Von Hippel-Lindau Disease: The Importance of Retinal Hemangioblastomas in Diagnosis. Şahin Atik, S., Solmaz, A. E., Öztaş, Z., Eğrilmez, E. D., Uğurlu, Ş., Atik, T., & Afrashi, F. Turkish Journal of Ophthalmology, 47(3):180–183, June, 2017. doi abstract bibtex Von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by benign or malignant tumors which may involve more than one system. Retinal hemangioblastomas are usually the initial manifestation of VHL disease and can cause vision loss. A 32-year-old man presented to our clinic with vision loss in the left eye for 2 months. He had a history of cerebral hemangioblastoma operation. Family history showed that his mother had unilateral vision loss and died because of renal cell carcinoma. Ophthalmologic examination revealed multiple retinal hemangioblastomas in both eyes. VHL gene sequencing was performed and heterozygous p.R161X mutation was detected. His sister and daughter were also found to have the same variant. A treatment and follow-up plan was initiated for the patient and affected family members. Considering VHL disease in the differential diagnosis of retinal hemangioblastomas has a very important role in the early detection of life-threatening tumors in these patients.
@article{sahin_atik_von_2017,
title = {Von {Hippel}-{Lindau} {Disease}: {The} {Importance} of {Retinal} {Hemangioblastomas} in {Diagnosis}},
volume = {47},
issn = {2149-8695},
shorttitle = {Von {Hippel}-{Lindau} {Disease}},
doi = {10.4274/tjo.90912},
abstract = {Von Hippel-Lindau (VHL) disease is a familial cancer syndrome characterized by benign or malignant tumors which may involve more than one system. Retinal hemangioblastomas are usually the initial manifestation of VHL disease and can cause vision loss. A 32-year-old man presented to our clinic with vision loss in the left eye for 2 months. He had a history of cerebral hemangioblastoma operation. Family history showed that his mother had unilateral vision loss and died because of renal cell carcinoma. Ophthalmologic examination revealed multiple retinal hemangioblastomas in both eyes. VHL gene sequencing was performed and heterozygous p.R161X mutation was detected. His sister and daughter were also found to have the same variant. A treatment and follow-up plan was initiated for the patient and affected family members. Considering VHL disease in the differential diagnosis of retinal hemangioblastomas has a very important role in the early detection of life-threatening tumors in these patients.},
language = {eng},
number = {3},
journal = {Turkish Journal of Ophthalmology},
author = {Şahin Atik, Sevinç and Solmaz, Aslı Ece and Öztaş, Zafer and Eğrilmez, Emine Deniz and Uğurlu, Şeyda and Atik, Tahir and Afrashi, Filiz},
month = jun,
year = {2017},
pmid = {28630796},
pmcid = {PMC5468534},
keywords = {Renal cell carcinoma, Von Hippel-Lindau syndrome, retinal hemangioblastoma},
pages = {180--183},
}
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Family history showed that his mother had unilateral vision loss and died because of renal cell carcinoma. Ophthalmologic examination revealed multiple retinal hemangioblastomas in both eyes. VHL gene sequencing was performed and heterozygous p.R161X mutation was detected. His sister and daughter were also found to have the same variant. A treatment and follow-up plan was initiated for the patient and affected family members. 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