@ARTICLE{Adorjan2019-rx,
  title    = "Neuroserpin expression during human brain development and in
              adult brain revealed by immunohistochemistry and single cell
              {RNA} sequencing",
  author   = "Adorjan, Istvan and Tyler, Teadora and Bhaduri, Aparna and
              Demharter, Samuel and Finszter, Cintia Klaudia and Bako, Maria
              and Sebok, Oliver Marcell and Nowakowski, Tomasz J and
              Khodosevich, Konstantin and M{\o}llg{\aa}rd, Kjeld and
              Kriegstein, Arnold R and Shi, Lei and Hoerder-Suabedissen, Anna
              and Ansorge, Olaf and Moln{\'a}r, Zolt{\'a}n",
  abstract = "Neuroserpin is a serine-protease inhibitor mainly expressed in
              the CNS and involved in the inhibition of the proteolytic
              cascade. Animal models confirmed its neuroprotective role in
              perinatal hypoxia-ischaemia and adult stroke. Although
              neuroserpin may be a potential therapeutic target in the
              treatment of the aforementioned conditions, there is still no
              information in the literature on its distribution during human
              brain development. The present study provides a detailed
              description of the changing spatiotemporal patterns of
              neuroserpin focusing on physiological human brain development.
              Five stages were distinguished within our examined age range
              which spanned from the 7th gestational week until adulthood. In
              particular, subplate and deep cortical plate neurons were
              identified as the main sources of neuroserpin production between
              the 25th gestational week and the first postnatal month. Our
              immunohistochemical findings were substantiated by single cell
              RNA sequencing data showing specific neuronal and glial cell
              types expressing neuroserpin. The characterization of neuroserpin
              expression during physiological human brain development is
              essential for forthcoming studies which will explore its
              involvement in pathological conditions, such as perinatal
              hypoxia-ischaemia and adult stroke in human.",
  journal  = "J Anat",
  volume   =  235,
  number   =  3,
  pages    = "543--554",
  month    =  jan,
  year     =  2019,
  keywords = "human brain; neurodevelopment; neuroserpin; subplate",
  language = "en"
}

{"_id":"fy3pLif3SMqtfteJZ","bibbaseid":"adorjan-tyler-bhaduri-demharter-finszter-bako-sebok-nowakowski-etal-neuroserpinexpressionduringhumanbraindevelopmentandinadultbrainrevealedbyimmunohistochemistryandsinglecellrnasequencing-2019","author_short":["Adorjan, I.","Tyler, T.","Bhaduri, A.","Demharter, S.","Finszter, C. K.","Bako, M.","Sebok, O. M.","Nowakowski, T. J","Khodosevich, K.","Møllgård, K.","Kriegstein, A. R","Shi, L.","Hoerder-Suabedissen, A.","Ansorge, O.","Molnár, Z."],"bibdata":{"bibtype":"article","type":"article","title":"Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing","author":[{"propositions":[],"lastnames":["Adorjan"],"firstnames":["Istvan"],"suffixes":[]},{"propositions":[],"lastnames":["Tyler"],"firstnames":["Teadora"],"suffixes":[]},{"propositions":[],"lastnames":["Bhaduri"],"firstnames":["Aparna"],"suffixes":[]},{"propositions":[],"lastnames":["Demharter"],"firstnames":["Samuel"],"suffixes":[]},{"propositions":[],"lastnames":["Finszter"],"firstnames":["Cintia","Klaudia"],"suffixes":[]},{"propositions":[],"lastnames":["Bako"],"firstnames":["Maria"],"suffixes":[]},{"propositions":[],"lastnames":["Sebok"],"firstnames":["Oliver","Marcell"],"suffixes":[]},{"propositions":[],"lastnames":["Nowakowski"],"firstnames":["Tomasz","J"],"suffixes":[]},{"propositions":[],"lastnames":["Khodosevich"],"firstnames":["Konstantin"],"suffixes":[]},{"propositions":[],"lastnames":["Møllgård"],"firstnames":["Kjeld"],"suffixes":[]},{"propositions":[],"lastnames":["Kriegstein"],"firstnames":["Arnold","R"],"suffixes":[]},{"propositions":[],"lastnames":["Shi"],"firstnames":["Lei"],"suffixes":[]},{"propositions":[],"lastnames":["Hoerder-Suabedissen"],"firstnames":["Anna"],"suffixes":[]},{"propositions":[],"lastnames":["Ansorge"],"firstnames":["Olaf"],"suffixes":[]},{"propositions":[],"lastnames":["Molnár"],"firstnames":["Zoltán"],"suffixes":[]}],"abstract":"Neuroserpin is a serine-protease inhibitor mainly expressed in the CNS and involved in the inhibition of the proteolytic cascade. Animal models confirmed its neuroprotective role in perinatal hypoxia-ischaemia and adult stroke. Although neuroserpin may be a potential therapeutic target in the treatment of the aforementioned conditions, there is still no information in the literature on its distribution during human brain development. The present study provides a detailed description of the changing spatiotemporal patterns of neuroserpin focusing on physiological human brain development. Five stages were distinguished within our examined age range which spanned from the 7th gestational week until adulthood. In particular, subplate and deep cortical plate neurons were identified as the main sources of neuroserpin production between the 25th gestational week and the first postnatal month. Our immunohistochemical findings were substantiated by single cell RNA sequencing data showing specific neuronal and glial cell types expressing neuroserpin. The characterization of neuroserpin expression during physiological human brain development is essential for forthcoming studies which will explore its involvement in pathological conditions, such as perinatal hypoxia-ischaemia and adult stroke in human.","journal":"J Anat","volume":"235","number":"3","pages":"543–554","month":"January","year":"2019","keywords":"human brain; neurodevelopment; neuroserpin; subplate","language":"en","bibtex":"@ARTICLE{Adorjan2019-rx,\n title = \"Neuroserpin expression during human brain development and in\n adult brain revealed by immunohistochemistry and single cell\n {RNA} sequencing\",\n author = \"Adorjan, Istvan and Tyler, Teadora and Bhaduri, Aparna and\n Demharter, Samuel and Finszter, Cintia Klaudia and Bako, Maria\n and Sebok, Oliver Marcell and Nowakowski, Tomasz J and\n Khodosevich, Konstantin and M{\\o}llg{\\aa}rd, Kjeld and\n Kriegstein, Arnold R and Shi, Lei and Hoerder-Suabedissen, Anna\n and Ansorge, Olaf and Moln{\\'a}r, Zolt{\\'a}n\",\n abstract = \"Neuroserpin is a serine-protease inhibitor mainly expressed in\n the CNS and involved in the inhibition of the proteolytic\n cascade. Animal models confirmed its neuroprotective role in\n perinatal hypoxia-ischaemia and adult stroke. Although\n neuroserpin may be a potential therapeutic target in the\n treatment of the aforementioned conditions, there is still no\n information in the literature on its distribution during human\n brain development. The present study provides a detailed\n description of the changing spatiotemporal patterns of\n neuroserpin focusing on physiological human brain development.\n Five stages were distinguished within our examined age range\n which spanned from the 7th gestational week until adulthood. In\n particular, subplate and deep cortical plate neurons were\n identified as the main sources of neuroserpin production between\n the 25th gestational week and the first postnatal month. Our\n immunohistochemical findings were substantiated by single cell\n RNA sequencing data showing specific neuronal and glial cell\n types expressing neuroserpin. The characterization of neuroserpin\n expression during physiological human brain development is\n essential for forthcoming studies which will explore its\n involvement in pathological conditions, such as perinatal\n hypoxia-ischaemia and adult stroke in human.\",\n journal = \"J Anat\",\n volume = 235,\n number = 3,\n pages = \"543--554\",\n month = jan,\n year = 2019,\n keywords = \"human brain; neurodevelopment; neuroserpin; subplate\",\n language = \"en\"\n}\n\n","author_short":["Adorjan, I.","Tyler, T.","Bhaduri, A.","Demharter, S.","Finszter, C. K.","Bako, M.","Sebok, O. M.","Nowakowski, T. J","Khodosevich, K.","Møllgård, K.","Kriegstein, A. R","Shi, L.","Hoerder-Suabedissen, A.","Ansorge, O.","Molnár, Z."],"key":"Adorjan2019-rx","id":"Adorjan2019-rx","bibbaseid":"adorjan-tyler-bhaduri-demharter-finszter-bako-sebok-nowakowski-etal-neuroserpinexpressionduringhumanbraindevelopmentandinadultbrainrevealedbyimmunohistochemistryandsinglecellrnasequencing-2019","role":"author","urls":{},"keyword":["human brain; neurodevelopment; neuroserpin; subplate"],"metadata":{"authorlinks":{}}},"bibtype":"article","biburl":"https://bibbase.org/f/EJMp3HRuxirjxpcXh/references.bib","dataSources":["sAFYeB74DpbdXM9NN","4zx9n2tbeLTix3Wxr","k3cdWrThyTh5o59Rm","hq9pebjzmsTuyxGGx","h8Atv2SAy4PmShg5j"],"keywords":["human brain; neurodevelopment; neuroserpin; subplate"],"search_terms":["neuroserpin","expression","during","human","brain","development","adult","brain","revealed","immunohistochemistry","single","cell","rna","sequencing","adorjan","tyler","bhaduri","demharter","finszter","bako","sebok","nowakowski","khodosevich","møllgård","kriegstein","shi","hoerder-suabedissen","ansorge","molnár"],"title":"Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing","year":2019}