcome measures included ratings of chronic pain and the percentage achieving >30% reduction in pain intensity. Acute analgesic and anti-hyperalgesic effects of smoked cannabis were assessed using a cutaneous heat stimulation procedure and the heat/capsaicin sensitization model.\n\nRESULTS: Fifty patients completed the entire trial. Smoked cannabis reduced daily pain by 34% (median reduction; IQR = -71, -16) vs 17% (IQR = -29, 8) with placebo (p = 0.03). Greater than 30% reduction in pain was reported by 52% in the cannabis group and by 24% in the placebo group (p = 0.04). The first cannabis cigarette reduced chronic pain by a median of 72% vs 15% with placebo (p < 0.001). Cannabis reduced experimentally induced hyperalgesia to both brush and von Frey hair stimuli (p < or = 0.05) but appeared to have little effect on the painfulness of noxious heat stimulation. No serious adverse events were reported.\n\nCONCLUSION: Smoked cannabis was well tolerated and effectively relieved chronic neuropathic pain from HIV-associated sensory neuropathy. The findings are comparable to oral drugs used for chronic neuropathic pain.},
 bibtype = {article},
 author = {Abrams, D. I. and Jay, C. a. and Shade, S. B. and Vizoso, H. and Reda, H. and Press, S. and Kelly, M. E. and Rowbotham, M. C. and Petersen, K. L.},
 journal = {Neurology},
 number = {7}
}

{"_id":"akmJwb38hv4kQZrTz","bibbaseid":"abrams-jay-shade-vizoso-reda-press-kelly-rowbotham-etal-cannabisinpainfulhivassociatedsensoryneuropathyarandomizedplacebocontrolledtrial-2007","downloads":0,"creationDate":"2017-12-17T23:25:46.705Z","title":"Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial","author_short":["Abrams, D., I.","Jay, C., a.","Shade, S., B.","Vizoso, H.","Reda, H.","Press, S.","Kelly, M., E.","Rowbotham, M., C.","Petersen, K., L."],"year":2007,"bibtype":"article","biburl":null,"bibdata":{"title":"Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial","type":"article","year":"2007","identifiers":"[object Object]","pages":"515-521","volume":"68","id":"312e4e24-0c04-3fda-b5b7-a0150ffe3d59","created":"2017-03-12T23:07:10.000Z","file_attached":"true","profile_id":"32112794-3515-31de-a0a8-eabadccd1b7c","group_id":"4cb6f261-be0d-3474-9ccf-7abee0d15aec","last_modified":"2017-04-12T22:04:21.073Z","read":"true","starred":false,"authored":false,"confirmed":"true","hidden":false,"notes":"NULL","folder_uuids":"30beeb5e-ec04-4936-88a8-a243a933478f","private_publication":false,"abstract":"OBJECTIVE: To determine the effect of smoked cannabis on the neuropathic pain of HIV-associated sensory neuropathy and an experimental pain model.\\n\\nMETHODS: Prospective randomized placebo-controlled trial conducted in the inpatient General Clinical Research Center between May 2003 and May 2005 involving adults with painful HIV-associated sensory neuropathy. Patients were randomly assigned to smoke either cannabis (3.56% tetrahydrocannabinol) or identical placebo cigarettes with the cannabinoids extracted three times daily for 5 days. Primary outcome measures included ratings of chronic pain and the percentage achieving >30% reduction in pain intensity. Acute analgesic and anti-hyperalgesic effects of smoked cannabis were assessed using a cutaneous heat stimulation procedure and the heat/capsaicin sensitization model.\\n\\nRESULTS: Fifty patients completed the entire trial. Smoked cannabis reduced daily pain by 34% (median reduction; IQR = -71, -16) vs 17% (IQR = -29, 8) with placebo (p = 0.03). Greater than 30% reduction in pain was reported by 52% in the cannabis group and by 24% in the placebo group (p = 0.04). The first cannabis cigarette reduced chronic pain by a median of 72% vs 15% with placebo (p < 0.001). Cannabis reduced experimentally induced hyperalgesia to both brush and von Frey hair stimuli (p < or = 0.05) but appeared to have little effect on the painfulness of noxious heat stimulation. No serious adverse events were reported.\\n\\nCONCLUSION: Smoked cannabis was well tolerated and effectively relieved chronic neuropathic pain from HIV-associated sensory neuropathy. The findings are comparable to oral drugs used for chronic neuropathic pain.","bibtype":"article","author":"Abrams, D. I. and Jay, C. a. and Shade, S. B. and Vizoso, H. and Reda, H. and Press, S. and Kelly, M. E. and Rowbotham, M. C. and Petersen, K. L.","journal":"Neurology","number":"7","bibtex":"@article{\n title = {Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial},\n type = {article},\n year = {2007},\n identifiers = {[object Object]},\n pages = {515-521},\n volume = {68},\n id = {312e4e24-0c04-3fda-b5b7-a0150ffe3d59},\n created = {2017-03-12T23:07:10.000Z},\n file_attached = {true},\n profile_id = {32112794-3515-31de-a0a8-eabadccd1b7c},\n group_id = {4cb6f261-be0d-3474-9ccf-7abee0d15aec},\n last_modified = {2017-04-12T22:04:21.073Z},\n read = {true},\n starred = {false},\n authored = {false},\n confirmed = {true},\n hidden = {false},\n notes = {NULL},\n folder_uuids = {30beeb5e-ec04-4936-88a8-a243a933478f},\n private_publication = {false},\n abstract = {OBJECTIVE: To determine the effect of smoked cannabis on the neuropathic pain of HIV-associated sensory neuropathy and an experimental pain model.\\n\\nMETHODS: Prospective randomized placebo-controlled trial conducted in the inpatient General Clinical Research Center between May 2003 and May 2005 involving adults with painful HIV-associated sensory neuropathy. Patients were randomly assigned to smoke either cannabis (3.56% tetrahydrocannabinol) or identical placebo cigarettes with the cannabinoids extracted three times daily for 5 days. Primary outcome measures included ratings of chronic pain and the percentage achieving >30% reduction in pain intensity. Acute analgesic and anti-hyperalgesic effects of smoked cannabis were assessed using a cutaneous heat stimulation procedure and the heat/capsaicin sensitization model.\\n\\nRESULTS: Fifty patients completed the entire trial. Smoked cannabis reduced daily pain by 34% (median reduction; IQR = -71, -16) vs 17% (IQR = -29, 8) with placebo (p = 0.03). Greater than 30% reduction in pain was reported by 52% in the cannabis group and by 24% in the placebo group (p = 0.04). The first cannabis cigarette reduced chronic pain by a median of 72% vs 15% with placebo (p < 0.001). Cannabis reduced experimentally induced hyperalgesia to both brush and von Frey hair stimuli (p < or = 0.05) but appeared to have little effect on the painfulness of noxious heat stimulation. No serious adverse events were reported.\\n\\nCONCLUSION: Smoked cannabis was well tolerated and effectively relieved chronic neuropathic pain from HIV-associated sensory neuropathy. The findings are comparable to oral drugs used for chronic neuropathic pain.},\n bibtype = {article},\n author = {Abrams, D. I. and Jay, C. a. and Shade, S. B. and Vizoso, H. and Reda, H. and Press, S. and Kelly, M. E. and Rowbotham, M. C. and Petersen, K. L.},\n journal = {Neurology},\n number = {7}\n}","author_short":["Abrams, D., I.","Jay, C., a.","Shade, S., B.","Vizoso, H.","Reda, H.","Press, S.","Kelly, M., E.","Rowbotham, M., C.","Petersen, K., L."],"urls":{"Paper":"http://bibbase.org/service/mendeley/6c9edcaf-81dc-3357-bb56-dee7616baa0c/file/03c1cb00-5474-d51b-4a8d-f928f77706d1/2007-Cannabis_in_painful_HIV-associated_sensory_neuropathy_A_randomized_placebo-controlled_trial.pdf.pdf"},"bibbaseid":"abrams-jay-shade-vizoso-reda-press-kelly-rowbotham-etal-cannabisinpainfulhivassociatedsensoryneuropathyarandomizedplacebocontrolledtrial-2007","role":"author","downloads":0},"search_terms":["cannabis","painful","hiv","associated","sensory","neuropathy","randomized","placebo","controlled","trial","abrams","jay","shade","vizoso","reda","press","kelly","rowbotham","petersen"],"keywords":[],"authorIDs":[]}