Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. Aghatabay, N. M, Neshat, a, Karabiyik, T, Somer, M, Haciu, D, & Dülger, B European journal of medicinal chemistry, 42(2):205–13, March, 2007.
Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. [link]Paper  doi  abstract   bibtex   
2,6-Bis(benzimidazol-2-yl)pyridine (L) ligand and complexes [M(L)Cl(2)] and [Fe(L)(2)](ClO(4))(2) (M=Zn, Cd, Hg) have been synthesized. The geometries of the [M(L)Cl(2)] complexes were derived from theoretical calculation in DGauss/DFT level (DZVP basis set) on CACHE. The central M(II) ion is penta-coordinated and surrounded by N(3)Cl(2) environment, adopting a distorted trigonal bipyramidal geometry. The ligand is tridentate, via three nitrogen atoms to metal centre and two chloride ions lie on each side of the distorted benzimidazole ring. In the [Fe(L)(2)](ClO(4))(2) complex, the central Fe(II) ion is surrounded by two (3N) units, adopting a octahedral geometry. The elemental analysis, molecular conductivity, FT-Raman, FT-IR (mid-, far-IR), (1)H, and (13)C NMR were reported. The antimicrobial activities of the free ligand, its hydrochloride salt, and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against 10 bacteria and the results compared with that for gentamycin. Antifungal activities were reported for Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, Hanseniaspora guilliermondii, and the results were referenced against nystatin, ketaconazole, and clotrimazole antifungal agents. In most cases, the compounds tested showed broad-spectrum (Gram positive and Gram negative bacteria) activities that were either more effective than or as potent as the references. The binding of two most biologically effective compounds of zinc and mercury to calf thymus DNA has also been investigated by absorption spectra.
@article{Aghatabay2007,
	title = {Synthesis, characterization and antimicrobial activity of {Fe}({II}), {Zn}({II}), {Cd}({II}) and {Hg}({II}) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand.},
	volume = {42},
	issn = {0223-5234},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/17189664},
	doi = {10.1016/j.ejmech.2006.09.023},
	abstract = {2,6-Bis(benzimidazol-2-yl)pyridine (L) ligand and complexes [M(L)Cl(2)] and [Fe(L)(2)](ClO(4))(2) (M=Zn, Cd, Hg) have been synthesized. The geometries of the [M(L)Cl(2)] complexes were derived from theoretical calculation in DGauss/DFT level (DZVP basis set) on CACHE. The central M(II) ion is penta-coordinated and surrounded by N(3)Cl(2) environment, adopting a distorted trigonal bipyramidal geometry. The ligand is tridentate, via three nitrogen atoms to metal centre and two chloride ions lie on each side of the distorted benzimidazole ring. In the [Fe(L)(2)](ClO(4))(2) complex, the central Fe(II) ion is surrounded by two (3N) units, adopting a octahedral geometry. The elemental analysis, molecular conductivity, FT-Raman, FT-IR (mid-, far-IR), (1)H, and (13)C NMR were reported. The antimicrobial activities of the free ligand, its hydrochloride salt, and the complexes were evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimal inhibitory concentration (MIC) dilution method, against 10 bacteria and the results compared with that for gentamycin. Antifungal activities were reported for Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, Hanseniaspora guilliermondii, and the results were referenced against nystatin, ketaconazole, and clotrimazole antifungal agents. In most cases, the compounds tested showed broad-spectrum (Gram positive and Gram negative bacteria) activities that were either more effective than or as potent as the references. The binding of two most biologically effective compounds of zinc and mercury to calf thymus DNA has also been investigated by absorption spectra.},
	number = {2},
	journal = {European journal of medicinal chemistry},
	author = {Aghatabay, Naz M and Neshat, a and Karabiyik, T and Somer, M and Haciu, D and Dülger, B},
	month = mar,
	year = {2007},
	pmid = {17189664},
	keywords = {\#nosource, Anti-Bacterial Agents, Anti-Bacterial Agents: chemical synthesis, Anti-Bacterial Agents: chemistry, Anti-Bacterial Agents: pharmacology, Antifungal Agents, Antifungal Agents: chemical synthesis, Antifungal Agents: chemistry, Antifungal Agents: pharmacology, Cadmium, Chelating Agents, Chelating Agents: chemical synthesis, Chelating Agents: chemistry, Disk Diffusion Antimicrobial Tests, Ferrous Compounds, Ferrous Compounds: chemical synthesis, Ferrous Compounds: chemistry, Ferrous Compounds: pharmacology, Fourier Transform Infrared, Heavy, Ligands, Magnetic Resonance Spectroscopy, Metals, Microbial Sensitivity Tests, Models, Molecular, Molecular Structure, Organomercury Compounds, Organomercury Compounds: chemical synthesis, Organomercury Compounds: chemistry, Organomercury Compounds: pharmacology, Organometallic Compounds, Organometallic Compounds: chemical synthesis, Organometallic Compounds: chemistry, Organometallic Compounds: pharmacology, Raman, Spectroscopy, Spectrum Analysis, Structure-Activity Relationship, Zinc},
	pages = {205--13},
}
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