The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide. Agmo, A. & Belzung, C. Neuropharmacology, 37(2):223--232, 1998. abstract bibtex Previous studies have shown that the opiate antagonist naloxone blocks the anxiolytic-like effects of benzodiazepines in several models of anxiety, including the elevated plus-maze. Although naloxone preferentially binds to the mu opioid receptor, its selectivity is rather low. The opioid receptor subtype important for anxiolytic-like actions of benzodiazepines in the plus-maze remains, therefore, unknown. In the present experiments, the ability of antagonists selective for subtypes of the opioid receptor to block the anxiolytic-like effects of chlordiazepoxide in the elevated plus-maze was evaluated in Swiss mice. Chlordiazepoxide, 5 mg/kg, increased the proportion as well as the number of open arms entries without modifying closed arms entries. Lower doses of the benzodiazepine were ineffective. The mu receptor antagonist beta-funaltrexamine, 10 and 20 mg/kg, the delta antagonist naltrindole, 10 mg/kg, and the kappa antagonist nor-binaltorphimine, 2.5 and 5 mg/kg, were then combined with chlordiazepoxide, 5 mg/kg. beta-funaltrexamine, 10 mg/kg, reduced the effects of the benzodiazepine while the dose of 20 mg/kg completely blocked the effects. Nor-binaltorphimine was ineffective at a dose of 2.5 mg/kg, but completely inhibited the actions of chlordiazepoxide when the dose was 5 mg/kg. Naltrindole was ineffective. None of the antagonists affected plus-maze behavior when administered alone. It was concluded that the mu and kappa receptors are important for the anxiolytic-like actions of chlordiazepoxide in the elevated plus maze.
@article{ agmo_role_1998,
title = {The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide},
volume = {37},
issn = {0028-3908},
abstract = {Previous studies have shown that the opiate antagonist naloxone blocks the anxiolytic-like effects of benzodiazepines in several models of anxiety, including the elevated plus-maze. Although naloxone preferentially binds to the mu opioid receptor, its selectivity is rather low. The opioid receptor subtype important for anxiolytic-like actions of benzodiazepines in the plus-maze remains, therefore, unknown. In the present experiments, the ability of antagonists selective for subtypes of the opioid receptor to block the anxiolytic-like effects of chlordiazepoxide in the elevated plus-maze was evaluated in Swiss mice. Chlordiazepoxide, 5 mg/kg, increased the proportion as well as the number of open arms entries without modifying closed arms entries. Lower doses of the benzodiazepine were ineffective. The mu receptor antagonist beta-funaltrexamine, 10 and 20 mg/kg, the delta antagonist naltrindole, 10 mg/kg, and the kappa antagonist nor-binaltorphimine, 2.5 and 5 mg/kg, were then combined with chlordiazepoxide, 5 mg/kg. beta-funaltrexamine, 10 mg/kg, reduced the effects of the benzodiazepine while the dose of 20 mg/kg completely blocked the effects. Nor-binaltorphimine was ineffective at a dose of 2.5 mg/kg, but completely inhibited the actions of chlordiazepoxide when the dose was 5 mg/kg. Naltrindole was ineffective. None of the antagonists affected plus-maze behavior when administered alone. It was concluded that the mu and kappa receptors are important for the anxiolytic-like actions of chlordiazepoxide in the elevated plus maze.},
language = {eng},
number = {2},
journal = {Neuropharmacology},
author = {Agmo, A. and Belzung, C.},
year = {1998},
pmid = {9680247},
keywords = {Animals, Anti-Anxiety Agents, Anxiety, Chlordiazepoxide, Male, Mice, Naltrexone, Narcotic Antagonists, Receptors, Opioid},
pages = {223--232}
}
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Lower doses of the benzodiazepine were ineffective. The mu receptor antagonist beta-funaltrexamine, 10 and 20 mg/kg, the delta antagonist naltrindole, 10 mg/kg, and the kappa antagonist nor-binaltorphimine, 2.5 and 5 mg/kg, were then combined with chlordiazepoxide, 5 mg/kg. beta-funaltrexamine, 10 mg/kg, reduced the effects of the benzodiazepine while the dose of 20 mg/kg completely blocked the effects. Nor-binaltorphimine was ineffective at a dose of 2.5 mg/kg, but completely inhibited the actions of chlordiazepoxide when the dose was 5 mg/kg. Naltrindole was ineffective. None of the antagonists affected plus-maze behavior when administered alone. It was concluded that the mu and kappa receptors are important for the anxiolytic-like actions of chlordiazepoxide in the elevated plus maze.","author":["Agmo, A.","Belzung, C."],"author_short":["Agmo, A.","Belzung, C."],"bibtex":"@article{ agmo_role_1998,\n title = {The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide},\n volume = {37},\n issn = {0028-3908},\n abstract = {Previous studies have shown that the opiate antagonist naloxone blocks the anxiolytic-like effects of benzodiazepines in several models of anxiety, including the elevated plus-maze. Although naloxone preferentially binds to the mu opioid receptor, its selectivity is rather low. The opioid receptor subtype important for anxiolytic-like actions of benzodiazepines in the plus-maze remains, therefore, unknown. In the present experiments, the ability of antagonists selective for subtypes of the opioid receptor to block the anxiolytic-like effects of chlordiazepoxide in the elevated plus-maze was evaluated in Swiss mice. Chlordiazepoxide, 5 mg/kg, increased the proportion as well as the number of open arms entries without modifying closed arms entries. Lower doses of the benzodiazepine were ineffective. The mu receptor antagonist beta-funaltrexamine, 10 and 20 mg/kg, the delta antagonist naltrindole, 10 mg/kg, and the kappa antagonist nor-binaltorphimine, 2.5 and 5 mg/kg, were then combined with chlordiazepoxide, 5 mg/kg. beta-funaltrexamine, 10 mg/kg, reduced the effects of the benzodiazepine while the dose of 20 mg/kg completely blocked the effects. Nor-binaltorphimine was ineffective at a dose of 2.5 mg/kg, but completely inhibited the actions of chlordiazepoxide when the dose was 5 mg/kg. Naltrindole was ineffective. None of the antagonists affected plus-maze behavior when administered alone. It was concluded that the mu and kappa receptors are important for the anxiolytic-like actions of chlordiazepoxide in the elevated plus maze.},\n language = {eng},\n number = {2},\n journal = {Neuropharmacology},\n author = {Agmo, A. and Belzung, C.},\n year = {1998},\n pmid = {9680247},\n keywords = {Animals, Anti-Anxiety Agents, Anxiety, Chlordiazepoxide, Male, Mice, Naltrexone, Narcotic Antagonists, Receptors, Opioid},\n pages = {223--232}\n}","bibtype":"article","id":"agmo_role_1998","issn":"0028-3908","journal":"Neuropharmacology","key":"agmo_role_1998","keywords":"Animals, Anti-Anxiety Agents, Anxiety, Chlordiazepoxide, Male, Mice, Naltrexone, Narcotic Antagonists, Receptors, Opioid","language":"eng","number":"2","pages":"223--232","pmid":"9680247","title":"The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide","type":"article","volume":"37","year":"1998","bibbaseid":"agmo-belzung-theroleofsubtypesoftheopioidreceptorintheanxiolyticactionofchlordiazepoxide-1998","role":"author","urls":{},"keyword":["Animals","Anti-Anxiety Agents","Anxiety","Chlordiazepoxide","Male","Mice","Naltrexone","Narcotic Antagonists","Receptors","Opioid"],"downloads":0},"bibtype":"article","biburl":"https://api.zotero.org/users/1159944/collections/PSAWXGQV/items?key=8pKJLEr2Uh7GZN5GrRPdT9lZ&format=bibtex&limit=100","creationDate":"2015-02-11T08:35:10.011Z","downloads":0,"keywords":["animals","anti-anxiety agents","anxiety","chlordiazepoxide","male","mice","naltrexone","narcotic antagonists","receptors","opioid"],"search_terms":["role","subtypes","opioid","receptor","anxiolytic","action","chlordiazepoxide","agmo","belzung"],"title":"The role of subtypes of the opioid receptor in the anxiolytic action of chlordiazepoxide","year":1998,"dataSources":["FRxCKR7bxZrk5oFSo"]}