Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination. Adad, H., R., Donato, R., Pratavieira, S., O., Grecco, C., Brugnera-Jú, A., Bagnato, V., S., & Kurachi, C.
Clinical Comparison of Two Photosensitizers for Oral Cavity Decontamination [pdf]Paper  abstract   bibtex   
Objective: In this study, we aim to compare the photodynamic inactivation (PDI) effects of two different photosensitizers (PS), Photogem Ò and Natural Curcumin, irradiated with light-emitted diodes (LED) at 630 and 450 nm, respectively. Background: The current antimicrobial mouthwash for oral hygiene has several draw-backs. In this context, PDI is an alternative technique to inactivate pathogenic microbes in mucosa and in periodontal tissue. Furthermore, there are numerous infectious diseases that may affect the oral cavity, moti-vating the use of PDI in dentistry. Methods: The volunteers (n = 50) were randomize separated into five experimental groups (n = 5) for each PS: water control, PS control, light control, and two PS concentrations (25 and 100 mg/L). Each patient underwent mouthwash solution containing the PS before illumination procedure that was performed with an LED device. For microbial decontamination evaluation, the saliva was collected three times: before (T0), immediately after (T1), and 24 h after the illumination procedure (T2). After that, the difference between the colony forming units (CFU) for each volunteer was compared. Results: The results show that regardless of PS and treatment applied, there was microbial reduction immediately after PDI, however, after 24 h only Natural Curcumin still presents a reduction. For Photogem after 24 h, the microorganism returns to the original CFU. Conclusions: Immediately after PDI, both PS have the same efficiency, nevertheless the Natural Curcumin still has an efficacy after 24 h and also is a more viable photosensitizer. In addition, the results indicate that PDI can be a promised technique used for microbial reducing for the oral cavity.

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