@article{Agarwal2010,
	title = {Furan based cyclic homo-oligopeptides bind {G}-quadruplex selectively and repress c-{MYC} transcription},
	volume = {20},
	issn = {0960-894X},
	url = {http://www.sciencedirect.com/science/article/B6TF9-50B5PJ5-H/2/b9dd882ad9c7e28881a8b7793051f8d4 http://dx.doi.org/10.1016/j.bmcl.2010.06.080},
	doi = {10.1016/j.bmcl.2010.06.080},
	abstract = {We demonstrate the synthesis and selective binding of two novel furan based tricyclic homo-oligopeptides to G-quadruplex and using Real Time PCR show its repressive effect on c-MYC transcription. CD spectroscopy and FRET melting studies show that these ligands can induce G-quadruplex structures in the G rich 22 mer c-MYC DNA sequence and further stabilize the structure. Using real time polymerase chain reaction we observed that up to 70\% downregulation of c-MYC transcripts upon ligand treatment in HeLa cells.},
	number = {15},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	author = {Agarwal, Tani and Roy, Saumya and Kanti, Tushar and Maiti, Souvik and Chakraborty, Tushar Kanti},
	year = {2010},
	note = {tex.ids= agarwalFuranBasedCyclic2010
publisher: Elsevier Ltd},
	keywords = {Quadruplex Cancer c-MYC Macrocyclic compounds Olig},
	pages = {4346--4349 ST -- Furan based cyclic homo--oligopepti},
}

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